qualitative organic analysis – ch 351 nmr...
TRANSCRIPT
Qualitative Organic Analysis –CH 351
NMR Spectroscopy
Bela TorokDepartment of Chemistry
University of Massachusetts BostonBoston, MA
General Aspects
2
Theoretical base of NMR spectroscopy
General Aspects
3
General Aspects
Theoretical base of NMR spectroscopy
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General Aspects
Theoretical base of NMR spectroscopy
General Aspects
Schematic diagram of an NMR spectrometer
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General Aspects
Handling
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General Aspects
Magnetic field
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General Aspects
Pulsed NMR
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General Aspects
Relaxation
Spin-Lattice Relaxation (longitudinal or T1)
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General Aspects
Relaxation
Spin-Spin Relaxation (T2)
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General Aspects
Shielding
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General Aspects
NMR active nucleii (elements)
Odd number of protons and/or neutrons
(strongly depends on natural abundance)1H , 2H (3H)13C15N18O check!19F31P
and many others
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General Aspects – 1H NMR Spectroscopy
Equivalent vs. Nonequivalent nucleii
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General Aspects – 1H NMR Spectroscopy
Equivalent vs. Nonequivalent nucleii
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General Aspects – 1H NMR Spectroscopy
Equivalent vs. Nonequivalent nucleii
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General Aspects – 1H NMR Spectroscopy
Equivalent vs. Nonequivalent nucleii
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General Aspects – 1H NMR Spectroscopy
Equivalent vs. Nonequivalent nucleii
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General Aspects – 1H NMR Spectroscopy
Equivalent vs. Nonequivalent nucleii
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Chemical Shift
General Aspects – 1H NMR Spectroscopy
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General Aspects – 1H NMR Spectroscopy
Chemical Shiftδ = dist. down field from TMS (Hz) / op. frequency (MHz)
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – Mass Analyzers General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – 1H NMR SpectroscopyChemical Shift
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
Diamagnetic anisotropy
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General Aspects – 1H NMR Spectroscopy
Chemical Shift
Diamagnetic anisotropy
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General Aspects – 1H NMR Spectroscopy
Chemical Shift Diamagnetic anisotropy
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General Aspects – 1H NMR Spectroscopy
Chemical Shift Diamagnetic anisotropy
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General Aspects – 1H NMR Spectroscopy
Chemical Shift Diamagnetic anisotropy
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General Aspects – 1H NMR Spectroscopy
Integration
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General Aspects – 1H NMR Spectroscopy
Integration
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General Aspects – 1H NMR Spectroscopy
Integration
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General Aspects – 1H NMR Spectroscopy
Integration
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling splitting of the signals
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling splitting of the signals
N+1 rule
(2I+1 in general)
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling splitting of the signals
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling long range splitting
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Geminal Coupling Spin-Spin Coupling
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
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General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Coupling Constant
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Coupling Constant
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Coupling Constant
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Coupling Constant
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Splitting Diagram
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Splitting Diagram
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Splitting Diagram
General Aspects – 1H NMR Spectroscopy
Spin-Spin Coupling – Splitting Diagram
General Aspects – 1H NMR Spectroscopy
Enantiotopic hydrogens
General Aspects – 1H NMR Spectroscopy
Diastereotopic hydrogens
General Aspects – 1H NMR Spectroscopy
Diastereotopic hydrogens
General Aspects – 1H NMR Spectroscopy
Time dependence - slow method
General Aspects – 1H NMR Spectroscopy
Time dependence - slow method
General Aspects – 1H NMR Spectroscopy
Time dependence - slow method
Effect of the medium
General Aspects – 1H NMR Spectroscopy
General Aspects – 1H NMR Spectroscopy
Resolution of spectra