rabbit journal summaries

8/14/2019 Rabbit Journal Summaries

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Rabbit

Retrospective Study of Neurological Disease in 118 Rabbits: 78 animals (66.1%) hadinflammatory lesions of the CNS. Encephalitozoonosis was diagnosed in 69 (58.5%) of

these rabbits and 2 animals had herpes simplex virus encephalitis.

Cystic Mammary Adenocarcinoma Associated with a Prolactin-secreting Pituitary Adenoma in a New Zealand White Rabbit (Oryctolagus cuniculus ). Vol 58, No 3 June 2008. Histologicevaluation confi rmed the presence of a pituitary adenoma, mammaryhyperplasia, dysplasia, and cystic mammary adenocarcinoma.Immunohistochemical staining confi rmed the presence of abundantprolactin secreting cells in the pituitary adenoma.

Solitary Biliary Hamartoma with Cholelithiasis in a Domestic Rabbit

(Oryctolagus cuniculus). Vet Pathol 44:9295 (2007). network of large varying sized

cystic structures lined by simple cuboidal to columnar epithelium within an abundantfibrous stroma. Within many of the cyst lumina were varying sized, pale white to

greenish hard concretions identified as choleliths and were analyzed and found to be

composed of calcium carbonate. (human synonym=von MeyenburgComplexes).

Effects of Autologous Stem Cells on Immunohistochemical Patterns and Gene

Expression of Metalloproteinases and Their Tissue Inhibitors in Doxorubicin

Cardiomyopathy in a Rabbit Model. Vet Pathol 44:494503 (2007). In conclusion,

chronic doxorubicin cardiomyopathy was characterized by increased MMP and decreased

TIMP-3 expression. MSCs injection into the LV resulted in marked differences of

collagen content and MMP/TIMP expression in the whole heart. After MSC injection,MMP-1, MMP-2, and TIMP-3 expression was higher.

Testicular Interstitial Cell Tumor and Gynecomastia in a Rabbit. Vet Pathol

44:513517 (2007). Neoplastic interstitial cells exhibited diffuse, granular cytoplasmic

staining with Melan A. Multiple subcutaneous masses in the caudal abdomen were

associated with enlarged nipples and consisted of hyperplastic mammary gland tissuewith proliferation of ducts and alveoli, marked lobule formation, and pseudolactational

hyperplasia. Many epithelial cells lining the hyperplastic ducts and alveoli exhibited

intense nuclear expression of progesterone receptor antigen, whereas myoepithelial cellsshowed strong nuclear staining for p63 antigen.

Cutaneous Neoplasms in Pet Rabbits: A Retrospective Study. Vet Pathol 44:579588(2007). The most common diagnoses were trichoblastoma, collagenous hamartoma, and

Shope fibroma. Viral-induced tumors were Shope fibroma (19) and Shope papilloma (2).

Common nonviral epithelial tumors included trichoblastoma (59), squamous cellcarcinoma (5), squamous papilloma (4), trichoepithelioma (3), and apocrine carcinoma

(3). Common mesenchymal tumors were lipoma (10), liposarcoma (3), myxosarcoma (9),

malignant peripheral nerve sheath tumor (8), fibrosarcoma (7), and leiomyosarcoma (4).


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Spontaneous Osteosarcoma in a Rabbit (Oryctolagus cuniculus). Vet Pathol 44:691

694 (2007). Proliferative and destructive lesions of bone were observed. On histologicexamination, the tumor was composed of proliferating neoplastic cells that resembled

histiocytes, with abundant osteoid production. A large number of multinucleated giant

cells were found throughout.

Spontaneously Occurring Alimentary Osteofluorosis Associated with Proliferative

Gastroduodenopathy in Rabbits. Vet Pathol 44:703706 (2007). Painful thickeningsof the extremities, multiple osseous proliferations of extremities and mandibles and a

mild to severe proliferative gastroduodenopathy. Histologically, periosteal and

endosteal hyperostosis and a mild to severe proliferation of the gastric and duodenal

mucosa were noted. Major clinical manifestations of chronic fluoride intoxication aredental fluorosis and osteofluorosis. Dental fluorosis is characterized by enamel mottling

and hypoplasia, and osteofluorosis by periosteal hyperostosis displaying a roughened

irregular surface.

Granular Cell Tumor in the Testis of a Rabbit: Cytologic, Histologic, Immunohistochemical, and

Electron Microscopic Characterization Vet Path 2008 Jan: GCT may occur in the genital tract,

including the vulva, clitoris, vagina, cervix, and/oruterus of cats, rodents. The tumor cells were vimentin,

Melan A, NSE and Ki67 positive. DDx is leydig cell tumor

Choriocarcinoma with Metastasis in a Rabbit Vet Path 2008 Jan: uterine mass consistedof 3 different

(trophoblastic, syncytiotrophoblastic, and cytotrophoblastic); positive cytokeratin in all 3 cell types,and thesyncytiotrophoblasts were positive also for human chorionicgonadotropin. Choriocarcinoma is a highly

malignant neoplasm of trophoblasticcells arising in placental tissue, ovary, testis, or sequesteredremains of

totipotential cells in the mediastinum or abdomen

The Immunohistochemical Evaluation of Estrogen Receptor-{alpha} and Progesterone Receptors of

Normal, Hyperplastic, and Neoplastic Endometrium in 88 Pet Rabbits Vet Path 2008 Mar:59.3%

normal and 68.4% of hyperplastic uteri stained positivewith both ER- and PR. Papillaryadenocarcinoma

infiltrated the myometrium late in the disease, with thinning of myometrium and 80.8% were bothER-

and PR negative. Tubular/solidadenocarcinoma invaded into the deep myometrium early in thedisease and

93.8% were positive for ER- , PR, or both, suggesting that there may be 2 different developmental

pathwaysfor uterine adenocarcinomas in the rabbit.

An Outbreak of Fatal Herpesvirus Infection in Domestic Rabbits in Alaska Vet Path 2008 May:

Clinical signs included conjunctivitis and periocular swelling, ulcerative dermatitis, progressive

weakness, anorexia, respiratory distress, and abortion. Hemorrhagic dermatitis and panniculitis were

associated with epidermal microvesicular degeneration, dermal and subcutaneous vascular necrosis,and thrombosis. Eosinophilic intranuclear inclusions consistent with herpesvirus were found within the

epidermis and superficial follicular epithelium and within mesenchymal cells within the dermis andsubcutis. Syncytial cells containing viral inclusions occurred within the epidermal and superficial follicular

epithelium. Other findings were hemorrhagic necrosis of the myocardium with rare intranuclear

inclusions within stromal cells, multifocal pulmonary hemorrhage, hemorrhage with sinus

erythrophagocytosis in lymph nodes, and massive necrosis and fibrin deposition within red pulp of

the spleen.


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Spinal lymphoma and pulmonary filariasis in a pet domestic rabbit (Oryctolagus

cuniculus domesticus). J Vet Diagn Invest 21:253256 (2009). Spinal lymphoma and

concurrent pulmonary filariasis are reported in a pet rabbit. The rabbit presented forpelvic limb paralysis resulting from extradural spinal lymphoma, presumably rising from

the body of the sixth lumbar vertebra. The neoplasm was subsequently

immunophenotyped as a B-cell lymphoma. Pulmonary filariasis was an incidental findingat necropsy.

Spontaneous Deciduosarcoma in a Domestic Rabbit (Oryctolagus cuniculus). Vet

Pathol 43:377-380 (2006 may)

Deciduosarcoma

- Hormonally dependent malignancy

- Reported only in rabbits in toxicology studies involving estrogens with or withoutprogestins

- Induced in female rabbits and in the spleens of castrated male rabbits given estrogen

CASE described:

- spindloid cells and large epithelioid cells- Giant cells with large, bizarre, hyperchromatic nuclei were common

- Positive for vimentin and progesterone and estrogen receptors- Negative for pancytokeratin (AE1/AE3), cytokeratin 18, desmin, alpha-smooth muscle

actin (SMA), and CD10 (marker for nondecidualized endometrial stroma)

Intraocular sarcomas in two rabbits J Vet Diagn Invest 21:547551 (2009).

pleomorphic, poorly differentiated, invasive, intraocular spindle cell neoplasm closely

associated with lens and lens capsular fragments. strong, diffuse expression for vimentin;

however, staining for smooth muscle actin, cytokeratin, S100, and desmin werenegative. The histologic features of these intraocular neoplasms closely resemble post-

traumatic ocular sarcomas in cats.

Capillaria hepatica infection in Lab Rabbits: Tox Path 37 2009: Dilated bile ducts

with luminal debris and fibrosis. Macrogranulomas in portal areas with eggs,

macrophages, and eosinophils, and lymphocytes. Microgranulomas with epithelioidmacrophages with eosinophils and lymphocytes. C hepatic eggs in lumen of bile ducts

and gall bladder. Adults were not seen, but liver in liver.

Granulomatous Pneumonia Caused by Mycobacterium genavense in a Dwarf

Rabbit (Oryctolagus cuniculus). Vet Pathol 46:10001002 (2009). The main

macroscopic findings were a watery red pleural effusion and some whitish striated foci in

the lungs. severe granulomatous pneumonia with detection of acid-fast bacilli, in thekidneys, an interstitial chronic lymphoplasmacellular nephritis with interstitial fibrosis,

and in the brain, a multifocal granulomatous and partly necrotizing encephalitis with

detection of spores, suggestive of encephalitozoonosis

Reversible Fibroadenomatous Mammary Hyperplasia in Male and Female New

Zealand White Rabbits Associated with Cyclosporine A Administration. Vet Pathol

46:11441148 (2009). glandular hyperplasia with mild cellular atypia and ductal ectasia


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separated by abundant hypercellular fibrous stroma, consistent with fibroadenomatous

mammary gland hyperplasia. The hyperplasia resolved within 2 weeks of cessation of

cyclosporine, and at necropsy identifiable mammary masses were not found.

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