Progress Against

Leukemia

Progress Against Leukemia

1970–1979

Progress Against Leukemia

1970–19791974: FDA approves doxorubicin

Progress Against Leukemia

1970–19791975: Era of bone marrow transplantation begins – extending lives of many patients with leukemia and lymphoma

Progress Against Leukemia

1970–19791977: Chlorambucil induces remissions for chronic lymphocytic leukemia

Progress Against Leukemia

1980–1989

Progress Against Leukemia

1980–19891982: Daunorubicin proven superior to doxorubicin for AML

Progress Against Leukemia

1980–19891986: National bone marrow transplantation registry is established

Progress Against Leukemia

1980–1989Late 1980s: Benzene established to cause cancer

Progress Against Leukemia

1990–1999

Progress Against Leukemia

1990–19991995: Lymphocyte transfusions re-induce leukemia remissions

1995: Approval of tretinoin leads to 95 percent cure rate for rare leukemia

Progress Against Leukemia

2000–Present

Progress Against Leukemia

2000–Present2000: Fludarabine works faster, better for patients with CLL

Progress Against Leukemia

2000–Present2001: New targeted therapy – imatinib – proven effective against chronic myelogenous leukemia

Progress Against Leukemia

2000–Present2004, 2006: Epigenetic drugs approved to prevent cancer in patients with myelodysplastic syndromes

Progress Against Leukemia

2000–Present2005: Drug approved to reduce oral sores caused by cancer treatment

Progress Against Leukemia

2000–Present2006: New drug helps CML patients who become resistant to imatinib

Progress Against Leukemia

2000–Present2007: Addition of an arsenic compound found to improve survival for rare form of leukemia

2007: Study supports expanded use of dasatinib for CML

2007: Bendamustine is effective against chronic lymphocytic leukemia (CLL)

Progress Against Leukemia

2000–Present2009: Genome of acute myelogenous leukemia is sequenced

Progress Against Leukemia

2000–Present2010: Tyrosine kinase inhibitors provide additional options for CML

2011: Adding rituximab extends survival for chronic lymphocytic leukemia

Progress Against Leukemia

Five-Year Survival

29

34

39

44

49

54

59

1975

1977

1979

1981

1983

1985

1987

1989

1991

1993

1995

1997

1999

2001

2003

2005

2007

2009

Year of Diagnosis

% o

f Pa

tien

ts S

urv

ivin

g F

ive

Ye

ars

Source: National Cancer Institute

Progress Against Leukemia

Mortality

4

5

6

7

8

9

10

11

12

1970

1972

1974

1976

1978

1980

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

Year of Death

Ca

nce

r D

ea

ths

pe

r 1

00

,00

0 P

eo

ple

Source: National Cancer Institute

Progress Against Leukemia

New Cases

10

11

12

13

14

15

16

17

18

1973

1975

1977

1979

1981

1983

1985

1987

1989

1991

1993

1995

1997

1999

2001

2003

2005

2007

2009

Year of Diagnosis

Ne

w C

an

cer

Ca

ses

pe

r 1

00

,00

0 P

eo

ple

Source: National Cancer Institute

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