ESTIV2014

ESTIV2014

ProgrammeThe 18th International Congress on In Vitro Toxicology ESTIV2014

June 10-13, 2014Egmond aan ZeeThe Netherlands

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Tuesday June 10, 2014

09.00 h Registration opens

09.00-12.20 h 1st NOTOX Satellite Meeting Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures

10.00-12.30 h ESTIV-CAAT-IVTIP Pre-Congress Workshop Industrial and Regulatory Implementation of Non-Animal Integrated Testing Strategies - Progress in skin sensitization and lessons learnt from other areas10.00-10.20 h Thomas Hartung, CAAT, USA Constructing and evaluating Integrated Testing Strategies (ITS) for safety assessment.10.20-10.40 h Joanna Jaworska, P&G, Belgium Practical application of Bayesian Integrated Testing Strategy for Skin Sensitization Potency.10.40-11.00 h Emiel Rorije, RIVM, The Netherlands Use of non-testing, in vitro and weight-of-evidence approaches in an IATA for skin sensitization.11.00-11.20 h Andreas Natsch, Givaudan, Switzerland Predicting skin sensitizing potency based on in vitro data from KeratinoSens™ and kinetic peptide binding: Opportunities and limitations.11.20-11.40 h Dinant Kroese, TNO, Bart van de Burg, BDS, The Netherlands Implementation of an Integrating Testing Strategy for reproductive toxicity from an industrial perspective.11.40-12.00 h Rodger Curren, IIVS, USA Lessons learn from the regulatory implementation of ITS for eye irritation.12.00-12.30 h Round table discussions

12.30-13.15 h Lunch

Programme

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13.15-13.45 h Opening of ESTIV2014 Chantra Eskes (ESTIV) Jan van der Valk (INVITROM, LOC ESTIV2014)

13.45-14.30 h Keynote lecture Paul Jennings, Medizinische Universität Innsbruck, Austria The future of in vitro toxicology.

14.30-15.00 h Coffee Break and Poster Viewing

Session 1: Advanced in vitro models Session chairs: Bob van de Water, Laura Suter-Dick

15.00-15.40 h Bob van de Water, Leiden University, The Netherlands Towards a high-throughput microscopy pathway-in-toxicity platform for chemical safety assessment.15.40-16.00 h Viktoriia Starokozhko, University of Groningen, The Netherlands Precision-cut rat liver slices remain viable in a well plate for up to five days.16.00-16.20 h Patrina Gunness, InSphero AG, Switzerland Detection of drug-induced liver injury with long-term in vitro cultures of 3D human liver microtissues.16.20-16.40 h Cristina Bertinetti-Lapatki, Hoffmann-La Roche, Switzerland Secreted and intracellular microRNAs as biomarkers for hepatic toxicity in vitro.16.40-17.00 h Laura Suter-Dick, FHNW, Switzerland Cytotoxicity, beyond cell death.

17.00-17.30 h ESTIV Annual General Assembly

17.30-18.00 h Poster Viewing

18.00 h Welcome reception

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Wednesday June 11, 2014

Session 2: Body-on-a-chip Session chairs: Andries van de Meer, Jan van der Valk08.30-09.10 h Andries van de Meer, Wyss Institute for Biologically Inspired Engineering, Harvard University, USA Organs-on-Chips and the road towards a Body-on-a-Chip09.10-09.30 h Reyk Horland, TU Berlin, Germany The multi-organ-chip (MOC) - a universal microfluidic platform for long-term tissue maintenance and substance testing.09.30-09.50 h Miyoung Yoon, The Hamner Institutes for Health Sciences, USA Improved in vitro tools to predict metabolism: an essential component in in vitro based risk assessment.09.50-10.10 h Bas Trietsch, Mimetas BV, The Netherlands Organ-on-a-chip platform for high-throughput drug screening.10.10-10.30 h Geny Groothuis, University of Groningen, The Netherlands Building a body-on-a-chip: perspectives and challenges.

10.30-11.00 h Coffee Break and Poster Viewing

Session 3: Stem cell research Session chairs: Paula Alves, Leonora Buzanska11.00-11.40 h Paula Alves, Instituto Biologia Experimental e Tecnológica, Portugal Stem cell derived 3D models for pre-clinical research.11.40-12.00 h Marcel Leist, University of Konstanz, Germany Design principles of time- and concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells.12.00-12.20 h Mark Teunis, University of Applied Sciences, The Netherlands Using cellular signals to assess developmental toxicity of compounds in a mouse embryonic stem cell system.12.20-12.40 h Nitin Telang, Palindrome Liaisons Consultants, USA Cancer initiating stem cells in models for molecular subtypes of breast and colon cancer.

Programme (cont.)

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12.40-13.00 h Robim Rodrigues, Vrije Universiteit Brussel, Belgium Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals.

13.00-14.00 h Lunch and Poster Viewing

Session 4: The new paradigm in toxicological risk assessment Session chairs: Joanna Jaworska, Bas Blaauboer14.00-14.40 h Joanna Jaworska, Procter & Gamble, Belgium Making risk assessments more useful in the time of paradigm change.14.40-15.00 h Anja Wilmes, Medizinische Universität Innsbruck, Austria Integrated omics and biokinetics analysis of cisplatin-induced cell stress in human renal proximal tubule cells.15.00-15.20 h Reiko Kiwamoto, Wageningen UR, The Netherlands QSAR-based physiologically based in silico models suggest negligible DNA adduct formation by 18 food-borne acyclic a,b- unsaturated aldehydes.15.20-15.40 h Valentina Galbiati, Università degli studi di Milano, Italy Role of ROS and HMGB1 in chemical allergen-induced IL-18 production in human keratinocytes.15.40-16.00 h Rebecca Clewell, The Hamner Institutes for Health Sciences, USA Can cancer safety assessment be conducted solely on the basis of in vitro studies?

16.00-16.30 h Coffee Break and Poster Viewing

Student session 116.30-18.00 h Job opportunities and career exploration Session chairs: Greet Schoeters, Mathieu Vinken

18.30- Congress Dinner and After-Party

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Thursday June 12, 2014

Session 5: New molecular biotechnology in toxicology Session chairs: Johannes Grillari, Mathieu Vinken08.30-09.10 h Johannes Grillari, University of Natural Resources and Life Sciences, Vienna, Austria Urine derived human cells as model systems in toxicology.09.10-09.30 h Jennifer Bolleyn, Free University Brussels, Belgium Potential role of microRNA-34a in the regulation of hepatocyte nuclear factor 4a expression in primary rat hepatocytes.09.30-09.50 h Giel Hendriks, Leiden University Medical Center, The Netherlands The ToxTracker assay: Unveiling the carcinogenic properties of chemicals.09.50-10.10 h Alice Limonciel, Innsbruck Medical University, Austria Molecular mechanisms of toxicity and cellular stress responses in renal cells unveiled by integration of transcriptomics, epigenomics, proteomics and metabolomics.10.10-10.30 h Martje de Groot, Institute for Risk Assessment Sciences, The Netherlands Development of calcium responses and electrical activity in differentiating mouse neural progenitor cells in vitro.

10.30-11.00 h Coffee Break and Poster Viewing

Session 6: Nanotoxicology Session Chairs: Armelle Baeza-Squiban, Sjeng Horbach11.00-11.40 h Armelle Baeza-Squiban, Laboratoire des Réponses Moléculaires et Cellulaires aux Xénobiotiques (RMCX), Université Paris Diderot, France Key questions in nanotoxicology.11.40-12.00 h Magdiel Inggrid Setyawati, National University of Singapore, Singapore Nanoparticles disrupt inter-endothelial interactions: Unexpected toxicity and damage to endothelial function.

Programme (cont.)

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12.00-12.20 h Quaiser Saquib, King Saud University, Saudi Arabia Toxicogenomic investigation on nickel oxide nanoparticles (NiO- NPs): Connections among gene function, DNA damage and cell death.12.20-12.40 h Rajiv Saxena, South Asian University, India Modulation of antigen presentation and T cell responses by poly- dispersed single walled carbon nanotubes.12.40-13.00 h Freya Joris, Ghent University, Belgium A comparison of iron oxide nanoparticle induced toxicity in stem cells, a long-lived cell line and a cancer cell line.

13.00-14.00 h Lunch and Poster Viewing

14.00-15.00 h Special event: Debate Debate between Marianne Kuil and Paul Jennings. The central question will be: Can we get rid of animal experimentation in toxicology within five years? Discussion leader: Bas Blaauboer

15.00-15.30 h Coffee Break and Poster Viewing

15.30- Social programme Visit to Alkmaar and Dinner on the Beach

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Friday June 13, 2014

Student session 2: Young speaker session Chairs: Leonora Buzanska, Maria Laura Scarino08.30-08.50 h Lydia Aschauer, Medical University Innsbruck, Austria Loss of specific proximal tubule differentiation biomarkers as markers of tissue-specific sub-lethal chemical induced injury.08.50-09.10 h Alazne Domínguez, Gaiker-IK4, Spain Permeability and toxicological profiles of targeted nanoparticles in blood-brain barrier in vitro models for brain drug delivery.09.10-09.30 h Sjors Schulpen, National Institute for Public Health and the Environment (RIVM), The Netherlands Effects of carbamazepine and valproic acid on gene expression in a human embryonic stem cell based assay for neuro- developmental toxicity.09.30-09.50 h Marije Strikwold, Wageningen University, The Netherlands Assessment of potential embryotoxicity of a series of p-substituted phenols by an integrated QSAR-in vitro-PBK approach.

09.50-10.20 h Coffee Break and Poster Viewing

Session 7: Regulatory in vitro toxicology Session Chairs: Sandra Coecke, Chantra Eskes10.20-11.00 h Sandra Coecke, European Commission for Validation of Alternative Methods, Italy Considerations in the development and implementation of in vitro methods intended for regulatory use: GIVIMP11.00-11.20 h Harvey Clewell, The Hamner Institutes for Health Sciences, USA Moving toward increased use of in vitro data in regulatory toxicology.11.20-11.40 h Cyrille Krul, University of Applied Sciences, The Netherlands SLiM: a smart way from innovations to humans.

Programme (cont.)

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11.40-12.00 h Katharina Guth, BASF SE Experimental Toxicology and Ecology, Germany In-house post-validation of the in vitro skin sensitization testing strategy using ‘real-life’ compounds.12.00-12.20 h George DeGeorge, MB Research Laboratories, USA The Replacement Ocular Battery (ROBatt): An Integrated Testing Strategy for ocular irritation classification.12.20-12.40 h Chantra Eskes, SeCAM Services & Consultation on Alternative Methods, Switzerland Validation study on the Ocular Irritection® assay for eye irritation testing.12.40-13.00 h Iwona Wilk-Zasadna, EURL ECVAM, Italy Validation of bio-analytical methods applied to measure concentration of chemicals in biological matrices

13.00 h Closing ceremony of ESTIV2014

ESTIV2014

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