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PRPP synthetase. Nucleoside phosphorylases. Phosphoribosyl transferases. The committed step of de novo purine nucleotide biosynthesis. Phosphoribosylamine synthase: cooperativity with respect to PRPP concentration & product inhibition. Outline of de novo purine nucleotide biosynthesis. - PowerPoint PPT Presentation

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PRPPsynthetase

Nucleosidephosphorylases

Phosphoribosyltransferases

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The committed step of de novo purine nucleotide biosynthesis

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Phosphoribosylamine synthase: cooperativity with respect to PRPP concentration & product inhibition

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Outline of de novo purinenucleotide biosynthesis

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Outline of de novo pyrimidine nucleotide biosynthesis

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EnzymesI. Ribonucleotide reductaseII. Nucleotide diphosphate kinaseIII. dCMP kinaseIV. dUTP diphosphohydrolaseV. dCMP deaminaseVI. Thymidylate synthaseVII. FH2 reductase

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