29-30 November 2013, She�eld, UKOrganizers: D. Farge-Bancel, J. Snowden

Final Programme

EBMT Autoimmune Diseases Working PartyEducational Meeting

Including a joint symposium withthe UK Scleroderma Group

Introduction

Dear Colleagues,

This two day educational meeting will cover di�erent topics related to HSCT and other cellular therapies for severe autoimmune diseases. The �rst day will be devoted to systemic sclerosis and organised jointly with the UK Scleroderma Group. The second day is devoted to neurological and gastroenterological diseases. Both days will also have elements of basic science relating to cellular therapy in autoimmune diseases.

Attendance from many di�erent specialists and scienti�c colleagues is expected, and we hope this unique collaborative meeting will generate ongoing 'cross-fertilization' of ideas for the future development of our specialities.

Best Regards,

Dominique Farge-Bancel and John Snowden

Aims of the Meeting:Course Faculty

:

The participants of the educational eventwill gain knowledge of:

Dominique Farge-BancelJohn SnowdenDavid AbrahamMohammed AkilTobias AlexanderAttilio BondanzaMaya BuchRichard BurtGerry CoghlanThomas DaikelerChris DentonFiona DignanRafella GrecoChris Hawkey

Chris HewittBernd HohensteinArianne HerrickMajid KazmiDavid KielyKatarina LeBlancAlan LoboMaria Carolina OliveraMontserrat RoviraRiccardo SaccardiBasil SharrackPam ShawPeter Taylor

1. Standard and cellular therapeutic approaches to severe systemic sclerosis

2. Assessment of the severe systemic sclerosis patient

3. Systemic sclerosis and graft-versus-host disease: similarities and di�erences

4. Cellular therapy for neurological diseases

5. Cellular therapy for in�ammatory bowel disease

6. Mechanisms of action of HSCT and cellular therapy in autoimmune diseases

7. Future directions in cell therapy for autoimmune diseases

Session I: Severe systemic sclerosis: revised pathophysiology, Chairs: J.Snowden, M. Akil re�ned evaluation and current standard immunosuppressive approaches

C. DentonNew perspectives for the physiopathology of systemicsclerosis: lessons from graft-versus-host disease (GvHD)

11.10 - 11.30

A. HerrickThe ESOS study11.50 - 12.10

G. Coghlan, D. KielyThe importance of cardiopulmonary evaluation insystemic sclerosis

11.30 - 11.50

Session II: Hematopoietic stem cell transplantation for systemic sclerosis Chairs: R. Saccardi, M. Buch

R. BurtNorthwestern University experience in systemic sclerosis12.10 - 12.30

M.C. OliveraRibeirão de Preto - University of São Paulo experience12.45 - 13.05

D. Farge, J. van Laar, A. TyndallASTIS trial12.30 - 12.45

D. AbrahamExperimental models of systemic sclerosis: relevanceto graft-versus-host disease (GvHD)

14.20 - 14.35

F. DignanThe HSCT expert’s perspective14.35 - 14.55

P. TaylorExtracorporeal Photopheresis (ECP): from graft-versus-hostdisease to SSc

16.00 - 16.20

D. Farge16.40 - 17.00

T. AlexanderImmune reconstitution after HSCT for autoimmunediseases: from current experience to standardization

16.20 - 16.40

Co�ee Break15.30 - 16.00

Session III: Systemic sclerosis and graft-versus-host disease: Chairs: C. Denton, M. Rovirasimilarities and di�erences

Session IV: Future directions for severe systemic sclerosis Chairs: R. Burt, C. Denton

Programme

UK Scleroderma Group Business Meeting10.00 - 11.00

Day 1 - Friday 29th November

Lunch13.05 - 14.20

C. Denton, D. Farge, J. SnowdenWelcome and introduction11.00 -11.10

A. Bondanza15.10 - 15.25

T. DaikelerSkin histology after HSCT in systemic sclerosis14.55 - 15.10

Biomarkers in graft-versus-host disease (GvHD)

HSCT and/mesenchymal stem cells for the systemic sclerosis specialist

D. Farge, C. Denton, J. Snowden17.15 - 17.30

J. SnowdenQuality and safety of HSCT in autoimmune diseases17.00 - 17.15

Discussion, close and thanks

Registration, arrivals and co�ee for other participants10.00 - 11.00

Programme

Day 2 - Saturday 30th November

Lunch13.00 - 14.00

Session V: Cellular and immune therapies for neurological diseases Chairs: K. LeBlanc, B. Sharrack

R. SaccardiHSCT and mesenchymal stem cells for multiple sclerosis 10.30 - 10.50

R. GrecoNeuromyelitis optica (NMO)11.10 - 11.25

P. Shaw, C. HewittMotor neurone disease: is there a role for stem celltransplantation?

10.50 - 11.10

Session VI: In�ammatory bowel disease Chairs: M. Kazmi, A. Lobo

C. HawkeyRandomised clinical trials of HSCT: what can we learnfrom the ASTIC study?

14.00 - 14.15

M. RoviraPractical challenges in autologous HSCT for Crohn’s disease:the haematologist’s perspective

14.15 - 14.30

D. Farge, J. Snowden, M. Badoglio

ADWP Business meeting08.30 - 10.00

M. KazmiChronic in�ammatory demyelinating polyneuropathy (CIDP)11.25 - 11.40

R. BurtNorthwestern University experience in multiple sclerosis11.40 - 12.10

Co�ee Break10.00 - 10.30

Session VII: Future Directions in HSCT and cellular therapy in Chairs: C. Hawkey, D. Farge autoimmune diseases

T. Alexander, A. BondanzaRebooting dysfunctional immune systems with HSCT:from bench to beside

14.30 - 14.55

K. LeBlanc, J.Snowden, D. Farge15.15 - 15.30

K. LeBlancThe future of cellular therapy for immunomodulation: fromgraft-versus-host disease to autoimmune diseases

14.55 - 15.15

Discussion: Future grant applications for cell therapy inautoimmune diseases: the EBMT perspectives

Close16.00

B. HohensteinImmunoabsorption as an alternative approach for thetreatment of autoimmune diseases of the nervous system

12.10 - 12.30

R. Saccardi, B. SharrackPanel Discussion12.30 - 12.55

Complementary Programme

Informal dinner - Friday 29th November

Traditional British dishes and real ale tasting at the Cricket Inn - coaches from course venue19.30 - 22.30

Venue

EBMT-ED is the educational branch of the European Group for Blood and Marrow Transplantation

Registration

www.ebmt.org/ADWP2013

conferences@she�eld.ac.uk

The venue for the course is as follows:

‘The Edge’University of She�eld34 Endcli�e CrescentShe�eld, S10 3EDUnited Kingdom

For more information on the dinner venue, please consult: www.cricketinn.co.uk

For international participants, She�eld can be reached easily via Manchester Airport which has direct hourly trains from the airport station. The train route takes you through the beautiful Peak District National Park.

Registration for the course can be carried out at the following link:

Participants can choose to register for either one or both of the educational days. They can also register for an optional informal dinner on the evening of Friday 29th November.

There is a separate registration fee for each of the educational days and the dinner. Each costs £40.

If you are interested in booking accommodation, the University has a boutique hotel very close to the venue called the Halifax Hall Hotel. They o�er a very competitive price of £55 + VAT for bed and breakfast.

To book your stay at the Halifax Hall Hotel, send an email to the following address, clearly stating that you are attending the ’EBMT event’: