progress in stem cell biology and medical...

PRELIMINARY PROGRAM

STRESA, ITALY MAY 14 - 16, 2009

Your Continuing Medical Education Partnerwww.seronosymposia.org

Progress in stem cellbiology and medical

applications

FONDAZIONEOSPEDALE MAGGIORE POLICLINICO

MANGIAGALLI E REGINA ELENA

Università degli Studi di MilanoCentro di Ricerca sulle Cellule Staminali

AIM OF THE CONFERENCE

Stem cell research is currently one of the most active fields in biology aswell as one of the most controversial. It attracts attention from thescientific community and from the general public, often sendingcontradictory messages: great hopes for a rapid development of innovativetherapies or great fears of overstepping natural boundaries that shouldn’tbe reached.The research area related to all the different aspects of stem cell researchis vast and impossible to cover to any significant extent within the formatof a Conference. Therefore we decided to operate a selection based uponour collective experience and scientific interests in order to bring togetherscientists with different backgrounds and experimental approachesstimulating interdisciplinary contacts in a relaxed environment.The Conference will deal with the basic concepts of stemness and cellularreprogramming which will be illustrated side by side with the relatedaspects of reproductive biology. Assisted reproduction will be seen both assource of different types of stem cells as well as target for innovativetherapies. Tissue specific stem cells are sometimes seen as an alternativeto pluripotent stem cells and the Conference will illustrate progress in twovery active field: muscular/cardiac tissue and the central nervous system.

LEARNING OBJECTIVES

At the conclusion of this Conference, the participants will have an updatedknowledge on:• The principles and mechanisms which define a stem cell;• The concept that phenotype is no longer an immutable feature of

somatic cells;• The close relationship between reproductive biology, stem cells and

infertility treatments;• The biology of stem cells within muscular and cardiac tissues and their

therapeutic applications;• The rapidly evolving knowledge on stem cells within the nervous

system and the promise of curing neurodegenerative diseases.

Serono Symposia International FoundationConference on:

Progress in stem cell biology and medicalapplications Stresa, Italy - May 14 - 16, 2009

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All Serono Symposia International Foundation programs are organized solely to promote the exchangeand dissemination of scientific and medical information. No forms of promotional activities arepermitted. There may be presentations discussing investigational uses of various products. These viewsare the responsibility of the named speakers, and do not represent an endorsement or recommendationon the part of Serono Symposia International Foundation. This program is supported by an unrestrictededucational grant from Serono Symposia International Foundation.

TARGET AUDIENCE

Basic scientists, embryologists, neurologists, obstetricians, gynecologists,cardiologists, health institution managers and post graduate studentsinvolved in stem cell biology, reproductive biology, neurology and muscularphysiopathology.

ACCREDITATION

Serono Symposia International Foundation (www.seronosymposia.org)will submit this program “Progress in stem cell biology and medicalapplications” (Stresa, Italy - May 14 - 16, 2009) for accreditation by theEuropean Accreditation Council for Continuing Medical Education(EACCME).

Serono Symposia International Foundation will apply to the Royal Collegeof Physicians, London (UK), for CME accreditation of the Conference“Progress in stem cell biology and medical applications” (Stresa,Italy - May 14 - 16, 2009).

Serono Symposia International Foundation will submit this program“Progress in stem cell biology and medical applications” (Stresa,Italy - May 14 - 16, 2009) for CME accreditation by the Italian Ministry ofHealth.

SCIENTIFIC ORGANIZER

Fulvio GandolfiLaboratory of Biomedical EmbryologyCenter for Stem Cell ResearchUniversity of MilanMilan, Italy

CHAIRMAN

Guido RagniInfertility UnitFondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina ElenaMilan, Italy

SCIENTIFIC SECRETARIATSerono Symposia International FoundationSalita di San Nicola da Tolentino, 1/b - 00187 Rome, ItalyProject Manager: Francesca PellegrinoPhone: +39-06-420413 511- Fax: +39-06-420413 677E-mail: [email protected] Symposia International Foundationis a Swiss Foundation with headquarters in14, rue du Rhône, 1204 Geneva, Switzerland

ORGANIZING SECRETARIATMeridiano Congress International Via Mentana, 2/B - 00185 Rome, ItalyPoint Person: Federica RussettiPhone: +39-06-88595 209 - Fax: +39-06-88595 234E-mail: [email protected]

List of Speakers and Chairmen

SCIENTIFIC COMMITTEE

Elena CattaneoDepartment of Pharmacological Sciences and UniStem-Centre for Stem Cell ResearchUniversity of MilanMilan, Italy

Giancarlo ComiInstitute of Experimental NeurologyUniversity Vita-Salute IRCCSSan Raffaele HospitalMilan, Italy

Giulio CossuDivision of Regenerative Medicine, DibitSan Raffaele HospitalMilan, Italy

Bruno PeaultStem Cell Research CenterChildren’s Hospital of PittsburghDepartment of Orthopaedic SurgeryUniversity of Pittsburgh School of Medicine Pittsburgh, USA


Paolo RebullaU.O. Centro di Medicina TrasfusionaleTerapia Cellulare e CriobiologiaFondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina ElenaMilan, Italy

Yvan TorrenteDepartment of Neurological SciencesUniversity of MilanMilan, Italy

Alan TrounsonCalifornia Institute for Regenerative Medicine (CIRM)San Francisco, USA

LIST OF SPEAKERS AND CHAIRMEN

Tiziano Barberi Laboratory of Stem Cells and Development Beckman Research InstituteDuarte, USA

Ferruccio BoninoScientific DirectorFondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina ElenaMilan, Italy

Tiziana BreviniLaboratory of Biomedical EmbryologyUniStem-Centre for Stem Cell ResearchUniversity of MilanMilan, Italy

Elena CattaneoDepartment of Pharmacological Sciences and UniStem-Centre for Stem Cell ResearchUniversity of MilanMilan, Italy

Ian ChambersMRC Centre Development in Stem Cell Biology Institute for Stem Cell ResearchSchool of Biological SciencesUniversity of EdinburghEdinburgh, UK

Giancarlo ComiInstitute of Experimental NeurologyUniversity Vita-Salute IRCCSSan Raffaele HospitalMilan, Italy

Giulio CossuDivision of Regenerative Medicine, DibitSan Raffaele HospitalMilan, Italy

Sandra DannerGroup Manager Cell DifferentiationFraunhofer Institute of Marine Biotechnology (EMB)Lübeck, Germany

Sheng DingDepartment of Chemistry The Scripps Research InstituteLa Jolla, USA

Martin EvansDirector of the School of Biosciences and Professor of Mammalian GeneticsCardiff School of BiosciencesCardiff, UK

Amanda G. FisherLymphocyte Development GroupMRC Clinical Sciences CentreImperial College School of MedicineHammersmith HospitalLondon, UK

G. Ian GallicanoDepartment of Biochemistry & Molecular & Cellular BiologyGeorgetown University Medical CenterWashington, USA

Fulvio GandolfiLaboratory of Biomedical EmbryologyCenter for Stem Cell ResearchUniversity of MilanMilan, Italy

Luca GianaroliReproductive Medicine UnitItalian Society for the Study of Reproductive MedicineBologna, Italy


Kaomei GuanDepartment of Cardiology and PneumologyGeorg-August-University of GöttingenGöttingen, Germany

Lorenza LazzariCell Factory Centro di Medicina Trasfusionale, Terapia Cellulare e CriobiologiaFondazione IRCCSOspedale Maggiore Policlinico Mangiagalli e Regina ElenaMilan, Italy

Gianvito MartinoNeuroimmunology Unit - Institute of Experimental Neurology (Inspe)San Raffaele Scientific Institute Milan, Italy

Alexander MeissnerDepartment of Stem Cell and Regenerative BiologyHarvard Stem Cell Institute Harvard UniversityCambridge, USA

Christine L. MummeryDepartment of Anatomy and EmbryologyLeiden University Medical CentreLeiden, The Netherlands

Karim NayerniaStem Cell BiologyInstitute of Human GeneticsUniversity of Newcastle upon TyneInternational Centre for LifeNewcastle upon Tyne, UK

Bruno PeaultStem Cell Research CenterChildren’s Hospital of PittsburghDepartment of Orthopaedic SurgeryUniversity of Pittsburgh School of Medicine Pittsburgh, USA



Paolo RebullaU.O. Centro di Medicina TrasfusionaleTerapia Cellulare e CriobiologiaFondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina ElenaMilan, Italy

Stefan SchlattCentre for Reproductive Medicine and AndrologyUniversity of MünsterMünster, Germany

Azim SuraniWellcome Trust Cancer Research UK Gurdon Institute Cambridge, UK

Yvan TorrenteDepartment of Neurological SciencesUniversity of MilanMilan, Italy

Alan TrounsonCalifornia Institute for Regenerative Medicine (CIRM)San Francisco, USA

THURSDAY - MAY 14, 2009

15.00 Registration

16.00 SSIF WelcomeGiancarlo Comi, Italy

16.10 Opening RemarksGuido Ragni, Italy

16.15 Opening Lecture “Embryonic and other stem cells: a perspective”Martin Evans, UK - Nobel laureate 2007Chairman: Fulvio Gandolfi, Italy

SESSION 1Stemness and pluripotency

Chairmen: Elena Cattaneo, Italy - Bruno Peault, USA

17.00 Transcription factor control of ES cell self-renewalIan Chambers, UK

17.40 Noisy stem cells: Dynamic equilibrium and heterogeneity inpluripotent stem cellsAzim Surani, UK

18.20 The Role of MicroRNAs in Stem Cell FunctionG. Ian Gallicano, USA

19.30 - 22.00 Cheese & Wine Get Together

Scientific Program

SESSION 2Stem cells from reproduction

Chairmen: Alan Trounson, USA - Ferruccio Bonino, Italy

08.30 Multipotent adult germline stem cellsKaomei Guan, Germany

09.10 Stem cells from parthenogenetic embryosTiziana Brevini, Italy

09.50 Progenitor cells with multi-lineage potential in human amnioticfluidLorenza Lazzari, Italy

10.30 Coffee Break

SESSION 3Cell reprogramming

Chairmen: Martin Evans, UK - Azim Surani, UK

11.00 Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem CellsAlexander Meissner, USA

11.40 A Combined Chemical and Genetic Approach for the Generationof Induced Pluripotent Stem Cells/ A chemical approach to stem-cell biology and regenerative medicineSheng Ding, USA

12.20 Heterokaryon-Based Reprogramming of somatic cellsAmanda G. Fisher, UK

13.00 Lunch

FRIDAY - MAY 15, 2009

SESSION 4Stem cells for the therapy of infertility

Chairman: Luca Gianaroli, Italy

14.30 Spermatogonial stem cells: questions, models and perspectivesStefan Schlatt, Germany

15.10 From stem cells to germ cells and backKarim Nayernia, UK

15.50 Derivation of oocytes from somatic stem cell linesSandra Danner, Germany

16.30 Coffee Breaks

SESSION 5Stem cells in vascular, muscular and cardiac tissues

Chairman: Yvan Torrente, Italy

17.00 An ubiquitous reserve of multi-lineage mesodermal progenitors inblood vessel wallBruno Peault, USA

17.40 New therapies for Duchenne muscular dystrophy: challenges,prospects and clinical trialsGiulio Cossu, Italy

18.20 Cardiomyocytes from human embryonic stem cells indevelopment and diseaseChristine L. Mummery, The Netherlands

20.30 Conference Dinner

SESSION 6Stem cells in the nervous system

Chairman: Giancarlo Comi, Italy

09.00 Reconstructing the Human Neural Crest in Vitro from EmbryonicStem CellsTiziano Barberi, USA

09.40 Neural stem cell linesElena Cattaneo, Italy

10.20 Therapeutic plasticity of neural stem cellsGianvito Martino, Italy

11.00 Coffee Break

11.30 Closing Lecture “Integration and translation: driving stem celltherapies toward the clinic”Alan Trounson, USAChairman: Giulio Cossu, Italy

12.15 Closing ceremony

12.30 End of the Conference

SATURDAY - MAY 16, 2009

Scientific Program

PERSONAL DATA TREATMENT - INFORMATIVE DOCUMENTIn compliance with the article 13 of Italian Legislative Decree n. 196, 30 June 2003,we inform you that your personal data will be processed, with or without the use ofelectronic or automated means, via suitable tools that will guarantee security andconfidentiality. Personal data from you supplied will be communicated toContinuing Medical Education Accreditation Authorities, to agencies that will takecare of the whole accreditation process and agencies that will take care of thelogistics of the event; should we not receive the below requested data, we will notbe able to process your registration to the event.At anytime you may exercise your rights as laid down in the art. 7 of ItalianLegislative Decree n. 196, 30 June 2003 of the Italian Law, by contacting the DataController Serono Symposia International Foundation (Salita di San Nicola daTolentino, 1/b - 00187 Rome - Italy) in the person of Data Processor, MichèlePiraux.

VENUEThe Conference will take place at the:

REGINA PALACE HOTEL ****Corso Umberto I, 29 - 28838 Stresa (Verbania)Phone: +39-0323-936936 Fax: +39-0323-936666E-mail: [email protected] site: www.regina-palace.it

LANGUAGE

The official language of this Conference will be English.

REGISTRATION FEE

The registration fee is AA 350,00.

This fee includes:• All sessions• Conference coffee breaks, luncheons • Conference dinner (May 15, 2009)• Congress material• Certificate of attendance

* If you require special assistance (wheelchair, auxiliary aids) or specialdietary requirements, please, contact us at [email protected]

HOTEL ACCOMMODATIONSee the enclosed Hotel Accommodation Form.

General Information

HOW TO REACH STRESA

� BY AIR 35 km from Malpensa 2000 airport.110 km from Linate airport.

� BY TRAIN FFSS Milano - Domodossola, Station of Stresa.

� BY CAR Highway A26 exit Carpugnino - Stresa

LOCATIONStresa is a small town on the shores of the Lago (Lake) Maggiore andsituated on the road and rail routes to the Simplon pass in the region ofPiedmont in Italy. Since the early 20th century, the main source of incomehas been the tourist trade. Like other locations on Lago Maggiore, itbenefits from spectacular views as well as areas of historical andarchitectural interest. The name of Stresa first appeared in documentsdated 998; it has been under the jurisdiction and therefore property ofBorromei and Visconti families until the 19th century, when, thanks to thepresence of famous personages like Rosmini, Manzoni and the Duchessof Genoa, that is Elizabeth of Sassonia, Stresa began to gain prestige.The construction of the Simplon railway, at the beginning of the 20th

century, gave Stresa international fame. From the promenade, sprinkledwith grand hotels, villas, parks and gardens, you can have a magnificentview of the three islands of Lago Maggiore, and of the Alps far away.

Registration Form

Last Name First Name Academic Title

Institution Department

Address

City State/Country Zip

Office Telephone Number(s) Mobile Telephone Number(s)

Fax Number E-mail

REGISTRATION FEE: € 350,00

Please, note that Auditorium room capacity is limited for this event. Preference will begiven to early registrations.

I require special assistance (wheelchair, auxiliary aids) or special dietary requirements

PAYMENT

Payment by enclosed International check

Payable to: “Meridiano Viaggi e Turismo srl”

Payment by Bank Transfer headed to: “Meridiano viaggi e turismo s.r.l" BANCA INTERMOBILIARE INVESTIMENTI E GESTIONI S.p.AFILIALE DI ROMA - VIA DONIZETTI, 14 - 00198 ROMAAccount number: 000000003808IT11 C030 4303 2000 0000 0003 808 - SWIFT: BIMTITTTXXX

Payment by Credit Card

Charge to the following Credit Card: MasterCard/EuroCard Visa

Card Number Exp. Date

Card Holder Name (PLEASE PRINT) Card Holder’s Signature Date

ONLY REGISTRATION FORMS ACCOMPANIED WITH PAYMENT CAN BE PROCESSED.

Mail to: Federica Russetti • Meridiano Congress InternationalVia Mentana, 2/B • 00185 Rome, Italy

Phone: +39-06-88595 209 • Fax: +39-06-88595 234E-mail: [email protected]

Payment can be made by check or Bank Transfer or MasterCard/Visa.All completed Registration Forms will be acknowledged by mail or fax.

Cancellations after February 27, 2009 will not be reimbursed.



Mail to

:

Meridiano Congress International

Att:

Federica R

ussetti

Via M

entan

a, 2/B

00185 Ro

me

Italy

Hotel Accommodation Form

Last Name First Name Academic Title

Institution Department

Address

City State/Country Zip

Office Telephone Number(s) Mobile Telephone Number(s)

Fax Number E-mail

For hotel reservation, please return the completed form with full prepayment of the requested nights.Hotel Reservation forms without prepayment cannot be processed.

DEADLINE FOR RESERVATIONS: February 27, 2009Cancellations after February 27, 2009 will not be reimbursed.Reservations after this date are not guaranteed and will be made on a space-available basis.

REGINA PALACE HOTEL ****

Single room: € 180,00 per night Double room: € 260,00 per night

Check in Check out (N° of nights: )

Rates include breakfast and city taxes.

PAYMENT

Payment by Bank Transfer headed to: “Meridiano viaggi e turismo s.r.l" BANCA INTERMOBILIARE INVESTIMENTI E GESTIONI S.p.AFILIALE DI ROMA - VIA DONIZETTI, 14 - 00198 ROMAAccount number: 000000003808IT11 C030 4303 2000 0000 0003 808 - SWIFT: BIMTITTTXXX

Payment by Credit Card (Handling fee 3.5%):

Charge to the following Credit Card: MasterCard/EuroCard Visa

Card Number Exp. Date

Card Holder Name (PLEASE PRINT) Card Holder’s Signature Date

Mail to: Federica Russetti • Meridiano Congress InternationalVia Mentana, 2/B • 00185 Rome, Italy

Phone: +39-06-88595 209 • Fax: +39-06-88595 234E-mail: [email protected]



Mail to

:

Meridiano Congress International

Att:

Federica R

ussetti

Via M

entan

a, 2/B

00185 Ro

me

Italy

Your Continuing Medical Education Partnerwww.seronosymposia.org

Copyright © Serono Symposia International Foundation, 2009. All rights reserved.

FONDAZIONEOSPEDALE MAGGIORE POLICLINICO

MANGIAGALLI E REGINA ELENA

Università degli Studi di MilanoCentro di Ricerca sulle Cellule Staminali

progress in stem cell biology and medical...

Documents