Public/Private Partnerships in Neuroscienceand

The George & Ann Ryan Neuroscience Institute

Interdisciplinary Neuroscience Program

Neuroscience

Understanding the mysteries of the brain and the nervous system—is a top priority

 From seeking cures for neurodegenerative and neurological diseases

and disorders

to addressing mental illness, drug addiction, and substance abuse and developing effective treatments for brain injuries…

 neuroscience has emerged as a compelling scientific & medical

frontier

Interdisciplinary Neuroscience Program

Neuroscience

• accounting, finance, management, marketing, and supply chain management

require the science of decision-making

• the study of business decision-making has slowly begun to mold itself to

the study of neuroscience (or, more specifically, neuroeconomics) • With mouse-click data in marketing and tick-by-tick transaction

data from the financial markets it is now practical and competitive to study the extent to which emotion contributes to the assessment of subjective value

Interdisciplinary Neuroscience Program

What is Alzheimer’s Disease?

• Most common form of dementia• 5 million are living with the disease

in the US (1 in 9 over 65)• 36 million globally• 95% are sporadic; late onset (LOAD)• 5% are genetic; early onset before

age 60 (EOAD)• 6th leading cause of death• No known cure

Modified from: http://southernbourbonmountains.blogspot.com 2013_11_01_archive.html

Interdisciplinary Neuroscience Program

Percentage Changes in Selected Causes of Death 2000 - 2010

Cause of Death

Alzheimer’s Disease

Stroke Prostate Cancer

Breast Cancer

Heart Disease

HIV

(Alzheimer’s Association, 2013 Alzheimers Dement)

500,000 may die each year, making AD the THIRD leading cause of death. Rush University Medical Center, March, 2014

Interdisciplinary Neuroscience Program

Projected number of people above 65 with AD

Interdisciplinary Neuroscience ProgramInterdisciplinary Neuroscience Program

VISION: Make Rhode Island the Leading State in

Neuroscience ResearchConnect URI, Lifespan, RIH and Brown to form an effective network that makes neuroscience the major focus of biomedical research in RI

Seek private and federal funding to establish a continuum of research from the bench to the bedside

Complement URI’s strength (drug discovery, engineering, and psychology) with Brown’s established neuroscience program and the clinical capability of RIH and Lifespan

Offer solutions for neurodegenerative diseases and CNS disorders

Interdisciplinary Neuroscience Program

The George & Ann Ryan Neuroscience Institute

The George & AnneRyan Institute forNeuroscience—

EstablishedNovember 14, 2013by Tom and Cathy

Ryan with theirgenerous gift of

$15 million dollars,the single largestcharitable gift inthe University ofRhode Island’s

Interdisciplinary Neuroscience Program

Physical Space (Institute)

Student Fellowships

Thematic Faculty Cluster Hires

Renowned Director

Funds: pilot studies, seed grants, startup, staff

Building Blocks

*Institute Staff (coordinator, clerical etc.)

Interviews in Progress

4 awarded

Interdisciplinary Neuroscience Program

Discovery

SynthesisExperimentation

Screening  

Preclinical

Animal testingIn vitroIn vivo

 Development

Clinical Trials 

Products

DrugsDevices

 

University of Rhode Island Brown University

Norman Price Neuroscience InstituteRIH-Lifespan

Neurodegenerative Diseases, other CNS Disorders

INPGARIN

COBREBIBS

Diagnosis Formulations Devices Assays Imaging Treatment Prevention

Basic and Cognitive NeuroscienceCell and Molecular Biology

NeurobiologyClinical studies

CISND

Diagnosis and Treatment of Neurological DisordersCell and Molecular Biology

PharmacologyToxicology

Engineering Automation

PsychologyNursing

Neurobiology

Figure 2. Neuroscience Research in RI.

Statewide Approach

Interdisciplinary Neuroscience Program

Rhode Island Neuroscience Collaborative (RINC)

An enterprise developed by the Interdisciplinary Neuroscience Program at URI, the Brown Institute for Brain Science and the Norman Prince Neurosciences Institute to encourage and support new inter-institutional research collaborations in the neurosciences In June 2014 five projects that showed promise were funded through RINC and other processes

Each project is led by one Co-Principal Investigator from URI and one Co-Principal Investigator from Brown/RIH

THANK YOU FOR LISTENING!