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TRANSCRIPT
Public Health Impact of Cannabis Legalization: What Do We Know so Far?
Presented at the 2019 Medical Cannabis Symposium: The intersection of clinical practice and science
Rutgers University and New Jersey Department of HealthDecember 2019
Beatriz H Carlini, PhD, MPH
It is a brave new world
It is a brave new world
Agenda for today
Cannabis Legalization
Product
Market
People
Other products
State Cannabis Programs
2016
2016
2016
2018
2018
2016
^
* VT and DC have legal medical marketplaces, but no legal adult use marketplaces^ The KS Governor passed a bill to exempt CBD oil from the definition of marijuana, effectively legalizing CBD, though no THC is allowed in the product
Source: Schauer, G. Overview of Cannabis Policies in U.S. States: Implications for Public Health. Presented at North American Cannabis Summit, Los Angeles, Jan 2019
*
*
Medicinal laws
• Compassion
• Patient-centered
• Qualifying conditions and regulations vary widely
New Jersey• Chronic pain musculoskeletal disorders (28.9%),
• Anxiety (23.8%)
• Intractable skeletal spasticity (15.3%)
• PTSD (7.9%)
• Pain due to cancer or HIV (5.6%)
• Recent inclusion of Opiate Use Disorders
Source: https://www.nj.gov/health/news/2019/approved/20190724b.shtml accessed 12.15.19
Non medical legalization
Prohibition = Mass incarceration
= Unsafe and potent product
Legalization = Criminal justice
= Safe, regulated products
= Revenues for public good
= Substitution
Time, manner and regulations vary: home grow, cap on retail stores and personal use, taxation, warning labels, advertising.
Fifty shades of weed
Cannabis Legalization
Product
Market
People
Other products
Marijuana flowers potency, WA.
Smart R, Caulkins JP, Kilmer B, Davenport S, Midgette G. Variation in cannabis potency and prices in a newly legal market:
evidence from 30 million cannabis sales in Washington state. Addiction. 2017 May 27. doi: 10.1111/add.13886. [Epub ahead of print]
20% THC
Industry perspective• 69% THC• Shelf stable• Imperfect buds
Consumer perspective• 69% THC• “Healthier”• No scent
Product diversification
Concentrates: diversification of production
Carlini B. Vaping Marijuana. Alcohol & Drug Abuse Institute, University of Washington, June 2016. URL: http://LearnAboutMarijuanaWA.org/factsheets/vaping.htm.
Water
• Kief
• Hash
Solvent
• Wax
• Shatter
• BHO
• RSO
CO2
• CO2 Oil
Naphtha, Ether, Butane Glycerol
Concentrates’ market share in WA.
22%
66%
+ 146%
- 22%
Smart R, Caulkins JP, Kilmer B, Davenport S, Midgette G. Variation in cannabis potency and prices in a newly legal market:
evidence from 30 million cannabis sales in Washington state. Addiction. 2017 May 27. doi: 10.1111/add.13886. [Epub ahead of print]
Product Innovation – delivery devices
Dabbing: traditional paraphernalia
https://www.leafly.com/news/cannabis-101/how-to-dab-cannabis-concentrates Retrieved 10.27.2016
1- MJ concentrate2- Water pipe3- Nail4- Dome5- Torch6- Dabber
E-Dabs
https://www.leafly.com/news/strains-products/the-best-dab-rig-for-any-situation. Retrieved 10.27.2016
Quality control and Testing
Contaminants/residues
• Pesticides
• Heavy Metals
• Mold and mildew
Pesticide residues in Washington State
present in 84.6% of 24 market samples,
including potentially neurotoxic and
carcinogenic agents
Quality control and Testing
✓ No universal standards for laboratory testing protocols
✓ Systematic differences in the cannabinoid content reported by different laboratories
THC content
https://www.leafly.com/news/industry/leafly-investigation-washingtons-top-cannabis-lab-inflating-thc-numbers, retrieved 7.23.19
Accreditation Program: 2024
Summary- products
Non-medical legalization:
- Has not decreased potency
- Has not assured a safer product
- And there is the vaping crisis!
Things may change!
- The industry is not mature, is not sanctioned at a federal level and is market-oriented
- Regulatory agencies don’t have federal guidance neither track record
Price and advertising
Cannabis Legalization
Product
Market
People
Other products
Nascent market: price, volume, demand
Advertising:mainstreaming
Normalization: Everybody is doing it!
Marijuana advertisement exposure is high
High school students nationwide (n=12,988)
Recent months:
• 52.8% internet
• 32.1 % TV
• 24.1% magazine and newspapers
• 19.7% from radio
• 19% storefronts
• 16.6% from billboards
Dai H. Exposure to Advertisements and Marijuana Use Among US Adolescents. Prev Chronic Dis 2017;14:170253. DOI: http://dx.doi.org/10.5888/pcd14.170253
Summary: Nascent Market
• Production is not based on demand
• Advertising – create a demand
• New consumers
• Intensify use among current consumers
Cannabis use and associated problems
Cannabis Legalization
Product
Market
People
Other products
Where do we find data?
Most recent and comprehensive
• Data source: NSDUH-
• Representatives of states: WA, CO, AK and OR
• 2008-2016
• 17,000 to 18,000 per age group
Dr. Silvia Martins et al – School of Public Health at Columbia University
Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting
of the Research Society on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.
https://researchmj.org/resources/RSMj%20Full%20Conference%20Program%202019.pdf
Past month marijuana use before and after legalization, by age
4.8
13.1
5.75.3
14
7.1
0
2
4
6
8
10
12
14
16
Age 12-17 Age 18-25 Age 26+
% o
f Pa
st M
on
th U
se
Before After
OR=1.28 (1.16,1.40)
Dr. Silvia Martins et al – School of Public Health at Columbia University
Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting of the Research Society
on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.
Daily marijuana use before and after legalization among among last month users
22.9
38.337.1
23.2
40.5
37.8
0
5
10
15
20
25
30
35
40
45
Age 12-17 Age 18-25 Age 26+
% w
ho
use
mar
ijuan
a d
aily
Before After
Dr. Silvia Martins et al – School of Public Health at Columbia University
Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting of the
Research Society on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.
Past year Cannabis Use Disorder among past year users
22.8
16.6
9.1
27.2
15.7
10.4
0
5
10
15
20
25
30
Age 12-17 Age 18-25 Aged 26+
% C
UD
am
on
g p
ast
year
use
rs
Before After
Dr. Silvia Martins et al – School of Public Health at Columbia University
Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting of the Research
Society on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.
OR= 1.27 (1.01,1.59) –analysis indicates confounder
Source: WA Poison Center 2018 Annual Data Report – Cannabishttps://www.wapc.org/data/data-reports/cannabis-data-report/
Increase is consistent with national trends
Panic, anxiety and Cannabis Hyperemesis Syndrome
Summary: people
• Adults (26+) are increasing cannabis use
• No evidence of increase among youth
• Modest increase in problems
• Things may change - too early
• We need better measures, more research
Tobacco, Alcohol and Opiates
Cannabis Legalization
Product
Market
People
Other products
Addition or substitution?
Can cannabis substitute for opioids?
Yes: Preliminary research
▪ Patients narratives▪ One longitudinal study(*)
•Among people willing to utilize cannabis• Self Report•Observational
• Sexton M et al. A Cross-Sectional Survey of Medical Cannabis Users: Patterns of Use and Perceived Efficacy. Cannabis and Cannabinoid Research.
2016;1(1):131-8
• Ilgen MA et al. Characteristics of adults seeking medical marijuana certification. Drug Alcohol Depend. 2013;132(3):654-9.
• Bruce D et al. Preferences for Medical Marijuana over Prescription Medications Among Persons Living with Chronic Conditions:
Alternative, Complementary, and Tapering Uses. Journal of alternative and complementary medicine. 2018 Feb;24(2):146-153.
• Corroon JM, Jr., Mischley LK, Sexton M. Cannabis as a substitute for prescription drugs - a cross-sectional study. Journal of pain research.
2017;10:989-98.
• Reiman A et al. Cannabis as a Substitute for Opioid-Based Pain Medication: Patient Self-Report. Cannabis and cannabinoid research. 2017;2(1):160-
6.
• Boehnke KF et al. Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients
With Chronic Pain. The journal of pain : official journal of the American Pain Society. 2016;17(6):739-44.
• Lucas P et al. Substituting cannabis for prescription drugs, alcohol and other substances among medical cannabis patients:
The impact of contextual factors. Drug Alcohol Rev. 2016;35(3):326-33.
• Lucas P, Walsh Z. Medical cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical
cannabis patients. The International journal on Drug Policy. 2017;42:30-5.
• Nugent SM et al. Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy.
Gen Hosp Psychiatry. 2018;50(Supplement C):104-10.
• (*) Vigil JM et al. Associations between medical cannabis and prescription opioid use in chronic pain patients: A preliminary cohort study. PLoS
One. 2017;12(11):e0187795.
Barriers to substitution
▪ Access to cannabis as a medication:
▪ FDA regulated: stable product, studied in RCTs
▪ Covered by insurance
▪ Recommended by an educated health care force
▪ Cannabis as a harm reduction alternative
▪ No date, combination instead of substitution among high risk populations
▪ US – market-oriented legalization
Summary – Cannabis and other drugs
• Substitution makes sense in theory
• Profit and markets are driving legalization
• Federal prohibition hinders research on substitution
• Health services policies hinders ability to substitute
Final considerations
• Cannabis legalization – promises, promises
• Legalization is in its infancy
• Many moving pieces
• Our voices matter
• We can shape the next decade
Thanks!
Beatriz H. Carlini, PhD, MPH
Senior Research Scientist
Alcohol and Drug Abuse Institute- ADAI
Affiliate Associate Professor and
Director, Tobacco Studies Program
School of Public Health, Health Services
University of Washington