protein kinase networks that limit tlr signalling by kristopher clark biochm. soc. trans. volume...

Protein kinase networks that limit TLR signalling

by Kristopher Clark

Biochm. Soc. Trans.Volume 42(1):11-24

February 1, 2014

©2014 by Portland Press Ltd

TLR signalling pathways leading to the production of pro-inflammatory cytokines(A) MyD88-dependent signalling pathway.

Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24


Negative regulation of TLR-mediated inflammation by MAPKsThe MAP3K TAK1 is at the head of the MAPK signalling cascade in response to TLR ligands (see Figure 1).



Regulation of TLR4 signalling by the PI3K pathway(A) Engagement of the TLR4 receptor at the cell surface recruits the adaptor TIRAP, and this interaction is stabilized by the association of

TIRAP with PIP2 present on the inner leaf of the plasma membrane.



Cross-talk within the IKK family(A) Activation of the IKKs. Recruitment of the TAK1 and canonical IKK complexes to polyubiquitin chains leads to the phosphorylation and activation of

IKKα and IKKβ by TAK1.



Control of anti-inflammatory cytokine production by the SIK/CRTC3 signalling cascadeTLR signalling leads to the phosphorylation of CREB at Ser133 driving the production of low levels of

the anti-inflammatory cytokine IL-10.



Early Career Research Award Delivered at the University of York on 17 July 2013 at the Signalling 2013: from Structure to Function Focused MeetingKristopher Clark.



protein kinase networks that limit tlr signalling by kristopher clark biochm. soc. trans. volume...

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