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Place of Birth:............................... Pirna, Saxony, Germany Citizenship:.................................. US (naturalized in March, l958) Military Service:........................... US Air Force, 1962-1967; Pilot, Vietnam Veteran EDUCATION: B.S. (l962)............................... Stevens Institute of Technology, Hoboken, N.J.; Major: Engineering Physics Ph.D. (l973)............................... Florida State University, Tallahassee, Florida;

Major: Neurophysiology and Biophysics Postdoctoral Training.............. Experimental Neuropathology Section,

(Feb. l974-Feb. l977) Max Planck Institute for Psychiatry, Munich, Germany. PROFESSIONAL EXPERIENCE Research Associate Experimental Neuropathology Section, (Feb. l976-Aug. l977) Max Planck Institute for Psychiatry, Munich, Germany. Visiting Research Scientist Preclinical Research Division, Sandoz Ltd., (Aug.1977-Dec.1977) Basel, Switzerland Assistant Professor Department of Biology, Texas Woman's University, Denton, TX (Jan l978-Aug l98l) Associate Professor Department of Biology, Texas Woman's University, Denton, TX (Sept. 1981-Aug.1985) Associate Professor Dept. of Biological Sciences, North Texas State University, Denton, TX (Sept. 1985-Aug. 1988) Professor of Neuroscience Dept. of Biological Sciences, University of North Texas (Sept. 1, 1988 - present) (formerly North Texas State University) Director of the UNT Center for Network Neuroscience..................……….. Jan. 1,1987 - present Regents Professor of Neuroscience......................................................……. Sept.1,1996 - present Teaching Experience

Undergraduate Courses: Neurophysiology and Anatomy, Human Anatomy and Physiology, Animal Physiology, Freshman Biology. Primary Course at UNT: Biol 3800, Animal Physiology. Graduate Courses: Lasers in Cell Biology, Biophysics of Excitable Membranes, Photobiology, Electrophysiology, Neurobiology, Theoretical Neuroscience, Cellular Neuroscience, Systems Neuroscience.

Other: Instructor pilot: 4410th Combat Crew Training Squadron, Hurlburt Fld, Fla.

Home Address 1051 Turquoise Lane Oak Point, TX 75068 Home Telephone ((214) 407-6133 Cell Phone: (940) 300-3525 Private e-mail: gwgross@suddenlink.net

E-Mail and Website gwgross@.unt.edu gwgross@cnns.org Center Website: www.cnns.org

Guenter W. Gross, Ph.D. Regents Professor of Neuroscience Department of Biological Sciences Regents Professor of Neuroscience Department of Biological Sciences University of North Texas,

1155 Union Circle, #305220 Denton, TX 76203-5017

Office: 940-565-3615 Lab: 940-565-4228 FAX: 940-565-4136 Update: November, 2014

R E S U M E

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1. SUMMARY of RESEARCH ACTIVITIES

GENERAL RESEARCH DOMAIN: Cellular and Network Neurophysiology SPECIFIC RESEARCH AREAS: (1) Internal Dynamics of Small Mammalian Nerve Cell Networks: pattern generation, recognition, and storage; fault tolerance (2) Cell-Electrode Coupling and Cell Adhesion to Artificial Surfaces. (3) Multichannel Recording and Life-Support Technology for Cell Culture. (4) Theory of Network Self-Organization (5) Applied Neuronal Network Dynamics to (a) Neurotoxicology & Pharmacology (b) Drug Development (c) Tissue-Based Biosensors (d) Pharmaceutical Biotechnology PRESENT MAJOR RESEARCH EFFORT: Neuronal Network Applications (Biosensors, Pharmacology, Toxicology). Development of Multinetwork Platforms for Rapid Parallel Assays. Modeling of Network Dynamics Network-network interactions ACTIVE COLLABORATIONS Plexon Inc., Dallas, TX. Development and testing of data acquisition and processing hardware and software. Development of 8-network high throughput recording/assay platforms. Technical University of Munich, Germany; Professor Dr. Bernhard Wolf. Integrated pH, osmolarity, and impedance sensors for networks in culture; magnetic stimulation of neurons in culture with emphasis on subthreshold effects. Will terminate in May of 2016 with the retirement of Prof. B. Wolf.

University of Rostock, Germany, Dr. Alexandra Gramowski, Department of Zoology. Response reproducibility of neuronal networks on microelectrode arrays to pharmacological compounds. University of North Texas, Department of Speech and Hearing Sciences Dr. Kamakshi Gopal and Dr. Ernest Moore Pharmacology and toxicology of auditory cortex networks University of North Texas, Department of Physics Prof. Paolo Grigolini and PhD student Nicola Piccinini. Theoretical network dynamics; complex networks, network/network interactions

Afferent Knowledge Consulting Company, Barcelona, Spain www.afferentk.com Dr. Enric Claverol, Chief Executive Officer Life support systems for in vitro research platforms 3Brain GmbH. Landquart. Switzerland www.3brain.com Mauro Gandolfo, CEO , High density microelectrode systems. Transition to parallel, multiwell platforms for high throughput pharmacology and toxicology.

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2. RESEARCH SUPPORT $8,403,136 ($7,450,085 at UNT) as of Sept. 1, 2015)

A. Institutional and State of Texas ($1,429,881) ($1,369,671 at UNT) 1978-1985 $ 60,210 Institutional Research Grants, Texas Woman's University 1986-1987 $ 550,000 Texas Advanced Technology Research Grant 1987-1988 $ 3,500 Institutional Research Grant, North Texas State University 1987-1988 $ 14,000 NTSU Decker Scholar Award 1990-1992 $ 391,355 Texas Advanced Research Program:"Internal dynamics,

self-organization, and fault tolerance of small nerve cell networks". 1990-1992 $ 200,000 Texas Advanced Technology Program. "Applied Neuroelectronics". 1992-1994 $ 245,000 Texas Advanced Technology Program "A marketable flow chamber for long-term recording, and optical monitoring 1997-1998 $ 3,500 Institutional Research Grant, University of North Texas 1/04 – 8/06 $200,000 Texas Advanced Technology Program /TDT: +$200,000 Rapid, parallel pharmacological screening using multiple neuronal networks on microelectrode arrays (+ equal in-kind matching from Plexon Inc., Dallas). Total support $400,000 9/08-9-2010 Texas Advanced Research Program: “Antibody-conjugated carbon $30,000 nanotubes for selective photothermal ablation of human tumors”. (to UNT) PI: Rockford Draper, UTD; Co-PI at Southwestern: EllenVitetta Co-PI at UNT: Guenter W. Gross (Total $150,000). 09/01/2009 $ 7,316 Research Opportunity (ROP) Proposal, University of North Texas 08/31/2010 “Differential Sensitivity of Cancer Cells to Zinc Toxicity” 9/1/13-8/31/14 $10,000 UNT ROP: Photonic stimulation of neurons using laser pulses 9/1/15-8/31/16 $10,000 UNT Research Seed Grant Synaptic damage after impact injury: Quantification of deficits and strategies for recovery enhancement.

B. Federal Grants (Principal Investigator unless otherwise noted) ($5,111,477) ($4,728,636 at UNT) 1979-1982 $ 105,513 NIH-NINCDS 1980 $ 3,000 NIH- Fogarty International Center 1982-1984 $ 139,061 NIH-NINCDS 1984-1987 $ 205,773 NIH-NINCDS 1987-1990 $ 252,213 NIH-NINCDS 1991-1993 $ 220,000 ONR (CoPI; Dr. Stephen Fracek, PI) 9/1/91-8/19/94 $ 377,000 NIH-NINDS In vitro studies of acute phase trauma interventions 9/1/94-8/31/98 $ 867,000 NIH-NINDS (Co-PI; Dr. Jen Lucas, PI at Ohio State) In vitro tests of acute spinal cord injury treatment strategies (NS29683). 11/1/94-10/31/96 $ 61,185 NFS subcontract through SMU (Howard/Gosney, P.I.s)

Development of a VLSI system for improved monitoring and stimulating of neuronal networks (NSF BIR9317891)

4/15/99-3/31/02 $ 832,465 DARPA Tissue Based Biosensor Program Neuronal Network Responses to Neuroactive Agents: Determination of Response Reliability, Confidence Limits, and Threat Assessment from Multichannel Data.

8/1/01- 5/31/03 $ 710,915 DARPA: Activities Detection Technologies Program. "Development of a generic, broad-band neuronal network biosensor with emphasis on water monitoring". Contract No. N66001-01-C-8049 9/01-9/03 $ 350,000 NIH, National Center for Complementary and Alternative Medicine Chapman/Gross/Venables; Application R21 AT00358 Kent Chapman, Project Director Natural sources of neuroactive N-acyl ethanolamines, 8/01/03-10/31/03 $ 140.000 JVAP (Joint Vaccine Acquisition Program), Fort Detrick, MD.

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Botulinum Toxin Assays in vitro using neuronal networks. 1/0/05-12/31/07 $ 167,352 Los Alamos National Laboratory, Co P.I., Luis Bettencourt, P.I. Quantitative modeling of living neural networks in vitro 09/01/10 – 08/31/12 $ 339,000 (UNT) DARPA (total contract: $2,080,000) Centers in Integrated Photonics Research (CIPhER): RA 09-35

“Neurophotonics Research Center: a focused collaboration developing a complete neurophotonic interface”

RESEARCH COMPONENTS P.I. Marc Christensen SMU Electrical Engineering/Photonics Co-P.I. M. Volkan Otugen SMU Mechanical Engineering/sensor development Co-P.I. Guenter W. Gross UNT Neurophysiology/ Sensor Evaluation with MEAs Co-P.I. Duncan MacFarlane UTD Engineering/Microfabrication Co-P.I. Dustin Tyler CWRU Animal implants Co-P.I. Duco Jansen Vanderbilt Photonic neural stimulation Co-P.I. Anita Mahadevan Vanderbilt Implant verification

C. Foundation Support: ($1,337,326) 1986 & 1987 $ 13,000 COMMUNITIES FOUNDATION OF TEXAS: NTSU symposia: "Networks in Brain and Computer Architecture". 6/1/87-5/31/88 $ 200,000 COMMUNITIES FOUNDATION OF TEXAS: W.W. Caruth Grant in "Neuroelectronics"; a joint NTSU/SMU effort. 6/1/88-5/32/89 $ 220,000 COMMUNITIES FOUNDATION OF TEXAS: "Neuroelectronics"; 6/1/89-5/31/92 $ 519,326 HILLCREST FOUNDATION: " Network Pathology: Application of new electrophysiological and laser cell surgery technologies to investigations of brain dysfunction" November 1990 $ 100,000 Charles Bowen Endowment for Neuroscience Research 6/1/92-5/31/93 $ 50,000 HILLCREST FOUNDATION: support for CNNS technical staff. 6/1/93-5/31/94 $ 50,000 HILLCREST FOUNDATION: support for CNNS technical staff 9/1/94 $ 10,000 COMMUNITIES FOUNDATION: support for liposome project 11/97- 4/99 $ 120,000 HILLCREST FOUNDATION, Hogan-Boyd Trust for Mental Retardation $ 55,000 purchase of Zeiss microscope

D. Industrial Support: ($84,452) 1978-1982 $ 15,000 Sandoz A.G., Basel, Switzerland. Dec. '82 $ 55,000 Sandoz A.G., Basel, donation of UV laser microbeam system 6/89 - 12/89 $ 14,452 Texas Instruments Grant "Burst pattern recognition and classification with neural networks”

E. CNNS Sales of MEAs and Recording Chambers [MEA: microelectrode array] 1997 to 2013 $ 309,442

3. PROFESSIONAL ACTIVITIES

A. EDITORIAL ACTIVITIES 1. Editorial Board of "Neural Networks" (1998-2008) (a) Action Editor for Neural Networks (b) Action Editor for Neural Network Letters 2. Associate Editor, Frontiers in Neuroengineering (2010-present) 3. Associate Editor, Journal of Neurotrauma (1989-1993)

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4. Recent Editorial Assignments (2015) Computational Intelligence and Neuroscience (Hindawi Corporation) Lead Guest Editor for a special journal series: "Internal Network Dynamics" (with Enric Claverol, Barcelona; Jaap van Pelt, Amsterdam, and Paolo Grigolini, UNT/Denton B. PROFESSIONAL ORGANIZATIONS American Society for Neuroscience International Neural Network Society Sigma Xi C. HONORS Decker Scholar, University of North Texas, 1992 Bart Memorial Research Fellow of the University of Nottingham 1996-1998 Guest Professor, University of Rostock, Germany, 1996-2002 UNT Regents Professor, September 1997- present. Guest Professor, Technical University of Munich, 2003 - 2016 Opening Lectures in a new “Neural Engineering Program ” 5 –day lecture series University of Catalonia, Barcelona, Spain Invited to write Scholarpedia article on “ Microelectrode Arrays” (Curator)

4. PUBLICATIONS and PRESENTATIONS

A. ARTICLES PUBLISHED 1. Beidler, L.M. and Gross, G.W. (l97l). The nature of taste receptor sites. In: Contributions to Sensory

Physiology, V.5, W.D. Neff (Ed), Academic Press, N.Y.; 97-127. 2. Gross, G.W. and Beidler, L.M. (l973). Fast axonal transport in the C-fibers of the garfish olfactory nerve.

J. Neurobiol. 4: 413-428. 3. Gross, G.W. (l973). A quantitative characterization of rapid axoplasmic transport in the C-fibers of the

garfish olfactory nerve. Ph.D. Dissertation, Florida State University, Tallahassee, Florida. 4. Gross, G.W. (l973). The effect of temperature on rapid axoplasmic transport in C-fibers. Brain Res. 56:

359-363. 5. Gross, G.W. and Beidler, L.M. (l975). A quantitative analysis of isotope concentration profiles and rapid

transport velocities of the C-fibers of the garfish olfactory nerve. J. Neurobiol. 6: 213-232. 6. Gross, G.W. (l975). The microstream concept of axoplasmic and dendritic transport. In: Physiology and

Pathology of Dendrites, Advances in Neurology 12, G.W. Kreutzberg (Ed.), Raven Press, N.Y.: 283-296. 7. Gross, G.W. (l975). Rapid axoplasmic transport in C-fibers: An analysis of macromolecule-bound

isotope concentration distributions. In: Recent Advances in Myology, W.G. Bradley (Ed.), Excerpta Medica, Amsterdam: 195-205.

8. Gross, G.W. and Weiss, D.G. (l977). Subcellular fractionation of rapidly transported axonal material in

olfactory nerve: evidence for size-dependent molecule separation during transport. Neurosci. Lett. 5: 15-20.

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9. Kreutzberg, G.W. and Gross, G.W. (l977). General morphology and axonal ultrastructure of the olfactory nerve of the pike, Esox lucius. Cell. Tiss. Res. 181: 443-457.

10. Rieske, E., Gross, G.W. and Kreutzberg, G.W. (l977). Laser in der experimentellen Zellforschung. In:

Laser and Elektro-Optik 2: 44-45. 11. Gross, G.W., Rieske, E., Kreutzberg, G.W. and Meyer, A. (l977). A new fixed-array multimicroelectrode

system designed for long-term monitoring of extracellular single unit neuronal activity in vitro. Neurosci. Lett. 6: 101-105.

12. Gross, G.W. and Kreutzberg, G.W. (l978). Rapid axoplasmic transport in the olfactory nerve of the pike:

I. Basic transport parameters for proteins and amino acids. Brain Res. 139: 65-77. 13. Weiss, D.G., Krygier-Brevart, V., Gross, G.W. and Kreutzberg, G.W. (l978). Rapid axoplasmic transport

on the olfactory nerve of the pike: II. Analysis of transported proteins by SDS gel electrophoresis. Brain Res. 139: 77-89.

14. Gross, G.W. (l979). Simultaneous single unit recording in vitro with a photoetched laser deinsulated gold

multi-microelectrode surface. IEEEE Trans. Biomed. Eng. BME-26: 273-279. 15. Higgins, M.L., Smith, M.N. and Gross, G.W. (l980). Selective cell destruction and precise process

transection in neuroblastoma cultures with pulsed UV laser microbeam irradiation: an analysis of mechanism and transection reliability with light and scanning electron microscopy. J. Neurosci. Meth. 3: 83-99.

16. Gross, G.W., Stewart, G.H. and Horwitz, G. (l98l). Molecular diffusion cannot account for spreading of

isotope distribution peaks during rapid axoplasmic transport. Brain Res. 216: 215-218. 17. Gross, G.W., Williams, A.N. and Lucas, J.H. (l982). Recording of spontaneous activity with photoetched

microelectrode surfaces from mouse spinal neurons in culture. J. Neurosci. Meth. 5: 13-22. 18. Gross, G.W. and Weiss, D.G. (1982). Theoretical considerations on rapid transport in low viscosity

axonal regions. In: Axoplasmic Transport (D.G. Weiss, ed.) Springer Verlag, Heidelberg. 330-341. 19. Weiss, D.G. and Gross, G.W. (1982). The microstream hypothesis: Characteristics, predictions and

compatibility with data. In; Axoplasmic Transport (D.G. Weiss, ed.) Springer Verlag, Heidelberg. 362-383.

20. Stewart, G.H., Horwitz, B. and Gross, G.W. (1982). A chromatographic model of axoplasmic transport.

In: Axoplasmic Transport (D.G. Weiss, ed.) Springer Verlag, Heidelberg. 414-421. 21. Gross, G.W. and Lucas, J.H. (1982). Long-term monitoring of spontaneous single unit activity from

neuronal monolayer networks cultured on photoetched multielectrode surfaces. J. Electrophys. Tech. 9: 55-69.

22. Weiss, D.G. and Gross, G.W. (1983). Intracellular transport in nerve cell processes: The chromatic

dynamics of axoplasmic transport. In: Biological Structures and Coupled Flows (A. Oplatka, ed.) Academic Press, N.Y. pp. 387-396.

23. Weiss, D.G. and Gross, G.W. (1983). Intracellular transport in axonal microtubular domains. I.

Theoretical considerations on the essential properties of a force-generating mechanism. Protoplasma 114: 179-197.

24. Gross, G.W. and Weiss, D.G. (1983). Intracellular transport in axonal microtubular domains. II. Velocity

profile and energetics of circumtubular flow. Protoplasma 114: 198-209. 25. Gross, G.W., Lucas, J.H., and Higgins, L.M. (1983). Laser microbeam surgery: ultra-structural changes

associated with neurite transection in culture. J. Neuroscience 3: 1979-1993. 26. Weiss, D.G. and Gross, G.W. (1983) Intracellular transport in nerve cell processes: The chromatographic

dynamics of axoplasmic transport. In: Biological Structures and Coupled Flows (A. Oplatka and M. Balaban, eds). Academic Press, pp. 387-396.

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27. Kirkpatrick. J.B., Higgins, M.L., Lucas, J.H. and Gross, G.W. (1985). Neural trauma simulation by laser in

vitro. J. Neuropath and Exp. Neurol. 44: 268-284. 28. Lucas, J.H., Kirkpatrick, J.B. and Gross, G.W. (l985). A photoetched matrix for cell relocation in culture

and histology. J. Neurosci. Meth. 14: 211-219. 29. Hightower, M.H. and Gross, G.W. (l985). A combined Bodian-Nissl stain for improved network analysis in

neuronal cell culture. Stain Technol. 60: 315-320. 30. Gross, G.W., Wen, W. and Lin, J. (l985). Transparent indium-tin oxide patterns for extracellular, multisite

recording in neuronal cultures. J. Neurosci. Meth. 15: 243-252. 31. Lucas, J.H., Gross, G.W., Emery, D.G. and Gardner, C.R. (l985). Neuronal survival after dendrite

transection close to the perikaryon. Central Nervous System Trauma. 2: 231-255. 32. Lucas, J.H., Czisny, L.E. and Gross, G.W. (l986). Adhesion of cultured mammalian CNS neurons to

flame-modified hydrophobic surfaces. In Vitro. 22: 37-43. 33. Droge, M.H., Gross, G.W., Hightower, M.H. and Czisny, L.E. (l986). Multielectrode analysis of

coordinated, rhythmic bursting in cultured CNS monolayer networks. J. Neuroscience 6: 1583-1592. 34. Gross, G.W. and Higgins, M.L. (l987). Cytoplasmic damage gradients in dendrites after transection

lesions. Exp. Brain Res. 67: 52-60. 35. Emery, D.G., Lucas, J.H., and Gross, G.W. (l987). The sequence of ultrastructural changes in cultured

neurons after dendrite transection. Exp. Brain Res. 67: 41-51. 36. Gross, G.W. and Hightower, M.H. (l987). An approach to the determination of network properties in

mammalian neuronal monolayer cultures. Proceedings of the First IEEE Conference on Synthetic Microstructures in Biological Research (M.C. Peckerar, S.A. Shamma, and R.J. Wyatt, eds.) Naval Research Lab Press.

37. Gross, G.W. and Hightower, M.H. (1987) Multielectrode investigations of network properties in neural

monolayer cultures. Proc. of the 6th Southern Biomed. Eng. Conf., pp. 212-217. 38. Kowalski, J.M., Ansari, A., Prueitt, P., Dawes, R., and Gross, G.W. (1988) Coupled rotators as a model for spontaneous activity in neural networks. Proc. 1988 MIDCON Tech. Conf., Dallas. pp 11-13. 39. Kowalski, J.M., Ansari, A., Prueitt, P., Dawes, R., and Gross, G.W. (1988) On synchronization and

phase locking in strongly coupled systems of planar rotators. Complex Systems 2: 441-462. 40. Lucas, J.H., Gross, G.W., Trump, B.F., Balentine, J.D., Berezesky, I.K., Young, W., Gilad, G.M., and

Bernstein, J.J. (1988) An International Symposium: Cellular and Molecular Correlates of Central Nervous System Trauma; J. Neurotrauma 5: 209-234.

41. Turkle-Huslig, T., Carter, S.J., Howard, L., and Gross, G.W. (1989) Stability of impedance characteristics

at the microelectrode-saline interface. Proc. of the Ann. IEEE Int. Conf. in Medicine and Biology Society, Seattle, WA., pp. 1427-1428.

42. Vithalani, P.V., Abuzaid, M.A., Gosney, W.M., Howard, L.L., and Gross, G.W. (1989) A sixteen-channel

CMOS analog preamplifier chip for monitoring and stimulating action potentials of cultured neurons. Proc. 8th Southern Biomed. Eng. Conf., Richmond, VA. pp 118-121.

43. Shi, Ri-Yi, Lucas, J.H., and Gross G.W. (1989) Calcium antagonists fail to protect mammalian spinal

neurons after physical trauma. J. Neurotrauma, 6: 261-276. 44. Marchman, H., Howard, L.L., and Gross, G.W. (1989) The application of fiber-optic pH sensing systems

to cultured neuronal network media. Proc. Eighth So. Biomed. Eng. Conf., Richmond, VA., pp 114-117.

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45. Gross, G.W., Kowalski, J.M., and Golden, D. (1990) On the behavior and significance of random neuronal networks. Proceedings of the International Joint Conference on Neural Networks, Washington, Vol 1, pp 86-89.

46. Lucas, J.H., Wang, G., and Gross, G.W. (1990) Paradoxical effect of hypothermia on survival of lesioned

and uninjured mammalian spinal neurons. Brain Research 517: 354-357 47. Kowalski, J.M. and Gross, G.W. (1990) Coupled relaxational oscillators as a model of spontaneous

activity in neuronal networks. Proceedings of the International Joint Conf. on Neural Networks, Paris, Vol 1, pp 488-491.

48. Lucas, J.H., Emery, J.D., Higgins, M.L., and G.W. Gross (1990) Neuronal survival and dynamics of

ultrastructural damage after dendrotomy in low calcium. J. Neurotrauma 7: 169-192. 49. Lucas, J.H., Wang, G., and Gross, G.W. (1990) NMDA antagonists prevent hypothermic injury and death

of mammalian spinal neurons. J. Neurotrauma 7: 229-236. 50. Kowalski, J.M., Albert, G.L., and Gross, G.W. (1990) On the asymptotically synchronous chaotic orbits in

systems of excitable elements. Physical Review A, 42: 6260-6263. 51. Gross, G.W. and Kowalski, J.M. (1991) Experimental and theoretical analyses of random network

dynamics. In: Neural Networks, Concepts, Application and Implementation, Vol. 4 (Antognetti and Milutinovic, eds), Prentice Hall, N.J., pp 47-110.

52. Emery, D.G., Lucas, J.H., and Gross, G.W. (1991) Contributions of sodium and chloride to ultrastructural

damage after dendrotomy. Exp. Brain Res. 86: 60-72. 53. Abuzaid, M.A., Vithalani, P.V., Howard, L., Gosney, W.M., and Gross, G.W. (1991) A VLSI peripheral

system for monitoring and stimulating action potentials of cultured neurons. Proc. of the 1st Great Lakes Symp. on VLSI, Kalamazoo, MI., pp. 170-173.

54a. Gross, G.W., Rhoades, B.K., and Jordan, R.J. (1992) Neuronal networks for biochemical sensing.

Sensors and Actuators B, 6: 1-8. 54b. Gross, G.W., Rhoades, B.K., and Jordan, R.J. (1992) Neuronal networks for biochemical sensing.

Proceedings of Eurosensors V , Vol 1 (A. D'Amico, ed.) pp 1-8. 55. Kowalski, J.M., Albert, G.L., Rhoades, B.K., and Gross, G.W. (1992) Correlated spontaneous activity in

cultured neuronal networks as possible manifestations of synchronized chaos. In: Proceedings of 1st Conference on Experimental Chaos, Arlington VA. (S. Vohara, M. Sapano, M. Schlesinger, L. Pecora, and W. Ditto eds.), World Scientific, Singapore; pp. 213-218.

56. Kowalski, J.M., Albert, G.L., Rhoades, B.K., and Gross, G.W. (1992) Neuronal networks with

spontaneous, correlated bursting activity: theory and simulations. Neural Networks 5: 805-822. 57. Tai, J-D., Gosney, W. M., Howard, LL., and Gross, G.W. (1992) An algorithm and its implementation for

neural spike-burst-pattern recognition. Proceedings of the '92 Conference on Artificial Neural Networks in Engineering. Vol 2, pp 457-462; ASME Press, N.Y.

58. Tai, J-D., Gosney, W. M., Howard, LL., and Gross, G.W. (1992) Real-time neural pulse pattern feature

extraction and recognition. 35th Midwest Symposium on Circuits and Systems, Vol. 2, pp 1527-1529. 59. Gross, G.W., Rhoades, B.K., and Kowalski, J.M. (1993) Dynamics of burst patterns generated by

monolayer networks in culture. In: Neurobionics (H.W. Bothe, M. Samii and R. Eckmiller, eds) Elsevier, Amsterdam , pp.89-121.

60. Gross, G.W., Rhoades, B.K., Reust, D.L., and Schwalm, F.U. (1993) Stimulation of monolayer networks

in culture through thin film indium-tin oxide recording electrodes. J. Neurosci. Meth. 50: 131-143. 61. Gross, G.W. (1994) Internal dynamics of randomized mammalian neuronal networks in culture. In:

Enabling Technologies for Cultured Neural Networks (D.A. Stenger and T.M. McKenna, eds), Academic Press, N.Y. pp 277-317.

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62. Tam, D.C. and Gross, G.W. (1994) Extraction of dynamical changes in neuronal network circuitries using

multi-unit spike train analysis. In: Enabling Technologies for Cultured Neural Networks (D.A. Stenger and T.M. McKenna, eds), Academic Press, N.Y.

63. Azzazy, H.M., Gross, G.W., and Wu, Ming-Chi (1994) Production and characterization of antibodies

against C-terminal peptide of protein F1: a novel phosphorylation at serine 209 of the peptide by protein kinase C. Neurochemical Research 19: 275-282.

64. Lucas, J.H., Emery, D.G., Wang, G., Rosenberg-Schaffer, L.J., Jordan, R.S., and Gross, G.W. (1994) In

vitro investigations of the effects of nonfreezing low temperatures on lesioned and uninjured mammalian spinal neurons. J. Neurotrauma 11: 35-61.

65. Rhoades, B.K. and Gross, G.W. (1994) Potassium and calcium channel dependence of bursting in

cultured neuronal networks. Brain Research 643: 310-318. 66. Gross, G.W. and Schwalm, F.U. (1994) A closed chamber for long-term electrophysiological and

microscopical monitoring of monolayer neuronal networks. J. Neuroscience Methods 52: 73-85. 67. Gross, G.W. and Tam, D.C. (1994) Pre-conditional correlation between neurons in cultured networks.

Proceedings of the 1994 World Congress on Neural Networks, San Diego; Vol. 2, pp. 786-791. 68. Tam, D.C. and Gross, G.W. (1994) Post-conditional correlation between neurons in cultured neuronal

networks. Proceedings of the 1994 World Congress on Neural Networks, San Diego; Vol. 2, pp. 792-797. 69. Gross, G.W., Azzazy, H.M.E., Wu, M-C, and Rhoades, B.K.(1995) The use of neuronal networks on

multielectrode arrays as biosensors. Biosensors and Bioelectronics 10: 553-567. 70. Lucas, J.H., Emery, D.G., and Gross, G.W. (1995) Tissue culture study of neuronal responses to physical

lesions of the plasma membrane: environmental influences and experimental interventions. In: Central Nervous System Trauma: Research Techniques (S.T. Ohnishi and T. Ohnishi, eds), CRC Series in Membrane-Linked Diseases, CRC Press, Ann Arbor, pp 353-373.

71. Azzazy, H.M.E., Hong, K., Wu, M-C, and Gross, G.W. (1995) Interaction of cationic liposomes with cells

of electrically active neuronal networks in culture. Brain Research 695: 231-236. 72. Rhoades, B.K., Weil, J.C., Kowalski, J.M., and Gross, G.W. (1996) Distribution-free graphical and

statistical analysis of serial dependence in neuronal spike trains. J. Neurosci. Meth. 64: 25-37. 73. Gopal, K.V. and Gross, G.W. (1996) Auditory cortical neurons in vitro: Cell culture and multichannel

extracellular recording. Acta Otolaryngologica, 116: 690-696. 74. Gopal, K.V. and Gross, G.W. (1996) Auditory cortical neurons in vitro: Initial pharmacological studies.

Acta Otolaryngologica, 116: 697-704. 75. Rosenberg, L., Jordan, R.S., Gross, G.W., Emery, D.G., and Lucas, J.L. (1996) Effects of

methylprednisolone on lesioned and uninjured mammalian spinal neurons: viability, ultrastructure and network electrophysiology. J. Neurotrauma 13: 417-437.

76. Gross, G.W., Harsch, A., Rhoades, B.K., and Göpel, W. (1997) Odor, drug, and toxin analysis with

neuronal networks in vitro: extracellular array recording of network responses. Bisosensors & Bioelectronics 12: 373-393.

77. Gross, G.W., Norton, S., Gopal, K., Schiffmann, D., and Gramowski, A. (1997) Nerve cell network in vitro:

Applications to neurotoxicology, drug development, and biosensors. In: The Neuro-Electronic Interface. Cellular Engineering 2: 138-147.

78. Bogdan, M., Harsch, A., Gross, G.W., Göpel, W., and Rosenstiel, W. (1997) Processing of nerve cell

signal recordings from cultured networks using artificial neural nets. 1997 Proceedings of the IASTED on Artificial Intelligence and Soft Computing, Banff, Canada.

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79. Gross, G.W. and Kowalski, J.M. (1998) Emergent dynamical properties of biological neuronal ensembles and their theoretical interpretation and significance. In: Computing Anticipatory Systems, (D.M. Dubois, ed) AIP Conf. Proc. 437: 577-594.

80. Calderon, J.G., Harsch, A., Gross, G.W., and Timmons, R. (1998) Stability of plasma polymerized

allylamine films towards sterilization via autoclaving. J. of Biomed. Mater. Res. 42: 597-603. 81. Gross, G.W. (1998) Emergent Properties of Self-Organizing Nerve Cell Ensembles in Culture. Proc. of the

4th Internat. Conf. on Intelligent Materials, Tokyo, Japan. pp 326-329. 82. Gross, G.W., Kowalski, J.M. and Rhoades, B.K. (1999) Spontaneous and evoked oscillations in cultured

neuronal networks. In: Oscillations in Neural Systems (D. Levine, V. Brown, T. Shirey, eds) Erlbaum Assoc., N.Y.pp 3-29.

83. Gross, G.W. and Kowalski, J.M. (1999) Origins of activity patterns in self-organizing neuronal networks in

vitro. Journal of Intelligent Material Systems and Structures 10: 558-563. 84. Gramowski, A., Schiffmann, D., and Gross, G.W. (2000) Quantification of acute neurotoxic effects of

trimethyltin using neuronal networks cultured on microelectrode arrays. NeuroToxicology 21: 331-342. 85. Morefield, S. I., Keefer, E.W., Chapman, K. D., and Gross, G.W. (2000) Drug evaluations using neuronal

networks cultured on microelectrode arrays. Biosensors and Bioelectronics 15:383-396. 86. Harsch, A., Calderon, J., Timmons, R. B, and Gross, G.W. (2000) Pulsed plasma deposition of

allylamine on polysiloxane: A stable surface for neuronal cell adhesion. J. Neuroscience Methods 98: 135-144.

87. Keefer, E.W., Norton, S.J., Boyle, N.A.J., Talesa, V., and Gross, G.W. (2001a) Acute toxicity screening of

novel AChE inhibitors using neuronal networks on microelectrode arrays. NeuroToxicology 22 (1): 3-12. 88. Stenger, D.A., Gross. G.W., Keefer, E.K., Shaffer, K.M., Andreadis, J.D., Wu Ma, and Pancrazio, J.J.

(2001) Detection of physiologically active compounds using cell-based biosensors. Trends in Biotechnology 19: 304-309.

89. Pancrazio, J.J., Keefer, E.W., Wu Ma, Stenger, D.A., and Gross, G.W. (2001) Neurophysiologic

evaluation of chemical agent hydrolysis products on cortical neurons in vitro. NeuroToxicology 22: 393-400.

90. Keefer, E.K., Gramowski, A., Stenger, D.A., Pancrazio, J.J., and Gross, G.W. (2001b) Characterization of

acute neurotoxic effects of trimethylolpropane phosphate via neuronal network biosensors. Biosensors and Bioelectronics 16: 513-525.

91. Keefer, E.W., Gramowski, A., and Gross, G.W. (2001c) NMDA receptor dependent periodic oscillations in

cultured spinal cord networks. J. Neurophysiol. 86: 3030-3042. 92. J Loock, J Stange, S Mitzner, R Schmidt, E W Keefer, G W Gross (2001) Influence of albumin dialysis

(MARS) on neuronal network activity in vitro. Zeitschrift Fur Gastroenterologie - Z Gastroentrol 01/2001; 39: 40-40. DOI:10.1055/s-2001-919046.

93. Chapman, K.D., Venables, B.J., Dian, E.E., and Gross, G.W. (2003) Identification and quantification of neuroactive N-Acylethanolamines in cottonseed processing fractions. JAOCS V80, #3, 223-229.

94. O’Shaughnessy, T. J., Zim, B., Wu Ma , Shaffer, K. M., Stenger, D. A. Zamani, K., Gross, G. W.,

Pancrazio, J. J.(2003) Acute neuropharmacologic action of chloroquine on cortical neurons in vitro. Brain Research 959 (2003) 280–286.

95. Xia, Y., Gopal, K.V., and Gross, G.W. (2003) Differential acute effects of fluoxetine on frontal and

auditory cortex networks in vitro. Brain Research, 973: 151-160. 96. Pancrazio J.J., Gray S.A., Shubin Y.S., Cuttino D.S, Shaffer K.M., Eisemann K, Curran A, Zim B, Gross

GW, O'Shaughnessy TJ. (2003) A portable microelectrode array recording system incorporating cultured neuronal networks for neurotoxin detection. Biosensors & Bioelectronics 18: 1339-1347.

11

97. Xia, Y. and Gross, G.W. (2003) Histiotypic electrophysiological responses of cultured neuronal networks

to ethanol. Alcohol 30: 167-174. 98. Ignaccolo, M., Grigolini P., and Gross, G.W. (2003) Towards the timely detection of toxicants. Chaos,

Solitons and Fractals 20: 87-93. 99. Selinger, J., Pancrazio, J.J., and Gross, G.W. (2004) Measuring synchronization in neuronal networks for

biosensor applications. Biosensors and Bioelectronics: 675-683. 100. Gramowski, A, Juegelt, K., Weiss, D.G., and Gross, G.W. (2004) Substance identification by quantitative

characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays. European J. Neurosci., 19: 2815-2825.

101. Gopal, K.V. and Gross, G.W. (2004) Unique responses of auditory cortex networks in vitro to low concentrations of quinine. Hearing Research 192: 10-22.

102. Turnbull, L. and Gross, G.W. (2005) The string method of burst identification in neuronal spike trains. J. Neurosci. Meth. 145: 23-35.

103. Gross, G.W., Dian, E., Keefer, E.W., Gramowski, A., and Stuewe, S. (2005) Long-term functional

contact between nerve cell networks and microelectrode arrays. In (Berger, T. and Glanzman, D., eds.) Toward Replacement Parts for the Brain. The MIT Press, pp 177-203.

104. Gross, G.W and Gopal, K.V. (2006) Emerging histiotypic properties of cultured neuronal networks. In:

M. Taketani and M. Baudry (eds) Advances in Network Electrophysiology using Multi-Electrode Arrays. Springer, pp 193-214.

105. Gross, G.W., Rijal-Oli

, S., Jones, V, Hollmuller, D., and Karg, M. (2006) High throughput

microelectrode array platforms for quantitative pharmacology and toxicology. Proceedings of MEA 2006, BIOPRO, Baden-Wuerttemberg. pp 132-135.

106. Ressler, J., Grothe, H., Brischwein, M., Ilchmann, F., Karg, M., Gross, G.W., and Wolf, B. (2006)

Combining the recording of neural activity with metabolic parameters: Sensorchips with MEA and integrated sensors for oxygen, pH, and temperature. Proceedings of MEA 2006, BIOPRO, Baden-Wuerttemberg. pp 157-160.

107. Gross

, G.W., Parviz, M. Ham, M., and Karg

, M. (2006) Nerve Cell Networks on Microelectrode Arrays:

High Throughput Platforms for Pharmacology, Toxicology, and Neuroinformatics. Proceedings of Medical Electronics Conference, 2006: Silicone Meets Medicine. Technical University of Munich. 108. Shafer, T.J., Rijal-Oli, S. and Gross,

G.W.

(2006)

Deltamethrin and permethrin decrease spontaneous

activity in neuronal networks in vitro. Proceedings of MEA 2006, BIOPRO, Baden-Wuerttemberg. pp149-150.

109. Meyer, J.F. and Gross, G.W. (2006). Magnetic stimulation and depression of non-homogenous networks in primary neuronal cell cultures. Proceedings of MEA 2006, BIOPRO, Baden-Wuerttemberg.

110. Gramowski A, Stuewe S, Juegelt K, Schiffmann D, Loock J, Schroeder O, Gross GW, Weiss DG. (2006) Detecting neurotoxicity through electrical activity changes of neuronal networks on multielectrode neurochips. ALTEX. 2006; 23 Suppl:410-5.

111. Gross, G.W. and Pancrazio, J.P.P. (2007) Neuronal Network Biosensors. In: Smart Biosensor Technology (G.K. Knopf and A.S. Bassi, eds), Taylor and Francis Publishers, CRC Press.pp 177-201.

112. Parviz, M. and Gross, G.W. (2007). Quantification of zinc toxicity using neuronal networks on microelectrode arrays. NeuroToxicology 28(3): 520-531.

113. Bettencourt L.M, Stephens, G.J., Ham, M., and Gross, G.W. (2007). Functional structure of cortical neuronal networks grown in vitro. Physical Reviews E 75, 021915:1-10.

12

114. Gopal, K.V. Miller, B.R., and Gross, G.W. (2007) D-methylphenidate-induced reduction of spontaneous activity in Auditory and Frontal Cortex Networks In Vitro. J. of Neural Transmission;114(11):1365-1375.

115. Ham, M., Bettencourt, L. M., McDaniel, D, and Gross, G.W. (2008). Spontaneous coordinated activity in

cultured networks: Analysis of multiple ignition sites, primary circuits, and burst phase delay distributions. J. Computational Neuroscience 24: 346-357.

116. Shafer, T. J, Rijal, S.O., and Gross, G.W. (2008). Complete inhibition of spontaneous activity in neuronal

networks in vitro by deltamethryn and permethryn. NeuroToxicology 29: 203-212. 117. Edward W. Keefer, Barry R. Botterman, Mario I. Romero, Andrew F. Rossi, and Guenter W. Gross

(2008) Carbon nanotube coating improves neuronal recordings. Nature Nanotechnology 3, 434 - 439 (01 Jul 2008).

118. Rijal-Oli, S. and Gross, G.W. (2008) Determination of dissociation constants using spontaneous

neuronal network activity recorded with microelectrode arrays in vitro. Journal of Neuroscience Methods 173 (2008) 183–192.

119. Ham, M.I., Gintautas, V., and Gross, G.W. (2008) Spontaneous coordinated activity in cultured networks:

Analysis of multiple ignition sites, primary circuits, burst phase delay distributions, and functional structures. Proceedings of the 6

th International Meeting on Substrate-Integrated Micro Electrode Arrays.

pp. 29-32. 120. Nicoletti, M., Meyer, J.F., Wey, T., Kinney, T., Ilchmann, F., Gross, G.W., and Wolf, B. (2008) Coil

design optimization for magnetic stimulation of neural tissue cultures on MEAs. Proceedings of the 6th

International Meeting on Substrate-Integrated Micro Electrode Arrays. pp 168-169. 121. Keefer, E. and Gross, G.W. (2008) Modifying metal electrodes with carbon nanotubes. Proceedings of

the 6th International Meeting on Substrate-Integrated Micro Electrode Arrays. p 314.

122. Meyer, J.M., Wolf, B., and Gross, G.W. (2009) Magnetic stimulation and depression of mammalian

networks in primary neuronal cell cultures. IEEE Biomedical Engineering. Vol 56, No.5, 1-12.

123. Johnstone, A.F.M., Gross G.W., Weiss

, D.G., Schroeder

, O., Gramowski, A.

and Shafer, T.J. (2010)

Micro-electrode Arrays: A Physiologically-based Neurotoxicity Testing Platform for the 21st Century.

NeuroToxicology 31: 331–350.

124. Bozym RA, Chimienti F, Frederickson CJ, Giblin LJ, Gross GW, Korichneva I, Li J, Libert S, Maret W, Parviz M, Thompson RB (2010) Free Zinc Outside a Narrow Range is Toxic to a Variety of Cells in vitro. Experimental Biology and Medicine 235: 741–750.

125. Gross GW (2011) Multielectrode Arrays. Scholarpedia, 6(3): 5749

126. Novellino A, Scelfo B, Palosaari T, Price A, Sobanski T, Shafer TJ, Johnstone AFM, Gross GW, Gramowski A, Schroeder O, Jügelt K, Chiappalone M,Benfenati F, Martinoia S, Tedesco MT, Defranchi E, D'Angelo P, Whelan M. (2011) Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals. Frontiers in Neuroengineering, V4:4: 1-14.

127. Wu

C,

Gopal

KG,

Gross

GW,

Lukas

JT,

Moore EJ (2011) An in vitro model for testing drugs to treat

tinnitus. European Journal of Pharmacology. DOI: 10.1016/j.ejphar.2011.05.070

128. Gopal KG, Wu C, Moore E, Gross GW (2011) Assessment of styrene oxide neurotoxicity using in vitro auditory cortex networks, J. Otolaryngology. Doi:10.5402/2011/204804 129. Gross GW (2012) Bioelectronic Screening in Vitro. In (B. Wolf, ed) Bioelektronische Diagnose- und

Therapiesysteme. Shaker Verlag, ISBN: 978-3-8440-0831-9.

130. Gopal KV, Wu C, Shresta B, Campbell KCM, Moore EJ, Gross GW (2012) D-methionine protects against cisplatin-induced neurotoxicity in cortical networks. Neurotoxicology and Teratology, Volume 34, Issue 5: 495-504.

13

131. Gopal KV, Wu C, Shrestha

B, Moore

EJ, Gross

GW (2012) Acute Quantification of Cisplatin Toxicity and

Protection by D-Methionine. Proceedings of the 8th International Conference on Microelectrode Arrays,

July 2012,pp 179-180; NMI, Reutlingen, Germany. 132. Moore

EJ, Wu

C, Gopal

KV, Lukas

TJ, Gross GW (2012). Assay for Drugs to Treat Tinnitus.

Proceedings of the 8th International Conference on Microelectrode Arrays, July 2012, pp 169-170. NMI,

Reutlingen, Germany. 133. Wu

C, GopaL

KV, Moore

EJ, Gross

GW (2012) Antioxidants D-Methionine and L-Carnitine Modulate

Neuronal Activity through GABAergic Inhibition. Proceedings of the 8th International Conference on

Microelectrode Arrays, July 2012, pp 181-182. NMI, Reutlingen, Germany. 134. Bennett RA, Perez

J, Gross

GW (2012) Photonic stimulation of neurons in vitro at 337.1 nm.

Proceedings of the 8th International Conference on Microelectrode Arrays, July 2012, pp 194-197. NMI,

Reutlingen, Germany. 135. Pancrazio JP, Keefer E, Gopal K, Gross GW (2014) Botulinum Toxin Suppression of CNS Network

Activity In Vitro. Journal of Toxicology , vol. 2014, Article ID 732913, 10 pages. doi:10.1155/2014/732913.

136. Calvin Wu

C, Gopal

KV, Moore

EJ, Gross

GW (2014) Antioxidants L-carnitine and D-methionine

modulate neuronal activity through GABAergic inhibition. J. Neurotransmission. DOI 10.1007/s00702-014-1170-x

137. Wu

C, Gopal K, Lukas TJ, Gross GW, Moore EJ (2014) Pharmacodynamics of Potassium Channel

Openers in Cultured Neuronal Networks. European Journal of Pharmacology 732: 68-75. 138. Holmes

KE, Smith DC, Gross GW (2014) Cytotoxicity of the antimalarial drug mefloquine and novel

protection by quinolinic acid. Proceedings of the 9th International Meeting on Substrate Integrated Microelectrode Arrays. 109-111.

139. Calderon NK , Ledee D, Gopal K, Gross GW (2014) Cortical Networks Respond with Major Activity Changes to Sildenafil Citrate (Viagra). Proceedings of the 9th International Meeting on Substrate

Integrated Microelectrode Arrays. 116-117. 140. Smith DC, Gross GW (2014) An MEA-Based Model for Rapid Acceleration Injury to Neuronal Networks and Studies of Recovery. Proceedings of the 9th International Meeting on

Substrate Integrated Microelectrode Arrays. 156-157. DOI: 10.13140/RG.2.1.4395. 141. Claverol-Tinture E, Gross GW (2015) Feedback, preservation of spike timing and brain evolution. A

comment on: “Feedback stabilizes propagation of synchronous spiking in cortical neural networks” by Moldakarimov, S., Bazhenov, M., and Sejnowski, T.J. (2015) Proc Natl Acad Sci U S A 112, 2545-255 Article ID: 150379.

142. Hamilton KS, Gopal KV, Moore EJ, Gross GW (2016) Pharmacological Response Sensitization in

Nerve Cell Networks Exposed to the Antibiotic Gentamicin. European Journal of Pharmacology (under review). Manuscript Number: EJP-44453

Articles in Preparation Gross, G.W., Keefer, E.W, and Wiggins, H. Problems associated with high throughput, parallel multinetwork recording system. J. Neuroscience Methods.

14

C. ABSTRACTS PUBLISHED (~ 210 total) Hamilton, K., Gopal, K.V., Moore, E.J., and Gross, G.W. (2015). Gentamicin Alters the Sensitivity of GABAA Receptors in Cultured Auditory Cortex Networks. Published Abstract. Association for Research in Otolaryngology 38th Annual Midwinter Meeting, Baltimore, MD. Vol 38 page 40, abstract # 84. Rogers EA, Gross GW (2016) Network Trauma: Electrophysiological and subcellular damage after tangential

300-600g impacts in vitro. Society for Neuroscience Abstract, Nov. 2016, San Diego, CA

D. PATENTS 1. P 26 38 276.3, February, l977. Optische Blende und damit ausgerüstete Laseroptische Einrichtung E. Remy & G.W. Gross. 2. P 27 41 638.2 ; (U.S patent 4,231,660 ) Nov. 1979. Microscope slide with electrode arrangements for cell study and method for its construction. G.W. Gross, A. Meyer, E. Remy, E. Rieske , Note: Non-exclusive rights to patent purchased by Panasonic (Matsushita Electric, Japan) in November of 1996. 3. Patent # 02735058.6-2404-DE0201609; Jan 27, 04 University of Rostock School of Medicine (Dr. Jan Loock et al)

Verfahren zur Extrakorporalen qualitativen und/oder quantitativen Erfassung neurotoxischer substanzen im Blutplasma eines Individuums. “Method for in vitro qualitative and/or quantitative determination of neurotoxic substances in the plasma of individuals”.

4. UNT technology 10GG-2005-09; title “Multinetwork Nerve Cell Assay Platform With Parallel Recording Capability” USPTO patent number 8,460,921 issued on 6/11/13.

E. INVITED LECTURES - 1986-2003 (1974 - 1985: ~ 20) 1. February 19, l986 Ohio State University School of Medicine, Spinal Cord Trauma Center: "Reaction of neurons to dendrite amputation trauma within 400 µm of the soma." 2. February 20, l986 IBM, Watson Research Laboratory, Yorktown Heights, N.Y. "Network properties of neural monolayer cultures on photoetched, multimicroelectrode plates." 3. February 26, l986 Acoustic, Speech and Signal Processing Society, IEEE Special Interest Group, Dallas Chapt. "Analysis of cultured networks with fixed matrix multielectrode patterns and laser cell surgery." 4. March 23-26, l986

Conference: Synthetic Microstructures in Biological Research; sponsored by the Office of Naval Research, IEEE, Nat. Inst. of Mental Health. "Analysis of Neuronal Networks in Culture with Transparent, Thin Film, Indium-Tin Oxide Multielectrode Patterns."

5. March 26, l986 BDM Corporation, Arlie, Virginia "Multielectrode Analysis of Network Properties in Neuronal Cell Culture"

15

6. March 27, l986 Department of Physiology, Medical College of South Carolina "Multielectrode Analysis of Network Properties in Neuronal Cell Culture" 7. April 11, l986 Department of Zoology, Iowa State University, Ames "Multielectrode Analysis of Network Properties in Neuronal Cell Culture" 8. May 26, l986 AT&T Bell Labs, Murray Hill, N.J. "Multielectrode Analysis of Network Properties in Neuronal Cell Culture" 9. December 1, 1986 Department of Biochemistry, Texas College of Osteopathic Medicine, Fort Worth "Network Analysis in Neuronal Monolayer Cultures" 10. April 2, 1987 Department of Psychology, Michigan State University "Pattern Generation in Neuronal Monolayer Networks" 11. April 26-28, 1987 Lloyd M. Beidler Symposium on Taste and Olfaction, Florida State U.,

Tallahassee "Network Analysis in Culture: Pattern Generation in Olfactory and Spinal Tissues" 12. June 18, 1987 Neural Modeling Minisymposium at UTA, Arlington TX "New Approaches to the Correlation of Network Structure and Function" 13. October 12, 1987 Department of Electrical Engineering, SMU, Dallas, TX "Multielectrode Investigations of Neural Network Properties in Cell Culture" 14. October 24, 1987 Sixth Southern Biomedical Engineering Conference, Dallas TX. Invited to organize and chair the "Neural Networks Session" 15. November 13, 1987 Denton Sigma-Xi "CNS Network Feature Extraction via Burst Pattern Analysis" 16. January 5, 1988 MIT- Lincoln Laboratories (Special DARPA Meeting on Neural Network Research) "Significance of

Network Research on Mammalian Central Nervous System Preparations to Neural Modeling" 17. March 28, 1988 Department of Physiology, School of Medicine, University of North Carolina, Chapel Hill, N.C.

"Network Feature Extraction via Multielectrode Burst Pattern Analysis in Cell Culture". 18. September 6 - 10, 1988 International Neural Network Society "Network Feature Extraction via Multielectrode Burst Pattern Analysis in Cell Culture" (invited presentation). 19. April 3 - 7, 1989 British Society for Experimental Biology, Edinburgh Meeting Bioelectronics and Biosensors Session, "Simultaneous recording from multielectrode arrays."

16

20. April 11, 1989 Technical University of Munich, Garching, Germany "Investigation of neuronal network dynamics in cell culture." 21. July 17, 1990 Institute for Medical Psychology, Univ. of Munich, "Experimental analyses of internal network dynamics." 22. July 23, 1990 GBF - Gesellschaft für Biotechnologische Forschung, Braunschweig, Germany; Experimental analyses of internal network dynamics." 23. July 25, 1990 Institute for Neurobiology and Brain Research, GDR Academy of Sciences, Magdeburg, Germany "Experimental analyses of internal network dynamics." 24. October 2, 1990 University of Illinois, Department of Physiology and Biophysics and Beckman Research Center "Internal network dynamics: the struggle for pattern generation in ensembles of nerve cells" 25. Dec 20, 1990: Oregon Health Sciences University, Portland; Department of Neurosurgery "Internal network dynamics: pattern generation and storage within assemblies of neurons in culture". 26. June 6, 1991 IBM, Charlotte, N.C. Neuronal network dynamics: studies of pattern generation, pattern storage and fault tolerance in small nerve cell networks 27. Sept. 30, 1991 Eurosensors V Conference, Rome, Opening Plenary Lecture "Neuronal networks for biochemical sensing" 28. February 28 to March 1, 1992 International Workshop on Neurobionics, Goslar, Germany Plenary Lecture: " Dynamics of burst patterns generated by monolayer networks in culture" Chaired two sessions: Feb 29th AM: Biotechnical Connection; March 1, AM: Biotechnical Interfacing in Sensorimotor Control 29. March 19 and 20, 1992 Tenth Annual Houston Conference on Biomedical Engineering Research March 20, AM: "Technical developments in multichannel recording" March 20, PM: "Pattern generation in cultured monolayer neuronal networks" 30. April 25 - 28, 1992 Controlled Growth and Communication in Cultured Mammalian Neurons; Naval Research Laboratory, Washington, D.C. "Spontaneous and evoked burst pattern dynamics generated by monolayer networks in culture." 31. November 19, 1992 Electrochemical Society, North Texas Local Section, Dallas. "Information processing: from networks to brain systems" 32. March 17 -20, 1993

Neurotronics Workshop; Fraunhofer Institute, Saarbrücken, Germany "New Approaches to the Study of Internal Network Dynamics"

17

33. March 17-20, 1994 Center for Biological Timing, University of Virginia "Internal Network Dynamics" 34. May 5-7, 1994 Conference on Oscillations in Neural Systems, University of Texas at Arlington "Spontaneous and Evoked Oscillatory Bursting States in Cultured Networks" 35. May 25, 1994 Department of Physiology, Ohio State University Medical School "Multiunit Investigations of Internal Network Dynamics in Mammalian CNS Monolayer Cultures with Applications to Neuropathology and Neurotoxicology" 36. June 2-3, 1994 1994 World Congress on Biosensors, New Orleans Neuronal networks on multielectrode arrays: utilization of changes in spontaneous network dynamics to express genetically-engineered supersensitivities to specific chemical compounds. Chaired one session. 37. October 3-5, 1994 Daimler Benz Corporate Workshop on "Biological Systems for Technology" Stuttgart, Germany 38. October 7-9, 1994 Department of Zoology, University of Rostock, Germany "Internal network dynamics" 39. October 14-16, 1994 1994 Annual Fall Meeting of the Biomedical Engineering Society, Arizona State University "Biosensor properties of neuronal networks in culture" 40. February 16-17, 1995 13th Annual Houston Conference on Biomedical Engineering Research "Biosensor properties of neuronal network dynamics" Chaired one session 41. May 5, 1995 German Ministry for Science and Technology; Special Status Reports on "Bioelectronics" VDI-Technology Center, Berlin: "Neuroelectronics" 42. July 23-28, 1995 Gordon Conference on Biocompatibility and Stabilization of Cell Phenotype, Holderness, NH. "Long-term stability of morphological characteristics, cell electrode coupling, spontaneous burst 4 pattern generation, and pharmacological responses in murine monolayer networks in culture. 43. September 8-15, 1995 Rostock University, Germany Participation in a defense of a major new research program in "Complex Cellular Biosensors" before the German Research Council (Deutsche Forschungsgemeinschaft; DFG) 44. October 12-13, 1995" Clemson University, S.C., Department of Bioengineering

"Long-term maintenance of neuronal networks on multielectrode arrays in culture: problems of cell-surface interactions."

45. February 21, 1996 Purdue University, School of Veterinary Medicine, Center for Paralysis Research

18

"Brain Democracy in Action: Pattern generation in mammalian nerve cell groups" 46. May 23-July 10, 1996 University of Rostock, Germany, Department of Zoology (a) Teaching: neuronal networks: theory and practice (b) Consultant: construction of cell culture and photolithography facilities (c) Research Planning: Complex cellular biosensors 47. June 26, 1996 University of Tübingen, Germany

(a) Wilhelm Schickard Institut für Informatik, Department of Computer Engineering "Self-assembly of spontaneously active networks in vitro" (b) Institut für Physikalische and Theoretische Chemie "Pharmacological responses of networks in vitro.

48. July 12, 1996 BASF GmbH, Ludwigshaven, Germany "Rapid, high volume neurotoxicity prescreening of chemicals with neuronal networks in vitro." 49. July 15, 1996 Glaxo-Wellcome, London, UK

"Screening for neuroactive and neurotoxic compounds with cultured, spontaneously active neuronal networks."

50. July 16, 1996 University of Nottingham, England, Department of Physiology and Pharmacology Bart Memorial Research Fellow of the University of Nottingham "Applications of neuronal network dynamics" 51. October 7, 1996 190th Meeting of the American Electrochemical Society Opening Plenary Lecture "Eves-dropping on neuronal networks with photoetched microelectrode arrays" 52. April 28, 1997 Purdue University, School of Veterinary Medicine Applications of network dynamics to neurotoxicology, drug development, and biosensors. 53. June 25, 1997 Humboldt University, Berlin, Germany Neuronal network dynamics in cell culture: Applications to neurotoxicology, drug development, and biosensors. 54. August 11-15, 1997 First International Conference on Computing Anticipatory Systems Liege, Belgium Emergent Dynamic Properties of Biological Neuronal Ensembles. 55. September 8-12, 1997 Dreiländertagung für Elektronenmikroskopie, Regensburg, Germany "Neuronal networks on multielectrode chips: self-organization of electrically active networks and applications to neurotoxicology and neuropharmacology." 56. October 24, 1997 CNTC Symposium: New Developments in Multichannel Recording and Stimulation (NIH-sponsored satellite symposium to the annual Neuroscience Meeting, New Orleans) "Multielectrode arrays in cell culture: Platforms for the study of network dynamics and self- organization". 57. December 8-9, 1997

19

DARPA Workshop on Cell and Tissue Biosensors, Washington D.C. "Application of neuronal network dynamics to biosensors" 58. April 21-25, 1998 Analytica '98, Munich, Germany, Medical Technology "Rapid screening for neurotoxicity with neuronal networks on microelectrode arrays." 59. May 24 & 25, 1998 1998 Human Anatomy & Physiology Society (HAPS) Conference, Ft. Worth "Neuronal networks growing on microelectrode arrays: Applications to neurotoxicology, drug development, and biosensors. 60. August 28, 1998 Department of Chemistry and Biochemistry, University of Texas at Arlington "Nerve cell networks in culture: Simplified histiotypic representations of the parent tissue." 61. October 5-7, 1998 4th International Conference on Intelligent Materials, Tokyo, Japan "Emergent properties of self-organizing nerve cell ensembles in culture" 62. January 17-22, 1999 Gordon Research Conference on Electrochemistry, Ventura, CA. "Nerve cell networks growing on microelectrode arrays in culture: Self-organization and electrophysiological dynamics." 63. March 14-18, 1999 German Society for Cell Biology Annual Meeting, Rostock "Neuronal networks in vitro: platforms for biosensor functions, and screening of drugs and chemicals" 64. March 19, 1999 Technical University Dresden, Germany, Institut für Werkstoffwissenschaft "Nerve cell networks growing on microelectrode arrays in culture: Self-organization, electrophysiological dynamics, and emergent properties". 65. June 21-23, 1999 DARPA Workshop No 2 on Tissue-Based Biosensors, New Bern, N.C. "Neuronal network responses to neuroactive agents: response reliability, confidence limits, and threat assessment". 66. June 24, 1999 Biomedical Engineering and Department of Anatomy and Neuroscience University of Texas Medical Branch, Galveston

"Neuronal network dynamics in vitro in vitro : Application to Neurotoxicology, Drug Development, and Tissue-Based Biosensors."

67. August 12-14, 1999

NIMH/USC-AMI WORKSHOP, Washington, D.C: Replacement Parts for the Brain: Intracranial Implantation of Hardware Models of Neural Circuitry,

"Long-term coupling of monolayer neuronal networks to multielectrode arrays in culture" 68. October 8, 1999 Department of Chemistry, University of North Texas, "Tissue-Based Biosensors: Rapid Alert Systems for Unknown Toxic Agents." 69. December 21, 1999 Department of Pharmacology, University of North Texas Health Science Center "Neuronal networks growing on substrate-integrated microelectrode arrays: Applications to drug development, toxicology, and biosensors." 70. April 9-14, 2000 DARPA, Joint Two-Program Meeting Controlled Biological and Biomimetic Systems and Tissue-Based Biosensors

20

71. May 19-20, 2000 Krasnow Institute, George Mason University Nonlinear Synchronization in Neuroscience, NIH-Sponsored Workshop "Origins of activity patterns in self-organizing networks cultured on microelectrode arrays." 72. June 12, 13, 14, 15, 2000 Institute for Zoology, Rostock University (Germany) Four invited lectures on nerve cell network physiology and application (scheduled classes). 73. June 21 - 23, 2000 University of Tübingen, NMI 2nd International Workshop on Substrate-Integrated Microelectrode Arrays.

Keynote Address: Neuronal networks growing on substrate-integrated microelectrode arrays. New applications to drug development, neurotoxicology, and biosensors.

74. Sept 7-9, 2000 Second International Meeting on Biomedicine and Medical Technology, Rostock, Germany Plenary Address: "Neuronal Network Biosensors in Defense and Medicine" 75. February 8-10, 2001 DARPA Tissue-Based Biosensors and Advanced Diagnostics Principal Investigator Conference. Neuronal network biosensors: detection, classification, identification. 76. May 17, 2001 Center for Disease Control (Atlanta). Special DARPA/CDC seminar series: Matured DARPA technologies in the Tissue-Based Biosensor Program "Neuronal Network Biosensors". 76. June 4-5, 2001 USAMRIID Meeting, Fort Detrick, MD "Neuronal Network Biosensors". 76. June 27-30, 2001 Cell-Surface Coupling. An international workshop sponsored by the Max Planck Society Schloss Ringberg, Tegernsee, Germany

"Long-term functional contact between nerve cell networks and microelectrode arrays allows applications to toxicology, drug development, and biosensors.

77. February 18-21, 2002 DARPA, Tissue-Based Biosensors Program Principal Investigators Meeting, Miami Beach "Recent Progress in Neuronal Network Biosensors at UNT" 78. June 24-25. 2002 NIH, Bethesda MD; BECON Conference (Bioengineering Consortium) Panel member in Cell Based Sensing workshop. 79. September 12-14, 2002

International Conference and Exhibition: Biosystems, Bioengineering, Biotechnology, Rostock, Germany Plenary Lecture: “Spontaneously active neuronal networks on microelectrode arrays: applications to toxicology, drug development, and biosensors.”

80. Sept 17-18, 2002 Technical University of Munich (Prof. Dr. Bernhard Wolf, host.) ”Technical challenges of multichannel recording from networks in vitro.” 81. November 2, 2002

Society for Neuroscience Satellite Symposium, Olando, Fla., Developments in Multichannel Recording VI. Sponsor: University of Michigan Center for Neural Communication Technology

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David J. Anderson, Organizer "Performance of Neuronal Networks on Microelectrode Arrays as Tissue Based Biosensors".

82. May 2, 2003

JVAP: Joint Vaccine Acquisition Program, Fort Detrick, MD “Neuronal network assays for botulinum toxins and their antibodies.”

83. July 7-11, 2003 Technical University of Munich, 3 classroom lectures and 1 seminar 84. July 15, 2003 University of Duesseldorf School of Medicine “Neuronal networks on microelectrode arrays: applications to toxicology, drug development, biosensors,

and basic neuroscience.” 85. October 3-6, 2003 Los Alamos National Laboratory Lecture 1. “Internal Network Dynamics: Mathematical and Theoretical Challenges.” Lecture 2. “Neuronal Network Biosensors” 86. Nov 17, 2003

Brookhaven Biological Science Symposium “Neuronal Networks on Microelectrode Arrays: Applications to Pharmacology, Toxicology, and Biosensors.”

87. May 31 – June 3, 2004 German Zoological Society, Rostock Meeting "Neuronal networks on microelectrode arrays: applications to toxicology and biosensors" 88. July 6-9, 2004 Simea 2004; 4

th International Conference on Substrate-Integrated Microelectrodes

Member of Organizing Committee; Chair of 1 session “Neuronal Networks on Passive Microelectrode Arrays: Emerging Histiotypic Nature of Pharmacological Responses.” 89. July 12-16, 2004 Technical University of Munich, Germany Guest Professor Lectures on network dynamics, applications, and methods 90. September 10, 2004 University of North Texas; Department of Biological Sciences Seminar, (UNT)

“Neuronal Networks on Microelectrode Arrays: Emerging Histiotypic Nature of Pharmacological Responses“

91. September 14, 2004-09-12 University of Texas at Dallas, Bionanotech Group “Neuronal Networks on Microelectrode Arrays: Present Status and Future Potential.“ 92. March 23 and 24, 2005 Environmental Protection Agency, Research Triangle Park, NC “Neuronal Networks on Microelectrode Arrays: applications to toxicology screening and biosensors.“ 93. June 13-17, 2005 Technical University of Munich, Institute for Medical Electronics„ VDE Lecture Series (Verband der Elektrotechnik, Elektronik, Informationstechnik) „Lab on a Chip: Nerve Cell Networks on Microelectrode Arrays in vitro.“ 94. December 5-8, 2005 IBRCC 2005: Interagency Botulism Research Coordinating Committee Meeting.

High throughput assay and analysis platforms using neuronal networks cultured on microelectrode arrays.

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95. February 203, 2006

JSPS – UNT Joint Symposium on Nanoscale Materials for Optoelectronics and Biotechnology Neuronal networks on microelectrode arrays: nanoscaled biosensor, research, and assay platforms.

96. April 28, 2006

Distinguished Speaker Series, UTA-NanoFab and IEEE-Electron Devices Society. Neuronal networks on microelectrode arrays: nanoscaled biosensor, research, and assay platforms.

97. June 28, 2006

Munich Symposia on Medical Electronics: “Microelectronics Meets Medicine” "Brain Tissue on Chips: High throughput-Platforms für Neuropharmakologie und Neuroinformatik"

98. July 4-7, 2006 5

th International Conference on Microelectrode Array Recording (Reutlingen, Germany)

High throughput microelectrode array platforms for quantitative pharmacology and toxicology. 99. July 31, 2006

Bernstein Center for Computational Neuroscience, Munich, Germany „Nerve cell networks on microelectrode arrays: A window to the internal dynamics of mammalian brain tissue.“

100. November 13-14, 2006

ICCVAM/NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce, or Replace the Mouse LD50 Assay for Botulinum Toxin Testing" ;Silver Spring, Maryland. Quantification of BoNT-A Activity Suppression in Neuronal Networks Growing on Microelectrode Arrays in vitro.

101.February 19-21, 2007 Grand Challenges in Neural Computation, Santa Fe, N.M. Center for Nonlinear Studies, Los Alamos National Laboratory. “Nerve cell networks on microelectrode arrays: platforms for investigations of neuronal dynamics underlying information processing.” 102. May 30 – June 7, 2008 Technical University of Catalonia, Barcelona Establish and give the first lectures of a one-week course in “neuroengineering”

Contact: Dr. Enric Claverol-Tinturé Head of Neural Engineering Lab Catalonia Institute for Bioengineering (IBEC) Baldiri i Reixac, 15-21; 08028 Barcelona (Spain)

103. June 9-June 30, 2008 Technical University of Munich (TUM) (a) 3 seminars and several informal lectures for the Nixdorf Division for Medical Electronics (b) one 3-day mini-symposium on microelectrode array recording and applications with the Institute for Biomedical Engineering (IMETUM) (c) Research on magnetic stimulation of networks in lab set up during a two-month visit in 2006. 104. July 1, 2008 Technical University of Dresden, Germany Max Bergmann Center for Biomaterials (Dr. Michael Mertig, Host)

“Neuronal networks on microelectrode arrays: Recent Progress and Challenging Applications” 105. October 20 –22, 2008

Workshop: Toxicology Protocol Standardization for Microelectrode Array Research European Commission- DG Joint Research Centre, Ispra (VA) Italy Institute for Health and Consumer Protection, Dr. Tomasz Sobanski (host)

106. October 31, 2008 Southern Methodist University, Dallas, Department of Electrical Engineering.

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Nerve cell networks on microelectrode arrays: a window to the internal dynamics of neuronal ensembles and a new platform for rapid toxicity screening, pharmacological assays, and drug development.

107. November 21, 2008 Department of Bioengineering, University of Texas at Arlington “The dynamics of neuronal ensembles: Theory and applications for engineers”. 108. September 7-12, 2009 World Congress on Medical Physics and Biomedical Engineering Munich, Germany Keynote Address: Theme 8: Micro and Nanosystems in Medicine, Active Implants, and Biosensors.

“High throughput microelectrode array platforms for quantitative pharmacology, toxicology, and drug

development”. 109. November 24, 2009 IEEE Aerospace & Electronic Systems, Dallas Chapter “Neuro-Engineering: New Insights and Applications 110. May 5, 2010 Environmental Protection Agency, Dallas; Region 6 (Drinking Water Section) Seminar: “Spontaneously active nerve cell networks on microelectrode arrays: sensitive and reliable

platforms for quantitative pharmacology, toxicology, and drug development”. 111. June 1-2, 2010 3

rd IBEC Symposium on Bioengineering and Nanomedicine

Technical University of Catalonia, Barcelona, Spain Keynote Speaker: “High throughput microelectrode array platforms for quantitative pharmacology,

toxicology, and drug development using spontaneously active neural tissue.” 112. June 3-4, 2010 Mini-Course in Array Recording from Nerve Cell Networks Technical University of Catalonia, Barcelona, Spain Sponsored by Alleria Biodevices, LLC 113. June 21–23, 2010 39th Neural Interfaces Conference, Long Beach Convention Center, Long Beach, CA. (NIH sponsored) “Validation and Effective Application of in vitro Systems” (invited presentation) 114. October 12-14, 2010 Heinz-Nixdorf-Symposium, Technical University of Munich, BMW Center “In vitro Bioelectronic Screening: Rapid Toxicity Assessments in an Era of Accelerated Chemical and Pharmacological Compound Production.” 115. March 3, 2012 Texas Community College Teachers Association ( TCCTA ), Frisco TX Lecture: Fundamentals of Brain Organization: The intangible nerve cell network 116. July 20, 2012 University of Rostock, Germany Invited by Dr. Olaf Schroeder, CEO NeuroProof Ltd "Cancer Drug Screening with nerve cell networks on microelectrode arrays" 117. June 26, 2014 Technical University of Munich, Invited Seminar: Prof. Bernhard Wolf, host "Computational neuroscience of Traumatic Brain Injury" 118. July 7, 2014

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University of Rostock, Department of Biophysics Invited Seminar: Prof. Jan Giemsa, host "Computational Neuroscience of Traumatic Brain Injury 119. July 7, 2014 NeuroProof, GmbH 2 Invited Seminars, Dr. Olaf Schroeder, host (1) "Cytotoxicity of the Antimalarial Drug Mefloquine and Novel Protection by Quinolinic Acid". (2) "The Intersection of Traumatic Brain Injury and Computational Neuroscience". 120. November 7, 2014 2014 IEEE Medical Device Symposium University of Texas at Dallas, Richardson, TX "Nerve cell networks on microelectrode arrays: quantification and medical application of network dynamics." 121. August 22, 2016 Sigma Xi Initiation Dinner Texas Woman's University, Denton, TX "Cellular and network correlates of traumatic brain injury"

F. MEDIA EXPOSURE January 1987 Scientific American: article, pg 62. 1988 World Book Inc.: "Science Year"; picture of multielectrode plate with monolayer culture & caption.

1989 Eastman Kodak Catalog P-2 : "Photography through the Microscope"; edited by John Gustav Deloy; picture inside front cover, with caption. 1989 GEO Magazine, Hamburg, Germany; repeat of Scientific American photo. 1989 French Scientific Magazine: "Microsystems"; repeat of Scientific American photo and 1/2 page article. June 11, 1987 : Channel 5 news TV coverage June 17, 1987: Cable News Network TV coverage (international coverage) July 7, 1987: Denton cable TV interview Nov. 5, 1987: TWU cable TV interview August, 1991: Material sent to German television network ZDF for inclusion into prime time program on neuroscience research in the '90s. Excerpts of our laboratory research were shown on February 26, 1992 in prime time nationwide by the ZDF Television Network. Fall 1995 OMNI Magazine. Networking the Brain: Tomorrow's computers in a lab dish today. (article by Bennett Daviss) February 2003 Fort Worth Star Telegram

Spring 2014 Denton Record Chronicle. Comrades out of Arms. Dec 24, 2015 9 AM, Radio Interview: KLIF, Dallas "on the neuroscience of concussion"

G. SPECIAL PROFESSIONAL ACTIVITIES (not including reviews of papers, grants, or site visits)

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1980-1981: Member of organizing committee for the First International Workshop on Axoplasmic Transport

held in Bavaria, Germany, April l98l. (Other committee members: A. Dahlstrom, Univ. of Goeteborg; S. Ochs, Univ. of Indiana; J. Schwartz, Columbia Univ.; M. Kurokawa, Univ. of Tokyo; D. G. Weiss, Univ. of Munich.)

January l985: Organizer of AVEC/VIM Workshop at the Texas Woman's University, Denton, TX. Two day

workshop on the Allen Video Enhanced Contrast microscopy and on Video Intensified Microscopy; with equipment demo and utilization.

July 1985: Organizer of Workshop "Networks in Brain and Computer Architecture". A two day meeting of

scientist from local industry and universities with speakers recruited from UC Irvine, UCLA, UC-Berkeley, NIH and NIA. (UNT)

Oct. 1986: Chair of Organizing Committee for the Second Annual Symposium on

"Networks in Brain and Computer Architecture". (UNT) Sept. 1987: Chairman of Organizing Committee for the Third Annual Symposium on

"Networks in Brain and Computer Architecture". (UNT) April 1988: Chair of organizing committee for the first international symposium on "Cellular and Molecular Correlates of Central Nervous System Trauma". (UNT) March 5-10, 03: Chair of Organizing Committee for SIMEA 2003, Denton Texas "Third International

Conference on Substrate Integrated Microelectrode Arrays.” An international conference on multichannel approaches to neuronal dynamics and their applications. (UNT)

July 6-9, 04 Member of Organizing Committee; Chair of 1 session Simea 2004; 4

th International Conference on Substrate-Integrated Microelectrodes

Reutlingen, Germany May 24 – Establishment of a “Neuroengineering Laboratory” at the Technical University of Munich. Aug 16 Personnel training, planning, purchasing, assembly and operation of laboratory. 2006 Personnel training and equipment recommendations started in February of 2006 at the CNNS,

UNT. This laboratory now mirrors some of the capabilities of the CNNS lab at UNT. July 4-7, 06 Member of Organizing Committee; Simea 2006; 5

th International Conference on Substrate-Integrated Microelectrodes

Reutlingen, Germany.

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5. GRADUATE STUDENTS COMPLETED

Date of Degree Student research assignment Graduation.

May 2015 MS Jason Gibson Neurotoxicity of the industrial compound 4-methyl- cyclohexanemethanol: involvement of the GABAA receptor. May 2015 MS Katelyn Holmes Cytotoxicity and Functional Toxicity of the Antimalarial Drug Mefloquine and Search for Protective Compounds. Dec 2014 MS Wei-Jung Tseng Acute effects of the antibiotic streptomycin on neural network activity and on their pharmacological responses. Lab Technician: Pacific Labs, Denton Dec. 2014 MS Meera Sawant Effect of gentamycin on network activity and pharmacological responses to muscimol. Dec 2013 Ph.D. Calvin Wu Networks on MEAs: Realistic Applications to Toxicology. Postdocoral Fellow at the Kresge Hearing Institute, Univ. of Michigan Dec 2010 MA Ryan Bennett Physics/Biology Research: Neurophotonics (McDaniel/Gross) Optical stimulation of neurons in networks Dec 2009 MS Veronica Webb Freezing of adhered neuronal networks Dec 2008 Ph.D. Michael Ham Exploration of hierarchal leadership and connectivity in neural networks in vitro: Origins of spontaneous activity Physics/ neurobiology cross-training; professors: McDaniel & Gross Postdoctoral fellow at Los Alamos National Laboratory Staff Scientist, Los Alamos National Laboratory Dec 2007 M.S. Cara Santa Maria Development of Midbrain Primary Culture on Microelectrode Arrays. Science Reporter, Huffington Post Dec 2007 Ph.D. Florian Matl Technical University of Munich (Prof. Dr. Stemberger) 40% PhD dissertation research completed at UNT (Neurotoxicity of novel antibiotics) Aug 2007 Ph.D. Maryam Parviz Quantification of the Neurotoxicity of Zinc Toxicologist with Alcon Inc., Fort Worth, TX June 2006 MS Michelle Karg, Engineering student; research on biosensors

Tech Univ. Munich and robotic culture life support Jan 27 – June 18; 60% of MS research at UNT

Dec 2005 MS Sabnam Rijal-Oli Pharmacist , Atlanta, GA May 2005 MS Jacob Schwartz PhD Student, UT South Western Medical School March 2005 MS Jochen Meyer, Engineering student, Technical University of Munich Tech. Univ. Munich Magnetic stimulation and inhibition of activity in neuronal networks in vitro. 80% of data for MS obtained at UNT. Dec 2004 MS Benjamin Miller PhD, Indiana University, Bloomington, IN. of Arts and Sciences Neural Science Fellowship Assistant Professor, Schol of Natural Sciences, Texas Wesleyan Univ. Aug 2004 PhD Emese Dian Medical Science Liaison, UCB Pharma Inc., Dallas

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Dec 2003 PhD Ulla Roschier University of Nottingham Medical School (UK) Department of Physiology (80% of research with CNNS)

Aug 2002 MS Yun Xia Senior Research Associate, Pioneer Hi-Bred International

Inc, DuPont, Ames Iowa Dec 2001 Ph.D., Christopher Sparks Postdoctoral appointment with Dr. McMahon, Dept. of Physiology, University of Kentucky Medical Information Scientist, AstraZeneca LP, Houston May 2001 Ph.D., Edward W. Keefer, III. Postdoctoral appointment with Nobel Laureate Dr. Gerald Edelman, The Neuroscience Institute, La Jolla,CA. Senior Research Fellow , UTSWMC, Dallas Dec. 2000 Ph.D Alexandra Gramowski PhD with the University of Rostock (all research at UNT), Research Scientist, U. Rostock Medical School Vice President for Research Neuroproof GmbH, Rostock. Aug. 2000 M.S. Bret Zim Family business, car dealership in Fort Worth. Aug. 1998 M.S., Edward W. Keefer, III. PhD training with the CNNS, UNT May 1998 M.S. Samantha Morefield PhD training in neurobiology, UC Irvine. May 1995 PhD Lisa Rosenberg-Schafer Postdoctoral position, OSU Med. School Res. Asst. Prof. Georgetown Univ., Dept. of Cell Biol. May 1992 MS Amy Wolf PhD Program, Texas Woman’s University; graduated 1996. Aug 1992 MS Rusty Jordan Computer Sciences Corporation Technology Management Group, Fort Worth, Texas May 1991 MS Guofong Wang PhD Program, Ohio State University (Dept. of Physiology) Genetic Screening Service, Denton, TX. May 1990 MS Riyi Shi MD/PhD, Professor at Purdue University Senior Res. Scientist, Center for Paralysis Research Dept. of Basic Medical Sciences School of Veterinary Medicine, Purdue Univ., IN May 1990 MS Richard DeLa Garza Ph.D. University of Texas Medical School at Galveston; Postdoctoral Fellow: Harvard University (>>New England Regional Primate Res. Center) Dec 1988 Ph.D. Mary Hightower Lab Director, Primetox, Inc. Dallas May 1986 Ph.D. Jen Hill Lucas TWU Assistant and Associate Professor Ohio State University Department of Physiology May 1985 Ph.D. Carol Gardner TWU Professor, Rutgers University; Dept. Pharmacol. & Toxicology

May, 1984 Ph.D. Iyad Qassar TWU Pharmacology Lab, Baghdad, Iraq May 1983 MS Brian Feiock TWU TWU >> Medical School, UT Galveston

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6. UNIVERSITY SERVICE ( Sept 1, 1985- present)

DEPARTMENTAL COMMITTEES Department of Biological Sciences Personal Affairs Committee 1987-2003 F 06- 11 Department of Biological Sciences Promotion and Tenure Committee 1988-2001 F06- 10 Department of Biological Sciences Executive Committee 1990, 1996, 2001, 2004 Departmental Search Committee (for neurobiology position) Spring 1992 Departmental Search Committee (for microbiology position) Fall 1994 Departmental Search Committee (for environmental science) Spring 1998 Departmental Search Committee (genetics) Spring 2001 Chair, Dept. Search Committee (for physiology) Spring 2001 Departmental Executive Committee 2005 Graduate Curriculum Committee 2005 Search Committee for Science Education Committee Nov 05-March 06 Biology Search Committee for Evolutionary Biologist Fall 2006 – March 08 Biology Personnel Affairs Committee 2013 - present Biology Promotion and Tenure Committee 2014 - present PAC Criteria Revision Committee S 2015 P&T Criteria Revision Committee S 2015 COLLEGE OF ARTS AND SCIENCES COMMITTEES SRB building representative (with P. Cook -Biochemistry, and E. VanStryland-Physics; Nov. 1985-Dec 1987 C.A.S. Personal Affairs Committee 1991-1993 Space Review Committee (Chair) 1994 - Dec., 1998 Space Review Committee (member) 1994 - 2001 Future of Science Committee 1994 SRB Building Representative 1998 – 2003 College of Engineering “Bioengineering Steering Committee” Fall 2006 – May 07 SRB Building Representative Sept 2012 - present UNIVERSITY COMMITTEES Neuroscience Study Program; (Chair) Federation of North Texas Area Universities Sept. 1986- Sept. 1987 Academic Affairs Committee January - December 1986 Materials Characterization Feasibility Committee (Chair) January - December 1986 UNT Faculty Load Committee 1988, 1989, 1990 UNT Human Subjects Review Committee 1994- 2002 UNT Clean-Room Facilities Committee 2008-2009 UNT Chemical Toxicity Committee (Risk Management) 2014 - present