protein physics lecture 7
DESCRIPTION
PROTEIN PHYSICS LECTURE 7. Main secondary structures. H-bonds. Helices: Right and Left. Mirror-asymmetric amino acids – mirror-asymmetric (“chiral”) helices Right -helix. Right -helix. Right -helix Right 3 10 helix. ALA, etc. GLY only. , twisted. , - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/1.jpg)
PROTEIN PHYSICSPROTEIN PHYSICS
LECTURE 7LECTURE 7
![Page 2: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/2.jpg)
Main secondary structuresMain secondary structures
![Page 3: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/3.jpg)
Helices: Helices: Right and LeftRight and Left
H-bondsH-bonds
![Page 4: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/4.jpg)
Mirror-asymmetric amino acids – Mirror-asymmetric amino acids – mirror-asymmetric (“chiral”) helicesmirror-asymmetric (“chiral”) helices
Right Right -helix-helix
![Page 5: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/5.jpg)
RightRight-helix-helix
![Page 6: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/6.jpg)
Right Right -helix-helix
Right 3Right 310 10 helixhelix
![Page 7: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/7.jpg)
![Page 8: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/8.jpg)
ALA, etc. GLY onlyALA, etc. GLY only
![Page 9: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/9.jpg)
![Page 10: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/10.jpg)
,,twistedtwisted
![Page 11: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/11.jpg)
,,twistedtwisted
![Page 12: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/12.jpg)
Mirror-asymmetric Mirror-asymmetric amino acids – amino acids –
mirror-asymmetric mirror-asymmetric twist of twist of -sheets-sheets
![Page 13: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/13.jpg)
-hairpin with turn-hairpin with turn
![Page 14: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/14.jpg)
turn Iturn I
turn I’turn I’
turn IIturn II
![Page 15: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/15.jpg)
-bulge-bulge
![Page 16: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/16.jpg)
collagen triple helixcollagen triple helix
![Page 17: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/17.jpg)
NMRNMRspectroscopyspectroscopy(cross-peaks)(cross-peaks)
ExperimentalExperimentalstudy of study of
secondary secondary structurestructure
X-ray X-ray crystallographycrystallography
![Page 18: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/18.jpg)
Far UV CD spectraFar UV CD spectra(peptide groups)(peptide groups)
IR spectraIR spectra(amid I, C=O bond)(amid I, C=O bond)
Experimental study of secondary structureExperimental study of secondary structure
![Page 19: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/19.jpg)
![Page 20: PROTEIN PHYSICS LECTURE 7](https://reader035.vdocuments.us/reader035/viewer/2022062218/56815ddf550346895dcc065a/html5/thumbnails/20.jpg)
GlobularGlobular
FibrousFibrous
H-bondsH-bonds & & hydrophobicshydrophobics
MembraneMembrane