r graphics output - harvard universitypklab.med.harvard.edu/ruslan/neural_crest/data s2.pdfmark1...

21
cluster 1 ●● ●● ●● ●● ●● ●● ●● ●● Dbp Nkx1-2 Neurog2 Nrarp Hes6 Pou4f1 Car11 Lhpp Nedd9 Tubb3 Lrig1 5031439G07Rik Prdm12 Igdcc3 Spsb4 Utrn Gfra1 Cxx1c Fam89a Mgll Apod Trim62 Smtnl2 Oat Nmnat2 2700046A07Rik Rpl7 Fam81a Grrp1 Slitrk2 Ctsk Fgd4 Papss1 Srgap3 2510009E07Rik 5730559C18Rik Baiap2l1 Cxcr7

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Page 1: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Dbp

Nkx1−2

Neurog2

Nrarp

Hes6

Pou4f1

Car11

Lhpp

Nedd9

Tubb3

Lrig1

5031439G07Rik

Prdm12

Igdcc3

Spsb4

Utrn

Gfra1

Cxx1c

Fam89a

Mgll

Apod

Trim62

Smtnl2

Oat

Nmnat2

2700046A07Rik

Rpl7

Fam81a

Grrp1

Slitrk2

Ctsk

Fgd4

Papss1

Srgap3

2510009E07Rik

5730559C18Rik

Baiap2l1

Cxcr7

Page 2: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Hoxa7

Hoxb9

Msx3

Nr6a1

Lef1

Hoxc6

Tcf7

Dazap2

Sox9

2700086A05Rik

Hn1l

Mira

Tom1l1

Serinc5

Fgfr4

Steap1

Shb

Abcc8

Tmem59l

Tnfrsf19

Anpep

Cxcr4

Cldn1

Fgfbp3

Ppp1r1a

Aldh1a2

Greb1l

Sgpp2

Ppp2r2b

Rdh10

Spata13

Prex1

Gpsm2

Ptn

Lect1

Krtcap2

Pmp22

Ugdh

4930452G13Rik

Page 3: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Prrx1

Prrx2Fli1

Six2

Twist1

Prdm1Snai2

Foxc1Ebf3

Etv4

Dlx1Barx1

Foxp2Ebf2

Meox1

Dlx6

Dnm3osCol3a1PcolceTns1Cxcl12

Cped1Cd248

Rab3il1Gng8Sema3fPpfibp2Epha3PdgfrbMecom

Olfml1

Vcam1BgnHopx

Dpep1Fbln1Fzd4ClmpEfemp1Scara3Dlx1asFlrt2Ddr2

Tmem204DutSpry1Wnt5aStambpl1Fbln5Dusp9PlvapDnm1Il17rdCrispld1

Aff2Mab21l1Sh2d3c

TgfbiTnfaip6Eva1bCol26a1Nid1Col23a1

H2afy2

Hkdc1

Sh3bp5Dlx6as1Dact3DesMfap4Fhl3Sparcl1Ptx3Lpar1Wdr86Bzw2Id1

2610018G03RikFrmd7Arg1Fndc5

Page 4: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Sox4

Psmd10

Bach2

Enpp2

Nme1

Nme4

Slc25a5

Nme2

Sdc3

Atpaf2

Litaf

Cct8

Kctd15

Kif21b

Fzd7

Cdk18

Fam212a

Eif5a

Crlf3

Meis3

Pabpc1

Sept9

Pcdh18

Tfap2a

C330018D20Rik

Gsto1

Csk

Tfap2b

Pfn1

Bcat1

Itm2a

Josd2

Emilin1

Phlda1

Phb

Vcan

Fgd1

Ccdc85b

Mycn

S1pr2

Rplp0

Prdx6

Dlc1

Mtch2

Ppic

Gap43

Pcbp4

Ppp1r14b

Psat1

Nrp1

Sulf2

Camk2b

Chpf

Csn3

Phc2

Page 5: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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BC024139

Rfx4

Zic1

Zic3

Rfx2Notch4

Foxb1Sox1

Pou3f2

Zic2

Rem2

Bmp6Wnt9aCrb3Gdf7DtnaNrg3Plekha6Ddit4lTm4sf4Tspan33Zcchc18Fam167aGm7694Casz1Cp

Rspo1

Gpr98Tmem255aFgfbp1Galnt12

Nos1apPtplad2Ankrd13d

RmstKrt18AI836003Trabd2bEmp1KynuFcgrtCntnap2Fam131aZic4Fam117aSyt6Cables1Slc25a23Kif1a

Wnt4Cacna1gHspa4lIkzf2Olig3

Arhgap24Myl1Folr1Plch1Fam13cLect2Arhgef28Bnc2PlecNhsl1Ntrk2Ly6h

2610017I09Rik2700069I18RikSrpxGpr56Thbs1Plxnc1Rspo3Vil1

Cadm2Wnt3Ube2ql1RprmEfhc2Rbm47Hs6st1Porcn

CpmThsd4Aldh3b2Gm10664Nsg2NppcWnt3aMyh7bNdpIsm1Hook1

MaobGm2694

2610100L16RikFn3k

Page 6: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Tob1

Fhl2

Maged1

Mafb

Asb4

Dach2

Crip2

Ccdc23

Adamts15

Srgap1

Wwtr1

Shank1

Ccdc42

Cd59a

Gnb2

Ahnak

Ddr1

Kcnj12

Ptpn14

Armcx1

Gpx3

Wls

Klhdc8b

Efnb3

Ptprd

Grifin

Ccdc88c

Nell2

Sema6d

Parp8

Id2

Ptpn13

Sparc

2810055G20Rik

Pea15a

Zfand5

Cd9

Jam2

Scd2

Igfbp5

Gabarap

Id3

Tuba1a

Page 7: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Tbx3

Pdlim4

Foxd2

Basp1

2500004C02Rik

Crabp1

Ralgds

Tbca

Cox7b

9130206I24Rik

Fth1

Nnat

Map2k6

Pnrc1

Atp5c1

Slc25a4

Ifitm2

Etfa

Eif4e3

Tmem132e

Arhgap42

Csrp1

Mfap2

Stmn1

Tsc22d3

Shc2

Mrpl34

Ppib

Synpo

Hip1

Auts2

Myo1b

Gng10

Igfbp3

Atoh8

Rbbp9

Unc5c

Page 8: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Heyl

Insm1

Isl1

Notch1

Hoxc4

Hoxc5

Fxyd3

Chst1

Cadm1

Crispld2

Tgfbr3

Man1c1

Slc45a3

Fam210b

Lgi4

Coro1c

Zbtb18

Elavl4

Tmsb4x

Nedd4

Fhdc1

Tspan18

Marcksl1

Trp53i11

Nkain4

Galnt18

Gnas

Cyfip2

Afap1

Gdpd5

1810011O10Rik

Fam101a

8430427H17Rik

1700019D03Rik

Sbk1

1810043G02Rik

Sfrp5

Fbxo44

Gamt

Cthrc1

Itga9

Pag1

Ppp1r14a

St5

Slc25a26

Rbms3

Plcd1

Gse1

Sepp1

H19

Metrn

Chrnb4

Fabp5

Ccnd2

Fscn1

Plcg2

Chrna4

Rgs16

Pdgfc

Crabp2

Atp6v0e2

Fabp7

Page 9: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Mybbp1a

Tcf12

Ruvbl2

Myc

Srm

Exosc6

Nhp2

Ppid

Rsl1d1

Mrpl12

Cct6a

Ctps

Gnl3

Gemin5

Cct5

Pa2g4

Nolc1

Tcof1

C1qbp

Ncl

Cct3

Chchd4

Tomm70a

Nop2

Npm1

Gm11974

Eif3b

Tomm5

Mak16

Nop56

Ppan

Nip7

Ddx21

Eif2b3

Ddx39

Phb2

Bop1

Ran

Wdr77

Mrto4

Ppa1

Rcl1

Cacybp

Cnbp

Dctd

Serbp1

Hspa9

Fkbp1a

Hspd1

Nsun2

Sdc1

Shmt1

Dusp4

Smyd2

Hk2

Page 10: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Maf

Hoxc9

Hoxd8

Hoxb1

Pawr

Hoxc8

Sall3

Hes1

Hoxa9

Msx2

Gja1Sp8Ifitm1Slc25a48Hapln1Dync1i1Egln3Leprel1Rbpms2Cystm1TchhFstH2−D1

Slc2a3

Mark1Slc2a1Gprc5aSema3aChrdl1

ZyxCol14a1

NaaaAprt

CenpvBmper

BocScrn1

Ptprz1Prr5l

F11r

Ssr1Sytl2MestPhyhiplFkbp11Pmaip1Zfp593St3gal6Plp2DdnTagln2Col2a1Tpi1H2−K1Ipo5Serp1Slc16a3Cdh11Pla2g7NogMllt4DmdPak3Serinc2EpycChst15

Ccnd1Itga8Mogat2LdhaEif4a1AldoaEif2s1Nop58Ebna1bp2Mat2aGprc5cMcc

Page 11: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Hoxa5

Hoxb5

Sox2

Hoxb8

Pax3

Hoxb6

Hoxb7

Foxd3

Notch2

Dtx4

Tubb2b

Gfra3

Slc9a3r1

Uchl1

Nrp2

Tshz1

Lfng

Vim

Tspan13

Col18a1

Cdh6

Fam181b

Ptms

Ednrb

Phldb1

Ubl3

Bcar3

Page 12: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Msx1

Ldb2

Dach1

Gyltl1b

Lin7a

E130309F12Rik

Msx1as

Mdk

Ak7

Grem1

Zfp185

Thbs3

Gdf6

Glis3

Cdon

Pltp

Hnf1b

Adamts3

Zic5

Bcam

Clec2l

Cx3cl1

Cxadr

Rftn1

Dclk2

Ptprk

Fgfr3

Metrnl

Ptchd4

2610035F20Rik

Adamts19

Dact2

Cep170b

Lrp2

Apoe

Klhl29

Ctgf

Fn1

Efnb1

Bmp4

Slc16a10

Zfhx4

Kank1

Pdia6

Rnd1

Shroom3

Palm3

Skap1

Colec12

Tpbg

Cpe

Gdf10

Slit2

Agtrap

Ank3

Ablim1

Tox3

Igfbpl1

Bet3l

Page 13: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Sp5

Cdx1

Dek

Gbx2

Axin2

A730017C20Rik

Slit1

Fgfr2

Dpysl5

Tmem132c

Arl4c

Map1b

Ezr

Apba2

Nkd1

Cdh2

Wfikkn1

Cpn1

Car4

Grb7

Lama5

Bex1

Wscd1

Gsr

Igfbp2

Cd24a

Pcsk9

Gldc

Prom1

Mapk12

Msrb3

Unc13b

Mycl1

Sema3c

Car14

Gpc3

Draxin

Zfp703

Ror2

Ncald

Gas1

Col4a2

Col4a1

Has2

Page 14: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Smarca2

Dlx2

Prkar1a

Elk3

Nfic

Ssbp4

Foxe3

Rarg

Nr2f1

Pbx1

Col5a1Rbp1Ppap2bAlx1Arap3Pkn1Timp3Mt1FlnaEfemp2

TecrlTmem98

Ccl6

Ndst3Dlk1S100a16Pxdc1Tril

Hsd11b2Lhfpl2

Limd2Lgr4Vamp8SpegLima1Limch1Slitrk6Cnn2

Tenc1Zcchc24Tmem119PtpruTmsb10RhojSema3d

Lrrfip1Mamdc2Igfbp4Spry2MdfiMmp2

A830082K12Rik

Kitl

Page 15: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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cluster 15

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Mef2c

Pdlim1

Tcf7l2

Jup

Tmem55a

Mcam

Dnajc1

Zswim7

Anxa5

Postn

Fam129b

Spon1

Sh3pxd2a

Myl9

Lyn

Ralb

Cdh19

Anxa6

L1cam

Gstk1

Gstp1

Megf6

Actb

Fbln2

Mbnl2

Plxna4

Lxn

Arhgef40

Sipa1

Serpinf1

Hs3st3b1

Ednra

Angptl1

Cald1

Serpine2

BC064078

Shroom2

Gng11

Nlgn3

Ppfibp1

Crmp1

Mme

Slit3

Page 16: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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cluster 16

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Lmx1a

Rab11a

Plagl1

Rab8b

Reep2

C920025E04Rik

Col4a5

Crb2

Slc35g1

Sema5b

Plce1

Coch

Jakmip2

Unc5a

Gm5089

1700011H14Rik

Ildr2

Col4a6

Pcsk1

Celsr1

Clybl

Dhx32

Fsd1l

Prdm6

Cercam

Fzd10

Gnai2

Fndc3b

H2−Ke6

Nrxn2

Fhl1

Llgl2

Cenpw

Pak1

Ston2

Arf1

Podxl

Arl4a

Golm1

Wnt1

Fgf15

Nuak2

C130026L21Rik

F3

Irs1

Calm1

Gadd45a

Dusp5

Pcdh7

Page 17: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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cluster 17

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Gas7

Lbh

Sox8

Lmo4

Jun

Hoxd3

Pkig

Ret

Itga4

Nudt7

Vat1l

Ngfr

Smox

Cdhr2

Ctnnb1

Vash1

Suox

Fam198b

Cfl1

Cpne5

2810468N07Rik

Mpz

Insc

Phactr1

Col1a2

Adam12

Marcks

Lama4

Pcdh1

Klhl13

Dagla

Rai2

Gfra2

Megf10

Flrt1

Nrep

Map3k11

Dbi

Cuedc2

Rgcc

Gpc1

Coro2b

Prps2

Akr1a1

Ywhab

Cotl1

Palm

Fxyd1

Sntb1

Zeb2

Slc1a3

Pls3

Grb10

Rhob

Ftl1

Celsr2

Page 18: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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cluster 18

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Neurod1

Neurod4

Nhlh1

Neurog1

Nhlh2

Onecut1

Tlx2

Six4

Six1

Hes5

Gpr20

Fam83f

2410137F16Rik

Tbc1d9

Upp1

Spock2

Gadd45g

Srrm4

Wscd2

Rapgef5

Eya2

Mfng

Sstr2

Frrs1l

Ppp1r17

Elavl3

Sncb

Brsk2

Gm16551

Olfm2

Rhbdl3

Adamtsl2

Dll1

Nfasc

Trim9

Plk2

Artn

Tagln3

Myo5b

Spint2

Btbd17

Pcdh8

Chrna3

Dll3

Timm50

Ly6e

Tpm4

Pik3c2b

Page 19: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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cluster 19

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Lmo1

Phox2b

Ascl1

Tbx2

Dnmt3a

Hmgcs1

Cst3

Ypel5

Pdlim7

Cnn3

Nxph4

Peg10

Cox4i1

Ddit4

Ckb

Ddah2

Rhoc

Tmem2

Cdkn1c

2010001M06Rik

Myadm

Sfrp1

Lcp2

Efnb2

Cacna1h

Tln1

Myh10

Myl12a

Lasp1

Plxna2

Page 20: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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cluster 20

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Junb

Peg3

Snai1

Dlx5

Elovl6

Itgb5

Pdgfra

Oaf

Cyr61

Prickle1

Gng12

Vasn

Fstl1

Ccnd3

Akap12

Farp1

Eif4ebp1

Etv5

Page 21: R Graphics Output - Harvard Universitypklab.med.harvard.edu/ruslan/neural_crest/Data S2.pdfMark1 Slc2a1 Gprc5a Sema3a Chrdl1 Zyx Col14a1 Naaa Aprt Cenpv Bmper Boc Scrn1 Ptprz1 Prr5l

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Sox10

Ets1

Rasa3

Erbb3

Arpc1b

Tmc6

Tspan7

Plp1

Cdc42se1

Sppl2b

Pxn

Dpysl3

Mical1

Cnp

Ttyh2

Dab1

Igsf3

Arhgap28

Gsta4

Cmtm5

Tnik

Erbb2

Robo1

Itga6

Cdc42ep1

Acot1

Tes

Rhbdf1

Klhl21

Ndfip1

Npr3

Mtap

Timm10b

Rac1

Arhgef26

Abcg2