Wednesday, January 20 To

Friday, January 23, 2016

Reitz Union Auditorium and Grand Ballroom University of Florida, Gainesville, FL USA

PROGRAM BOOK

ADVANCES IN SKELETAL MUSCLE BIOLOGY IN HEALTH AND DISEASE

UNIVERSITY of FLORIDA

The Conference organizers gratefully acknowledge the financial Support of :

ADVANCES IN SKELETAL MUSCLE BIOLOGY IN HEALTH & DISEASE Sponsors

The Neuromuscular Plasticity Training Program NIH/NICHD T32 HD043730 Department of Physical Therapy UNIVERSITY of FLORIDA

2016 ADVANCES IN SKELETAL MUSCLE BIOLOGY IN HEALTH AND DISEASE CONFERENCE PROGRAM

Wi-Fi: The University of Florida offers complimentary internet access to people affiliated or conducting business with UF and UFHealth via “ufvisitor”. To connect please select “ufvisitor”, open up an internet browser window and follow the instruction. The conference organizers are unable to provide further assistance with connectivity. WEDNESDAY, JANUARY 20 Auditorium, Reitz Union, University of Florida Time 1:30pm Welcome and Opening Remarks Michael Good Dean, College of Medicine

Andrew Judge Associate Professor Scott Powers UAA Endowed Professor and Distinguished Professor

1:45pm Introduction to the UF Myology Institute Lee Sweeney Director, Myology Institute 1:55pm Institut de Myologie Gillian Butler Browne Université Pierre et Marie Curie 2:00pm Session Muscle Diseases: Biology & Biomarkers Chair Lee Sweeney 2:00-2:25 Gillian Butler Browne Novel Biomarkers for Neuromuscular Disease Université Pierre et Marie Curie 2:25-2:50 Jim Tidball Klotho Gene Silencing Promotes Pathology in University of California, Muscular Dystrophy

Los Angeles 2:50-3:15 Isabelle Richard Gene Transfer in Limb-girdle Muscular Dystrophies Genethon 3:15-3:40pm Coffee Break and Poster Viewing - Coffee, tea, and light snacks provided

Chair Glenn Walter

3:40-4:05 Ashok Kumar TRAF6/TAK1 Signaling in Satellite Stem Cell University of Louisville Homeostasis 4:05-4:30 D. Cornelison Who are You Calling Repulsive? Eph/Ephrin University of Missouri Signaling in Muscle Patterning 4:30-4:55 Rich Lovering Susceptibility to Injury in Dystrophic Muscle University of Maryland 4:55-5:55 Trainee Poster Abstract data blitz – 4 min presentations with no questions

Chair Andrew Judge

Poster #24. Manganese Enhanced MRI (MEMRI): A Novel, Non-Invasive Approach to Assess Skeletal Muscle Pathology in mdx Mice. Loehr, James A; Stinnet, Gary R; Pautler, Robia G; Rodney, George G. Poster #29. Multiscale Computational Models Recapitulate Progression of Fibrosis in Dystrophic Muscle. Virgilio, Kelley M; Martin, Kyle S; Peirce, Shayn M; Blemker, Silvia S. Poster #41. Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Ebert, Scott; Dyle, Michael; Bullard, Steven; Dierdorff, Jason; Murry, Daryl; Fox, Daniel; Bongers, Kale; Lira, Vitor; Meyerholz, David; Talley, John; Adams, Christopher. Poster #60. Causative Role of MEF2C in Pre-Cachectic Downregulation of Muscle Structural Genes and Muscle Atrophy During Cancer Cachexia. Nosacka, Rachel L; Judge, Sarah M; Delitto, Dan; Nosacka, Rebecca M; Trevino, Jose G; Judge, Andrew R.

Poster #69. Inhibition of MEK Rescues Cancer Cachexia via a Tumor Extrinsic Effect. Talbert, Erin E; Yang, Jennifer; Lesinski, Gregory B; Guttridge, Denis C. Poster #75. Targeting Src Kinase and the Microtubule Network in the Treatment of Duchenne Muscular Dystrophy. Abo-Zahrah, Reem; Pal, Rituraj; Loehr, James A; Monroe, Tanner; Hall, Benjamin; Rodney, George G. Poster #83. A Role for Rheb and TSC2 in the Mechanical Activation of mTOR Signaling. Jacobs, Brittany L; McNally, Rachel M; Kim, Kookjoo; Hornberger, Troy A. Poster #95. Alterations in the Muscle Force Transfer Apparatus in Aged Rats during Unloading and Reloading. Hughes, DC; Marshall, AG; West, DWD; Baehr, LM; Marcotte, GR; Davidyan, A; Bodine, SC; Baar, K.

Poster #98. Skeletal Muscle Compensates for Loss of Brown Adipose Tissue During Cold-Induced Thermogenesis. Bal, Naresh C; Maurya, Santosh K; Singh, Sushant; Rowland, Leslie A; Periasamy, Muthu. Poster #103. GLUT4 is Not Necessary for Overload-Induced Glucose Uptake in Mouse Skeletal Muscle. McMillin, Shawna; Schmidt, Denise; Ferey, Joshua; Kahn, Barbara; Witczak, Carol. Poster #120. Autophagy Response Plays an Important Role in Muscle Regeneration. Nichenko, AS; Southern, WM; Call, JA. Poster #128. CaMKKα Regulates the Pentose Phosphate Pathway in Mouse Skeletal Muscle. Ferey, Jeremie LA; Schmidt, Denise; Ferey, Joshua; Smith, Brandon; Means, Anthony R; Witczak, Carol A

Poster #131. Phosphatidylserine Decarboxylase Regulates Skeletal Muscle Respiration by its Action on Complex II. Heden, Timothy D; Funai, Katsuhiko

Poster #141. Inhibition of Toll-Like Receptor 4 Does Not Prevent Palmitate-Induced Endoplasmic Reticulum Stress in Cultured Skeletal Muscle Cells. Perry, Ben; Rahnert, Jill; Zheng, Bin; Price, S Russ

6:00pm Myology Institute Reception Grand Ballroom

THURSDAY, JANUARY 21 Auditorium, Reitz Union, University of Florida Time 7:40am Coffee, Tea, and Pastries 8:00-9:00am Grant Workshop: Insight into Successful NIH Award Applications - A

Reviewers Perspective Chair Thomas Clanton

8:00-8:15 Askok Kumar F grants University of Louisville 8:15-8:30 Karyn Esser K grants University of Florida 8:30-8:45 Lee Sweeney R grants University of Florida 8:45-9:00 Open Panel Discussion 9:15-10:45am Session Muscle Wasting, Cachexia and Sarcopenia Chair Chris Adams 9:15-9:40 David Glass Signaling Pathways Regulating Skeletal Muscle Novartis Institutes for Function

Biomedical Research 9:40-10:05 Srinivasan Dasarathy Sarcopenia in Cirrhosis-Mechanisms and Mediators Cleveland Clinic 10:05-10:30 Sue Bodine Age-related Deficits in Skeletal Muscle Recovery

University of California, Davis Following Disuse: Role of Denervation and Impaired Proteostasis

10:30-10:45 Scott Powers Ventilator-induced Diaphragmatic Dysfunction

University of Florida 10:45-11:10am Coffee Break and Poster Viewing - Coffee, tea, and light snacks provided Chair Teresa Zimmers 11:10-11:35 Denis Guttridge Muscling in on Alternative NF-κB as a Regulator of The Ohio State University Oxidative Metabolism 11:35-12:00 Jim Carson Understanding Muscle gp130 Receptor’s Role in

University of South Carolina Cancer-induced Muscle Wasting: Interactions with Sex and Exercise

12:00-12:15 Andrea Bonetto New Insights into Chemotherapy-related Indiana University Muscle Atrophy and Fatigue

12:15-1:55pm Poster Session I – Grand Ballroom Boxed lunches provided

2:00-3:40pm Session Muscle Metabolism Chair Bret Goodpaster 2:00-2:25 Laurie Goodyear Novel mechanisms regulating muscle metabolism Joslin Diabetes Center 2:25-2:50 Matthew Merritt Measuring Metabolic Flux in Living Systems: A Goal

University of Florida for 2030 2:50-3:15 David Wasserman The Path to Muscle Insulin Resistance goes Through Vanderbilt University Integrin Signaling 3:15-3:40 Jules Griffin Metabolomic Tools for Understanding Muscle University of Cambridge Function in Health and Disease 3:40-4:05pm Coffee Break and Poster Viewing - Coffee, tea, and light snacks provided

4:05-6:00pm Session Muscle Force Transmission and EC-Coupling Chair Michael Reid 4:05-4:30 Andrew Coggan Dietary Nitrate and Muscle Speed and Power in Washington University School Humans

of Medicine in St. Louis 4:30-4:55 Henk Granzier Roles of Giant Proteins Titin and Nebulin in Striated University of Arizona Muscle Health and Disease 4:55-5:20 Lee Sweeney Ameliorating the Consequences of the Loss of University of Florida Dystrophin 5:20-5:45 Siegfried Labeit The Titin Filament in Disease and Therapy University of Heidelberg 7:00pm Dinner at the Swamp Restaurant;

The speakers will be dining at the Swamp Restaurant and we encourage all attendees to dine there also so that informal interactions can continue.

FRIDAY, JANUARY 22 Auditorium, Reitz Union, University of Florida Time 7:45 am Coffee, Tea, and Pastries 8:00-10:05am Session Exercise and Skeletal Muscle Plasticity Chair Leonardo Ferreira 8:00 - 8:25 Karyn Esser Metabolism in Skeletal Muscle, Endogenous University of Florida Clock vs. Behavior 8:25- 8:50 Karyn Hamilton Maintaining Muscle Proteostasis—An Exercise Colorado State University in Slowing Aging 8:50-9:15 Patricia Brum Effects of Aerobic Exercise Training on Heart University of São Paulo Failure-induced Skeletal Myopathy

9:15- 9:40 Justin Percival Physiological Roles for Nitric Oxide in Skeletal Muscle University of Miami Contractility and Bioenergetics 9:40-10:05 Esther Dupont-Versteegden Reduced Voluntary Wheel Running in Satellite Cell

University of Kentucky Depleted Mice: from Muscle Adaptation to Impaired Coordination

10:05 – 11:50am Poster Session II– Grand Ballroom

Coffee, tea, and light snacks provided followed by boxed lunches 11:50-1:55pm Session Muscle Hypertrophy, mTOR Signaling and Mechanotransduction Chair Sue Bodine 11:50-12:15 Beth Barton Separating Anabolic and Metabolic Actions of IGF-I in University of Florida Muscle 12:15-12:40 Blake Rasmussen Nutrient Sensing in Aging Skeletal Muscle University of Texas Medical Branch

12:40-1:05 Marni Boppart Integrin Regulation of Skeletal Muscle Signaling and

University of Illinois, Growth Urbana-Champaign

1:05-1:30 Scot Kimball Leucine Modulates mTORC1 Signaling by Acting

Pennsylvania State University Specifically to Alter the Phosphorylation Status of Sestrin2

1:30-1:55 Marta Fiorotto Adult Skeletal Muscle Phenotype: Does it Matter Baylor College of Medicine What Your Mother Fed You? 1:55 – 2:15pm Coffee Break - Coffee, tea, and light snacks provided

2:15-4:00pm Session Mitochondria and Redox Biology Chair Scott Powers 2:15-2:40 Holly Van Remmen Mitochondrial Dysfunction and ROS Generation

Oklahoma Medical Research in Muscle Atrophy Foundation

2:40-3:05 David Marcinek Targeting Mitochondria to Improve Aged Skeletal University of Washington Muscle Function 3:05-3:30 Lauren Sparks Exercise Resistance: Are Some Individuals Translational Research Institute Programmed to Fail?

for Metabolism and Diabetes 3:30-3:55 Russ Hepple Mitochondrial-mediated Apoptosis in Aging Muscle McGill University 4:00pm Farewell

Scientific Organizers

Andrew Judge, Department of Physical Therapy, University of Florida

Leonardo Ferreira, Department of Applied Physiology & Kinesiology, University of Florida

Scott Powers, Department of Applied Physiology & Kinesiology, University of Florida

Glenn Walter, Department of Physiology & Functional Genomics, University of Florida

Sue Bodine, Department of Neurobiology, Physiology and Behavior, UC, Davis

Administrative Organizer

Christa Stout, Myology Institute, University of Florida

ABSTRACTS/POSTERS Please refer to the number of your poster to locate the board where your poster can be displayed.

Muscle Diseases: Biology and New Biomarkers

1. Effect of Obesity on Disease Progression in Boys with Duchenne Muscular Dystrophy Over 1-year Period Alabasi, Umar; Willcocks, Rebecca ; Forbes, Sean ; Triplett, Bill; Rooney, William; Wang, Dah-Jyuu; Lott, Donovan; Finkel, Richard; Tennekoon, Gihan; Finanger, Erika; Russman, Barry; Byrne, Barry; Walter, Glenn; Sweeney, Lee; Vandenborne, Krista 2. Longitudinal Changes in Function in Ambulatory Boys With Duchenne Muscular Dystrophy Arora, Harneet; Willcocks, Rebecca J; Lott, Donovan J; Harrington, Ann T; Senesac, Claudia R; Zilke, Kirsten L; Tennekoon, Gihan I; Finanger, Erika L; Finkel, Richard S; Triplett, William T; Byrne, Barry J; Walter, Glenn A; Sweeney, H Lee; Vandenborne, Krista 3. RAN Translation in Huntington Disease Bañez-Coronel, Monica; Ayhan, Fatma; Tarabochia, Alex D; Zu, Tao; Perez, Barbara A; Tusi, Solaleh Khoramian; Pletnikova, Olga; Borchelt, David R; Ross, Christopher A,; Margolis, Russell L; Yachnis, Anthony T; Troncoso, Juan C; Ranum, Laura PW 4. Magnetic Resonance Measures are Correlated to Functional Ability in Duchenne Muscular Dystrophy Barnard, Alison M; Willcocks, Rebecca J; Finanger, Erika L; Triplett, William T; Rooney, William D; Lott, Donovan J; Wang, Dah-Jyuu; Senesac, Claudia R; Forbes, Sean C; Tokay Harrington, Ann; Finkel, Richard S; Russman, Barry S; Byrne, Barry J; Tennekoon, Gihan I; Walter, Glenn A; Sweeney H Lee; Vandenborne, Krista 5. Effects of a PDE5A Inhibitor on Muscle Damage and Performance During Progressive Low-intensity Treadmill Training in mdx Mice Batra, A; Vohra, R; Chrzanowski, S; Lott, DJ; Walter, GA; Vandenborne, K; Forbes, SC 6. On the Rate of Synthesis of Individual Proteins Within and Between Different Striated Muscles of the Rat Burniston, JG; Hesketh, S; Srisawat, K; Sutherland, H; Jarvis, JC 7. Evidence of Hypoxic Tolerance in Respiratory Muscles from Young mdx Mice Burns, David P; O'Halloran, Ken D 8. Autophagy Disruption Abolishes β2-Adrenoceptor Agonist Benefits in Dysfunctional Skeletal Muscle Campos, JC; Voltarelli VA; Bechara, LRG; Moreira, JBN; Baerh LM; Brum, PC; Bodine SC; Ferreira JCB

9. Looking at Muscle Damage in a New Light Chrzanowski, SM; Batra, A; Lee, BA; Vohra, R; Forbes, SC; Vandenborne, K; Walter, GA 10. Inhibition of Neutral Sphingomyelinase Prevents Diaphragm Weakness and Ventilatory Abnormalities in Chronic Heart Failure Coblentz, Philip; Ahn, Bumsoo; Patel, Nikhil; Hayward, Linda F; Yoo, Jeung-Ki; Christou, Demetra; Ferreira, Leonardo F

11. Restoration of TAZ Gene Expression and Function by AAV-DES-TAZ Delivery for the Correction of Barth Syndrome in vitro Donate, AL; Soustek, M; Rizzo, S; Ramanathan, M; Gosiker, BJ; Lewin, AS; Byrne, BJ; Pacak, CA 12. Satellite Cell Activation is Adversely Affected in Type 1 Diabetic (T1D) Skeletal Muscle as a Result of the Hyper-Activation of Notch Signalling D’souza, Donna M; Hawke, Thomas J 13. Skeletal Muscle Exosome Responses to Acute Aerobic and Aerobic + Resistance Exercise Garner, RT; Weiss, JA; Nie, Y; Solfest, JS; Gavin, TP 14. The Establishment Postnatal-Like Myotubes in vitro for the Functional Dissection of Muscle Innate Immunity Goulding, Leah V; Chang, Kin-Chow 15. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts Hammers, David W; Sleeper, Margaret M; Forbes, Sean C; Shima, Ai; Walter, Glenn A; Sweeney, H Lee

16. Disease Modifying Effects of CAT-1041, a Novel NF-κB Inhibitor, on Dystrophinopathic Muscle Hammers, DW; Sleeper, MM; Forbes, SC; Pham, J; Bemis, J; Milne, JC; Walter, GA; Jirousek, M; Sweeney, HL

17. Malformed Myofibers have Non-Uniform Stress Distribution with Increased Stress Concentration Iyer, Shama R; Valencia, Ana P; Lovering, Richard M

18. Urine Metabolites as Biomarkers in Duchenne Muscular Dystrophy Lee-McMullen, Brittany; Chrzanowski, Stephen; Willcocks, Rebecca; Lott, Donovan; Senesac, Claudia; Edison, Arthur; Walter, Glenn; Vandenborne, Krista

19. Secreted Chemokine Response to Endotoxin in Mouse Skeletal Muscle Mattingly, AJ; Laitano, O; Welc, SS; Morse, DA; King, MA; Clanton, TL

20. Evaluating Autophagy in Pompe Disease Following Gene Therapy McCall, Angela; Stankov, Sylvia; Falk, Darin; Byrne, Barry 21. PPARγ in Repair Macrophages Controls Gdf3 and Skeletal Muscle Regeneration Varga, T; Mouinier, R; Patsalos, A; Peloquin, M; Brown, C; Chazaud, B; Nagy, L 22. Skeletal Muscle-Derived Exosomes Regulation of Endothelial Cell Function Nie, Yaohui; Sato, Yoriko; Gavin, Timothy P 23. Identification of Causal Mutations Using Exome Sequencing in LGMD Families from the United States Reddy, Hemakumar M; Cho, Kyung-Ah; Lek, Monkol; Estrella, Elicia; Jones, Michael; Darras, Basil T; Lidov, Hart GW; Brownstein, Catherine A; Margulies, David M; Yu, Timothy W; Kunkel, Louis M; MacArthur, Daniel G; Kang, Peter B

24. Manganese Enhanced MRI (MEMRI): A Novel, Non-Invasive Approach to Assess Skeletal Muscle Pathology in mdx Mice Loehr, James A; Stinnet, Gary R; Pautler, Robia G; Rodney, George G

25. Dissecting the Role of MEGF10 and Notch in Myoblast Function Saha, Madhurima; Mitsuhashi, Satomi; Reddy, Hemakumar M;Jones, Michael; Pacak, Christina A; Draper, Isabelle; Kang, Peter

26. Autophagy in the Golden Retriever Muscular Dystrophy (GRMD) Dog Stoughton, WB; Balog-Alvarez, C; Kornegay, JN 27. Regulation of Myogenesis by MBNL Proteins Thomas, James; Batra, Ranjan; Scotti, Marina; Llera, Catherine; Bardhi, Olgert; Swanson, Maurice

28. A Novel Model of Pompe Disease with Accelerated Cardiorespiratory Phenotype Todd, A Gary; Vaught, Lauren; Doyle, Brenden; Walter, Glenn A; Notterpek, Lucia; Fuller, David D; Byrne, Barry J; Falk, Darin J 29. Multiscale Computational Models Recapitulate Progression of Fibrosis in Dystrophic Muscle Virgilio, Kelley M; Martin, Kyle S; Peirce, Shayn M; Blemker, Silvia S 30. Bidirectional Transcription and RAN Translation in DM2 Zu, Tao; Cleary, John; Liu, Yuanjing; Banez-Coronel, Monica; Yachnis, Anthony; Ranum, Laura Muscle Wasting, Cachexia and Sarcopenia 31. Failed Reinnervation in Aging Skeletal Muscle is Associated with MicroRNA-Induced Blunting of the Neurotrophin Response Aare, Sudhakar; Spendiff, Sally; Vuda, Madhusudanarao; Perez, Anna; Wu, Qinghua; Hettwer, Stefan; Taivassalo, Tanja; Hepple, Russell T 32. High-Intensity Interval Exercise Training Fully Restores Skeletal Muscle Function During Cancer Cachexia Progression Alves, Christiano; de Almeida, Ney; Tobias, Gabriel; das Neves, Willian; Voltarelli, Vanessa; Brum, Patricia 33. 14 Days of Bed Rest Induces a Decline in Satellite Cell Content and Robust Atrophy of Skeletal Muscle Fibers in Middle-Aged Adults Arentson-Lantz, Emily J; English, Kirk L; Paddon-Jones, Doug; Fry, Christopher S

34. Ptch1 Haploinsufficiency Results in a Hypotrophic Skeletal Muscle Phenotype Au, Ernie D; Zimmers, Teresa A 35. Age-Related Deficits in Skeletal Muscle Recovery Following Disuse are Associated with ER Stress Not Impaired Protein Synthesis Baehr, Leslie M.; West, Daniel W.D.; Marcotte, George; Marshall, Andrea G.; De Sousa, Luis Gustavo; Baar, Keith; Bodine, Sue C.

36. Unfolding Protein Response Pathways Attenuates Skeletal Muscle Wasting in Mouse Models of Cancer Cachexia Bohnert, Kyle; Sato, Shuichi; Xiong, Guangyan; Kumar, Ashok 37. Loss of Adenine Nucleotides Accelerates Protein Degradation but Does Not Activate Autophagic/lysosomal Pathway Miller, Spencer; Davis, Patrick R; Brault, Jeffery J

38. Metabolic Adaptation of Skeletal Muscle to Hyperammonemia Drives the Beneficial Effects of L-Leucine in Cirrhosis Davuluri, Gangarao; Krokowski, Dawid; Guan, Bo-Jhih; Kumar, Avinash; Thapaliya, Samjhana; Singh, Dharmvir; Hatzaglou, Maria; Dasarathy, Srinivasan 39. Hyperammonemia Reduces Skeletal Muscle Protein Synthesis via a β-catenin-c-myc Mediated Impaired Ribosomal Biogenesis Davuluri, Gangarao; Guisto, Michela; Thapaliya, Samjhana; Tran, Uyen; Wessely, Oliver; NagaPrasad, Sathyamangla; Dasarathy, Srinivasan 40. The First Functionally Mature Human Primary in vitro Muscle Model: A New Paradigm to Explore Muscle Physiopathology and Accelerate Drug Discovery for Muscle Disorders Margaron, Yoran; Michaud, Joris; Fernandes, Mathieu; Duchemin-Pelletier, Eve; Pucciarelli, Amélie; Menager, Pauline; Poydenot, Pauline; Degot, Sébastien 41. Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy Ebert, Scott; Dyle, Michael; Bullard, Steven; Dierdorff, Jason; Murry, Daryl; Fox, Daniel; Bongers, Kale; Lira, Vitor; Meyerholz, David; Talley, John; Adams, Christopher 42. Cachexia Mediates Alterations in the Neuromuscular Junction in a Murine Model of Colorectal Cancer Todd, A Gary; Judge, Sarah M; Vaught, Lauren A; Judge, Andrew R; Falk, Darin J 43. Satellite Cell Activation and Apoptosis in Human Skeletal Muscle Following Severe Burn Injury Fry, Christopher S; Porter, Craig; Sidossis, Labros S; Nieten, Christopher; Reidy, Paul T; Rasmussen, Blake B; Lee, Jong O; Suman, Oscar E; Herndon, David N; Finnerty, Celeste C 44. Identification of Dysregulated miRNAs in Skeletal Muscle Paralyzed by Spinal Cord Injury Graham, Zachary A; De Gasperi, Rita; Harlow, Lauren M; Bauman, William A; Qin, Weiping; Cardozo, Christopher P

45. The Effect of IP-10 on the Proliferation and Differentiation of Skeletal Myoblasts Hafen, Paul S; Parmley, Jacob W; Hyldahl, Robert D 46. Angiotensin II Type 1 Receptor Contributes to Ventilator-Induced Diaphragm Dysfunction Hall, Stephanie E; Smuder, Ashley J; Wiggs, Michael P; Morton, Aaron B; Sollanek, Kurt J; Powers, Scott K 47. TAK1 is Required for Growth and Maintenance of Skeletal Muscle Hindi, Sajedah; Sato, Shuichi; Xiong, Guangyan; Kumar, Ashok 48. The Myogenic Relationship of Notch and mTOR Huot, Joshua; Lawrence, Marcus; Peck, Bailey; Marino, Joseph; Arthur, Susan 49. Intermittent Spontaneous Breathing Does Not Cause Mechanical Ventilation-Induced Diaphragm Atrophy and Dysfunction Ichinoseki-Sekine, Noriko; Yoshihara, Toshinori; Tsuzuki, Takamasa; Sugiura, Takao; Powers, Scott; Naito, Hisashi

50. Tumor Cell-Secreted Leukemia Inhibitory Factor (LIF) Causes Atrophy in Mouse and Human Myotubes Jackman, Robert W; Kandarian, Susan C 51. The Physiological Cachexia of Organ Injury and Repair Jiang, Yanlin; Kronbergs, Andris; Liu, Jianguo Liu; Zimmers, Teresa A; Koniaris, Leonidas G

52. Aging-Induced Impairments in Diaphragm Isotonic Contractile Properties and Associated Changes in Proteomic and Sphingolipid Profiles Kelley, Rachel C; McDonagh, Brian; Coblentz, Philip D; Ferreira, Leonardo F 53. Mitochondrial-Mediated Nuclear Apoptosis Tracks Mass Changes of Aging Fast and Slow Twitch Muscles Konokhova, Yana; Thomas, Melissa; Perez, Anna; Picard, Martin; Ritchie, Darmyn; Russell Hepple

54. Effect of Phytoecdysteroid Treatment on Fiber Type Percentage, Myostatin and Atrogenes Expression in Aged Mouse Skeletal Muscle Lawrence, Marcus M; Huot, Joshua R; Sherman, Chase A; Gordon, Scott E; Arthur, Susan T; Shanely, R Andrew; Zwetsloot, Kevin A

55. The AMPK-Related Kinase SNARK Regulates Muscle Mass and Myocyte Survival Lessard, Sarah1,2; Rivas, Donato3; So, Kawai1; Koh, Ho-Jin1,2; Lima Queiroz, Andre1; Hirshman, Michael F1; Fielding, Roger A3; Goodyear, Laurie J1,2

56. Electrical Impedance Myography to Detect Sarcopenia in the C57BL/6J Mouse: Comparisons to Standard Measures Li, Jia; Sanchez, Benjamin; Pacheck, Adam; Yim, Sung; Bouxsein, Mary; Rutkove, Seward 57. Role of Proteasome in Denervated Skeletal Muscle Liu, Haiming1; Ferrington, Deborah2; Thompson, LaDora1

58. Exercise Training in Older Adults Following Hip Fracture Surgery Decreases Expression Level of Skeletal Muscle Genes Associated with Inflammation and Ceramide Biosynthesis Signaling McKenzie, Alec I; Briggs, Robert A; Barrows, Katherine M; Marcus, Robin L; Drummond, Micah J 59. Activin Signaling: A Therapeutic Target for Musculoskeletal Diseases Merscham, Melissa; Hammers, David; Sweeney, Lee 60. Causative Role of MEF2C in Pre-Cachectic Downregulation of Muscle Structural Genes and Muscle Atrophy During Cancer Cachexia Nosacka, Rachel L; Judge, Sarah M; Delitto, Dan; Nosacka, Rebecca M; Trevino, Jose G; Judge, Andrew R

61. Differential Protective Effects of Radix Astragali, Herbal Medicine, on Immobilization-Induced Atrophy of Slow-Twitch and Fast-Twitch Muscles Nozaki, Risa; Takagi, Kana; Nakano, Daiki; Fujii, Takako; Machida, Shuichi 62. Effects of PGC-1α Overexpression on Glucocorticoid-Induced Atrophy Gene Expression in C2C12 Muscle Cells Rahnert, Jill A; Perry, Ben D; Zheng, Bin; Price, S Russ

63. The Regulation of FoxO via HDACS during Cancer Cachexia Roberts, Brandon; Beharry, Adam; Judge, Andrew

64. Tumor Derived IL6 May Promote Skeletal Muscle Atrophy in Pancreatic Cancer Rupert, Joseph E; Jiang, Yanlin; Zhong, Xiaoling; Zimmers, Teresa A

65. Monitoring Distribution of FoxO1-GFP and Atrophy of Skeletal Muscle Fibers in Culture Russell, Sarah J.; Hernandez-Ochoa, Erick; Schneider, Martin 66. Chronic Binge Alcohol Administration Decreases Skeletal Muscle miR-206 in SIV-infected Macaques Simon, Liz; Molina, Patricia 67. Preclinical Characterization of the JAK/STAT Inhibitor SGI-1252 on Skeletal Muscle Functional, Morphological and Myogenic Outcomes Sorensen, Jacob; Fuqua, Jordan; Dehyle, Michael; Parcell, Allen; Groscost, Logan; Hampton, Seth; Bearss, David; Hyldahl, Robert 68. Development of a Selective Androgen Receptor Modulator (SARM) for Skeletal Muscle Wasting and Dysfunction St. Andre, M; Johnson, M; Sun, Y; Chekler, E; Schelling, S; Morris, C; Gilbert, A; Owens, J

69. Inhibition of MEK Rescues Cancer Cachexia via a Tumor Extrinsic Effect Talbert, Erin E; Yang, Jennifer; Lesinski, Gregory B; Guttridge, Denis C 70. Skeletal Muscle Structural and Functional Adaptations to Breast Cancer Treatment in Humans: Possible Role for Oxidative Stress Toth, MJ; Callahan, DM; Miller, MS; Dittus, K 71. Exploring Transcriptional Networks Involved in Mitochondrial Energetics that are Altered with Disuse Atrophy Trevino, Michelle B; Zhang, Xiaolei; Vega, Rick B; Coen, Paul M; Pereira, Suzette L; Tian, M; Kelly, Owen J; Goodpaster, Bret H; Kelly, Daniel P

72. Muscle Dysfunction in Immune Competent Mice with Osteolytic Breast Cancer in Bone is Associated with Skeletal Muscle Oxidation of RyR1 Waning, David L; Mohammad, Khalid S; Mikesell, Carter; Regan, Jenna N; Reiken, Steven; Marks, Andrew R; Guise, Theresa A

73. Distinct Temporal Sequence of Cardiolipin Remodeling, Loss of Mitochondrial Function, and Muscle Atrophy during Hind Limb Unloading Zhang, Xiaolei; Trevino, Michelle; Leone, Teresa C; Vega, Rick; Goodpaster, Bret H; Han, Xianlin; Coen, Paul M

74. Cachexia in Pancreatic Ductal Adenocarcinoma Through a Systemic Activin B Response to Tumor Zhong, Xiaoling; Pons, Marianne; Jiang, Yanlin; Koniaris, Leonidas G; Zimmers, Teresa A

Muscle Hypertrophy, mTOR Signaling and Mechanotransduction 75. Targeting Src Kinase and the Microtubule Network in the Treatment of Duchenne Muscular Dystrophy Abo-Zahrah, Reem; Pal, Rituraj; Loehr, James A; Monroe, Tanner; Hall, Benjamin; Rodney, George G

76. LAT1 Muscle-specific Knockout Impairs Loading-Induced Anabolic Signaling but Not Muscle Protein Synthesis Aguirre, Nicholas; Wallace, Marita; Baar, Keith 77. Oral β-Hydroxy-β-Methylbutyrate Supplementation Enhances Protein Synthesis in Skeletal Muscle of Neonatal Pigs Davis, Teresa; Kao, Michelle; Columbus, Daniel; Suryawan, Agus; Steinhoff-Wagner, Julia; Hernandez-Garcia, Adriana; Nguyen, Hanh; Davis, Steven; Fiorotto, Marta

78. Differential Expression of Amino Acid Transporters During in vitro Myogenesis De Lisio, Michael; Nallabelli, Julian; Niemiro, Grace; Emmons, Russell; Korp, Nicole 79. Postnatal Satellite Cell Proliferation Demonstrates a Specific Requirement for Dietary Protein Fiorotto, Marta; Columbus, Daniel; Steinhoff-Wagner, Julia; Suryawan, Agus; Nguyen, Hanh; Davis, Teresa 80. Dystrophin–Glycoprotein Complex Regulates Muscle Nitric Oxide Production Through Mechanoregulation of AMPK Signaling Garbincius, Joanne F; Michele, Daniel E

81. REDD1 Alters the Rate of Muscle Hypertrophy Following Functional Overload Gordon, Bradley; Nader, Gustavo; Steiner, Jennifer; Jefferson, Leonard; Kimball, Scot 82. Effect of a Lysosomotropic Agent on Amino Acid Sensing Gene Expression in Human Skeletal Muscle Graber, Ted G; Borack, Michael S; Reidy, Paul T; Volpi, Elena; Rasmussen, Blake B

83. A Role for Rheb and TSC2 in the Mechanical Activation of mTOR Signaling Jacobs, Brittany L; McNally, Rachel M; Kim, Kookjoo; Hornberger, Troy A 84. Leucine Modulates mTORC1 Signaling by Acting Specifically to Alter the Phosphorylation Status of Sestrin2 Kimball, Scot R; Gordon, Bradley S; Moyer, Jenna E; Dennis, Michael D; Jefferson, Leonard S 85. MicroRNA-99b Reduces Muscle Protein Synthesis in Human Primary Myotubes Zacharewicz, Evelyn; Kalanon, Ming; Russell, Aaron; Lamon, Severine 86. Optical Coherence Elastography Reveals Fibrosis-Related Changes of Muscle Stiffness in the Diaphragm of Dystrophic Mice Loehr, James A; Wang, Shang; Pal, R; Larina, Irina V; Larin, Kirill V; Rodney, George G 87. Overexpression of the Α7β1 Integrin Influences Expression of Genes which Regulate the Stress Response, Protein Translation, and Substrate Utilization in Mice Mahmassani, Ziad; Pincu, Yair; Munroe, Mike; Boppart, Marni D

88. Inhibition of Degradation Through the Ubiquitin Proteasome Pathway Inhibits Protein Synthesis While Increasing mTORC1 Signaling Marcotte IV, George R; Bodine, Sue; Baar, Keith 89. Raptor is Necessary for the Mechanical Activation of mTOR Signaling McNally, RM; Jacobs, BL; You, J; Goodman, CA; Hornberger, TA

90. p66Shc Regulates Skeletal Muscle Mass Following Functional Overload Wallace, Marita; Aguirre, Nicholas; Saleh, Perrie; Ramsey, Jon; Baar, Keith

91. Dgkζ Mediates Skeletal Muscle Hypertrophy Through a Mechanism Involving Inhibition of the Ubiquitin-Mediated Proteolytic Pathway You, Jae-Sung; Dooley, Matthew S; Kim, Chan-Ran; Anderson, Garrett B; Goodman, Craig A; Hornberger, Troy A

1092. Basal and Stretch-induced Myotube Protein Synthesis Regulation by gp130 Signaling Gao, Song; Carson, James A Muscle Force and EC-Coupling 92. Dithiothreitol Reverses Contractile Dysfunction of Diaphragm Single Fibers Caused by Chronic Heart Failure Ahn, Bumsoo; Ferreira, Leonardo 93. Deficits to Functional and Regenerative Capacity of Skeletal Muscle in TDAG51-/- Mice Coleman, Samantha; Deodhare, Namita; Rebalka, Irena; Gabriel, Gyulay; Austin, Richard; Hawke, Thomas

94. Novel Mechanisms of Muscle Specific Molecular-Clock Output via Transcriptional Regulation of Titin-cap Hodge, BA; Zhang, X; Arnold, N; Esser, KA 95. Alterations in the Muscle Force Transfer Apparatus in Aged Rats during Unloading and Reloading Hughes, DC; Marshall, AG; West, DWD; Baehr, LM; Marcotte, GR; Davidyan, A; Bodine, SC; Baar, K

96. Nonparametric Analysis of Twitch Torque in an mdx Mouse after in vivo Eccentric Injury Sanchez, Benjamin; Iyer, Shama R; Widrick, Jeffrey J; Lovering, Richard M; Rutkove, Seward B

97. Age-Related Changes in the Calcium Response of Single Skeletal Muscle Fibers from Men and Women Straight, Chad R; Ades, Philip A; Toth, Michael J; Miller, Mark S

Exercise and Skeletal Muscle Plasticity 98. Skeletal Muscle Compensates for Loss of Brown Adipose Tissue During Cold-Induced Thermogenesis Bal, Naresh C; Maurya, Santosh K; Singh, Sushant; Rowland, Leslie A; Periasamy, Muthu 99. Dietary Nitrate (NO3-)-Induced Increases in Skeletal Muscle Contractile Function: High vs. Low Responders Coggan, Andrew R; Mikhalkova, Deana; Mahmood, Kiran; Bole, Indra; Leibowitz, Joshua; Kadkhodayan, Ana; Park, Soo; Thomas, Deepak; Thies, Dakkota; Peterson, Linda R 100. CD8+ T-cells Infiltrate Healthy Skeletal Muscle after Exertional Damage to a Greater Degree in Women Deyhle, Michael; Evans, Kaitlyn; Sutton, Chris; Hampton, Seth; Parmley, Jacob; Sorensen, Jacob; Hyldahl, Robert

101. Lack of Regrowth-Promoting Effect of Massage in Aged Rats is Associated with Differential Response of Satellite Cells and Extracellular Matrix Hunt, Emily R; Shah, Aman; Hayek, Amanda M; Confides, Amy L; Abshire, Sarah M; Butterfield, Timothy A; Dupont-Versteegden, Esther E 102. Guiding Muscle Injury Experiments Using an Agent Based Computational Model Martin, Kyle S; Virgilio, Kelley; Passipieri, Juliana A; Kegelman, Chris; Christ, George; Peirce, Shayn M; Blemker, Silvia S 103. GLUT4 is Not Necessary for Overload-Induced Glucose Uptake in Mouse Skeletal Muscle McMillin, Shawna; Schmidt, Denise; Ferey, Joshua; Kahn, Barbara; Witczak, Carol 104. A Comparison of Muscle Protein Content and Protein Synthesis Between Mouse, Rat, Dog, and Human and Cultured Cell Models Miller, Benjamin F; Castor, William M; Hamilton, Karyn L 105. Skeletal Muscle Cellular and Molecular Function Adapt to Resistance Training in a Sex-Specific Manner in Inactive Older Adults Miller, Mark S; Callahan, Damien M; Slauterbeck, James R; Savage, Patrick D; Maughan, David W; Ades, Philip A; Beynnon, Bruce D; Toth, Michael J 106. PGC1α Gene Expression and Blood Flow in a Mouse Model for Cholinergic Deficit Motta-Santos, D; Gomes, MPM; Prado, VF; Prado, MAM; Valdez, G; Barcelos, LS; Lima, LCF; Guatimosim, C; Guatimosim, S

107. Regulation of Long Intergenic Non-Coding RNAs in the Myosin Heavy Chain Gene Locus in Response to Skeletal Muscle Unloading Smith, Derek A; Lowrey, Angela J; Callender, Shelley S; Pandorf, Clay E 108. Exercise Training Following Bed Rest in Older Adults Modulates Skeletal Muscle Anti-Inflammatory (M2) Macrophage Polarization Reidy, Paul T; McKenzie, Alec I; Fry, Christopher S; LaStayo, Paul C; Drummond, Micah J 109. Resistance Exercise Training-Induced Muscle Hypertrophy is Partly Modulated by Basal Post-Absorptive Muscle Protein Turnover Reidy, Paul T; Borack, Michael S; Markofski, Melissa M; Dickinson, Jared M; Fry Christopher S; Deer, Rachel R; Husaini, Syed H; Volpi, Elena; Rasmussen, Blake B 110. Increased HSP72 Expression is Required for Exercise-Induced Protection Against Ventilator-Induced Mitochondrial Dysfunction in the Diaphragm Smuder, Ashley J; Morton, Aaron B; Hall, Stephanie E; Ahn, Bumsoo; Wiggs, Michael P; Wawrzyniak, Nicholas R; Powers, Scott K 111. No Effect of Simvastatin Treatment on Skeletal Muscle Mitochondrial Adaptations to Exercise Training in Mice Southern, WM; Nichenko, A; Shill, DD; Jenkins, NT; McCully, KK; Call, JA 112. Satellite Cell Specific Deletion of Matrix Metalloproteinase 13 Alters Satellite Cell Migration and Muscle Regeneration Spradlin, Ray; Smith, Lucas; Zhang, Boshi; Hammers, David; Morales, Jazmine; Matheny, Michael; Barton, Elisabeth

10113. Cachectic Mouse Skeletal Muscle Anabolic Response to Acute and Training Eccentric Contractions Hardee, Justin P; Gao, Song; Fix, Dennis K; VanderVeen, Brandon N; Hetzler, Kimbell L; Carson, James A Mitochondria and Redox Biology 113. Mitophagy Protects Against Statin-Induced Muscle Cell Death Ramesh, M; Hernandez, G; Lee, P; Islam, MJ; Gurney, M; Linton, PJ; Gottlieb, RA; Andres, AM 114. Somatostatin Analog Stimulates Mitochondrial Biogenesis in Mouse Skeletal Muscle Ben-Shlomo, Anat; Gottlieb, Roberta A; Andres, Allen M; Ding, Evelyn; Ramtin, Khalafi; Yamamoto, Masaaki; Melmed, Shlomo

115. Autophagy Plays an Essential Role in Mitochondrial Remodeling and Functional Regeneration in Skeletal Muscle Call, Jarrod A; Laker, Rhianna C; Zhang, Mei; Yan, Zhen

116. Improved Skeletal Muscle Redox State Increases Aged Skeletal Muscle Performance Campbell, Matthew D; Knowles, Gary; Beyer, Richard; Gaffrey, Matthew; Szeto, Hazel; Qian, Wei-Jun; Marcinek, David J

117. Modeling in vivo Conditions in vitro Reveals Mitochondrial Respiratory Sensitivity to ADP is Impaired Following Chronic Exercise in Human Skeletal Muscle Hughes, MC; Ydfors, M; Laham, R; Schlattner, U; Norrbom, J; Perry, CGR 118. Age-Associated Changes in Oxidative Status Affect Exercise Redox Signaling Kramer, Philip A; Campbell, Matthew D; Marcinek, David J 119. Perioperative Hemidiaphragm Electrical Stimulation Reduces Oxidative Stress and Increases Autophagy Levels in Older Adults Mankowski, Robert T; Ahmed, Mustafa; Beaver, Thomas; Han, Chul; Hess, Phillip; Martin, Tomas; Someya, Shinichi; Leeuwenburgh, Christiaan; Martin, Anatole D

120. Autophagy Response Plays an Important Role in Muscle Regeneration Nichenko, AS; Southern, WM; Call, JA Muscle Metabolism 121. A Novel Small Molecule Links Triglyceride Accumulation with MondoA Signaling and Insulin Sensitivity in Muscle Ahn, Byungyong; Soundarapandian, Mangala; Sessions, Hampton; Brooks, Jeanne; Roth, Greg; Wang, Miao; Han, Xianlin; Vega, Rick B; Kelly, Daniel P

122. Defining Mechanisms for Altered Skeletal Muscle Function in the Absence of Xin; a Possible Role of Dysfunctional Mitochondria? Al-Sajee, Dhuha; Hughes, Meghan; Perry, Christopher; Provias, John; Mangan, Gary; Hawke, Thomas 123. Multi-Omic Analysis of Mammalian Hibernator Skeletal Muscle and Potential Mechanism of Metabolic Regulation Anderson, Kyle J; Andrews, Matthew T

124. Intramuscular Hyperoxia: A Potential Mechanism for the Slow Component of Oxygen Uptake Kinetics? Bartlett, Miles F; Kent, Jane A 125. Amino Acid Sensing in C2C12 Cells and Human Skeletal Muscle Borack, MS; Dickinson, JM; Reidy, PT; Husaini, SH; Markofski, MM; Deer, RR; Fry, CS; Jennings, K; Volpi, E; Rasmussen, BB 126. Late-onset Caloric Restriction Alters Skeletal Muscle Metabolism by Modulating Pyruvate Metabolism Chen, CN; Lin, SY; Liao, YH; Li, ZJ; Wong, MK 127. in vitro Alcohol Exposure Does Not Alter Myoblast Mitochondrial Function Duplanty, AA; Simon, L; Molina, PE 128. CaMKKα Regulates the Pentose Phosphate Pathway in Mouse Skeletal Muscle Ferey, Jeremie LA; Schmidt, Denise; Ferey, Joshua; Smith, Brandon; Means, Anthony R; Witczak, Carol A

129. Lipidomic Analyses of Human Skeletal Muscle Reveals LPCAT3 as a Potential Mediator of Insulin Resistance Ferrara, Patrick J; Paran, Christopher W; Song, Haowei; Turk, John; Funai, Katsuhiko 130. Oxidative Capacity in Human Skeletal Muscle in Vivo: A Meta-Analysis of the Effects of Old Age Fitzgerald, Liam F; Christie, Anita D; Kent, Jane A

131. Phosphatidylserine Decarboxylase Regulates Skeletal Muscle Respiration by its Action on Complex II Heden, Timothy D; Funai, Katsuhiko

132. Improved Contraction-Mediated Glucose Metabolism in Myotubes Derived from Roux-en-Y Gastric Bypass Patients Hinkley, J Matthew; Zou, Kai; Park, Sanghee; Turner, Kristen; Zheng, Donghai; Houmard, Joseph A

133. Independent AMPK and SIRT1 Signaling Regulate C2C12 Differentiation and Metabolic Adaptation Hsu, Chia George; Burkholder, Thomas J 134. Defective Autophagy Causes a Maladaptive Cardiac Phenotype to Exercise that Leads to Premature Death and FGF21-mediated Protection Against Obesity and Insulin Resistance Lira, Vitor A; Kronemberger, Ana; Call, Jarrod A; Caster, Hannah M; Pereira, Renata O; Laker, Rhianna C; Zhang, Mei ; Yan, Zhen

135. SLN Regulates Basal Metabolic Rate, Energy Expenditure and Whole Body Metabolism Maurya, Santosh Kumar; Periasamy, Muthu 136. Investigation of the “Nitric Oxide Receptor” Soluble Guanylate Cyclase 1 as a Regulator of Skeletal Muscle Fiber Type, Fatigue, Glycogen Storage and Insulin Sensitivity Moon, Younghye; Balke, Jordan E; Madorma, Derik; Siegel, Michael P; Brouckaert, Peter ; Buys, Emmanuel S; Marcinek, David J; Percival, Justin M

137. Effect of Pre-Exercise Nutrition on Human Skeletal Muscle UCP3 Expression Morales Marroquín, Flor Elisa; Forsse, Jeffrey; Andre, Thomas; McKinley-Barnard, Sarah; Hwang, Paul; Tinsley, Grant; Davis, John; Spillane, Mike; Grandjean, Peter; Willoughby, Darryn 138. Regulation of Cardiac Autophagic Flux In Vivo by the Ubiquitin Ligase Muscle Ring Finger-1 (MuRF1) Parry, Traci L; Willis, Monte S 139. Cardiac Muscle Ring Finger-1 (MuRF1) Regulates Fenofibrate’s Pleiotropic Effects in vivo Parry, Traci L; Willis, Monte S 140. Skeletal Muscle Protein Kinase C-theta Contributes to Diet-Induced Weight Gain Peck, Bailey; Black, Maya; Velez, Christine; Marino, Joseph S 141. Inhibition of Toll-Like Receptor 4 Does Not Prevent Palmitate-Induced Endoplasmic Reticulum Stress in Cultured Skeletal Muscle Cells Perry, Ben; Rahnert, Jill; Zheng, Bin; Price, S Russ

142. Mitochondrial Bioenergetics and Fibre Type Assessments in Microbiopsy vs Bergstrom Percutaneous Sampling of Human Skeletal Muscle Hughes, Meghan C; Ramos, Sofhia V; Turnbull, Patrick C; Nejatbakhsh, Ali; Baechler, Brittany L; Laham, Robert; Kane, Daniel A; Gurd, Brendon J; Quadrilatero, Joseph; Perry, Christopher GR 143. Fluvastatin Causes Hallmark Myopathic Characteristics at Rest, but Facilitates Repair of Both Healthy and Diabetic Skeletal Muscle Post-Injury Rebalka, IA; Raleigh, MJ; Rebalka, AN; Schertzer, JD; Hawke, TJ 144. A Genome-Wide Approach to Delineate Gene Targets Downstream of AMPK/PPARδ in Skeletal Muscle Smith, Emily Y; Horvath, Attila; Vega, Rick B; Nagy, Laszlo; Kelly, Daniel P 145. Single-cell Transcriptional Networks Indicate Two miRNAs as Regulators of Metabolism in Skeletal Muscle Fibers Chemello, Francesco; Cagnin, Stefano; Grespi, Francesca; Zulian, Alessandra; Cancellara, Pasqua; Hebert-Chatelain, Etienne; Martini, Paolo; Bean, Camilla; Laveder, Paolo; Bernardi, Paolo; Romualdi, Chiara; Reggiani, Carlo; Scorrano, Luca; Lanfranchi, Gerolamo

146. Mitochondrial Uncoupling-Independent Increase in Muscle Respiration Likely Mediates Anti-Obesogenic Phenotype of Phosphatidylethanolamine Methyltransferase Null Mice Verkerke, Anthony RP; Johnson, Jordan M; Lin, Chien-Te; Ryan, Terence E; Ferrara, Patrick J; Heden, Timothy D; Wentzler, Edward J; Neufer, P Darrell; Funai, Katsuhiko 147. Role of β2-adroneceptors on Skeletal Muscle Mitochondrial Function Voltarelli, Vanessa Azevedo; Fernandes, Larissa Golçalves; Jannig, Paulo Roberto; Brum, Patricia Chakur

148. Roux-en-Y Gastric Bypass Surgery Enhances Insulin-Mediated Glucose Oxidation and Mitochondria Biogenesis in Cultured Human Myotubes Zou, Kai; Hinkley, J Matthew; Park, Sanghee; Lynn, Michael; Zheng, Donghai; Dohm, G Lynis; Houmard, Joseph

Join us for the 2016 New Directions in Biology and Disease of Skeletal Muscle Conference in Orlando, FL! Wednesday. June 29- Saturday, July 2, 2016

The 2016 New Directions in Biology and Disease of Skeletal Muscle Conference will be held in Orlando, FL at the Renaissance Orlando at Sea World. The seventh biennial meeting is being organized by H. Lee Sweeney and Elizabeth McNally. The conference will highlight current developments in muscle biology, disease, and therapy with presentations by leading international researchers. Visit our website at: http://myology.institute.ufl.edu/new-directions/ Email: NewDirections@health.ufl.edu

http://www.cancercachexia2016.com