Pioneering the Future: Innovations and Strategies for Preventing

Chemotherapy-Induced Nausea and Vomiting

Program Goals

The Importance of Controlling Nausea and Vomiting in the Setting

of Chemotherapy

CINV: Consequences

Emetogenicity of IV Chemotherapy

Emetogenicity of Oral Chemotherapy

Types of CINV

Neurotransmitters Involved in Emesis

Major Classes of Antiemetic Agents: Definitions

Pharmacokinetic and Physiological Differences Among 5-HT3 RAs

CINV Clinical Practice GuidelinesRecommendations and Related Evidence

HEC: Guideline Recommendations

Olanzapine + PALO + DEX vs APR + PALO + DEX: Efficacy

Olanzapine + PALO + DEX vs APR + PALO + DEX: Safety

MEC: Guideline Recommendations

PALO + DEX vs GRN + DEX in Chemotherapy-Naive Patients Receiving Cisplatin (≥ 50 mg/m2)

or AC-Based Chemotherapy

Gaps/Goals: MEC and HEC Settings

Should DEX be Administered on Days 1-3 or Day 1 Only When Given

in Combination With PALO?

Assessing the Efficacy of Single-dose DEX in Chemotherapy-Naive

Patients Receiving AC-Based Chemotherapy

Steroid Sparing in Non-AC MEC: Efficacy

Steroid Sparing in Non-AC MEC: Treatment-Related AEs

Emerging Treatments for Preventing CINV

5-HT3 RAs

NK-1 RAs: Available Formulations

Investigational NK-1 RAs

Phase 2 Trial: Rolapitant (200 mg oral) + OND + DEX in

Chemotherapy-Naive Patients Receiving HEC

Oral NEPA + Oral DEX vs Oral PALO + Oral DEX in AC-Based MEC: Multinational, Randomized,

Double-Blind Phase 3 Study

NEPA + DEX vs PALO + DEX in AC-Based MEC: Efficacy Outcomes

NEPA + DEX vs PALO + DEX in AC-Based MEC: Safety

NEPA: Phase 2 Netupitant Dose-Finding Study

Study Design

NEPA: Phase 2 Netupitant Dose-Finding StudyOverall CR Rates

NEPA: Phase 2 TrialSecondary Efficacy Endpoints

NEPA in Multicycle MEC and HEC: Multicenter, Randomized, Double-

blind, Phase 3 Study

NEPA in Multicycle MEC and HEC: Overall CR Rates

NEPA in Multicycle MEC and HEC: Most Common AEs

Innovations and Strategies in the Prevention of CINV: Summary

Abbreviations

Abbreviations (cont)

References

References (cont)

References (cont)

References (cont)

References (cont)

References (cont)

References (cont)

References (cont)

References (cont)