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Public Health Impact of Cannabis Legalization: What Do We Know so Far? Presented at the 2019 Medical Cannabis Symposium: The intersection of clinical practice and science Rutgers University and New Jersey Department of Health December 2019 Beatriz H Carlini, PhD, MPH

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Page 1: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Public Health Impact of Cannabis Legalization: What Do We Know so Far?

Presented at the 2019 Medical Cannabis Symposium: The intersection of clinical practice and science

Rutgers University and New Jersey Department of HealthDecember 2019

Beatriz H Carlini, PhD, MPH

Page 2: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

It is a brave new world

Page 3: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

It is a brave new world

Page 4: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Agenda for today

Cannabis Legalization

Product

Market

People

Other products

Page 5: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

State Cannabis Programs

2016

2016

2016

2018

2018

2016

^

* VT and DC have legal medical marketplaces, but no legal adult use marketplaces^ The KS Governor passed a bill to exempt CBD oil from the definition of marijuana, effectively legalizing CBD, though no THC is allowed in the product

Source: Schauer, G. Overview of Cannabis Policies in U.S. States: Implications for Public Health. Presented at North American Cannabis Summit, Los Angeles, Jan 2019

*

*

Page 6: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Medicinal laws

• Compassion

• Patient-centered

• Qualifying conditions and regulations vary widely

New Jersey• Chronic pain musculoskeletal disorders (28.9%),

• Anxiety (23.8%)

• Intractable skeletal spasticity (15.3%)

• PTSD (7.9%)

• Pain due to cancer or HIV (5.6%)

• Recent inclusion of Opiate Use Disorders

Source: https://www.nj.gov/health/news/2019/approved/20190724b.shtml accessed 12.15.19

Page 7: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Non medical legalization

Prohibition = Mass incarceration

= Unsafe and potent product

Legalization = Criminal justice

= Safe, regulated products

= Revenues for public good

= Substitution

Time, manner and regulations vary: home grow, cap on retail stores and personal use, taxation, warning labels, advertising.

Page 8: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Fifty shades of weed

Cannabis Legalization

Product

Market

People

Other products

Page 9: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Marijuana flowers potency, WA.

Smart R, Caulkins JP, Kilmer B, Davenport S, Midgette G. Variation in cannabis potency and prices in a newly legal market:

evidence from 30 million cannabis sales in Washington state. Addiction. 2017 May 27. doi: 10.1111/add.13886. [Epub ahead of print]

Page 10: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

20% THC

Industry perspective• 69% THC• Shelf stable• Imperfect buds

Consumer perspective• 69% THC• “Healthier”• No scent

Product diversification

Page 11: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Concentrates: diversification of production

Carlini B. Vaping Marijuana. Alcohol & Drug Abuse Institute, University of Washington, June 2016. URL: http://LearnAboutMarijuanaWA.org/factsheets/vaping.htm.

Water

• Kief

• Hash

Solvent

• Wax

• Shatter

• BHO

• RSO

CO2

• CO2 Oil

Naphtha, Ether, Butane Glycerol

Page 12: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Concentrates’ market share in WA.

22%

66%

+ 146%

- 22%

Smart R, Caulkins JP, Kilmer B, Davenport S, Midgette G. Variation in cannabis potency and prices in a newly legal market:

evidence from 30 million cannabis sales in Washington state. Addiction. 2017 May 27. doi: 10.1111/add.13886. [Epub ahead of print]

Page 13: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Product Innovation – delivery devices

Page 14: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Dabbing: traditional paraphernalia

https://www.leafly.com/news/cannabis-101/how-to-dab-cannabis-concentrates Retrieved 10.27.2016

1- MJ concentrate2- Water pipe3- Nail4- Dome5- Torch6- Dabber

Page 15: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

E-Dabs

https://www.leafly.com/news/strains-products/the-best-dab-rig-for-any-situation. Retrieved 10.27.2016

Page 16: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Quality control and Testing

Contaminants/residues

• Pesticides

• Heavy Metals

• Mold and mildew

Pesticide residues in Washington State

present in 84.6% of 24 market samples,

including potentially neurotoxic and

carcinogenic agents

Page 17: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Quality control and Testing

✓ No universal standards for laboratory testing protocols

✓ Systematic differences in the cannabinoid content reported by different laboratories

Page 18: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

THC content

https://www.leafly.com/news/industry/leafly-investigation-washingtons-top-cannabis-lab-inflating-thc-numbers, retrieved 7.23.19

Page 19: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Accreditation Program: 2024

Page 20: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Summary- products

Non-medical legalization:

- Has not decreased potency

- Has not assured a safer product

- And there is the vaping crisis!

Things may change!

- The industry is not mature, is not sanctioned at a federal level and is market-oriented

- Regulatory agencies don’t have federal guidance neither track record

Page 21: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Price and advertising

Cannabis Legalization

Product

Market

People

Other products

Page 22: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Nascent market: price, volume, demand

Page 23: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Advertising:mainstreaming

Page 24: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Normalization: Everybody is doing it!

Page 25: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Marijuana advertisement exposure is high

High school students nationwide (n=12,988)

Recent months:

• 52.8% internet

• 32.1 % TV

• 24.1% magazine and newspapers

• 19.7% from radio

• 19% storefronts

• 16.6% from billboards

Dai H. Exposure to Advertisements and Marijuana Use Among US Adolescents. Prev Chronic Dis 2017;14:170253. DOI: http://dx.doi.org/10.5888/pcd14.170253

Page 26: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Summary: Nascent Market

• Production is not based on demand

• Advertising – create a demand

• New consumers

• Intensify use among current consumers

Page 27: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Cannabis use and associated problems

Cannabis Legalization

Product

Market

People

Other products

Page 28: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Where do we find data?

Most recent and comprehensive

• Data source: NSDUH-

• Representatives of states: WA, CO, AK and OR

• 2008-2016

• 17,000 to 18,000 per age group

Dr. Silvia Martins et al – School of Public Health at Columbia University

Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting

of the Research Society on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.

https://researchmj.org/resources/RSMj%20Full%20Conference%20Program%202019.pdf

Page 29: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Past month marijuana use before and after legalization, by age

4.8

13.1

5.75.3

14

7.1

0

2

4

6

8

10

12

14

16

Age 12-17 Age 18-25 Age 26+

% o

f Pa

st M

on

th U

se

Before After

OR=1.28 (1.16,1.40)

Dr. Silvia Martins et al – School of Public Health at Columbia University

Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting of the Research Society

on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.

Page 30: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Daily marijuana use before and after legalization among among last month users

22.9

38.337.1

23.2

40.5

37.8

0

5

10

15

20

25

30

35

40

45

Age 12-17 Age 18-25 Age 26+

% w

ho

use

mar

ijuan

a d

aily

Before After

Dr. Silvia Martins et al – School of Public Health at Columbia University

Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting of the

Research Society on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.

Page 31: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Past year Cannabis Use Disorder among past year users

22.8

16.6

9.1

27.2

15.7

10.4

0

5

10

15

20

25

30

Age 12-17 Age 18-25 Aged 26+

% C

UD

am

on

g p

ast

year

use

rs

Before After

Dr. Silvia Martins et al – School of Public Health at Columbia University

Medical and Recreational Marijuana Laws in Adolescents and Young Adults: Where Do We Go from Here?. 3rd Annual Scientific Meeting of the Research

Society on Marijuana (RSMj), July 26-28, 2019, Vancouver, WA.

OR= 1.27 (1.01,1.59) –analysis indicates confounder

Page 32: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Source: WA Poison Center 2018 Annual Data Report – Cannabishttps://www.wapc.org/data/data-reports/cannabis-data-report/

Increase is consistent with national trends

Panic, anxiety and Cannabis Hyperemesis Syndrome

Page 33: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Summary: people

• Adults (26+) are increasing cannabis use

• No evidence of increase among youth

• Modest increase in problems

• Things may change - too early

• We need better measures, more research

Page 34: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Tobacco, Alcohol and Opiates

Cannabis Legalization

Product

Market

People

Other products

Page 35: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Addition or substitution?

Page 36: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Can cannabis substitute for opioids?

Yes: Preliminary research

▪ Patients narratives▪ One longitudinal study(*)

•Among people willing to utilize cannabis• Self Report•Observational

• Sexton M et al. A Cross-Sectional Survey of Medical Cannabis Users: Patterns of Use and Perceived Efficacy. Cannabis and Cannabinoid Research.

2016;1(1):131-8

• Ilgen MA et al. Characteristics of adults seeking medical marijuana certification. Drug Alcohol Depend. 2013;132(3):654-9.

• Bruce D et al. Preferences for Medical Marijuana over Prescription Medications Among Persons Living with Chronic Conditions:

Alternative, Complementary, and Tapering Uses. Journal of alternative and complementary medicine. 2018 Feb;24(2):146-153.

• Corroon JM, Jr., Mischley LK, Sexton M. Cannabis as a substitute for prescription drugs - a cross-sectional study. Journal of pain research.

2017;10:989-98.

• Reiman A et al. Cannabis as a Substitute for Opioid-Based Pain Medication: Patient Self-Report. Cannabis and cannabinoid research. 2017;2(1):160-

6.

• Boehnke KF et al. Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients

With Chronic Pain. The journal of pain : official journal of the American Pain Society. 2016;17(6):739-44.

• Lucas P et al. Substituting cannabis for prescription drugs, alcohol and other substances among medical cannabis patients:

The impact of contextual factors. Drug Alcohol Rev. 2016;35(3):326-33.

• Lucas P, Walsh Z. Medical cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical

cannabis patients. The International journal on Drug Policy. 2017;42:30-5.

• Nugent SM et al. Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy.

Gen Hosp Psychiatry. 2018;50(Supplement C):104-10.

• (*) Vigil JM et al. Associations between medical cannabis and prescription opioid use in chronic pain patients: A preliminary cohort study. PLoS

One. 2017;12(11):e0187795.

Page 37: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Barriers to substitution

▪ Access to cannabis as a medication:

▪ FDA regulated: stable product, studied in RCTs

▪ Covered by insurance

▪ Recommended by an educated health care force

▪ Cannabis as a harm reduction alternative

▪ No date, combination instead of substitution among high risk populations

▪ US – market-oriented legalization

Page 38: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Summary – Cannabis and other drugs

• Substitution makes sense in theory

• Profit and markets are driving legalization

• Federal prohibition hinders research on substitution

• Health services policies hinders ability to substitute

Page 39: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Final considerations

• Cannabis legalization – promises, promises

• Legalization is in its infancy

• Many moving pieces

• Our voices matter

• We can shape the next decade

Page 40: Public Health Impact of Cannabis ... - cpe.rutgers.edu FINAL Carlini 12.15.19.pdf · State Cannabis Programs 2016 2016 2016 2018 2018 2016 ^ * VT and DC have legal medical marketplaces,

Thanks!

[email protected]

Beatriz H. Carlini, PhD, MPH

Senior Research Scientist

Alcohol and Drug Abuse Institute- ADAI

Affiliate Associate Professor and

Director, Tobacco Studies Program

School of Public Health, Health Services

University of Washington