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DO NOT OPEN THIS TEST BOOKLET UNTIL YOU ARE TOLD TO DO SO Test Booklet Series Serial No. QUESTION PAPER BOOKLET Time Allowed: Two Hours Maximum Marks: 100 ___________________________________________________________________________________________ ___________________________________________________________________________________________ ___________________________________________________________________________________________ A RC-A

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DO NOT OPEN THIS TEST BOOKLET UNTIL YOU ARE TOLD TO DO SOTest Booklet Series

Serial No.

QUESTION PAPER BOOKLETTime Allowed: Two Hours Maximum Marks: 100

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RC-A3

1. What is water content of lean body tissue ?

A. 51ml/100gram B. 61ml/100gram C. 71ml/100gram D. 81ml/100gram

2. In which body-organ, loose-tight junction is found ?

A. Blood-CSF barrier B. Proximal convoluted tubuleC. Blood-testis barrier D. Thin ascending limb of loop of Henle

3. During cardiac cycle, what is the timing of the opening of the aortic valve ?

A. At the end of isovolumetric contractionB. At the end of isovolumetric relaxationC. At the beginning of isovolumetric contractionD. At the beginning of isovolumetric relaxation

4. Which part of brain is concerned with vestibulo-occular reflex ?

A. spino cerebellum B. flocculonodular lobeC. neocerebellum D. occipital lobe

First urge to void occurs when the urinary bladder contains at least how much volume of urine ?5.

A. 100 ml B.  150 ml C.  250 ml D. 75 ml

6. Urea cycle and kreb cycle are linked at which compound ?

A. Arginate B. Ornithine C. Fumarate D. Oxaloacetate

7. Which of the  following is the primary ketone body?

A. Acetone B. AcetoacetateC. Beta  hydroxy butyric acid D. HMG Co-A

8. Deficiency of aspartoacylase enzyme leads to which disease?

A. Canavan disease B. Buerger’s diseaseC. Caroli Disease D. Hartnup disease

9. In which of the following reaction carbon monoxide is released ?

A. Heme to biliverdin conversionB. Biliverdin to bilirubin conversionC. Bilirubin to bilirubin monoglucuronide conversionD. Bilirubin to bilirubin diglucuronide conversion

10. What is the best method to measure HbA1c ?

A. Isoelectric focusing B. Affinity chromatographyC. Ion exchange chromatography D. Electrophoresis.

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RC-A4

11. Which artery forming Kiesselbach’s plexus is not a branch of External carotid artery:

A. Anterior ethmoidal artery. B.  Sphenopalatine artery.C.  Greater palatine artery. D. Superior labial artery

12. All of the following structures are pierced by the parotid duct except:

A. Buccal pad of fat B. Buccinator muscleC. Pharyngobasilar fascia D. Buccopharyngeal fascia

13. The inter-costobrachial nerve communicate with:

A. Medial brachial cutaneous nerve B. Thoracodorsal nerveC. Long thoracic nerve  D. First intercostal nerve

14. What is length of prostatic urethra ?

A. 4 cm B. 1.5 cm C. 15 cm D. 10 cm 

While removing a fish bone stuck in the throat, the main trunk of internal laryngeal nerve wassevered. The bone was stuck in which part ?

15.

A. Piriform fossa B. Sinus of larynxC. Vallecula epiglottis D. Vestibule of larynx 

16. Wasserman test is:

A. Passive Agglutination test B. Reverse Passive agglutination testC. Complement fixation D. Neutralization test.

17. In D. latum life cycle, choose the second stage larva which develops in cyclops ?

A. Miracidium B. CoracidiumC. Procercoid larva D. Plerocercoid larva

A 29-year-old woman developed an erythema at the insertion site of her intravenous line. Cultureof the catheter tip indicates that a biofilm is present on the catheter. What is the most likelycausative agent ?

18.

A. Staphylococcus aureus B. Staphylococcus epidermidisC. Enterococcus faecalis D. Streptococcus agalactiae

A patient is admitted with pulmonary candidiasis. Blood culture revealed pseudohyphae. Which ofthe following cell types is most likely deficient or dysfunctional in this patient ?

19.

A. T-cells B. B-cells C. Neutrophils D. Phagocytes

A patient is diagnosed with Hepatitis B infection. Which of the following markers will always bepresent in his serum, even during recurrences, or if he develops chronic hepatitis?

20.

A. HBc Ag B. Anti HBs Ab  C. Anti HBc Ab  D. HBe Ag 

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RC-A5

21. Causing death of a woman by illegal abortion is punishable under which IPC section ?

A. 312 B. 313 C. 314 D. 315.

22. Features of strychnine poisoning are all, except ?

A. The convulsions are first clonic and eventually tonicB. Duration of rigor mortis is longerC. All muscles are affected at same timeD. Between fits muscles are completely relaxed

23. Sir Edmund Locard is known for what ?

A. System of personal identification using the body measurementB. Formula for estimation of statureC. Finger print studyD. Poroscopy

24. What is right sequence of putrefaction changes in organs ?

A. Heart – brain – spleen – uterusB. Brain – heart – spleen – uterusC. Spleen – brain – heart – lungsD. Heart – spleen – uterus – brain Solution.

25. Universal antidote includes all except

A. Activated charcoal B.  Magnesium oxideC.  Sodium sulphate D. Tannic acid

26. Which of the following urinary albumin level is defined as micro-albuminuria?

A. 100-150mg/24 hrs B. 151-200mg/24hrsC. 30-300mg/24 hrs D. 301-600mg/24 hrs

Spontaneous non traumatic bleeding can occur when platelet count falls below what number ofplatelets per microlitre ?

27.

A. 10000 B. 50000 C. 100000 D. 25000

28. What is the most common mechanism of vascular leakage in acute inflammation ?

A. Contraction of endothelial cell B. ApoptosisC. Direct endothelial cell injury D. Necrosis

29. Increased incidence of cancer in old age is due to

A. Telomerase reactivation B. Telomerase deactivationC. Increased apoptosis’ D. Inactivation of protooncogene

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RC-A6

30. Which is most abundant glycoprotein present in the basement membrane?

A. Fibronectin B.  LamininC.  Collagen type 4 D. Heparin sulphate

Which of the following anti-cancer drug, which is known to cause the side effect of haemorrhagiccystitis ?

31.

A. Methotrexate, ALL B.  Cyclophosphamide, Breast cancerC.  Rituximab, NHL D. Dacarbazine, malignant melanoma

A pregnant mother had history of recurrent abortions for which she was put on anti-coagulants upuntil the time of delivery. She underwent a LSCS due to slow progression of labour. On birth, thechild seemed to have small limbs and nose in comparison to the trunk.On X-ray, it seemed as if thechild has some holes in the epiphyseal region of the humerus. The drug which may have caused thisis ?

32.

A. Enoxaparin B.  Fondaparinaux C.  Warfarin D. Apixaban 

33. What is the mechanism of action of vigabatrin ?

A. Inhibits release of GABA B.  Inhibits synthesis of GABAC.  Inhibits reuptake of GABA D. Inhibits degradation of GABA

34. Which of the following drugs causes induction of microsomal enzymes ?

A. Cisapride B.  Phenytoin C.  Cyclosporine D. Benzodiazepine

35. Low apparent volume of distribution means that

A. The drug is rapidly eliminated by the kidneysB.  The drug has a low half lifeC.  The drug has a low plasma protein binding capabilityD. The drug is not extensively distributed into tissues

36. What is hallmark of congenital hypertrophic pyloric stenosis ?

A. Hypokalemic hypochloremic metabolic alkalosisB. Hypokalemic hyperchloremic metabolic acidosisC. Hyperkalemic hyperchloremic metabolic alkalosisD. Hyperkalemic hyperchloremic metabolic acidosis

37. As an immediate response to surgical stress, all hormones are increased except ?

A. Cortisol B. Growth hormone C. Insulin D. ACTH

38. What is normal intra-abdominal  pressure ?

A. 5-7 mmHg B. 8-12 mmHg C. 10-20 mmHg D. 1-5 mmHg

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RC-A7

39. What is first line treatment of septic shock ?

A. Blood products B. Crystallloids C. Vasopressors D. Inotropes

40. What is the initiating event in the development of appendicitis ?

A. Luminal obstruction B. Bacterial invasionC. Ischemia D. Constipation

41. Which is the most common malignant tumor of parotid ?

A. Pleomorphic adenoma B. Muco-epidermoid carcinomaC. Warthin's tumor D. Adenocystic carcinoma

42. Which of the following structure does not form boundaries of Calot triangle ?

A. Cystic duct B. Inferior border of liverC. Right hepatic duct D. Common hepatic duct

43. Haemorrhage after thyroidectomy is most commonly due to injury of ?

A. External carotid artery B.  Internal carotid arteryC.  Superior thyroid artery D. Inferior thyroid artery

44. What is classical triad of Budd-Chiari Syndrome?

A. Fever, jaundice, abdominal pain B.  Fever ascites, jaundiceC.  Hepatomegaly, abdominal pain, ascites D. Abdominal pain, jaundice, hepatomegaly

45. What is most common cause of peritonitis in adult male?

A. Abdominal tuberculosis B.  Duodenal ulcer perforationC.  Enteric perforation D. Perforated appendix

A known case of Tubotympanic disease was taken up for surgery and on examining the middle ear,few chalky white deposits were found between the ossicles. What is the diagnosis?

46.

A. Otosclerosis  B. Tympanosclerosis C. Myringosclerosis  D. Candidal infection of the middle ear

A 60-year-old diabetic presented with severe pain in ear and otorrhoea not responding toantibiotics. On examination, granulation tissue is seen in EAC, facial nerve palsy was present. Thelikely diagnosis is:

47.

A. Otomycosis  B. Serous otitis media C. Malignant otitis externa  D. Eczematous otitis externa

Polypoidal mass in middle ear which bleeds heavily on touch in a patient with history of hearingloss and tinnitus is due to:

48.

A. Angiofibroma B. Exostosis C. Glomus jugulare  D. Acoustic neuroma

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RC-A8

49. The following type of upsloping audiogram is seen in

A. Ototoxicity B. Presbycusis C. Noise induced hearing loss D. Early Stage of Meniere’s disease

Patient developed a severe cough while performing the cold calorie test on him. Which of thefollowing nerve can be attributed to this?

50.

A. Auriculotemporal nerve  B. Auricular branch of vagus nerve C. Greater auricular nerve  D. Facial nerve 

51. Which among the following is called as transient hypopyon syndrome?

A. Behcet's disease  B. Reiter's syndrome C. Heerfordt's syndrome D. Still's disease

A child has congenital cataract involving the visual axis, which was detected at birth. When shouldthe child be operated up on?

52.

A. At 4-6 weeks of age B. At 5 months of age C. At 1 year of age, when the globe attains normal size D. At 4 years, when ocular and orbital growth is complete 

53. Late-onset endophthalmitis after cataract surgery is caused by which bacteria?

A. Staphylococcus epidermidis  B. Pseudomonas C. Streptococcus pyogenes  D. Propionibacterium acne

54. "Cattle-trucking" on fundoscopy is seen in which condition?

A. Central retinal venous occlusion (CRVO) B. Central retinal artery occlusion (CRAO)C. Diabetes mellitus  D. Syphilis 

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RC-A9

Use of highly active anti-retroviral therapy is associated with the development of which condition?55.

A. Keratitis B.  Anterior uveitisC.  Posterior uveitis D. Optic neuritis

56. For which of the following Agnes Hunt traction is used?

A. Flexion deformity of hip B.  Trochanteric tractionC.  Fracture shaft of femur D. Supracondylar fracture of humerus.

A 22-year old young male, college student, suffered a left knee injury while playing hockey. After2 months, there was anterior laxity in full extension and it was normal at 90° flexion. What is themost likely injured part ?

57.

A. Anteromedial bundle of anterior cruciate ligamentB.  Posterolateral bundle of anterior cruciate ligamentC.  Posterior cruciate ligamentD. Anterior part of medial meniscus.

58. All of the following can be the result of carpal tunnel syndrome except ?

A. Paralysis of opponens pollicisB.  Paralysis of flexor pollicis brevisC.  Paralysis of oblique head of adductor pollicisD. Paralysis of abductor pollicis brevis.

Which of the following is genetically determined disorder in the structure or processing of type Icollagen ?

59.

A. Osteogenesis imperfecta B.  Osteitis deformansC.  Osteitis fibrosa cystica D. Osteomalacia.

60. Which of the following is the ideal site for harvesting bone graft?

A. Iliac crest B.  Distal end of humerousC.  Distal end of femur D. Fibula

Which of the following tumour antigen is correctly paired with its ovarian tumour or malignancy ?61.

A. AFP- DysgerminomaB.  HCG- Granulosa cell tumourC.  CA19- 9 mucinous epithelial ovarian cancerD. LDH- embryonal cell cancer

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RC-A10

Which of the following is the most likely ovarian cancer to develop in women with endometriosis62.

A. Endometroid carcinoma B.  Clear cell carcinomaC.  Granulosa cell carcinoma D. Serous cystadenocarcinoma.

A 20 year old woman with primary amenorrhea with short stature and shield shaped chest andabsent breast development. What is the most likely cause of her amenorrhea

63.

A. Eugonadotropic hypogonadism B.  Hypogonadotropic hypogonadismC.  Hypergonadotropic hypogonadism D. d. Lower outflow tract obstruction

64. All of the following drugs are used for medical management of ectopic pregnancy except

A. Methotrexate B.  Potassium chlorideC.  Misoprostol D. Mifepristone

Creamy-white watery discharge with fishy odour from vagina is due to which of the followinginfection?

65.

A. Candida B.  GonorrheaC.  Trichomonas D. Bacterial vaginosis

66. Which of the following levels of prevention are not matched correctly ?

A. DOTS- Primary levelB.  Crutches in Polio - Tertiary LevelC.  Salt restriction in children - Primordial preventionD. Pap Smear - Secondary level of prevention

67. India is in which stage of the demographic cycle now ?

A. High Stationary  B.  Early expanding C.  Late expanding D. Low stationary

68. What is the main difference between Case control and Cohort studies ?

A.  Case control - Temporality present, Cohort - Temporality absentB.  Case Control - Retrospective study, Cohort - Prospective study C.  Case control - Attrition bias, Cohort - Recall biasD. Case Control - Relative risk, Cohort - Odds ratio

69. What is energy requirement of an infant, for whom artificial feeding is being planned?

A. 50kcal/kg body weight B.  100 kcal/kg body weightC.  70 kcal/kg body weight D. 130 kcal/kg body weight

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RC-A11

70. Match the following biomedical wastes and their BMW management colour coded disposal bags

A. 1-b,2-c,3-a,4-d B.  1-c,2-b,3-a,4-dC.  1-d,2-c,3-b,4-a D. 1-c,2-d,3-d,4-a

Incidence of gonorrhoea is continuously increasing in a particular locality. An investigator revealsthat mostly sex workers are living there. This epidemic may be classified as:

71.

A. Common source single exposure B.  Common source continuous exposureC.  Propagated epidemic D. Slow epidemic.

72. Vaccine carrier can maintain temperature of vaccine for how many hours?

A. 6-12 hrs B.  12-18 hrs C.  24-48 hrs D. 48-96 hrs

A 7 month old infant was vaccinated for measles due to measles outbreak in the community. Whatshould be done next when the child comes for routine immunization?

73.

A. Give a second dose after 6 weeks B.  Give a second dose at 9 month of ageC.  Give a second dose at 16 month of age D. No further dose is needed

74. Prevalence is a

A. Rate B.  Ratio C.  Proportion D. None

For sputum smear to come positive on ZN staining, what should be the minimum bacilli per ml ofsputum ?

75.

A. 10 B.  100 C.  1000 D. 10000

ICMR Delhi and NIV Pune have developed an ELISA kit for COVID-19 antibody detection test,known as ?

76.

A. Nishchay ELISA B.  Aarogya ELISA C.  Chhaya ELISA D. Kavach ELISA

77. During first week of infection dengue can be best detected in clinical practice by

A. NS 1 Antigen detection B.  MAC-ELISA for IgM antibodyC.  Viral RNA detection by RT-PCR D. Viral culture

a. Implants

b. Soiled bedsheets

c. Gloves

d. Scalpel

1. Yellow Bag 2. Red Bag

3. Blue Bag

4. White transparent container

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RC-A12

78. Indradhanush program is related to immunization of which group of population?

A. Children up to 1 year of ageB. Pregnant women and children up to 2 years of ageC. All children under 5 year of ageD. Girl child up to 15 year of age

79. At the end of 1 year of age, number of carpal bones seen in the skiagram of the hand is

A. Nil B. 1 C. 2 D. 3

80. Keshan disease is caused by severe deficiency of

A. Iodine B. Chromium C. Selenium D. Iron

A patient with complaints of loss of vision has been referred to you by the ophthalmologist. Onfurther enquiry and examination, he has jaundice, and also has difficulty in initiating movements,along with fine tremors. What is the screening test of choice for this disease ?

81.

A. Serum Free Cu2+ B. Urinary free Cu2+ C. Serum ceruloplasmin D. Liver Biopsy

A patient of age 71 years presented to you with the complaints of loss of speech and right sidedweakness for the last 1 hour. His BP is 170/100. He is a known hypertensive and smoker. There is ahistory of falling down from a chair. What is your next step ?

82.

A. CT BrainB. MRI brain - Diffusion weighted imagingC. Start IV thrombolysis using reteplaseD. First control BP using amlodipine then start anti platelet drugs.

A woman with a history of diabetes for 10 years with poor glycaemic control, has come to youfacial puffiness. She has purple striae on her abdomen and a central obesity. What is the most

83.

A. Pituitary adenoma B. Exogenous drug administrationC. Adrenal adenoma D. Paraneoplastic syndrome

Ms. P, diagnosed with systemic lupus erythematosus is undergoing baseline evaluations. What isthe most common cardiac manifestation in this condition?

84.

A. Pericarditis B. Myocarditis C. Libman Sack Endocarditis D. Myocardial infarction

A 40-year-old woman with a history of multiple sclerosis comes to the hospital. She describes anelectric shock-like sensation radiating down the back into the legs. What is the name of this sign?

85.

A. Uhthoff's phenomenon B. Lhermitte's sign C. Myokymia D. None of the above

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RC-A13

86. Which of the following drugs is used as an anti-smoking agent ?

A. Busulfan B.  Bupropion C.  Gabapentin  D. Acamprosate

A patient of anorexia nervosa was eating her meals according to the prescribed diet chart but thereis no change in her body weight after 1 week. What do you think is the most likely cause behindthis ?

87.

A. Improper adherence to diet chart B.  Post meal vomitingC.  Hyper metabolic state like fever D. Improper intake of SSRI

88. True Koebner’s Phenomenon is seen in :-

A. Molluscum B.  Lichen sclerosisC.  Eryhtema Multiforme D. Psoriasis

A 45-year-old woman presented with gradually worsening productive cough and shortness ofbreath. In recent months, she had frequent visits to the OPD for nasal congestion and earache. Onexamination, her BP is 160/100. Laboratory investigations reveal elevated ESR and positive forANCA. Urine examination shows proteinuria. What is  the most likely diagnosis?

89.

A. Good Pasture syndrome B. Granulomatosis with polyangiitis C. Microscopic polyangiitis  D. Churg-Strauss syndrome 

61-year-old man presents to the hospital with fever, dry cough, and difficulty breathing. He alsoreports feeling very tired and unwell. He has a history of hypertension, which is controlled withenalapril. Chest x-ray shows bilateral lung infiltrates, and computed tomography of the chestreveals multiple bilateral lobular and subsegmental areas of ground-glass opacity. Anasopharyngeal swab is sent for testing and results are awaited. The patient develops respiratorydistress 2 days after admission and is transferred to the intensive care unit and is to be started onmechanical ventilation. What is the recommended ventilator setting?

90.

A. Low tidal volume and high PEEP B. Low tidal volume and low PEEP C. High tidal volume and high PEEPD. High tidal volume and low PEEP

A boy of 3 years is a known case of Nephrotic syndrome, has come to you with recurrence ofswelling of face and abdomen and legs, accompanied with fever and pain abdomen. There is nohistory of vomiting or passage of loose stool. What is the most probable diagnosis ?

91.

A. Pancreatitis B.  Spontaneous Bacterial PeritonitisC.  Hepatitis D. Gastritis

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RC-A14

92. Which of the following is not a major criteria to diagnose Acute Rheumatic Fever ?

A. Erythema Nodosum B.  Sydenham’s ChoreaC.  Carditis D. Arthritis

93. What is the most important mechanism of phototherapy, to reduce bilirubin levels ?

A. Structural isomerization to Lumirubin B.  Conformational isomerizationC.  E-Z enantiomer conversion D. None of the above.

A child presented with the dyspnea, failure to thrive and swelling of both limbs at 6 weeks of life.On auscultation, you are unable to hear any heart sounds but can hear a loud, pan systolic murmur;you could also hear B/L crepts. On CXR, there is cardiomegaly and pulmonary plethora. What isyour diagnosis ?

94.

A. ASD B. VSDC. PDA D. Fallot’s Tetralogy

A child of Down’s syndrome presents with sudden onset of weakness of all limbs. On examination,there is hyporeflexia of all limbs. Which of the following characteristics of Down’s syndromecould have predisposed the child to developing this ? ( Mark the  one with the highest risk )

95.

A. Higher risk of developing Leukemia, therefore leading to vertebral metastasis and collapseB.  Atlanto-axial joint instabilityC.  Improper development of coordination between limbsD. Associated cerebral palsy 

96. The dye used for the diagnosis of esophageal perforation:

A. Gastrografin  B. Iohexol  C. Gadolinium  D. Barium sulphate

40 year old female was sent to radiology department for thyroid USG scan. Which probe will beused for thyroid scan?

97.

A. Phase array B.  Curvilinear C.  Endocavitory D. Linear

98. What is X Ray view, used for optic canal?

A. Water’s view B.  Towne’s view C.  Rhese’s view D. Caldwell view

Liver lesion showing multi septate cystic areas with eggshell or mural calcifications on CT scan, issuggestive of?

99.

A. Hemangioma B. Hydatid cystC. Amoebic liver abscess D. Hepatocellular carcinoma

100. Radiofrequency waves are used in which of the following investigations?

A. PET scan B.  MRI C.  CT Scan D. Ultrasound

RC-A

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