química bioinorgánica · 2017-06-12 · 99mtc(γ) t 1/2 = 6.03 h spect imaging: intravenous...
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Química Bioinorgánica Introducción General 3
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Estabilidad de iones complejos: Importancia
AgBr + S203-2
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Estabilidad de iones complejos: Importancia
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Ca+2 + EDTA-4 ------> CaEDTA-2
Estabilidad de iones complejos: Importancia
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Estabilidad de iones complejos
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Constantes de estabilidad
+ CO3-2 + NaOH + NaCl
+NH3 +KI
+ Ag+
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Factores que determinan Kf:
M+ L D ML+Δ
K1= [ML] [M][L]
La constante de estabilidad mide la cantidad de calor desprendida y la variación de entropía o desorden.
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Factores que determinan Kf: Efecto iónico
Aumento de carga
KLiOH = 2
KMgOH+ = 100
KYOH+2 = 107
KThOH+3 = 1010
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Factores que determinan Kf: Efecto iónico
Aumento del radio iónico
KBeOH+=107
KMgOH+=120
KCaOH+=30
KBaOH+=4
KYOH+2=107
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KFeF+2=1X106
KFeCl+2=2x101
ClO4-
Kf=???
Factores que determinan Kf: Efecto iónico
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Factores que determinan Kf: E.E.C.C.
[M(H2O)6]2+ + 6X¯ [MX6]4– + 6H2O(l)D
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[M(H2O)6]2+ + 6X¯ [MX6]4– + 6H2O(l)
Factores que determinan Kf: EECC
D
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Ácidos y bases: duros y blandos
H20 vs NH3
Pt, Au, Hg y Pb
Ti, V y Cr
Dureza O>N
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Ácidos y bases: duros y blandos
Baseblando:CN-,I-,Baseduras:NH3,Cl-,F-
Ácidosblandos:Hg,Ag
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Ácidos y bases: duros y blandos
Ag+ + X- AgXD
KAgF = 2
KAgCl = 2X103
KAgBr = 3X104
KAgI = 1X108 ¿Enlace covalente?
¿S?
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Fe2+ + 6CN– ----- [Fe(CN)6]4– K = 1.8 × 106
Fe3+ + 6CN– ----- [Fe(CN)6]3– K = 1.2 × 1031
Ácidos: blandos
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Efecto quelato
Cu+2:
Cu+2
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Efecto quelato
[M(H2O)6]2+(aq) +
+ 6H2O
-2KNi(NH3)6
+2= 1X108
KNiEDTA-2=4,2X1018
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Importancia de la estabilidad de los complejos metálicos
Desferrioxamina (sideroforo natural) Kf = 1031 N
O
OH
CH3
CH3 Deferiprona
Cuprimina®
Remueve Cu que provoca mal de Wilson
Terapias de quelación
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Importancia de la estabilidad de los complejos metálicos
DTPA: agente de contraste paramagnético utilizado para estudios por resonancia magnética.
GaDTPA: K=1X1022
GaEDTA: K= 1X1017
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99mTc(γ) t1/2 = 6.03 h
SPECT imaging: intravenous injection of the γ isotope 99mTc complex for detection of altered regional cerebral perfusion (imaging actual brain function) (Alzheimer's disease)
Importancia de la estabilidad de los complejos metálicos
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Auranofin
Anti-arthritic agentRoxarsone
Aumentar la ganancia de peso y mejorar la eficiencia de la alimentación, y como un coccidiostático (agente antiprotozoario que actúa sobre parásitos coccidios)
Importancia de la estabilidad de los complejos metálicos
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Fin de la clase…