questions for knowledge creators
DESCRIPTION
University of Miami's Clinical and Translational Sciences Institute (CTSI) runs a bootcamp course for medical residents & fellows and postdocs. This is my 2012 version of "Questions for knowledge creators" lecture.TRANSCRIPT
Questions for knowledge creators
richard j. [email protected]
2012 Bootcamp Courseuniversity of miami12 September 2012
disclosures
• I have no financial interest in any of the content presented today.
• I have no direct experience in translational or clinical research
objectives
leave you with questions
How do you pick a problem?
Research is a human activity
http://www.stanford.edu/group/vista/cgi-bin/FOV/wp-content/uploads/2012/02/tables1.png
Which offer do you want?
Which offer do you want?
results
68%16%
32%84%
Dan Ariely, Predictably Irrational
Hypothesis-driven vs.
discovery-driven research
Let’s play a game
basic applied
fundamental
useful
?D.E. Stokes, Pasteur’s Quadrant, 1997
fundamental
useful
From G. Dyson, Turing’s Cathedral, 2012
the internet of things
big bang
the internet of things
big data
^
every
\
http://doi.ieeecomputersociety.org/10.1109/MIS.2009.36
research 3.0de
sign
spe
c
Terms of UseSee this page for info, including copyright
how are these trends playing out in clinical research ??
http://www.patientslikeme.com
http://www.pnas.org/content/105/6/2052
Methods
http://www.pnas.org/content/105/6/2052
http://www.nature.com/nbt/journal/v29/n5/full/nbt.1837.html
AbstractPatients with serious diseases may experiment with drugsthat have not received regulatory approval. Online patient communities structured around quantitative outcome datahave the potential to provide an observational environmentto monitor such drug usage and its consequences. Herewe describe an analysis of data reported on the website PatientsLikeMe by patients with amyotrophic lateral sclerosis (ALS) who experimented with lithium carbonate treatment.To reduce potential bias owing to lack of randomization, we developed an algorithm to match 149 treated patients to multiple controls (447 total) based on the progression of their disease course. At 12 months after treatment, we found no effect of lithium on disease progression. Although observational studies using unblinded data are not a substitute for double- blind randomized control trials, this study reached the same conclusion as subsequent randomized trials,
http://www.nature.com/nbt/journal/v29/n5/pdf/nbt.1837.pdf
http://artisopensource.net/cure/
Salvatore IaconesiFounder, Art is open source
“Patient engagement is the blockbuster drug of the 21st
century”Leonard Kish
http://www.hl7standards.com/blog/2012/08/28/drug-of-the-century/
summary
What problem do you want to work on?
How can you empower patients so as to accelerate discovery?
In a digitally enabled world, can you think of better ways to create useful knowledge?
Are you looking for black swans?
Have you fallen in love with your own ideas?
How does your own brain limit your ability to reason?