66 BioProcess International Industry yearbook 2017–2018 ADVERTORIAL

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S ince 1987, Prometic Bioseparations Ltd. (PBL) has been pioneering the design, development, and manufacture of affinity purification technology for laboratory-scale and industrial-scale bioprocessing.

With 30 years’ experience in the development of affinity products and design and manufacture of new custom adsorbents, PBL is a world leader in its field.

PBL offers an extensive range of off-the-shelf bioseparation products for the recovery and purification of biologicals and the removal of problem contaminants. We also offer a range of semidisposable bioprocess columns (Evolve™ columns) as well as a variety of custom development solutions.

Core Capabilities• Extensive range of bioseparation products• Custom designed chromatography adsorbents• 30 years’ experience and success• Cost-effective solutions• Proven Mimetic Ligand™ technology• Dedicated professional service• Full technical support and in-house training• Experts in adsorbent development and manufacture• Experts in downstream process development• Established ISO 9001 manufacturing facility• Semidisposable and prepacked disposable bioprocess

columns

• Large-scale manufacture with batch sizes up to 1,000 L and an annual capacity of over 37,000 L

• Current good manufacturing practice (CGMP) standard production in controlled environment areas

• More than 18 adsorbent products used in the manufacture of pharmaceuticals and medical products.

Prometic Bioseparations

Figure 1: Timeline

ACL become a whollyowned subsidiary of

ProMetic Life Sciences and changes name to ProMetic Biosciences

Limited (PBL)

ACL launches Mimetic Ligand™ a�nityproducts and establishes its �rst

manufacturing plant on the Isle of Man

ACL awarded QueensAward for Technological

Achievement

A�nity ChromatograpyLtd. (ACL) formed, spin

out company from University of Cambridge

Launch of PrioClear™ prionreduction technology

Launch of PuraBead™ base matrix

A�nity adsorbents forplasma puri�cation

(PPS™)

Launched Evolve™ Columns asinnovative semidisposable

hardware for columnchromatography market

New ligand screeningtoolkit launched

Scale of Isle of Manplant manufacturing

capacity increased from 9,000 to >35,000 liters

per annum

Corporate rebrandingand change of name to

Prometic Bioseparations Ltd.

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2015

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BioProcess International 67ADVERTORIAL Industry yearbook 2017–2018

PBL has an established manufacturing facility situated on the Isle of Man (British Isles) and can supply bulk adsorbent gel slurry for both developmental and regulated CGMP manufacturing applications in volumes sufficient to meet the requirements of the largest biomanufacturing processes.

All our bioseparation products are supported by comprehensive regulatory support files and are produced in our controlled-environment manufacturing facility under an ISO 9001 quality management system.

PBL has developed an extensive range of high-performance off-the-shelf bioseparation products for the recovery and purification of biologicals or contaminant removal.

The product range covers a diverse array of applications from protein purification (recombinant proteins, plasma proteins, antibodies, albumin and albumin fusion proteins, and glycoproteins) to contaminant removal (endotoxin, prions, and serine proteases), as shown in Table 1.

We also offer a range of custom services for downstream purification to either identify/optimize a suitable existing PBL product, custom design a bespoke chromatography adsorbent specifically for your target biomolecule and application, or develop and manufacture an adsorbent to your own specification.

If you cannot find a suitable off-the-shelf PBL product, then we can custom design a chromatography adsorbent specific to your target biomolecule. PBL experts in chromatography development and can help optimize all associated process parameters, including column packing, to maximize the yield and purity of your valuable protein.

To support the identification of custom affinity adsorbents, PBL also has developed a Multi-Mode Mimetic Ligand™ library in a 96-micro column block format (PuraPlate™) that can be screened in chromatographic (flow-through) mode. The library comprises a diverse array of stable synthetic ligands attached to a high-flow agarose support.

The ligands incorporate combinations of functional binding groups, including anionic and cationic groups, polar groups, apolar groups, and other specific chemical functionalities, all of which have been preselected based on their proven ability to interact with proteins.

To find out more visit our website: www.prometic.com/bioseparations. •

Andy Davies is sales and marketing director, Horizon Park, Barton Road, Comberton, Cambridge, CB23 7AJ, UK; 44-7831848644; a.davies@prometic.com

Table 1: Prometic bioseparation products

Bioseparation Product Range

Albumin and Albumin-Fusion Proteins

Antibody and Antibody Fragments

General Purification

Glycoprotein Separation

BiocontaminantRemoval

Insulin and Insulin Analogues

Mimetic Blue® 1 P6XL and SA HL P6XL

X

AlbuPure® XMAbsorbent® A1P,

A2P HF LL, and A2P HF

X

Fabsorbent™ F1P HF XIsoClear A™ and

IsoClear B™ (Isoagglutinins)

X

Octyl and Phenyl PuraBead® HF

X

DEAE, CM, Q and SP PuraBead® HF

X

Aminophenyl-boronate A6XL and

P6XL

X

EtoxiClear™ (endotoxin)

X

PrioClear™ adsorbents (prions)

X

p-Aminobenza-midine A6XL (serine

proteases)

X

Insulin adsorbent X