[ W O R L D C O N G R E S S O N O S T E O A R T H R I T I S ]

LIVERPOOLU N I T E D K I N G D O M

A P R I L 2 6 – 2 9

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2018.oarsi.org

FINALPROGRAM

PROMOTING CLINICAL AND BASIC RESEARCH I N O S T E O A R T H R I T I S

ACC LIVERPOOL CONGRESS CENTER

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WELCOME LETTER

DEAR COLLEAGUES,We are pleased to welcome you to the 2018 Osteoarthritis Research Society International (OARSI) World Congress in Liverpool, United Kingdom!

The annual OARSI Congress is a global forum for those involved in OA research and treatment from academia and industry; including basic scientists, clinical investigators, radiologists, rheumatologists, orthopedic surgeons, physicians in physical medicine and rehabilitation, allied health professionals and policy makers. In keeping with the multidisciplinary international membership of OARSI, this meeting will feature a worldwide selection of expert speakers from academia and industry.

Highlights of the 2018 program include plenary sessions on “The OARSI White Paper Explained,” “Non-Cartilaginous Soft Tissues in Osteoarthritis,” and “Growth Factors in OA: Opportunities for Intervention.” Our annual debate will be “Chondrocytes: Better Dead or Alive?” Breakfast workshops will allow attendees to meet and speak with experts in specific areas of basic or clinical science. Topics to be covered in these workshops include “Recent lessons from OA Imaging”, “Precision Medicine, Big Data and Machine Learning”, “In Vitro Models to Study Chondrocytes and Cartilage”, and “OA: Don’t Forget About the Foot” among others. Three pre-meeting workshops will be offered including “Lessons from Rare Diseases in Bone & Cartilage” jointly presented by the OARSI Young Investigators Committee and the Bone Research Society, “Update on Osteoarthritis Management Programs” presented by an international panel led by David Hunter of the University of Sydney, and the “KNEEMO Initial Training Network for Knee Osteoarthritis” which will present results from its 4-year investigation of knee OA biomechanics and epidemiology.

To increase the exposure of our younger members to the depth and breadth of research presented at OARSI and offer more networking opportunities, we will offer OARSI breakfast poster tours introduced last year. OARSI 2018 is also a great opportunity for young investigators to receive mentorship through the Meet the Professor session, to discuss their ideas, hopes and ambitions with leaders in diverse fields of research.

We are so thrilled you have chosen to attend this meeting and provide yourself the opportunity to join a global network of individuals from a broad range of disciplines, all working toward a better understanding of OA with the goal to prevent, treat or cure the disease. We hope you enjoy your experience at the 2018 OARSI World Congress!

Jeffrey Katz, MD, MS OARSI President

Carla Scanzello, MD PhD Congress Chair

Tuhina Neogi, MD PhD Abstract Chair

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EX-OFFICIO MEMBERSEditor-in-Chief Joel A. Block, MD Rush University Medical Center

Young Investigator Chair Katherine Boyer, PhD University of Massachusetts-Amherst

OARSI BOARD OF DIRECTORSPresident Jeffrey Katz, MD, MS Brigham and Woman’s Hospital

President-Elect Ali Mobasheri, BSc ARCS (Hons), MSc, DPhil (Oxon) University of Surrey

Secretary Kim Bennell, PhD, PT University of Melbourne

Treasurer Martin Englund, MD, PhD Lund University

Past President John Loughlin, PhD Newcastle University

George Bou-Gharios, BSc (Hons), PhD United KingdomRobin Christensen, BSc, MSc, PhD DenmarkDanny Chan, BSc (Hon); MSc, PhD Hong KongFlavia Ciccutini, MSc, PhD AustraliaCosimo DeBari, MD PhD FRCP, MRC Fellow, Hon Consultant Rheumatologist United KingdomCarolyn Emery, PhD, MSc, BScPT CanadaJerome Guicheux, PhD FranceIda Haugen, MD, PhD Norway

Marius Henriksen, PT, PhD DenmarkMorgan Jones, MD United States of AmericaJin Hong Kim, PhD KoreaThomas Link, MD, PhD United States of AmericaIngrid Meulenbelt, PhD the NetherlandsAli Mobasheri, BSc ARCS (Hons), MSc, DPhil (Oxon) United KingdomRachel Miller, PhD United States of AmericaRegis O’Keefe, MD, PhD United States of America

2018 OARSI WORLD CONGRESS PROGRAM PLANNING COMMITTEECarla Scanzello, MD, PhD Corporal Michael J. Crescenz VA Medical Center Philadelphia, PA, USA Program Chair

Tuhina Neogi, MD, PhD, FRCPC Boston University Boston, MA, USA Abstract Chair

OARSI CONGRESS STAFFDiann Stern, MS, CAE Executive Director dstern@oarsi.org

Anthony Celenza, CMP Director of Meetings acelenza@oarsi.org

Victoria Converse Associate Meeting Manager vconverse@oarsi.org

Dana Groves Industry Relations Manager dgroves@oarsi.org

Priscilla Lugo Membership Coordinator prodriguez@oarsi.org

GENERAL CONTACT INFO1120 Route 73 South • Suite 200 Mt. Laurel, NJ 08054 Phone: 856-439-0500 Fax: 856-439-0525 oarsi@oarsi.org

MEMBERS AT LARGEAileen Davis, PhD Krembil Research Institute

Changhai Ding, MD, PhD Southern Medical University

Jerome Guicheux, PhD INSERM

Gun-Il Im, MD, PhD Seoul National University Hospital

Muneaki Ishijima, MD, PhD Juntendo University

Rita Kandel, MD Mt. Sinai Hospital

Margreet G. Kloppenburg, MD, PhD Leiden University Medical Center

Peter van der Kraan, PhD Radboud University

Jianhao Lin, MD Peking University Hospital

Christopher Little, PhD Kolling Institute

Anne-Marie Malfait, MD, PhD Rush University Medical School

Stephen P. Messier, PhD Wake Forest University

Eeva Moilanen, MD University of Tampere Med Center

Tuhina Neogi, MD, PhD, FRCPC Boston University

Michael Nevitt, PhD, MPH University of California, San Francisco

Tonia Vincent, MD, PhD Kennedy Institute of Rheumatology

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GENERAL INFORMATIONAll events will take place at ACC Congress Center in Liverpool, United Kingdom from April 26 – 29, 2018.

REGISTRATION HOURSThe registration desk will be open during the following hours: (Hours are subject to change)

Thursday, April 26 7:00 AM – 7:00 PM Friday, April 27 7:00 AM – 6:00 PM Saturday, April 28 7:00 AM – 6:00 PM Sunday, April 29 7:00 AM – 12:00 PM

TICKETED EVENTSBREAKFAST WORKSHOPSTwo concurrent breakfast workshops will take place Friday, Saturday and Sunday morning. These workshops are ticketed events and there is an additional registration fee to attend these workshops, and space is limited. Please see the registration desk for more information and availability.

BREAKFAST POSTER TOURSFour concurrent breakfast poster tours will take place Friday and Saturday morning. These tours are ticketed events and there is an additional fee to attend the tour. Each tour only accommodates 20 people. Please see the registration desk for more information and availability.

CME ACCREDITATIONSATISFACTORY COMPLETIONLearners must complete an evaluation to receive a certificate of completion. Your chosen sessions must be attended in their entirety. Partial credit of individual sessions is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your board requirement.

PHYSICIANSIn support of improving patient care, this activity has been planned and implemented by Amedco LLC and the Osteoarthritis Research Society International. Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Credit Designation Statement – Amedco LLC designates this live activity for a maximum of 26.50 AMA PRA Category 1 Credits™. Physicians should claim only the creditcommensurate with the extent of their participation in the activity.

INTERNATIONAL CME ACCREDITATIONThe American Medical Association has determined that physicians not licensed in the US who participate in this CME activity are eligible for AMA PRA Category 1 Credits™.

ACCME / AMA PRA Category 1 Credits™ carry reciprocity with EACCME member countries and most international licensing bodies for physicians, with some exceptions. Physicians should check with their country/board for eligibility.

EVALUATIONS AND REGISTERING FOR CREDITS ONLINEUpon completion of the congress, physicians that wish to apply for CME credits can do so online. An e-mail will be sent to all registrants after the congress with a link to the site.

USE OF OARSI SCIENTIFIC PROGRAM CONTENTInformation presented during the 2018 World Congress is the property of OARSI and the presenter. Information may not be recorded, photographed, copied, photocopied, transferred to electronic format, reproduced, or distributed without the written permission of OARSI and the presenter. Any use of the program content, which includes, but is not limited to oral presentations, audiovisual materials used by speakers, and program handouts, without the written consent of OARSI is prohibited.

ABSTRACT EMBARGO POLICYAccepted abstracts are made available to the public on the OARSI website and are published in a special supplement of Osteoarthritis and Cartilage.

SPEAKER READY ROOMSPEAKER READY ROOM HOURS:Thursday, April 26 7:00 AM – 6:30 PM Friday, April 27 7:00 AM - 5:30 PM Saturday, April 28 7:00 AM – 5:30 PM Sunday, April 29 7:00 AM – 11:00 AM

The Speaker Ready Room is located in Room 10. The Speaker Ready Room is provided for presenters to prepare for their presentations and to ensure a seamless integration of a wide variety of audiovisual technologies in the various meeting rooms. By checking in at the Speaker Ready Room and following these simple guidelines, speakers will greatly contribute to the success of the meeting.

OARSI requests all presenters to use PowerPoint™ Presentations. All meeting rooms will have presentation computers and will be networked from a central computer located in the Speaker Ready Room. Presentations will be downloaded from the Speaker Ready

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Room and sent to the respective meeting room on a secured intranet circuit approximately 45 minutes prior to the start of each session. Presenters are encouraged and expected to bring their own CD-ROM or memory stick to the Speaker Ready Room where they will have the opportunity to review their presentations or make any last minute changes. All speakers must check into the Speaker Ready Room.

ABSTRACTS ON USBEach registrant will receive a USB with their registration packet that contains all of the abstracts presented at the congress.

EXHIBITSThe exhibits are an integral part of the complete education experience and will feature the latest in research products in the field of osteoarthritis. Please make time during the meeting to visit the exhibits during their open hours. They are located in Hall 2.

EXHIBIT HOURSThursday, April 26 7:30 PM – 9:00 PM Friday, April 27 10:00 AM – 5:00 PM Saturday, April 28 10:00 AM – 5:00 PM

On Thursday evening the opening reception will be held in the exhibit hall as well as all breaks. Coffee breaks sponsored by

POSTER SESSIONSSPONSORED BY:

The Posters Sessions are an important educational event of this meeting. We hope you support and attend these scientific presentations. Poster board numbers correspond with the poster numbers in this program book.

Posters may be viewed during the following times:

POSTER SESSION 1:Friday, April 27 12:00 PM – 1:00 PM

Odd Posters 12:00 PM – 12:30 PM

Even Posters 12:30 PM – 1:00 PM

POSTER SESSION 2:Friday, April 27 4:00 PM – 5:00 PM

Odd Posters 4:00 PM – 4:30 PM

Even Posters 4:30 PM – 5:00 PM

POSTER SESSION 3:Saturday, April 28 3:30 PM – 5:00 PM

Odd Posters 3:30 PM – 4:15 PM

Even Posters 4:15 PM – 5:00 PM

Any posters left on the boards after 5:00 PM on Saturday, April 28 will be removed and discarded.

POSTER TOURSOnce again, OARSI is offering Poster Tours for a fee of $25 each. Tours will begin at 7:30 AM and last until 8:30 AM and will feature a continental breakfast.

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SUPPORTThe Osteoarthritis Research Society International would like to thank the corporate supporters of OARSI Initiatives, Meetings and Congress.

It is with the support of industry that OARSI can continue its mission to prevent and treat osteoarthritis through the promotion and presentation of research, education and the world-wide dissemination of new knowledge.

OARSI SUPPORTERS

INDUSTRY PARTNERS

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OARSI BOARD AND COMMITTEE MEETINGS*all committee meetings will take place within the ACC Congress Center

WEDNESDAY, APRIL 25 TIME ROOMBoard of Directors Meeting 10:00 AM – 6:00 PM Pullman Hotel

THURSDAY, APRIL 26 TIME ROOMStrategic Alliance Meeting 12:00 PM – 1:30 PM Room 14Fiscal Committee Meeting 12:00 PM – 1:30 PM Room 13

FRIDAY, APRIL 28 TIME ROOMPublication Committee Meeting 7:30 AM – 8:30 AM Room 13Research & Training Committee Meeting 7:30 AM – 8:30 AM Room 14O & C Editorial Board Meeting 1:00 PM – 2:30 PM Room 12Young Investigator Committee Meeting 1:00 PM – 2:30 PM Room 13Treatment Guidelines Working Group 1:00 PM – 2:30 PM Room 14 (invitation only)

Corporate Council Meeting 4:00 PM – 5:00 PM Room 12Early OA Meeting 4:00 PM – 5:00 PM Room 13Elsevier EVISE Training Session 4:00 PM – 5:00 PM Room 4

SATURDAY, APRIL 29 TIME ROOMCross-Cohort Collaboration Meeting 7:30 AM – 8:30 AM Room 3Communications Committee Meeting 7:30 AM – 8:30 AM Room 14O & C Associate Editors Meeting 12:15 PM – 2:00 PM Room 12Ethics Committee Meeting 12:15 PM – 2:00 PM Room 142019 Program Planning Meeting 12:15 PM – 2:00 PM Room 13

SUNDAY, APRIL 30 TIME ROOMAsian Task Force 7:30 AM – 8:30 AM Room 14OA Phenotype Meeting 7:30 AM – 8:30 AM Room 13 (invitation only)

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EXHIBITOR DIRECTORY

AEQUUS RESEARCHBooth: B2

Aequus Research is an international marketing company that specialises in the healthcare industry.

AGINKO RESEARCH AGBooth: D3

AGINKO Research is a unique osteoarticular and inflammation focused preclinical and clinical research organization with an unrivaled reputation for conducting global studies and development programs of the highest integrity.

Our clients (pharmaceutical, biotechnology and medical device companies) rely on us to conduct world-class preclinical and clinical programs in the field of bone, cartilage, spine, inflammation, and pain. In these areas, in particular, we offer broad study experience and direct knowledge of study requirements, risk management, and best practice implementation.

ARTHRITIS RESEARCH UKBooth: D3

We invest in breakthrough treatments, the best information and vital support for everyone affected by arthritis. We believe that by harnessing the power of exceptional science we can overcome the pain, isolation and fatigue arthritis causes, making everyday life better for all people with arthritis in the UK.

ARTHO ABBooth: A6

Arthro is a healthcare company devoted to science and technology that wants to change the way the world views and treats chronic diseases. We transform healthcare and put it in your pocket while also making it more efficient.

BIOSEBBooth: C1

With more than 20 years of experience, Bioseb is designing equipment for Pre-Clinical Research, with a focus on Pain. With facilities in Europe & USA, our expertise is renown internationally: our innovative developments have been successfully engineered into reliable instruments. Our proven systems are used by the most advanced teams in prestigious Universities and laboratories all over the world.

HALYARD HEALTHBooth: D5

Halyard Health is a medical technology company focused on preventing infection, eliminating pain and speeding recovery. With innovations such as the COOLIEF* Cooled Radiofrequency Treatment, the ONLY minimally-invasive, thermal radiofrequency pain management system using water-cooled technology to safely deactivate pain-causing sensory nerves, clinically proven to provide up to 24 months of pain relief; improved physical functionality and reduced drug utilisation. Visit www.halyardhealth.co.uk

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LCA PHARMACEUTICALBooth: C3

First and Only Thermal RF Treatment FDA-Cleared for Relief from Osteoarthritis Knee Pain.

MEDI GMBH & CO., KGBooth: B4

Founded in Germany in 1951, medi GmbH & Co. KG in Germany is one of the world’s leading manufacturers of medical aids. Most of the products are made in Germany and are certificated with ISO 9010. For further information, please visit our website www.medi.de/en.

MERCKBooth: A1

Merck is a leading science and technology company in healthcare, life science and performance materials. Around 50,000 employees work to further develop technologies that improve and enhance life – from biopharmaceutical therapies to treat cancer or multiple sclerosis, cutting-edge systems for scientific research and production, to liquid crystals for smartphones and LCD televisions.

ÖSSURBooth: B1

As a global leader in non-invasive orthopaedics, we have nurtured an innovative mind-set, continuously pushing the boundaries to create the best products and services in the fields of Prosthetic, Osteoarthritis and Injury Solutions. Established in 1972 by leading Prosthetist Össur Kristinsson we are true advocates of “Life Without Limitations”. We work with individuals, clinicians and diverse communities around the world to support a better quality of life for millions of people.

OTTOBOCKBooth: D3

All over the world, the name Ottobock is a synonym for high-quality and technologically outstanding medical technology products and services. Ottobock develops med-tech products and fitting solutions for people with limited mobility in the areas of prosthetics, orthotics, human mobility (wheelchairs, rehab solutions) and medical care. The company’s international activities are coordinated from the head office in Duderstadt. Subsidiaries in more than 50 countries offer ’Made in Germany‘ quality all over the world, and are supported by more than 7,000 employees. Since its founding in 1919 Ottobock has been a family enterprise, and since 1988 Ottobock has supported the Paralympic Games with its technical know-how.

BEAGLE ORTHOPAEDICBooth: D3

Beagle Orthopaedic is a Blackburn based orthopaedic bracing company with an excellent reputation for both quality products and unsurpassed customer service. We set ourselves the challenge to provide superior Orthopaedic products manufactured in the UK.

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SAMUMEDBooth: A5

Samumed is a leader in medical research and development for tissue-level regeneration. With our platform’s origins in small molecule-based Wnt pathway modulation, we develop therapeutics to address a range of degenerative diseases, regenerative medicine and oncology. THUASNE

Booth: C4

Founded in France in 1847, The Thuasne Group is one of Europe’s oldest, largest and most respected orthopaedic companies, specialising in wearable medical devices. Thuasne has over 1,800, employees and subsidiary companies throughout Europe. The Action Reliever osteoarthritis knee brace is the latest in a long line of premium, innovative new products which Thuasne are famed for.

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2018 OARSI WORLD CONGRESS PROGRAMTHURSDAY, APRIL 268:00 AM – 12:30 PM Pre-Congress WorkshopsHall 1 B Lessons from Rare Diseases in Bone & Cartilage

Presented by OARSI Young Investigators & the Bone Research Society Miep Helfrich, PhD Nathanael Grey, BSc Juliette Hughes, MSc Lakshminarayan Ranganath, PhD Katarzyna Pirog, PhD Neil Thomas, BSc

Hall 1 C Advanced Biomechanics – From Evidence to New Technologies: Results from the KNEEMO Initial Training Network Wolfgang Wirth, PhD Dieter Rosenbaum, PhD Joost Dekker, PhD Jaap Harlaar, PhD Jim Woodburn, PhD, FFPM, RCPS(Glasg)

9:30 AM – 12:00 PM Update on Osteoarthritis Management ProgramsHall 1 A Krysia Dziedzic, PhD

Jillian Eyles, BAppSci(Physio) Melanie Holden, BSc (Hons) Physiotherapy, PhD Stephen Messier, PhD Philippa Nicolson, BPhty

12:00 PM – 1:30 PM Satellite Lunch SymposiaHall 2N/2F INVOSSA Has Potential as a Novel Disease Modifying Osteoarthritis (DMOAD) Therapy

P L E N A R Y S E S S I O N 1 – T H E O A R S I W H I T E P A P E R E X P L A I N E D

Moderated by: Marius Henriksen, PT, MSc, PhD and Elena Losina, PhD1:30 PM – 2:00 PM The Burden of OA: An Update on the OA Epidemiology, Morbidity and Co-MorbidityHall 1 Gillian Hawker, MD, MSc

2:00 PM – 2:30 PM OA is a Serious Disease Nigel Arden, MD, MSc

Sponsored by

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2:30 PM – 2:40 PM 1 ASSOCIATION OF HIP PAIN, WITH OR WITHOUT OSTEOARTHRITIS, ON EXCESS MORTALITY R. J. Cleveland, C. Alvarez, T. A. Schwartz, J. B. Renner, J. M. Jordan, A. E. Nelson, L. F. Callahan; UNC Thurston Arthritis Res. Ctr., Chapel Hill, NC

2:40 PM – 2:50 PM 2 CAUSE-SPECIFIC MORTALITY IN KNEE, HIP AND HAND OSTEOARTHRITIS A. Turkiewicz, A. A. Kiadaliri, M. Englund; Lund Univ., Clinical Sci. Lund, Orthopedics, Clinical Epidemiology Unit, Lund, Sweden

2:50 PM – 3:00 PM 3 THE DIFFERENTIAL INFLUENCE OF HIGH LEVELS OF PHYSICAL ACTIVITY ON KNEE OA IN OVERWEIGHT AND OBESE MEN AND WOMEN H. Soutakbar1, S. E. Lamb1, B. E. Scammell2, L. Hodgson2, K. L. Edwards2, A. J. Silman1; 1Univ. of Oxford, Oxford, United Kingdom, 2Univ. of Nottingham, Nottingham, United Kingdom

3:00 PM – 3:30 PM BREAK

P L E N A R Y S E S S I O N 2 – H I G H E S T R A T E D A B S T R A C T S B Y Y O U N G I N V E S T I G A T O R S

Moderated by: Katherine Boyer, PhD and Martijn Van den Bosch, PhD

3:30 PM – 3:40 PM 4Hall 1 EFFECTS OF DIETARY SATURATED FATTY ACID CONSUMPTION ON CARTILAGE HEALTH AND

TRAUMA-INDUCED OSTEOARTHRITIS IN RATS Prasadam, Sr., Y. Xiao, V; Inst. of Hlth. and bioMed. Innovation, Queensland Univeristy of Technology, Queensland, Australia

3:40 PM – 3:50 PM 5 IDENTIFICATION OF A CHONDROCYTE-SPECIFIC INDIAN HEDGEHOG ENHANCER AND SOX9-MEDIATED MECHANISMS OF THE ENHANCER ACTIVATION A. Yamakawa, H. Hojo, U. Chung, S. Ohba; Div. of Clinical Biotechnology, Ctr. for Disease Biology and Integrative Med., Faculty of Med., The Univ. of Tokyo, Tokyo, Japan

3:50 PM – 4:00 PM 6 DYSREGULATION OF THE NADASE CD38 IMPAIRS ARTICULAR CHONDROCYTE HOMEOSTASIS R. Liu-Bryan1, L-Y. Chen2; 1VASDHS/UCSD, San Diego, CA, 2VASDHS, San Diego, CA

4:00 PM – 4:10 PM 7 IDENTIFICATION OF NOVEL METHYLATION QUANTITATIVE TRAIT LOCI (mQTLS) AND FUNCTIONAL CHARACTERIZATION USING CRISPR/Cas9 AND GENE EXPRESSION ANALYSIS PRIORITIZES PLEC AS AN OA RISK GENE S. J. Rice, A. K. Sorial, G. Aubourg, C. Shepherd, M. Tselepi, D. Almarza, A. J. Skelton, D. Deehan, L. N. Reynard, J. Loughlin; Newcastle Univ., Newcastle upon Tyne, United Kingdom

4:10 PM – 4:20 PM 8 EARLY SYNOVIAL B-CELL INFILTRATION AS A CANDIDATE MECHANISM OF PATHOGENESIS IN THE OA OF OBESITY E. M. Schott, J. A. Lillis, C. W. Farnsworth, D. Villani, J. P. Ketz, J. M. Ashton, S. R. Gill, M. J. Zuscik, R. A. Mooney; Univ. of Rochester, Rochester, NY

Sponsored by

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4:20 PM – 4:30 PM 9 REASONS WHY OSTEOARTHRITIS PREDICTS MORTALITY: PATH ANALYSIS WITHIN A COX PROPORTIONAL HAZARDS MODEL S. Parmar1, D. Smith2, R. Wilkie1; 1Keele Univ., Newcastle-under-Lyme, United Kingdom, 2Manchester Metropolitan Univ., Manchester, United Kingdom

4:30 PM – 4:40 PM 10 MAPPING MESENCHYMAL STROMAL CELL LINEAGES DURING TISSUE REMODELLING IN A MOUSE MODEL OF OSTEOARTHRITIS K. Kania, A. J. Roelofs, H. Wang, C. De Bari; Arthritis and Regenerative Med. Lab., Inst. of Med. Sci., Univ. of Aberdeen, Aberdeen, United Kingdom

4:40 PM – 4:50 PM 11 PERIPHERAL BRAIN DERIVED NEUROTROPHIC FACTOR CONTRIBUTES TO CHRONIC JOINT PAIN IN TWO ANIMAL MODELS OF OSTEOARTHRITIS P. R. Gowler1,2, D. A. Walsh3,2, V. Chapman1,2; 1Sch. of Life Sci., Univ. of Nottingham, Nottingham, United Kingdom, 2Arthritis Res. UK Pain Ctr., Nottingham, United Kingdom, 3Sch. of Med., Univ. of Nottingham, Nottingham, United Kingdom

4:50 PM – 5:00 PM 12 MESENCHYMAL STEM CELL SECRETOME REDUCES PAIN AND SUBCHONDRAL BONE ALTERATIONS IN A MOUSE OSTEOARTHRITIS MODEL. S. Khatab, G. J. van Osch, N. Kops, Y. M. Bastiaansen-Jenniskens, P. Bos, J. A. Verhaar, M. R. Bernsen, G. M. van Buul; Erasmus MC, Rotterdam, Netherlands

5:00 PM – 5:15 PM Recognition of Young Investigators5:15 PM – 5:45 PM BREAK

O P E N I N G C E R E M O N Y & A W A R D P R E S E N T A T I O N S

Moderated by: Jeffrey Katz, MD, MSc and Ali Mobasheri, BSc, ARCS, MSc, Dphil5:45 PM – 6:10 PM Presidential Address and AwardsHall 1

6:10 PM – 6:20 PM Recognition of Lifetime Achievement Award Winner Mary Goldring, PhD

6:20 PM – 6:40 PM Recognition of Basic Science Award Winner James Martin, PhD (award accepted by Joseph Buckwalter, MD)

6:40 PM – 7:00 PM Recognition of Clinical Science Award Winner Ali Guermazi, MD, PhD

P L E N A R Y S E S S I O N 3 – K E Y N O T E A D D R E S S

Moderated by: Carla Scanzello, MD, PhD and Jos Runhaar, PhD7:00 PM – 7:30 PM Motivating Healthy Behavior in the Modern EraHall 1 David Asch, MD

7:30 PM – 9:00 PM Opening Reception with ExhibitorsHall 2

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FRIDAY, APRIL 277:30 AM – 8:30 AM Breakfast Workshop ARoom 4 Imaging and Insights in Hand OA Philip Conaghan, MD, PhD, FRACP, FRCP

Room 12 Breakfast Workshop B Biomechanical & Biochemical Implications of Obesity in OA Tim Griffin, PhD

Hall 2 Poster Tour 1 – Osteoarthritis Therapies Poster Tour 2 – Bone & Cartilage Poster Tour 3 – Imaging & Biomarkers Poster Tour 4 - Biomechanics

C O N C U R R E N T S E S S I O N 1 – C L I N I C A L B I O M E C H A N I C S

Moderated by: Kerry Costello, BSE, MSc and Steve Messier, PhD8:45 AM – 9:15 AM Neuromuscular Compromise in OA: More than Disuse Atrophy?Hall 1 Najia Shakoor, MD

9:15 AM – 9:25 AM 13 A RANDOMIZED CONTROLLED TRIAL INVESTIGATING CLINICAL AND BIOMECHANICAL CHANGES FOLLOWING TOE-OUT GAIT MODIFICATION FOR KNEE OSTEOARTHRITIS M. A. Hunt1, J. M. Charlton1, N. M. Krowchuk1, C. T. Tse1, G. L. Hatfield2; 1Univ. of British Columbia, Vancouver, BC, Canada, 2Univ. of The Fraser Valley, Chilliwack, BC, Canada

9:25 AM – 9:35 AM 14 THE EFFICACY OF LATERAL WEDGE INSOLES FOR PAINFUL MEDIAL KNEE OSTEOARTHRITIS AFTER PATIENT SCREENING: A RANDOMISED TRIAL D. T. Felson1,2, S. C. Carter2,3, A. Liu4, M. J. Parkes2,3, M. J. Callaghan5,3, R. K. Jones4,3; 1Boston Univ. Sch. of Med., Boston, MA, 2The Univ. of Manchester, Manchester, United Kingdom, 3Manchester Academic Hlth.Sci. Ctr., Manchester, United Kingdom, 4Univ. of Salford, Salford, United Kingdom, 5Manchester Metropolitan Univ., Manchester, United Kingdom

9:35 AM – 9:45 AM 15 ANALYSIS OF PROTEINS IN THE SYNOVIAL FLUID DURING JOINT DISTRACTION: UNRAVELLING MECHANO-SENSITIVE PATHWAYS THAT DRIVE INTRINSIC CARTILAGE REPAIR? F. E. Watt1, B. Hamid1, C. Garriga1, A. Judge1, R. Hrusecka1, R. Custers2, F. Lafeber2, S. Mastbergen2, T. L. Vincent1; 1Univ. of Oxford, Oxford, United Kingdom, 2Univ. Med. Ctr., Utrecht, Utrecht, Netherlands

9:45 AM – 9:55 AM 16 RELATION OF STEP RATE TO WORSENING OF PATELLOFEMORAL AND TIBIOFEMORAL JOINT CARTILAGE DAMAGE IN WOMEN AND MEN - THE MOST STUDY H. F. Hart1, K. D. Gross2, K. M. Crossley1, C. J. Barton1, D. Felson3, A. Guermazi3, F. Roemer3,4, B. Lewis5, N. Segal6,7, M. Nevitt8, J. J. Stefanik9; 1La Trobe Univ., Bundoora, Australia, 2MGH Inst. of Hlth.Professions, Boston, MA, 3Boston Univ., Boston, MA, 4Univ. of Erlangen-Nuremberg, Erlangen, Germany, 5Univerity of Alabama at Birmingham, Birmingham, AL, 6Univ. of Kansas Med. Ctr., Kansas City, KS, 7Univ. of Iowa, Iowa City, IA, 8Univ. of California San Francisco, San Francisco, CA, 9Univ. of Delaware, Newark, DE

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9:55 AM – 10:05 AM 17 INCREASE IN PATELLOFEMORAL LOADING IS NOT ASSOCIATED WITH WORSENING SYMPTOMS OR STRUCTURE: SECONDARY ANALYSIS FROM THE IDEA TRIAL D. Kumar1, M. P. LaValley2, D. P. Beavers3, A. Guermazi4, F. Eckstein5, D. J. Hunter6, S. P. Messier7; 1Boston Univ., Boston, MA, 2Boston Univ. Sch. of Publ. Hlth., Boston, MA, 3Wake Forest Sch. of Med., Winston-Salem, NC, 4Boston Univ. Sch. of Med., Boston, MA, 5Paracelsus Med. Univ., Salzburg, Austria, 6Univ. of Sydney, Sydney, Australia, 7Wake Forest Univ., Winston-Salem, NC

10:05 AM – 10:15 AM 18 THE ASSOCIATION BETWEEN KNEE JOINT MUSCLE ACTIVATION AND KNEE JOINT MOMENT PATTERNS DURING WALKING IN MODERATE MEDIAL COMPARTMENT KNEE OSTEOARTHRITIS: IMPLICATIONS FOR INTERVENTION. C. L. Hubley-Kozey1, K. E. Costello1, G. L. Hatfield2, D. M. Ikeda1, W. D. Stanish1, J. L. Astephen Wilson1; 1Dalhousie Univ., Halifax, NS, Canada, 2Univ. of the Fraser Valley, Chilliwack, BC, Canada

C O N C U R R E N T S E S S I O N 2 – U P D A T E O N A U T O P H A G Y

Moderated by: Jin-Hong Kim, PhD and Mohit Kapoor, PhD8:45 AM – 9:15 AM Role of Autophagy in the Pathogenesis of Skeletal DiseasesRoom 3 Carmine Settembre, PhD

9:15 AM – 9:25 AM 19 TARGETING GLYCOGEN SYNTHASE KINASE 3 SIGNALING IN CARTILAGE BIOLOGY: RNA-SEQ BASED TRANSCRIPTOME PROFILING S. K. Bali, L. Solomon, D. Bryce, F. Beier; Univ. of Western Ontario, London, ON, Canada

9:25 AM – 9:35 AM 20 INVOLVEMENT OF THE ANTI-AGING PROTEIN KLOTHO IN CHONDROCYTE AUTOPHAGY AND APOPTOSIS DURING OSTEOARTHRITIS E. Le Tilly, Jr.1, T. Ong, Jr.1, J. Abadie, Sr.2, J. Guicheux, Sr.1,3, L. Beck, Sr.1, C. Vinatier, Sr.1; 1INSERM UMR 1229 - RMeS, Regenerative Med. and Skeleton, STEP Team, Univ. of Nantes, UFR Odontology, Nantes, France, 2Animal cancers as Models fro research in comparative Oncology, AMaROC, ONIRIS, Nantes, France, 3CHU NAntes, PHU4 OTONN, Nantes, France

9:35 AM – 9:45 AM 21 ANP32A REGULATES ATM EXPRESSION AND PREVENTS OXIDATIVE STRESS IN CARTILAGE, BRAIN AND BONE F. M. CORNELIS1, S. MONTEAGUDO1, W. DEN HOLLANDER2, L. A. GUNS1, L. STORMS1, T. PEETERS1, I. MEULENBELT2, R. J. LORIES1; 1KU LEUVEN, LEUVEN, Belgium, 2LUMC, LEIDEN, Netherlands

9:45 AM – 9:55 AM 22 FUNCTIONAL COOPERATION OF GALECTIN-8 WITH GALECTIN-1 AND -3 IN TRIGGERING DISEASE MARKERS OF HUMAN OSTEOARTHRITIS S. Toegel1, D. Weinmann2, M. Kenn1, W. Schreiner1, S. Walzer1, H-J. Gabius3, R. Windhager1; 1Med. Univ. of Vienna, Vienna, Austria, 2Medcial Univ. of Vienna, Vienna, Austria, 3Ludwig Maximilians Univ., Munich, Germany

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9:55 AM – 10:05 AM 23 INHIBITION OF LRP1 SHEDDING REVERSES CARTILAGE DEGRADATION IN OSTEOARTHRITIS K. Yamamoto1, C. Scavenius2, S. Santamaria3, K. A. Botkjaer4, J. Dudhia5, L. Troeberg6, Y. Itoh6, G. Murphy4, J. J. Enghild2, H. Nagase6; 1Inst. of Ageing and Chronic Disease, Univ. of Liverpool, Liverpool, United Kingdom, 2Dept. of Molecular Biology and Genetics, Aarhus Univ., Aarhus, Denmark, 3Ctr. for Haematology, Imperial Coll. London, London, United Kingdom, 4Cancer Res. UK Cambridge Inst., Univ. of Cambridge, Cambridge, United Kingdom, 5Dept. of Clinical Sci. and Services, Royal Vet. Coll., Herts, United Kingdom, 6Kennedy Inst. of Rheumatology, Univ. of Oxford, Oxford, United Kingdom

10:05 AM – 10:15AM 24 GENOMIC AND PROTEOMIC BIOMARKER SCREENING SHOWS AUTOPHAGY DEFECTS IN BLOOD AND CHONDROCYTES IN OSTEOARTHRITIC PATIENTS I. Lorenzo-Gomez1, N. Oreiro1,2, S. Relaño1, F. J. Blanco1, B. Carames1; 1INIBIC, A Coruña, Spain, 2CHUAC, A Coruña, Spain

10:15 AM – 10:45 AM BREAKHall 2

P L E N A R Y S E S S I O N 4 – N O N - C A R T I L A G I N O U S S O F T T I S S U E S I N O A :

T E N D O N S , L I G A M E N T S A N D S Y N O V I U M

Moderated by: George Bou-Gharious, BSc (Hons), PhD and Eithne Comerford, MVB, PhD, DipECVS, MRCVS10:45 AM – 11:00 AM MSC Lineages in Synovium and their Contribution to Osteoarthritis and Cartilage RepairHall 1 Anke Roelofs, MSc, PhD

11:00 AM – 11:15 AM Functional Consequences of Tendonitis in OA Peter Clegg, MA Vet, MB, PhD

11:15 AM – 11:30 AM Regulation of Musculoskeletal Integration and Coordinated Growth Ronen Schweitzer, PhD

11:30 AM – 11:40 AM 25 INTEGRIN α10β1-SELECTED MESENCHYMAL STEM CELLS MITIGATE PROGRESSION OF POSTTRAUMATIC OSTEOARTHRITIS IN AN EQUINE ARTICULAR IMPACT MODEL M. L. Delco1, J. F. Talts2, S. L. Pownder3, M. Koff3, E. Lundgren-Åkerlund2, L. A. Fortier1; 1Cornell Univ., Ithaca, NY, 2Xintela AB, Lund, Sweden, 3Hosp. for Special Surgery, New York, NY

11:40 AM – 11:50 AM 26 CHARACTERISTICS AND USEFULNESS OF SYNOVIAL FLUID-DERIVED STEM CELLS COMPARED WITH SYNOVIUM-DERIVED STEM CELLS M. Amemiya, K. Tsuji, I. Sekiya, T. Muneta, H. Koga; Tokyo Med. and Dental Univ., tokyo, Japan

11:50 AM – 12:00 PM 27 EXPERIMENTAL TENDINOPATHY TREATMENT WITH SM04755, A TOPICAL SMALL MOLECULE INHIBITOR OF THE WNT PATHWAY V. Deshmukh, T. Seo, B. Hofilena, L. Dellamary, Y. Yazici; Samumed, San Diego, CA

12:00 PM – 1:00 PM POSTER SESSION 1Hall 2

1:00 PM – 2:30 PM Satellite Lunch SymposiaHall 2N/F Unraveling Chronic Pain: From Definition to Modulation

1:00 PM – 2:30 PM LUNCH ON OWN

Sponsored by

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C O N C U R R E N T S E S S I O N 3 – O A C L I N I C A L T R I A L S A N D T R E A T M E N T

Moderated by: Natalie Collins, PhD, PT and Tuhina Neogi, MD, PhD, FRCPC2:30 PM – 3:00 PM The Efficacy ParadoxHall 1 Michael Doherty, MD, MA, FRCP, ILTM

3:00 PM – 3:10 PM 28 HIP ARTHROSCOPY COMPARED TO BEST CONSERVATIVE CARE FOR THE TREATMENT OF FEMOROACETABULAR IMPINGEMENT SYNDROME: A RANDOMISED CONTROLLED TRIAL (UK FASHIoN) D. R. Griffin1, E. J. Dickensen1, R. Hobson2, A. Realpe1, N. Parsons1, F. Achana1, J. Smith1, J. Griffin1, C. E. Hutchinson1, S. Petrou1, P. D. Wall1, J. L. Donovan3, N. E. Foster4; 1Univ. of Warwick, Coventry, United Kingdom, 2Univ. of Leicester, Leicester, United Kingdom, 3Univ. of Bristol and NIHR CLAHRC West, Bristol, United Kingdom, 4Keele Univ., Keele, United Kingdom

3:10 PM – 3:20 PM 29 SIX MONTHS’ TREATMENT WITH MIV-711, A NOVEL CATHEPSIN K INHIBITOR INDUCES OSTEOARTHRITIS STRUCTURE MODIFICATION: RESULTS FROM A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED PHASE IIA TRIAL P. G. Conaghan1, M. A. Bowes2, S. R. Kingsbury1, A. Brett2, G. Guillard2, K. Tunblad3, B. Rizoska3, T. Larsson3, Å. Holmgren3, A. Manninen3, K. Göhlin3, W. Heber4, P. Graham3, Å. Jansson3, C. Wadell3, R. Bethell3, J. Öhd3; 1Univ. of Leeds, Leeds, United Kingdom, 2Imorphics Ltd, Manchester, United Kingdom, 3Medivir, Huddinge, Sweden, 4PAREXEL, Baltimore, MD

3:20 PM – 3:30 PM 30 SYNTHETIC TRANSDERMAL CANNABIDIOL FOR THE TREATMENT OF KNEE PAIN DUE TO OSTEOARTHRITIS D. Hunter1, G. Oldfield2, N. Tich3, J. Messenheimer3, T. Sebree3; 1Royal North Shore Hosp. and Inst. of Bone and Joint Res., Sydney, Australia, 2Pendlebury Res., Adamstown, Australia, 3Zynerba Pharmaceuticals, Devon, PA

3:30 PM – 3:40 PM 31 ADAMTS-5 INHIBITION WITH THE POTENT AND HIGHLY SELECTIVE INHIBITOR GLPG1972 RESULTS IN STRONG DISEASE-MODIFYING OA DRUG EFFECTS IN THE RAT MENISCECTOMY MODEL P. Clement-Lacroix1, S. Meurisse1, L. Lepescheux1, D. Merciris1, M. Borgonovi1, C. Cottereaux1, P. Mollat1, F. Brebion1, R. Gosmini1, F. De Ceuninck2, I. Botez2, T. Christophe3, E. E. van der Aar3, N. Vandervoort3, R. Blanqué1, D. Comas1, P. Deprez1, D. Amantini1; 1Galapagos, SASU, Romainville, France, 2Inst. de Recherches Servier, Suresnes, France, 3Galapagos NV, Mechelen, Belgium

3:40 PM – 3:50 PM 32 EFFICACY AND SAFETY OF INTRA-ARTICULAR SPRIFERMIN IN SYMPTOMATIC RADIOGRAPHIC KNEE OSTEOARTHRITIS: PRE-SPECIFIED ANALYSIS OF 3-YEAR DATA FROM A 5-YEAR RANDOMIZED, PLACEBO-CONTROLLED, PHASE II STUDY M. Hochberg1, A. Guermazi2, H. Guehring3, A. Aydemir4, S. Wax4, P. Fleuranceau-Morel4, A. Reinstrup Bihlet5, I. Byrjalsen5, J. Ragnar Andersen5, F. Eckstein6; 1Univ. of Maryland Sch. of Med., Baltimore, MD, 2Boston Univ. Sch. of Med. and Boston Imaging Core Lab, Boston, MA, 3Merck KGaA, Darmstadt, Germany, 4EMD Serono, Billerica, MA, 5Nordic BioSci., Herlev, Denmark, 6Inst. of Anatomy, Paracelsus Med. Univ. Salzburg & Nuremberg, Salzburg, Austria

3:50 PM – 4:00 PM 33 ARE ALL SUGAR PILLS CREATED EQUAL? A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS R. R. Bannuru, M. C. Osani, E. E. Vaysbrot, T. E. McAlindon; Tufts Med. Ctr., Boston, MA

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C O N C U R R E N T S E S S I O N 4 – G E N E T I C S & E P I G E N E T I C S

Moderated by: Ingrid Meulenbelt, PhD and Louise Reynard, MA (Cantab), PhD2:30 PM – 3:00 PM Noncoding RNAs in OA PathogenesisRoom 3 Tim Welting, PhD

3:00 PM – 3:10 PM 34 IDENTIFICATION AND CHARACTERISATION OF LONG NON-CODING RNAS EXPRESSED AND DYSREGULATED IN KNEE AND HIP OSTEOARTHRITIC CARTILAGE M. J. Barter1, B. Ajekigbe1, K. Cheung1, A. J. Skelton1, Y. Xu1, D. Deehan1, I. M. Clark2, D. A. Young1; 1Newcastle Univ., Newcastle upon Tyne, United Kingdom, 2Univ. of East Anglia, Norwich, United Kingdom

3:10 PM – 3:20 PM 35 A GENETIC RISK SCORE APPROACH TO ASSESS THE RELATIONSHIP BETWEEN LIPIDS AND OSTEOARTHRITIS M. S. Yau1,2, X. Sun2, D. T. Felson2,3; 1Inst. for Aging Res., Hebrew SeniorLife, Boston, MA, 2Boston Univ. Sch. of Med., Boston, MA, 3Univ. of Manchester, Manchester, United Kingdom

3:20 PM – 3:30 PM 36 MICRORNA-34A: ROLE IN THE DEVELOPMENT OF OSTEOARTHRITIS DURING OBESITY. H. Endisha1,2, P. Datta1, A. Sharma1, S. Nakamura1, G. Tavallaee1,2, R. Gandhi1, M. Kapoor1,2; 1Krembil Res. Inst., Toronto, ON, Canada, 2Univ. of Toronto, Toronto, ON, Canada

3:30 PM – 3:40 PM 37 STRATIFICATION OF KNEE OSTEOARTHRITIS: TWO MAJOR PATIENT SUBGROUPS IDENTIFIED BY GENOME WIDE EXPRESSION ANALYSIS OF ARTICULAR CARTILAGE J. Soul1, S. Dunn1, S. Anand2, F. Serracino-Inglott3, J-M. Schwartz1, R. Boot-Handford1, T. Hardingham1; 1Univ. of Manchester, Manchester, United Kingdom, 2Stockport NHS Fndn. Trust, Stockport, United Kingdom, 3Central Manchester NHS Fndn. Trust, Manchester, United Kingdom

3:40 PM – 3:50 PM 38 CAUSAL EFFECTS FOR HIGHER BODY MASS INDEX, BUT NOT FOR TRIGLYCERIDE LEVELS OR GENETIC PREDISPOSITION TO TYPE 2 DIABETES, ON OSTEOARTHRITIS F. P. Hartwig1, J. Steinberg2, E. Zengini3, K. Hatzikotoulas2, L. Southam2, I. Tachmazidou2, J. Wilkinson3, G. Davey Smith4, E. Zeggini2; 1Federal Univ. of Pelotas, Pelotas, Brazil, 2Wellcome Trust Sanger Inst., Hinxton, United Kingdom, 3Univ. of Sheffield, Sheffield, United Kingdom, 4Univ. of Bristol, Bristol, United Kingdom

3:50 PM – 4:00 PM 39 GENETIC EXPLORATION OF OSTEOARTHRITIS ENDOPHENOTYPES IDENTIFIES NEW BIOLOGICAL PATHWAYS IN OSTEOARTHRITIS C. G. Boer, L. Broer, D. Schiphof, J. Runhaar, E. Oei, E. Waarsing, R. Agricola, S. Bierma-Zeinstra, A. G. Uitterlinden, J. B. Meurs; Erasmus Med. Ctr., Rotterdam, Netherlands

4:00 PM – 5:00 PM POSTER SESSION 2Hall 2

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C O N C U R R E N T S E S S I O N 5 – O A C A R T I L A G E & B O N E

Moderated by: Blandine Poulet, PhD and Geraldine McCarthy, MD, FRCPI5:00 PM – 5:30 PM Insights into OA Pathogenesis from Abnormal Mineralization ProcessesHall 1 Hervé Kempf, PhD

5:30 PM – 5:40 PM 40 IN VIVOPULSED SILAC LABELING REVEALS DISTINCTIVE, AGE-DEPENDENT, TURNOVER RATES OF COLLAGENS OF ARTICULAR CARTILAGE AND BONE Y. Ariosa-Morejon1, P. Charles2, S. Davis2, R. Fischer1, T. Vincent1; 1Kennedy Inst. of Rheumatology, Oxford, United Kingdom, 2Target Discovery Inst., Oxford, United Kingdom

5:40 PM – 5:50 PM 41 OSTEOARTHRITIS SEVERITY IN MICE WITH DELETIONS OF JNK1 AND JNK2: NO PROTECTION AFTER DMM SURGERY AND ENHANCEMENT OF AGE-RELATED OA WITH JNK2 DELETION R. Loeser1, K. Kelley1, L. Harper2, C. Carlson2; 1Univ. of North Carolina, Chapel Hill, NC, 2Univ. of Minnesota, St Paul, MN

5:50 PM – 6:00 PM 42 LYMPHOID ENHANCER BINDING FACTOR 1-MEDIATED MATRIX METALLOPROTEINASE 13 GENE EXPRESSION IS REPRESSED BY SIRT1 IN HUMAN CHONDROCYTES J. Elayyan1, E-J. Lee2, E. Reich1, C. A. Smith3, S. J. Kimber3, Y. Henrotin4, A. Mobasheri5, M. Dvir-Ginzberg1; 1Hebrew Univ. of Jerusalem, Jerusalem, Israel, 2Univ. of Ulsan Coll. of Med., Seol, Korea, Democratic People’s Republic of, 3Univ. of Manchester, Manchster, United Kingdom, 4Univ. of Li`ege, Liege, Belgium, 5Univ. of Surrey, Guildford, United Kingdom

6:00 PM – 6:10 PM 43 DIFFERENTIAL CARTILAGE TURNOVER ALONG THE HUMAN LOWER LIMB REVEALED BY PROTEIN DEAMIDATION M-F. Hsueh1,2, P. Onnerfjord3,4, M. P. Bolognesi1,5, M. E. Easley1,5, V. B. Kraus1,6; 1Duke Univ., Durham, NC, 2Duke Molecular Physiology Inst., Durham, NC, 3Lund Univ., Lund, Sweden, 4Dept. of Clinical Sci., Lund, Sweden, 5Dept. of Orthopaedic Surgery, Durham, NC, 6Div. of Rheumatology, Dept. of Med., Durham, NC

6:10 PM – 6:20 PM 44 A CHOLECYSTOKININ RECEPTOR ANTAGONIST INHIBITS THE OSTEOARTHRITIS FEATURES INDUCED BY GPR22 IN VITRO AND IN VIVO L. GUNS1, S. MONTEAGUDO1, D. CALEBIRO2, M. LOHSE2, R. LORIES1, F. CAILOTTO1; 1KU LEUVEN, LEUVEN, Belgium, 2Univ. of Würzburg, Würzburg, Germany

6:20 PM – 6:30 PM 45 KIF26B IS NECESSARY FOR OSTEOGENIC TRANSDIFFERENTIATION AND MINERALISATION IN AN IN VITRO MODEL OF HETEROTOPIC OSSIFICATION G. Pickering, J. Simpson, E. Kiss-Toth, M. Wilkinson; The Univ. of Sheffield, Sheffield, United Kingdom

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C O N C U R R E N T S E S S I O N 6 – O A O U T C O M E S R E S E A R C H

Moderated by: Soren Skou, PT, MSc, PhD and Anita Wluka, MBBS, FRACP, PhD5:00 PM – 5:30 PM The Patient Perspective: Is OA More Debilitating than RARoom 3 Theodore Pincus, MD

5:30 PM – 5:40 PM 46 “IT PROBABLY DOESN’T ALWAYS MAKE IT INTO THE TOP OF THE LIST, I’LL BE HONEST WITH YOU:” PRIMARY CARE PHYSICIANS EXPERIENCES WITH PRESCRIBING EXERCISE FOR KNEE OSTEOARTHRITIS M. B. Christiansen1, F. Webster2, J. Christian2, E. Waugh3, N. Gakhal4, L. King5, G. Hawker6, D. K. White1; 1Univ. of Delaware Dept.s of Physical Therapy and Biomechanics and Movement Sci., Newark, DE, 2Univ. of Toronto Dalla Lana Sch. of Publ. Hlth., Toronto, ON, Canada, 3Univ. of Toronto Women’s Coll. Res. Inst., Toronto, ON, 4Univ. of Toronto Women’s Coll. Res. Inst., Univ. of Toronto Div. of Rheumatology, Toronto, ON, Canada, 5Univ. of Toronto Dept. of Med., Toronto, ON, Canada, 6Univ. of Toronto Div. of Rheumatology, Univ. of Toronto Dept. of Med., Toronto, ON

5:40 PM – 5:50 PM 47 ACTIVE LIVING WITH OSTEOARTHRITIS IMPLEMENTATION OF EVIDENCE-BASED GUIDELINES AS FIRST-LINE TREATMENT FOR PATIENTS WITH KNEE AND HIP OSTEOARTHRITIS M. Risberg, C. Tryggestad, L. Nordsletten, L. Engebretsen, I. Holm; Div. of Orthopedic Surgery, Oslo Univ. Hosp., Oslo, Norway

5:50 PM – 6:00 PM 48 IMPLEMENTING INTERNATIONAL OSTEOARTHRITIS GUIDELINES IN AN INTEGRATED CARE MODEL - RESULTS FROM A CLUSTER RANDOMIZED CONTROLLED TRIAL N. Østerås1, T. Moseng1, L. van Bodegom-Vos2, K. Dziedzic3, I. Mdala4, B. Natvig4, J. Røtterud5, Ø. Andreassen1, U-B. Schjervheim6, J. Hansen1, T. Vlieland7, K. Hagen1; 1Diakonhjemmet Hosp., Oslo, Norway, 2Leiden Univ. Med. Ctr., Leiden, Netherlands, 3Keele Univ., Keele, United Kingdom, 4Univ. of Oslo, Oslo, Norway, 5Akershus Univ. Hosp., Lørenskog, Norway, 6Nes Municipality, Nes, Norway, 7Leiden Univ. Med. Ctr., Leiden, Norway

6:00 PM – 6:10 PM 49 A TOTAL KNEE ARTHROPLASTY CARE PATHWAY AT A HIGH-VOLUME HEALTH SYSTEM: EFFECTS ON LENGTH OF STAY, DISCHARGE DISPOSITION, 90 DAY COMPLICATIONS, AND COST J. Featherall1, D. P. Brigati2, A. Arney3, M. Faour2, D. Bokar4, W. Messner5, C. Higuera-Rueda2; 1NIH, Bethesda, MD, 2Dept. of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, 3Dept. of Finance, Cleveland Clinic, Cleveland, OH, 4Office of Patient Experience, Cleveland Clinic, Cleveland, OH, 5Deparment of Quantitative Hlth.Sci., Cleveland Clinic, Cleveland, OH

6:10 PM – 6:20 PM 50 CARE GIVING AND SOCIAL ENGAGEMENT IN ARTHRITIS: KEEPING A BALANCE E. M. Badley1, D. B. Millstone2, A. V. Perruccio3; 1Hlth.care & Outcomes Res., Krembil Res. Inst.; Univ. of Toronto, Toronto, ON, Canada, 2Hlth.care & Outcomes Res., Krembil Res. Inst., Toronto, ON, Canada, 3Hlth.care & Outcomes Res. and Arthritis Program, Krembil Res. Inst.; IHPME, Univ. of Toronto, Toronto, ON, Canada

6:20 PM – 6:30 PM 51 THE NATURAL HISTORY OF FLARE-UPS: A DAILY DIARY STUDY OF PATIENTS WITH, OR AT HIGH RISK OF, KNEE OSTEOARTHRITIS E. Parry, R. Ogollah, G. Peat; Keele Univ., Keele, United Kingdom

6:45 PM – 8:00 PM Meet the Professor Mentorship Session for Young Investigators followed by ReceptionRoom 2N

6:45 PM – 8:00 PM Chinese Abstract SessionRoom 4

Sponsored by

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SATURDAY, APRIL 287:30 AM – 8:30 AM Breakfast Workshop CRoom 4 In vitro Models to Study Chondrocytes, Cartilage and OA Miguel Otero, PhD

Rocky Tuan, PhD

Room 12 Breakfast Workshop D Precision Medicine, Big Data and Machine Learning in OA Roman Krawetz, PhD

Hall 2 Poster Tour 5 – Osteoarthritis Therapies Poster Tour 6 – Bone & Cartilage Poster Tour 7 – Imaging & Biomarkers Poster Tour 8 – Biomechanics

C O N C U R R E N T S E S S I O N 7 – R E G E N E R A T I O N A N D R E P A I R

Moderated by: Farshid Guilak, PhD and Elena Jones, PhD8:45 AM – 9:15 AM Regenerative Therapy for OA: Hope or HypeHall 1 Gerjo van Osch, PhD

9:15 AM – 9:25 AM 52 SOX-6, 9-TRANSFECTED ADIPOSE STEM CELLS TO TREAT OSTEOARTHRITIS IN A GOAT OSTEOARTHRITIS MODEL G-I. Im, J-Y. Ko; Dongguk Univ. Ilsan Hosp., Goyang, Korea, Republic of

9:25 AM – 9:35 AM 53 FIBROBLAST GROWTH FACTOR 2 PROMOTES REGENERATION OF CARTILAGE BY ATTRACTING MESENCHYMAL STEM CELLS TO THE SITE OF CARTILAGE INJURY. S. N. Khan1, H. Muhammad1, J. J. Scammahorn1, F. Dell’Accio2, T. L. Vincent1; 1The Kennedy Inst. of Rheumatology, Oxford, United Kingdom, 2Queen Mary, Univ. of London, London, United Kingdom

9:35 AM – 9:45 AM 54 PERFORMANCE OF NASAL CHONDROCYTES IN AN OSTEOARTHRITIC ENVIRONMENT L. Acevedo1, K. Pelttari1, P. Occhetta1, J. Geurts2, C. Manferdini3, G. Lisignoli3, M. Haug4, S. Feliciano1, I. Martin1, A. Barbero1; 1Dept. of Biomedicine, Univ. of Basel, Univ. Hosp. of Basel, Basel, Switzerland, 2Dept.s Spine Surgery and BioMed. Engineering, Univ. Hosp. Basel, Univ. of Basel, Basel, Switzerland, 3S.C. Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, Bologna, Italy, 4Dept. of Plastic, Reconstructive, Aesthetic, and Hand Surgery, Univ. Hosp. Basel, Basel, Switzerland

9:45 AM – 9:55 AM 55 INVESTIGATING THE ROLE OF IN VIVO CELL CYCLE ACTIVATION WITHIN MESENCHYMAL STEM CELLS IN THE REGENERATIVE POTENTIAL OF ARTICULAR CARTILAGE AFTER INJURY A. O. Masson1, T. M. Underhill2, W. B. Edwards1, R. J. Krawetz1; 1Univ. of Calgary, Calgary, AB, Canada, 2Univ. of British Columbia, Vancouver, BC, Canada

9:55 AM – 10:05 AM 56 TRANSFORMING GROWTH FACTOR BETA INDUCED, A NEW PLAYER IN THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELLS M. Ruiz, K. Toupet, G. Fonteneau, M. Maumus, C. Jorgensen, D. Noel; Inserm U1183, Montpellier, France

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10:05 AM – 10:15 AM 57 DEFINING THE PHENOTYPE OF THE HUMAN FETAL NOTOCHORDAL CELL: IMPLICATIONS FOR INTERVERTEBRAL DISC REGENERATION L. Ward, R. Rodrigues-Pinto, M. Humphreys, J. Hoyland, S. M. Richardson; The Univ. of Manchester, Manchester, United Kingdom

C O N C U R R E N T S E S S I O N 8 – O A B I O M A R K E R S

Moderated by: Virgina Kraus, MD, PhD and Erwin van Spil, MD, PhD8:45 AM – 9:15 AM Are We Getting Closer to Surrogate Markers for OA?Room 3 Morten Karsdal, MSc, PhD

9:15 AM – 9:25 AM 58 DISCOVERY OF AN AUTOANTIBODY PROFILE FOR THE EARLY DIAGNOSIS OF KNEE OSTEOARTHRITIS USING NAPPA: DATA FROM THE OSTEOARTHRITIS INITIATIVE. M. Camacho Encina1, V. Calamia1, F. Picchi Figueira1, J. Van Duine2, J. Qiu2, C. Ruiz Romero1, J. LaBaer2, F. Blanco1; 1INIBIC-CHUAC, A Coruña, Spain, 2Biodesign Inst., Tempe, AZ

9:25 AM – 9:35 AM 59 LIPIDOMIC PROFILING OF HUMAN SYNOVIAL FLUID: METABOLITES GENERATED BY THE SOLUBLE EPOXIDE HYDROLASE ARE ASSOCIATED WITH INCREASED RISK OF KNEE OSTEOARTHRITIS AND RADIOGRAPHIC PROGRESSION. A. M. Valdes1, S. Ravipati1, P. Poussinis1, C. Menni2, M. Mangino2, V. Chapman1, D. Barrett1, M. Doherty1; 1Univ. of Nottingham, Nottingham, United Kingdom, 2King’s Coll. London, London, United Kingdom

9:35 AM – 9:45 AM 60 ACOUSTIC EMISSIONS AND KINETIC INSTABILITY AS NEW CLINICAL BIOMARKERS TO NONINVASIVELY ASSESS KNEE OSTEOARTHRITIS A. Tiulpin1, J. Thevenot1, J. Hirvasniemi1, J. Niinimäki2,1, S. Saarakkala1,2; 1Univ. of Oulu, Oulu, Finland, 2Oulu Univ. Hosp., Oulu, Finland

9:45 AM – 9:55 AM 61 MALDI-MSI ANALYSIS REVEALED AN INCREMENT OF LIPID CANDIDATE BIOMARKERS IN OA SYNOVIUM B. Rocha1,2, B. Cillero-Pastor2, C. Ruiz-Romero1,3, R. Heeren2, F. Blanco1,4; 1Rheumatology Div., ProteoRed/ISCIII Proteomics Group, INIBIC - Hosp. Univ.rio de A Coruña, A Coruña, Spain, 2The Maastricht Multimodal Molecular Imaging Inst. (M4I), Div. of Imaging Mass Spectrometry, Maastricht Univ., Maastricht, Netherlands, 3CIBER-BBN Inst. de Salud Carlos III, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, 4RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain

9:55 AM – 10:05 AM 62 BIOMARKERS OF MACROPHAGE-ASSOCIATED INFLAMMATORY PATHWAYS ARE ASSOCIATED WITH OA SYMPTOMS AND RADIOGRAPHIC DISEASE J. L. Huebner, C. Haraden, Y-J. Li, V. B. Kraus; Duke Molecular Physiology Inst., Durham, NC

10:05 AM – 10:15 AM 63 IDENTIFICATION OF TISSUE-SPECIFIC BIOMARKERS IN KNEE OSTEOARTHRITIS SYNOVIAL FLUID: A PROTEOMIC APPROACH. U. Timur1, H. Jahr2, P. Emans1, L. van Rhijn1, M. Peffers3, T. Welting1; 1Maastricht Univ., Maastricht, Netherlands, 2RWTH Aachen, Aachen, Germany, 3Univ. of Liverpool, Liverpool, United Kingdom

10:15 AM – 10:45 AM BREAKHall 2

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P L E N A R Y S E S S I O N 5 – G R O W T H F A C T O R S I N O A :

O P P O R T U N I T I E S F O R I N T E R V E N T I O N ?

Moderated by: Cosimo deBari, MD, PhD, FRCP and Jerome Guicheux, PhD10:45 AM – 11:15 AM Heparan Sulfate Control of Growth Factor Activity in Joint TissuesHall 1 John Whitelock, PhD

11:15 AM – 11:45 AM Growth Factor Therapy for Osteoarthritis: Ready for “Prime Time”? David Hunter, PhD, FRACP

11:45 AM – 11:55 AM 64 NEW CHIMERIC PEPTIDES REGULATING IGF-1 SHOW SIGNIFICANT THERAPEUTICEFFECT ON ANTERIOR CRUCIATE LIGAMENT TRANSECTION RABBIT MODEL OFOSTEOARTHRITIS R. Paolini, R. Montjean, C. Vetu; Regulaxis, Romainville, France

11:55 AM – 12:05 PM 65 ARTICULAR CARTILAGE FROM OSTEOARTHRITIS PATIENTS SHOWS EXTRACELLULAR MATRIX REMODELING OVER THE COURSE OF TREATMENT WITH SPRIFERMIN (RECOMBINANANT HUMAN FIBROBLAST GROWTH FACTOR 18) D. Reker1, C. S. Thudium1, A. Sofie Siebuhr1, T. Gantzel2, C. Ladel3, M. Michaelis3, M. A. Karsdal1, A. Gigout3, A. C. Bay-Jensen1; 1Biomarkers and Res. Rheumatology, Nordic BioSci. A/S, Herlev, Denmark, 2Orthopedic Surgery Unit, Gentofte Hosp., Gentofte, Denmark, 3Osteoarthritis Res., Merck KGaA, Darmstadt, Germany

12:05 PM – 12:15 PM 66 INVOSSA, A FIRST-IN-CLASS OF CELL AND GENE THERAPY FOR OSTEOARTHRITIS TREATMENT: THE PHASE III TRIAL B. Lee; TissueGene, Inc., Rockville, MD

12:15 PM – 2:00 PM Satellite Lunch SymposiaHall 2N/F Advancing Disease Modification in Knee Osteoarthritis: Clinical Implications of Wnt Pathway Inhibition

12:15 PM – 2:00 PM LUNCH ON OWN12:15 PM – 2:00 PM Workshop for Young Investigators - Practical Advice for Power and Sample Size (Lunch Provided)Room 4 Jamie E. Collins PhD

Aleksandra Turkiewicz PhD Elena Losina, PhD

C O N C U R R E N T S E S S I O N 9 – “ I N F L A M M A G I N G ”

Moderated by: Jeroen Geurts, PhD and Richard Loeser, MD2:00 PM – 2:30 PM Senescent Cells as Inflammatory Targets in OAHall 1 Jennifer Elisseeff, PhD

2:30 PM – 2:40 PM 67 OXIDATIVE STRESS-INDUCED SULFENYLATION OF SIRT6 IS ASSOCIATED WITH ENHANCED NF-κB SIGNALING IN HUMAN CHONDROCYTES J. A. Collins1, B. O. Diekman1, M. T. DeFoor1, S. T. Wood1, J. A. Bolduc1, K. J. Nelson2, S. Chubinskaya3, L. B. Poole2, C. M. Furdui2, R. F. Loeser1; 1Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, 2Wake Forest Sch. of Med., Winston-Salem, NC, 3Rush Univ. Med. Ctr., Chicago, IL

Sponsored by

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2:40 PM – 2:50 PM 68 IMAGING LOW-GRADE INFLAMMATION IN POST-TRAUMATIC OSTEOARTHRITIS A. Ruiz1, A. Duarte1, M. Milne2, D. Bravo1, L. Luyt2, J. Raya1; 1NYU Sch. of Med., New York, NY, 2Univ. of Western Ontario, London, ON, Canada

2:50 PM – 3:00 PM 69 A ROLE FOR THE SNORNA U3 IN THE ALTERED TRANSLATIONAL CAPACITY OF AGEING AND OSTEOARTHRITIC CHONDROCYTES M. J. Peffers1, E. Ripmeester2, M. Caron2, M. Steinbusch2, P. Balaskas3, A. Cremers4, D. Surtel4, T. J. Welting2; 1Univ. of Liverpool, Neston, United Kingdom, 2Maastricht Univ. Med. Ctr., Maastricht, Netherlands, 3Univ. of Liverpool, Liverpool, United Kingdom, 4Maastricht Univ. Med. Ctr., Maastricht, United Kingdom

3:00 PM – 3:10 PM 70 ADIPOSE MESENCHYMAL STROMAL CELLS DETERMINE THE SWITCHING OF THE PRO-INFLAMMATORY PROFILE OF SYNOVIAL OSTEOARTHRITIC MACROPHAGES c. manferdini1, F. Paolella1, E. Gabusi1, L. Gambari2, G. Filardo3, S. Fleury-Cappellesso4, A. Barbero5, M. Murphy6, G. Lisignoli1; 1Lab. of Immunorheumatology and tissue regeneration, Rizzoli Orthopaedic Inst., Bologna, Italy, 2RAMSES Lab., Rizzoli Orthopaedic Inst., Bologna, Italy, 3NABI Lab., Rizzoli Orthopaedic Inst., Bologna, Italy, 4EFS-Pyrénéés-Méditerranéé, Toulouse, France, 5Dept. of Surgery and Biomedicine, Univ. Hosp., Basel, Switzerland, 6Regenerative Med. Inst., Galway, Ireland, Galway,, Ireland

3:10 PM – 3:20 PM 71 ENDOTHELIN RECEPTOR TYPE B BLOCKER ATTENUATES SEVERITY OF OSTEOARTHRITIS BY CLEARANCE OF SENESCENT CELLS M. Au1, Z. Liu2, C. Wen1; 1The Hong Kong Polytechnic Univ., Hong Kong, China, 2The Third Affiliated Hosp. of Sun Yat-Sen Univ., Guangzhou, China

3:20 PM – 3:30 PM 72 SENESCENCE ACCELERATED MICE AS A NEW MOUSE MODEL FOR SPONTANEOUS OSTEOARTHRITIS Y. Sanada1, S. Miyaki1, Y. Ikuta1,2, H. Ishitobi1, M. Shinohara3, K. Nagira2, M. Ishikawa1, T. Nakasa1, K. Matsubara1, M. K. Lotz2, N. Adachi1; 1Hiroshima Univ., Hiroshima, Japan, 2The Scripps Res. Inst., La Jolla, CA, 3Tokyo Med. and Dental Univ., Tokyo, Japan

C O N C U R R E N T S E S S I O N 1 0 – O A I M A G I N G

Moderated by: Ida Haugen, MD, PhD and Thomas Link, MD, PhD2:00 PM – 2:30 PM Advanced Imaging of Hip OsteoarthritisRoom 3 Sharmila Majumdar, PhD

2:30 PM – 2:40 PM 73 NEURALSEG: STATE-OF-THE-ART CARTILAGE SEGMENTATION USING DEEP LEARNING - ANALYSES OF DATA FROM THE OSTEOARTHRITIS INITIATIVE A. A. Gatti1,2; 1McMaster, Hamilton, ON, Canada, 2NeuralSeg Ltd., Hamilton, ON, Canada

2:40 PM – 2:50 PM 74 FLUORESCENCE OPTICAL IMAGING ENHANCEMENT IS ASSOCIATED WITH JOINT PAIN IN HAND OSTEOARTHRITIS Ø. Maugesten1, S. Ohrndorf2, S. V. Hestetun1, B. Slatkowsky-Christensen1, T. K. Kvien1, T. Uhlig1, I. K. Haugen1; 1Dept. of Rheumatology, Diakonhjemmet Hosp., Oslo, Norway, 2Dept. of Rheumatology and Clinical Immunology, Charité Univ.smedizin, Berlin, Germany

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2:50 PM – 3:00 PM 75 COMBINING FRACTAL- AND ENTROPY-BASED BONE TEXTURE ANALYSIS FOR THE PREDICTION OF OSTEOARTHRITIS: DATA FROM THE MULTICENTER OSTEOARTHRITIS STUDY (MOST) Z. Bertalan1, R. Ljuhar1, B. Norman1, D. Ljuhar2, A. Fahrleitner-Pammer3, H-P. Dimai3, S. Nehrer4; 1ImageBiopsy Lab, Vienna, Austria, 2Braincon Technologies, Vienna, Austria, 3Dept. of Internal Med., Div. of Endocrinology and Diabetology, Med. Univ. of Graz, Graz, Austria, 4Ctr. for Regenerative Med. & Orthopedics, Danube Univ., Krems, Austria

3:00 PM – 3:10 PM 76 T1ρ AND T2 OF ARTICULAR CARTILAGE AFTER ACL INJURY PREDICT PATIENT-REPORTED OUTCOMES AT 3 YEARS AFTER ACL RECONSTRUCTION K. Mamoto1,2, K. Xu1,2, T. Shimizu2, M. Tanaka2, V. Pedoia2, C. Ma2, X. Li1,2; 1Cleveland Clinic, Cleveland, OH, 2Univ. of California, San Francisco, San Francisco, CA

3:10 PM – 3:20 PM 77 WHEN THE ‘WHOLE’ IS MORE THAN A ‘SUM’ OF ITS PARTS: QUANTIFYING TOTAL BURDEN OF KNEE OA USING SEMI-QUANTITATIVE KNEE MRI ASSESSMENT J. E. Collins1, D. J. Hunter2, A. Guermazi3, F. W. Roemer4, J. N. Katz1, E. Losina1; 1Brigham and Women’s Hosp., Boston, MA, 2Univ. of Sydney, Sydney, Australia, 3Boston Univ. Sch. of Med., Boston, MA, 4Univ. of Erlangen-Nuremberg, Erlangen, Germany

3:20 PM – 3:30 PM 78 INTRA-ARTHROSCOPIC EVALUATION OF SCORING HIP OSTEOARTHRITIS WITH MRI (SHOMRI) J. Neumann1, A. L. Zhang2, M. A. Samaan1,3, B. J. Schwaiger1,4, T. Grace2, R. Souza1,3, T. M. Link1, S. Majumdar1; 1UCSF Dept. of Radiology & BioMed. Imaging, San Francisco, CA, 2UCSF Dept. of Orthopedic Surgery, San Francisco, CA, 3UCSF Dept. of Physical Therapy & Rehabilitation Sci., San Francisco, CA, 4Dept. of Diagnostic and Interventional Radiology, Technical Univ. of Munich, Munich, Germany

3:30 PM – 5:00 PM POSTER SESSION 3Hall 2

P L E N A R Y S E S S I O N 6 – D E B A T E

Moderated by: Francesco Dell’Accio, MD, PhD, FRCP and Anne Marie Malfait, MD, PhD5:00 PM – 6:00 PM Chondrocytes: Better Dead or Alive?Hall 1 DEAD: Matthew Warman, MD

ALIVE: Martin Lotz, MD

Special Interest Groups

6:15 PM – 7:45 PM Accelerated Approval for Subpart H – What does this mean for the OA Field

Virginia Kraus, MD, PhD Claudia Dollins, PhD RAC Anne-Christine Bay-Jensen, PhD, MSc Hans Guhering, MD Kent Kwoh, MD

6:15 PM – 7:45 PM Athletic Trainers Osteoarthritis ConsortiumRoom 4

6:15 PM – 7:45 PM Imaging Interest GroupRoom 12

Sponsored by

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SUNDAY, APRIL 297:30 AM – 8:30 AM Breakfast Workshop ERoom 4 OA: Don’t Forget About the Foot Douglas Gross, DPT, ScD

Breakfast Workshop FRoom 12 Targeted Genome and Epigenome Editing for OA Research and Therapy Farshid Guilak, PhD

C O N C U R R E N T S E S S I O N 1 1 – S E C O N D A R Y P R E V E N T I O N O F O A

Moderated by: Ewa Roos, PT, PhD and Carolyn Emery, PT, PhD8:45 AM – 9:15 AM Targeting Secondary Prevention for OA: Who is at Greatest Risk Following Joint injury?Hall 1 Jackie Whittaker, PT, PhD

9:15 AM – 9:25 AM 79 MOLECULAR AND STRUCTURAL BIOMARKERS OF LOCAL INFLAMMATION AT 2 YEARS AFTER ANTERIOR CRUCIATE LIGAMENT INJURY DO NOT ASSOCIATE WITH PATIENT REPORTED OUTCOMES AT 5 YEARS A. Struglics1, A. Turkiewicz2, S. Larsson1, L. S. Lohmander1, F. W. Roemer1,3, R. Frobell1, M. Englund2; 1Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Lund, Sweden, 2Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Clinical Epidemiology, Lund, Sweden, 3Boston Univ. Sch. of Med., Dept. of of Radiology, Quantitative Image Ctr., Boston, MA

9:25 AM – 9:35 AM 80 PATIENT-REPORTED OUTCOME 32 TO 37 YEARS FOLLOWING SURGICALLY TREATED OR NON-SURGICALLY TREATED ACUTE ANTERIOR CRUCIATE LIGAMENT INJURY S. R. Filbay1,2, C. Andersson3, C. Ardern2, H. Gauffin2, J. Kvist2,4; 1Univ. of Oxford, Oxford, United Kingdom, 2Linköping Univ., Linköping, Sweden, 3Linköping Hosp., Linköping, Sweden, 4Karolinska Inst.t, Stockholm, Sweden

9:35 AM – 9:45 AM 81 THE ASSOCIATION BETWEEN PHYSICAL ACTIVITY, INTRA-ARTICULAR KNEE INJURY AND KNEE INJURY AND OSTEOARTHRITIS SCORE: A MATCHED COHORT DESIGN C. M. Toomey1, J. L. Whittaker2,1, P. K. Doyle-Baker1, C. A. Emery1; 1Univ. of Calgary, Calgary, AB, Canada, 2Univ. of Alberta, Edmonton, AB, Canada

9:45 AM – 9:55 AM 82 LIMITING THE RISK OF OSTEOARTHRITIS AFTER ANTERIOR CRUCIATE LIGAMENT INJURY: ARE WE MISSING THE OPPORTUNITY TO INTERVENE? A. Davis1, R. Wong1, K. Steinhart1, J. Astephen Wilson2, L. Cruz3, D. Cudmore2, T. Dwyer4, L. Li5, P. MacDonald6, P. Marks7, L. Nimmon1, D. Ogilvie-Harris1, N. Urquart2, J. Chahal8; 1Krembil Res. Inst. Univ. Hlth.Network, Toronto, ON, Canada, 2Dalhousie Univ., Halifax, NS, Canada, 3Univ. of Toronto, Toronto, ON, Canada, 4Women’s Coll. Hosp., Toronto, ON, Canada, 5Arthritis Res. Ctr. of Canada, Vancouver, BC, Canada, 6Pan Am Sports Clinic and Univ. of Manitoba, Winnipeg, MB, Canada, 7Sunnybrook Hlth.Sci. Ctr., Toronto, ON, Canada, 8Univ. Hlth.Network, Toronto, ON, Canada

9:55 AM – 10:05 AM 83 GAIT MECHANICS AND TIBIOFEMORAL LOADING IN MEN OF THE ACL-SPORTS RANDOMIZED CONTROL TRIAL J. J. Capin, A. Khandha, R. Zarzycki, A. J. Arundale, M. L. Ziegler, K. Manal, T. S. Buchanan, L. Snyder-Mackler, L. Snyder-Mackler; Univ. of Delaware, Newark, DE

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10:05 AM – 10:15 AM 84 PEOPLE WITH SELF-REPORTED PRIOR KNEE INJURY REPRESENT A DISTINCT SUBGROUP IN KNEE OSTEOARTHRITIS: A CROSS-SECTIONAL STUDY OF 10 973 PARTICIPANTS FROM THE DANISH GLA:D® REGISTRY P. M. Holm1,2, E. M. Roos2, E. Boyle2, S. T. Skou1,2; 1Dept. of Physiotherapy and Occupational Therapy, Næstved- Slagelse- Ringsted Hosp., Region Zealand, Slagelse, Denmark, 2Dept. of Sports Sci. and Clinical Biomechanics, Univ. of Southern Denmark, Odense M, Denmark

C O N C U R R E N T S E S S I O N 1 2 – O A P A I N

Moderated by: Jason McDougall, BSc, PhD and Rachel Miller, PhD8:45 AM – 9:15 AM Pain Mechanisms in Osteoarthritis - Implications for TreatmentRoom 3 Anthony Dickenson, BSc, PhD, FmedSci

9:15 AM – 9:25 AM 85 INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE THERAPY PREVENTS AND DELAYS SURGICALLY-INDUCED OSTEOARTHRITIS IN SMALL AND LARGE ANIMAL MODELS M. W. Grol1, A. Nixon2, H. M. Lang2, M. Z. Ruan1, L. Begum2, B. Dawson1, S. Plutizki3, B. H. Lee1, K. Guse1,3; 1Baylor Coll. of Med., Houston, TX, 2Cornell Univ., Ithaca, NY, 3GeneQuine Biotherapeutics GmbH, Hamburg, Germany

9:25 AM – 9:35 AM 86 S100A9 MEDIATES ACUTE NOCICEPTIVE PAIN IN EXPERIMENTAL SYNOVITIS A. B. Blom, M. H. van den Bosch, E. J. Geven, E. N. Blaney Davidson, P. M. van der Kraan, P. L. van Lent; Radboud Univ. Med. center, Nijmegen, Netherlands

9:35 AM – 9:45 AM 87 A DECREASE IN MRI-DEFINED INFLAMMATION IS ASSOCIATED WITH A DECREASE IN PAIN IN PATIENTS WITH HAND OSTEOARTHRITIS S. van Beest, W. Damman, R. Liu, M. Kloppenburg; Leiden Univ. Med. Ctr., Leiden, Netherlands

9:45 AM – 9:55 AM 88 DESTABILIZATION OF THE MEDIAL MENISCUS CAUSES PROFOUND CHANGES IN THE NAV1.8 NOCICEPTIVE INNERVATION OF THE MURINE KNEE JOINT A. M. Obeidat1, R. J. Miller2, R. E. Miller1, A. Malfait1; 1Rush Univ. Med. center, Chicago, IL, 2Northwestern Univ. Feinberg Sch. of Med., Chicago, IL

9:55 AM – 10:05 AM 89 SENSITIZATION AND PAIN SEVERITY IN PATIENTS WITH HAND OSTEOARTHRITIS - DATA FROM THE NOR-HAND STUDY P. Steen Pettersen1, T. Neogi2, K. Magnusson1,3, H. B. Hammer1, T. K. Kvien1,4, T. Uhlig1, I. K. Haugen1; 1Dept. of Rheumatology, Diakonhjemmet Hosp., Oslo, Norway, 2Boston Univ., Sch. of Med., Boston, MA, 3Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden, 4Univ. of Oslo, The Med. Faculty, Inst. for Clinical Med., Oslo, Norway

10:05 AM – 10:15 AM 90 PSYCHOLOGICAL CHARACTERISTICS AND PAIN SENSITIZATION IN PEOPLE WITH SYMPTOMATIC AND MRI FEATURES OF PATELLOFEMORAL OSTEOARTHRITIS: THE MULTICENTER OSTEOARTHRITIS STUDY N. J. Collins1, T. Neogi2, B. Vicenzino1, A. Guermazi2, F. W. Roemer3, C. E. Lewis4, J. C. Torner5, M. C. Nevitt6, J. J. Stefanik7; 1The Univ. of Queensland, Brisbane, Australia, 2Boston Univ., Boston, MA, 3Univ. of Erlangan-Nuremburg, Erlangan, Germany, 4The Univ. of Alabama at Birmingham, Birmingham, AL, 5Univ. of Iowa, Iowa CIty, IA, 6Univ. of California San Francisco, San Francisco, CA, 7Univ. of Delaware, Newark, DE

10:15 AM – 10:45 AM BREAK

Sponsored by

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P L E N A R Y S E S S I O N 7 – Y E A R I N R E V I E W

Moderated by: Tuhina Neogi, MD, PhD, FRCPC and Ingrid Meulenbelt, PhD10:45 AM – 11:00 AM Rehabilitation & OutcomesHall 1 Natalie Collins, PT, PhD

11:00 AM – 11:15 AM OA Biology Joanna Sherwood, PhD

11:15 AM – 11:30 AM OA Clinical Lisa Mandl, MD, MPH

11:30 AM – 11:45 AM Genetics, Genomics & Epigenetics Matlock Jeffries, MD

11:45 AM – 12:00 PM Biomarkers Fatima Saberi Hosnijeh, MD, PhD

12:00 PM – 12:15 PM Imaging Miika Nieminen, PhD

12:15 PM – 12:30 PM Mechanics Lou Defrate, PhD

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POSTER PRESENTATIONS

OA: CARTILAGE & BONE91 INCREASED SUSCEPTIBILITY TO DEVELOP SPONTANEOUS AND SEVERE POST-TRAUMATIC OSTEOARTHRITIS IN DOT1L-DEFICIENT MICE F. M. CORNELIS, A. DE ROOVER, L. STORMS, A. HENS, R. J. LORIES, S. MONTEAGUDO; KU LEUVEN, LEUVEN, Belgium

92 CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 2 AS A NOVEL THERAPEUTIC TARGET AGAINST OSTEOARTHRITIS E. Mevel, Y. Li, U. Dadwal, A. Huls, M. Allen, D. Burr, U. Sankar; Indiana Univ. Sch. of Med., Indianapolis, IN

93 HYPOMORPHIC CONDITIONAL DELETION OF E11/PODOPLANIN IN THE SUBCHONDRAL BONE PROTECTS AGAINST LOAD-INDUCED OSTEOARTHRITIS

K. A. Staines1, E. Ikpegbu2, B. Javaheri3, A. K. Amin4, D. N. Clements2, D. J. Buttle5, A. A. Pitsillides3, C. Farquharson2; 1Edinburgh Napier Univ., Edinburgh, United Kingdom, 2Univ. of Edinburgh, Edinburgh, United Kingdom, 3Royal Vet. Coll., London, United Kingdom, 4NHS Lothian, Edinburgh, United Kingdom, 5Univ. of Sheffield, Sheffield, United Kingdom

94 HIGH-BANDWIDTH ATOMIC FORCE MICROSCOPY (AFM) BASED RHEOLOGY OF MURINE CARTILAGE REVEALS DEGENERATION OF COLLAGEN IX KNOCK OUT MICE CARTILAGE COMPARED TO WILD TYPE CARTILAGE IN TERMS OF EQUILIBRIUM AND DYNAMIC FLUID-SOLID INTERACTION PROPERTIES

R. Oftadeh1, J. Heilig2, F. Zaucke3, A. Niehoff4,5, A. J. Grodzinsky1,6; 1Dept. of Biological Engineering, Massachusetts Inst. of Technology, Cambridge, MA, 2Cologne Ctr. for Musculoskeletal Biomechanics, Med. Faculty, Köln, Germany, 3Dr. Rolf M. Schwiete Res. Unit for Osteoarthritis, Orthopaedic Univ. Hosp. Friedrichsheim gGmbH, Frankfurt, Germany, 4Inst. of Biomechanics and Orthopaedics, German Sport Univ. Cologne, Köln, Germany, 5Cologne Ctr. for Musculoskeletal Biomechanics, Med. Faculty, Univ. of Cologne, Köln, Germany, 6Dept. of Mechanical Engineering, Massachusetts Inst. of Technology, Cambridge, MA

95 IMPLICATION OF 14-3-3epsilon AS A POTENTIAL ALARMIN IN BONE/CARTILAGE COMMUNICATION IN OSTEOARTHRITIS. M. MILLERAND, L. SUDRE, A. RAVAT, A. PONS, F. BERENBAUM, C. JACQUES; Sorbonne Univ., Univ. Paris 6, INSERM (UMR_S938) and DHU i2B,

PARIS, France

96 BCP CRYSTALS DRIVE CHONDROCYTE HYPERTROPHIC DIFFERENTIATION VIA BINDING WNT LIGANDS AND ACTIVATION OF CANONICAL WNT SIGNALING

J. Bertrand1, T. Kräft2, Y. Nitschke2, F. Rutsch2, F. Liote3, T. Pap2; 1Otto-von-Guericke Univ. Magdeburg, Magdeburg, Germany, 2Univ. Hosp. Münster, Münster, Germany, 3Univ. Paris Diderot, Sorbonne Paris Cité, Inserm, Paris, France

97 THE CARDIOLIPIN-STABILIZING PEPTIDE SS-31 PROTECTS CHONDROCYTES FROM PERACUTE, MECHANICALLY-DEPENDENT MITOCHONDRIAL DEPOLARIZATION AND PRESERVES CHRISTAE STRUCTURE AFTER CARTILAGE INJURY

L. R. Bartell, L. A. Fortier, L. J. Bonassar, I. Cohen, M. L. Delco; Cornell Univ., Ithaca, NY

98 SM04690, A WNT PATHWAY INHIBITOR: ANTI-INFLAMMATORY AND CARTILAGE PROTECTIVE EFFECTS IN PRECLINICAL OSTEOARTHRITIS MODELS

V. Deshmukh, T. Seo, C. J. Swearingen, Y. Yazici; Samumed, San Diego, CA

99 METHYLATION OF 4-AMINOBUTYRATE AMINOTRANSFERASE (ABAT) BY DNMY3B REGULATES CHONDROCYTES METABOLISM AND THE DEVELOPMENT OF OSTEOARTHRITIS (OA)

J. Shen, C. wang, D. Li, T. wang, A. McAlinden, R. O’Keefe; washington Univ., St Louis, MO

100 THROUGH-THICKNESS PATTERNS OF SHEAR STRAIN CHANGE WITH PROGRESSIVELY OSTEOARTHRITIC HUMAN CARTILAGE F. Maier1, C. G. Lewis2, D. M. Pierce1; 1Univ. of Connecticut, Storrs, CT, 2Hartford Hlth.care, Hartford, CT

101 CHONDROCYTE-SPECIFIC RUNX2 OVEREXPRESSION ACCELERATES CARTILAGE DEGENERATION FOLLOWING TRAUMATIC INJURY S. E. Catheline, M. E. Chang, C. J. Dean, M. J. Zuscik, J. H. Jonason; Univ. of Rochester, Rochester, NY

102 CAM MORPHOLOGY OF THE HIP ARISES BEFORE, AND DOES NOT FURTHER INCREASE AFTER CLOSURE OF THE PROXIMAL FEMORAL GROWTH PLATE IN YOUTH SOCCER PLAYERS: A PROSPECTIVE STUDY WITH A MINIMUM OF 5-YEAR FOLLOW-UP.

P. van Klij, M. P. Heijboer, A. Z. Ginai, J. A. Verhaar, J. H. Waarsing, R. Agricola; Erasmus Med. Ctr., Rotterdam, Netherlands

103 CHONDROCYTE LIN28A OVEREXPRESSION PROTECTS CHONDROCYTE FROM OSTEOARTHRITIS PHENOTYPE Y. Jouan1,2, J. Sanna1, A. Latourte1,3, C. Cherifi1, k. Ea1,2, M. Cohen-Solal1,2, E. Hay1,2; 1INSERM U1132, paris, France, 2Univ. paris 7, Paris, France, 3Hosp.

lariboisiere, Paris, France

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104 BLOCKAGE OF SPHINGOSIN 1 PHOSPHATE S1P/S1PR PATHWAY PREVENTS FROM OSTEOARTHRITIS IN MICE BY REDUCING CHONDROCYTE CATABOLISM.

C. Cherifi1, A. Latourte2, O. Cuvillier3, K. Ea4, S. Vettorazzi5, J. Tuckermann5, P. Richette4,2, E. Hay1,4, M. Cohen-Solal1,4; 1INSERM U1132, paris, France, 2Hôpital Lariboisiere, Paris, France, 3Université de Toulouse, Toulouse, France, 4Univ. Paris7, Paris, France, 5Univ. of Ulm, Ulm, Germany

105 MECHANICAL LOADING COMBINED WITH BONE-MARROW MESENCHYMAL STROMAL CELLS INDUCES ECTOPIC BONE FORMATION IN A MEDIAL MENISCUS DESTABILIZATION MODEL

C. Carballo1,2, Y. Nakagawa1, A. Lebaschi1, S. Wada1, J. Green1, D. Wang1, A. Hall1, T. Uppstrom1, Z. Album1, M. Otero1, J. Brito2, S. Rodeo1; 1Hosp. for Special Surgery, New York, NY, 2Univ.e Federal do Rio de Janeiro, Rio de Janeiro, Brazil

106 LONGITUDINAL CHANGES IN T2 MAPPING OF KNEE CARTILAGE FOLLOWING RAPID AND SUBSTANTIAL WEIGHT LOSS S. Jafarzadeh1, J. Tamez2,3, S. Totterman3, M. Clancy1, D. T. Felson1; 1Boston Univ. Sch. of Med., Boston, MA, 2Tecnologico de Monterrey, Escuela de Med.,

Monterrey, Mexico, 3Qmetrics Technologies, Rochester, NY

107 ASSESSMENT OF THE EFFECTS OF EXERCISE ON A MURINE MODEL OF OA C. Huesa1, L. Dunning1, K. MacDougall1, A. Ortiz2, M. Villaluz3, M. Fegen1, A. Crilly1, G. Litherland1, R. van ‘t Hof4, C. Goodyear5, J. C. Lockhart1; 1Univ. of the

West of Scotland, Glasgow, United Kingdom, 2Univ. of Leuven, Leuven, Belgium, 3Dalhousie Univ., Halifax, NS, Canada, 4Univ. of Liverpool, Liverpool, United Kingdom, 5Univ. of Glasgow, Glasgow, United Kingdom

108 PREHYPERTROPHIC TO HYPERTROPHIC DIFFERENTIATION OF CHONDROCYTES INDUCES IL-34 EXPRESSION, A NEW CYTOKINE WITH POTENTIAL OSTEOCHONDRAL JUNCTION REMODELING ACTIVITY IN OSTEOARTHRITIS

S. van Eegher1, M-L. perez-Lozano1, I. Toillon1, A. Pigenet1, D. Citadelle1, S. Courtade-Gaïani2, D. Valour2, L. Grégoire2, S. Malbos1, G. Nourissat3, A. Sautet4, M-H. Lafage-Proust5, P. Pastoureau6, G. Rolland-Valognes2, F. de Ceuninck6, F. Berenbaum1, X. Houard1; 1Sorbonne Univ., Paris, France, 2Servier Res. Inst., Croissy-sur Seine, France, 3Ramsay, Générale de Santé, Paris, France, 4Assistance Publique - Hôpitaux de Paris, Paris, France, 5Université Jean Monnet, Saint-Priest en Jarez, France, 6Servier Res. Inst., Neuilly sur Seine, France

109 IMPAIRMENT OF HYDROGEN SULFIDE SYNTHESIS IN CHONDROCYTES UNDER HIGH GLUCOSE ENVIRONMENT: A LINK BETWEEN TYPE 2 DIABETES AND OSTEOARTHRITIS.

C. Vaamonde Garcia1,2, E. F. Burguera2, F. Blanco2, R. Meijide-Faílde1; 1Tissue Engineering and Regenerative Med. Group. Univ.e da Coruña (UDC)., A Coruña, Spain, 2Reumatología. Inst. de Investigación Biomédica de A Coruña (INIBIC). Completo Hosp.ario Univ.rio de A Coruña (CHUAC), Sergas., A Coruña, Spain

110 KNOCKDOWN OF POSTN ATTENUATES OSTEOARTHRITIS VIA TGF-β/SMAD SIGNALLING PATHWAY J. Ouyang1, L. Huang2, C. Zeng1, D. Cai1, H. Fang1; 1The Third Affiliated Hosp. of Southern Med. Univ., Guangzhou, China, 2Sun Yat-sen Mem. Hosp. of Sun Yat-

sen Univ., Guangzhou, China

111 3D OSTEOCYTE MORPHOLOGY AND VOLUME OF CHONDROCYTE CLUSTERS ARE MODULATED WITH OSTEOARTHRITIS SEVERITY M. A. Finnilä1,2, S. S. Karhula1, D. M. Cooper3,4, M. Valkealahti5, A. Joukainen6,2, D. Miller4, H. Nieminen7, H. Kröger6,2, R. K. Korhonen2, P. P. Lehenkari1,5, S.

Saarakkala1,5; 1Univ. of Oulu, Oulu, Finland, 2Univ. of Eastern Finland, Kuopio, Finland, 3Univ. of Saskatchewan, Saskatoon, SK, Canada, 4Canadian Light Source Inc., Saskatoon, SK, Canada, 5Oulu Univ. Hosp., Oulu, Finland, 6Kuopio Univ. Hosp., Kuopio, Finland, 7Aalto Univ., Espoo, Finland

112 PROGRAMMED CELL DEATH AND TOLL-LIKE RECEPTOR ACTIVATION IN ARTICULAR CARTILAGE J. Stolberg-Stolberg1, A. Böttcher1, J. Sherwood1, M. Sambale1, M. Raschke1, T. Pap1, J. Bertrand2; 1Univ.sklinikum Münster, Muenster, Germany, 2Univ.sklinikum

Magdeburg, Magdeburg, Germany

113 STRAIN AND MODEL SPECIFIC DIFFERENCES IN MOUSE MODELS OF OSTEOARTHRITIS A. Ratneswaran1, B. To2, B. A. Russell2, F. Beier2,3; 1Dalhousie Univ., Halifax, NS, Canada, 2Western Univ., London, ON, Canada, 3Children’s Hlth.Res. Inst.,

London, ON, Canada

114 FIBRILLIN-1 MUTANT MICE (TIGHT SKIN) SHOW INCREASED SPONTANEOUS AND TRAUMA-INDUCED OSTEOARTHRITIS DEVELOPMENT. B. Poulet; Univ. of Liverpool, Liverpool, United Kingdom

115 CD14 DEFICIENCY DAMPENS OSTEOCLASTOGENESIS AND ALTERS BONE REMODELING IN A MURINE MODEL OF OSTEOARTHRITIS C. Zhou1,2, V. Nguyen1,2, R. Smalley1, N. Sambamurthy1,2, G. R. Dodge1,2, C. R. Scanzello1,2; 1Corporal Michael J. Crescenz VA Med. Ctr., Philadelphia, PA, 2Univ.

of Pennsylvania Perelman Sch. of Med., Philadelphia, PA

116 CONTROLLED RELEASE OF CELECOXIB INHIBITS INFLAMMATION AND SUBCHONDRAL BONE CHANGES IN A RAT MODEL OF OSTEOARTHRITIS

A. R. Tellegen1, I. Jansen2, B. Pouran2, H. De Visser2, R. E. Thomas1, M. J. Kik1, G. C. Grinwis1, J. C. Thies3, N. Woike3, G. Mihov3, P. J. Emans4, B. P. Meij1, l. B. Creemers2, M. A. Tryfonidou1; 1Utrecht Univ., Utrecht, Netherlands, 2Univ. Med. Hosp., Utrecht, Netherlands, 3DSM Res., Geleen, Netherlands, 4Univ. Med. Hosp., Maastricht, Netherlands

31 | FINAL PROGRAM

117 TEXTURE FEATURES FROM T2 MAPPING OF TALAR DOME CARTILAGE IN NORMAL VOLUNTEERS AND DANCERS H. J. Yu1, S. Horiuch1, A. Luk1, A. Rudd1, J. Ton1, E. Kuoy1, J. Russell2, K. Sharp1, H. Yoshioka1; 1Univ. of California, Irvine, CA, 2Ohio Univ., Athens, OH

118 THE GINGER DERIVATE 6-SHOGAOL AS A TREATMENT IN OSTEOARTHRITIS. MODULATION OF CHONDROCYTE HYPERTROPHY AND MATRIX CALCIFICATION.

P. Gratal, A. Lamuedra, A. Mediero, G. Herrero-Beaumont, R. Largo; Bone and Joint Res. Unit, Rheumatology Dept., Inst. de Investigación Sanitaria Fundación Jimenez Díaz, MADRID, Spain

119 CRITICAL AND SUB-CRITICAL LOAD-INDUCED KNEE INJURIES PROMOTE LONG TERM PAIN AND IMPAIRED LOCOMOTION IN MICE. S. Ishihara1, C. Blaker2,3, R. Miller1, E. Clarke2, C. Little3, A-M. Malfait1; 1Div. of Rheumatology, Rush Univ. Med. Ctr., Chicago, IL, 2Murray Maxwell Biomechanics

Lab., Inst. of Bone and Joint Res., Kolling Inst., Northern Sydney Local Hlth.District, Sydney Med. Sch., Univ. of Sydney, St. Leonards, Australia, 3Raymond Purves Bone and Joint Res. Lab., Inst. of Bone and Joint Res., Kolling Inst., Northern Sydney Local Hlth.District, Sydney Med. Sch., Univ. of Sydney, St. Leonards, Australia

120 LASER ABLATION MACHINED SECTIONS PERMIT CORRELATIVE STUDIES OF HDMPS BY X-RAY MICROTOMOGRAPHY, OPTICAL AND SCANNING ELECTRON MICROSCOPY

A. Boyde1, D. Mills1, L. A. Ranganath2, J. A. Gallagher2; 1Queen Mary Univ. of London, London, United Kingdom, 2Univ. of Liverpool, Liverpool, United Kingdom

121 INHIBITION OF AUTOTAXIN ATTENUATES HIGH-FAT DIET-INDUCED OR SURGICALLY-INDUCED ACCELERATION OF OSTEOARTHRITIS P. Datta, S. Nakamura, E. Rossomacha, H. Endisha, C. Younan, K. H. Borada, K. E. Pritchett, N. N. Mahomed, R. Gandhi, J. S. Rockel, M. Kapoor; Krembil Res.

Inst., TORONTO, ON, Canada

122 CELLULAR AND MOLECULAR MECHANISMS OF SUBCHONDRAL BONE SCLEROSIS IN HIP OSTEOARTHRITIS: THE POTENTIAL ROLES OF MULTIPOTENTIAL STROMAL CELLS AND OSTEOCYTES

D. C. Ilas1, S. M. Churchman1, J. Aderinto2, P. V. Giannoudis1, D. G. McGonagle1, E. Jones1; 1Leeds Inst. of Rheumatic and Musculoskeletal Med., Univ. of Leeds, Leeds, United Kingdom, 2Leeds Teaching Hosp. NHS Trust, Leeds, United Kingdom

123 MEASURING THE PROGRESSION OF TRAUMA INDUCED OSTEOARTHRITIS IN CCN2 DEFICIENT MICE M. Jaffa, L. Ramos-Mucci, C. Keenan, G. Bou-Gharios, B. Poulet; Univ. of Liverpool, Liverpool, United Kingdom

124 ROLE OF ARTICULAR CARTILAGE VOLUME IN DEFINING NORMAL, PRE- ARTHRITIC and OSTEOARTHRITIC KNEE: A CASE CONTROL STUDY

R. N. Srivastava1, S. R. SRIVASTAVA2, A. C. SHARMA2, S. RAJ3; 1KG Med. Univ., Lucknow, India, 2KG Med. Univ., LUCKNOW, India, 3Westminster Coll., Salt Lake City, UT

125 A GDF5 MUTANT INDUCES CHONDROGENESIS IN MESENCHYMAL STEM CELLS SIMILARLY TO GDF5 WILDTYPE BUT SHOWS A DECREASED OSTEOGENIC POTENTIAL

T. Mang1, K. Kleinschmidt-Doerr1, F. Ploeger2, A. Schoenemann1, S. Lindemann1, A. Gigout1; 1Merck KGaA, Darmstadt, Germany, 2Biopharm GmbH, Eppelheim, Germany

126 TRANSFORMING GROWTH FACTOR BETA INDUCED PROTEIN (TGFBI), A NOVEL PLAYER IN OSTEOARTHRITIS M. Ruiz1, M. Maumus1, G. Fonteneau1, X. Houard2, F. Berenbaum2, X. Rannou3, C. Jorgensen1, D. Noel1; 1Inserm u1183, Montpellier, France, 2Inserm UMR-S938,

Hôpital Saint-Antoine, Paris, France, 3Inserm u1124, Hôpital Cochin, Paris, France

127 LONG TERM CYCLIC COMPRESSION OF ARTICULAR CARTILAGE ALTERS EXTRACELLULAR MATRIX TURNOVER A. Engstrøm1,2, A-C. Bay-Jensen1, M. A. Karsdal1, C. S. Thudium1; 1Nordic BioSci., Herlev, Denmark, 2Univ. of Copenhagen, Copenhagen, Denmark

128 SUBCHONDRAL BONE PLATE INTEGRITY IS CLOSELY ASSOCIATED WITH SUBCHONDRAL TRABECULAR BONE HOMEOSTASIS IN OSTEOARTHRITIS

G. Li1, T. Cheng2, N. Pavlos2, C. Zhang1, M. Zheng2; 1Shanghai Jiaotong Univ., Shanghai, China, 2The Univ. of Western Australia, Perth, Australia

129 COMPONENT RATIO OF CARTILAGE AND BONE PARTS OF OSTEOPHYTE IN EARLY-STAGE KNEE OA -A SPORTOLOGY CORE STUDY Y. Negishi1, M. Ishijima1, H. Kaneko1, T. Aoki2, L. Liu1, H. Arita1, M. Momoeda1, S. Hada1, Y. Tamura2,3, Y. Watada2,3, R. Kawamori2,3, K. Kaneko1,2; 1Dept. of Med.

for Orthopaedics and Motor Organ, Juntendo Univ. Graduate Sch. of Med., Bunkyo-ku,Tokyo, Japan, 2Sportology Ctr., Juntendo Univ. Graduate Sch. of Med., Bunkyo-ku,Tokyo, Japan, 3Dept. of Metabolism & Endocrinology, Juntendo Univ. Graduate Sch. of Med, Bunkyo-ku,Tokyo, Japan

130 CCN2 DEFICIENCY IN CHONDROCYTES DOES NOT EXACERBATE OSTEOARTHRITIS IN TRAUMA-INDUCED MOUSE MODELS C. Keenan1, P. Milner1, I. Kanakis1, A. Carter1, D. Abraham2, A. Leask3, R. Van ‘T Hof1, G. Bou-Gharios1, B. Poulet1; 1Univ. of Liverpool, Liverpool, United Kingdom,

2Univ. Coll. London, London, United Kingdom, 3Western Univ., London, ON, Canada

131 EGFR / MIG-6 SIGNALLING IN OSTEOARTHRITIS M. R. Bellini, M. A. Pest, F. Beier; Univ. of Western Ontario, London, ON, Canada

32 | FINAL PROGRAM

132 SUBCHONDRAL BONE/CARTILAGE: A FUNCTIONAL UNIT? BONE DENSITY AND CARTILAGE THICKNESS ARE POSITIVELY CORRELATED IN NON OSTEOARTHRITIC AND NEGATIVELY CORRELATED IN OSTEOARTHRITIC KNEES - A COMBINED 3D ANALYSIS USING CT ARTHROGRAPHY.

P. Omoumi, H. Babel, B. Jolles-Haeberli, J. Favre; Univ. Hosp. of Lausanne, Lausanne, Switzerland

133 ANTI-RHEUMATIC AGENTS NAPROXEN AND METHOTREXATE AFFECT SKELETAL DEVELOPMENT IN SKELETALLY IMMATURE MICE M. M. Caron1, T. M. Castermans1, B. van Rietbergen2, M. J. Haartmans1, L. W. van Rhijn1, T. J. Welting1, A. M. Witlox1; 1Maastricht Univ. Med. Ctr., Maastricht,

Netherlands, 2Eindhoven Univ. of Technology, Eindhoven, Netherlands

134 CHANGES IN THE SIZE OF HYPERTHROPHIC CHONDROCYTES IN ARTICULAR CARTILAGE IN OSTEOARTHRITIS. P. Gratal, I. Prieto-Potín, A. Lamuedra, A. Villalvilla, R. Largo, G. Herrero-Beaumont, A. Mediero; IIS-Fundación Jiménez Díaz, MADRID, Spain

135 THE TRANSLATIONAL LANDSCAPE IN ARTICULAR CHONDROCYTES TREATED WITH INTERLEUKIN-1 REVEALS NOVEL POTENTIAL PLAYERS IN OSTEOARTHRITIS.

V. Kolupaeva1, O. Katsara1, M. Attur2; 1NYU Langone Med. Ctr., New York, NY, 2NYU HJD, New York, NY

136 MILD OSTEOARTHRITIS IN ADULT MICE INDUCED BY ENDOPLASMIC RETICULUM STRESS K. L. Posey, F. Chiu, A. Veerisetty, J. L. Alcorn, J. T. Hecht; Univ. of Texas Med. Sch. at Houston, Houston, TX

137 DOES HYLAN G-F20 IMPROVES NEEDLE LAVAGE AND TRIAMCINOLONE INJECTION IN THE TREATMENT IN MODERATE HIP OSTEOARTHRITIS?

M. U. Rezende1, H. M. Gurgel1, G. C. Campos2, M. I. Hissadomi1, R. Frucchi1, A. F. Pailo1, T. Pasqualin1; 1Faculdade Med. USP, Sao Paulo, Brazil, 2Univ.e de Campinas, Campinas, Brazil

138 M1673 (GDF5 MUTANT) INCREASES MATRIX PRODUCTION IN PRIMARY PORCINE AND HUMAN OSTEOARTHRITIC CHONDROCYTES T. Mang1, K. Kleinschmidt-Doerr1, F. Ploeger2, S. Lindemann1, A. Gigout1; 1Merck KGaA, Darmstadt, Germany, 2Biopharm GmbH, Eppelheim, Germany

139 MRI-BASED CHARACTERIZATION OF DEFORMATIONS IN ENZYMATICALLY DEGRADED ARTICULAR CARTILAGE M. I. Pastrama1, A. Caixado Ortiz1, L. Zevenbergen1, N. Famaey2, W. Gsell3, C. P. Neu4, U. Himmelreich3, I. Jonkers1; 1KU Leuven, Dept. of Movement Sci.,

Human Movement Biomechanics Res. Group, Leuven, Belgium, 2KU Leuven, Dept. of Mechanical Engineering, Soft Tissue Biomechanics Group, Leuven, Belgium, 3KU Leuven, Dept. of Imaging and Pathology, BioMed. MRI, Leuven, Belgium, 4Univ. of Colorado, Dept. of Mechanical Engineering, Boulder, CO

140 INDIAN HEDGEHOG SIGNALING IS IN RESPONSE TO THE BLUNT TRAUMA IN ARTICUAR CARTILAGE Y. ZHU1,2, J. He2, P. G. Alexander2, C. Luo1, C. Zhang1, R. Tuan2; 1Dept. of Orthopaedic Surgery, Shanghai Jiaotong Univ., Affiliated Sixth People’s Hosp.,

Shanghai, China, 2Ctr. for Cellular and Molecular Engineering, Dept. of Orthopaedic Surgery,Univ. of Pittsburgh, Pittsburgh, PA

141 VITAMIN D STATUS IS ASSOCIATED WITH MINERALIZATION OF OSTEOPHYTE IN PATIENTS WITH KNEE OSTEOARTHRITIS M. Momoeda1, H. Kaneko1, L. Liu2,1, S. Hada1, H. Arita1, T. Aoki2, M. Kinosita1, Y. Negishi1, Y. Okada3, K. Kaneko1,2, M. Ishijima1,2; 1Dept. of Med. for Motor Organ,

Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 2Sportology Ctr., Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 3Dept. of Pathophysiology for Locomotive and Neoplastic Diseases, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan

142 THE MECHANICAL AND STRUCTURAL CHANGES OF RAT CARTILAGES UNDER MECHANICAL LOADING: AN IN VITRO WEAR TEST OF WHOLE RAT JOINTS

l. tong, z. hao, c. wan, h. cai, s. wen; Tsinghua Univ., beijing, China

143 MYRICETIN ATTENUATES OSTEOARTHRITIS BY BLOCKADE OF THE IL-1β/MAPK PATHWAY X. Liu, H. Fang, C. Zeng, D. Cai; The Third Affiliated Hosp. of Southern Med. Univ., Guangzhou, China

144 ESTABLISHMENT OF AN EX VIVO HUMAN OSTEOCHONDRAL TISSUE MODEL FOR EVALUATION OF DMOADS C. Netzer, M. Müller, S. Schären, J. Geurts; Univ. Hosp. of Basel, Basel, Switzerland

145 A COMBINED MODEL OF DESTABILISATION OF THE MEDIAL MENISCUS AND CARTILAGE DAMAGE ACCELERATES OSTEOPHYTOGENESIS IN OSTEOARTHRITIS

K. McCulloch1, C. Huesa1, L. Dunning1, R. van ‘t Hof2, J. Lockhart1, C. Goodyear3; 1Univ. of the West of Scotland, Paisley, United Kingdom, 2Univ. of Liverpool, Liverpool, United Kingdom, 3Glasgow Univ., Glasgow, United Kingdom

146 HISTOLOGICAL SCORING SYSTEM FOR PERIARTICULAR BONE CHANGES OF The OSTEOARTHRITIS K. Nagira, Sr.1,2, S. Miyagi, Sr.1, Y. Ikuta1, M. Lotz, Sr.1; 1The Scripps Res. Inst., San Diego, CA, 2Tottori Univ., Yonago, Japan

33 | FINAL PROGRAM

147 THE EFFECT OF VARUS ALIGNMENT AND OBESITY ON THE ONSET AND PROGRESSION IN MEDIAL KNEE OSTEOARTHRITIS: CASE CONTROL STUDY FROM THE LONGITUDINAL EVALUATION OF MATSUDAI KNEE OSTEOARTHRITIS SURVEY.

Y. Tomiyama1, G. Omori2, Y. Koga3, K. Nishino4, H. Koga5, T. Mochizuki5, Y. Higano6, O. Tanifuji5; 1Dept. of Orthopedic Surgery, Nagaoka Chuo Genaral Hosp., Niigata, Japan, 2Dept. of Hlth.and Sports, Faculty of Hlth.and Sci., Niigata Univ. of Hlth.and Welfare, Niigata, Japan, 3Ninohji Onsen Hosp., Niigata, Japan, 4Niigata Inst. for Hlth.and Sports Med., Niigata, Japan, 5Div. of Orthopedic Surgery, Dept. of Regenerative and Transplant Med., Niigata Univ. Graduate Sch. of Med. and Dental Sci., Niigata, Japan, 6Dept. of Orthopedic Surgery, Tsuruoka Municipal Shonai Hosp., Yamagata, Japan

148 CYCLIC TENSILE STRAIN AND PHARMACOLOGICAL TREATMENT AFFECTS HUMAN CHONDROCYTES UNDER INFLAMMATORY AND NON-INFLAMMATORY CONDITIONS

B. Lohberger1,2, L. Weigl3,4, W. Kullich5,6, A. Leithner1,2, B. Steinecker-Frohnwieser7,6; 1Med. Univ. Graz, Graz, Austria, 2Dept. of Orthopaedic Surgery, Graz, Austria, 3Med. Univ. Vienna, Vienna, Austria, 4Dept. of Special Anaesthesia and Pain Therapy, Vienna, Austria, 5Ludwig Boltzmann Cluster for Arthritis and Rehabilitation, Saalfelden, Austria, 6Ludwig Boltzmann Dept. for Rehabilitation of Internal Diseases, Saalfelden, Austria, 7Ludwig Boltzmann Cluster for Arthritis and Rehabilitation, Graz, Austria

149 HISTOPATHOLOGICAL CHANGES IN THE PATELLOFEMORAL JOINT OF A RAT MODEL OF OSTEOARTHRITIS INDUCED BY MONOSODIUM IODOACETATE

I. Takahashi1,2, T. Matsuzaki3, H. Kuroki2, M. Hoso3; 1Section of Rehabilitation, Kanazawa Univ. Hosp., Kanazawa city, Japan, 2Dept. of Motor Function Analysis, Human Hlth.Sci., Graduate Sch. of Med., Kyoto Univ., Kyoto city, Japan, 3Div. of Hlth.Sci., Graduate Sch. of Med. Sci., Kanazawa Univ., Kanazawa city, Japan

150 TOWARDS THE ELUCIDATION OF THE ROLE OF OSTEOPROTEGERIN IN THE DEVELOPMENT OF OSTEOARTHRITIS A. Rodriguez Ruiz, E. Houtman, M. Van Hoolwerff, N. Lakenberg, R. G. Nelissen, I. Meulenbelt, Y. F. Ramos; Leiden Univ. Med. Ctr., Leiden, Netherlands

151 ROLE OF NORADRENALIN IN IL-1β-INDUCED CHONDROCYTE DEDIFFERENTIATION S. Speichert, K. El Bagdadi, A. Meurer, F. Zaucke, Z. Jenei-Lanzl; Orthopedic Univ. Hosp. Friedrichsheim gGmbh, Frankfurt am Main, Germany

152 HYALURONIC ACID & NATRIUM SUCCINATE IN TREATMENT OF EXPERIMENTAL OSTEOARTHRITIS O. Burianov1, L. Khimion2, T. Omelchenko1, Y. Sobolevskyi1, H. Havryliuk2, L. Smolina2; 1Bogomolets Natl. Med. Univ., Kyiv, Ukraine, 2Shupyk Natl. Med. Academy

of Postgraduate Ed., Kyiv, Ukraine

153 DIFFERENT REGULATORY ROLES OF TNF-α AND IL-6 IN OVARIECTOMY INDUCED BONE LOSS S. Zhu1,2, H. He2, C. Gao2,3, G. Luo4, Y. Xie4, H. Wang2, L. Tian4, X. Chen4, X. Yu4, C. He2,3; 1Arthritis Res. Canada, Univ. of British Columbia, Richmond, BC,

Canada, 2Rehabilitation Ctr., West China Hosp., Sichuan Univ., Chengdu, China, 3Inst. for Disaster Management and Reconstruction, Sichuan Univ.-The Hong Kong Polytechnic Univ., Chengdu, China, 4Lab. of Endocrinology and Metabolism, Dept. of Endocrinology, Natl. Key Lab. of Biotherapy/Collaborative Innovation Ctr. of Biotherapy and Cancer Ctr., West China Hosp., Sichuan Univ., Chengdu, China

BONE BIOLOGY154 PROTEOMIC ANALYSIS OF OSTEOBLASTS

SECRETOME PROVIDES NEW INSIGHTS IN MECHANISMS UNDERLYING OSTEOARTHRITIS SUBCHONDRAL BONE SCLEROSIS C. Sanchez, G. Mazzucchelli, C. Lambert, F. Comblain, E. DePauw, Y. Henrotin; Univ. of Liège, Liège, Belgium

155 EFFECT OF DENOSUMAB ON BONE FORMATION MARKER P1NP H. Tanigawa1,2, T. Maeda1, K. Kumagai1, S. Imai1; 1Shiga Univ. of Med. Sci., Otsu, Japan, 2Kusatsu Gen. Hosp., Kusatsu-city, Shiga, Japan

156 GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA J. H. Hughes1, K. Liu1, H. Sutherland1, P. J. Wilson1, A. T. Hughes1,2, A. M. Milan1,2, L. R. Ranganath1,2, J. A. Gallagher1, G. Bou-Gharios1; 1Univ. of Liverpool,

Liverpool, United Kingdom, 2Royal Liverpool and Broadgreen Univ. Hosp. NHS Trust, Liverpool, United Kingdom

157 3D ANALYSIS OF LOCAL GREY-LEVEL VARIANCE FROM MICRO-CT IMAGES IS ASSOCIATED WITH OSTEOCYTE CELLULARITY IN HUMAN OSTEOARTHRITIC SUBCHONDRAL BONE

S. S. Karhula1, M. A. Finnilä1,2, D. M. Cooper3, D. Miller4, M. Valkealahti5, A. Joukainen6,2, P. Lehenkari1,5, H. Kröger6,2, R. K. Korhonen2, H. J. Nieminen7,1, S. Saarakkala1,5; 1Univ. of Oulu, Oulu, Finland, 2Univ. of Eastern Finland, Kuopio, Finland, 3Univ. of Saskatchewan, Saskatoon, SK, Canada, 4Canadian Light Source Inc., Saskatoon, SK, Canada, 5Oulu Univ. Hosp., Oulu, Finland, 6Kuopio Univ. Hosp., Kuopio, Finland, 7Aalto Univ., Espoo, Finland

158 OVARIECTOMY INDUCED BONE LOSS IS ANTAGONIZED BY PULSED ELECTROMAGNETIC FIELDS (PEMFS) AND TNF-α AND IL-6 GENE KNOCKOUTS IN A SIMILAR MECHANISM

S. Zhu1,2, H. He2, H. Wang2, C. Gao2,3, Q. Wang2, D. Wang4, Q. Wei2, X. Yu5, C. He2,3; 1Arthritis Res. Canada, Univ. of British Columbia, Richmond, BC, Canada, 2Rehabilitation Ctr., West China Hosp., Sichuan Univ., Chengdu, China, 3Inst. for Disaster Management and Reconstruction, Sichuan Univ.-The Hong Kong Polytechnic Univ., Chengdu, China, 4Sch. of Aeronautics and Astronautics, Sichuan Univ., Chengdu, China, 5Lab. of Endocrinology and Metabolism, Dept. of Endocrinology, Natl. Key Lab. of Biotherapy/Collaborative Innovation Ctr. of Biotherapy and Cancer Ctr., West China Hosp., Sichuan Univ., Chengdu, China

34 | FINAL PROGRAM

159 OVEREXPRESSION OF E2F1 IN CHONDROCYTES INCREASES CARTILAGINOUS CALLUS FORMATION AND CONSEQUENT BONE REGENERATION AFTER FRACTURE

P. Premnath, Y. Zhu, B. A. Besler, S. Boyd, R. Krawetz; Univ. of Calgary, Calgary, AB, Canada

160 IL37 INHIBITS PROTEOGLYCAN LOSS IN HUMAN OA CARTILAGE: LINK BETWEEN IL37 AND MMP3 E. van Geffen1, A. van Caam1, E. Blaney Davidson1, C. Thudium2, A-C. Bay-Jensen2, P. van der Kraan1; 1Radboudumc, Nijmegen, Netherlands, 2Nordic BioSci.,

Copenhagen, Denmark

CARTILAGE BIOLOGY & MATRIX BIOCHEMISTRY161 LIN28A IS OVEREXPRESSED IN OSTEOARTHRITIS AND IS ESSENTIAL FOR THE STABILITY AND HIGH LEVEL EXPRESSION OF IL-6 AND COX-

2 IN HUMAN CHONDROCYTES I. Ahmad, M. Y. Ansari, N. M. Khan, T. M. Haqqi; Northeast Ohio Med. Univ., Rootstown, OH

162 VIPERIN REGULATES CHONDROGENIC DIFFERENTIATION VIA CXCL10 PROTEIN SECRETION M. M. Steinbusch1, M. M. Caron1, D. A. Surtel1, P. J. van Dijk1, F. Friedrich2, B. Zabel3, L. W. van Rhijn1, M. J. Peffers4, T. J. Welting1; 1Maastricht Univ. Med. Ctr.,

Maastricht, Netherlands, 2Univ. Heart Ctr. Freiburg, Freiburg, Germany, 3Otto-von-Guericke-Univ. of Magdeburg, Magdeburg, Germany, 4Inst. of Ageing and Chronic Disease, Liverpool, United Kingdom

163 MICRORNA-193B MODULATES CHONDROGENESIS AND CARTILAGE DEGENERATION VIA HISTONE DEACETYLASE 3 F. Meng, Z. Li, Z. Zhang, D. Long, A. He, W. Liao; First Affiliated Hosp. of SunYat-sen Univ., Guang Zhou, China

164 LOSS OF WNT9A AND WNT4 CAUSES DEGENERATIVE JOINT ALTERATIONS S. Teufel, P. Köckemann, U. König, C. Hartmann; Univ. Hosp. Münster, Inst. for Musculoskeletal Med., Münster, Germany

165 SUPPRESSOR OF CYTOKINE SIGNALING 3 MODULATES TRANSFORMING GROWTH FACTOR-β SIGNALING IN HUMAN CHONDROCYTES THROUGH THE INHIBITION OF THE JAK/STAT3 PATHWAY

R. Wiegertjes, F. A. van de Loo, E. N. Blaney Davidson, P. M. van der Kraan; Radboudumc, Nijmegen, Netherlands

166 CEMIP IS A NEW KEY REGULATOR OF CHONDROCYTES TRANSDIFFERENTIATION INVOLVED IN OSTEOARTHRITIC CARTILAGE FIBROSIS C. Deroyer1, E. Charlier1, S. Neuville1, O. Malaise1, B. Relic1, A. Chariot2, M. Malaise1, D. de Seny1; 1Lab. of Rheumatology, GIGA Res., Univ. of Liège, CHU Liège,

Liège, Belgium, 2GIGA-Molecular Biology of Diseases, Univ. of Liège, Liège, Belgium

167 UBIQUITIN-PROTEIN LIGASE UBR5 IS A POTENT SUPPRESSOR OF SPONTANEOUS HETEROTOPIC OSSIFICATION AND ARTICULAR CARTILAGE DAMAGE

D. Mellis1, S. Peluso1, K. Staines2, S. Ralston1, D. Salter1, R. Hill1, M. Ditzel1; 1MRC IGMM, Univ. of Edinburgh, Edinburgh, United Kingdom, 2Napier Univ., Edinburgh, United Kingdom

168 UROCORTIN EXPRESSION IN CARTILAGE IS ATTENUATED IN A NON-INVASIVE MOUSE MODEL OF POST TRAUMATIC OSTEOARTHRITIS F. Ter Heegde1, R. C. Jones2, T. R. Jackson2, C. De Pascale3, I. C. Locke3, T. N. Board4, S. M. Richardson2, P. A. Townsend2, K. M. Lawrence2; 1Royal Vet. Coll.,

London, United Kingdom, 2Univ. of Manchester, Manchester, United Kingdom, 3Univ. of Westminster, London, United Kingdom, 4Wrightington Hosp., Wigan, United Kingdom

169 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL (TRPC6) AS A REGULATOR OF CXCR2-MEDIATED ARTICULAR CARTILAGE HOMEOSTASIS

J. Sherwood1, M. Sambale1, J. Bertrand2, F. Dell’Accio3, T. Pap1; 1Univ. Hosp. Muenster, Muenster, Germany, 2Otto-von-Guericke Univ. of Magdeburg, Magdeburg, Germany, 3Queen Mary Univ. of London, London, United Kingdom

170 EXT1 AND EXT2 REGULATE CHONDROGENESIS BY MODULATION OF WNT SIGNALING X. WANG, S. MONTEAGUDO, R. LORIES; KU LEUVEN, LEUVEN, Belgium

171 IDENTIFICATION OF A HIGH IMPACT MUTATION IN THE FN1 GENE IN EARLY-ONSET OSTEOARTHRITIS FAMILY M. van Hoolwerff, Y. F. Ramos, N. Lakenberg, M. Kloppenburg, K. Ye, E-W. E. Lameijer, R. G. Nelissen, P. Slagboom, I. Meulenbelt; Leiden Univ. Med. Ctr.,

Leiden, Netherlands

172 ZCCHC6 (TUT7) DELETION INHIBIT THE EXPRESSION OF IL-6 AND MMP-13 AND REDUCES THE SEVERITY OF POST-TRAUMATIC OSTEOARTHRITIS IN A MURINE MODEL

M. Y. Ansari, N. M. Khan, T. M. Haqqi; Northeast Ohio Med. Univ., Rootstown, OH

35 | FINAL PROGRAM

173 THE ROLE OF COLLAGEN IX IN THE OSSIFICATION OF THE MURINE FEMORAL HEAD J. Heilig1, F. Zaucke2, A. Niehoff1,3; 1Cologne Ctr. for Musculoskeletal Biomechanics, Univ. of Cologne, Cologne, Germany, 2Dr. Rolf M. Schwiete Res. Unit

for Osteoarthritis, Orthopädische Univ.sklinik Friedrichsheim, Frankfurt, Germany, 3Inst. of Biomechanics and Orthopaedics, German Sport Univ. Cologne, Cologne, Germany

174 INVESTIGATING THE ROLE OF RETINOID X RECEPTOR IN CARTILAGE DEVELOPMENT AND HOMEOSTASIS M-G. Sun, A. Ratneswaran, H. Dupuis, F. Beier; Univ. of Western Ontario, London, ON, Canada

175 BMP-7 ENHANCES RIBOSOMAL RNA LEVELS IN CHONDROCYTES VIA BAPX1-NKX3.2 E. Ripmeester, M. Caron, L. W. van Rhijn, T. Welting; MUMC+, Maastricht, Netherlands

176 DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

B. P. Norman1, C. Wing Ying2, H. Sutherland1, P. J. Wilson1, N. B. Roberts3, M. J. Duer4, H. Oschkinat2, L. R. Ranganath3, J. A. Gallagher1; 1Inst. of Ageing & Chronic Disease, Univ. of Liverpool, Liverpool, United Kingdom, 2Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany, 3Liverpool Clinical Lab., Royal Liverpool & Broadgreen Univ. Hosp. NHS Trust, Liverpool, United Kingdom, 4Dept. of Chemistry, Univ. of Cambridge, Cambridge, United Kingdom

177 EXPLORING AND EXPLOITING A CILIOME-PROTEASE-MATRIX REGULATORY AXIS DISTURBED IN OSTEOARTHRITIS I. Collins1, C. R. Coveney1, F. K. Bangs2, L. Troeberg1, T. L. Vincent1, A. K. Wann1; 1The Kennedy Inst. of Rheumatology, Univ. of Oxford, Oxford, United Kingdom,

2The Dept. of Oncology, Univ. of Oxford, Oxford, United Kingdom

178 A COL9A3 EXON 3 SKIPPING MOUSE AS NOVEL MODEL FOR MULTIPLE EPIPHYSEAL DYSPLASIA AND EARLY-ONSET OSTEOARTHRITIS S. Lecci, C. G. Miles, M. D. Briggs, D. A. Young; Newcastle Univ., Newcastle upon Tyne, United Kingdom

179 EVALUATION OF THE POTENTIAL CHONDROPROTECTIVE EFFECTS OF 26S PROTEASOME INHIBITORS IN AN IN VITRO CARTILAGE EXPLANT MODEL

C. C. SHU, V. Ravi, Y. Liu, S. M. Smith, A. W. Ashton, C. B. Little; Kolling Inst. of Med. Res., SYDNEY, Australia

180 DIFFERENTIAL REGULATION OF MATRIX METALLOPROTEINASES BY ANANDAMIDE AND 2-ARACHIDONOYLGLYCEROL IN HUMAN OSTEOARTHRITIC CHONDROCYTES

J. Mlost, M. Kostrzewa, K. Starowicz; Inst. of Pharmacology, Krakow, Poland

181 DIFFERENTIAL GENE EXPRESSION IN ANKLE COMPARED TO KNEE CARTILAGE: MIGHT THIS EXPLAIN THE DIFFERENCE IN OSTEOARTHRITIS PREVALENCE?

A. S. Miller1, P. Hodgson1, E. J. Blain2; 1Univ. Hosp. of Wales, Cardiff, United Kingdom, 2Arthritis Res. UK Biomechanics & Bioengineering Ctr., Cardiff Univ., Cardiff, United Kingdom

182 OSTEOARTHRITIS-ASSOCIATED CATABOLIC FACTOR, INTERLEUKIN-1B DOWNREGULATES CHONDROCYTE ENERGY METABOLISM THROUGH THE MODULATION OF ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AND SIRTUIN 1 IN OA.

K. Yudoh, N. Yui, H. Kobayashi, T. Kumai; St. Marianna Univ. Sch. of Med., Kawasaki City, Japan

183 IMPACT OF HUMAN PLATELET LYSATE ON THE EXPANSION AND CHONDROGENIC CAPACITY OF CULTURED HUMAN CHONDROCYTES FOR CARTILAGE CELL THERAPY.

J. G. Sykes, J. Kuiper, J. B. Richardson, K. T. Wright, N. J. Kuiper; Univ. of Keele, The Robert Jones & Agnes Hunt Orthopaedic Hospital, United Kingdom

184 EXOSOMES DERIVED FROM MIR-92A-3P-OVEREXPRESSING HUMAN MESENCHYMAL STEM CELLS ENHANCE CHONDROGENESIS AND PREVENT THE DEVELOPMENT OF OSTEOARTHRITIS

g. mao, Y. KANG, Z. ZHANG, Z. ZHANG, W. LIAO; the first affiliated Hosp., Sun Yat-sen Univ., guangzhou, China

185 SIMULATING OSTEOARTHRITIS IN VITRO WITH HUMAN SCAFFOLD-FREE 3D CARTILAGE TRANSPLANTS M-C. Weber1, I. Ponomarev2, T. Gaber1,3, F. Buttgereit1,3, A. Lang1,3; 1Charité-Univ.smedizin Berlin, Berlin, Germany, 2Res. Ctr. of Med. Technology and

Biotechnology, Bad Langensalza, Germany, 3German Rheumatism Res. Ctr., Berlin, Germany

186 FIRST STEPS TOWARDS THE IN VITRO SIMULATION OF AN ARTHRITIC JOINT A. Lang1,2, A. Damerau1,2, M-C. Weber1, F. Buttgereit1,2, T. Gaber1,2; 1Charité-Univ.smedizin Berlin, Berlin, Germany, 2German Rheumatism Res. Ctr., Berlin, Germany

187 CATABOLIC EFFECTS OF FIBROBLAST GROWTH FACTOR-1 ON CHONDROCYTES THROUGH MATRIX METALLOPROTEINASE-13 AND CONNECTIVE TISSUE GROWTH FACTOR/CCN2: POSSIBLE ROLE IN OSTEOARTHRITIS.

A. Elseoudi1, T. Abd El Kader2,3, T. Nishida1, E. Aoyama2, T. Eguchi4, M. Takigawa2, S. Kubota1,2; 1Biochemistry and Molecular Dentistry, Dental school, Okayama Univ., Okayama, Japan, 2Advanced Res. Ctr. for Oral and Craniofacial Sci., Dental school, Okayama Univ., Okayama, Japan, 3Singapore Inst. of Technology, Singapore, Singapore, 4Dental Pharmacology, Dental school, Okayama Univ., Okayama, Japan

36 | FINAL PROGRAM

188 ANALYSIS OF ANION CHANNEL ACTIVITY IN CHONDROCYTES IN VITRO MODEL OF OSTEOARTHRITIS. K. Kumagai1, F. Toyoda1, C. Staunton2, U. Sharif2, R. Lewis3, T. Maeda1, H. Tanigawa1, A. Mobasheri3, R. Barrett-Jolley2; 1Shiga Univ. of Med. Sci., Otsu, Japan,

2Univ. of Liverpool, Liverpool, United Kingdom, 3Univ. of Surrey, Guilford, United Kingdom

189 RAMAN SPECTROSCOPY CAN NON-INVASIVELY DISTINGUISH BETWEEN OCHRONOTIC AND NON-OCHRONOTIC CARTILAGE A. M. Taylor1, D. Jenks1, V. D. Kammath1, B. Norman2, J. P. Dillon2, J. A. Gallagher2, L. R. Ranganath2, J. G. Kerns1; 1Lancaster Univ., Lancaster, United Kingdom,

2Univ. of Liverpool, Liverpool, United Kingdom

190 RIBOSOMAL PROFILING AND SECRETOME ANALYSIS IDENTIFY THAT INTERLEUKIN-1B DRIVEN CYTOKINE/CHEMOKINE RELEASE FROM CHONDROCYTIC CELLS IS UNDERPINNED BY DIFFERENTIAL TRANSLATION

B. T. McDermott1, M. J. Peffers1, B. McDonagh2, S. R. Tew1; 1Univ. of Liverpool, Liverpool, United Kingdom, 2Natl. Univ. of Ireland, Galway, Galway, Ireland

191 THE COX-2 SELECTIVE BLOCKER INHIBIT CYTOKINE-INDUCED APOPTOSIS IN ISOLATED ARTICULAR CHONDROCYTES. K. Kumagai, F. Toyoda, M. Kubo, T. Maeda, H. Tanigawa, N. Okumura, T. Yayama, H. Matsuura, S. Imai; Shiga Univ. of Med. Sci., Otsu, Japan

192 THE EFFECT OF 4E-BP1 ON OSTEOARTHRITIS-RELATED GENE EXPRESSION IN TGF-β1-STIMULATED CHONDROCYTES M. Lee1,2, J-R. Kim1,2, H. Hwang1,2, H. Kim1,2; 1Hallym Univ. Sacred Heart Hosp., Gyeonggi-do, Korea, Republic of, 2Inst. for Skeletal Aging, Hallym Univ.,

Chunchon, Korea, Republic of

193 3’-SIALYLLACTOSE PREVENTS OSTEOARTHRITIC DEVELOPMENT BY SUPPRESSION OF CATABOLIC FACTOR EXPRESSION J. Jeon1,2, L. Kang2, C. Cho1,2, S. Yang1,2; 1Dept. of bioMed. Sci.s, Ajou Univ. Graduate school of Med., Suwon, Korea, Republic of, 2Dept. of pharmacology, Ajou

Univ. school of medicine, Suwon, Korea, Republic of

194 INVESTIGATING INTRASPECIES DIFFERENCES OF THE GROWTH PLATE OF SMALL AND LARGE BREED DOGS IN ORDER TO GAIN NEW INSIGHTS IN CARTILAGE BIOLOGY

M. Teunissen1, F. M. Riemers1, D. van Leenen2, M. J. Groot Koerkamp3, B. P. Meij1, A. Miranda-Bedate1, M. A. Tryfonidou1; 1Utrecht Univ., Utrecht, Netherlands, 2Univ. Med. Ctr. Utrecht, Utrecht, Netherlands, 3Princess Máxima Ctr. for pediatric oncology, Utrecht, Netherlands

195 SOX9 TRANSCRIPTIONAL ACTIVITY IS DIFFERENTIALLY REGULATED IN HEALTHY AND OSTEOARTHRITIC CHONDROCYTES K. Govindaraj, S. Khurana, M. Karperien, J. N. Post; Univ. of Twente, Enschede, Netherlands

CELL SIGNALING196 CARTILAGE INJURY SUPPRESSES ENDOGENOUS RETINOIC ACID THROUGH ACTIVATION OF TGFβ-ACTIVATED KINASE 1 (TAK1) L. Zhu, H. Ismail, A. Chanalaris, H. Muhammad, S. Lympany, T. L. Vincent; Kennedy Inst. of Rheumatology, Univ. of Oxford, Oxford, United Kingdom

197 THE DIFFERENTIAL REACTIVE OXYGEN SPECIES-BASED REGULATION OF MAPK SIGNALING CASCADES IN HUMAN ARTICULAR CHONDROCYTES J. Bolduc1, J. Collins1, S. Schwartz1, D. Little2, R. Loeser1; 1UNC-Chapel Hill, Chapel Hill, NC, 2Oakwood Univ., Huntsville, AL

198 INHIBITION OF THE COMPLEMENT SYSTEM COMPONENT C5 AS POSSIBLE TREATMENT IN OA M. Bollmann1, F. Colombo2, P. Marco2, L. De Maso2, K. Brandstädter3, C. H. Lohmann1, J. Bertrand1; 1Clinic of Orthopedic Surgery, Univ. Hosp. Magdeburg,

Magdeburg, Germany, 2Dept. of Life Sci., Univ. of Trieste, Trieste, Italy, 3Inst. of Legal Med., Univ. Hosp. Halle, Halle, Germany

199 JNK-DEPENDENT MODULATION OF THE PROTEASE SECRETOME PROFILE OF OSTEOARTHRITIC CARTILAGE H. M. Ismail, L. Troeberg, T. L. Vincent, J. Saklatvala; Univ. of Oxford, Oxford, United Kingdom

200 THE GATE TO CONTROLLING CHONDROGENIC DIFFERENTIATION: TRANSCRIPTIONAL REGULATION BY SOX9 IN ATDC5 CELLS M. M. Caron1, K. W. Derks1, L. Sanderink1, L. W. van Rhijn1, M. J. Peffers2, T. J. Welting1; 1Maastricht Univ. Med. Ctr., Maastricht, Netherlands, 2Inst. of Ageing and

Chronic Disease, Univ. of Liverpool, Liverpool, United Kingdom

201 RUNX2 AND SOX9 PROTEIN MOBILITY CORRELATES TO OSTEOGENIC AND CHONDROGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

S. Khurana, K. Govindaraj, M. Karperien, J. N. Post; Univ. of Twente, Enschede, Netherlands

202 TRANSGLUTAMINASE-2 IN OSTEOARTHRITIS: MMP-13 PRODUCTION THROUGH ENHANCED FOXO3A NUCLEAR TRANSLOCATION S. Han1,2, M-S. Han2, H-R. Park2, G-W. Kim1,2, J-H. Kim3; 1Daegu Fatima Hosp., Daegu, Korea, Republic of, 2Lab. for arthritis and bone biology, Fatima Res. Inst.,

Daegu, Korea, Republic of, 3Andong Gen. Hosp., Andong, Korea, Republic of

203 WOUND HEALING FACTOR IL1α: A PLAUSIBLE TRIGGER FOR ZINC-MEDIATED CARTILAGE EROSION? W. Thompson, C. Hilkens, J. Loughlin, L. Reynard; Newcastle Univ., Newcastle upon Tyne, United Kingdom

37 | FINAL PROGRAM

204 EFFECTS OF NOTCH-1 KNOCKDOWN ON THE PROLIFERATION AND THE DIFFERENTIATION OF HUMAN OSTEOARTHRITIS CHONDROCYTES M. Minguzzi1,2, V. Panichi1,2, L. Cattini2, G. Filardo3, E. Mariani1,2, R. Borzì2; 1Dept. of Med. and Surgical Sci., Univ. of Bologna, Bologna, Italy, 2Lab. of

Immunorheumatology and Tissue Regeneration, Rizzoli Orthopaedic Inst., Bologna, Italy, 3Lab. of Nanobiotechnology , Rizzoli Orthopaedic Inst., Bologna, Italy

205 INVESTIGATIONS OF CYTOKINE INTERPLAY WITH AN IN VITRO MODEL OF OSTEOARTHRITIS M. Neidlin1, E. Chantzi2, G. Macheras3, M. Gustafsson2, L. Alexopoulos1; 1Mechanical Engineering Dept., Natl. Technical Univ. of Athens, Athens, Greece, 2Dept.

of Med. Sci., Uppsala Univ., Uppsala, Sweden, 34th Orthopaedic Dept., KAT Hosp., Athens, Greece

206 REGULATION OF ALPHA5 AND BETA1 INTEGRIN EXPRESSION BY OSTEOGENIC OR ADIPOGENIC DIFFERENTIATION AS WELL AS BY TGF BETA IN HUMAN HIP OA CHONDROCYTES

E. Charlier1, S. Neuville1, B. Relic1, C. Deroyer1, O. Malaise1, W. Kurth2, P. Gillet2, D. de Seny1, M. G. Malaise1; 1Lab. of Rheumatology_GIGA-R_CHU de Liège, Liège, Belgium, 2CHU de Liège_Orthopedic Surgery Dpt, Liège, Belgium

207 INCREASED SUSCEPTIBILITY TO IL-1 ACCELERATES OSTEOARTHRITIC CHANGE IN 3D-CULTURED CHONDROCYTES AND IN VIVO ANIMAL MODELS

Y. Takeda1,2, Y. Niki1, Y. Fukuhara1, Y. Fukuda1, K. Udagawa1, T. Kikuchi1, T. Miyamoto1, M. Matsumoto1, M. Nakamura1; 1Dept. of Orthopaedic Surgery, Keio Univ., Shinjuku-ku, Tokyo, Japan, 2Dept. of Orthopaedic Surgery, Saiseikai Central Hosp., MInato-ku, Tokyo, Japan

CELL STRESS RESPONSES208 CORRELATION OF SEVERITY OF PRIMARY KNEE OSTEOARTHRITIS WITH THE LIPID PEROXIDATION MARKER IN SYNOVIAL FLUID P. Sharma1, J. Shukla2, S. Sharma1, N. Garg1, P. Gupta1; 1Shri Guru Ram Rai Inst. of Med. and Hlth. Sci., Dehradun, India, 2Shri Guru Ram Rai Inst. of Med. and

Hlth.Sci., Dehradun, India

209 PIEZO1 EXPRESSION IS INCREASED IN RESPONSE TO NON-INVASIVE IMPACT OF MOUSE KNEE JOINT R. C. Jones1, F. Ter Heegde2, T. R. Jackson1, M. O’Brien1, T. N. Board3, S. M. Richardson1, P. A. Townsend1, K. M. Lawrence1; 1Univ. of Manchester, Manchester,

United Kingdom, 2Royal Vet. Coll., London, United Kingdom, 3Wrightington Hosp., Wigan, United Kingdom

210 PALMITATE-INDUCED ER STRESS NEGATIVELY REGULATES AUTOPHAGY IN PRIMARY MENISCUS CELLS R. Yammani, A. Mallik; Wake Forest Sch. of Med., Winston Salem, NC

211 MITOCHONDRIAL DNA VARIATION INFLUENCES THE JOINT DETERIORATION IN A CONPLASTIC MOUSE MODEL OF AGING I. Rego-Perez, Sr.1, A. Lechuga, Jr.2, M. Scotece, Jr.1, P. Filgueira-Fernández, Jr.1, S. Pértega, Sr.3, J. Enríquez, Sr.2, F. Blanco, Sr.1; 1Servicio de Reumatología.

Inst. de Investigación Biomédica de A Coruña (INIBIC). Complexo Hosp.ario Univ.rio de A Coruña (CHUAC), Sergas. Univ.e da Coruña (UDC), A Coruña, Spain, 2Grupo de Genética funcional del sistema de fosforilación oxidativa. Centro Natl. de Investigaciones Cardiovasculares Carlos III, Madrid, Spain, 3Unidad de Epidemiología Clínica y Bioestadística. Inst. de Investigación Biomédica de A Coruña (INIBIC). Complexo Hosp.ario Univ.rio de A Coruña (CHUAC), Sergas. Univ.e da Coruña (UDC), A Coruña, Spain

AGING212 OPPOSITE ROLES OF PANNEXINS IN POST-TRAUMATIC VERSUS AGING ASSOCIATED OSTEOARTHRITIS P. M. Moon, Z. Shao, S. Penuela, D. W. Laird, F. Beier; Univ. of Western Ontario, London, ON, Canada

213 SENESCENCE OF HUMAN OSTEOARTHRITIC OSTEOBLASTS IS ATTENUATED BY ASCORBIC ACID M. G. Burger1, A. Steinitz1, J. Geurts2, B. E. Pippenger2, D. J. Schäfer1, I. Martin2, A. Barbero2, K. Pelttari2; 1Univ. Hosp. Basel, Basel, Switzerland, 2Univ. Hosp.

Basel and Univ. of Basel, Basel, Switzerland

214 IN VIVO ASSESSMENT OF NORMAL KNEE CARTILAGE AGING IN HUMANS VIA T2 MRI RELAXATION TIME QUANTIFICATION - A 6-YEAR LONGITUDINAL STUDY FROM THE OSTEOARTHRITIS INITIATIVE

J. Baal, J. Neumann, G. Joseph, A. Lorenzo, K. Tang, L. Nardo, M. C. Nevitt, C. E. McCulloch, T. M. Link, U. Heilmeier; Univ. of California San Francisco, San Francisco, CA

215 PHYSICAL ACTIVITY CAN INFLUENCE PAIN INTENSITY IN COMMUNITY LIVING ELDERLY SUBJECTS WITH OSTEOARTHRITIS S. R. Pais1,2, M. Palma3,4, A. Roque5, A. Marreiros1,6; 1Univ. of Algarve-Dept. of BioMed. Sci. and Med., Faro, Portugal, 2Ctr. for BioMed. Res. (CBMR),

Faro, Portugal, 3Univ. of Algarve-Sch. of Hlth., Faro, Portugal, 4Ctr. for Hlth.Res. and Dev., Faro, Portugal, 5Univ. of Algarve-Centro Internacional Sobre o Envelhecimento, Faro, Portugal, 6Algarve BioMed. Ctr.- ABC, Faro, Portugal

38 | FINAL PROGRAM

216 AGE-RELATED CHANGES IN MICRORNAS EXPRESSION IN MOUSE CRUCIATE LIGAMENTS Y. Ashraf Kharaz1, K. Whysall1, J. Hurst2, E. Comerford1,3; 1Univ. of Liverpool, Inst. of Ageing and Chronic Disease, Liverpool, United Kingdom, 2Univ. of Liverpool,

Inst. of Integrative Biology, Neston, United Kingdom, 3Univ. of Liverpool, Inst. of Vet. Sci., Neston, United Kingdom

217 REPRESSION OF NOVEL GENES IMPLICATED IN AUTOPHAGY - RELATED MECHANISMS IN THE CARTILAGE OF SENESCENT RAT C. Arias1, D. S. Abdalla2, N. Saavedra1, K. Saavedra1, M. Alvear1, B. Vásquez1, M. del Sol1, L. A. Salazar1; 1Univ. de La Frontera, Temuco, Chile, 2Univ. de São Paulo,

São Paulo, Brazil

218 EFFECT OF AGING ON TIBIOFEMORAL CARTILAGE AND MENISCUS STIFFNESS CONSTANT B. Ritchie, J. C. Kupper, P. Zandiyeh, G. Kuntze, G. Sharma, J. L. Ronsky; Univ. of Calgary, Calgary, AB, Canada

219 ROLE OF SYSTEMIC HYPERTENSION IN CELL SENESCENCE AND SUBCHONDRAL BONE DISTURBANCE OF KNEE JOINT P. Chan1, M. Au2, W. Yang1, C. Yan1, K. Chiu1, C. Wen2; 1The Univ. of Hong Kong, Hong Kong, Hong Kong, 2The Hong Kong Polytechnic Univ., Hong Kong, Hong

Kong

220 INHIBITION OF INTERLEUKIN-17-INDUCED EFFECTS IN OSTEOARTHRITIS - AN IN VITRO STUDY J. Y. Mimpen, A. J. Carr, S. G. Dakin, S. J. Snelling; Univ. of Oxford, Oxford, United Kingdom

ANGIOGENESIS, AND SYNOVIAL TISSUE BIOLOGY221 THE DIFFERENCE IN SYNOVITIS (SYNOVIAL MEMBRANE) AND ANGIOGENESIS BETWEEN YOUNG OBESE, YOUNG LEAN AND OLD LEAN

PEOPLE WITH PRIMARY KNEE OSTEOARTHRITIS M. Al Mutani, J. Alsousou, M. Roebuck, S. Frostick; Univ. of Liverpool, Liverpool, United Kingdom

222 NOVEL SUSTAINED RELEASING TRIAMCINOLONE ACETONIDE POLYESTERAMIDE MICROPARTICLE PLATFFORM TO REDUCE PAIN IN THE KNEE OF A SYNOVIATIS RAT MODEL

N. Woike1, I. Jansen2, A. Tellegen3, L. Creemers2, M. Tryfonidou3, G. Mihov1, J. C. Thies1, K. Schrijver2, S. Versteeg4, N. Eijkelkamp5; 1DSM BioMed. B.V., Geleen, Netherlands, 2Dept. of Orthopedics, Univ. Med. Ctr. Utrecht, the Netherlands, Utrecht, Netherlands, 3Dept. of Clinical Sci. of Companion Animals, Utrecht, Netherlands, 4Lab. for Translational immunity , Univ. Med. Ctr. Utrecht, the Netherlands, Utrecht, Netherlands, 5Lab. for Translational immunity , Univ. Med. Ctr. Utrecht, the Netherlands, Geleen, Netherlands

SYNOVITIS223 MICRORNA 27B-3P PROMOTES EXTRACELLULAR MATRIX PRODUCTION IN OSTEOARTHRITIS SYNOVIAL FIBROBLASTS. G. Tavallaee1,2, S. A. Ali2,3, G. M. Mitchell2, R. Gandhi4, M. Kapoor1,2; 1Univ. of Toronto, Dept. of Lab. Med. and Pathobiology, Toronto, ON, Canada, 2Div. of

Genetics and Dev., Krembil Res. Inst., Toronto, ON, Canada, 3Arthritis Program, Univ. Hlth.Network, Toronto, ON, Canada, 4Div. of Orthopaedic Surgery, Krembil Res. Inst., Toronto, ON, Canada

224 THE ANTERIOR TIBIOTALAR FAT PAD AS A SOURCE OF PAIN AND INFLAMMATION IN OSTEOARTHRITIS OF THE ANKLE: ANATOMY, HISTOLOGY AND IMAGING

S. Clockaerts1,2, F. M. Cornelis1, J. Van Der Bouwhede2, P. Byttebier2, E. E. Vereecke3, R. J. Lories1; 1KU Leuven, Leuven, Belgium, 2AZ Groeninge, Kortrijk, Belgium, 3KU Leuven (KULAK), Kortrijk, Belgium

225 ADIPONECTIN IS A POTENTIAL MEDIATOR OF FIBROSIS IN KNEE OSTEOARTHRITIS S. A. Ali, M. Kapoor, R. Gandhi; Univ. Hlth.Network, TORONTO, ON, Canada

226 THE COLL2-1 PEPTIDE OF COLLAGEN TYPE II: A NEW ACTOR OF SYNOVITIS IN OSTEOARTHRITIS C. Lambert1, D. Borderie2, F. Rannou2, Y. Henrotin1; 1Univ. of Liège, Liège, Belgium, 2Univ. Paris Descartes, Paris, France

227 CHRONIC SYNOVIAL INFLAMMATION PLAY IMPORTANT ROLES TO ESTABLISH RESIDUAL PAIN IN MONOIODOACETIC ACID INDUCED ARTHRITIS RAT MODEL

T. Hoshino, K. Tsuji, H. Onuma, H. Katagiri, I. Sekiya, T. Muneta, H. Koga; Tokyo Med. and Dental Univ., Tokyo, Japan

228 FUNCTIONAL FOLATE RECEPTOR CELL-ASSOCIATED INFLAMMATORY CYTOKINES PREDICT THE PROGRESSION OF KNEE OSTEOARTHRITIS

M-F. Hsueh1,2, Y. Lu3, S. S. Wellman1,4, M. P. Bolognesi1,4, V. B. Kraus1,5; 1Duke Univ., Durham, NC, 2Duke Molecular Physiology Inst., Durham, NC, 3Endocyte, Inc, West Lafayette, IN, 4Dept. of Orthopaedic Surgery, Durham, NC, 5Div. of Rheumatology, Dept. of Med., Durham, NC

39 | FINAL PROGRAM

INFLAMMATION AND IMMUNITY229 DEVELOPMENT OF AN ORGANOTYPIC MICROFLUIDIC MODEL TO REPRODUCE MONOCYTE EXTRAVASATION PROCESS IN THE

OSTEOARTHRITIC JOINT C. Mondadori1,2, R. Visone2, M. Rasponi2, A. Redaelli2, M. Moretti1,3, S. Lopa1; 1Cell and Tissue Engineering Lab., IRCCS Galeazzi Orthopaedic Inst., Milan, Italy,

2Dept. of Electronics, Information & Bioengineering, Politecnico di Milano, Milan, Italy, 3Regenerative Med. Technologies Lab, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland

230 MORE SEVERE OA JOINT PATHOLOGY IN HUMAN APOE-ε4 AS COMPARED TO APOE-ε3 TRANSGENIC MICE: APOE-ISOFORMS AS POSSIBLE RISK FACTOR FOR INFLAMMATORY OSTEOARTHRITIS DEVELOPMENT?

M. van den Bosch, N. Kruisbergen, W. de Munter, A. Sloetjes, P. van den Kraan, A. Blom, P. van Lent; Radboud Univ. Med. center, Nijmegen, Netherlands

231 LUMICAN REGULATION OF TOLL-LIKE RECEPTOR 4- MEDIATED INFLAMMATION IN OSTEOARTHRITIS G. Barreto1, B. Senturk2, L. Colombo1, P. Neidenbach3, G. Salzmann3, M. Rottmar2, M. Zenobi-Wong1; 1ETH Zürich, Zurich, Switzerland, 2Swiss Federal Lab. for

Materials Sci. and Technology, Dübendorf, Switzerland, 3Schulthess Clinic, Zurich, Switzerland

232 TRPA1 AS A FACTOR AND DRUG TARGET IN OSTEOARTHRITIS: TRPA1 (TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1) MEDIATES INTERLEUKIN-6 EXPRESSION IN CHONDROCYTES

E. Nummenmaa1, M. Hämäläinen1, A. Pemmari1, L. J. Moilanen1, R. M. Nieminen1, T. Moilanen1,2, K. Vuolteenaho1, E. Moilanen1; 1The Immunopharmacology Res. Group, Faculty of Med. and Life Sci., Univ. of Tampere and Tampere Univ. Hosp., Tampere, Finland, 2Coxa Hosp. for Joint Replacement, Tampere, Finland

233 MARKERS ASSOCIATED WITH SYNOVIAL INFLAMMATION CAN IDENTIFY WOMEN AT HIGH RISK OF DEVELOPING PAINFUL RADIOGRAPHIC KNEE OSTEOARTHRITIS: A PROSPECTIVE COMMUNITY BASED COHORT.

S. Kluzek1, C. S. Thudium2, A-C. Bay-Jensen3, M. A. Karsdal4, M. Sanchez1, G. Cairns5, T. Spector6, D. Hart6, C. Cooper1, J. L. Newton1, N. Arden1; 1Univ. of Oxford, OXFORD, United Kingdom, 2Dept. of Rheumatology, Nordic BioSci., Herlev, Denmark, 3Nordic BioSci., Head of Rheumatology, Res. and Biomarkers, Herlev, Denmark, 4Nordic BioSci., Herlev, Denmark, 5Univ. of Bristol, Bristol, United Kingdom, 6King’s Coll., London, United Kingdom

234 INVOSSA-K INDUCES AN ANTI-INFLAMMATORY ENVIRONMENT IN A RAT MIA MODEL VIA MACROPHAGE POLARIZATION H. Lee1, K. Choi1, H. Kim1, D. Kim1, H. Lee1, Y. Lee1, B. Lee2, S. Kim1, M. Lee3, H. Choi1; 1Kolon Life Sci. Inc, Seoul, Korea, Republic of, 2Tissuegene Inc, Rockville,

MD, 3Seoul Natl. Univ. Coll. of Med., Seoul, Korea, Republic of

235 NEUTROPHIL EXTRACELLULAR VESICLES HAVE A CARTILAGE PROTECTIVE EFFECT DURING INFLAMMATORY ARTHRITIS. B. L. Thomas, H. R. Jones, L. V. Norling, S. E. Headland, C. Pitzalis, F. Dell’Accio, M. Perretti; Queen Mary Univ. London, London, United Kingdom

236 ADRENIC ACID AS A NOVEL ANTI-INFLAMMATORY PLAYER IN OSTEOARTHRITIS H. Brouwers1, H. Jonasdottir1, J. Kwekkeboom1, C. Lopez-Vicario2, J. Claria2, J. Freysdottir3, I. Hardardottir3, T. Huizinga1, R. Toes1, M. Giera1, M. Kloppenburg1, A.

Ioan-Facsinay1; 1LUMC, Leiden, Netherlands, 2Univ. of Barcelona, Barcelona, Spain, 3Univ. of Iceland, Reykjavik, Iceland

237 EXPOSURE TO SECOND-HAND CIGARETTE SMOKE EXACERBATES THE PROGRESSION OF OA B. Liu, J. A. Weyand, B. R. Perez, C. Clark, K. Hirschi, B. J. Rose, J. A. Arroyo, P. R. Rogers, D. L. Kooyman; Brigham Young Univ., Provo, UT

238 NOVEL ADIPOKINE ASSOCIATED WITH OSTEOARTHRITIS: RETINOL BINDING PROTEIN 4 IS PRODUCED BY CARTILAGE AND CORRELATES WITHMATRIX METALLOPROTEINASESIN OSTEOARTHRITIS PATIENTS

M. Scotece1, A. Koskinen-Kolasa1, T. Moilanen1,2, E. Moilanen1, K. Vuolteenaho1; 1The Immunopharmacology Res. Group, Faculty of Med. and Life Sci., Univ. of Tampere, Tampere, Finland, 2Coxa Hosp. for Joint Replacement, Tampere, Finland

239 ESTABLISHMENT OF THE IN VIVO IMMUNOLOGICAL PROFILE IN COLLAGENASE INDUCED OSTEOARTHRITIS A. J. Burke, P. Mancuso, C. Dooley, T. Ritter, F. Barry, M. J. Murphy, A. E. Ryan; REMEDI, Galway, Ireland

240 DIFFERENTIAL RESPONSES TO EX VIVO POLARIZED MONOCYTES/MACROPHAGES IN A HUMAN OSTEOARTHRITIS JOINT EXPLANT CO-CULTURE M. Chan1, A. Gómez-Aristizábal2, R. Gandhi2, S. Viswanathan2,1; 1IBBME, Univ. of Toronto, Toronto, ON, Canada, 2Arthritis Program, Krembil Res. Inst., Toronto

Western Hosp., Toronto, ON, Canada

241 CHARACTERISATION OF SYNOVIAL FLUID CELLS OF EARLY OSTEOARTHRITIS PATIENTS J. K. Garcia1, C. Mennan1, S. Roberts1, J. Richardson1, P. Gallagher2, K. Wright1; 1Robert Jones Agnes Hunt Hosp. NHS Trust (Keele Univ.), Oswestry, United

Kingdom, 2Robert Jones Agnes Hunt Hosp. NHS Trust, Oswestry, United Kingdom

242 M1/M2 MACROPHAGES INDUCE CHONDRAL MMP/ADAMTS ENZYME SECRETION IN A DIRECT CO-CULTURE EXPERIMENT N. Rosshirt, T. Engbarth, T. Gotterbarm, S. Hagmann, B. Moradi; Univ. Hosp. Heidelberg, Heidelberg, Germany

40 | FINAL PROGRAM

243 3’-SIALYLLACTOSE INHIBITS INFLAMMATORY RESPONSE IN EXPERIMENTAL ARTHRITIS MODEL D. Kim1,2, L-J. Kang2, H. Lee1,2, H. Park1,2, S. Yang1,2; 1Dept. of BioMed. Sci., Ajou Univ. Graduate Sch. of Med., Suwon, Korea, Republic of, 2Dept. of

Pharmacology, Ajou Univ. Sch. of Med., Suwon, Korea, Republic of

244 GENE EXPRESSION IN ADVERSE REACTION TO METAL DEBRIS AROUND METAL-ON-METAL ARTHROPLASTY: AN RNA-SEQ-BASED STUDY A. Pemmari1, T. Leppänen1, T. Moilanen1,2, E. Moilanen1; 1The Immunopharmacology Res. Group, Faculty of Med. and Life Sci., Univ. of Tampere and Tampere

Univ. Hosp., Tampere, Finland, 2Coxa Hosp. for Joint Replacement, Tampere, Finland

245 MESENCHYMAL STEM CELLS IN CHRONIC JOINT INFLAMMATION L. Zaripova1, A. Midgley2, S. Christmas3, E. Baildam4, R. Oldershaw1; 1Dept. of Musculoskeletal Biology I, Inst. of Ageing and Chronic Disease, Univ. of Liverpool,

Liverpool, United Kingdom, 2Dept. of Women’s and Children’s Hlth., Alder Hey Children’s Hosp., Liverpool, United Kingdom, 3Dept. of Clinical Infection, Microbiol. and Immunology Inst. of Infection & Global Hlth., Univ. of Liverpool, Liverpool, United Kingdom, 4Dept. of Paediatric Rheumatology, Alder Hey Children’s NHS Fndn. Trust, Liverpool, United Kingdom

246 A NEOFUNCTIONALIZED GENE ZCCHC5 IS EXPRESSED IN CARTILAGE AND ITS DOWNREGULATION INHIBITS COL2A1 EXPRESSION AND ENHANCES THE EXPRESSION OF MMP-13 IN CHONDROCYTES

N. M. Khan, T. M. Haqqi; Northeast Ohio Med. Univ., Rootstown, OH

JOINT TISSUE ANABOLISM AND CATABOLISM247 EFFECT OF DOUBLE KNOCKOUT OF CARTILAGE-SPECIFIC MITOGEN-INDUCIBLE GENE 6 AND TRANSFORMING GROWTH FACTOR-

ALPHA ON JOINT HOMEOSTASIS B. C. To, M. A. Pest, F. Beier; Univ. of Western Ontario, London, ON, Canada

248 THE SYNOVIAL SECRETOME CONTRIBUTES TO CARTILAGE PATHOLOGY IN OSTEOARTHRITIS: A ROLE FOR EXOSOMES S. Asghar1, G. Litherland1, D. Meek2, J. Lockhart1, C. Goodyear3, A. Crilly1; 1Univ. of the West of Scotland, Paisley, United Kingdom, 2Queen Elizabeth Univ.

Hosp., Glasgow, United Kingdom, 3Univ. of Glasgow, Glasgow, United Kingdom

249 EX VIVO INHIBITION OF JAK AND IKK PRESERVES CARTILAGE FORMATION IN CATABOLICALLY STIMULATED BOVINE ARTICULAR CARTILAGE C. S. Thudium1, C. F. Kjelgaard-Petersen1, N. Sharma1, A. Mobasheri2, M. A. Karsdal1, A-C. Bay-Jensen1; 1Nordic BioSci. A/S, Herlev, Denmark, 2Dept. of Vet.

Preclinical Sci., Univ. of Surrey, Guildford, United Kingdom

250 DEVELOPMENT OF AN EQUINE CARPAL GROOVE MODEL TO STUDY EARLY CHANGES IN OSTEOARTHRITIS - A PILOT STUDY N. te Moller; Utrecht Univ., Utrecht, Netherlands

251 3’-SIALYLLACTOSE AMELIORATES THE ARTHRITIS-INDUCED CARTILAGE DESTRUCTION BY MMPS SUPPRESSION. H. Lee1,2, L-J. Kang1, D. Kim1,2, H. Park1,2, S. Yang1,2; 1Dept. of pharmacology, Ajou Univ. Sch. of Med., Suwon, Korea, Republic of, 2Dept. of BioMed. Sci., Ajou

Univ. Graduate Sch. of Med., Suwon, Korea, Republic of

252 CCL2 BUT NOT CCR2 IS REQUIRED FOR ARTICULAR CARTILAGE REGENERATION C. L. Jablonski, C. Leonard, P. Salo, R. Krawetz; Univ. of Calgary, Calgary, AB, Canada

CARTILAGE REPAIR253 GENETIC MODIFICATION OF HUMAN BONE MARROW ASPIRATES VIA DELIVERY OF rAAV VECTORS COATED ON PNASS-GRAFTED

POLY(ε-CAPROLACTONE) SCAFFOLDS J. K. Venkatesan1, A. Leroux2, J-S. Baumann2, A. Rey-Rico1, C. Falentin-Daudré2, J. Frisch1, H. Madry1, V. Migonney2, M. Cucchiarini1; 1Saarland Univ., Homburg,

Germany, 2Université Paris 13-UMR CNRS 7244-CSPBAT-LBPS-UFR SMBH, Bobigny, Paris, France

254 ENDOGENOUS MESENCHYMAL STEM CELLS CONTRIBUTE TO SMALL MOLECULE INDUCED AURICULAR CARTILAGE REGENERATION AFTER INJURY

N. U. Narendran1, K. Bertram1, C. Leonard1, T. M. Underhill2, R. Krawetz1; 1Univ. of Calgary, Calgary, AB, Canada, 2Univ. of British Columbia, Vancouver, AB, Canada

255 IN VIVO FORMATION OF STABLE HYALINE CARTILAGE BY TRANSPLANTATION OF NAIVE HUMAN BONE MARROW STROMAL CELLS J. Featherall1, S. A. Kuznetsov1, S. Burks2, A. Hailu-Lazmi3, N. Cherman1, L. Fernandez de Castro1, P. G. Robey1, R. Gorodetsky3; 1Natl. Inst. of Dental and

Craniofacial Res., NIH, Bethesda, MD, 2Natl. Inst. of BioMed. Imaging and Bioengineering, NIH, Bethesda, MD, 3Sharett Inst. of Oncology, Hadassah Hebrew Univ. Med. Ctr., Jerusalem, Israel

41 | FINAL PROGRAM

256 EFFECT OF HYALURONIC ACID-BASED VISCOSUPPLEMENTATION ON CARTILAGE MATERIAL PROPERTIES M. Gaumet1, I. Badoud2, P. Ammann2; 1TRB Chemedica Intl, Geneva, Switzerland, 2Univ. Hosp. Geneva, Geneva, Switzerland

257 NOREPINEPHRINE INDUCES MIGRATION BUT INHIBITS CHONDROGENIC DIFFERENTIATION OF SYONOVIAL ADIPOSE-DERIVED STEM CELLS K. El Bagdadi1, F. Zaucke1, A. Meurer1, R. H. Straub2, Z. Jenei-Lanzl1; 1Orthopedic Univ. Hosp. Friedrichsheim gGmbh, Frankfurt am Main, Germany, 2Univ. Hosp.

Regensburg, Lab. of Experimental Rheumatology and Neuroendocrine Immunology, Dept. of Internal Med., Regensburg, Germany

258 INHIBITORY EFFECT OF LENVATINIB, A MULTIPLE RECEPTOR TYROSINE KINASE INHIBITOR, ON OSTEOARTHRITIS. Y. Sogo1, T. Nagai2, T. Takahashi1, D. Takizawa1, M. Watanabe1, M. Sato1; 1Dept. of Orthopaedic Surgery, Surgical Sci., Tokai Univ. Sch. of Med., Kanagawa, Japan,

2Dept. of Orthopaedic Surgery, Tokai Univ. Oiso Hosp., Kanagawa, Japan

259 EFFECT OF DEXAMETHASONE, INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN, AND TOLL-LIKE RECEPTOR ANTAGONIST 242 (RESATORVID) ON GENE EXPRESSION IN EQUINE CHONDROCYTES IN A CHRONIC INFLAMMATION MODEL IN VITRO

L. C. Berg, M. Honoré, L. Bundgaard; Univ. of Copenhagen, Taastrup, Denmark

260 THE ROLE OF GCP-2 IN CARTILAGE DIFFERENTIATION AND REPAIR M. Alvarez Fallas1, S. Caxaria1, J. Sherwood2, F. Luyten3, C. Pitzalis1, F. Dell’Accio1; 1Queen Mary Univ. of London, London, United Kingdom, 2Univ. Hosp.

Münster, Münster, Germany, 3KU Leuven, Leuven, Belgium

261 ANALYSIS OF MICRO-RNAS IN EXOSOMES SECRETED BY HUMAN POLYDACTYLY-DERIVED CHONDROCYTE SHEETS E. TOYODA1, M. SATO1, M. MAEHARA1, T. TAKAHASHI1, T. TAKAGI1, K. NONAKA2, H. IIJIMA2, R. MATOBA2, H. AKUTSU3, A. UMEZAWA3, T.

AKAMATSU1, M. WATANABE1; 1TOKAI Univ., Sch. of Med., Kanagawa, Japan, 2DNA CHIP RESEARCH INC., TOKYO, Japan, 3Natl. CENTER FOR CHILD HEALTH AND DEVELOPMENT, TOKYO, Japan

262 RESULTS OF TREATMENT OF SCAFFOLD-FREE PELLET-TYPE AUTOLOGOUS CHONDROCYTES IMPLANTATION (CARTILIFETM) IN PATIENTS WITH KNEE CARTILAGE LESIONS. A MULTI-CENTER, ACTIVE-CONTROLLED, RANDOMIZED TRIAL

J. Lee; Biosolution Co., Ltd., Seoul, Korea, Republic of

263 IMAGE-GUIDED NEEDLE BIOPSY IN HARVESTING CHONDROCYTES FOR AUTOLOGOUS CHONDROCYTE IMPLANTATION (ACI): INITIAL FEASIBILITY STUDY WITH HUMAN CADAVERIC AND CLINICAL EXPERIENCE

B. Zikria1, N. Hafezi-Nejad2, I. Patten1, A. Haj-Mirzaian1, J. Ficke1, J. Wilckens1, S. Demehri1; 1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, 2Univ. System of Maryland, Baltimore, MD

264 CONSTRUCTION OF DEXAMETHASONE-CONJUGATED PEI COMPLEXES WITH POLYCISTRONIC SOX6, SOX9 AND SHANGPTL4 GENES FOR THE TREATMENT OF OSTEOARTHRITIS

G-I. Im, M-L. Kang, S-Y. Jeong; Dongguk Univ. Ilsan Hosp., Goyang, Korea, Republic of

265 EFFECTS OF SIMULATED MUSCLE EXERCISE ON CHONDROCYTE GENE EXPRESSION IN A 3D-ALGINATE BEAD MODEL SYSTEM Y-H. Chen1, C-H. Chou2, A. Khodabukus3, N. Bursac3, G. Truskey3, W. Kraus3, V. B. Kraus3; 1TSGH, Taipei, Taiwan, 2Duke Univ., Durham, NC, 3Duke Univ.,

Durham, NC

266 A NEW STRATEGY FOR AUTOLOGOUS CHONDROCYTE IMPLANTATION: AUTOLOGOUS MESENCHYMAL STEM CELL AND CHONDROCYTE IMPLANTATION “FIRST IN MAN” STUDY.

J. Wang1, J. Richardson2, A. Brown2, H. Tim1; 1Stoke-on-Trent, Staffordshire, United Kingdom, 2Robert Jones & Agnes Hunt Orthopaedic Hosp., Oswestry, United Kingdom

267 PEO-PPO-PEO MICELLES AS EFFECTIVE RAAV-MEDIATED DELIVERY SYSTEMS TO OVEREXPRESS SOX9 IN HUMAN OSTEOARTHRITIC ARTICULAR CHONDROCYTES

A. Rey-Rico, J. K. Venkatesan, G. Schmitt, H. Madry, M. Cucchiarini; Saarland Univ., Homburg, Germany

268 QUALITY APPRAISAL OF EVIDENCE FROM META-ANALYTIC STUDIES ON INTERVENTIONS FOR CARTILAGE DEFECTS OF THE KNEE Y. Hou1, D. Xing1, J. Lin1, Y. Chen2, Y. Ke1, R. Zhao1, K. Tao1; 1Peking Univ. People’s Hosp., Beijing, China, 2GRADE center China), Lanzhou Univ., Lanzhou, China

269 ANALYSIS OF DIFFERENTIALLY EXPRESSED GENES THROUGH SHEET FORMATION OF POLYDACTYLY -DERIVED CHONDROCYTES M. Maehara1, M. Sato1, E. Toyoda1, T. Takahashi1, E. Okada1, T. Takagi1, K. Nonaka2, H. Iijima2, R. Matoba2, H. Akutsu3, A. Umezawa3, T. Akamatsu1, M. Watanabe1;

1Tokai Univ. Sch. of Med., Kanagawa, Japan, 2DNA Chip Res. Inc., Tokyo, Japan, 3Natl. Ctr. for Child Hlth.and Dev., Tokyo, Japan

270 A NOVEL BIOMATERIAL FOR ARTICULAR CARTILAGE REPAIR GENERATED BY SELF-ASSEMBLY: A HISTOPATHOLOGICAL ANALYSIS FOR CARTILAGE TISSUE ENGINEERING USING A SELF-ASSEMBLED BIOMATERIAL IN RABBIT KNEE JOINTS.

K. Yudoh, T. Kumai, Sr., N. Yui, H. Fujiya; St. Marianna Univ. Sch. of Med., Kawasaki City, Japan

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271 RAAV SOX9 GENE TRANSFER STIMULATES THE CHONDROGENIC DIFFERENTIATION ACTIVITIES IN HUMAN PERIPHERAL BLOOD ASPIRATES J. K. Venkatesan, P. Orth, A. Rey-Rico, G. Schmitt, H. Madry, M. Cucchiarini; Saarland Univ., Homburg, Germany

272 NATURAL POLYMER-BASED HYDROGELS FOR CARTILAGE REGENERATION E. Montell, Sr.1, L. García-Fernández, Sr.2, A. Torrent, Sr.1, J. San Román, Sr.2; 1Pre-Clinical R&D Area, PharmaSci. Div., Bioibérica, Barcelona, Spain,

2Biomaterials Group, Inst. of Polymer Sci. and Technology (ICTP-CSIC) and CIBER’s Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Inst. de Salud Carlos III, Madrid, Spain

273 3’-SIALLYLACTOSE PROMOTES CARTILAGE REGENERATION BY EXTRACELLULAR MATRIX REMODELING C. Cho1,2, L-J. Kang2, J. Jeon1,2, S. Yang1,2; 1Dept. of BioMed. Sci., Ajou Univ. Graduate Sch. of Med., Suwon, Korea, Republic of, 2Dept. of Pharmacology, Ajou

Univ. Sch. of Med., Suwon, Korea, Republic of

274 PLATELET-RICH PLASMA TREATMENT IN PATIENTS WITH OSTEOARTHRITIS OF THE HIP AND GREATER TROCHANTERIC PAIN SYNDROME K. Shirokova, S. Noskov, L. Shirokova, V. Gorokhova; Yaroslavl State Med. Univ., Yaroslavl, Russian Federation

REGENERATIVE MEDICINE275 FIBRIN/HYALURONIC ACID HYDROGEL FOR COMBINED DELIVERY OF GAPMERS AND CHONDROCYTES AS A GENE THERAPY

APPROACH FOR OSTEOARTHRITIS J. Garcia1, J. Stein1, Y. Cai2, E. Wexselblatt3, L. Creemers1, J. Wengel4, K. Howard2, D. Saris1, A. Yayon3; 1UMC Utrecht, Utrecht, Netherlands, 2Interdisciplinary NanoSci.

Ctr. (iNANO), Aarhus Univ., Aarhus, Denmark, 3ProCore Biomed Ltd, Ness Ziona, Israel, 4Nucleic Acid Ctr., Univ. of Southern Denmark, Odense, Denmark

276 MODELLING AND PREDICTING THE LONG-TERM CLINICAL OUTCOME OF AUTOLOGOUS CHONDROCYTE IMPLANTATION J. H. Kuiper1,2, N. Dugard1,2, J. Parker1, P. Harrison1, C. G. Kuiper1, S. Roberts1,2, J. B. Richardson1,2; 1RJAH Orthopaedic Hosp., Oswestry, United Kingdom, 2ISTM,

Keele Univ., Keele, United Kingdom

277 WNT SIGNALLING IN MESENCHYMAL STEM CELLS IS HEIGHTENED IN RESPONSE TO PLASMA SPRAYED HYDROXYAPATITE COATINGS D. Kuntin1, N. Gosling2, D. Wood3, P. Genever1; 1Univ. of York, York, United Kingdom, 2DePuy Synthes, Leeds, United Kingdom, 3Univ. of Leeds, Leeds, United Kingdom

278 ASSESSING THE CHARACTERISTICS OF HUMAN MESENCHYMAL STROMAL CELLS DERIVED FROM BONE MARROW AND UMBILICAL CORD FOLLOWING EXPANSION IN THE QUANTUM® HOLLOW-FIBRE BIOREACTOR SYSTEM.

C. Mennan, S. Roberts, J. Garcia, C. Hulme, K. Wright; ISTM & Keele Univ., Oswestry, United Kingdom

279 IMMUNO-MODULATORY EFFECT OF VIRAL INTERLEUKIN 10 EXPRESSING MOUSE MESENCHYMAL STEM CELLS ON ACTIVATED IMMUNE CELLS. S. Raman, M. Murphy, P. Mancuso; Natl. Univ. of Ireland, Galway, Galway, Ireland

280 DEVELOPMENT OF FUNCTIONAL NANOPARTICLES FOR MSC-TARGETED JOINT REPAIR IN SITU M. Walker; The Univ. of York, YORK, United Kingdom

281 HUMORAL FACTORS PRODUCED BY POLYDACTYLY-DERIVED CHONDROCYTE SHEETS IN ARTICULAR CARTILAGE REPAIR T. Takahashi1, M. Sato1, E. Toyoda1, M. Maehara1, Y. Sogo1, A. Tominaga2, T. Takagi1, T. Akamatsu1, K. Okazaki2, M. Watanabe1; 1Tokai Univ. Sch. of Med., Kanagawa,

Japan, 2Tokyo Women’s Univ., Tokyo, Japan

282 MENSTRUAL BLOOD-DERIVED MESENCHYMAL STEM CELLS AS A POTENTIAL TOOL FOR CARTILAGE REGENERATION I. Uzieliene; State Res. Inst. Ctr. for Innovative Med., Vilnius, Lithuania

283 EXPLORING THE SOCIAL LIFE OF MESENCHYMAL STROMAL CELLS BY LABEL-FREE TRACKING OF INDIVIDUAL AND COLLECTIVE CELL BEHAVIOUR

A. L. Barnes1, J. O’Flaherty1, A. Carstairs1, S. Quick1, A. P. Stone1, R. Kasprowicz2, R. Suman3, P. G. Genever1; 1Univ. of York, York, United Kingdom, 2Phase Focus UK, Sheffield, United Kingdom, 3Phase Focus UK, York, United Kingdom

284 THE RNA BINDING PROTEIN HUR IS CRITICAL FOR EFFECTIVE DIFFERENTIATION OF BONE MARROW DERIVED STEM CELLS. B. T. McDermott, K. A. Johnson, H. F. Hayati, S. R. Tew; Univ. of Liverpool, Liverpool, United Kingdom

285 GENERATION OF OSTEOARTHRITIS AND HEALTHY MESENCHYMAL CELL LINES FOR RESEARCH ON REGENERATIVE MEDICINE FOR OSTEOARTHRITIS

M. PIÑEIRO-RAMIL, Sr.1, R. CASTRO-VIÑUELAS1, C. SANJURJO-RODRÍGUEZ1, T. HERMIDA-GÓMEZ2, I. FUENTES-BOQUETE1, J. DE TORO-SANTOS1, F. BLANCO-GARCÍA2, S. DÍAZ PRADO, Sr.1; 1UNIVERSIDADE DA CORUÑA, A CORUÑA, Spain, 2INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE A CORUÑA, A CORUÑA, Spain

43 | FINAL PROGRAM

286 DIFFERENTIAL EFFECTS OF MICROFRATURED ADIPOSE TISSUE COMPARED TO ISOLATED MESENCHYMAL STEM CELLS CO-CULTURED WITH OSTEOARTHRITIC SYNOVIOCYTES

F. Paolella1, C. Manferdini1, E. Gabusi1, L. Gambari2, G. Filardo3, E. Kon4, G. Lisignoli1; 1Lab. of Immunorheumatology and Tissue Regeneration, Rizzoli Orthopaedic Inst., Bologna, Italy, 2RAMSES Lab., Rizzoli Orthopaedic Inst., Bologna, Italy, 3NABI Lab., Rizzoli Orthopaedic Inst., Bologna, Italy, 4Humanitas Univ. Dept. of BioMed. Sci., Clinical and Res. Ctr., Rozzano (Milano), Italy

287 IDENTIFICATION OF BMP-7-MIMICKING PEPTIDES THAT REVERSE THE KATABOLIC-CHONDROCYTE PHENOTYPE IN OA CHONDROCYTES

M. Caron, E. Ripmeester, P. J. Emans, L. W. van Rhijn, T. Welting; MUMC+, Maastricht, Netherlands

288 HOW DOES CHONDROGENIC DIFFERENTIATION AND STIMULATION WITH INTERLEUKIN-1BETA AFFECT THE SECRETOME FROM BONE MARROW DERIVED MESENCHYMAL STEM CELLS

L. Bundgaard1,2, A. Stensballe3,4, K. J. Elbaek3,4, L. C. Berg1,2; 1Univ. of Copenhagen, Taastrup, Denmark, 2Dept. of Clinical Vet. Sci., Copenhagen, Denmark, 3Aalborg Univ., Aalborg, Denmark, 4Dept. of Hlth.Sci. and Technology, Aalborg, Denmark

289 PRIMARY CULTURE OF IL1-β- STIMULATED CHONDROCYTES SHOW BENEFICIAL EFFECTS OF CHILEAN PROPOLIS C. Arias1, D. S. Abdalla2, N. Saavedra1, M. Alvear1, K. Saavedra1, B. Vásquez1, M. del Sol1, L. A. Salazar1; 1Univ. de La Frontera, Temuco, Chile, 2Univ. de São Paulo,

São Paulo, Brazil

290 PULSED ELECTROMAGNETIC FIELDS ENHANCE METABOLIC ACTIVITY AND MYOTUBE FORMATION IN AN IN VITRO MODEL OF MYOBLASTS F. F. Masieri1, J. R. Schofield1, C. P. Velloso2,1, S. Setti3, R. Cadossi3, M. Abdel-Maguid1; 1Univ. of Suffolk, Ipswich, United Kingdom, 2King’s Coll. London, London,

United Kingdom, 3IGEA-Clinical Biophysics, Carpi (MO), Italy

291 MOLECULAR CHARACTERIZATION OF GENES INVOLVED IN CELL-TO-CELL COMMUNICATION DURING THE CHONDROGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STROMAL CELL

C. Rodríguez-Pereira1, M. Fernández-Moreno1,2, C. Guiance-Varela1, C. Ruiz-Romero1,2, F. J. Blanco1, J. Magalhaes1,2; 1Inst. of BioMed. Res. of A Coruña (INIBIC). CHUAC. SERGAS, A Coruña, Spain, 2Centro de Investigación Biomédica en Red (CIBER), Madrid, Spain

292 FATE OF ADIPOSE DDERIVED STEM CELLS IS CORREALTED WITH EXPRESSION OF SPECIFIC SET OF GENES A. A. Noor, Jr.; The Univ. of Lahore, Lahore, Pakistan

293 TARGETING THE OSTEOARTHRITIS VIA THE COMBINATION OF TCM Celastrol,NOVEL MODIFIED MIRNA AND RAPALOGUE Y. Zhang1,2, S. DAI1, K. MEGUELLATI3, Z. Zhang1; 1Dept. of Rheumatology,first clinical Coll. of Harbin Med. Univ., Harbin, China, 2Shenzhen Futian

Rheumatology Hosp., Shenzhen, China, 3Intl. lab, Dept..Chemistry,Jilin Univ., Changchun, China

294 INVESTIGATING THE ROLE OF CCCTC-BINDING FACTOR IN OSTEOARTHRITIS PATHOGENESIS A. Hijazi; Western Univ., London, ON, Canada

GENETICS, GENOMICS & EPIGENETICS 295 BROMODOMAIN INHIBITORS ARE POTENT EPIGENETIC REGULATORS OF CATABOLIC GENE EXPRESSION IN HUMAN OSTEOARTHRITIC

CHONDROCYTES M. C. de Andrés1, N. Madhusudan1, C. Bountra2, U. Oppermann2, R. O. Oreffo1; 1Univ. of Southampton. Faculty of Med., Southampton, United Kingdom, 2Univ.

of Oxford. Structural Genomic Consortium, Oxford, United Kingdom

296 GENOTYPE AT THE MGP OA RISK LOCUS CORRELATES WITH AN EXPRESSION QUANTITATIVE TRAIT LOCUS OPERATING ON MGP IN CARTILAGE AND WITH DNA METHYLATION AT A CLUSTER OF REGULATORY CpGs WITHIN ARHGDIB

C. Shepherd, L. N. Reynard, J. Loughlin; Newcastle Univ., Newcastle upon Tyne, United Kingdom

297 MODIFICATION OF THE SUPT3H/RUNX2-DMR USING CRISPR/Cas9 DEMONSTRATES FUNCTIONAL REGULATION OF RUNX2 EXPRESSION S. J. Rice, G. Aubourg, A. K. Sorial, M. Tselepi, D. Almarza, D. Deehan, L. N. Reynard, J. Loughlin; Newcastle Univ., Newcastle upon Tyne, United Kingdom

298 OSTEOARTHRITIS SUBTYPES SHOW DISTINGUISHED TRANSCRIPTOMIC LANDSCAPES. Y. F. Ramos, T. Sentner, R. Coutinho de Almeida, W. den Hollander, J. Meessen, E. Houtman, K. Heutink, N. Lakenberg, P. Slagboom, R. G. Nelissen, I.

Meulenbelt; Leiden Univ. Med. Ctr., Leiden, Netherlands

299 THE LONG NON-CODING RNA CASC20 IS A SUSCEPTIBILITY LOCUS FOR HETEROTOPIC OSSIFICATION: RESULTS OF A GENOME-WIDE ASSOCIATION STUDY

K. Hatzikotoulas1, M. J. Clark2, S. J. Macinnes2, E. Zeggini1, M. J. Wilkinson2; 1Wellcome Trust Sanger Inst., Cambridge, United Kingdom, 2Univ. of Sheffield, Sheffield, United Kingdom

44 | FINAL PROGRAM

300 MODELLING GENETIC MECHANISMS OF OSTEOARTHRITIS USING HUMAN INDUCED PLURIPOTENT STEM CELLS E. Cibrian Uhalte1, R. Fernando1, E. Zeggini1, L. Vallier1,2; 1Wellcome Trust Sanger Inst., Hinxton, United Kingdom, 2Univ. of Cambridge, Cambridge, United Kingdom

301 POLYMORPHIC VARIANTS IN ALDH1A2 DETERMINE THE EXPRESSION LEVEL OF ALDH1A2 AND CYP19A1 IN THE CARTILAGE OF PATIENTS UNDERGOING TRAPEZIECTOMY FOR SEVERE THUMB OSTEOARTHRITIS

L. Zhu1, A. Chanalaris1, K. Groves1, D. Furniss2, F. E. Watt1, M. Gardiner2, T. L. Vincent1; 1Kennedy Inst. of Rheumatology, Univ. of Oxford, Oxford, United Kingdom, 2Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sci.s, Univ. of Oxford, Oxford, United Kingdom

302 THE GENETIC ARCHITECTURE OF HIP STATISTICAL SHAPE MODELS SUGGESTS THAT ENDOCHONDRAL BONE FORMATION MAKES AN IMPORTANT CONTRIBUTION TO HIP SHAPE

D. Baird1, D. S. Evans2, J. S. Gregory3, F. R. Saunders3, C. V. Giuraniuc3, R. J. Barr3, R. M. Aspden3, F. K. Kamanu4, D. P. Kiel4, E. S. Orwoll5, S. R. Cummings2, N. E. Lane6, B. H. Mullins7, F. M. Williams7, B. Richards7, S. G. Wilson7, T. D. Spector7, B. G. Faber8, D. A. Lawlor1, T. J. Beck9, D. M. Evans10, L. Paternoster1, D. Karasik4, J. H. Tobias1; 1Univ. of Bristol, Bristol, United Kingdom, 2California Pacific Med. Ctr. Res. Insitute, San Franciso, CA, 3Univ. of Aberdeen, Aberdeen, United Kingdom, 4Harvard Med. Sch., Harvard, MA, 5Oregon Hlth.& Sci. Univ., Portland, OR, 6Univ. of California at Davis, Sacramento, CA, 7King’s Coll., London, United Kingdom, 8Univ. of Bristol, London, United Kingdom, 9Beck Radiological Innovations, Catonsville, MD, 10Univ. of Queensland, Brisbane, Australia

303 IDENTIFICATION OF DISTINCTIVE DNA METHYLATION PATTERNS CORRELATED WITH DIFFERENTIAL GENE EXPRESSION IN MURINE HYPERTROPHIC CHONDROCYTES IN VITRO.

P. Singh, S. Lessard, M. Otero; Hosp. for Special Surgery, NEW YORK, NY

304 GENOME-WIDE DNA METHYLATION STUDY OF HAND OSTEOARTHRITIS M. S. Yau1,2, R. Joehanes1, Y-H. Hsu1, D. P. Kiel1, D. T. Felson2,3; 1Inst. for Aging Res., Hebrew SeniorLife, Boston, MA, 2Boston Univ. Sch. of Med., Boston, MA,

3Univ. of Manchester, Manchester, United Kingdom

305 EZH2 INHIBITION REDUCES IL-1β-MEDIATED INFLAMMATION AND INCREASES ANABOLIC GENE EXPRESSION IN HUMAN CHONDROCYTES J. AURY-LANDAS, L. ALLAS, Q. ROCHOUX, S. LECLERCQ, K. BOUMEDIENE, C. BAUGE; BioConnecT - Université Caen Normandie, CAEN, France

306 A HYPERACTIVATING PROINFLAMMATORY RIPK2 ALLELE ASSOCIATED WITH EARLY-ONSET OSTEOARTHRITIS M. Jurynec, A. Sawitzke, T. Beals, B. Otterud, M. Redd, J. Stevens, M. Leppert, D. Grunwald; Univ. of Uath, Salt Lake City, UT

307 IDENTIFICATION OF A NEW CONSTITUTIONAL MUTATION OF COMP GENE ASSOCIATED WITH A CASE OF PRIMARY OSTEOARTHRITIS Q. Rochoux, C. Marcelli, S. Leclercq, K. BOUMEDIENE, C. Baugé, J. Aury-Landas; Univ. of Caen Normandy, CAEN, France

308 HUMAN TRANSMITOCHONDRIAL CYBRIDS. A USEFUL IN VITRO MODEL TO STUDY THE ROLE OF MITOCHONDRIA IN OSTEOARTHRITIS M. FERNANDEZ-MORENO1,2, A. DALAMAO-FERNANDEZ1, T. HERMIDA-GOMEZ1, I. REGO-PEREZ1, M. VAZQUEZ-MOSQUERA1, S. RELAÑO-

FERNANDEZ1, N. OREIRO-VILLAR1, C. FERNANDEZ-LOPEZ1, F. BLANCO-GARCIA1; 1INIBIC, LA CORUÑA, Spain, 2Centro de investigación biomédica en Red, Bioingenieria, Biomatereial y Nanomedicina CIBER-BBN, Madrid, Spain

309 A MICRORNA SCREEN REVEALS THE CRITICAL ROLE OF MICRORNA-23A-3P IN MAINTAINING CARTILAGE HOMEOSTASIS I. Prasadam, Sr., Y. Xiao, Sr.; Inst. of Hlth. and bioMed. Innovation, Queensland Univ. of Technology, Queensland, Australia

NONCODING RNAS310 CHARACTERISATION OF MICE LACKING MIR-140 AND ITS HOST GENE WWP2 Y. Hao, D. Tsompani, M. Radwan, S. Charlton, D. Young; Newcastle Univ., Newcastle upon Tyne, United Kingdom

311 A ROLE FOR SMALL NUCLEOLAR RNA HOST GENES IN CARTILAGE AGEING AND OSTEOARTHRITIS M. J. Peffers1, P. Balaska1, P. Dyers1, T. Welting2, A. Cremers3; 1Univ. of Liverpool, Neston, United Kingdom, 2Masstricht Med. Ctr., Maastricht, Netherlands,

3Maastricht Med. Ctr., Maastricht, Netherlands

312 THE DIFFERENTIAL EXPRESSION AND FUNCTIONAL ROLE OF LONG NON CODING RNAS IN INFLAMED SYNOVIAL TISSUE FROM PATIENTS WITH HIP OSTEOARTHRITIS

M. J. Pearson1, D. Nanus1, E. T. Davis2, M. A. Lindsay3, S. W. Jones1; 1Univ. of Birmingham, Birmingham, United Kingdom, 2Royal Orthopaedic Hosp., Birmingham, United Kingdom, 3Univ. of Bath, Bath, United Kingdom

313 THE ROLE OF MICRORNA 144 IN OSTEOARTHRITIS L. Le1, P. Ho1, I. Clark2; 1Hochiminh City Open Univ., Ho Chi Minh, Viet Nam, 2Sch. of Biological Sci., Norwich Res. Park, Univ. of East Anglia, UK, Norwich,

United Kingdom

45 | FINAL PROGRAM

314 THE ROLE OF MICRORNA 3085 IN CHONDROCYTES L. Le1,2, T. Swingler2, N. Crowe2, L. Niu2, T. Dalmay2, M. Barter3, D. Young3, S. Donell4, I. Clark2; 1Current address: Hochiminh City Open Univ., Ho Chi Minh, Viet

Nam, 2Sch. of Biological Sci., Norwich Res. Park, Univ. of East Anglia, UK, Norwich, United Kingdom, 3Inst. of Cellular Med., The Med. Sch., Newcastle Univ., Newcastle, United Kingdom, 4Inst. of Orthopaedics, Norfolk and Norwich Univ. Hosp., Norfolk, United Kingdom

315 INTEGRATIVE APPROACH UNCOVER MICRORNA INTERACTOME DYSREGULATION IN OSTEOARTHRITIS CARTILAGE R. C. Almeida1, Y. Ramos1, A. Mahfouz2,3, E. Houtman1, N. Lakenberg1, G. Kloppenburg4, P. Slagboom1, R. G. Nelissen5, M. Reinders1,2, I. Meulenbelt1; 1Dept.

of Molecular Epidemiology, Leiden Univ. Med. Ctr., Leiden, Netherlands, 2Delft Bioinformatics Lab, Delft Univ. of Technology, Delft, Netherlands, 3Leiden Computational Biology Ctr., Leiden Univ. Med. Ctr., Leiden, Netherlands, 4Dept. Rheumatology and Dept Clinical Epidemiology , Leiden Univ. Med. Ctr., Leiden, Netherlands, 5Dept. Orthopaedics, Leiden Univ. Med. Ctr., Leiden, Netherlands

316 HUMAN CHONDROCYTES WITH OXIDATIVE AND ER STRESS INHIBIT PROTEIN SYNTHESIS BY INDUCTION OF TRNA FRAGMENTS FROM A SUBSET OF TRNA ISOTYPES INDEPENDENT OF ANGIOGENIN EXPRESSION AND ACTIVITY.

J. Green, N. M. Khan, M. Y. Ansari, I. Ahmad, K. Novak, T. M. Haqqi; Northeast Ohio Med. Univ., Rootstown, OH

317 HYALURONAN-BASED HYDROGEL DELIVERING ANTIMIR-221 FOR THE GUIDANCE OF ENDOGENOUS CARTILAGE REPAIR A. Lolli1, K. Sivasubramaniyan1, M. L. Vainieri2, D. Eglin2, E. Wexselblatt3, A. Yayon3, S. Grad2, M. Alini2, G. J. van Osch1; 1Erasmus MC, Rotterdam, Netherlands,

2AO Res. Inst., Davos, Switzerland, 3ProCore Bio Med Ltd., Ness Ziona, Israel

318 MICRORNA-138 INHIBITS OSTEOGENESIS OF HUMAN DEDIFFERENTIATED CHONDROCYTES BY REGULATING RHOC AND THE ACTIN CYTOSKELETON

A. McAlinden1, H. Zheng1, D. Ramnaraign2, D. Simmons1, B. Anderson1, R. Nunley1; 1Washington Univ., St Louis, MO, 2Saint Louis Univ., St Louis, MO

319 SNORNA SIGNATURES IN CARTILAGE AGEING AND OSTEOARTHRITIS M. J. Peffers1, M. M. Caron2, A. Cremers2, D. A. Surtel2, Y. Fang3, P. Dyer3, P. Balaskas3, T. J. Welting2; 1Univ. of Liverpool, Neston, United Kingdom, 2Maastricht

Univ. Med. Ctr., Maastricht, Netherlands, 3Univ. of Liverpool, Liverpool, United Kingdom

320 MICRORNA-455 IS REGULATED IN A CIRCADIAN MANNER AND TARGETS A NUMBER OF COMPONENTS OF THE CIRCADIAN RHYTHM T. E. Swingler1, R. Horne1, Q. Meng2, I. M. Clark1; 1Univ. of East Anglia, Norwich, United Kingdom, 2Univ. of Manchester, Manchester, United Kingdom

321 THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME A. Smagul, S. Tew, M. J. Peffers; Univ. of Liverpool, Liverpool, United Kingdom

322 DEFINING THE ROLE AND MECHANISMS OF MICRORNAS IN CARTILAGE AGEING AND DISEASE P. Balaskas1, K. Goljanek-Whysall1, P. Clegg1, T. Welting2, M. Peffers1; 1Inst. of Ageing and Chronic Disease, Univ. of Liverpool, Liverpool, United Kingdom,

2Maastricht Univ. Med. Ctr.+, Maastricht, Netherlands

323 THE ROLE OF MICRORNAS IN TENDON DYSFUNCTION D. Bardell1, M. J. Peffers1, P. D. Clegg1, A. P. Molloy2, K. Goljanek-Whysall1; 1Univ. of Liverpool, Liverpool, United Kingdom, 2Univ. Hosp. Aintree, Liverpool,

United Kingdom

324 SPECIFIC METABOLIC ASSOCIATION BETWEEN OSTEOARTHRITIS AND TYPE 2 DIABETES REVEALED BY MASS SPECTROMETRY IMAGING M. R. EVEQUE1, P. J. EMANS2, T. J. WELTING2, A. BOONEN3, R. M. HEEREN1, B. CILLERO PASTOR1; 1M4I, Maastricht, Netherlands, 2Maastricht Univ.

Med. Ctr., Dept. of Orthopedic Surgery, Maastricht, Netherlands, 3Maastricht Univ. Med. Ctr., Caphri Res. Inst., Maastricht, Netherlands

PROTEOMICS & METABOLOMICS325 ACUTE PHASE RESPONSE SIGNALLING IS ALTERED FOLLOWING CARTILAGE HARVEST IN NON-RESPONDERS TO AUTOLOGOUS

CHONDROCYTE IMPLANTATION C. H. Hulme1, E. L. Wilson2, H. R. Fuller1, S. R. Roberts1, J. B. Richardson1, P. Gallacher3, M. J. Peffers4, S. L. Shirran5, C. H. Botting5, K. T. Wright1; 1Robert Jones

and Agnes Hunt Orthopaedic Hosp. (Keele Univ.), Oswestry, United Kingdom, 2Chester Med. Sch., Chester Univ., Chester, United Kingdom, 3Robert Jones and Agnes Hunt Orthopaedic Hosp., Oswestry, United Kingdom, 4Inst. of Ageing and Chronic Disease, Univ. of Liverpool, Liverpool, United Kingdom, 5BSRC Mass Spectrometry and Proteomics Facility, Univ. of St Andrews, St Andrews, United Kingdom

326 PROTEOMIC HETEROGENEITY OF SYNOVIAL BIOPSIES: COMPARISON BETWEEN OSTEOARTHRITIS, OSTEOARTHRITIS WITH CHONDROCALCINOSIS AND RHEUMATOID ARTHRITIS

D. de Seny1, D. Baiwir2, E. Bianchi3, C. Collin1, M. Deliège1, P. Delvenne3, E. Depauw4, J-P. Hauzeur1, M. Malaise1; 1Lab. of Rheumatology, GIGA Res., Univ. of Liège, CHU Liège, Liège, Belgium, 2GIGA Proteomic Facility, Univ. of Liège, CHU Liège, Liège, Belgium, 3Dept. of Pathology, CHU Liège, Liège, Belgium, 4Mass spectrometry platform, GIGA Res., Univ. of Liège, CHU Liège, Liège, Belgium

46 | FINAL PROGRAM

327 PROTEOMIC CHARACTERIZATION OF MINERALIZED TISSUES V. Tillgren, A. Aspberg, P. Onnerfjord; Clinical Sci., Lund, Sweden

328 IDENTIFYING LOAD RESPONSIVE SYNOVIAL FLUID METABOLIC MARKERS FOLLOWING PIVOT-SHIFT TESTING IN ACL INJURY SUBJECTS N. Khatib1, A. Papageorgiou1, S. Fairhurst1, C. Wilson2, D. J. Mason1; 1Cardiff Univ., Cardiff, United Kingdom, 2Cardiff & Vale Orthopaedic Ctr., Cardiff, United Kingdom

329 INVESTIGATION OF THE INTERLEUKIN 17 INDUCED CARTILAGE SECRETOME D. Sinkeviciute1,2, Y. He2, A. Aspberg1, A-C. Bay-Jensen2, P. Onnerfjord1; 1Lund Univ., Lund, Sweden, 2Nordic BioSci., Herlev, Denmark

330 LIPIDOMIC ANALYSIS OF HUMAN SERUM REVEALS ELEVATED PHOSPHO- AND SPHINGOLIPID SPECIES LEVELS DURING OSTEOARTHRITIS M. Kosinska1, G. Liebisch2, J. Wilhelm1, B. Ishaque1, M. Rickert1, J. Steinmeyer1; 1Justus Liebig Univ. Giessen, Giessen, Germany, 2Univ. Hosp. Regensburg,

Regensburg, Germany

331 COMBINED LC-QTOF-MS URINE METABOLOMICS AND 18F-NaF PET IMAGING INDICATES NOVEL COMPOUNDS ASSOCIATED WITH SPINE OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA

B. P. Norman1, L. F. Taylor1, A. S. Davison2, A. M. Milan2, G. A. Ross3, N. B. Roberts2, S. Vinjamuri4, L. R. Ranganath2, J. A. Gallagher1; 1Inst. of Ageing & Chronic Disease, Univ. of Liverpool, Liverpool, United Kingdom, 2Liverpool Clinical Lab., Royal Liverpool & Broadgreen Univ. Hosp. NHS Trust, Liverpool, United Kingdom, 3Agilent Technologies UK Ltd., Cheadle, Manchester, United Kingdom, 4Dept. of Nuclear Med., Royal Liverpool & Broadgreen Univ. Hosp. NHS Trust, Liverpool, United Kingdom

332 MITOCHONDRIAL CHANGES OF ARTICULAR CHONDROCYTES REVEALED BY OMICS ANALYSES B. Bakker1, G. Eijkel2, R. Mohren2, R. Heeren2, M. Karperien1, J. Post1, B. Cillero-Pastor2; 1Univ. of Twente, Enschede, Netherlands, 2Maastricht Univ., Maastricht, Netherlands

333 THE EFFECT OF EXERCISE ON THE PROTEIN PROFILE OF RAT KNEE JOINT INTRA- AND EXTRA-ARTICULAR LIGAMENTS Y. Ashraf Kharaz1, H. Birch2, E. Allchorne,3, A. Chester3, P. Clegg1, E. Comerford1,3; 1Univ. of Liverpool, Inst. of Ageing and Chronic Disease, Liverpool, United Kingdom,

2Univ. Coll. London, Inst. of Orthopaedics and Musculoskeletal Sci., London, United Kingdom, 3Univ. of Liverpool, Inst. of Vet. Sci., Neston, United Kingdom

334 STRATIFYING OSTEOARTHRITIS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY PROTEOMIC ANALYSIS OF SYNOVIAL FLUID

J. R. Anderson1, P. D. Clegg1, L. M. Rubio-Martinez2, C. M. Riggs3, M. J. Peffers1; 1Inst. of Ageing and Chronic Disease, Liverpool, United Kingdom, 2Inst. of Vet. Sci., Liverpool, United Kingdom, 3Hong Kong Jockey Club, Sha Tin, Hong Kong

335 METABOLOMICS AND METABOLIC FUNCTION ANALYSIS OF THE SECRETOME OF ARTICULAR CARTILAGE AND ISOLATED CHONDROCYTES IN RESPONSE TO PRO-INFLAMMATORY CYTOKINES

C. Fellows1,2, H. Quasnichka1,2, N. R. Chowdhury3, E. Budd1,2, D. J. Skene3, A. Mobasheri1,2; 1Faculty of Hlth.and Med. Sci., Univ. of Surrey, Guildford, United Kingdom, 2The D-BOARD European Consortium for Biomarker Discovery, Univ. of Surrey, Guildford, United Kingdom, 3Chronobiology, Faculty of Hlth.and Med. Sci., Univ. of Surrey, Guildford, United Kingdom

336 DISCOVERY METABOLOMICS AND LIPIDOMICS OF CANINE SYNOVIAL FLUID AND SERUM K. A. Overmyer1, P. Muir2, J. J. Coon1,2; 1Morgridge Inst. for Res., Madison, WI, 2Univ. of Wisconsin-Madison, Madison, WI

337 COMPREHENSIVE ANALYSIS OF A NEW CHEMICAL COMPOUND FOR THE TREATMENT OF OSTEOARTHRITIS BY PROTEOMIC APPROACH ON HUMAN CHONDROCYTES

S. Cheleschi1, V. Calamia2, M. Fernandez-Moreno3,4, M. Galeazzi1, M. Anzini5, A. Fioravanti1, F. J. Blanco2,3; 1Dept. of Med., Surgery and NeuroSci., Rheumatology unit, Azienda Ospedaliera Universitaria senese, Siena, Italy, 2Servicio de Reumatología, Grupo de Proteómica, INIBIC-Hospital Universitario A Coruña, Spain, 3Servicio de Reumatología Grupo de Genomica, INIBIC-Hospital Universitario A Coruña, Spain, 4Centro de Investigación Biomédica en Red, CIBER-BBM, A Coruña, Spain, 5Dept. of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy

338 MOLECULAR PHENOTYPES OF OSTEOARTHRITIS M. A. Kabalyk; Pacific State Med. Univ., Vladivostok, Russian Federation

339 ORAL HYDROLYZED TYPE 2 COLLAGEN PROTECTS AGAINST THE OA OF OBESITY AND MITIGATES OBESE GUT MICROBIOME DYSBIOSIS S. Soniwala1, K. I. Scinto1, E. M. Schott1, A. E. Stolarczyk1, D. A. Villani1, Q-A. Dar1, A. Grier1, J. P. Ketz1, S. R. Gill1, R. A. Mooney1, J. Prawitt2, M. J. Zuscik1; 1Univ.

of Rochester, Rochester, NY, 2Rousellot, Ghent, Belgium

47 | FINAL PROGRAM

MICROBIOME340 IDENTIFICATION OF A HUMAN CARTILAGE MICROBIOME AND CHARACTERIZATION OF DISTINCT MICROBIOME PROFILES ASSOCIATED

WITH OSTEOARTHRITIS. C. Dunn1,2, C. Velasco1,2, A. Rivas3, P. B. Jacob4, M. A. Jeffries1,2; 1Univ. of Oklahoma, Oklahoma City, OK, 2Oklahoma Med. Res. Fndn., Oklahoma City, OK,

3Univ. of Arkansas for Med. Sci., Little Rock, AR, 4Oklahoma Joint Reconstruction Inst., Oklahoma City, OK

341 THE ASSOCIATION OF PLASMA IL-1RA AND RELATED CYTOKINES WITH THE SEVERITY OF OSTEOARTHRITIS IN EARLY KNEE OSTEOARTHRITIS C. A. Ma1, J. Liu2, S. B. Wong3, S. N. Rajandran4, S. Xiong4, Y. Leung4; 1Duke-NUS Med. Sch., Singapore, Singapore, 2Ctr. for Quantitative Med., Duke-NUS

Med. Sch., Singapore, Singapore, 3Dept. of Diagnostic Radiology, Singapore Gen. Hosp., Singapore, Singapore, 4Dept. of Rheumatology and Immunology, Singapore Gen. Hosp., Singapore, Singapore

BIOMARKERS342 A BIOMARKER OF HYPERTROPHIC CHONDROCYTES, TYPE X COLLAGEN, COMPLETELY DISTINGUISHES BETWEEN OA AND RA Y. He1, T. Manon-Jensen1, L. Arendt-Nielsen2,3, K. K. Pedersen2,3, T. Christiansen4, J. Samuels5, S. Abramson5, M. K. Karsdal1, A. Mukundan5, A. C. Bay-Jensen1;

1Biomarkers and research, Nordic BioSci., Herlev, Denmark, 2SMI, Dept. of Hlth.Sci. and Technology, Faculty of Med., Aalborg Univ., Aalborg, Denmark, 3Ctr. for Sensory-Motor Interaction Sch. of Med., Aalborg Univ., Aalborg, Denmark, 4Orthopedic Dept., Gentofte Univ. Hosp., Hellerup, Denmark, 5Div. of Rheumatology, Dept. of Med., NYU Sch. of Med., New York, NY

343 PHARMACOKINETIC AND PHARMACODYNAMIC MODELLING OF THE NOVEL ANTI-ADAMTS-5 NANOBODY M6495 USING THE NEO-EPITOPE ARGS AS A BIOMARKER

J. Pereira1, I. Ottevaere2, B. Serruys2, E. Dejonckheere2, A-C. Bay-Jensen3, A-S. Siebuhr3, S. El Bawab1, C. Ladel1, S. Lindemann1; 1Merck KGaA, Darmstadt, Germany, 2Ablynx NV, Zwijnaarde, Belgium, 3Nordic BioSci., Herlev, Denmark

344 MECHANICALLY STIMULATED CS846 CORRELATES WITH ULTRASHORT ECHO TIME ENHANCED T2* QUANTITATIVE MRI AND GAIT MECHANICS 2 YEARS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION

M. R. Titchenal1,2, A. A. Williams1, J. L. Asay1,2, E. Migliore2, J. C. Erhart-Hledik1,2, T. P. Andriacchi1, C. R. Chu1,2; 1Stanford Univ., Stanford, CA, 2VA Palo Alto, Palo Alto, CA

345 POTENTIAL KEY BIOMARKERS OF OSTEOARTHRITIS BY INTEGRATIVE GENOME-WIDE GENE EXPRESSION PROFILING ANALYSIS R. Zhang1, Y. Wang2, A. Yang3,4, J. Zhang3, P. Yuan1, C. Shi1, Y. Xiong5; 1Shaanxi Univ. of Chinese Med., Xianyang, China, 2Dept. of Urology, Yangling Demonstration

Zone Hosp., Yangling, China, 3Sch. of Publ. Hlth., Brown Univ., Providence, 02906, RI, 4Lanzhou Univ., Lanzhou, China, 5Inst. of Endemic Diseases, Sch. of Publ. Hlth., Xi’an Jiaotong Univ. Hlth.Sci. Ctr., Key Lab. of Trace Elements and Endemic Diseases, Natl. Hlth.and Family Planning Commission, Xi’an, China

346 IN VITRO CHARACTERIZATION OF THE ADAMTS-5 SPECIFIC NANOBODY® M6495 D. Werkmann1, M-A. Buyse2, L. Dejager2, S. Cornelis2, C. S. Thudium3, M. A. Karsdal3, C. Ladel1, H. Guehring1, M. Michaelis1, S. Lindemann1; 1Merck KGaA,

Darmstadt, Germany, 2Ablynx, Zwijnaarde, Belgium, 3Nordic BioSci., Herlev, Denmark

347 SYNOVIAL FLUID FINGERPRINTING IN END-STAGE KNEE OSTEOARTHRITIS: A NOVEL BIOMARKER CONCEPT TO ASSESS DISEASE MODIFYING THERAPIES

C. Jayadev1, P. Hulley1, S. Snelling1, C. Swales1, G. Collins2, F. Germaschewski3, P. Taylor1, A. Price1; 1Nuffield Dept. of Orthopaedics, Rheumatology & Musculoskeletal Sci., Univ. of Oxford, Oxford, United Kingdom, 2Ctr. for Statistics in Med., Univ. of Oxford, Oxford, United Kingdom, 3GlaxoSmithKline Biopharmaceutical Res. & Dev., Stevenage, United Kingdom

348 SERUM CTX-II DOES NOT MEASURE THE SAME AS URINARY CTX-II Y. Luo, A. Bay-Jensen, M. Karsdala, P. Qvist, Y. He; Nordic BioSci. A/S, Herlev, Denmark

349 C1M, C2M, C3M, PRO-C2, AND CRPM IN SERUM REFLECT DIFFERENT POTENTIAL PATHOGENETIC DOMAINS OF OSTEOARTHRITIS, DATA FROM CHECK

A-C. Bay-Jensen1, M. A. Karsdal1, C. Ladel2, W. E. van Spil3; 1Rheumatology, Nordic BioSci., Biomarkers and Res., Herlev, Denmark, 2Merck KGaA, Darmstadt, Germany, 3Univ. Med. Ctr. Utrecht, Utrecht, Netherlands

350 THE ANTIOXIDATION PROTEIN α1-MICROGLOBULIN IS INCREASED IN SYNOVIAL FLUID EARLY AFTER KNEE INJURY AND IS ASSOCIATED WITH INTRA-ARTICULAR BLEEDING

S. Larsson1, B. Åkerström2, M. Gram2, L. S. Lohmander1, A. Struglics1; 1Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Lund, Sweden, 2Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Infection Med., Lund, Sweden

48 | FINAL PROGRAM

351 GLUCOSEPANE: A NEW BIOMARKER OF THE SEVERITY OF OSTEOARTHRITIS U. Ahmed1, C. Lambert2, C. Legrand2, A. Anwar1, K. Rajpoot3, S. Pasha1, R. Davidson4, I. Clark4, P. Thornalley1, N. Rabbani1, Y. Henrotin2; 1Univ. of Warwick,

Coventry, United Kingdom, 2Univ. of Liège, Liège, Belgium, 3Univ. of Birmingham, Birmingham, United Kingdom, 4Univ. of East Anglia, Norwich, United Kingdom

352 MEDIAL CARTILAGE SURFACE INTEGRITY AS A SURROGATE MEASURE FOR INCIDENT RADIOGRAPHIC AND CLINICAL KNEE OSTEOARTHRITIS FOLLOWING WEIGHT CHANGES

J. Runhaar1,2, E. Dam3,4, E. Oei1, S. Bierma-Zeinstra1,2; 1Erasmus MC Univ. Med. Ctr. Rotterdam, Rotterdam, Netherlands, 2D-BOARD Consortium, Rotterdam, Netherlands, 3Biomediq, Copenhagen, Denmark, 4Univ. of Copenhagen, Copenhagen, Denmark

353 ASSOCIATION OF CHEMERIN LEVELS IN SERUM AND SYNOVIAL FLUID WITH THE SEVERITY OF HIP OSTEOARTHRITIS. A. Philp, M. Pearson, M. O’Leary, S. Jones; Univ. of Birmingham, Birmingham, United Kingdom

354 NEXT GENERATION SEQUENCING DISCOVERS KNOWN AND NOVEL CIRCULATING MICRORNAS IN KNEE OSTEOARTHRITIS S. A. Ali, K. Shestopaloff, R. Gandhi, M. Kapoor; Univ. Hlth.Network, TORONTO, ON, Canada

355 SYNOVIAL CALPROTECTIN IS A USEFUL MARKER OF INFLAMMATION IN KNEE OSTEOARTHRITIS J. Calvet, C. Orellana, C. Galisteo, N. Navarro, J. Gratacós, M. Larrosa; Parc Taulí Sabadell Hosp. Univ.ri, Sabadell, Spain

356 A PROSPECTIVE STUDY OF SERUM CYTOKINE PROFILE IN INDIVIDUALS AT RISK OF POST-TRAUMATIC OSTEOARTHRITIS. G. Ren1, J. L. Whittaker2, C. A. Emery1, R. J. Krawetz1; 1Univ. of Calgary, Calgary, AB, Canada, 2Univ. of Alberta, Edmonton, AB, Canada

357 INFLAMMATION PREDICTS X-RAY PROGRESSION IN KNEE OSTEOARTHRITIS PATIENTS- A BIOMARKERS ANALYSIS OF THE DOXY COHORT Z. Huang1,2, J. Huebner2, E. Perry3, Y-J. Li3, B. Katz4, V. Kraus2,5; 1West China Med. Sch., SiChuan Univ., ChengDu, China, 2Duke Molecular Physiology Inst.,

Dept. of Med., Duke Univ. Sch. of Med., Durham, NC, 3Dept. of Biostatistics and Bioinformatics, Duke Univ. Med. Ctr., Durham, NC, 4Dept. of Biostatistics, Indiana Univ., Indianapolis, IN, 5Div. of Rheumatology, Dept. of Med., Duke Univ. of Med., Durham, NC

358 ASSOCIATION OF CIRCULATING MICRORNAS WITH PREVALENT AND INCIDENT OSTEOARTHRITIS IN WOMEN: THE OFELY STUDY. J-C. Rousseau1, M. Millet1, M. Crozet1, E. Sornay-Rendu1,2, O. Borel1,2, R. Chapurlat1,3; 1INSERM 1033, Lyon, France, 2Hôpital E. Herriot, Hospices Civils de

Lyon, Lyon, France, 3Hôpital E. Herriot, Hospices Civils de Lyon; Université de Lyon, Lyon, France

359 PATHWAY-BASED NETWORK ANALYSES AND CANDIDATE GENES ASSOCIATED WITH OSTEOARTHRITIS R. Zhang1, A. Yang2,3, J. Zhang2, P. Yuan1, J. Li1, B. Dong1, C. Shi1, Y. Xiong4; 1Shaanxi Univ. of Chinese Med., Xianyang, China, 2Sch. of Publ. Hlth., Brown Univ.,

Providence, 02906, RI, 3Lanzhou Univ., Lanzhou, China, 4Inst. of Endemic Diseases, Sch. of Publ. Hlth., Xi’an Jiaotong Univ. Hlth.Sci. Ctr., Key Lab. of Trace Elements and Endemic Diseases, Natl. Hlth.and Family Planning Commission, Xi’an, China

360 SUPEROXIDE DISMUTASE ACTIVITY IN HIP OSTEOARTHRITIC CARTILAGE SIGNIFICANTLY DECREASES IN AN AGE-INDEPENDENT MANNER M. Koike1, H. Nojiri1, H. Kanazawa1, K. Miyagawa1, H. Yamaguchi1, N. Nagura1, Y. Iwase1, H. Kurosawa1, K. Kaneko2; 1Dept. of Orthopaedics, Juntendo Koto

Geriatrics Med. Ctr., Tokyo, Japan, 2Dept. of Orthopaedics, Juntendo Univ., Tokyo, Japan

361 SMAD3 GENEPOLYMORPHISMS AND EXPRESSION IN SERUM AND CARTILAGEINFLUENCE THE RISK OFKNEE OSTEOARTHRITIS A. C. Sharma, Sr.1, R. N. SRIVASTAVA2, S. R. SRIVASTAVA2, S. RAJ3; 1King George’s Med. Univ., Lucknow, India, 2King George’s Med. Univ., LUCKNOW,

India, 3Westminster Coll., Salt Lake City, UT

362 COMPREHENSIVE EXPRESSION ANALYSIS OF SMALL NON CODING RNAS IN EARLY OSTEOARTHRITIS SYNOVIAL FLUID M. J. Peffers1, P. Balaska1, Y. Fang1, J. Anderson1, K. Burke1, T. Welting2; 1Univ. of Liverpool, Neston, United Kingdom, 2Maastricht Med. Ctr., Maastricht, Netherlands

363 THE ANTI-ADAMTS-5 NANOBODY®, M6495, PROTECTS AGAINST CARTILAGE BREAKDOWN IN CARTILAGE AND SYNOVIAL JOINT TISSUE EXPLANT MODELS

A. Siebuhr1, A-C. Bay-Jensen1, C. T. Thudium1, M. A. Karsdal1, B. Serruys2, D. Werkmann3, M. Michaelis3, C. Ladel3, S. Lindemann3; 1Nordic BioSci., Herlev, Denmark, 2Ablynx, Zwijnaarde, Belgium, 3Merck KGaA, Darmstadt, Germany

364 PATTERN OF SYNOVIAL FLUID CYTOKINE BIOMARKERS IN THE KNEE AFTER ANTERIOR CRUCIATE LIGAMENT TEAR SUGGESTS AN INITIAL REPAIR RESPONSE

M. F. Rai, L. Cai, N. Chinzei, O. Yousuf, F. Guilak, R. H. Brophy; Washington Univ., St. Louis, MO

365 A METHOD OF METABOLITE SIGNATURE SELECTION AND CLASSIFICATION MODELLING TO PREDICT KNEE OSTEOARTHITIS J. S. Rockel1, W. Zhang2,3, K. Shestopaloff1, S. Likhodii2, G. Sun2, A. Furey2, E. Randell2, K. Sundararajan1, R. Gandhi1,4, G. Zhai2,5, M. Kapoor1,4; 1Univ. Hlth.

Network, Toronto, ON, Canada, 2Mem. Univ. of Newfoundland, St. John’s, NL, Canada, 3Jilin Univ., Changchun, China, 4Univ. of Toronto, Toronto, ON, Canada, 5Univ. of Tasmania, Tasmania, Australia

49 | FINAL PROGRAM

366 IRISIN LEVELS ARE ASSOCIATED WITH EXERCISE LEVEL, PAIN AND FUNCTION IN PATIENTS WITH KNEE OSTEOARTHRITIS C. Orellana, J. Calvet, M. García-Manrique, N. Navarro, J. Gratacós, M. Larrosa; Parc Taulí Sabadell Hosp. Univ.ri, Sabadell, Spain

367 ADIPOKINES PRODUCTION IN METABOLIC-ASSOCIATED OSTEOARTHRITIS OF THE KNEE JOINT H. A. Haji Abd Kadir1, J. Alsousou2, M. M. Roebuck2, S. P. Frostick2; 1RIPAS Hosp., Bandar Seri Begawan, Brunei Darussalam, 2Univ. of Liverpool, Liverpool,

United Kingdom

368 KEY GENES AND PATHWAYS COMMON TO BOTH OA AND KBD R. Zhang1, A. Yang2,3, J. Zhang2, P. Yuan1, C. Shi1, Y. Xiong4; 1Shaanxi Univ. of Chinese Med., Xianyang, China, 2Sch. of Publ. Hlth., Brown Univ., Providence,

02906, RI, 3Lanzhou Univ., Lanzhou, China, 4Inst. of Endemic Diseases, Sch. of Publ. Hlth., Xi’an Jiaotong Univ. Hlth.Sci. Ctr., Key Lab. of Trace Elements and Endemic Diseases, Natl. Hlth.and Family Planning Commission, Xi’an, China

369 NOVEL BIOMARKERS FOR OSTEOARTHRITIS ARE LINKED TO PAIN SENSITIZATION, BONE MARROW LESIONS AND CARTILAGE DAMAGE L. Assi1, G. Whitley1, F. Howe1, N. Sofat1,2; 1St George’s, Univ. of London, London, United Kingdom, 2St George’s Univ. Hosp. NHS Fndn. Trust, London, United Kingdom

370 OPTICAL BIOMARKERS FOR THE EARLY DIAGNOSIS OF OSTEOARTHRITIS P. Casal Beiroa1, E. F. Burguera1,2, T. Hermida Gomez3,2, N. Goyanes4,2, N. Oreiro Villar3,2, F. J. Blanco1, P. Gonzalez5, J. Magalhaes1,2; 1Inst. of BioMed. Res. of

A Coruña (INIBIC). CHUAC. SERGAS., A Coruña, Spain, 2Centro de Investigación Biomédica en Red (CIBER), Madrid, Spain, 3Inst. of BioMed. Res. of A Coruña (INIBIC). CHUAC. SERGAS, A Coruña, Spain, 4Inst. of BioMed. Res. of A Coruña (INIBIC), A Coruña, Spain, 5Nuevos Materiales Group, Dept. of Applied Physics, Univ. of Vigo, Vigo, Spain

371 ASSESSMENT OF CANDIDATE PREDICTIVE PROTEIN BIOMARKERS FOR MICROFRACTURE AND OSTEOTOMY C. H. Hulme1, J. B. Richardson1, P. Gallacher1, S. R. Roberts2, K. T. Wright1; 1Robert Jones and Agnes Hunt Orthopaedic Hosp. (Keele Univ.), Oswestry, United

Kingdom, 2Robert Jones and Agnes Hunt Orthopaedic Hosp., Oswestry, United Kingdom

372 THE EFFECT OF SIMVASTATIN ON NOVEL EXPLORATORY BIOMARKERS OF CARTILAGE DEGRADATION H. Quasnichka1,2, E. Budd1,2, J. Tarlton3, S. Roberts4, C. Jackson5, B. Caterson6, A. Mobasheri1,2; 1Faculty of Hlth.and Med. Sci., Univ. of Surrey, Guildford, United

Kingdom, 2The D-BOARD European Consortium for Biomarker Discovery, Univ. of Surrey, Guildford, United Kingdom, 3Matrix Biology Group, Univ. of Bristol, Bristol, United Kingdom, 4Robert Jones & Agnes Hunt Orthopaedic Hosp., Keele Univ., Oswestry, United Kingdom, 5Bristol Heart Inst., Univ. of Bristol, Bristol, United Kingdom, 6Sch. of BioSci.s, Cardiff Univ., Cardiff, United Kingdom

373 OROSOMUCOID 2 SERVES FOR PREDICTING BUT NOT FOR MONITORING DRUG RESPONSE IN PATIENTS WITH KNEE OSTEOARTHRITIS TREATED WITH CHONDROITIN SULFATE/GLUCOSAMINE HYDROCHLORIDE

V. Calamia1, F. Picchi1, I. Rego-Pérez1, M. Camacho1, L. González1, P. Fernández-Puente1, M. Herrero2, H. Martínez2, C. Ruiz-Romero1, F. Blanco1; 1INIBIC-CHUAC, La Coruña, Spain, 2Bioiberica, SAU, Barcelona, Spain

374 A NEW METHOD FOR MULTIPLEX MEASUREMENTS OF BIOMARKERS IN SYNOVIAL FLUID ASPIRATES WITH HIGH SENSITIVITY AND EXTENSIVE QUALITY CONTROL

J. Hendriks1, D. Saris2, M. Karperien1; 1Univ. of Twente, Enschede, Netherlands, 2Univ. Med. Ctr. Utrecht, Utrecht, Netherlands

375 COLLAGEN BIOMARKER RESPONSES AND PAIN IN OBESE AND NON-OBESE INDIVIDUALS WITH KNEE OA AFTER RESISTANCE EXERCISE TRAINING

H. K. Vincent, K. R. Vincent; Univ. of Florida, Gainesville, FL

376 ARE ACYLCARNITINES NEW BIOMARKERS FOR OA? K. Tootsi, J. Kals, M. Zilmer, K. Paaptel, A. Märtson; Univ. of Tartu, Tartu, Estonia

377 NETWORK ANALYSES AND CANDIDATE GENES ASSOCIATED WITH KASHIN-BECK DISEASE R. Zhang1,2, Y. Xiong2, X. Yang2, A. Yang3,4, D. Zhang2, Z. Li2, B. Li2, C. Shi1, P. Yuan1; 1Shaanxi Univ. of Chinese Med., Xianyang, China, 2Inst. of Endemic Diseases,

Sch. of Publ. Hlth., Xi’an Jiaotong Univ. Hlth.Sci. Ctr., Key Lab. of Trace Elements and Endemic Diseases, Natl. Hlth.and Family Planning Commission, Xi’an, China, 3Sch. of Publ. Hlth., Brown Univ., Providence, 02906, RI, 4Lanzhou Univ., Lanzhou, China

378 DEGRADATION OF LUBRICIN BY CATHEPSIN G: A POTENTIAL MECHANISM FOR LUBRICIN DEGRADATION IN OSTEOARTHRITIS PATIENTS’SYNOVIAL FLUID

S. Huang1, K. Thomsson-Hulthe1, C. Jin1, A. Struglics2, S. Kalamajski3, T. A. Schmidt4, N. G. Karlsson1; 1Univ. of Gothenburg, Gothenburg, Sweden, 2Lund Univ., Lund, Sweden, 3Uppsala Univ., Uppsala, Sweden, 4Univ. of Connecticut, Farmington, CT

379 C-REACTIVE PROTEIN HAS NO CORRELATION WITH THE SEVERITY OF KNEE OSTEOARTHRITIS. A CROSS-SECTIONAL, OBSERVATIONAL STUDY F. B. Loures; INTO - Inst. Natl. de Traumatologia e Ortopedia, Rio de Janeiro, Brazil

50 | FINAL PROGRAM

380 URINARY BIOMARKERS TO NON-INVASIVELY EVALUATE HEALTH IN WILD MOOSE (ALCES ALCES) R. O. Peterson1, S. R. Hoy1, L. M. Vucetich1, J. A. Vucetich1, V. B. Kraus2, J. L. Huebner3; 1Michigan Technological Univ., Houghton, MI, 2Duke Univ., Durham, NJ,

3Duke Univ., Durham, NC

381 ARE SERUM CARTILAGE DEGENERATION BIOMARKER CONCENTRATIONS ACCURATE REPRESENTATIONS OF THE INTRA-ARTICULAR ENVIRONMENT OF THE KNEE?

E. R. Hunt1, C. Jacobs1, J. L. Huebner2, V. B. Kraus2, C. Lattermann1; 1Univ. of Kentucky, Lexington, KY, 2Duke Univ., Durham, NC

382 FREQUENCY OF OSTEOPHYTE FORMATION AT POSTERIOR NOTCH OF THE FEMUR AMONG HEALTHY KNEES OF 40’S AND 50’S T. SASHO, R. AKAGI, M. TAHARA, A. WATANABE, Y. OGAWA, S. KIMURA, A. SADAMASU, S. YAMAGUCHI; Chiba Univ., Chiba, Japan

EPIDEMIOLOGY 383 TOTAL JOINT REPLACEMENT (TJR) AS CLINICAL ENDPOINT IN OA; PREVALENCE AND INCIDENCE RATES OF TJRS FROM THE

PROSPECTIVE EPIDEMIOLOGIC RISK FACTOR (PERF I) STUDY A-C. Bay-Jensen1, C. Bager1,2, A. Bihlet1, C. Thudium1, I. Byrjalsen1, H. Nielsen2, J. Andersen1, B. J. Riis1, C. Christiansen1, M. A. Karsdal1; 1Nordic BioSci. A/S,

Herlev, Denmark, 2ProScion, Herlev, Denmark

384 THE ASSOCIATION OF BODY MASS INDEX GAIN, LOSS AND MAINTENANCE WITH THE DEVELOPMENT OF KNEE OSTEOARTHRITIS R. J. Cleveland1, L. Arbeeva1, L. M. Abbate2, C. Alvarez1, T. A. Schwartz1, J. B. Renner1, J. M. Jordan1, L. F. Callahan1; 1UNC Thurston Arthritis Res. Ctr., Chapel

Hill, NC, 2Univ. of Colorado, Denver, CO

385 POST-SURGICAL PREDICTORS OF CHRONIC PAIN AFTER PRIMARY KNEE REPLACEMENT S. Khalid1, R. Gooberman-Hill2, C. Garriga1, R. Pinedo-Villanueva1, N. Arden1, A. Price1, R. Middleton1, V. Wylde2, T. Peters2, A. Blom2, A. Judge2,1; 1Univ. of

Oxford, Oxford, United Kingdom, 2Univ. of Bristol, Bristol, United Kingdom

386 PREVALENCE AND INCIDENCE OF CLINICALLY DIAGNOSED KNEE, HIP AND HAND OSTEOARTHRITIS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: A NATIONAL REGISTER-BASED STUDY

M. T. Sanchez-Santos1,2, K. H. Rubin3, D. Glintborg3, M. S. Andersen3, S. Kluzek*4, B. Abrahamsen*3, BA and SK are joint senior authors; 1Univ. of Oxford, Oxford, United Kingdom, 2Arthritis Res. UK Sports Exercise and Osteoarthritis Ctr. of Excellence, Univ. of Oxford, Oxford, United Kingdom, 3Dept. of Endocrinology, Odense Univ. Hosp., Odense, Denmark, 4Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sci., Univ. of Oxford, Oxford, United Kingdom

387 IMPACT OF A NATIONAL ENHANCED RECOVERY PROGRAMME ON PATIENT OUTCOMES OF PRIMARY TOTAL AND UNICOMPARMENTAL KNEE REPLACEMENT: 2008-2016 ENGLAND TRENDS

C. Garriga1, A. Prats-Uribe1, A. Price1, D. Prieto-Alhambra1, A. Carr1, N. Arden1, J. Leal1, R. Gooberman-Hill2, C. Cooper3, G. Peat4, K. Baker1, A. Judge2; 1Univ. of Oxford, Oxford, United Kingdom, 2Univ. of Bristol, Bristol, United Kingdom, 3Univ. of Southampton, Southampton, United Kingdom, 4Univ. of Keele, Keele, United Kingdom

388 IMPACT OF THE PATELLOFEMORAL AND TIBIOFEMORAL PHENOTYPE ON 10-YEAR SYMPTOMATIC AND RADIOGRAPHIC PROGRESSION OF KNEE OSTEOARTHRITIS IN THE CHECK STUDY

M. van Middelkoop, D. Schiphof, S. M. Bierma-Zeinstra; Erasmus MC Med. Univ., Rotterdam, Netherlands

389 LONGITUDINAL VALIDITY OF USING DIGITAL PHOTOGRAPHSFOR ASSESSING PROGRESSION OF HAND OSTEOARTHRITIS OVER 7 YEARS IN COMMUNITY-DWELLING ADULTS

M. Marshall1, H. Jonsson2, G. P. Helgadottir3, E. Nicholls1, H. L. Myers1, V. Jansen4, D. van der Windt1; 1Keele Univ., Staffordshire, United Kingdom, 2Landspitalinn Univ. Hosp., Univ. of Iceland, Reykavik, Iceland, 3Univ. of Iceland, Reykavik, Iceland, 4Pulvertaft Hand Ctr., Royal Derby Hosp., Derby, United Kingdom

390 THE NEGLECT OF MUSCULOSKELETAL DISORDERS AND OSTEOARTHRITIS WITHIN THE BROADER PUBLISHED HEALTH LITERATURE - A BIBLIOMETRIC STUDY

A. V. Perruccio1, C. Yip2, J. Power3, M. Canizares3, E. M. Badley4; 1Hlth.care & Outcomes Res. and Arthritis Program, Krembil Res. Inst.; IHPME, Univ. of Toronto, Toronto, ON, Canada, 2Hlth.care & Outcomes Res., Krembil Res. Inst., Toronto, ON, Canada, 3Arthritis Program, Krembil Res. Inst., Toronto, ON, Canada, 4Hlth.care & Outcomes Res., Krembil Res. Inst.; Univ. of Toronto, Toronto, ON, Canada

391 DEVELOPMENT OF A PREDICTION MODEL FOR HIP REPLACEMENT AMONGST FORMER ELITE RUGBY PLAYERS M. A. Davies1,2, M. T. Sanchez-Santos2, K. A. Stokes1, S. P. Kemp3, J. L. Newton2, N. K. Arden2, A. D. Judge4,2; 1Univ. of Bath, Bath, United Kingdom, 2Univ. of

Oxford, Oxford, United Kingdom, 3Rugby Football Union, Twickenham, United Kingdom, 4Univ. of Bristol, Bristol, United Kingdom

392 BODY WEIGHT STATUS AND STATUS CHANGE OVER 5 YEARS AFTER ACL RUPTURE BY AGE, SEX, AND REGION: THE DELAWARE-OSLO COHORT L. M. Thoma1, D. K. White1, M. Risberg2, L. Snyder-Mackler1; 1Univ. of Delaware, Newark, DE, 2Norwegian Sch. of Sport Sci. and Div. of Orthopedic Surgery,

Oslo Univ. Hosp., Oslo, Norway

51 | FINAL PROGRAM

393 THE BURDEN FOR KNEE OSTEOARTHRITIS AMONG CHINESE ELDERLY: ESTIMATES FROM A NATIONAL REPRESENTATIVE STUDY Q. Liu1, Y. Zhang2, S. Wang1, J. Lin1; 1Peking Univ., Beijing, China, 2Harvard Med. Sch., Boston, MA

394 ASSOCIATION BETWEEN OBJECTIVELY ASSESSED PHYSICAL ACTIVITY MEASURES AND LONGITUDINAL KNEE STRUCTURAL DAMAGE H. Khan; Gosford Hosp., Gosford, Australia

395 FEMALE REPRODUCTIVE AND HORMONAL FACTORS AND INCIDENCE OF PRIMARY TOTAL KNEE ARTHROPLASTY DUE TO OSTEOARTHRITIS S. Hussain1, Y. Wang1, G. G. Giles2, S. Graves3, A. E. Wluka1, F. M. Cicuttini1; 1Monash Univ., Melbourne, Australia, 2Cancer Council Victoria, Melbourne,

Australia, 3Australian Orthopaedic Association Natl. Joint Replacement Registry, South Australia, Australia

396 COMORBID CONDITIONS AND THE TRANSITION AMONG STATES OF KNEE OSTEOARTHRITIS AND SYMPTOMS IN A COMMUNITY-BASED LONGITUDINAL STUDY: A MULTI-STATE MODEL APPROACH

C. Alvarez, R. J. Cleveland, T. A. Schwartz, J. B. Renner, L. Arbeeva, J. M. Jordan, L. F. Callahan; Univ. of North Carolina-Chapel Hill, Chapel Hill, NC

397 THE IMPACT OF PATIENT CHARACTERISTICS ON LIFETIME RISK OF REVISION FOLLOWING KNEE AND HIP REPLACEMENT: EVIDENCE FROM LINKED PRIMARY CARE AND HOSPITAL RECORDS

E. Burn1, N. K. Arden1,2, C. J. Edwards3, C. Cooper1,2, D. W. Murray1, D. Prieto-Alhambra1,4, R. Pinedo-Villanueva1,2; 1NDORMS, Univ. of Oxford, Oxford, United Kingdom, 2MRC Lifecourse Epidemiology Unit, Univ. of Southampton, Southampton, United Kingdom, 3NIHR Wellcome Trust Clinical Res. Facility, Univ. Hosp. Southampton, Southampton, United Kingdom, 4GREMPAL Res. Group, Idiap Jordi Gol and CIBERFes, Univ.t Autonoma de Barcelona and Inst. de Salud Carlos III, Barcelona, United Kingdom

398 IDENTIFYING PHYSICAL ACTIVITY PHENOTYPES AND THEIR ASSOCIATION WITH OSTEOARTHRITIS OUTCOMES OVER 10.7 YEARS I. Munugoda1, F. Pan1, K. Wills1, F. Cicuttini2, S. Graves3, M. Lorimer4, G. Jones1, M. Callisaya1, D. Aitken1; 1Menzies Inst. for Med. Res., Univ. of Tasmania, Hobart,

Australia, 2Dept. of Epidemiology and Preventive Med., Monash Univ. Med. Sch., Melbourne, Australia, 3Australian Orthopaedic Association Natl. Joint Replacement Registry (AOANJRR), Adelaide, South Australia, Australia, 4South Australian Hlth.and Med. Res. Inst. (SAHMRI), Adelaide, South Australia, Australia

399 A NOVEL ANALYSIS METHOD TO EXAMINE THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND LEG STRENGTH WITH KNEE CARTILAGE VOLUME LOSS OVER 10.7 YEARS

I. Munugoda1, S. Balogun1, K. Wills1, F. Cicuttini2, G. Jones1, M. Callisaya1, D. Aitken1; 1Menzies Inst. for Med. Res., Univ. of Tasmania, Hobart, Australia, 2Dept. of Epidemiology and Preventive Med., Monash Univ. Med. Sch., Melbourne, Australia

400 CHONDROCALCINOSIS OF THE KNEE AND THE RISK FOR KNEE OR HIP OSTEOARTHRITIS PROGRESSION: DATA FROM THE KHOALA COHORT. A. Latourte, Jr.1, A-C. Rat, Sr.2, W. Ngueyon Sime, Jr.2, C. Roux, Sr.3, F. Guillemin, Sr.2, P. Richette, Sr.1; 1Hôpital Lariboisière, Paris, France, 2CHRU Nancy,

Nancy, France, 3CHU Pasteur 2, Nice, France

401 THE EFFECT OF BODY MASS INDEX CHANGE ON INCREASED KELLGREN-LAWRENCE GRADE IN KNEE: A JOINT MODELING APPROACH L. Arbeeva1, R. J. Cleveland1, C. Alvarez1, T. A. Schwartz1, L. M. Abbate2, A. E. Nelson1, Y. M. Golightly1, J. B. Renner1, J. M. Jordan1, L. F. Callahan1; 1Univ. of North

Carolina-Chapel Hill, Chapel Hill, NC, 2Univ. of Colorado, Denver, CO

402 COMORBID CONDITIONS AND THE TRANSITION AMONG STATES OF HIP OSTEOARTHRITIS AND SYMPTOMS IN A COMMUNITY-BASED LONGITUDINAL STUDY: A MULTI-STATE MODEL APPROACH

C. Alvarez, R. J. Cleveland, T. A. Schwartz, J. B. Renner, L. Arbeeva, J. M. Jordan, L. F. Callahan; Univ. of North Carolina-Chapel Hill, Chapel Hill, NC

403 RADIOGRAPHIC OSTEOARTHRITIS AND JOINT REPLACEMENTS OF KNEES AND HIPS DURING 10-YEAR FOLLOW-UP IN CHECK M. van Middelkoop1, D. Schiphof1, J. Runhaar1, E. J. van Spil2, E. H. Waarsing1, S. M. Bierma-Zeinstra1; 1Erasmus MC Med. Univ., Rotterdam, Netherlands, 2UMC,

Utrecht, Netherlands

404 THE POPULATION BURDEN OF KNEE REPLACEMENT SURGERY AFTER SPORTS INJURY I. N. Ackerman1, M. A. Bohensky2, J. L. Kemp3, R. de Steiger2,4; 1Monash Univ., Melbourne, Australia, 2The Univ. of Melbourne, Melbourne, Australia, 3La Trobe

Univ., Melbourne, Australia, 4Epworth Hlth.Care, Melbourne, Australia

405 PRESENCE OF COMORBIDITIES AND PROGNOSIS OF CLINICAL SYMPTOMS IN KNEE AND/OR HIP OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

A. Van Ginckel, P. Calders; Ghent Univ., Ghent, Belgium

406 A PREDICTION MODEL FOR HAND OSTEOARTHRITIS IN MIDDLE-AGED MEN - DATA FROM THE SWEDISH CONSCRIPTION REGISTER K. Magnusson1,2, A. Turkiewicz1, S. Timpka3, M. Englund1,4; 1Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Clinical Epidemiology Unit,

Lund, Sweden, Lund, Sweden, 2Diakonhjemmet Hosp., Dept. of Rheumatology, Natl. Advisory Unit on Rehabilitation in Rheumatology, Oslo, Norway, Oslo, Norway, 3Genetic and Molecular Epidemiology, Lund Univ. Diabetes Ctr., Dept. of Clinical Sci. Malmö, Lund Univ., Malmö, Sweden, Lund, Sweden, 4Clinical Epidemiology Res. and Training Unit, Boston Univ. Sch. of Med., Boston, MA, USA, Boston, MA

52 | FINAL PROGRAM

407 WEATHER, AIR POLLUTION AND RHEUMATIC DISEASES: A PROSPECTIVE AND CORRELATIONAL STUDY OF INFLUENCE OF WEATHER AND AIR POLLUTION ON THE PERCEPTION OF JOINT PAIN IN PATIENTS WITH CHRONIC RHEUMATIC DISEASES

N. R. Ziade1,2, M. Bouzamel2, G. Abi Karam1,2, M. Mrad-Nakhle3, W. Farah2; 1Hotel-Dieu de France, Beirut, Lebanon, 2Saint-Joseph Univ., Beirut, Lebanon, 3Balamand Univ., Beirut, Lebanon

408 ASSOCIATIONS BETWEEN CIRCULATING S100A8/A9AND KNEE SYMPTOMS, JOINT CARTILAGE DEFECTS AND CARTILAGE BIOMARKERS IN PATIENTS WITH KNEE OSTEOARTHRITIS

G. Ruan1, J. Xu1, K. Wang1, J. Wu1, J. Ren1, B. Chang1, F. Bian1, Z. Zhu2, W. Han2, C. Ding1,3; 1the First Affiliated Hosp. of Anhui Med. Univ., Hefei, China, 2Zhujiang Hospit of Southern Med. Univ., Guangzhou, China, 3Menzies Inst. for Med. Res., Univ. of Tasmania, Hobart, Austria

409 INVESTIGATION OF SELF-REPORTED PAINFUL JOINT COUNT AS AN OUTCOME MEASURE IN HAND OSTEOARTHRITIS F. P. Kroon, J. L. van der Plas, S. van Beest, W. Damman, M. Kloppenburg; Leiden Univ. Med. Ctr., Leiden, Netherlands

410 THE ASSOCIATION BETWEEN SMOKING AND EARLY KNEE OSTEOARTHRITIS IN A COHORT OF DANISH PATIENTS UNDERGOING KNEE ARTHROSCOPY

M. B. Johnsen1,2, K. Pihl3, N. Nissen4, R. R. Sørensen5, U. Jørgensen6, M. Englund7, J. B. Thorlund3; 1Inst. of Clinical Med., Univ. of Oslo, Oslo, Norway, 2Res. and Communcation Unit for Musculoskeletal Hlth., Oslo Univ. Hosp., Oslo, Norway, 3Res. Unit for Musculoskeletal Function and Physiotherapy, Dept. of Sports Sci. and Clinical Biomechanics, Univ. of Southern Denmark, Odense, Denmark, 4Lillebaelt Hosp., Kolding, Denmark, 5Dept. of Orthopaedic Surgery, Lillebaelt Hosp., Vejle, Denmark, 6Odense Univ. Hosp., Odense, Denmark, 7Lund Univ., Faculty of Med., Dept. of Clinical Sci.-Lund Clinical, Orthopaedics Clinical Epidemiology Unit, Lund, Sweden

411 ASSOCIATION OF ABDOMINAL ADIPOSITY AND PREVALENT AND INCIDENT POLYARTICULAR OSTEOARTHRITIS C. B. Eaton1, J. B. Driban2, J. Davis2, L. F. Schaefer3, M. B. Roberts4, I. K. Haugen5, S. E. Smith3, J. Duryea3, L. Price6, B. Lu7, T. E. McAlindon2; 1Warren Alpert

Med. Sch. of Brown Univ., Providence, RI, 2Tufts Med. Ctr., Boston, MA, 3Dept. of Radiology, Brigham and Women’s Hosptial and Harvard Med. Sch., Boston, MA, 4Mem. Hosp. of Rhode Island, Pawtucket, RI, 5Dpeartment of Rheumatology, Diakonhjemmet Hosp., Oslo, Norway, 6Div. of Rheumatology, Tufts Med. Ctr., Boston, MA, 7Div. of Rheumatology, Immunology & Allergy, Brigham & Women’s Hosp. and Harvard Med. Sch., Boston, MA

412 OBJECTIVELY MEASURED ASPECTS OF SLEEP IN KNEE OSTEOARTHRITIS J. Lee1, R. Chang1, P. Semanik2, R. Jackson3, D. Dunlop1; 1Northwestern Univ. Feinberg Sch. of Med., Chicago, IL, 2Rush Univ., Chicago, IL, 3Ohio State Univ.,

Chicago, IL

413 PREDICTORS OF MULTI-SITE JOINT PAIN IN OLDER AUSTRALIAN WOMEN K. de Luca1, A. Wong2, A. Eklund3, M. Fernandez1, J. Byles4, M. Ferreira1, L. Parkinson5, J. Hartvigsen6; 1Univ. of Sydney, Sydney, Australia, 2The Hong Kong

Polytechnic Univ., Hong Kong, Hong Kong, 3Karolinska Inst.t, Stockholm, Sweden, 4Univ. of Newcastle, Newcastle, Australia, 5Central Queensland Univ., Rockhampton, Australia, 6Univ. of Southern Denmark, Odense, Denmark

414 OA AND SYMPTOMS COMPATIBLE WITH OA IN THE KNEE, HIP AND HAND: FINDINGS FROM THE CANADIAN LONGITUDINAL STUDY ON AGING E. M. Badley1, C. Yip2, M. Canizares3, J. Power3, A. V. Perruccio4; 1Hlth.care & Outcomes Res., Krembil Res. Inst.; Univ. of Toronto, Toronto, ON, Canada, 2Hlth.

care & Outcomes Res., Krembil Res. Inst., Toronto, ON, Canada, 3Arthritis Program, Krembil Res. Inst., Toronto, ON, Canada, 4Hlth.care & Outcomes Res. and Arthritis Program, Krembil Res. Inst.; IHPME, Univ. of Toronto, Toronto, ON, Canada

415 BIOMECHANICAL CHARACTERISTICS OF STAIR AMBULATION IN PATIENTS WITH KNEE OA: A SYSTEMATIC REVIEW WITH META-ANALYSIS TOWARD A BETTER DEFINITION OF CLINICAL HALLMARKS

H. Iijima1,2, K. Shimoura3, T. Aoyama3, M. Takahashi1; 1Dept. of System Design Engineering, Keio Univ., Yokohama, Japan, 2Japan Society for the Promotion of Sci., Tokyo, Japan, 3Dept. of Physical Therapy, Human Hlth.Sci., Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan

416 PREVALENCE AND FACTORS ASSOCIATED WITH SELF-REPORTED FATIGUE IN INDIVIDUALS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS: THE MOST STUDY

H. O. Fawole1,2, J. L. Riskowski1, A. Dell’Isola1, M. P. Steultjens1, S. F. Chastin1, M. C. Nevitt3, J. Torner4, C. E. Lewis5, D. T. Felson6; 1Glasgow Caledonian Univ., Glasgow, United Kingdom, 2Univ. of Benin, Benin-City, Edo State, Nigeria, 3Univ. of San Francisco, San Francisco, CA, 4Univ. of Iowa, Iowa City, IA, 5Univ. of Alabama, Birmingham, AL, 6Boston Univ. Sch. of Med., Boston, MA

417 BODY FAT DISTRIBUTION AND ITS ASSOCIATION WITH RISK OF INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS S. Li1, D. Misra1, M. Chen1, M. Nevitt2, J. Torner3, C. E. Lewis4, D. Felson1; 1Boston Univ. Sch. of Med., Boston, MA, 2UCSF Sch. of Med., San Francisco, CA,

3Univ. of Iowa Coll. of Publ. Hlth., Iowa City, IA, 4Univ. of Alabama at Birmingham, Birmingham, AL

418 RISK OF POST TRAUMATIC KNEE OSTEOARTHRITISAFTER TRAUMATIC KNEE INJURY IN DEPLOYED MILITARY SERVICE MEMBERS D. Rhon1, K. Perez2, S. Eskridge2; 1Brooke Army Med. Ctr., San Antonio, TX, 2Leidos, San Diego, CA

53 | FINAL PROGRAM

419 INCIDENCE AND RELATED RISK FACTORS OF RADIOGRAPHIC KNEE OSTEOARTHRITIS IN A CHINESE SUBURBAN AREA: SHUNYI OSTEOARTHRITIS STUDY

C. Lin1, X. Wu2, Q. Liu1, X. Cheng3, Y. Chen1, Y. Ke1, J. Lin1; 1Peking Univ. People’s Hosp., Beijing, China, 2Peking Univ. Hlth.Sci. Ctr., Beijing, China, 3Zezhou People’s Hosp., Jincheng City, Shanxi Province, China

420 PREDICTORS OF UPPER LEG MUSCLE STRENGTH OVER 2 AND 4 YEARS IN SUBJECTS WITH KNEE OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE

A. H. de Zwart1, M. van der Leeden2,3, L. D. Roorda1, M. van der Esch1, J. W. Twisk4, W. F. Lems1,5, J. Dekker6,7; 1Amsterdam Rehabilitation Res. Ctr. | Reade, Amsterdam, Netherlands, 2Amsterdam Rehabilitation Ctr. | Reade, Amsterdam, Netherlands, 3VU Univ. Med. Ctr. (VUmc), Dept. of Rehabilitation Med., Amsterdam Publ. Hlth.reseach Inst., Amsterdam, Netherlands, 4VU Univ. Med. Ctr., dept of Epidemiology and Biostatistics, Amsterdam Publ. Hlth.research Inst., Amsterdam, Netherlands, 5VU Univ. Med. Ctr. (VUmc), dept of Rheumatology, Amsterdam, Netherlands, 6VU Univ. Med. Ctr. (VUmc), dept. of Rehabilitation Med., Amsterdam Publ. Hlth.research Inst., Amsterdam, Netherlands, 7VU Univ. Med. Ctr. (VUmc), Dept of Psychiatry, Amsterdam, Netherlands

421 BASELINE CLINICAL PARAMETERS INSUFFICIENT TO PREDICT 5YEAR OSTEOARTHRITIS INCIDENCE IN CHECK COHORT J. Paul1, P. Gramme1, A-C. Hick2, A. Cornet2, T. Heleputte1, Y. Henrotin3; 1DNAlytics, Louvain-la-Neuve, Belgium, 2Artialis SA, Liège, Belgium, 3Univ. of Liège,

Liege, Belgium

422 SICK LEAVE AFTER SURGERY FOR THUMB CARPOMETACARPAL OSTEOARTHRITIS: A POPULATION-BASED STUDY I. Atroshi1, J. M. Wolf2, C. Zhou3, J. Karlsson4, M. Englund5; 1Dept. of Orthopedics Hässleholm-Kristianstad and Clinical Sci., Lund Univ., Lund, Sweden, 2Dept.

of Orthopedic Surgery, Univ. of Chicago Hosp., Chicago, IL, 3Clinical Epidemiological Unit, Orthopedics, Dept. of Clinical Sci., Lund Univ., Lund, Lund, Sweden, 4Dept. of Orthopaedics, Inst. of Clinical Sci., Sahlgrenska Academy, Gothenburg, Sweden, 5Clinical Epidemiological Unit, Orthopedics, Dept. of Clinical Sci., Lund Univ., Lund, Sweden

423 PRIORITIES FOR OSTEOARTHRITIS RESEARCH IN CHINA Y. Mei1, S. Guan1, H. Zhang1, X. Han1, C. Li1, F. Teng1, Z. Zhang1, D. Hunter2; 1the First Affiliated Hosp. of Harbin Med. Univ., Harbin, China, 2Royal North Shore

Hosp.,Univ. of Sydney, Sydney, Australia

424 OCCUPATIONS ASSOCIATED WITH EARLY ONSET OF OSTEOARTHRITIS, SEVERITY AND CLINICAL HAND OSTEOARTHRITIS IN A POPULATION OF ELEMENTARY WORKERS

M. Castano Betancourt, E. Marchi, Sr., M. Lipay; Faculdade de Med. de Jundiai, Jundiai, Brazil

425 RELEVANCE OF SARCOPENIA AND KNEE EXTENSOR MUSCLE STRENGTH IN THE MATSUDAI KNEE OSTEOARTHRITIS SURVEY. A. NAWATA1, G. Omori2, Y. KOGA3, K. Endoh2, N. Endo4; 1Niigata Univ. Graduate Sch. of Med. and Dental Sci., Saitama-ken, Japan, 2Niigata Univ. of Hlth.and

Welfare, Niigata-ken, Japan, 3Nioji-Onsen Hosp., Niigata-ken, Japan, 4Niigata Univ. Graduate Sch. of Med. and Dental Sci., Niigata-ken, Japan

426 CLINICAL CHARACTERISTICS OF PATIENTS WITH TYPE 2 DIABETES MELLITUS AND SEVERE OSTEOARTHRITIS. A. Na, L. Jansky, Z. Gugala; Univ. of Texas Med. Branch, Galveston, TX

427 PROXIMAL GAIT ADAPTATIONS IN INDIVIDUALS WITH MEDIAL KNEE OA: A SYSTEMATIC REVIEW WITH META-ANALYSIS H. Iijima1,2, M. Takahashi1; 1Dept. of System Design Engineering, Keio Univ., Yokohama, Japan, 2Japan Society for the Promotion of Sci., Tokyo, Japan

428 PREVALENCE OF OSTEOARTHRITIS IN HIGH ALTITUDE AREA OF TIBET Z. Zhang1, Y. Liang1, Y. Mei1, W. Sun1, W. Wang1, X. Gong2, Z. Li3, J. Tang4; 1the first affiliated Hosp. of Harbin Med. Univ., Harbin, China, 2the first Hosp. of

Qiqihar, Qiqihar, China, 3the first affiliated Hosp. of Bengbu Med. Coll., Bengbu, China, 4Shanghai Tong ji Hosp., Shanghai, China

429 EARLY KNEE OSTEOARTHRITIS OR HEALTHY AGEING? K. Magnusson1,2, J. Kumm3, A. Turkiewicz1, M. Englund1,4; 1Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Clinical Epidemiology Unit,

Lund, Sweden, Lund, Sweden, 2Diakonhjemmet Hosp., Dept. of Rheumatology, Natl. Advisory Unit on Rehabilitation in Rheumatology, Oslo, Norway, Oslo, Norway, 3Dept. of Radiology, Univ. of Tartu, Tartu, Estonia, Tartu, Estonia, 4Clinical Epidemiology Res. and Training Unit, Boston Univ. Sch. of Med., Boston, MA, USA, Boston, MA

430 SUBJECTS WITH DIABETES MELLITUS HAVE HIGHER PREVALENCE, INCIDENCE AND PROGRESSION OF KNEE OSTEOARTHRITIS ASSESSED OVER 8 YEARS: DATA FROM THE OSTEOARTHRITIS INITIATIVE

S. C. Foreman1, J. Neumann1, G. B. Joseph1, M. C. Nevitt2, F. Liu2, J. A. Lynch2, C. E. McCulloch2, T. M. Link1; 1Dept. of Radiology and BioMed. Imaging, UCSF, San Francisco, CA, 2Dept. of Epidemiology and Biostatistics, UCSF, San Francisco, CA

431 RELATION OF RADIOGRAPHIC SEVERITY OF KNEE OSTEOARTHRITIS TO CLINICAL PAIN SCORES: RESULTS FROM THE PAIN PERCEPTION IN OSTEOARTHRITIS STUDY

L. Assi1, A. Harrison1, A. Kuttapitiya1, F. Howe1, V. Ejindu2, C. Heron2, G. Whitley1, N. Sofat1; 1St George’s, Univ. of London, London, United Kingdom, 2St George’s Univ. Hosp. NHS Fndn. Trust, London, United Kingdom

54 | FINAL PROGRAM

432 PREDICTIVE VALUE OF EARLY OSTEOARTHRITIC/DEGENERATIVE CHANGES ON RADIOGRAPHY AND MRI FOR INCIDENT CLINICAL AND RADIOGRAPHIC KNEE OA IN OVERWEIGHT AND OBESE WOMEN

J. Runhaar1,2, C. Bijen1, H. Rijkels-Otters1, E. Oei1, S. Bierma-Zeinstra1,2; 1Erasmus MC Univ. Med. Ctr. Rotterdam, Rotterdam, Netherlands, 2D-BOARD Consortium, Rotterdam, Netherlands

433 SERUM URIC ACID LEVELS INFLUENCE OSTEOARTHRITIS KNEE IN NON-GOUT POPULATION: DOES REFERENCE RANGE NEED A REVISIT? S. R. SRIVASTAVA, R. N. SRIVASTAVA, A. C. SHARMA, S. RAJ; KING GEORGE’S Med. Univ., LUCKNOW, India

434 RISK OF ISCHEMIC STROKE ASSOCIATED TO ANALGESIC DRUGS USE: A REAL WORLD DATA CASE-CONTROL STUDY R. Vives1,2, A. Gomez-Lumbreras3, M. Fradera1, M. Giner-Soriano3,4, A. Garcia-Sangenis3, J. Marsal3, R. Morros3,2; 1Corporació Sanitaria Parc Taulí, Sabadell,

Barcelona, Spain, 2Univ.t Autònoma de Barcelona, Barcelona, Spain, 3IDIAP Jordi Gol, Barcelona, Spain, 4Inst. Català de la Salut, Barcelona, Spain

435 THE IMPACT OF OCCUPATIONAL EXPOSURE ON PAIN AND FUNCTION IN PERSONS WITH BASE OF THUMB OSTEOARTHRITIS. V. Duong, J. P. Eyles, L. A. Deveza, S. R. Robbins, D. J. Hunter; Univ. of Sydney, St Leonards, Australia

OA: CLINICAL ASPECTS & OUTCOMES436 DIABETICS SHOW ACCELERATED PROGRESSION OF CARTILAGE AND MENISCAL LESIONS: DATA FROM THE OSTEOARTHRITIS INITIATIVE J. Neumann1, J. B. Guimaraes2, U. Heilmeier1, G. B. Joseph1, F. C. Hofmann1, A. S. Gersing1,3, B. J. Schwaiger1,3, M. C. Nevitt4, C. E. McCulloch4, N. E. Lane5, J.

A. Lynch4, T. M. Link1; 1UCSF Dept. of Radiology & BioMed. Imaging, San Francisco, CA, 2UNIFESP Dept. Dept. of Radiology, Federal Univ. of Sao Paulo, Sao Paulo, Brazil, 3Dept. of Diagnostic and Interventional Radiology, Technical Univ. of Munich, Munich, Germany, 4UCSF Dept. of Epidemiology and Biostatistics, San Francisco, CA, 5UC Davis Dept. of Med. and Ctr. for Musculoskeletal Hlth., Sacramento, CA

437 HIGH INTENSITY PHYSICAL ACTIVITY IMPROVED BLOOD PRESSURE OF PATIENTS WITH KNEE OA M. U. Rezende1, J. M. Silva2, E. G. Ciolac2; 1Faculdade Med. USP, Sao Paulo, Brazil, 2São Paulo State Univ. (UNESP), Sao Paulo, Brazil

438 QUADRICEPS STRENGTH IN INDIVIDUALS WITH COEXISTING MEDIAL AND LATERAL OSTEOARTHRITIS: TOWARD AN IDENTIFICATION OF MODIFIABLE RISK FACTORS IN IMPORTANT SUBGROUP OF MILD RADIOGRAPHIC DISEASE

H. Iijima1,2, Y. Suzuki3, T. Aoyama3, M. Takahashi1; 1Dept. of System Design Engineering, Keio Univ., Yokohama, Japan, 2Japan Society for the Promotion of Scienc, Tokyo, Japan, 3Dept. of Physical Therapy, Human Hlth.Sci., Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan

439 ADULTS WITH INCIDENT ACCELERATED KNEE OSTEOARTHRITIS ARE MORE LIKELY TO RECEIVE A KNEE REPLACEMENT: DATA FROM THE OSTEOARTHRITIS INITIATIVE

J. B. Driban1, J. E. Davis1, S-H. Liu2, K. L. Lapane2, M. Harkey1, L. L. Price1,3, B. Lu4, G. H. Lo5,6, C. B. Eaton7, M. F. Barbe8, T. E. McAlindon1; 1Tufts Med. Ctr., Boston, MA, 2Univ. of Massachusetts Med. Sch., Worcester, MA, 3Tufts Univ., Boston, MA, 4Brigham & Women’s Hosp. and Harvard Med. Sch., Boston, MA, 5Houston Hlth.Services Res. and Dev. (HSR&D) Ctr. of Excellence Michael E. DeBakey VAMC, Houston, TX, 6Baylor Coll. of Med., Houston, TX, 7Alpert Med. Sch. of Brown Univ., Pawtucket, RI, 8Temple Univ. Sch. of Med., Philadelphia, PA

440 DOES KNEE EXTENSOR WEAKNESS INCREASE RISK OF WORSENING TIBIOFEMORAL AND PATELLOFEMORAL CARTILAGE DAMAGE? THE MOST STUDY

A. G. Culvenor1,2, N. Segal3, A. Guermazi4, F. Roemer5, D. Felson6, M. Nevitt7, C. Lewis8, J. J. Stefanik9; 1Paracelsus Med. Univ., Salzburg, Austria, 2La Trobe Univ., Melbourne, Australia, 3Univ. of Kansas, Kansas, KS, 4Boston Univ. Sch. of Med., Boston, MA, 5Univ. of Erlangen-Nuremberg, Erlangen, Germany, 6Bostn Univ. Sch. of Med., Boston, MA, 7UCSF, San Francisco, CA, 8Univ. of Alabama at Birmingham, Birmingham, AL, 9Univ. of Delaware, Newark, DE

441 CHANGE IN RADIOGRAPHIC KNEE OA SEVERITY CORRELATES BETTER WITH CHANGE IN COMPOSITE PAIN AND ACTIVITY KNEE SCORE COMPARED WITH PAIN ALONE SCORE

G. Lo1, J. Song2, T. E. McAlindon3, G. A. Hawker4, J. B. Driban3, L. Price3, C. B. Eaton5, M. C. Hochberg6, R. D. Jackson7, C. Kwoh8, M. C. Nevitt9, D. D. Dunlop2; 1Baylor Coll. of Med., Houston, TX, 2Northwestern Feinberg Sch. of Med., Chicago, IL, 3Tufts Med. Ctr., Boston, MA, 4Univ. of Toronto, Toronto, ON, Canada, 5Alpert Med. Sch. of Brown Univ., Pawtucket, RI, 6Univ. of Maryland, Baltimore, MD, 7The Ohio State Univ., Columbus, OH, 8Univ. of Arizona, Tucson, AZ, 9Univ. of California San Francisco, San Francisco, CA

442 TRIAMCINOLONE ACETONIDE EXTENDED-RELEASE INJECTABLE SUSPENSION (TA-ER) IS ASSOCIATED WITH REDUCED BLOOD GLUCOSE ELEVATION VS. STANDARD TRIAMCINOLONE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED, BLINDED, PARALLEL-GROUP STUDY

P. G. Conaghan1, S. J. Russell2, R. Sala3, G. Habib4, Q. Vo5, R. Manning6, A. Kivitz7, Y. Davis8, J. Lufkin9, J. R. Johnson10, S. Kelley9; 1Leeds Inst. of Rheumatic and Musculoskeletal Med., Univ. of Leeds and NIHR Leeds BioMed. Res. Ctr., Leeds, United Kingdom, 2Massachusetts Gen. Hosp. Diabetes Res. Ctr., Boston, MA, 3Dexcom, Inc., Sykesville, MD, 4Laniado Hosp. and Technion, Kiryat Sanz, Netanya, Israel, 5Dream Team Clinical Res., Anaheim, CA, 6PMG Res. of Knoxville, Knoxville, TN, 7Altoona Ctr. for Clinical Res., Duncansville, PA, 8Coastal Carolina Res. Ctr., Mt. Pleasant, SC, 9Flexion Therapeutics, Inc., Burlington, MA, 10Summit Analytical, Denver, CO

55 | FINAL PROGRAM

443 STEPPED CARE APPROACH FOR MEDIAL TIBIOFEMORAL OSTEOARTHRITIS (STREAMLINE) L. Melo1,2, S. R. Robbins1,2, H. Urban1,3, L. A. Deveza1,2, R. Asher4, V. L. Johnson2, L. Lawler5, D. Hunter6,2; 1The Univ. of Sydney Northern Clinical Sch., St

Leonards, Australia, 2Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., St Leonards, Australia, 3Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., St. Leonards, Australia, 4NHMRC Clinical Trials Ctr., Univ. of Sydney, St Leonards, Australia, 5Prima Hlth.Solutions Pty Ltd, Brookvale, Australia, 6The Univ. of Sydney Northern Clinical Sch., St. Leonards, Australia

444 A CLINICAL ASSESSMENT TOOL TO IMPROVE THE USE OF PAIN RELIEVING TREATMENTS IN KNEE OSTEOARTHRITIS. K. Akin-Akinyosoye1, N. Frowd1, L. Marshall1, J. Stocks1, G. S. Fernandes1,2, A. Valdes1, D. F. McWilliams1,3, W. Zhang1,3, M. Doherty1,3, E. Ferguson1,4, D. Walsh1,3;

1Arthritis Res. UK Pain Ctr., Div. of Rheumatology, Orthopaedics, and Dermatology, Sch. of Med., Univ. of Nottingham, Nottingham, United Kingdom, 2Arthritis Res. UK Ctr. for Sports, Exercise, and Osteoarthritis, Nottingham, United Kingdom, 3NIHR Nottingham BioMed. Res. Ctr., Nottingham, United Kingdom, 4Sch. of Psychology, Univ. of Nottingham, Nottingham, United Kingdom

445 IS FRAILTY ASSOCIATED WITH ADVERSE EVENTS AFTER TOTAL JOINT ARTHROPLASTY? L. A. Mandl1,2, A. M. Schmucker1,3, N. Hupert2, M. Sasaki1, J. Do1, C. N. Cornell1,2, M. B. Cross1,2, A. Gonzalez Della Valle1,2, M. P. Figgie1,2, S. A. Jerabek1,2, J.

Szymonifka1, S. K. Magid1,2; 1Hosp. for Special Surgery, New York, NY, 2Weill Cornell Med., New York, NY, 3Sidney Kimmel Med. Coll., Philadelphia, PA

446 TRIAMCINOLONE ACETONIDE EXTENDED-RELEASE INJECTABLE SUSPENSION (TA-ER) PROVIDES CLINICALLY RELEVANT IMPROVEMENTS IN PAIN AND FUNCTION OF KNEE OSTEOARTHRITIS: A POOLED ANALYSIS OF 3 RANDOMIZED CLINICAL TRIALS EMPLOYING COMPOSITE ASSESSMENTS

N. P. Katz1, P. G. Conaghan2, V. B. Kraus3, J. Lufkin4, J. R. Johnson5, S. Kelley4; 1Analgesic Solutions; Tufts Univ. Sch. of Med., Natick; Boston, MA, 2Leeds Inst. of Rheumatic and Musculoskeletal Med., Univ. of Leeds & NIHR Leeds BioMed. Res. Ctr., Leeds, United Kingdom, 3Duke Univ. Sch. of Med., Durham, NC, 4Flexion Therapeutics, Inc., Burlington, MA, 5Summit Analytical, Denver, CO

447 ASSOCIATION OF METABOLIC SYNDROME WITH KNEE AND HAND OSTEOARTHRITIS: A COMMUNITY-BASED STUDY OF WOMEN M. T. Sanchez-Santos1,2, A. Judge3,1, M. Gulati1, T. D. Spector4, D. J. Hart4, J. L. Newton1, N. K. Arden*1,2, S. Kluzek*1, *SK and NKA are joint senior authors;

1Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sci., Univ. of Oxford, Oxford, United Kingdom, 2Arthritis Res. UK Sports Exercise and Osteoarthritis Ctr. of Excellence, Oxford, United Kingdom, 3Musculoskeletal Res. Unit, Translational Hlth.Sci., Univ. of Bristol, Southmead Hosp., Bristol, United Kingdom, 4Dept. of Twin Res. & Genetic Epidemiology, King’s Coll. London, London, United Kingdom

448 MRI CARTILAGE THICKNESS AND KL GRADES SHOW DIFFERENT ASSOCIATIONS WITH OSTEOARTHRITIS PAIN: A STUDY USING ACCURATE 3D MRI DATA FROM 9,592 NORMAL AND OSTEOARTHRITIC KNEES IN THE OAI

O. A. Alabas1, M. A. Bowes2, E. M. Hensor1, G. Guillard2, A. Brett2, S. R. Kingsbury1, P. G. Conaghan1; 1Univ. of Leeds, Leeds, United Kingdom, 2Imorphics, Manchester, United Kingdom

449 RELATIONSHIP OF SLEEP AND FATIGUE TO HIP OSTEOARTHRITIS PAIN EXACERBATIONS: AN INTERNET-BASED CASE-CROSSOVER STUDY K. Fu1, J. Makovey1, B. Metcalf2, K. Bennell2, Y. Zhang3, R. Asher1, S. Robbins1, L. Deveza1, D. Hunter1; 1Univ. of Sydney, Sydney, Australia, 2Univ. of Melbourne,

Melbourne, Australia, 3Harvard Sch. of Med., Boston, MA

450 DOES THE PATIENT ACTIVATION MEASURE PROVIDE A MEANINGFUL MEASURE OF OA SELF-MANAGEMENT? J. P. Eyles1,2, M. Ferreira1,2, K. Mills3, B. R. Lucas1,4, S. R. Robbins1,2, M. Williams4, H. Lee5, S. Appleton6, D. J. Hunter1,2; 1Inst. of Bone & Joint Res., Kolling

Inst., Univ. of Sydney, Sydney, Australia, 2Rheumatology Dept, Royal North Shore Hosp., Sydney, Australia, 3Faculty of Med. and Hlth.Sci., Macquarie Univ., Sydney, Australia, 4Physiotherapy Dept, Royal North Shore Hosp., Sydney, Australia, 5Rehabilitation Dept, Hunters Hill Private Hopsital, Sydney, Australia, 6Physiotherapy Dept, Mount Wilga Private Hosp., Sydney, Australia

451 MOBILITY AND MUSCULAR POWER OF LOWER LIMBS IN ELDERLIES WITHOUT KNEE PAIN WITH KELLGREN-LAWRENCE (K/L) GRADE 3 OF KNEE OSTEOARTHRITIS (OA) WERE INFERIOR TO THOSE IN ELDERLIES WITHOUT KNEE PAIN WITH K/L GRADE 2 OF KNEE OA -A POPULATION-BASED COHORT STUDY “SPORTOLOGY CORE STUDY 2”

L. Liu1,2, M. Ishijima1,2, H. Kaneko1, S. Hada1, H. Arita1, T. Aoki2, Y. Negishi1, M. Momoeda1, Y. Someya2, Y. Tamura2,3, H. Watada2,3, R. Kawamori2,3, K. Kaneko1,2; 1Dept. of Med. for Orthopaedics and Motor Organ, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 2Sportology Ctr., Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 3Dept. of Metabolism & Endocrinology, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan

452 A MACHINE LEARNING APPROACH TO KNEE OA PHENOTYPING A. E. Nelson, F. Fang, R. J. Cleveland, T. A. Schwartz, L. F. Callahan, J. S. Marron, R. F. Loeser; Univ. of North Carolina, Chapel Hill, NC

453 ASSOCIATION BETWEEN METFORMIN USE AND DISEASE PROGRESSION IN OBESE PEOPLE WITH KNEE OSTEOARTHRITIS - DATA FROM THE OSTEOARTHRITIS INITIATIVE

Y. Wang1, S. Hussain1, A. Wluka1, F. Abram2, J-P. Pelletier3, J. Martel-Pelletier3, F. Cicuttini1; 1Monash Univ., Melbourne, Australia, 2Med. Imaging Res. & Dev., ArthroLab Inc., Montreal, QC, Canada, 3Univ. of Montreal Hosp. Res. Ctr., Montreal, QC, Canada

454 ASSOCIATION OF DAILY WALKING WITH THE RISK OF TOTAL KNEE REPLACEMENT OVER 5 YEARS: AN OBSERVATIONAL STUDY H. Master, L. Thoma, M. Christiansen, J. Stefanik, D. Mathews, D. K. White; Univ. of Delaware, Newark, DE

56 | FINAL PROGRAM

455 PAIN MEDICATION REPORTING AND PATIENT-REPORTED OUTCOMES IN THE YEARS PRIOR TO KNEE REPLACEMENT: CHALLENGES TO ASSESSING SYMPTOMATIC EXPERIENCES

C. K. Kwoh1, E. L. Ashbeck1, A. Aydemir2, M. J. Hannon3, H. Guehring4; 1Univ. of Arizona Arthritis Ctr., Tucson, AZ, 2EMD Serono, Billerica, MA, 3Univ. of Pittsburgh and Pittsburgh VAHS, Pittsburgh, PA, 4Merck KGaA, Darmstadt, Germany

456 THE PROPORTION OF PATIENTS ACHIEVING A “GOOD OUTCOME” 1 YEAR AFTER TOTAL KNEE ARTHROPLASTY BASED ON VARYING MEASURES OF TOTAL KNEE ARTHROPLASTY SUCCESS

G. A. Hawker1, E. Waugh1, D. A. Marshall2, A. Jones3, L. Woodhouse3, E. Bohm4, B. Ravi1, J. Squire Howden5, T. Noseworthy2; 1Univ. of Toronto, Toronto, ON, Canada, 2Univ. of Calgary, Calgary, AB, Canada, 3Univ. of Alberta, Edmonton, AB, Canada, 4Univ. of Manitoba, Winnipeg, MB, Canada, 5Alberta Bone & Joint Hlth.Inst., Edmonton, AB, Canada

457 A COMPARISON OF CHARACTERISTICS OF SUBJECTS WITH EARLY KNEE OSTEOARTHRITIS BASED ON TWO DIFFERENT CLASSIFICATION CRITERIA

a. mahmoudian1, I. Baert2, S. M. Verschueren1, F. P. Luyten1; 1KU Leuven, LEUVEN, Belgium, 2Univ. of Antwerp, Antwerp, Belgium

458 LOCAL MRI-BASED MEASURES OF THIGH ADIPOSE AND MUSCLE TISSUE ARE HIGHLY RESPONSIVE TO BIDIRECTIONAL CHANGE IN BODY WEIGHT - DATA FROM THE OSTEOARTHRITISINITIATIVE

E. Steidle-Kloc1, T. Dannhauer1,2, W. Wirth1,2, F. Eckstein1,2; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics GmbH, Ainring, Germany

459 SELF-MANAGEMENT AND FUNCTIONAL STATUS IN ADULTS WITH EARLY TO LATE STAGE KNEE OSTEOARTHRITIS A. CAGNIN1,2, M. CHOINIÈRE2,3, N. J BUREAU2,3, M. DURAND2,3, L. DE POLO1,2, N. HAGEMEISTER1,2; 1École de Technologie Supérieure (ÉTS),

Laboratoire d›Imagerie et d›Orthopédie (LIO), Montréal, QC, Canada, 2Ctr. de Recherche du CHUM (CRCHUM), Montréal, QC, Canada, 3Université de Montréal (UdeM), Montréal, QC, Canada

460 CAN DEPRESSION, FUNCTIONAL PERFORMANCE AND KINESIOPHOBIA PREDICT LOWER PHYSICAL ACTIVITY LEVELS IN PATIENTS WITH KNEE OSTEOARTHRITIS?

G. I. KINIKLI1, H. KILINC1, M. J. CALLAGHAN2, B. ATILLA3, A. M. TOKGOZOGLU3; 1Hacettepe Univ., Faculty of Hlth.Sci., Dept. of Physiotherapy and Rehabilitation, Ankara, Turkey, 2Manchester Metropolitan Univ., Dept. of Hlth.Professions, Manchester, United Kingdom, 3Hacettepe Univ., Faculty of Med., Dept. of Orthopaedics and Traumatology, Ankara, Turkey

461 MAP-HAND - A RELIABLE AND VALID TOOL MEASURING ACTIVITY PERFORMANCE IN PATIENTS WITH HAND OSTEOARTHRITIS A. Tveter1, R. Nossum2, R. Mehl Eide3, Å. Klokkeide4, K. Matre3, M. Olsen4, Ø. Andreassen1, N. Østerås1, I. Kjeken1; 1Diakonhjemmet Hosp., Natl. Advisory Unit

on Rehabilitation in Rheumatology, Oslo, Norway, 2St.Olavs Hosp., Trondheim Univ. Hosp., Trondheim, Norway, 3Haukeland Univ. Hosp., Bergen, Norway, 4Haugesund Rheumatism Hosp. AS, Haugesund, Norway

462 SLEEP INTERVENTIONS FOR OSTEOARTHRITIS AND SPINAL PAIN: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROL TRIALS P. H. Ferreira1, K. K. Ho1, M. B. Pinheiro1, D. Aquino Silva2, C. Miller3, R. Grunstein3, M. Simic1; 1Univ. of Sydney, Sydney, Australia, 2Univ.e Federal de Minas

Gerais, Belo Horizonte, Brazil, 3CIRUS, Sydney, Australia

463 TPX-100 LEADS TO MARKED, SUSTAINED IMPROVEMENTS IN SUBJECTS WITH KNEE OSTEOARTHRITIS: PRE-CLINICAL RATIONALE AND RESULTS OF A CONTROLLED CLINICAL TRIAL

D. McGuire1, N. Lane2, N. Segal3, S. Metyas4, H. Barthel5, M. Miller1, D. Rosen1, Y. Kumagai1; 1OrthoTrophix, Oakland, CA, 2Univ. of California, Davis, Sacramento, CA, 3Kansas Univ. Clinical Res. Ctr., Kansas City, KS, 4Covina Arthritis Ctr., Covina, CA, 5Barthel Clinic, Santa Barbara, CA

464 SELF-REPORTED HOME EXERCISE ADHERENCE - FACT OR FICTION? A VALIDITY AND RELIABILITY STUDY USING CONCEALED ACCELEROMETRY AMONG PEOPLE WITH KNEE OSTEOARTHRITIS.

P. J. Nicolson1, R. S. Hinman1, T. V. Wrigley1, P. W. Stratford2, K. L. Bennell1; 1Univ. of Melbourne, Melbourne, Australia, 2McMaster Univ., Hamilton, ON, Canada

465 PERCEPTION ABOUT RUNNING AND KNEE JOINT HEALTH AMONG THE PUBLIC AND HEALTHCARE PRACTITIONERS J-F. Esculier, N. M. Krowchuk, L. C. Li, J. E. Taunton, M. A. Hunt; Univ. of British Columbia, Vancouver, BC, Canada

466 RADIOGRAPHIC OUTCOMES WERE CONCORDANT WITH OUTCOME MEASURES IN RHEUMATOLOGY-OSTEOARTHRITIS RESEARCH SOCIETY INTERNATIONAL (OMERACT-OARSI) STRICT RESPONSE: POST-HOC ANALYSIS FROM A PHASE 2 STUDY OF A WNT PATHWAY INHIBITOR, SM04690, FOR KNEE OSTEOARTHRITIS TREATMENT

Y. Yazici1, T. E. McAlindon2, A. Gibofsky3, N. E. Lane4, C. J. Swearingen1, J. R. Tambiah1; 1Samumed, San Diego, CA, 2Tufts Med. Ctr., Boston, MA, 3Weill Cornell Med. and Hosp. for Special Surgery, New York, NY, 4UC Davis Med. Ctr., Davis, CA

467 ESTABLISHING BENCHMARKS FOR CHANGE IN BIOMECHANICAL FACTORS LINKED TO KNEE OSTEOARTHRITIS PROGRESSION N. M. Brisson1, P. W. Stratford1, M. R. Maly1,2; 1McMaster Univ., Hamilton, ON, Canada, 2Univ. of Waterloo, Waterloo, ON, Canada

57 | FINAL PROGRAM

468 DO OLDER ADULTS WITH LOW MUSCLE MASS (SARCOPENIA) OR STRENGTH (DYNAPENIA), IN THE PRESENCE OF OBESITY, HAVE AN INCREASED RISK OF JOINT REPLACEMENT OVER 13 YEARS?

D. Aitken1, S. Balogun1, S. E. Graves2, M. Lorimer3, F. Cicuttini4, D. Scott4, G. Jones1; 1Univ. of Tasmania, Hobart, Australia, 2Australian Orthopaedic Association Natl. Joint Replacement Registry (AOANJRR), Adelaide, Australia, 3South Australian Hlth.and Med. Res. Inst. (SAHMRI), Adelaide, Australia, 4Monash Univ., Melbourne, Australia

469 GARDENING ASSOCIATES WITH LESS KNEE PAIN: DATA FROM THE OSTEOARTHRITIS INITIATIVE G. Lo1, J. B. Driban2, A. M. Kriska3, L. Price2, B. J. Rockette-Wagner3, C. B. Eaton4, M. C. Hochberg5, R. D. Jackson6, C. Kwoh7, M. C. Nevitt8, T. E. McAlindon2;

1Baylor Coll. of Med., Houston, TX, 2Tufts Med. Ctr., Boston, MA, 3Univ. of Pittsburgh, Pittsburgh, PA, 4Alpert Med. Sch. of Brown Univ., Pawtucket, RI, 5Univ. of Maryland, Baltimore, MD, 6The Ohio State Univ., Columbus, OH, 7Univ. of Arizona, Tucson, AZ, 8Univ. of California San Francisco, San Francisco, CA

470 MODERATORS OF STRENGTHENING EXERCISE WITH PAIN COPING SKILLS TRAINING FOR PEOPLE WITH KNEE OSTEOARTHRITIS: EXPLORATORY ANALYSIS OF RANDOMISED CONTROLLED TRIAL

M. Hall1, T. Egerton1, F. Keefe2, J. Kasza3, Y. Ahamed4, G. Jull5, M. Hunt6, B. Metcalf1, J. Kenardy5, C. Bryant1, K. Bennell1; 1Univ. of Melbourne, Melbourne, Australia, 2Duke Univ., Durham, NC, 3Monash Univ., Melbourne, Australia, 4Australian Catholic Univ., Melbourne, Australia, 5Univ. of Queensland, Brisbane, Australia, 6Univ. of British Colombia, Vancouver, BC, Canada

471 KNEE CONFIDENCE TRAJECTORIES OVER 8 YEARS AND FACTORS ASSOCIATED WITH POOR TRAJECTORIES: DATA FROM THE OSTEOARTHRITIS INITIATIVE

A. H. Chang, J. Lee, O. Almagor, J. S. Chmiel, K. C. Moisio, K. W. Hayes, J. Szymaszek, L. Sharma; Northwestern Univ., Chicago, IL

472 IS THE USE OF KNEE MAGNETIC RESONANCE IMAGING ONE OF THE DRIVERS OF PERSISTENTLY HIGH ARTHROSCOPY RATES IN OLDER ADULTS? - AN ANALYSIS OF NATIONAL DATA IN AUSTRALIA

L. A. Deveza1, L. Matthews2, R. O’Connell3, D. J. Hunter1; 1Rheumatology Dept., Royal North Shore Hosp. and Inst. of Bone and Joint Res., Kolling Inst., Univ. of Sydney, Sydney, Australia, 2Med. Benefits Div., Dept. of Hlth., Sydney, Australia, 3Natl. Hlth.and Med. Res. Council (NHMRC) Clinical Trial Ctr., Univ. of Sydney, Sydney, Australia

473 METABOLIC SYNDROME AND TRAJECTORIES OF KNEE PAIN F. Pan1, J. Tian1, T. Winzenberg1, F. Cicuttini2, G. Jones1; 1Univ. of Tasmania, Hobart, Australia, 2Monash Univ. Med. Sch., Melbourne, Australia

474 TWO YEAR TIBIOFEMORAL JOINT CARTILAGE LOSS IS WEAKLY CORRELATED WITH INCREASED PAIN AMONG KNEES WITH LOWER BASELINE CARTILAGE THICKNESS

C. K. Kwoh1, E. L. Ashbeck1, A. Aydemir2, M. J. Hannon3, H. Guehring4; 1Univ. of Arizona Arthritis Ctr., Tucson, AZ, 2EMD Serono, Billerica, MA, 3Univ. of Pittsburgh and Pittsburgh VAHS, Pittsburgh, PA, 4Merck KGaA, Darmstadt, Germany

475 EVIDENCE FOR BONE MINERAL DENSITYAND BONE RESORPTION IN MIDDLE AND ELDERLYWOMEN WITH KNEE OSTEOARTHRITIS IN SHANGHAIA: CROSS SECTIONAL STUDY

Q. XIAOFENG; Longhua Hosp., Shanghai Univ. of Traditional Chinese Med., Shanghai , China, SHANGHAI, China

476 ASSESSMENT OF THE SAFETY OF REPEAT ADMINISTRATION OF TRIAMCINOLONE ACETONIDE EXTENDED-RELEASE INJECTABLE SUSPENSION IN PATIENTS WITH KNEE OSTEOARTHRITIS: TRIAL DESIGN, METHODS AND PRELIMINARY DATA

A. Spitzer1, J. Richmond2, A. Gomoll3, D. G. Jones4, V. B. Kraus5, J. Lufkin6, J. R. Johnson7, S. Kelley6; 1Cedars-Sinai Orthopaedic Ctr., Los Angeles, CA, 2New England Baptist Hosp., Dedham, MA, 3Brigham and Women’s Hosp., Chestnut Hill, MA, 4Ochsner Sports Med. Inst., Harahan, LA, 5Duke Univ. Sch. of Med., Durham, NC, 6Flexion Therapeutics, Inc., Burlington, MA, 7Summit Analytical, Denver, CO

477 DIFFERENCES IN PRESENCE OF RADIOGRAPHIC FEATURES BETWEEN TWO REGIONS OF THE HIP IN PATIENTS WITH HIP OSTEOARTHRITIS R. A. Pouw1, M. van der Esch1, M. van der Leeden1, D. J. Reiding2, L. D. Roorda1, J. Dekker3, W. F. Lems4; 1Amsterdam Rehabilitation Res. Ctr., Reade, center

for rehabilitation and rheumatology, Amsterdam, Netherlands, 2Reade Ctr. of Rehabilitation and Rheumatology, Dept. of Radiology, Amsterdam, Netherlands, 3Rehabilitation Med., VU Univ. Med. Ctr., Amsterdam, Netherlands, 4Dept. of Rheumatology, VU Univ. Med. Ctr., Amsterdam, Netherlands

478 QUADRICEPS NEUROMUSCULAR FUNCTION IN PATIENTS WITH AND WITHOUT KNEE OSTEOARTHRITIS FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION

G. E. Norte1, J. N. Hertel2, S. A. Saliba2, D. R. Diduch2, J. M. Hart2; 1Univ. of Toledo, Toledo, OH, 2Univ. of Virginia, Charlottesville, VA

479 THE SHAPE OF ANTERIOR CONDYLE OF THE DISTAL FEMUR AFFECTS RANGE OF MOTION IN THE PATIENTS OF OSTEOARTHRITIS K. Nishitani, S. Kuriyama, S. Nakamura, H. Ito, S. Matsuda; Kyoto Univ., Kyoto, Japan

480 MENTAL HEALTH-RELATED QUALITY OF LIFE AND WORK PERFORMANCE IN ADULTS WITH KNEE OSTEOARTHRTIS A. CAGNIN1,2, M. CHOINIÈRE2,3, N. J BUREAU2,3, M. DURAND2,3, L. DE POLO1,2, N. HAGEMEISTER1,2; 1Ecole de Technologie Supérieure (ÉTS),

Laboratoire d’Imagerie et d’Orthopédie (LIO), Montréal, QC, Canada, 2Ctr. de Recherche du CHUM (CRCHUM), Montréal, QC, Canada, 3Université de Montréal (UdeM), Montréal, QC, Canada

58 | FINAL PROGRAM

481 TRAJECTORIES OF ADHERENCE TO HOME-BASED EXERCISE PROGRAMS AMONG PEOPLE WITH KNEE OSTEOARTHRITIS. P. J. Nicolson1, R. S. Hinman1, J. Kasza2, K. L. Bennell1; 1Univ. of Melbourne, Melbourne, Australia, 2Monash Univ., Melbourne, Australia

482 CAN KNEE OSTEOARTHRITIS PAIN FLARES BE PREDICTED? I. Atukorala1, A. Pathmeswaran2, L. March3, T. Chang1, Y. Zhang4, D. J. Hunter3; 1Univ. of Colombo, Colombo 8, Sri Lanka, 2Univ. of Kelaniya, Ragama, Sri Lanka,

3Inst. of Bone and Joint Res., Kolling Inst., Univ. of Sydney and Rheumatology Dept., Royal North Shore Hosp., Sydney, Australia, 4Clinical Epidemiology Res. and Training Unit, Boston Univ. Sch. of Med., Boston, Mass USA , Boston, MA

483 DOES THE RADIOGRAPHIC SEVERITY OF KNEE OSTEOARTHRITIS CORRELATES WITH THE DURATION OF SYMPTOMS, PAIN INTENSITY AND MEDICATION USE?

L. DE POLO1,2, M. CHOINIÈRE2,3, N. J BUREAU2,3, M. DURAND2,3, A. CAGNIN1,2, N. HAGEMEISTER1,2; 1École de Technologie Supérieure (ÉTS), Laboratoire d›Imagerie et d›Orthopédie (LIO), Montréal, QC, Canada, 2Ctr. de Recherche du CHUM (CRCHUM), Montréal, QC, Canada, 3Université de Montréal (UdeM), Montréal, QC, Canada

484 EFFICACY OF THE JAPANESE FORGOTTEN JOINT SCORE-12 AS AN OUTCOME MEASURE FOR TOTAL KNEE ARTHROPLASTY IN A JAPANESE POPULATION

T. Maeda, M. Kubo, K. Kumagai, K. Uenaka, S. Araki, H. Fujikawa, S. Imai, Y. Matsusue; Shiga Univ. of Med. Sci., Otsu, Shiga, Japan

485 PREDICTING THE DEVELOPMENT OF PERSISTENT KNEE PAIN AND SYMPTOMATIC KNEE OSTEOARTHRITIS AMONG OVERWEIGHT AND OBESE MIDDLE-AGED WOMEN IN GENERAL PRACTICE

M. L. Landsmeer1, J. Runhaar1, M. van Middelkoop1, E. H. Oei2, P. J. Bindels1, S. M. Bierma-Zeinstra1,3; 1Dept. of Gen. Practice, Erasmus MC, Univ. Med. Ctr., Rotterdam, Netherlands, 2Dept. of Radiology & Nuclear Med., Erasmus MC, Univ. Med. Ctr., Rotterdam, Netherlands, 3Dept. of Orthopaedics, Erasmus MC, Univ. Med. Ctr., Rotterdam, Netherlands

486 EVALUATING THE PROPENSITY OF AN ELEVATED NUTRITIONAL RISK IN OSTEOARTHRITIS: DATA FROM THE CANADIAN LONGITUDINAL STUDY ON AGING

D. A. Duarte-Dyck1, E. G. Wiebenga2, J. N. Chopp-Hurley2, H. H. Keller3, J. G. Tamez-Peña1, M. R. Maly3,2; 1Monterrey Inst. of Technology and Higher Ed., Monterrey, Mexico, 2McMaster Univ., Hamilton, ON, Canada, 3Univ. of Waterloo, Waterloo, ON, Canada

487 COMORBID HEALTH CONDITIONS AND THEIR ASSOCIATIONS WITH OUTCOMES AMONG AFRICAN AMERICANS WITH KNEE OSTEOARTHRITIS K. D. Allen1,2, L. Arbeeva1, C. Coffman3,2, C. Cené1, L. Campbell4, F. Keefe3, E. Oddone3,2, T. Somers3, Y. Watkins5; 1Univ. of North Carolina, Chapel Hill, NC,

2Dept. of VA Med. Ctr., Durham, NC, 3Duke Univ. Med. Ctr., Durham, NC, 4East Carolina Univ., Greenville, NC, 5Chicago State Univ., Chicago, IL

488 IS PLAYING POSITION, PLAYING STANDARD OR LENGTH OF PLAY ASSOCIATED WITH JOINT SPECIFIC OSTEOARTHRITIS IN CRICKETERS? S. R. Filbay1, M. T. Sanchez-Santos1, N. Peirce2, N. K. Arden1; 1Univ. of Oxford, Oxford, United Kingdom, 2Loughborough Univ., Leicester, United Kingdom

489 THE HAND OSTEOARTHRITIS OF NEW YORK UNIVERSITY (HONEY) COHORT: SPECTRUM OF DISEASE IN A RHEUMATOLOGY FACULTY PRACTICE F. Bomfim, S. Chen, S. Zak, T. Jazrawi, R. Cohen, M. Kundler, A. Chebli, J. Samuels; NYU Langone Hlth., New York, NY

490 MUSCLE CO-CONTRACTION DURING GAIT FOLLOWING TOTAL KNEE ARTHROPLASTY IS CHALLENGED BY HIGHER VELOCITY, NOT BY A COGNITIVE DUAL TASK

M. Booij, Jr.1, K. Apeldoorn, Jr.1, B. Royen1, J. Noort2, J. Harlaar1,3; 1VU Med. center, Amsterdam, Netherlands, 2AMC, Amsterdam, Netherlands, 3TU Delft, Delft, Netherlands

491 DISEASE BURDEN IN RHEUMATOLOGY ROUTINE CARE SETTING IS SIMILAR IN OSTEOARTHRITIS (OA) AND RHEUMATOID ARTHRITIS (RA) AT FIRST VISIT BUT SIGNIFICANTLY GREATER IN OA AT A 6-MONTH FOLLOW-UP VISIT

J. R. Chua, T. Pincus, I. Castrejon; Rush Univ., Chicago, IL

492 QUANTITATIVE AND TOPOGRAPHIC ASSESSMENT OF HEBERDEN’S NODES FOR PREDICTION OF KNEE OSTEOARTHRITIS: DATA FROM OSTEOARTHRITIS INITIATIVE

N. Kumar1, N. Hafezi-Nejad2, A. Guermazi3, A. Haj-Mirzaian1, I. Haugen4, F. Roemer3, S. Demehri1; 1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, 2Univ. System of Maryland, Baltimore, MD, 3Boston Univ. Sch. of Med., Boston, MA, 4Diakonhjemmet Hosp., Oslo, Norway

493 PATIENTS GENOTYPE AND OA TREATMENT EFFICACY L. Khimion1, A. Buryanov2, L. Smolina1, T. Omelchenko2; 1Shupyk Natl. Med. Academy of Postgraduate Ed., Kyiv, Ukraine, 2Bogomolets Natl. Med. Univ., Kyiv, Ukraine

494 A VALIDATION STUDY OF THE ARABIC VERSION OF THE OXFORD KNEE SCORE FOR USE IN END STAGE KNEE OSTEOARTHRITIS B. Bin sheeha1, A. Williams1, D. Johnson2, A. Bin Nasser3, M. Granat1, R. Jones4; 1Univ. of Salford, Manchester, United Kingdom, 2Stockport NHS Fndn. Trust,

manchester, United Kingdom, 3King Khalid Univ. Hosp., Riyadh, Saudi Arabia, 4Univ. of Salford, manchester, United Kingdom

59 | FINAL PROGRAM

495 THE INFLUENCE OF METABOLIC DISORDERS ON X-RAY CHANGES IN PATIENTS WITH OSTEOARTHRITIS AND THE METHOD FOR THEIR PREDICTION

M. Oliinyk, L. Zhuravlyova; Kharkiv Natl. Med. Univ., Kharkiv, Ukraine

496 ADHERENCE TO MIND-BODY THERAPIES FOR KNEE OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS M. Shaw, M. Park, R. R. Bannuru, C. Wang; Tufts Med. Ctr./Tufts Univ. Sch. of Med., Boston, MA

497 MULTI-DISCIPLINARY CARE FOR KNEE AND HIP OSTEOARTHRITIS: HYPOTHESIS GENERATING DATA FROM A NOVEL UNIVERSITY BASED CLINIC K. A. Miller, D. Feldstein, L. Baier Manwell, D. Rabago; Univ. of Wisconsin, Madison, WI

498 WE MIGHT BE GETTING IT WRONG IF WE DO NOT CONSIDER GENETICS IN OSTEOARTHRITIS AND BACK PAIN: INSIGHTS FROM TWIN STUDIES P. Ferreira, M. Ferreira, M. Pinheiro, J. Zadro, A. Dario, A. Amorim, M. Fernandez, K. Ho; Univ. of Sydney, Sydney, Australia

499 PECULIARITIES OF TREATMENT OF PATIENTS WITH OSTEOARTHRITIS ON THE BACKGROUND OF DISLIPIDEMIA V. Protsenko1, G. Protsenko2; 1Inst. of Traumatology and Orthopedics of the Natl. Academy of Med. Sci. of Ukraine, Kiev, Ukraine, 2Natl. Scientific Ctr. “M.D.

Strazhesko Inst. of Cardiology” MAS of Ukraine, Kiev, Ukraine

500 EFFECT OF ACUPOTOMY THERAPY ON JOINT PAIN IN KOA AND ANALYSIS OF CARTILAGE SURFACE STRESS BASED ON BOWSTONES THEORY B. Dong1, G. OU2, J. Yao2, P. Yuan1, D. Liu1, X. Li1; 1Affiliated Hosp. of Shaanxi Univ. of Chinese Med., XianYang, China, 2Shaanxi Univ. of Chinese Med., XianYang, China

501 PATIENT-REPORTED OUTCOMES OF FILIPINOS WITH KNEE OSTEOARTHRITIS ENROLLED IN THE OSTEOARTHRITIS MULTIDISCIPLINARY CLINIC: A CROSS-SECTIONAL STUDY AT THE UNIVERSITY OF THE PHILIPPINES - PHILIPPINE GENERAL HOSPITAL

P. Francisco, L. Nicodemus, S. Laviña, E. G. Penserga; Univ. of the Philippines - Philippine Gen. Hosp., Manila, Philippines

502 PAIN-RELATED DIRECT MEDICAL EXPENDITURES AMONG ELDERLY CHINESE X. Li, Q. Liu, Z. Zhou, Z. Li, J. Lin; Peking Univ. People’s Hosp., Beijing, China

HEALTH SERVICES RESEARCH503 IMPLEMENTING INTERNATIONAL OSTEOARTHRITIS GUIDELINES IN PRIMARY HEALTH CARE - EVALUATING FIDELITY AND UPTAKE IN A

CLUSTER RANDOMIZED CONTROLLED STUDY T. Moseng, H. Dagfinrud, N. Østerås; Diakonhjemmet Hosp., Oslo, Norway

504 IMPLEMENTING AN ICHOM STANDARD SET TO CAPTURE OSTEOARTHRITIS OUTCOMES IN REAL WORLD CLINICAL SETTINGS B. Cavka1, I. N. Ackerman2,3, A. Bucknill1,3; 1Melbourne Hlth., Melbourne, Australia, 2Monash Univ., Melbourne, Australia, 3The Univ. of Melbourne, Melbourne, Australia

505 GENERAL PRACTITIONERS’ VIEWS ON MANAGING KNEE OSTEOARTHRITIS: FACTORS INFLUENCING CLINICAL PRACTICE GUIDELINE IMPLEMENTATION IN PRIMARY CARE

T. Egerton1, R. K. Nelligan1, J. Setchell2, L. Atkins3, K. L. Bennell1; 1The Univ. of Melbourne, Melbourne, Australia, 2The Univ. of Queensland, Brisbane, Australia, 3Univ. Coll. London, London, United Kingdom

506 WORSENING ADHERENCE TO OARSI GUIDELINES FOR THE NON-OPERATIVE MANAGEMENT OF HIP AND KNEE OSTEOARTHRITIS D. F. Hamilton1, C. Beadle1, F. C. Loth2, C. Howie1, G. Nuki1; 1Univ. of Edinburgh, Edinburgh, United Kingdom, 2Univ. of Innsbruck, Innsburck, Austria

507 IMPROVING ACCESS TO CARE AND TREATMENT FOR PATIENTS WITH HIP AND KNEE PAIN AT THE INTERFACE BETWEEN PRIMARY AND SECONDARY CARE

K. Button1, D. Owen1, T. M. Lau1, I. Spasic1, R. Playle1, L. Hannaway2, S. Jones3; 1Cardiff Univ., Cardiff, United Kingdom, 2Brynderwen & Minster Surgeries, Cardiff, United Kingdom, 3Cardiff & Vale UHB, Cardiff, United Kingdom

508 DEVELOPMENT OF A SERVICE DELIVERY INTERVENTION AND IMPLEMENTATION PLAN FOR OPTIMISING PRIMARY CARE MANAGEMENT OF KNEE OSTEOARTHRITIS: THE PARTNER PROJECT

T. Egerton1, K. L. Bennell1, R. Hinman1, D. J. Hunter2, J. Bowden2, P. J. Nicolson1, L. Atkins3, M. Pirotta1, and the PARTNER Project team; 1The Univ. of Melbourne, Melbourne, Australia, 2The Univ. of Sydney, Sydney, Australia, 3Univ. Coll. London, London, United Kingdom

509 EVALUATION OF THE SELF MANAGEMENT OF OSTEOARTHRITIS AND LOW BACK PAIN THROUGH ACTIVITY AND SKILLS PHYSIOTHERAPIST E-LEARNING TRAINING PROGRAMME COMPARED TO FACE TO FACE TRAINING

D. A. Hurley1, A. Keogh1, A. Hall2, H. Richmond3, T. Magdalinski4, J. Matthews1; 1Univ. Coll. Dublin, Dublin, Ireland, 2Mem. Univ., St Johns, NL, Canada, 3Univ. of Oxford, Oxford, United Kingdom, 4Swinburne Univ. of Technology, Melbourne, Australia

510 RACE AND GENDER DISPARITIES IN PHYSICAL FUNCTION BEFORE AND AFTER TOTAL HIP ARTHROPLASTY: A RETROSPECTIVE ANALYSIS A. M. Bove, J. Porter, A. Sayeed, B. Klatt; Univ. of Pittsburgh, Pittsburgh, PA

60 | FINAL PROGRAM

511 OPTIMISING PRIMARY CARE MANAGEMENT OF KNEE OSTEOARTHRITIS (PARTNER): PROTOCOL FOR A RANDOMISED CONTROLLED TRIAL D. J. Hunter1, R. S. Hinman2, J. L. Bowden1, T. Egerton2, A. M. Briggs3, S. J. Bunker4, A. B. Forbes5, S. D. French6, J. Kasza5, M. Pirotta2, D. J. Schofield1, N. A.

Zwar7, K. L. Bennell2, PARTNER Study Group; 1Univ. of Sydney, Sydney, Australia, 2Univ. of Melbourne, Melbourne, Australia, 3Curtin Univ., Perth, Australia, 4Medibank, Melbourne, Australia, 5Monash Univ., Melbourne, Australia, 6Queen’s Univ., Kingston, ON, Canada, 7Univ. of Wollongong, Wollongong, Australia

512 OSTEOARTHRITIS CLINICAL TRIAL DESIGN AND FOOD AND DRUG ADMINISTRATION ACCELERATED APPROVAL: LESSONS LEARNED FROM THE OSTEOPOROSIS AND LIVER FIBROSIS FIELDS

M. A. Karsdal1, A-C. Bay-Jensen1, A. R. Bihlet1, V. B. Kraus2, I. Byrjalsen1, J. R. Andersen1; 1Nordic BioSci., Herlev, Denmark, 2Duke Molecular Physiology Inst., Durham, NC

CLINICAL RESEARCH METHODS513 EXPLORING THE USE OF ONLINE SOCIAL MEDIA ADVERTISING TO RECRUIT PATIENTS IN AN OSTEOARTHRITIS CLINICAL TRIAL C. Ferrigno, J. He, C. P. Cordova, J. Fair, N. Shakoor, M. A. Wimmer; Rush Univ., Chicago, IL

514 MINIMAL IMPORTANT CHANGE DETERMINED WITH A NOVEL METHOD FOCUSING ON PATIENTS’ PERSPECTIVES OF IMPORTANT CHANGE FOR THE OXFORD KNEE SCORE AND THE FORGOTTEN JOINT SCORE AFTER KNEE REPLACEMENT

L. H. Ingelsrud1,2, E. M. Roos1, K. Gromov2, H. Husted2, B. Terluin3, A. Troelsen2; 1Univ. of Southern Denmark, Odense M, Denmark, 2Copenhagen Univ. Hosp. Hvidovre, Copenhagen, Denmark, 3VU Univ. Med. Ctr., Amsterdam, Netherlands

515 THE APPROACH CONSORTIUM: A 2-YEAR, EUROPEAN, COHORT STUDY TO DESCRIBE, VALIDATE, AND PREDICT PHENOTYPES OF KNEE OSTEOARTHRITIS BY USE OF CLINICAL, IMAGING, AND BIOCHEMICAL MARKERS

E. M. van Helvoort1, W. E. van Spil1, A. C. Marijnissen1, P. M. Welsing1, A. C. Bay-Jensen2, L. Hussaarts3, C. Ladel4, A. Lalande5, J. Larkin6, M. C. Levesque7, J. Loughlin8, A. Mobasheri9, L. Paolozzi5, F. Petit-Dop5, H. Weinans1, F. P. Lafeber1; 1Dept. of Rheumatology & Clinical Immunology, Univ. Med. Ctr. Utrecht, Univ. Utrecht, Utrecht, Netherlands, 2Nordic BioSci., Biomarkers and Res., Herlev, Denmark, 3Lygature, Utrecht, Netherlands, 4Merck KGaA, Darmstadt, Germany, 5Inst. de Recherches Intl.es Servier, Suresnes, France, 6GlaxoSmithKline, King of Prussia, PA, 7Abbvie, Inc., Worcester, MA, 8Inst. of Genetic Med., Newcastle Univ., Newcastle, United Kingdom, 9Faculty of Hlth.and Med. Sci., Univ. of Surrey, Surrey, United Kingdom

516 CURRENT PRACTICE IN METHODOLOGY AND REPORTING OF THE SAMPLE SIZE CALCULATION IN RANDOMISED TRIALS OF HIP AND KNEE OSTEOARTHRITIS: A SYSTEMATIC REVIEW

B. Copsey, J. Y. Thompson, K. Vadher, U. Ali, S. J. Dutton, R. Fitzpatrick, S. E. Lamb, J. A. Cook; Univ. of Oxford, Oxford, United Kingdom

517 RECRUITMENT, RANDOMIZATION AND RETENTION: UK EXPERIENCE OF THE ‘3 RS’ IN OSTEOARTHRITIS DRUG TRIALS TARGETING PAIN S. Masters1, P. Lovegrove1, C. Pereira1, M. Goff1, G. Lang1, T. L. Vincent1, K. Barker2, N. K. Arden1, A. Taylor2, N. Bottomley2, W. Jackson2, A. Price1, F. E. Watt1;

1Univ. of Oxford, Oxford, United Kingdom, 2Oxford Univ. Hosp. NHS Fndn. Trust, Oxford, United Kingdom

518 JOINT SPACE WIDTH INCLUSION CRITERIA CAN REDUCE KNEE OSTEOARTHRITIS TRIAL HETEROGENEITY: POST-HOC DATA FROM A PHASE 2 TRIAL OF WNT PATHWAY INHIBITOR, SM04690

P. Conaghan1, J. Tambiah2, C. J. Swearingen2, S. Kennedy2, M. Bowes3, A. Brett3, C. Lattermann4; 1Univ. of Leeds, Leeds, United Kingdom, 2Samumed, San Diego, CA, 3Imorphics, Manchester, United Kingdom, 4Univ. of Kentucky, Lexington, KY

519 DATA HARMONISATION ACROSS DATABASES FOR MACHINE LEARNING MODEL DEVELOPMENT TO PREDICT KNEE OSTEOARTHRITIS PROGRESSION

S. Danso1, P. Widera1, P. M. Welsing2, S. Peelen3, A. Tielmann4, F. Berenbaum5, F. J. Blanco6, I. K. Haugen7, L. Hussaarts3, M. Kloppenburg8, F. Lafeber2, J. Larkin9, M. C. Levesque10, A. Mobasheri11, L. Paolozzi12, F. Petit-Dop12, J. Sellam5, W. E. van Spil2, H. Weinans2, C. Ladel4, J. Loughlin1, J. Bacardit1, for the APPROACH consortium;1Newcastle Univ., Newcastle upon Tyne, United Kingdom, 2Univ.ir Medisch Centrum Utrecht, Utrecht, Netherlands, 3Lygature, Utrecht, Netherlands, 4Merck, Darmstadt, Germany, 5Hosp. Saint-Antoine, Paris, France, 6Servizo Galego de Saude, A Coruña, Spain, 7Diakonhjemmet Hosp. AS, Oslo, Norway, 8Leids Univ.ir Medisch Centrum, Leiden, Netherlands, 9GlaxoSmithKline, Philadelphia, PA, 10AbbVie, Chicago, IL, 11Univ. of Surrey, Guildford, United Kingdom, 12Inst. de Recherches Servier, Suresnes, France

520 THE PATIENT ENABLEMENT INSTRUMENT - A VALIDATION STUDY K. Åkesson, E. Ekvall Hansson, Sr., A. Sundén, K. Stigmar; . Dept. of Hlth.Sci., Lund Univ., Lund, Sweden

521 RECRUITMENT PROCEDURE TO MAXIMISE INCLUSION OF PROGRESSORS IN OA CLINICAL STUDIES USING SUBJECTS FROM EXISTING COHORTS P. Widera1, P. M. Welsing2, S. Danso1, S. Peelen3, F. Lafeber2, F. Petit-Dop4, H. Weinans2, J. Larkin5, L. Hussaarts3, L. Paolozzi4, I. K. Haugen6, F. J. Blanco7, M.

Kloppenburg8, F. Berenbaum9, J. Sellam9, W. E. van Spil2, A. Mobasheri10, M. C. Levesque11, A-C. Bay-Jensen12, A. Tielmann13, C. Ladel13, J. Loughlin1, J. Bacardit1, for the APPROACH consortium; 1Newcastle Univ., Newcastle upon Tyne, United Kingdom, 2Univ. Med. Ctr. Utrecht, Utrecht, Netherlands, 3Lygature, Utrecht, Netherlands, 4Servier, Suresnes, France, 5GlaxoSmithKline, King of Prussia, PA, 6Diakonhjemmet Hosp., Oslo, Norway, 7SERGAS, A Coruña, Spain, 8Leiden Univ. Med. Ctr., Leiden, Netherlands, 9Saint Antoine Hosp., Paris, France, 10Univ. of Surrey, Guildford, United Kingdom, 11AbbVie, Chicago, IL, 12Nordic BioSci., Herlev, Denmark, 13Merck, Darmstadt, Germany

61 | FINAL PROGRAM

522 STUDY DESIGN OF A PHASE I, PLACEBO-CONTROLLED, FIRST-IN-HUMAN TRIAL TO ASSESS SAFETY AND TOLERABILITY, IMMUNOGENICITY, AND PHARMACOKINETICS AND PHARMACODYNAMICS OF SINGLE ASCENDING DOSES OF THE ANTI-ADAMTS-5 NANOBODY®, M6495, IN HEALTHY MALE SUBJECTS

T. Balchen1, R. Strotmann2, A. Reinstrup Bihlet3, J. Sonne4, C. Ladel2, F. Moreau2, H. Guehring2; 1DanTrials ApS c/o Bispebjerg and Frederiksberg Hosp., Copenhagen, Denmark, 2Merck KGaA, Darmstadt, Germany, 3Nordic BioSci., Clinical Dev., Herlev, Denmark, 4Dept. of Clinical Pharmacology, Bispebjerg and Frederiksberg Hosp., Copenhagen, Denmark

523 EFFECTIVENESS OF INTRAMUSCULAR CORTICOSTEROID INJECTION VERSUS INTRA-ARTICULAR INJECTION IN PATIENTS WITH KNEE OSTEOARTHRITIS: DESIGN OF AN OPEN PRAGMATIC RANDOMIZED CONTROLLED TRIAL

M. F. Mol1, S. M. Bierma-Zeinstra1, D. M. Dorleijn1, P. K. Bos1, M. Vis1, J. Gussekloo2, P. J. Bindels1, P. A. Luijsterburg1; 1Erasmus Med. Ctr., Rotterdam, Netherlands, 2Univ. Med. Ctr., Leiden, Netherlands

524 VENOUS THROMBOEMBOLISM AFTER TOTAL JOINT ARTHROPLASTY FROM A JAPANESE MULTICENTER STUDY WITH SUBACUTE AND LONG TERM FOLLOW-UP

K. Kumagai1, S. Motokawa1,2, Y. Makino3,1, K. Aoyagi4, K. Migita1,5; 1Nagasaki Med. Ctr., Ohmura, Japan, 2Nagasaki Rehabilitation Coll., Ohmura, Japan, 3Makino Orthopedic Clinic, Sasebo, Japan, 4Nagasaki Univ. Graduate Sch. of BioMed. Sci., Nagasaki, Japan, 5Fukushima Med. Univ., Fukushima, Japan

THERAPY – SURGERY525 ACHIEVING IMPORTANT IMPROVEMENT IN WOMAC PAIN AND FUNCTION BY THREE MONTHS POST-SURGERY INFLUENCES

SATISFACTION 1 YEAR FOLLOWING TOTAL KNEE REPLACEMENT A. Davis1, S. Ibrahim2, S. Hogg-Johnson3, R. Wong1, D. Beaton2, B. Chesworth4, R. Gandhi5, N. Mahomed5, A. Perruccio1, V. Rajgopal6, J. Waddell7; 1Krembil Res.

Inst., Toronto, ON, Canada, 2Inst. for Work and Hlth., Toronto, ON, Canada, 3Canadian Mem. Chiropractic Coll., Toronto, ON, Canada, 4Western Univ., London, ON, Canada, 5Toronto Western Hosp., Toronto, ON, Canada, 6Strathroy Middlesex Hosp., Strathroy, ON, Canada, 7St. Michael’s Hosp., Toronto, ON, Canada

526 DECREASED MEDIAL COMPARTMENT LOADING AND INCREASED MEDIAL FEMOROTIBIAL ARTICULAR CARTILAGE THICKNESS 12 MONTHS AFTER LIMB REALIGNMENT SURGERY

R. Moyer1, T. Birmingham2, A. Lorbergs2, F. Eckstein3, W. Wirth3, J. R. Giffin2; 1Dalhousie Univ., Halifax, NS, Canada, 2The Univ. of Western Ontario, London, ON, Canada, 3Paracelsus Med. Univ. Salzburg & Nuremberg, Salzburg, Austria

527 PAIN REDUCTION AFTER HIGH TIBIAL OSTEOTOMY WAS ASSOCIATED WITH REDUCTION OF HISTOLOGICAL SYNOVITIS IN PATIENTS WITH KNEE OSTEOARTHRITIS -A LONGITUDINAL STUDY

H. Kaneko1, L. Liu1,2, H. Arita1, T. Aoki2, Y. Negishi1, M. Momoeda1, S. Hada1, Y. Okada3, K. Kaneko1,2, M. Ishijima1,2; 1Dept. of Med. for Orthopaedics and Motor Organ, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 2Sportology Ctr., Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 3Dept. of Pathophysiology for Locomotive and Neoplastic Diseases, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan

528 COST-EFFECTIVENESS OF A LOCKING VERSUS NON-LOCKING RECONSTRUCTION PLATE IN MEDIAL OPENING WEDGE HIGH TIBIAL OSTEOTOMY: THE IMPORTANCE OF COSTING PERSPECTIVE

C. Primeau1,2, J. Marsh1, T. Birmingham1,2, J. Giffin1,2; 1Bone and Joint Inst., Western Univ., London, ON, Canada, 2Wolf Orthopaedic Biomechanics Lab., Fowler Kennedy Sport Med. Clinic, London, ON, Canada

529 AN EVALUATION OF SURVIVAL MODELLING APPROACHES FOR PERSONALISED RISK PREDICTION AFTER HIP REPLACEMENT FOR OSTEOARTHRITIS

P. Aram1, L. Trela-Larsen2, A. Sayers2, A. F. Hills1, A. W. Blom2, E. V. McCloskey1, V. Kadirkamanathan1, J. M. Wilkinson1; 1Univ. of Sheffield, Sheffield, United Kingdom, 2Univ. of Bristol, Bristol, United Kingdom

530 PREVALENCE AND SEVERITY OF SYMPTOMS AND LIMITATIONS AND CHANGES IN THESE ONE YEAR AFTER MENISCAL SURGERY: A COHORT STUDY OF 641 PATIENTS BETWEEN 18 AND 76 YEARS WITH A MENISCAL TEAR

S. T. Skou1,2, K. Pihl1, N. Nissen3, U. Jørgensen4, J. B. Thorlund1; 1Univ. of Southern Denmark, Odense, Denmark, 2Næstved-Slagelse-Ringsted Hosp., Slagelse, Denmark, 3Dept. of Orthopaedic Surgery, Lillebælt Hosp. in Kolding, Kolding, Denmark, 4Dept. of Orthopaedics and Traumatology, Odense Univ. Hosp., Odense, Denmark

531 PROPHALAXIS OF INCIDENCE OF DEEP VEIN THROMBOSIS (VTE) IN LOWER LIMBS AFTER TOTAL KNEE ARTHROPLASTY (TKA) IN PATIENTS WITH KNEE OSTEOARTHRITIS BY EICOSAPENTAENOIC ACID (EPA) ADMINISTRATION -A CASE-CONTROL STUDY

J. SHIOZAWA1, M. Ishijima1, H. Kaneko1, M. Nagayama1, M. Shimizu2, T. Miyazaki2, K. Shimada2, L. Liu1, Y. Takazawa1, H. Ikeda1, H. Daida2, K. Kaneko1; 1Dept. of Med. for Orthopaedics and Motor Organ, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 2Dept. of Med. for Cardiology, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan

532 LONG-TERM BENEFIT AND SURVIVAL OF KNEE JOINT DISTRACTION AS TREATMENT OF SEVERE KNEE OSTEOARTHRITIS M. P. Jansen, G. S. Van der Weiden, R. J. Custers, S. C. Mastbergen, F. P. Lafeber; Univ. Med. Ctr. Utrecht, Utrecht, Netherlands

62 | FINAL PROGRAM

533 THE EFFECT OF CORONAL ALIGNMENT ON THE DOCOTR-DERIVED OUTCOME, PATIENT-REPORTED OUTCOME, AND THE PATIENT STISFACTION AFTER TOTAL KNEE ARTHROPLASTY

M. Kubo, T. Maeda, K. Kumagai, S. Imai; Shiga Univ. of Med. Sci., otsu, Japan

534 PRIMARY TOTAL KNEE ARTHROPLASTY FOR OSTEOARTHRITIS: THE INFLUENCE OF SOFT TISSUE BALANCING ON POSTOPERATIVE CONTACT KINEMATICS

J. S. Webster1, J. L. Howard2,3, D. Bryant1, M. G. Teeter1,4, B. A. Lanting1,3; 1Bone and Joint Inst., Western Univ., London, ON, Canada, 2Western Univ., London, ON, Canada, 3Dept. of Surgery, London Hlth.Sci. Ctr., London, ON, Canada, 4Robarts Res. Inst., London, ON, Canada

535 DISTRIBUTION, QUANTIFICATION AND EFFECTS OF TRIAMCINOLONE ACETONIDE IN HUMAN OSTEOARTHRITIC CARTILAGE F. P. BARRÉ1, M. PAINE1, B. FLINDERS1, M. EVEQUE-MOURROUX1, J. GARCIA2, S. ELLIS1, R. M. HEEREN1, L. CREEMERS2, B. CILLERO PASTOR1;

1M4I, Maastricht, Netherlands, 2UMC Utrecht, Orthopedics Dept., Utrecht, Netherlands

THERAPY – INTRAARTICULAR536 DISEASE MODIFYING EFFECTS OF THE CANINE IL4-10 FUSION PROTEIN IN THE CANINE GROOVE MODEL OF OSTEOARTHRITIS E. M. van Helvoort1, J. Popov-Celeketic1, K. Coeleveld1, A. Doornenbal2, M. A. Tryfonidou2, C. D. Wijne1, F. P. Lafeber1, S. C. Mastbergen1; 1Dept. of

Rheumatology & Clinical Immunology, Univ. Med. Ctr. Utrecht, Univ. Utrecht, Utrecht, Netherlands, 2Dept. of Clinical Sci. of Companion Animals, Faculty of Vet. Med., Utrecht Univ., Utrecht, Netherlands

537 PREPARATION OF A NOVEL INTRA-ARTICULAR POLYMERIC DRUG DELIVERY SYSTEM I. J. Villamagna1, F. Beier1, E. R. Gillies1, M. Hurtig2; 1Univ. of Western Ontario, London, ON, Canada, 2Ontario Vet. Coll., Guelph, ON, Canada

538 MATRIX METALLOPROTEASE 3 (MMP3) INHIBITION EFFECT OF A VISCOSUPPLEMENT BASED ON A HYALURONIC ACID AMIDE DERIVATIVE (HYADD4)

C. Guarise1, M. Pavan1, D. Galesso1, N. Giordan1, S. Moro2, V. Salmaso2, R. Gerli3, P. Gresele3; 1Fidia Pharma Group, Abano Terme (PD), Italy, 2Dept. of Pharmaceutical and Pharmacological Sci., University of Padova, Italy, 3Internal Med. Dept., University of Perugia, Italy

539 SODIUM SUCCINATE AND HYALURONIC ACID IN KNEE OSTEOARTHRITIS TREATMENT O. Burianov1, L. Khimion2, T. Omelchenko1, H. Havryliuk2; 1Bogomolets Natl. Med. Univ., Kyiv, Ukraine, 2Shupyk Natl. Med. Academy of Postgraduate Ed., Kyiv, Ukraine

540 INTRA-ARTICULAR ADMINISTRATION OF HYDROGEN SULPHIDE AMELIORATES SEVERITY OF EXPERIMENTAL OSTEOARTHRITIS Á. Vela-Anero1, T. Hermida-Gomez2,3, P. Filgueira-Fernández2,4, L. Gato-Calvo2,3, E. F. Burguera2,3, R. Meijide-Failde1, F. J. Blanco2,3; 1Grupo de Terapia Celular

y Med. Regenerativa, Dep. de Ciencias Biomedicas, Med. y Fisioterapia. Univ. de A Coruña (UDC). Inst. de Investigación Biomédica de A Coruña, A Coruña, Spain, 2Unidad de Med. Regenerativa, Grupo de Investigación en Reumatología (GIR), Inst. de Investigación Biomédica de A Coruña, A Coruña, Spain, 3Centro de Investigaciones Científicas Avanzadas (CICA), Univ. de A Coruña (UDC), A Coruña, Spain, 4CIBER-BBN, Madrid, Spain

541 DEFINING THE PREDICTIVE UTILITY OF THE MOUSE DMM MODEL OF OSTEOARTHRITIS FOR TESTING/DEVELOPING THERAPEUTIC AGENTS S. Zaki1,2, C. Little2; 1SSVS Faculty of Sci., Univ. of Sydney, Sydney, Australia, 2IBJR Kolling Inst., Univ. of Sydney, St Leonards, Australia

542 CELECOXIB MODULATES RELEASE OF DIFFERENT PROSTANOID SUBTYPES BY INTRA-ARTICULAR TISSUES: TOWARDS CELECOXIB BASED INTRA-ARTICULAR TREATMENT FOR OA MODULATION?

U. Timur1, M. Caron1, R. Jeuken1, Y. Bastiaansen-Jenniskens2, L. van Rhijn1, T. Welting1, G. van Osch2, P. Emans1; 1Maastricht Univ., Maastricht, Netherlands, 2Erasmus MC, Rotterdam, Netherlands

543 HYALURONAN DERIVATIVE HYMOVIS® INCREASES CARTILAGE VOLUME AND TYPE II COLLAGEN TURNOVER IN OSTEOARHRITIC KNEE: DATA FROM MOKHA STUDY.

Y. Henrotin1, R. Bannuru2, M. Malaise3, H-K. EA4, C. Confavreux5, J. Bentin6, D. Urbin-Choffray7, T. Conrozier8, J-P. Brasseur9, P. Thomas10, A. Marinello11, N. Giordan11, P. Richette4; 1Univ. of Liège, Liège, Belgium, 2Tufts Med. Ctr., Boston, MA, 3CHU Sart-Tilman, Liège, Belgium, 4Ctr. Viggo Petersen, Hôpital Lariboisière,, Paris, France, 5Hospices Civils de Lyon, Lyon, France, 6CHU Brugmann, Bruxelles, Belgium, 7CHR Citadelle, Liege, Belgium, 8Hôpital Nord Franche-Comté, Trévenans, France, 9CHU UCL Namur - Site de Godinne, Yvoir, Belgium, 10CHR Metz-Thionville - Hôpital Bel Air, Thionville, France, 11Fidia Farmaceutici, S.p.A, Albano, Terne, Italy

544 STABILITY OF THE VISCOELASTIC PROPERTIES OF HYALURONIC ACID HYDROGELS WITH DIFFERENT CROSSLINKING DEGREES IN IN-VITRO MODELS OF OXIDATIVE STRESS

J. G. Prieto1, B. Lázaro1, A. Rodríguez1, D. García1, A. García1, I. Álvarez1, G. Merino1, F. Marzo2, P. Alonso1; 1Univ. of León, León, Spain, 2Publ. Univ. of Navarra, Pamplona, Spain

545 MANGANESE DIOXIDE NANOPARTICLES MITIGATE OXIDATIVE STRESS IN OSTEOARTHRITIC CARTILAGE S. Kumar, I. M. Adjei, B. Sharma; Univ. of Florida, Gainesville, FL

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546 THE SUITABLE USE OF INTRA-ARTICULAR CORTICOSTEROID INJECTION IN KNEE OSTEOARTHRITIS S. Takagi1, J. D. Blaha2; 1Sado general Hosp., Sado, Japan, 2Univ. of Michigan, Ann Arbor, MI

547 SAFETY ASSESSMENT OF INTRA-ARTICULAR 2.5 % POLYACRYLAMIDE HYDROGEL FOR TREATMENT OF KNEE OSTEOARTHRITIS A. Overgaard, Sr., M. Henriksen, Sr., H. Bliddal; Frederiksberg-Bispebjerg Hosp., Copenhagen, Denmark

548 IL4-10 FUSION PROTEIN AS A DISEASE MODIFYING THERAPY FOR OSTEOARTHRITIS EVALUATED IN A RAT GROOVE MODEL IN VIVO J. Popov-Celeketic1, H. M. de Visser1, K. Coeleveld1, C. Steen-Louws2, C. E. Hack2, H. Weinans3, F. P. Lafeber1, S. C. Mastbergen1; 1Rheumatology & Clinical

Immunology, Univ. Med. Ctr. Utrecht, Utrecht, Netherlands, 2Lab. of Translational Immunology, Univ. Med. Ctr. Utrecht, Utrecht, Netherlands, 3Dept.s of Orthopedics and Rheumatology, Univ. Med. Ctr. Utrecht, Utrecht, Netherlands

549 MESENCHYMAL STEM CELL ENCAPSULATION IN ALGINATE MICRO-PARTICLES FOR INTRA-ARTICULAR INJECTION IN OSTEOARTHRITIS A. Smith1,2, A. Des Rieux2,3, M. Marquis4, D. Renard4, C. Vinatier1, J. Guicheux1,5, C. Le Visage1; 1RMeS, Regenerative Med. and Skeleton, Université de Nantes, ONIRIS,

nantes, France, 2LDRI, ADDB, Université Catholique de Louvain, Bruxelles, Belgium, 3Inst. of Condensed Matter and NanoSci.s, Université Catholique de Louvain, Louvain-la-Neuve, Belgium, 4UR1268 BIA (Biopolymères Interactions Assemblages), INRA, nantes, France, 5CHU Nantes, PHU 4 OTONN, Nantes, France

550 RESULTS FROM A 52-WEEK RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 STUDY OF A NOVEL, INTRA-ARTICULAR WNT PATHWAY INHIBITOR (SM04690) FOR THE TREATMENT OF KNEE OSTEOARTHRITIS

Y. Yazici1, T. E. McAlindon2, A. Gibofsky3, N. E. Lane4, D. J. Clauw5, M. H. Jones6, J. Bergfeld6, C. J. Swearingen1, A. DiFrancesco1, J. R. Tambiah1, M. Hochberg7; 1Samumed, San Diego, CA, 2Tufts Med. Ctr., Boston, MA, 3Weill Cornell Med. and Hosp. for Special Surgery, New York, NY, 4UC Davis Med. Ctr., Davis, CA, 5Univ. of Michigan, Ann Arbor, MI, 6Cleveland Clinic, Cleveland, OH, 7Univ. of Maryland Sch. of Med., Baltimore, MD

551 INTRA-ARTICULAR SPRIFERMIN REDUCES CARTILAGE LOSS IN ADDITION TO INCREASING CARTILAGE GAIN INDEPENDENT OF FEMOROTIBIAL LOCATION: A POST-HOC ANALYSIS OF A RANDOMIZED, PLACEBO-CONTROLLED PHASE II CLINICAL TRIAL

F. Eckstein1, S. Wax2, A. Aydemir2, W. Wirth1, S. Maschek1, M. Hochberg3; 1Inst. of Anatomy, Paracelsus Med. Univ. Salzburg & Nuremberg, Salzburg, Austria, 2EMD Serono, Billerica, MA, 3Univ. of Maryland Sch. of Med., Baltimore, MD

552 EFFICACY OF INTRA-ARTICULAR HYPERTONIC DEXTROSE PROLOTHERAPY VERSUS NORMAL SALINE FOR KNEE OSTEOARTHRITIS: A TRIPLE-BLINDED RANDOMIZED CONTROLLED TRIAL

R. SIT1, R. WU1, D. Rabago2, K. Reeves3, D. Chan1, B. Yip1, V. Chung1, S. Wong1; 1The Chinese Univ. of Hong Kong, Hong Kong, Hong Kong, 2The Univ. of Wisconsin, Madison, WI, 3Pain Med. and Rehabilitation (private), Kansas, MO

553 POTENTIAL ANTI-INFLAMMATORY MECHANISM OF ACTION OF MESENCHYMAL STROMAL CELLS IN OSTEOARTHRITIS PATIENTS RESULTS IN OVERALL IMPROVEMENT IN PAIN AND SYMPTOMS

A. Chaboureau1, S. Bhatt1, A. Gómez-Aristizábal1, J. Chisholm1, W. Amanda1, A. Fazio1, M. Kapoor1, A. Keating1,2, D. Ogilvie-Harris1, N. Mahomed1, R. Gandhi1, W. Marshall1, K. Syed1, A. Naraghi3, J. Chahal1, S. Viswanathan1,2; 1Univ. Hlth.Network - Arthritis Program, Toronto, ON, Canada, 2Univ. of Toronto - Inst. of Biomaterials and BioMed. Engineering, Toronto, ON, Canada, 3Univ. Hlth.Network - Joint Dept. of Med. Imaging, Toronto, ON, Canada

554 LOCAL ADMINISTERED ADIPOSE-DERIVED MESENCHYMAL STROMAL CELLS REDUCE EXPERIMENTAL OA-PATHOLOGY VIA INTERLEUKIN-1β-MEDIATED IMMUNOMODULATION OF PRO-INFLAMMATORY PMNS

S. van Dalen1, M. van den Bosch1, A. Sloetjes1, L. Casteilla2, A. Blom1, P. van Lent1; 1Radboud Univ. Med. Ctr. Nijmegen, Nijmegen, Netherlands, 2UMR STROMAlab, Toulouse, France

THERAPY – STEM CELL555 LARGE-SCALE SECRETOME ANALYSES OF MESENCHYMAL STROMAL CELLS FROM ADULT JOINT TISSUES AND UMBILICAL CORD: AN IN

VITRO COMPARATIVE STUDY TO UNVEIL THEIR IMMUNOREGULATORY POTENTIAL A. Islam1, I. Urbarova2, I. Martinez-Zubiaurre1; 1Inst. of Clinical Med., Univ. of Tromsø, Tromsø, Norway, 2Proteomics Platform, Univ. of Tromsø, Tromsø, Norway

556 CD317 PROFILING DISTINGUISHES BONE MARROW STROMAL CELL SUBTYPES WITH DISTINCT FUNCTIONAL IMPACT UPON T CELL PROLIFERATION AND POLARISATION

A. G. Kay, A. Stone, J. M. Fox, P. G. Genever; Univ. of York, York, United Kingdom

557 MESENCHYMAL STEM CELL THERAPY FOR OSTEOARTHRITIS: HOW APOPTOTIC CELLS MODULATE INFLAMMATION P. Mancuso, A. J. Burke, S. Raman, A. E. Ryan, T. Ritter, F. Barry, M. J. Murphy; REMEDI (NUI Galway), Galway, Ireland

558 MESENCHYMAL STEM CELLS PRODUCED EXOSOMES AND MICROPARTICLES THAT EXERT A SIMILAR CHONDROPROTECTIVE EFFECT IN OSTEOARTHRITIS

S. Cosenza, M. Ruiz, K. Toupet, C. Bony, C. Jorgensen, D. Noel; Inserm U1183, Montpellier, France

64 | FINAL PROGRAM

559 ESTABLISHMENT OF AN INDUCED PLURIPOTENT STEM CELL-LINE FROM HAND OSTEOARTHRITIC PATIENTS R. CASTRO-VIÑUELAS, Sr.1, C. SANJURJO-RODRÍGUEZ, Sr.1, M. PIÑEIRO-RAMIL, Sr.1, T. HERMIDA-GÓMEZ, Sr.2, I. FUENTES-BOQUETE, Sr.1,

J. DE TORO-SANTOS, Sr.1, F. BLANCO-GARCÍA, Sr.3, S. DÍAZ PRADO, Sr.1; 1UNIVERSIDADE DA CORUÑA, A CORUÑA, Spain, 2INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE A CORUÑA, A CORUÑA, Spain, 3INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE A ACORUÑA, A CORUÑA, Spain

560 DUAL FGF-2 AND SOX9 GENE TRANSFER VIA RAAV VECTORS: EFFECTS ON THE CHONDROGENIC AND METABOLIC PROCESSES IN HUMAN BONE MARROW ASPIRATES

K. TAO, Sr.1,2, A. Rey-Rico2, J. K. Venkatesan2, G. Schmitt2, H. Madry2,3, J. Lin4, M. Cucchiarini2; 1Peking Univ. People’s Hosp., Beijing, China, 2Ctr. of Experimental Orthopedics, Saarland Univ. Med. Ctr., Homburg/Saar, Germany, 3Dept. of Orthopaedic Surgery, Saarland Univ. Med. Ctr., Homburg/Saar, Germany, 4Inst. of Arthritis, Peking Univ. People’s Hosp., Beijing, China

561 COMPARISION BETWEEN HUMAN AMNIOTIC FLUID AND ADIPOUS TISSUE MESENCHYMAL STEM CELLS INDUCED-CHONDROGENESIS CULTURED IN CHITOSAN-XANTHAN SCAFFOLD STIMULATED WITH TGF-β3

I. I. DAMAS, C. C. ZULIANI, A. M. MORAES, C. B. WESTIN, P. KHARMANDAYAN, K. C. ANDRADE, R. L. MAMONEI, I. B. COIMBRA; STATE Univ. OF CAMPINAS, CAMPINAS, Brazil

562 RESPONSE TO TANEZUMAB, AS ASSESSED BY OUTCOME MEASURES IN RHEUMATOLOGY-OSTEOARTHRITIS RESEARCH SOCIETY INTERNATIONAL CRITERIA, IN PATIENTS WITH OSTEOARTHRITIS OF THE KNEE OR HIP

T. J. Schnitzer1, A. E. Bello2, C. R. West3, G. C. Pixton4, L. Tive5; 1Northwestern Univ. Feinberg Sch. of Med., Chicago, IL, 2Illinois Bone and Joint Inst., Glenview, IL, 3Pfizer Inc, Groton, CT, 4Pfizer Inc, Morrisville, NC, 5Pfizer Inc, New York, NY

THERAPY – BIOLOGICAL563 STRUCTURAL AND SYMPTOMATIC BENEFIT OF A HALF-LIVE EXTENDED, SYSTEMICALLY APPLIED ANTI-ADAMTS-5 INHIBITOR (M6495) C. Brenneis1, B. Serruys2, T. Van Belle2, S. Poelmans2, K. Kleinschmidt-Doerr1, H. Guehring1, M. Michaelis1, S. Lindemann1; 1Merck Biopharma, Darmstadt,

Germany, 2Ablynx, Zwijnaarde, Belgium

564 THE EFFICACY AND SAFETY OF GENETICALLY ENGINEERED ALLOGENEIC HUMAN CHONDROCYTES EXPRESSING TGF-β1 IN PATIENTS WITH GRADE 3 CHRONIC DEGENERATIVE JOINT DISEASE OF THE KNEE

G. Kalsi1, J. Parvizi2, D. Bramlet3, D. Romness4, A. Guermazi5, M. Noh6, A. Khlopas7, M. A. Mont7; 1TissueGene, Inc., Rockville, MD, 2Rothman Inst., Philadelphia, PA, 3Pinellas Park, Pinellas Park, FL, 4Commonwealth Orthopedics, Arlington, VA, 5Boston Univ., Boston, MA, 6TissueGene Inc., Rockville, MD, 7Cleveland Clinic, Cleveland, OH

565 TUMOR NECROSIS FACTOR-INHIBITOR TREATMENT DURATION IS ASSOCIATED WITH LOWER RISK OF HAND OSTEOARTHRITIS PROGRESSION IN PATIENTS WITH RECENT-ONSET RHEUMATOID ARTHRITIS AFTER 10-YEAR FOLLOW-UP

M. Loef1, F. P. Kroon1, S. A. Bergstra1, J. A. van der Pol1, W. F. Lems2, P. J. Kerstens3, C. F. Allaart1, M. Kloppenburg1; 1Leiden Univ. Med. Ctr., Leiden, Netherlands, 2VU Med. Ctr., Amsterdam, Netherlands, 3Westfriesgasthuis, Hoorn, Netherlands

566 YAP TARGETING IN SYNOVIAL MSCs AS A NOVEL THERAPEUTIC APPROACH FOR OSTEOARTHRITIS F. Colella1, Y. Cai2, K. Howard2, A. Roelofs1, C. De Bari1; 1Arthritis and Regenerative Med. Lab., Inst. of Med. Sci., Univ. of Aberdeen, Aberdeen, United Kingdom,

2Interdisciplinary NanoSci. Ctr. (iNANO), Dept. of Molecular Biology and Genetics, Aarhus Univ., Aarhus, Denmark

567 LOCAL ANTI-INFLAMMATORY COMBINATION TREATMENT OF EXPERIMENTAL OA BASED ON INJECTABLE GELS C. Aulin, K. Palmblad, L. Klareskog, H. E. Harris; Karolinska Inst., Stockholm, Sweden

568 BONE MARROW CONCENTRATE THERAPY IMPROVES SHORT-TERM OUTCOMES IN PATIENTS WITH SYMPTOMATIC HIP OSTEOARTHRITIS K. E. Whitney, K. K. Briggs, I. K. Bolia, M. J. Philippon, T. A. Evans; Steadman Philippon Res. Inst., Vail, CO

569 LONG-TERM EFFECTS OF VITAMIN D SUPPLEMENTATION AND MAINTAINING VITAMIN D SUFFICIENCY ON KNEE OSTEOARTHRITIS OVER 5 YEARS

B. Antony1, S. Zheng1, J. Burgess2, C. Ding1; 1Univ. of Tasmania, Hobart, Australia, 2Royal Hobart Hosp., Hobart, Australia

65 | FINAL PROGRAM

THERAPY – PHARMACOLOGIC570 PHARMACOTHERAPEUTIC TREATMENT PARADIGMS OF OSTEOARTHRITIS IN THE UNITED STATES M. A. Mychaski1, L. Abraham2, J. C. Cappelleri3, A. Bushmakin4, L. Tive3, L. Viktrup1, N. Williams5, J. Mellor6, J. Jackson5; 1Eli Lilly and Co, Indianapolis, IN, 2Pfizer

Inc, Tadworth, Surrey, United Kingdom, 3Pfizer Inc, New York, NY, 4Pfizer Inc, Pelham, NH, 5Adelphi Group, Bollington, Cheshire, United Kingdom, 6Adelphi Group, Glossop, Derbyshire, United Kingdom

571 SUSTAINED INTRA-ARTICULAR DELIVERY OF CYCLIN-DEPENDENT KINASE 9 INHIBITORS PROTECTS AGAINST PROTEOLYTIC ACTIVITY IN AN ACL RUPTURE RAT MODEL OF PTOA

A. Bolandparvaz1, J. H. Yik2, J. Lewis1, D. R. Haudenschild2; 1Univ. of California Davis, Davis, CA, 2Univ. of California Davis, Sacramento, CA

572 BISPHOSPHONATE INTAKE AND TIBIOFEMORAL OSTEOARTHRITIS-RELATED OSSEOUS STRUCTURAL DAMAGE: DATA FROM THE FOUNDATION FOR THE NATIONAL INSTITUTE OF HEALTH OSTEOARTHRITIS BIOMARKERS CONSORTIUM

A. Haj-Mirzaian1, N. Hafezi-Nejad2, A. Guermazi3, C. Bingham1, D. Vaidya1, F. Roemer3, T. Brown1, S. Demehri1; 1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, 2Univ. System of Maryland, Baltimore, MD, 3Boston Univ. Sch. of Med., Boston, MA

573 BISPHOSPHONATES INTAKE AND ITS ASSOCIATION WITH CHANGES OF PERIARTICULAR BONE AREA AND THREE-DIMENSIONAL SHAPE: DATA FROM THE OSTEOARTHRITIS INITIATIVE (OAI)

A. Haj-Mirzaian1, A. Guermazi2, F. Roemer2, M. Bowes3, P. Conaghan4, S. Demehri1; 1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, 2Boston Univ. Sch. of Med., Boston, MA, 3Imorphics Ltd, Kilburn House, Manchester, United Kingdom, 4Univ. of Leeds & NIHR Leeds BioMed. Res. Ctr., Leeds, United Kingdom

574 EFFECT OF VITAMIN D THERAPY ON SYNOVIAL TISSUE VOLUME AND BONE MARROW LESIONS IN SYMPTOMATIC KNEE OSTEOARTHRITIS T. A. Perry1, T. W. O’Neill1,2, M. J. Parkes1, D. T. Felson3,1, R. Hodgson1, N. K. Arden4; 1The Univ. of Manchester, Manchester, United Kingdom, 2Salford Royal

NHS Fndn. Trust, Manchester, United Kingdom, 3Boston Univ., Boston, MA, 4The Univ. of Oxford, Oxford, United Kingdom

575 IMPACT OF ANTIDIABETIC DRUGS ON OSTEOARTHRITIS IN PATIENTS WITH DIABETES: DATA FROM THE OSTEOARTHRITIS INITIATIVE J. Neumann1, U. Heilmeier1, G. B. Joseph1, F. C. Hofmann1, W. Ashmeik1, M. C. Nevitt2, C. E. McCulloch2, N. E. Lane3, J. A. Lynch2, T. M. LINK1; 1UCSF Dept.

of Radiology & BioMed. Imaging, San Francisco, CA, 2UCSF Dept. of Epidemiology and Biostatistics, San Francisco, CA, 3UC Davis Dept. of Med. and Ctr. for Musculoskeletal Hlth., Sacramento, CA

576 EFFECT OF COLCHICINE ON INFLAMMATION-MEDIATING CYTOKINES IN HUMAN OSTEOARTHRITIC CHONDROCYTES (IN-VITRO MODEL) M. Singh1, S. Pal2, U. Dhakad1, R. Srivastava1, N. Chattopadhyay2, S. K. Das1; 1K.G. Med. Univ., Lucknow, India, 2Central Drug Res. Inst., Lucknow, India

577 FOR HOW LONG DO ORAL NSAIDS IMPROVE SYMPTOMS IN KNEE OSTEOARTHRITIS? A SYSTEMATIC REVIEW AND META-ANALYSIS M. C. Osani, E. E. Vaysbrot, R. R. Bannuru, T. E. McAlindon; Tufts Med. Ctr., Boston, MA

578 THE EFFECT OF DIFFERENT TREATMENTS ON THE CLINICAL COURSE OF KNEE OSTEOARTHRITIS E. Trofimov, A. Trofimova, V. Mazurov; North-Western State Med. Univ. named after I.I.Mechnikov, Saint-Petersburg, Russian Federation

579 COMPARISON OF SERUM AND SYNOVIAL FLUID IL-1β, IL-18, TNF-α AND CASPASE-1 LEVELS BETWEEN OA KNEE PATIENTS TAKING COLCHICINE VS NSAIDS

R. R. Sahoo, U. Dhakad, R. Srivastava, M. Singh, S. K. Das; K.G. Med. Univ., Lucknow, India

580 EFFICACY AND SAFETY OF KNEE OSTEOARTHRITIS TREATMENT WITH KETOROLAC TROMETAMINE GEL IN ELDERLY PATIENTS V. Povoroznyuk, N. Grygorieva, M. Bystrytska, T. Kovtun, A. Pidlisetskiy; D.F. Chebotarev Inst. of Gerontology NAMS Ukraine, Kyiv, Ukraine

581 CR4056, A FIRST-IN-CLASS IMIDAZOLINE-2 RECEPTOR LIGAND ANALGESIC, IN PAIN FROM KNEE OSTEOARTHRITIS PHENOTYPES: A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, PHASE IIA CLINICAL TRIAL

L. Rovati1, N. J. Probert2, T. Blicharski3, N. Brambilla1, C. Vitalini1, F. Girolami1, G. Giacovelli1, M. D’Amato1; 1Rottapharm Biotech, Monza, Italy, 2MAC Clinical Res., Manchester, United Kingdom, 3Lubelskie Centrum Diagnostyczne, Świdnik, Poland

582 FACTORS ASSOCIATED WITH DEPRESSION AND EFFECTS OF VITAMIN D SUPPLEMENTATION AND MAINTAININGVITAMIN D SUFFICIENCY ON DEPRESSION IN PATIENTS WITH KNEE OSTEOARTHRITIS

s. zheng1, L. Tu2, F. Cicuttini3, W. Han1, Z. Zhu1, B. Antony1, A. Wluka3, T. Winzenberg1,4, D. Aitken1, L. Blizzard1, G. Jones1, C. Ding1,5; 1Menzies Inst. for Med. Res., Univ. of Tasmania, Hobart, Australia, 2Dept. of Rheumatology, the third Affiliated Hosp. of SUN YAT-SEN Univ., Guangzhou, China, 3Dept. of Epidemiology and Preventive Med., Monash Univ., Melbourne, Australia, 4Faculty of Hlth., Univ. of Tasmania, Hobart, Australia, 5Sch. of Basic Med. Sci., Southern Med. Univ., Guangzhou, China

66 | FINAL PROGRAM

583 EFFICACY OF ZOLEDRONATE IN TREATING OSTEONECROSIS OF THE FEMORAL HEAD: A RANDOMIZED CONTROLLED TRIAL M. Cross1, M. Macara1, E. Little1, M. Chan2, D. Little3, R. Buchbinder4, C. L. Hill5, E. Duncan6, C. Inderjeeth7, G. Major8, P. Sambrook (dec)1, L. March1; 1Univ. of Sydney,

St Leonards, Australia, 2Royal North Shore Hosp., St Leonards, Australia, 3The Children’s Hosp. Westmead, Univ. of Sydney, Sydney, Australia, 4Cabrini Hosp., Monash Univ., Melbourne, Australia, 5The Queen Elizabeth Hosp., Univ. of Adelaide, Adelaide, Australia, 6Royal Brisbane and Womens’ Hosp., Univ. of Queensland, Brisbane, Australia, 7Sir Charles Gairdner Hosp., Univ. of Western Australia, Perth, Australia, 8Royal Newcastle Ctr., Univ. of Newcastle, Newcastle, Australia

584 ADAMTS-5 INHIBITOR GLPG1972, A POTENTIAL NEW TREATMENT IN OSTEOARTHRITIS, SHOWS FAVORABLE SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS IN HEALTHY SUBJECTS

E. M. van der Aar1, J. Desrivot2, L. Fagard1, D. Amantini2, S. Larsson3, A. Struglics3, S. Lohmander3, F. Vanhoutte1, S. Dupont2; 1Galapagos NV, Mechelen, Belgium, 2Galapagos SASU, Romainville, France, 3Orthopaedics, Dept. of Clinical Sci., Lund Univ., Lund, Sweden

585 CLINICAL RESEARCH ON ELECTRICAL ACUPOTOMY TO “NODAL POINT” TREATING KNEE OSTEOARTHRITIS J. Yao, Jr.1, B. Dong, Sr.2, O. Guofeng, Sr.1, L. Xiaoqun, Sr.3, Y. Puwei, Sr.1, L. Deyu, Sr.3; 1Shaanxi Univ. of traditional Chinese Med., XianYang, China, 2Affiliated

Hosp. of Shaanxi Univ. of traditional Chinese Med., XianYang, China, 3Affiliated Hosp. of Shaanxi Univ. of Traditional Chinese Med., XianYang, China

THERAPY – NON-PHARMACOLOGIC586 EDUCATIONAL PROGRAM IMPROVES FUNCTION, STRENGTH AND QUALITY OF LIFE. TWO-YEAR RESULTS OF PARVE II (PROJECT

ARTHRITIS RECOVERING QUALITY OF LIFE BY THROUGH EDUCATION). M. U. Rezende, N. L. Brito, M. I. Hissadomi, A. F. Pailo, R. Frucchi, T. Pasqualin, F. E. Farias, C. A. Silva, C. H. Cernigoy, O. F. Santana, M. M. Marins, O. P.

Camargo; Faculdade Med. USP, Sao Paulo, Brazil

587 BASED ON MECHANICAL STIMULATION OF MUSCLE AND LIGAMENT GROWTH MECHANICS BALANCE AND ADAPTATION : A CLINICAL STUDY ON ACUPOTOMY PREVENTING AND TREATING DEGENERATIVE JOINT DISEASE

G. Ou1, F. Yin2, B. Do3, X. Li3, J. Liu1, T. Zhu1, P. Yuan2, D. Liu2; 1Shaanxi Univ. of Traditional Chinese Med., Shaanxi Xianyang, China, 2Affiliated Hosp. of Shaanxi Univ. of Traditional Chinese Med., Shaanxi Xianyang, China, 3Affiliated Hosp. of Shaanxi Univ. of Traditional Chinese Med., Shaanxi Xianyang, China

588 6- AND 12-MONTH RESULTS OF A PROSPECTIVE, MULTI-CENTER, RANDOMIZED, TRIAL COMPARING SAFETY AND EFFECTIVENESS OF COOLED RADIOFREQUENCY ABLATION TO CORTICOSTEROID INJECTION FOR MANAGEMENT OF OSTEOARTHRITIC KNEE PAIN

M. J. Desai1, T. Davis2, E. Loudermilk3, M. DePalma4, C. Hunter5, D. Lindley6, N. Patel7, D. Choi8, M. Soloman9, A. Gupta10, A. Buvanendran11, L. Kapural12; 1Intl. Spine, Pain & Performance Ctr., Washington, DC, 2Orthopedic Pain Specialists, Santa Monica, CA, 3Piedmont Comprehensive Pain Management Group, Greenville, SC, 4Virginia iSpine Physicians, Richmond, VA, 5Ainsworth Inst. of Pain, New York, NY, 6Interventional Pain Management of Texas, Mineral Wells, TX, 7Advanced Pain Management, Greenfield, WI, 8Valley Pain Consultants, Scottdale, AZ, 9Valley Anesthesia Consultantsr, Phoenix, AZ, 10Drexel Univ., Philadelphia, PA, 11Rush Univ. Med. Ctr., Chicago, IL, 12Ctr. for Clinical Res., Winston-Salem, NC

589 TAI CHI VERSUS PHYSICAL THERAPY FOR KNEE OSTEOARTHRITIS: A COST-EFFECTIVENESS ANALYSIS J. B. Wong1, M. Chung2, L. Price1, C. Wang1; 1Tufts Med. Ctr., Boston, MA, 2Tufts Univ. Sch. of Med., Boston, MA

590 CHONDROGENIC POTENCIAL OF STANDARDISED PLATELET RICH PLASMA ON OSTEOARTHRITIC MESENCHYMAL STROMAL CELLS L. Gato-Calvo1,2, T. Hermida-Gomez1,2, J. Magalhaes1,2, C. Ruiz-Romero3,4, F. J. Blanco1,2, E. F. Burguera1,2; 1Unidad de Med. Regenerativa, Grupo de Investigación

en Reumatología (GIR), Inst. de Investigación Biomédica de A Coruña, A Coruña, Spain, 2Centro de Investigaciones Científicas Avanzadas (CICA), Univ. de A Coruña (UDC), A Coruña, Spain, 3Unidad de Proteómica, Grupo de Investigación en Reumatología (GIR), Inst. de Investigación Biomédica de A Coruña, A Coruña, Spain, 4CIBER-BBN, Madrid, Spain

591 IMPACT OF KNEE JOINT LOADING EXERCISE ON MRI-ASSESSED ARTICULAR CARTILAGE IN PEOPLE AT RISK OF, OR WITH ESTABLISHED, KNEE OSTEOARTHRITIS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS

A. Bricca1, C. B. Juhl1,2, M. Steultjens3, W. Wirth4,5, E. M. Roos1; 1Univ. of Southern Denmark, Odense, Denmark, 2Univ. of Copenhagen, Herlev and Gentofte Hosp., Copenhagen, Denmark, 3Glasgow Caledonian Univ., Glasgow, United Kingdom, 4Paracelsus Med. Univ. (PMU) Salzburg and Nuremberg, Salzburg,, Salzburg, Austria, 5Chondrometrics GmbH - Med. Data Processing, Ainring, Germany

592 IMPACT OF EXERCISE THERAPY ON MOLECULAR BIOMARKERS RELATED TO ARTICULAR CARTILAGE AND INFLAMMATION IN PEOPLE AT RISK OF, OR WITH ESTABLISHED, KNEE OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

A. Bricca1, A. Struglics2, S. Larsson3, M. Steultjens4, C. B. Juhl1,5, E. M. Roos1; 1Univ. of Southern Denmark, Odense, Denmark, 2Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Lund, Sweden, 3Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopaedics, Odense, Sweden, 4Glasgow Caledonian Univ., Glasgow, United Kingdom, 5Univ. of Copenhagen, Herlev and Gentofte Hosp., Copenhagen, Denmark

593 JOINT ACADEMY - A SIX-WEEK ONLINE TREATMENT PROGRAM FOR OSTEOARTHRITIS H. Nero1, J. Dahlberg2, L. E. Dahlberg1; 1Lund Univ., Dept. of Orthopaedics, Lund, Sweden, 2Arthro Inc., Malmö, Sweden

67 | FINAL PROGRAM

594 THE EFFECTS OF EXERCISE ON SYNOVITIS AND BONE MARROW LESIONS IN KNEE OSTEOARTHRITIS: SECONDARY OUTCOMES FROM A RANDOMIZED CONTROLLED TRIAL

E. Bandak1, M. Boesen2, H. Bilddal1, C. Daugaard1, S. Hangaard1, C. Bartholdy1, J. D. Nybing3, M. Henriksen1,4; 1The Parker Inst., Copenhagen Univ. Hosp., Bispebjerg and Frederiksberg, Copenhagen F, Denmark., Denmark, 2Dept. of Radiology, Copenhagen Univ. Hosp., Bispebjerg and Frederiksberg, Copenhagen F, Denmark., Denmark, 3Dept. of Radiology, Copenhagen Univ. Hosp. Bispebjerg and Frederiksberg, Copenhagen F, Denmark., Denmark, 4Dept. of physical and occupational therapy, Copenhagen Univ. Hosp., Bispebjerg and Frederiksberg, Copenhagen F, Denmark., Denmark

595 DOES BASELINE PHYSICAL ACTIVITY LEVEL IMPACT ON CHANGE IN KNEE PAIN FOLLOWING PATIENT EDUCATION AND SUPERVISED EXERCISE THERAPY? A PROSPECTIVE COHORT STUDY OF 12,800 PARTICIPANTS WITH KNEE OA FROM THE DANISH GLA:D® REGISTRY

A. Bricca1, S. T. Skou1,2, E. M. Roos1; 1Univ. of Southern Denmark, Odense, Denmark, 2Dept. of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Denmark

596 IMPLEMENTATION OF GOOD LIFE WITH OSTEOARTHRITIS FROM DENMARK (GLA:DTM) IN CHINA: THE PILOT RESULTS AND A SURVEY ON PATIENT VIEWS AND PREFERENCES

Q. Liu1, K. Wang1, W. Zhang1, Z. Zhou1, X. Xing1, S. An1, S. Gao1, Y. Hou1, E. M. Roos2, J. Lin1; 1Peking Univ., Beijing, China, 2Univ. of Southern Denmark, Odense, Denmark

597 MANUAL THERAPY FOR KNEE OSTEOARTHRITIS PAIN: A SYSTEMATIC REVIEW AND META-ANALYSIS B. Chen1, H. Zhan1, J. Marszalek2, M. Chung3, X. Lin1, R. Bannuru2, C. Wang2; 1Shuguang Hosp. affiliated to Shanghai Univ. of Traditional Chinese Med., Shanghai,

China, 2Tufts Med. Ctr., Boston, MA, 3Tufts Univ., Boston, MA

598 CHANGES IN SUBCHONDRAL BONE STATUS, CARTILAGE AND SYNOVIAL MEMBRANE IN RESPONSE TO CHIROPRACTIC MANIPULATION IN AN OSTEOARTHRITIS MODEL

F. M. Conesa-Buendía1, R. Fujikawa, Sr.2, A. Mediero, Sr.1, P. Gratal1, F. Mulero, Sr.3, A. Ortega-De Mues, Sr.1; 1Bone and Joint Res. Unit, IIS-Fundación Jiménez Díaz, Madrid, Spain, 22Madrid Coll. of Chiropractic-Real Centro Univ.rio Escorial-María Cristina, Madrid, Spain, 3Molecular Image Unit, Centro Natl. de Investigaciones Oncológicas (CNIO), Madrid, Spain

599 THE ABC FOOT STUDY: AN INTERNATIONAL, MULTI-PHASE, MIXED METHODS STUDY OF THE ASSESSMENT OF BELIEFS AND CLINICAL PRACTICE FOR MANAGING FIRST METATARSOPHALANGEAL JOINT OSTEOARTHRITIS

K. L. Paterson1, R. S. Hinman1, H. B. Menz2, K. L. Bennell1; 1The Univ. of Melbourne, Carlton, Australia, 2La Trobe Univ., Bundoora, Australia

600 CHANGE IN ACTIVITY FOLLOWING ADMINISTRATION OF A LATERAL WEDGE INSOLE: ANALYSIS FROM THE INRESPOND TRIAL M. J. Parkes1,2, R. K. Jones3,2, S. C. Carter1,2, A. Liu3, M. J. Callaghan4,2, D. T. Felson5,1; 1The Univ. of Manchester, Manchester, United Kingdom, 2Manchester

Academic Hlth.Sci. Ctr., Manchester, United Kingdom, 3The Univ. of Salford, Salford, United Kingdom, 4Manchester Metropolitan Univ., Manchester, United Kingdom, 5Boston Univ., Boston, MA

601 6- AND 12-MONTHS FOLLOW-UP OF A RANDOMIZED CONTROLLED TRIAL ON LAND-BASED EXERCISE THERAPY IN HIP OA. A SECONDARY PER PROTOCOL ANALYSIS FOR PAIN AND PHYSICAL FUNCTIONING.

I. Roesel, P. Martus, D. Haigis, I. Krauss; Univ. Hosp. Tübingen, Tübingen, Germany

602 EXERCISE DOSE-RESPONSE IN INDIVIDUALS PARTICIPATING IN A SUPPORTED OSTEOARTHRITIS SELF-MANAGEMENT PROGRAM; AN OBSERVATIONAL REGISTER STUDY

T. Jönsson, H. Nero, L. E. Dahlberg; Univ. of Lund, Lund, Sweden

603 KNEE OSTEOARTHRITIS AND COMORBIDITY: A FEASIBILITY STUDY ON AN INTERACTIVE EXERCISE THERAPY COURSE FOR PHYSIOTHERAPISTS M. de Rooij1, M. van der Leeden1,2, M. van der Esch1,3, W. F. Lems4, J. Meesters5, L. D. Roorda1, M. Terbraak3, T. Vredeveld3, T. P. Vliet Vlieland5, J. Dekker2;

1Reade, Ctr. for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 2VU Med. Ctr., Dept. of Rehabilitation, Amsterdam, Netherlands, 3ACHIEVE Ctr. of Expertise, Faculty of Hlth., Amsterdam Univ. of Applied Sci., Amsterdam, Netherlands, 4VU Med. Ctr., Dept. of Rheumatology, Amsterdam, Netherlands, 5Leiden Univ. Med. Ctr. (LUMC), Dept. of Orthopedics, Leiden, Netherlands

604 STRATIFIED EXERCISE THERAPY BY PHYSICAL THERAPISTS IN PRIMARY CARE IS FEASIBLE IN PATIENTS WITH KNEE OSTEOARTHRITIS J. Knoop1, M. van der Leeden1,2, M. van der Esch1, M. de Rooij1, W. F. Peter1, K. L. Bennell3, M. P. Steultjens4, A. Hakkinen5, L. D. Roorda1, W. F. Lems1,2, J.

Dekker2; 1Reade, centre for rehabilitation and rheumatology, Amsterdam, Netherlands, 2VU Univ. Med. Ctr., Amsterdam, Netherlands, 3Univ. of Melbourne, Melbourne, Australia, 4Glasgow Caledonian Univ., Glasgow, United Kingdom, 5Univ. of Jyvaskyla, Jyvaskyla, Finland

605 A MIXED METHODS EXPLORATION OF HOW UK PHYSICAL THERAPISTS ADDRESS WEIGHT LOSS AMONG INDIVIDUALS WITH HIP OSTEOARTHRITIS.

M. A. Holden1, J. Waterfield1, R. Whittle1, K. Bennell2, L. Chesterton1, J. G. Quicke1, C. D. Mallen1; 1Keele Univ., Keele, United Kingdom, 2The Univ. of Melbourne, Melbourne, Australia

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606 SYSTEMATIC REVIEW OF CLINICAL PRACTICE GUIDELINES ON EXERCISE THERAPY FOR KNEE OSTEOARTHRITIS AND CRITICAL APPRAISAL USING AGREEII INSTRUMENT

Y. Hou1, Z. Yang1, J. Lin1, Y. Chen2, D. Xing1, B. Wang3; 1Peking Univ. People’s Hosp., Beijing, China, 2GRADE center China), Lanzhou Univ., Lanzhou, China, 3Shanxi Med. Univ. 2nd Affiliated Hosp., Orthopaedic Dept., Taiyuan, China

607 VALUE AND PREFERENCE TOWARDS EXERCISE THERAPY: A CROSS-SECTIONAL STUDY AMONG CHINESE PATIENTS WITH KNEE OSTEOARTHRITIS

W. Zhang1, Y-f. Hou1, D. Xing1, Y. Zhang2, Z-y. Yang1, Y-l. Chen3, J-h. Lin1; 1Peking Univ. People’s Hosp., Beijing, China, 2McMaster Univ., Hamilton, ON, Canada, 3Lanzhou Univ., Lanzhou, China

608 IMPACT OF A SELF-CARE EDUCATION PROGRAM FOR PATIENTS WITH OSTEOARTHRITIS A. Gurt1, J. Llorente2, M. López2, L. Tío2, B. Sena1, E. Marco2, F. Montañés1, J. Vergés3, M. Herrero4, J. Monfort2; 1CAP Vila Olímpica, Barcelona, Spain, 2Parc de

Salut Mar, Barcelona, Spain, 3OAFI Fndn., Barcelona, Spain, 4Bioibérica S.A.U., Barcelona, Spain

609 SUBGROUPING AND TARGETED EXERCISE PROGRAMMES FOR KNEE AND HIP OSTEOARTHRITIS (STEER OA): AN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS INITIATIVE

M. A. Holden1, D. L. Burke1, J. Runhaar2, D. van Der Windt1, R. D. Riley1, K. Dziedzic1, A. Legha1, A. L. Evans1, J. H. Abbott3, K. Baker4, J. Brown1, K. L. Bennell5, D. Bossen6, L. Brosseau7, K. Chaipinyo8, R. Christensen9, T. Cochrane10, M. de Rooij11, M. Doherty12, H. P. French13, S. Hickson1, R. S. Hinman5, M. Hopman-Rock14, M. V. Hurley15, C. Ingram1, J. Knoop11, I. Krauss16, C. McCarthy17, S. P. Messier18, D. L. Patrick19, N. Sahin20, L. A. Talbot21, R. Taylor1, C. H. Teirlinck2, M. van Middelkoop2, C. Walker1, N. E. Foster1, The OA Trial Bank; 1Keele Univ., Keele, United Kingdom, 2Erasmus Univ. Med. Ctr., Rotterdam, Netherlands, 3Univ. of Otago, Dunedin, New Zealand, 4Boston Univ., Boston, MA, 5Univ. of Melbourne, Melbourne, Australia, 6Univ. of Amsterdam, Amsterdam, Netherlands, 7Univ. of Ottawa, Ottawa, ON, Canada, 8Srinakharinwirot Univ., Bangkok, Thailand, 9Bispebjerg and Frederiksberg Hosp., Copenhagen, Denmark, 10Univ. of Canberra, Canberra, Australia, 11Ctr. for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 12Univ. of Nottingham, Nottingham, United Kingdom, 13Royal Coll. of Surgeons in Ireland, Dublin, Ireland, 14TNO Netherlands Organisation for Applied Scientific Res., Leiden, Netherlands, 15St George’s Univ. of London and Kingston Univ., London, United Kingdom, 16Univ. Hosp. of Tübingen, Tübingen, Germany, 17Manchester Metropolitan Univ., Manchester, United Kingdom, 18Wake Forest Univ., Winston Salem, NC, 19Univ. of Washington, Washington, WA, 20Balıkesir Univ., Balıkesir, Turkey, 21Univ. of Tennessee, Memphis, TN

610 EFFECT PHOTOBIOMODULATION IN ADDITION WITH A BALANCE PROTOCOL IN FUNCTIONALITY PATIENTS WITH ADVANCED KNEE OSTEOARTHRITIS

A. C. Sardim, Sr., F. C. Tanji, G. Pedrao, L. S. Arrebola, C. E. Pinfildi; Federal Univ. of Sao Paulo - UNIFESP, Santos, Brazil

611 INDIVIDUALIZED TREATMENT AND IMPROVED OUTCOME PREDICTION IN PATIENTS WITH OSTEOARTHRITIS THROUGH MACHINE LEARNING H. Nero1, E. Rehn2, L. E. Dahlberg1; 1Lund Univ., Lund, Sweden, 2Flow NeuroSci., Malmö, Sweden

612 EFFECT OF UNLOADING TRACTION IN PATIENTS WITH KNEE OSTEOARTHRITIS M. T. KHAN; RAJSHAHI Med. Coll. Hosp.,RAJSHAHI, RAJSHAHI, Bangladesh

613 A COMPARATIVE STUDY OF THE EFFECTS OF LATERAL WEDGE INSOLE SHOE MODIFICATION ON THE PATIENTS WITH KNEE OSTEOARTHRITIS M. T. KHAN; RAJSHAHI Med. Coll. Hosp.,RAJSHAHI, RAJSHAHI, Bangladesh

614 CARTILAGE MARKER PLOTS FOR MONITORING OF OSTEOARTHRITIS PATIENTS. A PILOT STUDY M. Winklmayr1,2, J. Landrichinger2,3, M. Riedl4, S. Edtinger5, B. Hölzl6, M. Ritter3,2, M. Gaisberger2,1; 1Dept. for Radon Therapy Res., Ludwig Boltzmann Cluster for

Arthritis and Rehabilitation, Salzburg, Austria, 2Gastein Res. Inst., Paracelsus Med. Univ., Salzburg, Austria, 3Inst. of Physiology and Pathophysiology, Paracelsus Med. Univ., Salzburg, Austria, 4Dept. of Orthopedics and Traumatology, Paracelsus Med. Univ., Salzburg, Austria, 5Baerenhof Hlth.Care & Rehabilitation Ctr., Bad Gastein, Austria, 6Dept. of Internal Med., Landesklinik St. Veit im Pongau, SALK, Paracelsus Med. Univ., Salzburg, Austria

615 REDUCTION IN INFRAPATELLAR FAT PAD (IPFP) VOLUME DURING DIET AND EXERCISE INTERVENTION IS ASSOCIATED WITH IMPROVEMENTS IN KNEE FUNCTION, QUALITY OF LIFE, AND INFLAMMATORY SERUM MARKERS

F. Eckstein1,2, D. Beavers3, W. Wirth1,2, R. F. Loeser4, B. J. Nicklas5, S. L. Mihalko6, G. D. Miller6, D. J. Hunter7, S. P. Messier6; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics GmbH, Ainring, Germany, 3Dept. of Biostatistical Sci., Wake Forest Sch. of Med., Winston-Salem, NC, 4Div. of Rheumatology and the Thurston Arthritis Res. Ctr., Univ. of North Carolina, Sch. of Med., Chapel Hill, NC, 5Section on Gerontology and Geriatric Med., Wake Forest Sch. of Med., Winston-Salem, NC, 6Departement of Hlth.and Exercise Sci., Wake Forest Sch. of Med., Winston-Salem, NC, 7Rheumatology Dept., Inst. of Bone and Joint Res., Univ. of Sydney, Sydney, Australia

616 LOW-DOSE RADIATION THERAPY AS TREATMENT FOR HAND AND KNEE OSTEOARTHRITIS: TWO DOUBLE-BLINDED RCT’S M. J. Minten1, E. A. Mahler1, M. M. Leseman-Hoogenboom2, S. S. Boks1, J. W. Bijlsma3, M. Kloppenburg4, J. W. Leer2, P. M. Poortmans5, F. H. van den Hoogen1,2,

A. A. den Broeder1,2, C. H. van den Ende1,2; 1Sint Maartenskliniek, Nijmegen, Netherlands, 2Radboud Univ. Med. Ctr., Nijmegen, Netherlands, 3Univ. Med. Ctr., Utrecht, Netherlands, 4Univ. Med. Ctr., Leiden, Netherlands, 5Inst. Curie, Paris, France

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617 POSTOPERATIVE EFFECTS OF PROGRESSIVE RESISTANCE TRAINING PRIOR TO TOTAL HIP ARTHROPLASTY - ONE YEAR OUTCOME OF A RANDOMIZED CONTROLLED TRIAL

A. Holsgaard-Larsen1, A. Hermann2, B. Zerahn3, S. Mejdahl4, S. Overgaard1; 1Dept. of Clinical Res., Univ. of Southern Denmark, Odense, Denmark, 2Dept. of Clinical Res., Univ. of Southern Denmark, Odense, Dept. of Orthopedic Surgery, Herlev Univ. Hosp., Herlev, Denmark, 3Dept. of Clinical Physiology and Nuclear Med., Herlev Univ. Hosp., Herlev, Denmark, 4Dept. of Orthopedic Surgery, Herlev Univ. Hosp., Herlev, Denmark

618 VITAMIN D SUPPLEMENTATION AND INFLAMMATORY AND METABOLIC BIOMARKERS IN PATIENTS WITH KNEE OSTEOARTHRITIS: POST-HOC ANALYSES OF A RANDOMIZED CONTROLLED TRIAL D SUPPLEMENTATION AND INFLAMMATORY AND METABOLIC BIOMARKERS IN PATIENTS WITH KNEE OSTEOARTHRITIS: POST-HOC ANALYSES OF A RANDOMIZED CONTROLLED TRIAL

S. Zheng1, B. Wang2, W. Han1, Z. Zhu1, X. Wang1, X. Jin1, B. Antony1, F. Cicuttini2, T. Winzenberg1,3, D. Aitken1, L. Blizzard1, G. Jones1, C. Ding1; 1Menzies Inst. for Med. Res., Univ. of Tasmania, Hobart, Australia, 2Dept. of Epidemiology and Preventive Med., Monash Univ., Melbourne, Australia, 3Faculty of Hlth., Univ. of Tasmania, Hobart, Australia

619 EVALUATION OF THE BEHAVIOURAL PROCESS AND SECONDARY OUTCOMES OF THE SELF-MANAGEMENT OF OSTEOARTHRITIS AND LOW BACK PAIN THROUGH ACTIVITY AND SKILLS CLUSTER RANDOMISED CONTROLLED FEASIBILITY TRIAL

D. A. Hurley, I. Jeffares, R. Segurado, J. Matthews; Univ. Coll. Dublin, Dublin, Ireland

620 ADHERENCE TO IN-HOME GAIT RETRAINING USING FEEDBACK FROM A SMARTPHONE APP M. Wimmer, J. He, C. Ferrigno, N. Shakoor; Rush Univ., Chicago, IL

621 EFFECTS OF SUPERVISED EXERCISE IN OLDER POPULATION HAVING OSTEOARTHRITIS OF KNEE: A RANDOMISED CONTROL TRIAL M. ISLAM; Natl. Inst. OF TRAUMATOLOGY AND ORTHOPAEDIC REHABILITATION, DHAKA, Bangladesh

622 CLINICAL EFFECT OF ACUPUNCTURE AT HUATUO JIAJI POINTS COMBINED WITH TRADITIONAL CHINESE MEDICINE IN TREATMENT OF LUMBAR DEGENERATIVE OSTEOARTHRITIS

T. zhu1, Y. Guo1, M. Li1, F. Zhu2, X. Chai1, H. Zhang1; 1Shaanxi Univ. of Chinese Med., Xianyang City,Shaanxi Province, China, 2Affiliated Hosp. of Shaanxi Univ. of traditional Chinese Med., Xianyang City,Shaanxi Province, China

623 PRELIMINARY FINDINGS OF A NOVEL PHYSICAL THERAPIST ADMINISTERED PHYSICAL ACTIVITY INTERVENTION AFTER TOTAL KNEE REPLACEMENT

M. B. Christiansen, L. M. Thoma, H. Master, D. Mathews, L. A. Schmitt, D. K. White; Univ. of Delaware Dept.s of Physical Therapy and Biomechanics and Movement Sci., Newark, DE

624 IDENTIFYING SUBGROUPS OF PATIENTS WITH DIFFERENTIAL BENEFIT FROM PHYSICAL THERAPY OR INTERNET-BASED EXERCISE TRAINING FOR KNEE OSTEOARTHRITIS

K. D. Allen1,2, L. Arbeeva1, T. Schwartz1, L. Callahan1, Y. Golightly1, A. Goode1, K. Huffman3, C. Coffman3,2; 1Univ. of North Carolina, Chapel Hill, NC, 2Dept. of VA Med. Ctr., Durham, NC, 3Duke Univ. Med. Ctr., Durham, NC

REHABILITATION625 A QUALITATIVE STUDY EXPLORING HOW PHYSICAL THERAPISTS APPROACH MANAGEMENT OF CLIENTS WITH PERCEIVED EARLY KNEE

OSTEOARTHRITIS C. MacKay1, G. Hawker2, S. Jaglal1,3; 1Toronto Rehabilitation Inst., Toronto, ON, Canada, 2Dept. of Med., Univ. of Toronto, Toronto, ON, Canada, 3Dept. of

Physical Therapy, Univ. of Toronto, Toronto, ON, Canada

626 ASSOCIATIONS OF NUMBER OF PHYSICAL THERAPY VISITS AND FREQUENCY OF USE OF AN INTERNET-BASED EXERCISE TRAINING PROGRAM WITH KNEE OSTEOARTHRITIS OUTCOMES

K. D. Allen1,2, M. Pignato3, L. Arbeeva1, T. Schwartz1, L. Callahan1, J. Cooke1, A. Goode4, Y. Golightly1, B. Heiderscheit5, C. Hill1, K. Huffman4,2, H. Seversen6; 1Univ. of North Carolina, Chapel Hill, NC, 2Dept. of VA Med. Ctr., Durham, NC, 3Univ. of North Dakota, Grand Forks, ND, 4Duke Univ. Med. Ctr., Durham, NC, 5Univ. of Wisconsin-Madison, Madison, WI, 6Oregon Reserach Inst., Eugene, OR

627 AN EVALUATION OF TRAK PHYSIOTHERAPY SELF MANAGEMENT INTERVENTION DEVELOPMENT AND DELIVERY FOR KNEE CONDITIONS K. Button1, K. Nicholas2, M. Busse1, M. Collins1, I. Spasic1; 1Cardiff Univ., Cardiff, United Kingdom, 2Cardiff and Vale Univ. Hlth.Board, Cardiff, United Kingdom

628 COMPARATIVE EFFICACY OF ECCENTRIC AND CONCENTRIC-FOCUSED RESISTANCE EXERCISE ON PAIN, LEG STRENGTH AND WALKING ENDURANCE IN KNEE OSTEOARTHRITIS

H. K. Vincent, T. Vasilopoulos, K. R. Vincent; Univ. of Florida, Gainesville, FL

70 | FINAL PROGRAM

629 HIF-1α IN ARTICULAR CARTILAGE IS UP-REGULATED BY TREADMILL RUNNING IN VIVO Y. Fujii1, H. Inoue1, Y. Arai2, S. Nakagawa2, S. Tsuchida1, S. Ichimaru1, S. Shimomura1, O. Mazda3, T. Kubo1; 1Dept. of Orthopaedics, Graduate Sch. of Med. Sci.,

Kyoto Prefectural Univ. of Med., Kyoto, Japan, 2Dept. of Sports and Para-Sports Med., Graduate Sch. of Med. Sci., Kyoto Prefectural Univ. of Med., Kyoto, Japan, 3Dept. of Immunology, Graduate Sch. of Med. Sci., Kyoto Prefectural Univ. of Med., Kyoto, Japan

630 DECREASE IN SELF-REPORTED PAIN AND DYNAMIC KNEE INSTABILITY MEDIATES THE ASSOCIATION BETWEEN WEARING A SOFT KNEE BRACE AND REDUCTION IN ACTIVITY LIMITATIONS IN PERSONS WITH KNEE OSTEOARTHRITIS.

T. Cudejko1, M. van der Esch2, J. Rijnhart3, J. van den Noort1,4, M. van der Leeden1,2, L. D. Roorda2, W. Lems5,6, J. Harlaar1,7, J. Dekker1; 1VU Univ. Med. Ctr. Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rehabilitation Res. Ctr., Reade, Amsterdam, Netherlands, 3Dept. of Epidemiology and Biostatistics, VU Univ. Med. Ctr., Amsterdam, Netherlands, 4Dept. of Radiology and Nuclear Med., Musculoskeletal Imaging Quantification Ctr. (MIQC), Academic Med. Ctr., Amsterdam, Netherlands, 5Jan van Breemen Res. Inst., Reade, Amsterdam, Netherlands, 6Amsterdam Rheumatology & immunology Ctr., Amsterdam Med. Ctr., Reade, VU Univ. Med. Ctr., Amsterdam, Netherlands, 7Delft Univ. of Technology, Delft, Netherlands

631 RELIABILITY ASSESSMENT OF A PATELLOFEMORAL ARTHROMETER USING A FEEDBACK DEVICE WITH SHEET-TYPE PRESSURE SENSORS H. Ohko; Seijoh Univ., aiti, Japan

632 THE ACUTE EFFECTS OF WALKING AN 18-HOLE GOLF COURSE VERSUS USING A MOTORIZED GOLF CART IN SUBJECTS WITH KNEE OSTEOARTHRITIS

P. Jayabalan1, R. Bergman2; 1Shirley Ryan AbilityLab/Northwestern Univ., Chicago, IL, 2Shirley Ryan AbilityLab, Chicago, IL

633 HOW DOES FREQUENCY OF MANUAL THERAPY INFLUENCE OUTCOME FOR PEOPLE WITH KNEE OSTEOARTHRITIS? A FEASIBILITY STUDY. C. M. Chapple, J. H. Abbott, S. Tumilty; Univ. of Otago, Dunedin, New Zealand

634 SHORT AND LONGER TERM EFFECTS OF A TOE IN GAIT RETRAINING PROGRAM IN PEOPLE WITH MEDIAL KNEE OSTEOARTHRITIS R. Richards1, J. C. van den Noort1,2, M. van der Esch3, M. J. Booij1, J. Harlaar1,4; 1VU Univ. Med. center, Dept. of Rehabilitation Med., Amsterdam Movement Sci.,

Amsterdam, Netherlands, 2Academic Med. Ctr., Musculoskeletal Imaging Quantification Ctr. (MIQC),Dept. of Radiology and Nuclear Med., Amsterdam Movement Sci., Amsterdam, Netherlands, 3Reade Ctr. for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 4Delft Univ. of Technology, Delft, Netherlands

635 DETERMINANTS OF QUALITY-OF-LIFE 12-MONTHS FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION IN ACTIVE YOUTH AND YOUNG ADULTS

C. Y. Le1,2, C. Hui1,2, J. L. Whittaker1,2; 1Univ. of Alberta, Edmonton, AB, Canada, 2Glen Sather Sports Med. Clinic, Edmonton, AB, Canada

636 ALTERED LUMBO-PELVIC CONTROL IN PATIENTS WITH LONGSTANDING HIP AND GROIN PAIN COMPARED TO HEALTHY CONTROLS A. Pålsson1, I. Kostogiannis2, E. Ageberg1; 1Dept. of Hlth.Sci., Lund Univ., Lund, Sweden, 2Dept. of Orthopedics, Skåne Univ. Hosp., Malmö, Sweden

637 CARDIORESPIRATORY RESPONSE ACCORDING TO BODY WEIGHT SUPPORT AND GAIT VELOCITY VIA ANTI-GRAVITY TREADMILL AFTER BILATERAL TOTAL KNEE ARTHROPLASTY

B. Kim; Jeju Natl. Univ. Hosp., Jeju, Korea, Republic of

638 THRESHOLD PAIN AFTER PHOTOBIOMODULATION ASSOCIATED TO NEUROMUSCULAR TRAINING IN PATIENTS WITH GRADE 4 KNEE OSTEOARTHRITIS

C. E. Pinfildi, Sr., A. C. Sardim, Sr., F. C. Tanji, G. Pedrao, L. S. Arrebola; Federal Univ. of Sao Paulo - UNIFESP, Santos, Brazil

639 ORTHOPEDIC AND MEDICAL CHARACTERISTICS OF GAIT WITH THE DRAW-IN MANEUVER IN HEALTHY COMMUNITY-DWELLING OLDER ADULTS R. Fujita, S. Ota; Seijoh Univ., Tokai, Japan

640 THE BENEFICIAL EFFECT OF MAITLAND’S MANUAL THERAPY ON MUSCLE MECHANIC AND KNEE FUNCTION DURING THE TREATMENT OF KNEE OSTEOARTHRITIS

M. Pozsgay1, N. Nusser1, T. Atlasz2, M. Váczi2; 1Hosp., Rehabilitation Ctr., Harkány, Hungary, 2Univ. of Pécs, Inst. of Sport Sci. and Physical Ed., Pécs, Hungary

641 USING HOME SENSING TECHNOLOGY TO ASSESS OUTCOME AND RECOVERY AFTER JOINT REPLACEMENT - FINDINGS FROM THE HIP AND KNEE STUDY OF A SENSOR PLATFORM OF HEALTHCARE IN A RESIDENTIAL ENVIRONMENT

S. Grant, M. R. Whitehouse, A. W. Blom, A. Judge, I. Craddock, R. Gooberman-Hill; Univ. of Bristol, Bristol, United Kingdom

642 CHONDROPROTECTIVE AND ANTI-OXIDANT ACTIVITY OF SPERMIDINE IN HUMAN CHONDROCYTES Y. Silvestri1, S. D’adamo1, S. Cetrullo1, M. Minguzzi1, S. Guidotti1, G. Filardo2, E. Mariani2, R. Borzì2, F. Flamigni1; 1Univ. of Bologna, Bologna, Italy, 2Rizzoli

Orthopaedic Inst., Bologna, Italy

71 | FINAL PROGRAM

NUTRACEUTICALS/ DIETARY SUPPLEMENTS AND OA643 PREVENTIVE EFFECT OF A PREBIOTIC FIBRE SUPPLEMENT ON THE DEVELOPMENT OF OSTEOARTHRITIS J. Rios1,2, R. A. Reimer1, D. A. Hart1, R. A. Seerattan1, W. Herzog1; 1Univ. of Calgary, Calgary, AB, Canada, 2CAPES Fndn., Brasíllia, DF, Brazil

644 APIGENIN DERIVATIVES-RICH CLINACANTHUS NUTANS EXTRACT MITIGATES ARTICULAR CARTILAGE DETERIORATION IN OVARIECTOMIZED RATS WITH MONOSODIUM IODOACETATE INDUCED OSTEOARTHRITIS

N. Binti Che Ahmad Tantowi, S. Lau, P. Hussin, S. Mohamed; Universiti Putra Malaysia, UPM Serdang, Malaysia

645 ROSA CANINA FRUIT (ROSEHIP) FOR OSTEOARTHRITIS: A COCHRANE REVIEW X-Y. Hu1, N. Corp2, J. Quicke2, L. Lai1, C. Blondel3, B. Stuart1, A. Abdelmotelb1, G. Leweth1, C. Mallen2, M. Moore1; 1Southampton Univ., Southampton, United

Kingdom, 2Keele Univ., Staffordshire, United Kingdom, 3Paris Inst. of Technology for Life, Paris, France

646 EXPRESSION OF 13 SELENOPROTEIN GENES IN OSTEOARTHRITIS PATIENTS BY MICROARRAY - EVIDENCE FROM A META-ANALYSIS R. Zhang1, A. Yang2,3, J. Zhang2, W. Kang1, J. Li1, P. Yuan1, B. Dong1, C. Shi1, Y. Xiong4; 1Shaanxi Univ. of Chinese Med., Xianyang, China, 2Sch. of Publ. Hlth., Brown

Univ., Providence, 02906, RI, 3Lanzhou Univ., Lanzhou, China, 4Inst. of Endemic Diseases, Sch. of Publ. Hlth., Xi’an Jiaotong Univ. Hlth.Sci. Ctr., Key Lab. of Trace Elements and Endemic Diseases, Natl. Hlth.and Family Planning Commission, Xi’an, China

647 VERNONIA AMYGDALINA PROTECT JOINTS BY SUPPRESSING CHONDROCYTE DIFFERENTIATION IN OSTEOARTHRITIS RAT MODEL I. N. Madzuki, L. S. Fong, S. Mohamed; Universiti putra malaysia, Serdang, Malaysia

648 OSTEOARTHRITIS-RELATED WALKING DISABILITY AND CARDIOVASCULAR DISEASE RISK K-L. H. Joseph, K. Hagen, A. Tveter, S. A. Provan, H. S. Dagfinrud; Diakonhjemmet Hosp., Oslo, Norway

PAIN AND DISABILITY – CLINICAL649 BASED ON META-ANALYSIS, PLACEBO RESPONSES ARE LESS INFLATED FOR OBJECTIVE COMPARED TO SUBJECTIVE MEASURES IN

OSTEOARTHRITIS TRIALS Z. Huang1,2, J. Chen3, J. Ma1, F. Pei1, V. Kraus2; 1West China Hosp., West China Med. Sch., SiChuan Univ., ChengDu, China, 2Duke Molecular Physiology Inst. and

Dept. of Med., Duke Univ. Sch. of Med., Durham, NC, 3West China Sch. of Stomatology, SiChuan Univ., ChengDu, China

650 BRAIN STRUCTURAL AND FUNCTIONAL CHANGES THAT ACCOMPANY PLACEBO AND DULOXETINE ANALGESIA T. J. Schnitzer1, P. Tetreault1, M. N. Baliki2, A. T. Baria1, W. R. Bauer3, A. Apkarian1; 1Northwestern Univ. Feinberg Sch. of Med., Chicago, IL, 2Shirley Ryan

AbililtyLab, Chicago, IL, 3Univ. of Toledo, Toledo, OH

651 THE 10-YEAR COURSE OF THE CLINICAL AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) CRITERIA FOR HIP AND KNEE OSTEOARTHRITIS IN AN EARLY SYMPTOMATIC COHORT, DATA FROM CHECK.

D. Schiphof1, J. Runhaar1, E. J. Waarsing1, E. W. van Spil2, M. van Middelkoop1, S. M. Bierma-Zeinstra1; 1Erasmus MC, Rotterdam, Netherlands, 2UMC Utrecht, Utrecht, Netherlands

652 VALIDATION OF THE INTERMITTENT AND CONSTANT OSTEOARTHRITIS PAIN QUESTIONNAIRE IN HAND OSTEOARTHRITIS M. Gløersen1, P. Steen Pettersen1, T. Kvien1,2, I. Haugen1; 1Diakonhjemmet Hosp., Oslo, Norway, 2Univ. of Oslo, The Med. Faculty, Inst. for Clinical Med., Oslo,

Norway, Oslo, Norway

653 INCREMENTAL PROGNOSTIC PERFORMANCE OF A NEW VISUAL TRAJECTORIES QUESTIONNAIRE FOR PAIN: PROSPECTIVE COHORT OF KNEE PAIN IN PRIMARY CARE

K. Pihl1, M. J. Thomas2,3, E. Parry2, G. Peat2, P. Campbell2,4, K. Dunn2; 1Univ. of Southern Denmark, Odense, Denmark, 2Arthritis Res. UK Primary Care Ctr., Res. Inst. for Primary Care & Hlth.Sci., Keele Univ., Keele, United Kingdom, 3Haywood Academic Rheumatology Ctr., Staffordshire and Stoke-on-Trent Partnership NHS Trust, Burslem, United Kingdom, 4South Staffordshire and Shropshire Fndn. Trust, St George’s Hosp., Stafford, United Kingdom

654 10-YEAR TRAJECTORIES OF PAIN IN EARLY KNEE AND HIP OSTEOARTHRITIS; THE CHECK STUDY J. Runhaar1, E. Waarsing1, D. Schiphof1, M. van Middelkoop1, E. van Spil2, S. Bierma-Zeinstra1; 1Erasmus MC Univ. Med. Ctr. Rotterdam, Rotterdam, Netherlands,

2Univ. Med. Ctr. Utrecht, Utrecht, Netherlands

655 THE ASSOCIATION BETWEEN PHYSICAL ACTIVITY AND PSYCHOLOGICAL CHARACTERISTICS IN PEOPLE WITH KNEE OSTEOARTHRITIS D. Uritani1,2, R. S. Hinman2, J. Kasza3, P. K. Campbell2, T. Egerton2, B. Metcalf2, K. L. Bennell2; 1Kio Univ., Nara, Japan, 2The Univ. of Melbourne, Victoria,

Australia, 3Monash Univ., Victoria, Australia

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656 COMPARATIVE RESPONSIVENESS OF GENERIC HEALTH OUTCOME MEASURES AT 3 AND 12 MONTHS FOLLOWING 8 WEEKS OF SUPERVISED PATIENT EDUCATION AND EXERCISE THERAPY. A STUDY OF 2 904 PATIENTS WITH OSTEOARTHRITIS FROM THE DANISH GLAD® REGISTRY

E. M. Roos1, D. T. Grønne1, S. T. Skou1,2, J. E. Ware, Jr.3, B. Gandek3; 1Univ. of Southern Denmark, Odense M, Denmark, 2Dept. of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Denmark, 3Univ. of Massachusetts Med. Sch., Worcester, MA

657 DETERMINANTS OF TRAJECTORIES OF MULTI-SITE PAIN IN KNEE OSTEOARTHRITIS F. Pan1, J. Tian1, T. Winzenberg1, F. Cicuttini2, G. Jones1; 1Univ. of Tasmania, Hobart, Australia, 2Monash Univ. Med. Sch., Melbourne, Australia

658 GRC 27864, NOVEL, MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 ENZYME INHIBITOR: PHASE 1 STUDY TO EVALUATE SAFETY, PK AND BIOMARKERS IN HEALTHY, ADULT SUBJECTS

S. SANT, M. TANDON, V. Menon, G. Gudi, V. Kattige, N. Khairatkar Joshi, K. Korukonda, O. Levine-Dolberg; Glenmark Pharmaceuticals Ltd, Mumbai, India

659 COMPARING OBSERVED WITH EXPECTED ASSESSMENTS OF OSTEOARTHRITIC PAIN OVER TIME: APPLICATION OF SUCCESSIVE PREDICTION TO DATA FROM THE OSTEOARTHRITIS INITIATIVE

S. Mongin, N. Onizuka, L. Langsetmo, A. Shmagel; UMN, Minneapolis, MN

660 DISABILITY IN UNDERWEIGHT PERSONS WITH OR AT HIGHER RISK FOR KNEE OSTEOARTHRITIS N. Ghosh, J. S. Chmiel, O. Almagor, K. W. Hayes, K. C. Moisio, A. H. Chang, J. Szymaszek, L. Sharma; Northwestern Univ., Chicago, IL

661 THE RELATIONSHIP BETWEEN PRESSURE PAIN THRESHOLDS AND ANXIETY IN PATELLOFEMORAL OSTEOARTHRITIS: EXPLORATORY DATA H. Urban (Umapathy)1,2, J. P. Eyles1,2, D. J. Hunter1,2, K. Mills3; 1Univ. of Sydney, Sydney, Australia, 2Inst. of Bone and Joint Res., The Kolling Inst., Univ. of Sydney,

and Rheumatology Dept., Royal North Shore Hosp., Sydney, Australia, 3Faculty of Med. and Hlth.Sci., Macquarie Univ., Sydney, Australia

662 SERUM HYALURONAN LEVELS ARE ASSOCIATED WITH DISABILITY FOR ACTIVITY OF DAILY LIVING IN PATIENTS WITH KNEE OSTEOARTHRITIS REGARDLESS OF THE RADIOGRAPHIC SEVERITY OF THE DISEASE

Y. Shimura1,2, H. Kurosawa1, H. Kaneko3, H. Nojiri1, Y. Iwase1, K. Kaneko3, M. Ishijima3; 1Juntendo Tokyo Koto Geriatric Med. Ctr., Koto, Tokyo, Japan, 2Minamikoshigaya Hosp., Koshigaya, Saitama, Japan, 3Juntendo Univ., Bunkyo, Tokyo, Japan

663 DAILY PAIN MEASUREMENTS AND RETROSPECTIVE PAIN MEASUREMENTS IN HIP OSTEOARTHRTITIS PATIENTS WITH INTERMITTENT PAIN C. Teirlinck, D. Sonneveld, S. Bierma-Zeinstra, P. Luijsterburg; Erasmus MC, Rotterdam, Netherlands

664 VACCINATION AGAINST NERVE GROWTH FACTOR IS AN EFFECTIVE PAIN TREATMENT IN MURINE OSTEOARTHRITIS I. S. von Loga, A. El-Turabi, J. Zarebska, M. F. Bachmann, T. Vincent; Univ. of Oxford, Oxford, United Kingdom

PAIN – MOLECULAR MECHANISMS665 EVALUATING THE HORIZONTAL LADDER ASSAY IN A MURINE MODEL OF OSTEOARTHRITIS K. Schroeder1, C. Marques1, K. Beaghen1, R. J. Miller2, A-M. Malfait1, R. E. Miller1; 1Rush Univ. Med. Ctr., Chicago, IL, 2Northwestern Univ., Chicago, IL

666 NON-INVASIVE MURINE JOINT LOADING MODEL: A NOVEL MODEL FOR OSTEOARTHRITIC PAIN F. ter Heegde1, A. P. Luiz2, S. Santana-Varela2, J. N. Wood2, C. Chenu1; 1Royal Vet. Coll., Comparative BioMed. Sci., Skeletal Biology Group, Londen, United

Kingdom, 2Univ. Coll. London, Wolfson Inst. for BioMed. Res., Molecular Nociception Group, Londen, United Kingdom

667 INHIBITORS OF PHLPP PHOSPHATASES ARE HIGHLY STABLE AND SUPPRESS PAIN FOLLOWING JOINT INJURY E. W. Bradley1, E. L. Taylor1, C. Castillejo Becerra1,2, I. M. Lorang1, S. A. Burhow1, J. M. Reid1, J. J. Westendorf1; 1Mayo Clinic, Rochester, MN, 2The Ohio State

Univ., Columbus, OH

668 PERIPHERAL SENSITIZATION AND NEUROPATHIC PAIN IN THE RAT MEDIAL MENISCAL TEAR MODEL OF POST-TRAUMATIC OSTEOARTHRITIS M. S. O’Brien1, C. DeBow2, J. J. McDougall2; 1Melissa O’Brien, Halifax, NS, Canada, 2Dalhousie Univ., Halifax, NS, Canada

669 MODULATION OF THE NGF - TRKA PATHWAY FOR TREATMENT OF JOINT PAIN: PRECLINICAL IN VIVO EVALUATION IN MICE K. Ängeby Möller1, P. Forsell2, G. Nordvall2, J. Sandin2, C. I. Svensson1; 1Karolinska Inst.t, Stockholm, Sweden, 2AlzeCure Fndn., Huddinge, Sweden

670 SEX-SPECIFIC DIFFERENCES IN PAIN AND NERVE INJURY IN THE LYSOPHOSPHATIDIC ACID MODEL OF RAT NEUROPATHIC OSTEOARTHRITIS A. Reid1, C. DeBow2, J. J. McDougall2; 1Allison Reid, Halifax, NS, Canada, 2Dalhousie Univ., Halifax, NS, Canada

671 GENETICALLY LABELED REPORTER MICE ENABLE DETAILED STUDY OF THE SENSORY INNERVATION OF THE MURINE KNEE JOINT A. M. Obeidat1, R. J. Miller2, D. M. Menichella2, P. B. Tran1, D. Ren2, N. D. Jayaraj2, R. E. Miller1, A. Malfait1; 1Rush Univ. Med. center, chicago, IL, 2Northwestern

Univ. Feinberg Sch. of Med., chicago, IL

73 | FINAL PROGRAM

672 BILATERAL NEUROIMMUNE CHANGES IN A UNILATERAL MURINE MODEL OF OSTEOARTHRITIS P. B. Tran1, R. E. Miller1, S. Ishihara1, R. J. Miller2, A-M. Malfait1; 1Dept. of Internal Med., Div. of Rheumatology, Rush Univ. Med. Ctr., Chicago, IL, 2Dept. of

Pharmacology, Northwestern Univ., Chicago, IL

673 LEG PAIN BEHAVIOR CORRELATES FIBROSIS AND ANGIOGENESIS OF THE INFRAPATELLAR FAT PAD INDUCED BY MONOIODOACETIC ACID H. Onuma, K. Tsuji, T. Hoshino, I. Sekiya, T. Muneta, H. Koga; Tokyo Med. and Dental Univ., Tokyo, Japan

674 DEVELOPMENT AND CHARACTERIZATION OF THE MONOSODIUM IODOACETATE-INDUCED OSTEOARTHRITIS MODEL IN CANINES: PHARMACOLOGICAL REVERSAL OF PAIN SYMPTOMS AND HISTOPATHOLOGICAL FINDINGS

J. D. Pomonis1, A. M. Bendele2, T. Van Valkenburg1, L. Gulstad1, J. Vislisel1, M. E. Smith1; 1American Preclinical Services, Minneapolis, MN, 2Bolder BioPATH, Boulder, CO

675 EVALUATION OF CARTILAGE DEGENERATION AND OSTEOARTHRITIS PAIN ON FEMALE AND MALE MOUSE MODEL OF OSTEOARTHRITIS I. Park, J-I. Hong, H. Hwang, H. Kim; Div of Rhematology, Hallym Univeristy Sacred Heart Hosp., Anyang, Korea, Republic of

676 CONDITIONED MEDIUM FROM CHONDROCYTES AND SYNOVIOCYTES DERIVED FROM OA PATIENTS MODULATES EXCITABILITY OF NEUROBLASTOMA CELLS (NERVE CELLS)

B. Steinecker1, W. Kullich2, A. Mann3, H. G. Kress3, L. Weigl3; 1Ludwig Boltzmann Cluster of Arthritis and Rehabilitation, Dept. for Rehabilitation, Groebming, Austria, 2Ludwig Boltzmann Cluster of Arthritis and Rehabilitation, Dept. for Rehabilitation, Saalfelden, Austria, 3Dept. of Special Anaesthesia and Pain Therapy, Med. Univ. Vienna, Vienna, Austria

677 ANALGESIC EFFECTS OF MORPHINE AT REST AND DURING MOVEMENT ON KNEE OSTEOARTHRITIS INDUCED BY INTRA-ARTICULAR MONOSODIUM IODOACETATE IN YOUNG RATS

J. Morko, J. Vaaraniemi, J. Lehtimaki, J. Zdrojewska, Z. Peng, J. M. Halleen; Pharmatest Services Ltd, Turku, Finland

678 REGION-SPECIFIC KNEE CARTILAGE DEGRADATION ASSOCIATES WITH ALTERED KINEMATICS IN EXERCISE AND IMMOBILIZED OSTEOARTHRITIS RATS

E. S. Cooper1,2, L-C. Tsai3, K. M. Hetzendorfer1, Y-H. Chang1, N. J. Willett2; 1Georgia Tech, Atlanta, GA, 2Emory Univ., Atlanta, GA, 3Georgia State Univ., Atlanta, GA

BIOMECHANICS & GAIT679 DECLINING WALKING SPEED ASSOCIATES WITH INCREASED BONE MARROW LESION VOLUME AND EFFUSION VOLUME IN

INDIVIDUALS WITH ACCELERATED KNEE OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE M. S. Harkey1, J. E. Davis1, B. Lu2, M. Zhang1, L. Price1, C. B. Eaton3, M. F. Barbe4, G. H. Lo5, T. E. McAlindon1, J. B. Driban1; 1Tufts Med. Ctr., Boston, MA,

2Brigham & Women’s Hosp. and Harvard Med. Sch., Boston, MA, 3Alpert Med. Sch. of Brown Univ., Pawtucket, RI, 4Temple Univ. Sch. of Med., Philadelphia, PA, 5Baylor Coll. of Med., Houston, TX

680 THE IMMEDIATE EFFECT OF A SOFT KNEE BRACE ON DYNAMIC KNEE INSTABILITY DURING PERTURBED WALKING IN PERSONS WITH KNEE OSTEOARTHRITIS.

T. Cudejko1, M. van der Esch2, J. Schrijvers1, R. Richards1, J. van den Noort1,3, T. Wrigley4, M. van der Leeden1,2, L. D. Roorda2, W. Lems5,6, J. Harlaar1,7, J. Dekker1; 1VU Univ. Med. Ctr. Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rehabilitation Res. Ctr., Reade, Amsterdam, Netherlands, 3Dept. of Radiology and Nuclear Med., Musculoskeletal Imaging Quantification Ctr. (MIQC), Academic Med. Ctr., Amsterdam, Netherlands, 4Ctr. for Hlth., Exercise and Sports Med., Dept. of Physiotherapy, Univ. of Melbourne, Melbourne, Australia, 5Jan van Breemen Res. Inst., Reade, Amsterdam, Netherlands, 6Amsterdam Rheumatology & immunology Ctr., Amsterdam Med. Ctr., Reade, VU Univ. Med. Ctr., Amsterdam, Netherlands, 7Delft Univ. of Technology, Delft, Netherlands

681 ACTIVE FEEDBACK GAIT RETRAINING ALTERS FOOT PRESSURE PATTERNS AND REDUCES KNEE ADDUCTION MOMENT IN AN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTED POPULATION

J. C. Erhart-Hledik1, G. B. Mahtani1,2, J. L. Asay1,2, C. R. Chu1,2, T. P. Andriacchi1,2; 1Stanford Univ., Stanford, CA, 2VA Palo Alto, Palo Alto, CA

682 LOWER PROTEOGLYCAN DENSITY WITHIN THE TALAR ARTICULAR CARTILAGE IS ASSOCIATED WITH WORSE POSTURAL CONTROL IN INDIVIDUALS WITH CHRONIC ANKLE INSTABILITY

K. Song, B. Pietrosimone, E. Wikstrom; UNC Chapel Hill, Chapel Hill, NC

683 RELATIONSHIP BETWEEN GAIT COMPLEXITY, PHYSICAL FUNCTION AND KNEE PAIN—DATA FROM THE MOST STUDY N. A. Segal*1, K. G. Rabe*1, J. M. Hausdorff2, E. Gazit2, I. Tolstykh3, D. T. Felson4, C. E. Lewis5, M. C. Nevitt3; 1Univ. of Kansas Med. Ctr., Kansas City, KS, 2Tel

Aviv Sourasky Med. Ctr., Tel Aviv, Israel, 3Univ. of California-San Francisco, San Francisco, CA, 4Boston Univ., Boston, MA, 5Univ. of Alabama-Birmingham, Birmingham, AL

74 | FINAL PROGRAM

684 KNEE 3D KINEMATICS DIFFER IN A LARGE COHORT OF KNEE OSTEOARTHRTIS PATIENTS BASED ON THEIR RADIOGRAPHIC SEVERITY A. CAGNIN1,2, M. CHOINIÈRE2,3, N. J BUREAU2,3, M. DURAND2,3, A. FUENTES4, L. DE POLO1,2, N. HAGEMEISTER1,2; 1École de Technologie Supérieure

(ÉTS), Laboratoire d›Imagerie et d›Orthopédie (LIO), Montréal, QC, Canada, 2Ctr. de Recherche du CHUM (CRCHUM), Montréal, QC, Canada, 3Université de Montréal (UdeM), Montréal, QC, Canada, 4Emovi Inc., Montréal, QC, Canada

685 MALE AND FEMALE GAIT COMPENSATIONS IN A MOUSE MODEL OF MEDIAL MENISCUS DESTABILIZATION E. H. Lakes, S. H. Haus, Y. C. Pacheco, K. D. Allen; Univ. of Florida, Gainesville, FL

686 THE IMPACT OF SELF-REPORTED KNEE JOINT INSTABILITY ON WALKING MECHANICS IN INDIVIDUALS WITH MODERATE KNEE OSTEOARTHRITIS M. Baker, N. Urquhart, W. Stanish, D. Rutherford; Dalhousie Univ., Halifax, NS, Canada

687 A 3D UPRIGHT MRI STUDY OF PATELLAR ALIGNMENT IN PARTICIPANTS WITH PATELLOFEMORAL OSTEOARTHRITIS AND MATCHED CONTROLS E. M. Macri1, A. G. d’Entremont1, K. M. Crossley2, H. F. Hart2, B. B. Forster1, D. R. Wilson1, C. R. Ratzlaff3, C. H. Goldsmith4, K. M. Khan1; 1Univ. of British

Columbia, Vancouver, BC, Canada, 2La Trobe Univ., Melbourne, Australia, 3Univ. of Arizona, Tucson, AZ, 4Simon Fraser Univ., Burnaby, BC, Canada

688 DIFFERENCES IN USING A SINGLE WEEK OF ACCELEROMETER DATA VERSUS AVERAGING MULTIPLE WEEKS IN INDIVIDUALS WITH KNEE OSTEOARTHRITIS AND ASYMPTOMATIC CONTROLS: IMPLICATIONS FOR CUMULATIVE LOAD CALCULATIONS

K. E. Costello, J. L. Astephen Wilson, C. L. Hubley-Kozey; Dalhousie Univ., Halifax, NS, Canada

689 HIP JOINT LOADING DURING WALKING IN PEOPLE WITH HIP OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS L. E. Diamond1, K. Allison2,3, F. Dobson3, M. Hall2; 1Menzies Hlth.Inst. Queensland, Sch. of Allied Hlth.Sci., Griffith Univ., Gold Coast, Australia, 2Ctr. for Hlth.,

Exercise and Sports Med., Dept. of Physiotherapy, Univ. of Melbourne, Melbourne, Australia, 3Dept. of Physiotherapy, Sch. of Hlth.Sci., The Univ. of Melbourne, Melbourne, Australia

690 EFFECT OF KNEE UNLOADING SHOES ON REGIONAL PLANTAR PRESSURES IN PEOPLE WITH SYMPTOMATIC KNEE OSTEOARTHRITIS. J. A. van Tunen1, K. L. Paterson2, T. V. Wrigley2, B. R. Metcalf2, J. B. Thorlund1, R. S. Hinman2; 1Univ. of Southern Denmark, Odense, Denmark, 2The Univ. of

Melbourne, Melbourne, Australia

691 LOSS OF PROTEOGLYCAN CONTENT PRIMES ARTICULAR CARTILAGE FOR MECHANICALLY INDUCED DAMAGE M. E. Cooke, B. M. Lawless, S. W. Jones, L. M. Grover; Univ. of Birmingham, Birmingham, United Kingdom

692 INTER-LABORATORY COMPARISON OF GAIT WAVEFORMS IN INDIVIDUALS WITH KNEE OSTEOARTHRITIS J. Schrijvers1, D. Rutherford2, R. Richards1, J. van den Noort1,3, M. van der Esch4, J. Harlaar1,5; 1VU Med. Ctr., Dept. of Rehabilitation Med., Amsterdam

Movement Sci., Amsterdam, Netherlands, 2Sch. of Physiotherapy, Sch. of BioMed. Engineering, Dalhousie Univ.,, Halifax, NS, Canada, 3Musculoskeletal Imaging Quantification Ctr. (MIQC), Academic Med. Ctr., Dept. of Radiology and Nuclear Med., Amsterdam, Netherlands, 4Amsterdam Rehabilitation Res. Ctr., Reade, Amsterdam, Netherlands, 5Delft Univ. of Technology, Dept. of Biomechanical Engineering, Delft, Netherlands

693 QUADRICEPS WEAKNESS IS ASSOCIATED WITH LESSER PROTEOGLYCAN DENSITY IN THE MEDIAL FEMORAL CARTILAGE SIX-MONTHS FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION

B. Pietrosimone1, S. Pfeiffer1, M. Harkey2, K. Wallace1, C. Hunt1, T. Blackburn1, D. Lalush1, D. Nissman1, J. Spang1; 1Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, 2Tufts Med. Ctr., Boston, MA

694 EXERCISE EFFECTS ON GAIT IN A RODENT MODEL OF OSTEOARTHRITIS B. Y. Jacobs, K. D. Allen; Univ. of Florida, Gainesville, FL

695 EFFECT OF A LATERAL WEDGE INSOLE AND SIMPLE KNEE SLEEVE AS A SINGLE AND COMBINED TREATMENT ON BIOMECHANICAL AND CLINICAL OUTCOMES IN INDIVIDUALS WITH KNEE OSTEOARTHRITIS (THE IN-SLEEVE STUDY)

O. W. Althomali, R. K. Jones, A. Liu; salford Univ., Manchester, United Kingdom

696 ELEVATED CONTACT STRESS AFTER ACETABULAR FRACTURE CORRELATES WITH DEVELOPMENT OF RADIOGRAPHIC OA H. D. Thomas, K. N. Dibbern, T. C. Holland, J. L. Marsh, M. C. Willey, J. E. Goetz, D. D. Anderson; The Univ. of Iowa, Iowa City, IA

697 INTRA-OP BIOMECHANICAL GUIDANCE IMPROVES ARTICULAR FRACTURE REDUCTION, LIMITING POST-TRAUMATIC OA RISK A. M. Kern, M. C. Willey, J. L. Marsh, D. D. Anderson; The Univ. of Iowa, Iowa City, IA

698 RELIABILITY AND VALIDITY OF KNEE JOINT ANGLES AND MOMENTS IN PATIENTS WITH KNEE OSTEOARTHRITIS USING A TREADMILL-BASED MOVEMENT ANALYSIS SYSTEM

R. F. Pinto1,2, T. B. Birmingham1,2, I. C. Jones2, R. F. Moyer1,3, K. M. Leitch1,2, J. R. Giffin1,2; 1Bone and Joint Inst., Western Univ., London, ON, Canada, 2Wolf Orthopaedic Biomechanics Lab., Fowler Kennedy Sport Med. Clinic, London, ON, Canada, 3Sch. of Physical Therapy, Dalhousie Univ., Halifax, NS, Canada

699 PRESSURE-BASED AUDITORY FEEDBACK TO REDUCE KNEE MOMENTS IN SUBJECTS WITH MEDIAL KNEE OSTEOARTHRITIS J. He, C. Ferrigno, N. Shakoor, M. Wimmer; Rush Univ. Med. Ctr., Chicago, IL

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700 THE EFFECT OF KNEE JOINT EFFUSION ON GAIT MECHANICS AND MUSCLE ACTIVATIONS IN INDIVIDUALS WITH MODERATE KNEE OSTEOARTHRITIS

S. Saleh, C. Hubley-Kozey, W. Stanish, C. Gillis, D. Rutherford; Dalhousie Univ., Halifax, NS, Canada

701 LOWER LIMB MUSCLE ACTIVATION PATTERNS DURING FOOT ROTATION GAIT MODIFICATION IN PEOPLE WITH KNEE OSTEOARTHRITIS J. M. Charlton1, G. L. Hatfield2, J. A. Guenette1, M. A. Hunt1; 1Univ. of British Columbia, Vancouver, BC, Canada, 2Univ. of the Fraser Valley, Chilliwack, BC, Canada

702 GAIT SPEED IS ASSOCIATED WITH MEDIAL MENISCUS EXTRUSION IN PATIENTS FROM EARLY- TO END-STAGE KNEE OSTEOARTHRITIS H. Arita1, H. Kaneko1, M. Ishijima1,2, M. Ishibashi2, S. Hada1,3, L. Liu1,4, Y. Negishi1, M. Momoeda1, T. Aoki4, Y. Takazawa1, H. Ikeda1, K. Kaneko1,4; 1Juntendo Univ.,

Tokyo, Japan, 2Ctr. Of Innovation (COI) program, Tokyo, Japan, 3Tokyo Rosai Hosp., Tokyo, Japan, 4Sportology Ctr., Tokyo, Japan

703 RELATIONSHIP AMONG BIOMECHANICAL RISK FACTORS ASSOCIATED WITH RADIOGRAPHIC PROGRESSION OF HIP OSTEOARTHRITIS H. Tateuchi1, H. Akiyama2, K. Goto1, K. So3, Y. Kuroda1, N. Ichihashi1; 1Kyoto Univ., Kyoto, Japan, 2Gifu Univ., Gifu, Japan, 3Osaka Red Cross Hosp., Osaka, Japan

704 TIBIOFEMORAL JOINT SPACE NARROWING: CAN DYNAMIC JOINT STIFFNESS 2 YEARS AFTER ANTERIOR CRUCIATE LIGAMENT INJURY YEARS PREDICT NARROWING 5 YEARS AFTER INJURY?

J. L. Johnson, L. M. Thoma, L. Snyder-Mackler; Univ. of Delaware, Newark, DE

705 DISTINGUISHING BETWEEN KNEE REHABILITATION EXERCISES USING INERTIAL MEASUREMENT UNITS P. Jones1, S. Woodgate2,3, D. Williams2, P. Biggs2, K. Nicholas4, K. Button5,4, P. Corcoran6, C. Holt2; 1Sch. of Engineering, Cardiff Univ., CARDIFF, United

Kingdom, 2Sch. of Engineering, Cardiff Univ., Cardiff, United Kingdom, 3Sch. of Med., Cardiff Univ., Cardiff, United Kingdom, 4Physiotherapy Dept., Cardiff & Vale Univ. Hlth.Board, Cardiff, United Kingdom, 5Sch. of Hlth.care Sci., Cardiff Univ., Cardiff, United Kingdom, 6Sch. of Computer Sci. and Informatics, Cardiff Univ., Cardiff, United Kingdom

706 ALTERED MUSCLE SYNERGIES DURING GAIT IN INDIVIDUALS WITH KNEE OSTEOARTHRITIS E. M. Casto, K. A. Boyer; Univ. of Massachusetts Amherst, Amherst, MA

707 DIFFERENCES IN THE COORDINATION OF GAIT BASED ON BODY MASS INDEX IN SEDENTARY YOUNG ADULTS J. Freedman Silvernail, S. Bradley, K. Wiegand; Univ. of Nevada, Las Vegas, Las Vegas, NV

708 SMART KNEEBRACE FOR OSTEOARTHRITIS PATIENTS’ GAIT ANALYSIS: CORRELATIONS OF MOTION CAPTURE AND PHYSICAL FUNCTION PARAMETERS, PAIN, SELF-REPORTED QUESTIONNAIRES

Z. Zhou1, J. Lin1, H. Ma2, B. Jiang2, Z. Li1; 1Peking Univ. People’s Hosp., Beijing, China, 2Beijing Noitom Technology Ltd., Beijing, China

709 MEASURING GAIT KINEMATICS AND SELF SELECTED WALKING SPEED IN HEALTHY ADULTS USING INERTIAL MEASUREMENT UNITS D. Hodgins; European technology for Business Holdings Ltd, Codicote, United Kingdom

710 ABSTRACT FOR OARSI T. Shimizu1, A. R. Markes1, M. A. Samaan1, K. Mamoto1,2, R. B. Souza1, X. Li1,2, C. Ma1; 1Univ. of California, San Francisco, San Francisco, CA, 2Cleveland Clinic,

Cleveland, OH

711 ACUTE INFLUENCES OF DRAW-IN MANEUVER FOR KNEE ADDUCTION MOMENT AND HIP AND TRUNK MUSCLE ACTIVITIES DURING A PERSON’S MANNER OF WALKING

S. Ota1, H. Ohko1, R. Fujita1, Y. Ogawa2, H. Ota2; 1Seijoh Univ., Tokai, Japan, 2Nagoya Tokusyukai Gen. Hosp., Kasugai, Japan

712 INFLUENCE OF HAMSTRING ACTIVITY ON KNEE MOMENTS DURING LOADING RESPONSE OF GAIT IN INDIVIDUALS FOLLOWING ACL RECONSTRUCTION

P. E. Lin, N. H. Neamat Allah, C. Chan, G. J. Bogie, L. P. Gately, S. M. Sigward; Univ. of Southern California, Los Angeles, CA

713 A GAIT ANALYSIS USING WEARABLE DEVICES ON ACTIVITIES OF DAILY LIFE IN PATIENTS WITH KNEE OSTEOARTHRITIS Y. Iwama1, K. Harato1, A. Sakurai1, K. Nishizawa1, Y. Morishige1, K. Kaneda1, Y. Niki1, S. Kobayashi1, N. Ogihara2, M. Matsumoto1, M. Nakamura1, T. Nagura3; 1Dept.

of Orthopedic Surgery, Keio Univ. Sch. of Med., Tokyo, Japan, 2Dept. of Mechanical Engineering, Keio Univ., Yokohama, Japan, 3Dept. of Clinical Biomechanics, Keio Univ. Sch. of Med., Tokyo, Japan

714 DO NON-RESPONDERS TO LATERAL WEDGE INSOLES REMAIN NON-RESPONDERS AFTER AN EIGHT WEEK INTERVENTION? A. Liu1, D. T. Felson2,3, S. C. Carter3,4, M. J. Callaghan5,4, M. J. Parkes3,4, R. K. Jones1,4; 1Univ. of Salford, Salford, United Kingdom, 2Boston Univ., Boston, MA,

3The Univ. of Manchester, Manchester, United Kingdom, 4Manchester Academic Hlth.Sci. Ctr., Manchester, United Kingdom, 5Manchester Metropolitan Univ., Manchester, United Kingdom

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715 GAIT CHARACTERISTICS BASED ON PAIN DETECT QUESTIONNAIRE AND PAIN CATASTROPHIZING SCALE IN PATIENTS WITH KNEE OSTEOARTHRITIS

K. Kaneda1, K. Harato1, A. Sakurai1, K. Nishizawa1, Y. Morishige1, Y. Iwama1, Y. Niki1, S. Kobayashi1, M. Matsumoto1, M. Nakamura1, T. Nagura2; 1Dept. of Orthopedic Surgery, Keio Univ. Sch. of Med., Tokyo, Japan, 2Dept. of Clinical Biomechanics, Keio Univ. Sch. of Med., Tokyo, Japan

716 SPECIFIC CONTRIBUTION OF HIP ABDUCTOR MUSCLE STRENGTH TO TURNING MOVEMENT IN INDIVIDUALS WITH KNEE OSTEOARTHRITIS H. Iijima1,2, A. Yorozu3, Y. Suzuki4, R. Eguchi5, T. Aoyama4, M. Takahashi1; 1Dept. of System Design Engineering, Keio Univ., Yokohama, Japan, 2Japan Society for

the Promotion of Sci., Tokyo, Japan, 3Graduate Sch. of Sci. and Technology, Keio Univ., Yokohama, Japan, 4Dept. of Physical Therapy, Human Hlth.Sci., Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan, 5Sch. of Sci. for Open and Environmental Systems, Graduate Sch. of Sci. and Technology, Keio Univ., Yokohama, Japan

717 HOW DOES FRONTAL PLANE ALIGNMENT OF A TOTAL KNEE REPLACEMENT INFLUENCE BIOMECHANICAL FUNCTION AND LOADING? D. E. Williams1, A. Metcalfe2, P. Jones1, J. Madete1, G. Whatling1, P. Kempshall3, K. Lyons3, M. Forster3, C. Holt1; 1Cardiff Univ., Cardiff, United Kingdom, 2The

Univ. of Warwick, Coventry, United Kingdom, 3Univ. Hosp. of Wales, Cardiff, United Kingdom

718 ISOKINETIC KNEE EXTENSION ASSESSMENT ASSOCIATION WITH GAIT LOADING RESPONSE AND WALKING SPEED F. B. Dias de Oliveira, M. R. Souza, R. R. Campedelli, D. S. Specialli, R. Fonseca, E. Antoniolli, M. Ferretti; Hosp. Israelita Albert Einstein, São Paulo, Brazil

719 GAIT KINEMATICS CHANGES IN POST TRAUMATIC KNEE OSTEOARTHRITIS WITH DESTABILIZED MEDIAL MENISCUS IN RAT A. Nakahata1, H. iijima1,2, M. Tanima-Nagai3, A. Ito1, J. Tajino1, W. Kyan1, J. Zang1, X. Ji1, T. Wang1, T. Aoyama1, K. Nishitani1, H. Kuroki1; 1Kyoto Univ., kyoto, Japan,

2Keio Univ., Yokohama, Japan, 3NIH, Bethesda, MD

720 ACUTE QMRI RESPONSE OF TIBIOFEMORAL ARTICULAR CARTILAGE IN PARTICIPANTS AT RISK FOR KNEE OA AFTER CHALLENGED WALKING H. F. Atkinson1,2, T. B. Birmingham1,2, R. F. Moyer3, J. S. Milner1, J. D. Thiessen1, R. T. Thompson1, D. W. Holdsworth1,2, J. R. Giffin1,2; 1Univ. of Western Ontario,

London, ON, Canada, 2Western Bone & Joint Inst., London, ON, Canada, 3Dalhousie Univ., Halifax, NS, Canada

721 DYNAMIC LIMIT OF STABILITY AND ANKLE JOINT FUNCTION FOLLOWING NEUROMUSCULAR TRAINING OF UNSTABLE ANKLE JOINTS A. R. Ibrahim, A. A. Abdallah; Faculty of Physical Therapy, Giza, Egypt

722 HOW DO LOWER LIMB JOINT MOMENTS AND MUSCLE ACTIVATIONS CHANGE WHEN FORWARD TRUNK LEAN INCREASES? W. A. Alghamdi1,2, S. J. Preece1, R. Jones1, H. Tucker3; 1Univ. of Salford, Manchester, United Kingdom, 2Al Baha Univ., Al-Baha, Saudi Arabia, 3Univ. of Bath,

Bath, United Kingdom

723 PATELLAR POSITION EFFECTS ON KNEE LOADING DURING TAICHI EXERCISE M. Zhang, B. Cheng, J. Pang, H. Zhan; Shuguang Hosp. Affiliated to Shanghai Univ. of Traditional Chinese Med., Shanghai, China

724 KNEE EXTENSION POWER IS RELIABLE FOR GROUP ANALYSIS BUT LESS SENSITIVE TO INDIVIDUAL CHANGE A. A. Gatti, N. M. Brisson, P. W. Stratford, M. R. Maly; McMaster, Hamilton, ON, Canada

725 BONE MINERAL DENSITY AT FEMORAL NECK REFLECT WEIGHT BEARING CONDITION IN PATIENTS WITH KNEE OSTEOARTHRITIS K. Nishizawa1, K. Harato1, Y. Morishige1, A. Sakurai1, S. Kobayashi1, Y. Niki1, M. Matsumoto1, M. Nakamura1, T. Nagura2; 1Dept. of Orthopedic Surgery, Keio Univ.

Sch. of Med., Shinjuku-ku, Japan, 2Dept. of Clinical Biomechanics, Keio Univ. Sch. of Med., Shinjuku-ku, Japan

726 THE EFFECT OF QUADRICEPS STRENGTH ON GAIT KINEMATICS IN ONSET AND PROGRESS OF KNEE OSTEOARTHRITIS K. Nishino1, G. Omori2, Y. Koga3, M. Tanaka1, T. Mochizuki4, H. Koga4, A. Nawata5,4, D. Kogawa6; 1Niigata Inst. for Hlth.and Sports Med., Niigata, Japan, 2Niigata

Univ. of Hlth.and Welfare, Niigata, Japan, 3Ninoji Onsen Clinic, Niigata, Japan, 4Niigata Univ. Graduate Sch. of Med. and Dental Sci., Niigata, Japan, 5Alcare Co., ltd., Tokyo, Japan, 6Mizuno Co., ltd., Osaka, Japan

727 OVER-GROUND WALKING VALIDATION OF A SMART SHOE FOR ESTIMATING FOOT PROGRESSION ANGLE J. M. Charlton1, H. Xia2, M. A. Hunt1, P. B. Shull2; 1Univ. of British Columbia, Vancouver, BC, Canada, 2Shanghai Jiao Tong Univ., Shanghai, China

728 ACCELERATION PATTERNS OF THE TRUNK DURING WALKING IN INDIVIDUALS WITH VARUS THRUST: TOWARD AN ESTABILISHMENT OF THE PATHOMECHANICS OF VARUS THRUST

H. Iijima1,2, R. Eguchi3, T. Aoyama4, M. Takahashi1; 1Dept. of System Design Engineering, Keio Univ., Yokohama, Japan, 2Japan Society for the Promotion of Sci., Tokyo, Japan, 3Sch. of Sci. for Open and Environmental Systems, Graduate Sch. of Sci. and Technology, Keio Univ., Yokohama, Japan, 4Dept. of Physical Therapy, Human Hlth.Sci., Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan

729 THE RELATION OF CUMULATIVE LOAD TO WORSENING KNEE CARTILAGE DAMAGE OVER TWO YEARS: THE MOST STUDY D. Mathews1, D. K. White1, T. Neogi2, A. Guermazi2, F. Roemer2, L. M. Thoma1, H. Master1, M. B. Christiansen1, C. E. Lewis3, M. C. Nevitt4, J. C. Torner5, J. J.

Stefanik1; 1Univ. of Delaware, Newark, DE, 2Boston Univ. Sch. of Med., Boston, MA, 3Univ. of Alabama, Birmingham, AL, 4Univ. of California San Francisco, San Francisco, CA, 5Univ. of Iowa, Iowa City, IA

77 | FINAL PROGRAM

730 DECREASED SYNOVIAL FLUID PROTEOGLYCAN-4 CONCENTRATION IN ACL-TRANSECTED KNEE JOINTS IS DUE TO A DYNAMIC IMBALANCE IN BIOSYNTHESIS, CLEARANCE, AND EFFUSION

A. R. Raleigh, M. J. Cravotta, J. J. Garcia, B. L. Schumacher, K. Kato, G. S. Firestein, K. Masuda, R. L. Sah; Univ. of California, San Diego, La Jolla, CA

731 DEVELOPMENT OF NOVEL LUBRICATION VECTORS TO REDUCE SURFACE FRICTION AND INHIBIT PATHOLOGICAL CHONDROCYTE GENE REGULATION IN VIVO

W. Lin1, R. Mashiach1, Z. Liu1, Y. Cao1, R. Goldberg1, A. Angayarkanni1, L. Zhu2, J. Zarebska2, A. Chanalaris2, T. Vincent2, J. Klein1; 1Weizmann Inst. of Sci., Rehovot, Israel, 2Oxford Univ., Oxford, United Kingdom

MECHANOBIOLOGY732 ASSESSMENT ON THE EFFECTS OF HIGH AND LOW IN VIVO CYCLIC COMPRESSIVE LOADING ON THE PROGRESSION OF CARTILAGE

DEGENERATION IN RAT KNEE JOINT J. XIANG1, A. Nakahata1, A. Ito1, H. Iijima2,1, J. Tajino1, M. Tanima-Nagai3, W. Kiyan1, J. Zhang1, T. Wang1, K. Nishitani4, T. Aoyama1, H. Kuroki1; 1Dept. of Physical

Therapy, Human Hlth.Sci., Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan, 2Dept. of System Design Engineering, Keio Univ., Yokohama, Japan, 3Med. Genetics Branch, Natl. Human Genome Res. Inst., NIH, Bethesda, MD, 4Dept. of Orthopaedic Surgery, Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan

733 TIBIAL CARTILAGE VOLUME OF THE BACK LEG VERSUS THE HIGHER LOADED FRONT LEG IN ELITE MALE AND FEMALE ENGLISH CRICKET FAST BOWLERS

M. E. Jones1,2, T. Wedatilake3, A. Warren3, R. Young1, R. W. Kerslake4, N. Peirce3, K. M. Leyland1,2, N. Arden1,2, J. L. Newton1,2; 1Univ. of Oxford, Oxford, United Kingdom, 2Arthritis Res. UK Ctr. for Sport, Exercise, and Osteoarthritis, Oxford, United Kingdom, 3England and Wales Cricket Board, Loughborough, United Kingdom, 4Nottingham Univ. Hosp. NHS Trust, Nottingham, United Kingdom

734 THE RELATIONSHIP BETWEEN TREADMILL RUNNING AND HIF-2α ON RAT KNEE ARTICULAR CARTILAGE S. Shimomura1, H. Inoue1, Y. Arai2, S. Nakagawa2, S. Tsuchida1, S. Ichimaru1, Y. Fujii1, O. Mazda3, T. Kubo1; 1Dept. of Orthopaedics, Kyoto Prefectural Univ. of

Med., Kyoto, Japan, 2Dept. of Sports and Para-Sports Med., Kyoto Prefectural Univ. of Med., Kyoto, Japan, 3Dept. of immunology, Kyoto Prefectural Univ. of Med., Kyoto, Japan

735 THE LIMITED KNEE RANGE OF MOTION CAUSES PROGRESSION OF CARTILAGE DEGENERATION IN THE OSTEOARTHRITIC KNEE JOINT: AN EXPERIMENTAL STUDY USING A PRECLINICAL MODEL OF OSTEOARTHRITIS

H. Iijima1,2, M. Tanima-Nagai3, K. Uchiyama4, A. Ito5, J. Tajino5, A. Nakahata5, W. Kiyan5, J. Zhang5, X. Ji5, T. Wang5, T. Aoyama5, K. Nishitani6, M. Takahashi1, H. Kuroki5; 1Dept. of System Design Engineering, Keio Univ., Yokohama, Japan, 2Japan Society for the Promotion of Sci., Tokyo, Japan, 3Med. Genetics Branch, Natl. Human Genome Res. Inst., NIH, Bethesda, MD, 4Human Hlth.Sci., Faculty of Med., Kyoto Univ., Kyoto, Japan, 5Dept. of Physical Therapy, Human Hlth.Sci., Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan, 6Dept. of Orthopaedic Surgery, Graduate Sch. of Med., Kyoto Univ., Kyoto, Japan

736 INVESTIGATION OF ARTICULAR CARTILAGE STRUCTURAL AND BIOMECHANICAL PROPERTIES BY ATOMIC-FORCE MICROSCOPY C. Prein, F. Lagugne-Labarthet, F. Beier; Univ. of Western Ontario, London, ON, Canada

737 ADDITION OF EXCESS THYROID HORMONE INDUCES DETRIMENTAL CHANGES IN HUMAN EX VIVO FULL THICKNESS OSTEOCHONDRAL EXPLANTS

E. Houtman, M. van Hoolwerff, A. Rodríguez Ruiz, N. Lakenberg, E. Suchiman, R. Nelissen, Y. Ramos, I. Meulenbelt; LUMC, Leiden, Netherlands

738 MURINE CRUCIATE LIGAMENT PATHOLOGY DURING OSTEOARTHRITIS DEVELOPMENT L. Ramos1, G. Bou-Gharios1, A. Pitsillides2, A. Elsheikh3, E. Comerford1, B. Poulet1; 1Inst. of Ageing and Chronic Disease, Univ. of Liverpool, Liverpool, United

Kingdom, 2Royal Vet. Coll., Univ. of London, London, United Kingdom, 3Sch. of Engineering, Univ. of Liverpool, Liverpool, United Kingdom

739 EFFECT OF FRIZZLED RELATED PROTEIN (FRZB) ON MUSCLES: AN INVERSE RELATIONSHIP BETWEEN FRZB AND CALPAIN-3 WITH POTENTIAL IMPACT ON MUSCLE DYSTROPHY AND OSTEOARTHRITIS

L. Casas-Fraile1,2, F. M. Cornelis3, D. Costamagna4,5, A. Rico1, M. Sampaolesi4,5, A. López de Munain1,2, A. Sáenz1,2, R. J. Lories3,6; 1Biodonostia Hlth. research Inst., Donostia, Spain, 2Ctr. for Networked BioMed. Res. on Neurodegenerative Diseases (CIBERNED), Carlos III Hlth.Inst., Spanish Ministry of Economy and Competitiveness, Madrid, Spain, 3Lab. of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Res. Ctr., Dept. of Dev. and Regeneration, KU Leuven, Leuven, Belgium, 4Translational Cardiomyology Translational Cardiomyology Lab., Stem Cell Biology and Embryology Unit, Dept. of Dev. and Regeneration, KU Leuven, Leuven, Belgium, 5Human Anatomy Unit, Dept. of Publ. Hlth., Experimental and Forensic Med., Univ. of Pavia, Pavia, Italy, 6Div. of Rheumatology, Univ. Hosp. Leuven, Leuven, Belgium

78 | FINAL PROGRAM

MENISCUS, MUSCLE, TENDON & LIGAMENT BIOLOGY740 CHANGE IN PATIENT-REPORTED OUTCOMES IN PATIENTS WITH AND WITHOUT MECHANICAL SYMPTOMS UNDERGOING

ARTHROSCOPIC MENISCAL SURGERY: A PROSPECTIVE COHORT STUDY K. Pihl1, A. Turkiewicz2, M. Englund2,3, L. S. Lohmander4, U. Jørgensen5, N. Nissen6, J. Schjerning7, J. B. Thorlund1; 1Dept. of Sports Sci. and Clinical Biomechanics,

Univ. of Southern Denmark, Odense, Denmark, 2Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopedics, Clinical Epidemiology Unit, Lund, Sweden, 3Clinical Epidemiology Res. and Training Unit, Boston Univ. Sch. of Med., Boston, MA, 4Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopedics, Lund, Sweden, 5Dept. of Orthopedics and Traumatology, Odense Univ. Hosp., Odense, Denmark, 6Dept. of Orthopedics, Lillebaelt Hosp., Kolding, Denmark, 7Dept. of Orthopedics, Lillebaelt Hosp., Vejle, Denmark

741 DEVELOPMENT AND INTERNAL VALIDATION OF A PROGNOSTIC MODEL TO PREDICT CHANGE IN PATIENT-REPORTED OUTCOMES 1 YEAR FOLLOWING ARTHROSCOPIC MENISCAL SURGERY

K. Pihl1, J. Ensor2, G. Peat2, M. Englund3,4, L. S. Lohmander5, U. Jørgensen6, N. Nissen7, J. V. Fristed8, J. B. Thorlund1; 1Dept. of Sports Sci. and Clinical Biomechanics, Univ. of Southern Denmark, Odense, Denmark, 2Ctr. for Prognosis Res., Res. Inst. for Primary Care & Hlth.Sci., Keele Univ., Keele, Staffordshire, United Kingdom, 3Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopedics, Clinical Epidemiology Unit, Lund, Sweden, 4Clinical Epidemiology Res. and Training Unit, Boston Univ. Sch. of Med., Boston, MA, 5Lund Univ., Faculty of Med., Dept. of Clinical Sci. Lund, Orthopedics, Lund, Sweden, 6Dept. of Orthopedics and Traumatology, Odense Univ. Hosp., Odense, Denmark, 7Dept. of Orthopedics, Lillebaelt Hosp., Kolding, Denmark, 8Dept. of Orthopedics, Lillebaelt Hosp., Vejle, Denmark

742 ACUTE INFLAMMATORY RESPONSE IS PREREQUISITE TO INITIATE PROPER HEALING PROCESS DURING MENISCAL REGENERATION IN MICE. M. Ojima1, K. Hiyama1, H. Katagiri2, K. Miyatake1, T. Muneta1, I. Sekiya3, H. Koga1, K. Tsuji2; 1Joint Surgery and Sports Med., Tokyo Med. and Dental Univ., Tokyo,

Japan, 2Dept. of Cartilage Regeneration, Tokyo Med. and Dental Univ., Tokyo, Japan, 3Ctr. for Stem Cell and Regenerative Med., Tokyo Med. and Dental Univ., Tokyo, Japan

743 PRE- AND POST-NATAL DEVELOPMENT OF THE TENDON INTER-FASCICULAR MATRIX AND FASCICLES IN THE EQUINE SUPERFICIAL DIGITAL FLEXOR TENDON AND COMMON DIGITAL EXTENSOR TENDON

D. E. Zamboulis1, C. T. Thorpe2, H. L. Birch3, H. R. Screen4, P. D. Clegg1; 1Univ. of Liverpool, Liverpool, United Kingdom, 2Royal Vet. Coll., London, United Kingdom, 3Univ. Coll. London, Stanmore, United Kingdom, 4Queen Mary Univ. of London, London, United Kingdom

744 MECHANISMS OF ACTION OF CHONDROITIN SULFATE AND GLUCOSAMINE IN MUSCLE TISSUE: IN VITRO AND IN VIVORESULTS. A NEW POTENTIAL TREATMENT FOR MUSCLE INJURIES?

E. Montell, Sr.1, P. Contreras-Muñoz, Sr.2, A. Torrent, Sr.1, M. de la Varga, Sr.3, G. Rodas, Sr.4, M. Marotta, Sr.2; 1Pre-Clinical R&D Area, PharmaSci. Div., Bioibérica, Barcelona, Spain, 2Leitat Fndn., Leitat Technological Ctr. and Bioengineering Cell Therapy and Surgery in Congenital Malformations Lab., Vall D´Hebron Inst., Barcelona, Spain, 3Leitat Fndn., Leitat Technological Ctr., Barcelona, Spain, 4Leitat Fndn., Leitat Technological Ctr. and FC Barcelona Med. Services, Barcelona, Spain

745 A HISTOLOGICAL STUDY OF THE MEDIAL MENISCUS POSTERIOR ROOT TIBIAL INSERTION T. Hino, T. Furumatsu, S. Miyazawa, M. Fujii, Y. Kodama, Y. Kamatsuki, Y. Okazaki, T. Ozaki; Okayama Univ., okayama, Japan

746 CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS’ M. Barrow1, S. Tew1, E. Comerford1, M. McNicholas2, R. Oldershaw1; 1Univ. of Liverpool, Liverpool, United Kingdom, 2Aintree Univ. Hosp., Liverpool, United Kingdom

747 THIGH MUSCLE AND ADIPOSE TISSUE CHANGES DURING SYMPTOMATIC AND RADIOGRAPHIC KNEE OSTEOARTHRITIS PROGRESSION - DATA FROM THE OSTEOARTHRITIS INITIATIVE

J. Kemnitz1, W. Wirth1,2, F. Eckstein1,2, A. G. Culvenor1,3; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics GmbH, Ainring, Germany, 3La Trobe Univ., Sch. of Allied Hlth., Melbourne, Australia

748 ASSOCIATIONS AMONG QUADRICEPS STRENGTH, JOINT STRUCTURE, AND PAIN AND AMBULATION IN INDIVIDUALS WITH OSTEOARTHRITIS AND SYMPTOMATIC MENISCAL TEAR

B. A. Luc-Harkey1, C. E. Saffron-Norton1, L. A. Mandl2, J. N. Katz1, E. Losina1; 1Brigham and Women’s Hosp., Boston, MA, 2Hosp. for Special Surgery, New York, NY

OA: LIGAMENT/MENISCUS/TENDON/MUSCLE749 MENISCAL DEGENERATION IS CORRELATED WITH STRUCTURAL ARTICULAR CARTILAGE DAMAGE DURING THE COURSE OF

COLLAGENASE-INDUCED OSTEOARTHRITIS L. Utomo, S. M. Eijgenraam, D. E. Meuffels, Y. M. Bastiaansen-Jenniskens, G. J. van Osch; Erasmus MC Univ. Med. Ctr., Rotterdam, Netherlands

750 TEXTURE FEATURES FROM T2 AND T1RHO MAPPING OF MENISCUS IN NORMAL AND OSTEOARTHRITIC KNEE JOINTS H. J. Yu, S. Takao, S. Hagiwara, H. Yoshioka; Univ. of California, Irvine, CA

79 | FINAL PROGRAM

751 DEFINING THE FACTORS THAT ALTER OA RISK FOLLOWING ACL INJURY USING PRE-CLINICAL ANIMAL MODELS. C. Blaker1,2, S. Zaki2, E. Clarke1, C. Little2; 1Murray Maxwell Biomechanics Lab., Inst. of Bone and Joint Res., Kolling Inst., Northern Sydney Local Hlth.District,

Sydney Med. Sch., Univ. of Sydney, St. Leonards, Australia, 2Raymond Purves Bone and Joint Res. Lab., Inst. of Bone and Joint Res., Kolling Inst., Northern Sydney Local Hlth.District, Sydney Med. Sch., Univ. of Sydney, St. Leonards, Australia

752 CHARACTERIZING THE DISTINCT STRUCTURAL CHANGES ASSOCIATED WITH SELF-REPORTED KNEE INJURY AMONG INDIVIDUALS WITH INCIDENT KNEE OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE

J. E. Davis1, M. S. Harkey1, R. J. Ward1, J. W. MacKay2, B. Lu3, L. Price1, C. B. Eaton4, M. F. Barbe5, G. H. Lo6, T. E. McAlindon1, J. B. Driban1; 1Tufts Med. Ctr., Boston, MA, 2Univ. of Cambridge Sch. of Clinical Med., Cambridge, United Kingdom, 3Brigham & Women’s Hosp. and Harvard Med. Sch., Boston, MA, 4Alpert Med. Sch. of Brown Univ., Pawtucket, RI, 5Temple Univ. Sch. of Med., Philadelphia, PA, 6Baylor Coll. of Med., Houston, TX

753 NON-INVASIVE ANTERIOR CRUICIATE RUPTURE DEVICE FOR CLININCALLY RELEVANT IN VIVO RAT MODELS S. Brown, J. Pistiner, B. Sharma; Univ. of Florida, Gainesville, FL

754 ASSOCIATION OF MUCOID DEGENERATION OF THE ANTERIOR CRUCIATE LIGAMENT AT MR IMAGING WITH MEDIAL TIBIOFEMORAL OSTEOARTHRITIS PROGRESSION AT RADIOGRAPHY DATA FROM THE OSTEOARTHRITIS INITIATIVE

R. Kwee1, N. Hafezi-Nejad2, F. Roemer3, B. Zikria1, D. Hunter4, A. Guermazi3, S. Demehri1; 1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, 2Univ. System of Maryland, Baltimore, MD, 3Boston Univ. Sch. of Med., Boston, MA, 4Kolling Inst., Univ. of Sydney, Sydney, Australia

755 CHANGES IN THIGH MUSCLE STRENGTH PRIOR TO AND CONCURRENT WITH INCIDENT KNEE PAIN- DATA FROM THE OSTEOARTHRITIS INITIATIVE

A. S. Ruhdorfer1,2, W. Wirth1, A. Culvenor1,3, F. Eckstein1; 1Paracelsus Med. Univ. Salzburg & Nuremberg, Salzburg, Austria, 2Trauma Dept., Unfallkrankenhaus Salzburg, Salzburg, Austria, 3La Trobe Univ., Sch. of Allied Hlth., Melbourne, Australia

756 PATELLAR TENDON ENTHESIS ABNORMALITIES AND THEIR ASSOCIATION WITH KNEE PAIN AND STRUCTURAL ABNORMALITIES IN OLDER ADULTS.

S. Mattap1, D. Aitken1, K. Wills1, A. Halliday2, C. Ding1, W. Han1, F. Cicuttini3, G. Jones1, L. Laslett1; 1Menzies Inst. for Med. Res., Univ. of Tasmania, Hobart, Australia, 2Royal Hobart Hosp., Hobart, Australia, 3Monash Univ., Melbourne, Australia

757 COMPARISON VERIFICATION BETWEEN TEXTURE ANALYSIS BASED ON T2MAP MRI AND HISTOLOGICAL ANALYSIS OF THE MENISCAL DEGENERATION IN PATIENTS WITH KNEE OSTEOARTHRITIS

T. Aoki1, M. Ishijima1,2, H. Kaneko3, S. Hada3, L. Liu1,3, H. Arita3, M. Kinoshita3, Y. Negishi3, M. Momoeda3, Y. Tamura1,4, H. Watada4,1, R. Kawamori1,4, K. Kaneko1,3; 1Sportology Ctr., Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 2Dept. of Med. for Orthopaedics and Motor Organ, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, Tokyo, Japan, 3Dept. of Med. for Orthopaedics and Motor Organ, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 4Dept. of Metabolism & Endocrinology, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan

758 EDUCATIONAL PROGRAM IN SUBJECTS WITH KNEE OSTEOARTHRITIS IMPROVES ADHERENCE, AEROBIC AND FUNCTIONAL CAPACITY M. U. Rezende1, J. M. Silva2, T. C. Spada2, L. S. Francisco2, H. P. Santos2, J. M. Greve1, E. G. Ciolac2; 1Faculdade Med. USP, Sao Paulo, Brazil, 2São Paulo State

Univ. (UNESP), Sao Paulo, Brazil

759 ASSOCIATION BETWEEN THE HYPERTROPHY AND THE EXTRUSION OF MEDIAL MENISCUS USING 3T MRI IN PATIENTS WITH KNEE OSTEOARTHRITIS

S. Hada1,2, M. Ishijima1,3, H. Kaneko1, L. Lizu1,4, M. Kinoshita1, H. Arita1, T. Aoki4, Y. Takazawa1, H. Ikeda1, Y. Tomita2, K. Kusunose2, Y. Okada3, K. Kaneko1,4; 1Dept. of Med. for Orthopaedics and Motor Organ, Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan, 2Tokyo Rosai Hosp., Tokyo, Japan, 3Dept. of Pathophysiology for Locomotive and Neoplastic Diseases, Juntendo Univ., Tokyo, Japan, 4Sportology Ctr., Juntendo Univ. Graduate Sch. of Med., Tokyo, Japan

760 3D MENISCAL POSITION PREDICTS KNEE REPLACEMENT IN FAST PROGRESSING KNEE OSTEOARTHRITIS M. Roth1, K. Emmanuel1,2, W. Wirth1,3, C. Kwoh4, D. J. Hunter5, M. J. Hannon6, F. Eckstein1,3; 1Inst. of Anatomy, Paracelsus Med. Univ. Salzburg & Nuremberg,

Salzburg, Austria, 2Dept. of Orthopedics and Traumatology, Paracelsus Med. Univ., Salzburg, Austria, 3Chondrometrics GmbH, Ainring, Germany, 4Univ. of Arizona Arthritis Ctr., Tucson, AZ, 5Royal North Shore Hosp. and Inst. of Bone and Joint Res., Univ. of Sydney, Sydney, Australia, 6Div. of Rheumatology and Clinical Immunology, Univ. of Pittsburgh Sch. of Med., Pittsburgh, PA

761 ASSOCIATION OF BASELINE MENISCAL SYMPTOMS ON OUTCOMES OF OPERATIVE AND NON-OPERATIVE TREATMENT OF MENISCAL TEAR IN PATIENTS WITH OSTEOARTHRITIS

L. A. MacFarlane, H. Yang, J. E. Collins, E. Losina, J. N. Katz; Brigham and Women’s Hosp., Boston, MA

762 EFFICACY OF LOW-DOSE AMITRIPTYLINE FOR CHRONIC LOW BACK PAIN: A DOUBLE-BLIND, RANDOMISED CONTROLLED TRIAL D. Urquhart1, A. Wluka1, M. van Tulder2, S. Heritier1, A. Forbes1, C. Fong1, Y. Wang1, M. Sim1, S. Gibson3, C. Arnold1, F. Cicuttini1; 1Monash Univ., Melbourne,

Australia, 2Vrije Univ.it, Amsterdam, Netherlands, 3Natl. Ageing Res. Inst., Melbourne, Australia

80 | FINAL PROGRAM

763 EFFECT OF ZOLEDRONIC ACID AND DENOSUMAB IN PATIENTS WITH LOW BACK PAIN AND MODIC CHANGE: A PROOF OF PRINCIPLE TRIAL G. Cai1, L. Laslett1, D. Aitken1, A. Halliday2, F. Pan1, P. Otahal1, D. Speden3, T. Winzenberg1, G. Jones1; 1Menzies Inst. for Med. Res., Hobart, Australia, 2Dept. of

Radiology, Royal Hobart Hosp., Hobart, Australia, 3Dept. of Rheumatology, Royal Hobart Hosp., Hobart, Australia

SPINE & INTERVERTEBRAL DISC764 THE RELATIONSHIP BETWEEN SPINAL PAIN AND COMORBIDITY IN OLDER AUSTRALIAN WOMEN K. de Luca1, L. Parkinson2, S. Haldeman3, J. Byles4, F. Blyth5; 1Univ. of Sydney, Sydney, Australia, 2Central Queensland Univ., Rockhampton, Australia, 3Dept. of

Neurology, Univ. of California, California, CA, 4Univ. of Newcastle, Newcastle, Australia, 5Concord Clinical Sch., Univ. of Sydney, Sydney, Australia

765 LARGER PARASPINAL MUSCLE CROSS-SECTIONAL AREA IS RELATED TO DISABILITY FROM LOW BACK PAIN, BUT NOT LOW BACK PAIN INTENSITY T. A. Ranger1, F. M. Cicuttini1, T. S. Jensen2, S. Heritier1, D. M. Urquhart1; 1Monash Univ., Melbourne, Australia, 2Univ. of Southern Denmark, Odense, Denmark

766 THE COURSE AND CONTRIBUTORS TO BACK PAIN IN MIDDLE-AGED WOMEN OVER NINE YEARS: DATA FROM THE AUSTRALIAN LONGITUDINAL STUDY OF WOMEN’S HEALTH

S. R. Brady1, S. Hussain1, W. J. Brown2, S. Heritier1, Y. Wang1, H. Teede1, D. M. Urquhart1, F. M. Cicuttini1; 1Monash Univ., Melbourne, Australia, 2Univ. of Queensland, Queensland, Australia

767 THE ASSOCITATION BETWEEN SELF-REPORTED SPINAL MORNING STIFFNESS AND RADIOGRAPHIC LUMBAR DISC DEGENERATION R. van den Berg1, E. M. Jongbloed1, N. O. Kuchuk2, B. W. Koes1, E. H. Oei1, S. M. Bierma-Zeinstra1, P. A. Luijsterburg1; 1Erasmus MC, Rotterdam, Netherlands,

2Tergooi Hosp., Hilversum, Netherlands

768 INTRADISCAL DELIVERY OF CELECOXIB-LOADED MICROSPHERES RESTORES DISC HOMEOSTASIS IN A PRECLINICAL CANINE MODEL OF INTERVERTEBRAL DISC DEGENERATION

A. R. Tellegen1, I. Jansen2, M. Beukers1, A. Miranda-Bedate1, W. De Jong1, N. Woike3, J. C. Thies3, G. Mihov3, B. P. Meij1, L. B. Creemers2, M. A. Tryfonidou1; 1Utrecht Univ., Utrecht, Netherlands, 2Univ. Med. Hosp., Utrecht, Netherlands, 3DSM Res., Geleen, Netherlands

769 IMPAIRED ANNULUS FIBROSUS DEVELOPMENT AND VERTEBRAL FUSION CAUSE SEVERE SCOLIOSIS IN JNK1 FL/FL COL2-CRE /JNK2 DOUBLE KNOCK OUT MICE.

V. Ulici1, K. L. Kelley1, L. Longobardi1, M. A. McNulty2, C. A. Séguin3, R. F. Loeser, Jr.1; 1UNC at Chapel Hill, Chapel Hill, NC, 2Indiana Univ. Sch. of Med., Indianapolis, IN, 3Western Univ., London, ON, Canada

770 HEDGEHOG SIGNALING IS ASSOCIATED WITH INTERVERTEBRAL DISC DEGENERATION AND OSTEOPHYTE FORMATION H. Fukuda, E. Nakamura, K. Sabanai, K. Okuma, M. Tsukamoto, S. Takada, A. Sakai; Univ. of Occupational and Environmental Hlth., Kitakyuusyu, Japan

771 TENOMODULIN LOSS-OF-FUNCTION IS ASSOCIATED WITH INTERVERTEBRAL DISK DEGENERATION D. Lin1, D. Docheva2; 1Ludwig-Maximilians-Univ., Munich, Germany, 2Univ. Regensburg Med. Ctr., Regensburg, Germany

772 CHONDROGENIC DIFFERENTIATION OF BONE MARROW-DERIVED MESENCHYMAL STEM CELLS WITH TGF-BETA, BMP2, GDF5 OR COMBINATIONS THEREOF DOES NOT RESULT IN A NUCLEUS PULPOSUS CELL PHENOTYPE.

G. G. van den Akker, M. P. Bakx, L. M. de Kroon, E. L. Vitters, H. M. van Beuningen, E. N. Blaney Davidson, P. M. van der Kraan; Radboud UMC, Nijmegen, Netherlands

773 ASSOCIATION BETWEEN N-CADHERIN, KERATIN-19 AND LUMICAN WITH DISC SPACE NARROWING: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT

A. Goode1, V. B. Kraus2, Y. Golightly3, J. Huebner4, S. George1, J. Martin2, L. DeFrate2, J. M. Jordan5; 1Duke Univ.; Duke Clinical Res. Inst., Durham, NC, 2Duke Univ. Med. Ctr., Durham, NC, 3Univ. of North Carolina, Thurston Arthritis Ctr., Chapel Hill, NC, 4Duke Univ. Med. Ctr., Molecular Physiology Ctr., Durham, NC, 5Univ. of North Carolina, Thurston Arthritis Ctr., Durham, NC

774 OPTIMIZING A THREE DIMENSIONAL IN VITRO INTERVERTEBRAL DISC ENVIRONMENT FOR THE CO-CULTURE OF HUMAN NUCLEUS PULPOSUS CELLS AND MESENCHYMAL STROMAL CELLS

E. A. Growney Kalaf, F. Barry; Natl. Univ. of Ireland Galway, Galway, Ireland

775 EFFICACY AND SAFETY EVALUATION OF THE HEXADECYLAMIDE DERIVATIVE OF HYALURONAN ON INTERVERTEBRAL DISC DEGENERATION IN A RABBIT ANNULAR PUNCTURE MODEL

A. Schiavinato1, P. Boissier2, P. Mainil-Varlet2; 1Fidia farmaceutici, Abano Terme, Italy, 2Aginko Res., Marly, Switzerland

776 IDENTIFICATION OF DIFFERENTIAL GROWTH DIFFERENTIATION FACTOR 6 SIGNALLING RESPONSES IN SUBPOPULATIONS OF HUMAN BONE MARROW AND ADIPOSE-DERIVED STEM CELLS: IMPLICATIONS FOR INTERVERTEBRAL DISC REGENERATION

T. Hodgkinson, F. Wignall, J. Hoyland, S. M. Richardson; The Univ. of Manchester, Manchester, United Kingdom

81 | FINAL PROGRAM

777 GROWTH DIFFERENTIATION FACTOR 6 PROMOTES A HEALTHY NUCLEUS PULPOSUS CELL PHENOTYPE THROUGH SMAD AND SMAD-INDEPENDENT SIGNALLING PATHWAYS

S. M. Richardson1, T. Hodgkinson1, A. Wei2, B. Shen2, A. Diwan2, J. Hoyland1; 1The Univ. of Manchester, Manchester, United Kingdom, 2Univ. of New South Wales, Sydney, Australia

778 TGF<β> ENHANCES TISSUE FORMATION BY NUCLEUS PULPOUS PASSAGED CELLS IN VITRO S. Ashraf1, K. Chatoor1, J. Chong1, P. Santerre2, R. Kandel1,3; 1Mount Sinai Hosp., Toronto, ON, Canada, 2Inst. of Biomaterials and BioMed. Engineering, Univ. of

Toronto, Toronto, ON, Canada, 3Inst. of Biomaterials and BioMed. Engineering, Univ. of Toronto, ON, Canada, Toronto, ON, Canada

779 DESIGN AND EVALUATION OF ELECTROSPUN STRUCTURED BIOMATERIALS FOR ANNULUS FIBROSUS REPAIR M. D. Gluais1,2, J. Clouet1,3, S-Y. Chew4, J. Guicheux1,5, C. Le Visage1,2; 1Inserm, UMR 1229, RMeS, Regenerative Med. and Skeleton, Université de Nantes,

ONIRIS, F-44042, Nantes, France, 2Université de Nantes, UFR Odontologie, F-44042, Nantes, France, 3CHU Nantes, Pharmacie Centrale, PHU 11, F-44093, Nantes, France, 4Div. of Chemical and Biomolecular Engineering, Sch. of Chemical and BioMed. Engineering, Nanyang Technological Univ., Singapore, Singapore, 5CHU Nantes, PHU4 OTONN, F-44093, Nantes, France

780 AN OPEN LABEL STUDY TO EVALUATE SAFETY AND EFFICACY OF A NOVEL HYDROGEL (HYALODISC) IN PATIENTS WITH DEGENERATIVE DISC DISEASE

E. Mazza1, F. Mondaini2, S. Marcia3, T. Torri4, G. Barbanti Brodano5, N. Giordan6; 1Interventional Radiology, Firenze, Italy, 2Azienda Ospedaliero-Univ.ria Careggi, Firenze, Italy, 3Ospedale SS. Trinità, Cagliari, Italy, 4Ospedale Apuano, Massa, Italy, 5Istituto Ortopedico Rizzoli, Bologna, Italy, 6Fidia Farmaceutici S.p.A., Abano Terme, Italy

781 DEVELOPMENT OF CONTROLLED RELEASE SYSTEMS OF BIOLOGICAL FACTORS FOR THE REGENERATION OF INTERVERTEBRAL DISC L. Frapin, J. Clouet, N. Henry, C. Chedeville, J. Guicheux, C. Le Visage; INSERM U1229 RMeS, Nantes, France

782 ACUPOTOMY THERAPY FOR JOINT PAIN RELIEF OF LUMBAR DISC HERNIATION-SYSTEMATIC REVIEW AND META-ANALYSIS S. Wang; Shaanxi Univ. of Chinese Med., Xianyang, China

783 IS THERE AN ASSOCIATION BETWEEN DIABETES AND NECK AND BACK PAIN? - A SYSTEMATIC REVIEW D. Pozzobon1, M. L. Ferreira2; 1Univ. of Sydney, Sydney, Australia, 2Inst. of Bone and Joint Res., The Kolling Inst., Sydney Med. Sch., Univ. of Sydney, Sydney, Australia

784 SUCCESS SURGERY FOR SPINAL STENOSIS - PROTOCOL OF A RANDOMISED PLACEBO-CONTROLLED TRIAL OF SURGICAL DECOMPRESSION

M. L. FERREIRA1, I. Harris2, J. Latimer3, D. Anderson1, G. Davis4, R. Buchbinder5; 1The Univ. of Sydney, St Leonards, Australia, 2Faculty of Med., Univ. of New South Wales, Sydney, Australia, 3Sch. of Publ. Hlth., The Univ. of Sydney, Sydney, Australia, 4Cabrini Hosp., Melbourne, Australia, 5Dept. of Epidemiology and Preventive Med., Monash Univ., Melbourne, Australia

785 QUANTITATIVE CARTILAGE THICKNESS CHANGE IN RADIOGRAPHICALLY NORMAL KNEES WITH AND WITHOUT OA RISK FACTORS - DATA FROM THE OAI

F. Eckstein1,2, S. Mascheck2,1, L. Sharma3, K. C. Kwoh4, W. Wirth1,2; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics GmbH, Ainring, Germany, 3Northwestern Univ., Chicago, IL, 4Univ. of Arizona Coll. of Med., Tucson, AZ

786 AGE AT PEAK HEIGHT VELOCITY IS RELATED TO PROXIMAL FEMUR SHAPE IN ADOLESCENTS M. Frysz1, L. Howe1, D-Z. Kounali1, J. Gregory2, R. J. Barr3, R. M. Aspden2, L. Paternoster1, J. H. Tobias1; 1Univ. of Bristol, Bristol, United Kingdom, 2Univ. of

Aberdeen, Aberdeen, United Kingdom, 3Univ. of Dundee, Dundee, United Kingdom

IMAGING: JOINT MORPHOMETRY787 A NOVEL METHOD FOR ASSESSING PROXIMAL TIBIOFIBULAR JOINT ON MAGNETIC RESONANCE IMAGES IN PATIENTS WITH KNEE

OSTEOARTHRITIS Z. Zhu, Jr.1,2, J. Chang, Jr.1, Z. Liao1, M. Lu, Jr.1, W. Han, Jr.1, T. Winzenberg, IV1, A. Wluka, IV1, F. Cicuttini, V1, C. Ding, V1, C. Ding, V1; 1Menzies Inst. for Med.

Res., Hobart, Australia, 2Clinical Res. Ctr., Zhujiang Hosp., Southern Med. Univ., Guangzhou, China

788 MORPHOLOGICAL STUDY OF APPLICATION OF METHODS OF TEXTURE ANALYSIS OF IMAGES SUBCHONDRAL BONE IN OSTEOARTHRITIS

M. A. Kabalyk; Pacific State Med. Univ., Vladivostok, Russian Federation

789 CARTILAGE CAVITY - QUANTIFICATION OF CARTILAGE LESIONS FROM PROOF AND OAI KNEE MRI E. B. Dam1, J. Runhaar2; 1Univ. of Copenhagen, Copenhagen, Denmark, 2Erasmus Univ. Med. Ctr., Rotterdam, Netherlands

790 PROTEOGLYCAN DENSITY OF THE TALAR ARTICULAR CARTILAGE IS REDUCED IN THOSE WITH CHRONIC ANKLE INSTABILITY E. A. Wikstrom, K. Song, B. G. Pietrosimone; UNC - Chapel Hill, Chapel Hill, NC

82 | FINAL PROGRAM

791 ASSOCIATIONS BETWEEN ULTRASOUNDFEATURES AND PAIN ACROSS HAND OSTEOARTHRITIS PHENOTYPES C. M. Fjellstad, A. Mathiessen, B. Slatkowsky-Christensen, M. Gloersen, T. K. Kvien, H. B. Hammer, I. K. Haugen; Diakonhjemmet Hosp., Oslo, Norway

IMAGING: HAND, SPINE, SHOULDER, OTHER792 MEASUREMENTS OF METACARPAL LENGTH AND CORTICAL THICKNESS: A LONGITUDINAL ASSESSMENT OF HAND RADIOGRAPHS

FROM THE OSTEOARTHRITIS INITIATIVE. J. Duryea1, J. B. Driban2, M. Roberts3, C. Eaton3, T. E. McAlindon2; 1Brigham and Women’s Hosp., Boston, MA, 2Tufts Med. Ctr., Boston, MA, 3Alpert Med. Sch.

of Brown Univ., Pawtucket, RI

793 CONSTRUCT VALIDITY OF MUSCULOSKELETAL ULTRASOUND IN THUMB-BASE OSTEOARTHRITIS: COMPARISON WITH CLINICAL, FUNCTIONAL AND RADIOLOGICAL FINDINGS

W-M. Oo1, L. A. Deveza1, V. Duong1, K. Fu1, J. M. Linklater2, S. R. Meneses1, E. A. Riordan1, D. J. Hunter1; 1Rheumatology Dept., Royal North Shore Hosp. and Inst. of Bone and Joint Res., Kolling Inst., Univ. of Sydney, Sydney, NSW, Australia, 2Dept. of Musculoskeletal Imaging, Castlereagh Sports Imaging Ctr., St. Leonards, Sydney, NSW, Australia

794 PHOSPHOTUNGSTIC ACID-ENHANCED MICRO COMPUTED TOMOGRAPHY FOR THREE-DIMENSIONAL VISUALIZATION AND ANALYSIS OF COLLAGEN DISTRIBUTION IN HUMAN OSTEOCHONDRAL TISSUES

C. Netzer, S. Schären, J. Geurts; Univ. Hosp. of Basel, Basel, Switzerland

795 ASSOCIATIONS BETWEEN RADIOGRAPHIC SPINAL OA ASSESSED USING LANE GRADING AND SPINE SHAPE CHARACTERISED USING STATISTICAL SHAPE MODELLING IN A BRITISH BIRHT COHORT

S. Wilkinson1, A. V. Pavlova1, I. Faliszewski1, F. R. Saunders1, S. G. Muthuri2, R. J. Barr3, R. Hardy2, K. Martin1, D. Kuh2, R. M. Aspden1, R. Cooper2, J. S. Gregory1; 1Univ. of Aberdeen, Aberdeen, United Kingdom, 2MRC Unit for Lifelong Hlth.and Ageing at UCL, London, United Kingdom, 3MEMO Res. Univ. of Dundee, Dundee, United Kingdom

796 T2 AND T1RHO MAPPING OF ANKLE CARTILAGE OF FEMALE AND MALE BALLET DANCERS S. Horiuchi1, H. J. Yu1, A. Luk1, A. Rudd1, J. Ton1, E. Kuoy1, J. Russell2, K. Sharp1, H. Yoshioka1; 1Univ. of California, Irvine, CA, 2Ohio Univ., Athens, OH

797 SENSITIVITY TO STRUCTURAL CHANGE IN OSTEOARTHRITIS IS GREATEST IN KNEES WITH LOW MININIMUM JSW (<2mm) - DATA FROM THE OAI W. Wirth1,2, M. C. Nevitt3, D. J. Hunter4, L. Sharma5, C. K. Kwoh6, S. Maschek2, F. Eckstein1,2; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics GmbH,

Ainring, Germany, 3Univ. of California San Francisco, San Francisco, CA, 4Rheumatology Dept., Inst. of Bone and Joint Res., Univ. of Sydney, Sydney, Australia, 5Feinberg Sch. of Med., Northwestern Univ., Chicago, IL, 6Univ. of Arizona Arthritis Ctr., Univ. of Arizona Coll. of Med., Tucson, AZ

798 DOES RADIOGRAPHIC STATUS OF THE CONTRALATERAL KNEE IMPACT CARTILAGE THICKNESS CHANGE IN RADIOGRAPHICALLY NORMAL KNEES -DATA FROM THE OSTEOARTHRITIS INITIATIVE

S. Mascheck1,2, W. Wirth1,2, G. N. Duda3, L. Sharma4, F. Eckstein1,2; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics GmbH, Ainring, Germany, 3Charité, Berlin, Germany, 4Northwestern Univ., Chicago, IL

IMAGING: KNEE & HIP799 TEXTURE ANALYSIS OF KNEE PATHOLOGY FOR THE DIAGNOSIS OF RADIOGRAPHIC OSTEOARTHRITIS J. P. Blair1, S. Bierma-Zeinstra2, H. Bay Nielsen1, A-C. Bay-Jensen3, E. B. Dam4; 1Nordic BioSci. ProScion, Copenhagen, Denmark, 2Erasmus MC, Rotterdam,

Denmark, 3Nordic BioSci., Copenhagen, Denmark, 4Biomediq, Copenhagen, Denmark

800 AUTOMATIC KNEE KELLGREN LAWRENCE GRADING WITH ARTIFICIAL INTELLIGENCE B. D. Norman, V. Pedoia, A. Noworolski, T. M. Link, S. Majumdar; Univ. of California San Francisco, San Francisco, CA

801 ASSOCIATIONS BETWEEN RADIOGRAPHIC HIP OA ASSESSED USING KELLGREN-LAWRENCE GRADING AND HIP SHAPE CHARACTERISED USING STATISTICAL SHAPE MODELLING IN A BRITISH BIRTH COHORT

I. Faliszewski1, F. R. Saunders1, S. Wilkinson1, A. V. Pavlova1, S. G. Muthuri2, R. J. Barr3, R. Hardy2, K. Martin1, D. Kuh2, R. M. Aspden1, R. Cooper2, J. S. Gregory1; 1Univ. of Aberdeen, Aberdeen, United Kingdom, 2MRC Unit for Lifelong Hlth.and Ageing at UCL, London, United Kingdom, 3MEMO Res. Univ. of Dundee, Dundee, United Kingdom

802 TRADITIONAL MECHANICAL AND PATIENT FACTORS HAVE NEGLIGIBLE EFFECTS ON CARTILAGE THICKNESS OUTSIDE OF OA DISEASE STATUS: A STUDY USING ACCURATE 3D MRI DATA FROM 9,592 NORMAL AND OSTEOARTHRITIC KNEES

M. A. Bowes1, O. A. Alabas2, E. M. Hensor2, G. Guillard1, A. Brett1, S. R. Kingsbury2, P. G. Conaghan2; 1Imorphics Ltd, Manchester, United Kingdom, 2Univ. of Leeds, Leeds, United Kingdom

83 | FINAL PROGRAM

803 AUTOMATIC SEGMENTATION OF HIP CARTILAGE WITH DEEP CONVOLUTIONAL NEURAL NETS FOR THE EVALUATION OF ACETABULUM AND FEMORAL T1ρ AND T2 RELAXATION TIMES.

M. Girard, V. Pedoia, B. Norman, J. Rossi-Devries, S. Majumdar; Univ. of California, San Francisco, San Francisco, CA

804 ARTIFICIAL INTELLIGENCE PIPELINE FOR MENISCUS SEGMENTATION AND LESION DETECTION B. D. Norman, V. Pedoia, T. M. Link, S. Majumdar; Univ. of California San Francisco, San Francisco, CA

805 AUTOMATED STAGING OF KNEE OSTEOARTHRITIS SEVERITY USING DEEP NEURAL NETWORKS S. Suresha, L. Kidziński, E. Halilaj, G. E. Gold, S. L. Delp; Stanford Univ., Palo Alto, CA

806 DETECTION OF MENISCAL EXTRUSION: COMPARISON OF STANDING COMPUTED TOMOGRAPHY TO NON-LOADED MAGNETIC RESONANCE IMAGING

N. A. Segal1, K. G. Rabe1, J. A. Lynch2, B. M. Everist1, F. Roemer3, A. Guermazi3; 1Univ. of Kansas Med. Ctr., Kansas City, KS, 2Univ. of California-San Francisco, San Francisco, CA, 3Boston Univ., Boston, MA

807 IS BETA ANGLE THE NEW ALPHA ANGLE? RELIABILITY AND CORRELATION WITH CARTILAGE HEALTH IN FEMOROACETABULAR IMPINGEMENT SYNDROME

L. E. Diamond1, N. J. Murphy2,3, J. Eyles2,3, Y-J. Kim4, J. M. Linklater5, L. Spiers6, D. Hunter2,3; 1Menzies Hlth.Inst. Queensland, Sch. of Allied Hlth.Sci., Griffith Univ., Gold Coast, Australia, 2Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., Univ. of Sydney, Sydney, Australia, 3Dept. of Rheumatology, Royal North Shore Hosp., Sydney, Australia, 4Dept. of Orthopedic Surgery, Boston Children’s Hosp., Boston, MA, 5Dept. of Musculoskeletal Imaging, Castlereagh Sports Imaging Ctr., Syndey, Australia, 6Ctr. for Hlth., Exercise and Sports Med., Dept. of Physiotherapy, Univ. of Melbourne, Melbourne, Australia

808 THE MORPHOLOGICAL PARAMETERS OF PROXIMAL TIBIOFIBULAR JOINT PREDICT INCIDENT RADIOGRAPHIC OSTEOARTHRITIS: DATA FROM OSTEOARTHRITIS INITIATIVE

Z. Zhu, Jr.1,2, J. Chang, Jr.1, G. Wang, Jr.1, M. Lu, Jr.1, M. Lu, Jr.1, W. Han, Jr.1, S. Zheng, Jr.1, T. Meng, Jr.1, F. Wu, Jr.1, D. Jiang, IV1,3, M. J. Hannon, V4, D. J. Hunter, V5, C. Ding, V1,6; 1Menzies Inst. for Med. Res., Hobart, Australia, 2Clinical Res. Ctr., Zhujiang Hosp., Southern Med. Univ., Guangzhou, China, 3Dept. of Engineering Physics, Univ. of Tasmania, Hobart, Australia, 4Devision of Rheumatology and Clinical Immunology, Univ. of Pittsburgh Sch. of Med., Pittsburgh, PA, 5Dept. of Rheumatology, Royal North Shore Hosp. and Inst. of Bone and Join Res., Sydney, Australia, 6Clinical Res. Ctr., Zhujiang Hosp., Southern Med. Univ., Guangzhou, Australia

809 ACCELERATED KNEE OSTEOARTHRITIS IS NEARLY ALWAYS ASSOCIATED WITH MENISCAL BREAKDOWN: DATA FROM THE OSTEOARTHRITIS INITIATIVE

S. C. Foreman1, J. Neumann1, G. B. Joseph1, M. C. Nevitt2, F. Liu2, J. A. Lynch2, C. E. McCulloch2, N. E. Lane3, T. M. Link1; 1Dept. of Radiology and BioMed. Imaging, UCSF, San Francisco, CA, 2Dept. of Epidemiology and Biostatistics, UCSF, San Francisco, CA, 3Dept. of Rheumatology, UC Davis, Davis, CA

810 THE RELATIONSHIP BETWEEN TWO DIFFERENT MEASURES OF OSTEOARTHRITIS BONE PATHOLOGY, BONE MARROW LESIONS AND 3D BONE SHAPE: DATA FROM THE OSTEOARTHRITIS INITIATIVE

B. Dube1, M. A. Bowes2, A. J. Barr1, E. M. Hensor1, S. R. Kingsbury1, P. G. Conaghan1; 1Leeds Inst. of Rheumatic & Musculoskeletal Med., Leeds, United Kingdom, 2Imorphics, Manchester, United Kingdom

811 SEVERE KNEE OSTEOARTHRITIS PATIENTS SHOW MORE FEMORAL CORONAL BOWING THAN MODERATE KNEE OSTEOARTHRITIS PATIENTS- A STUDY USING THREE DIMENSIONAL COMPUTED TOMOGRAPHY

H. Shimosawa1,2, T. Nagura1, S. Kobayashi1, K. Harato1, M. Nakamura1, M. Matsumoto1, Y. Niki1; 1Keio Univ., Tokyo, Japan, 2SaiseikaiYokohamashi Nanbu Hosp., Yokohama, Japan

812 ULTRASONOGRAPHY OF THE LATE-STAGE KNEE OSTEOARTHRITIS PRIOR TOTAL KNEE ARTHROPLASTY: COMPARISON OF THE ULTRASONOGRAPHIC, RADIOGRAPHIC AND INTRA-OPERATIVE FINDINGS

M. T. Nevalainen1, J. Pylväläinen2, K. Kauppinen1, K. Pamilo3, M. Pesola3, J. Koski4, M. Haapea5, S. Saarakkala5; 1Oulu Univ. Hosp., Oulu, Finland, 2Helsinki Univ. Hosp., Helsinki, Finland, 3Central Finland Central Hosp., Jyväskylä, Finland, 4Mikkeli Central Hosp., Mikkeli, Finland, 5Univ. of Oulu, Oulu, Finland

813 FULLY AUTOMATIC SEMANTIC SEGMENTATION OF KNEE PLAIN RADIOGRAPHS USING CONVOLUTIONAL DEEP NEURAL NETWORKS A. Tiulpin1, J. Thevenot1, S. Saarakkala1,2; 1Univ. of Oulu, Oulu, Finland, 2Oulu Univ. Hosp., Oulu, Finland

814 POSTOPERATIVE MEDIAL MENISCAL SHIFT IN THE KNEE-FLEXED POSITION FOLLOWING MENISCAL REPAIR ASSOCIATED WITH ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION

Y. Okazaki, T. Furumatsu, S. Miyazawa, T. Hino, Y. Kamatsuki, T. Ozaki; Dept. of Orthopaedic Surgery, Okayama Univ. Graduate Sch. of Med., Okayama,Japan, Japan

815 SUPEROLATERAL HOFFA’S FAT PAD (SHFP) EDEMA AND PATELLAR CARTILAGE VOLUME LOSS: QUANTITATIVE ANALYSIS USING LONGITUDINAL DATA FROM THE FOUNDATION FOR THE NATIONAL INSTITUTE OF HEALTH (FNIH) OSTEOARTHRITIS BIOMARKERS CONSORTIUM

A. Haj-Mirzaian1, A. Guermazi2, N. Hafezi-Nejad3, C. Sereni4, M. Hakky5, D. Hunter6, B. Zikria1, F. Roemer2, S. Demehri1; 1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, 2Boston Univ. Sch. of Med., Boston, MA, 3Univ. System of Maryland, Baltimore, MD, 4Univ. of Massachusetts Med. Sch., Boston, MA, 5Florida Hosp., Maitland, FL, 6Univ. of Sydney, and Rheumatology Dept., Royal North Shore Hosp. Sydney,, Sydney, Australia

84 | FINAL PROGRAM

816 FULLY AUTOMATIC KNEE ARTICULAR CARTILAGE SEGMENTATION FROM MR IMAGES: MULTILEVEL IMAGE PROCESSING APPROACH A. P. Gandhamal1,2, S. N. Talbar1, S. S. Gajre1, A. M. Hani2, R. Razak3, D. Kumar2,4; 1SGGS Inst. of Engineering and Technology, Nanded, India, 2Universiti Teknologi

Petronas, Ipoh, Malaysia, 3Dept. of Rheumatology, Hosp. Pantai, Ipoh, Malaysia, 4Univ. of Otago, Dunedin, New Zealand

817 HIP MORPHOLOGY AND PATIENT FACTORS ASSOCIATED WITH SEVERITY OF HIP SYMPTOMS IN FEMOROACETABULAR IMPINGEMENT N. J. Murphy1,2, L. E. Diamond3, J. Eyles1,2, Y. J. Kim4, J. M. Linklater5, L. Spiers6, D. J. Hunter1,2; 1Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., Univ. of

Sydney, St Leonards, Australia, 2Dept. of Rheumatology, Royal North Shore Hosp., St Leonards, Australia, 3Menzies Hlth.Inst. Queensland, Sch. of Allied Hlth.Sci., Griffith Univ., Griffith University, Australia, 4Dept. of Orthopedic Surgery, Boston Children’s Hosp., Boston, MA, 5Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., Univ. of SydneyDept. of Musculoskeletal Imaging, Castlereagh Sports Imaging Ctr., St Leonards, Australia, 6Ctr. for Hlth., Exercise and Sports Med., Dept. of Physiotherapy, Univ. of Melbourne, Melbourne, Australia

818 EVALUATION OF KNEE CARTILAGE USING THREE-DIMENSIONAL ISOTROPIC MAGNETIC RESONANCE IMAGING: A SYSTEMATIC REVIEW AND META-ANALYSIS

D. Shakoor, S. Demehri; Johns Hopkins Univ. Sch. of Med., Baltimore, MD

819 INCREASED FEMORAL ANTEVERSION AND ALPHA ANGLE ARE ASSOCIATED WITH LOWER DELAYED GADOLINIUM ENHANCED MRI OF CARTILAGE SCORE IN FEMOROACETABULAR IMPINGEMENT

N. J. Murphy1,2, L. E. Diamond3, J. Eyles1,2, Y. J. Kim4, J. M. Linklater5, L. Spiers6, D. J. Hunter1,2; 1Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., Univ. of Sydney, St Leonards, Australia, 2Dept. of Rheumatology, Royal North Shore Hosp., St Leonards, Australia, 3Menzies Hlth.Inst. Queensland, Sch. of Allied Hlth.Sci., Griffith Univ., Griffith University, Australia, 4Dept. of Orthopedic Surgery, Boston Children’s Hosp., Boston, MA, 5Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., Univ. of SydneyDept. of Musculoskeletal Imaging, Castlereagh Sports Imaging Ctr., St Leonards, Australia, 6Kolling Inst. of Med. Res., Inst. of Bone and Joint Res., Univ. of SydneyCtr. for Hlth., Exercise and Sports Med., Dept. of Physiotherapy, Univ. of Melbourne, Melbourne, Australia

820 THE RELATIONSHIP BETWEEN ACCURATE 3D MEASUREMENTS OF CARTILAGE THICKNESS AND RADIOGRAPHIC JOINT SPACE WIDTH: DATA FROM THE OSTEOARTHRITIS INITIATIVE

M. A. Bowes1, O. Alabas2, G. Guillard1, A. Brett1, P. G. Conaghan2; 1Imorphics Ltd, Manchester, United Kingdom, 2Univ. of Leeds, Leeds, United Kingdom

821 MULTI-SCALE HISTOPATHOLOGY IDENTIFIES INHOMOGENEOUS AND ANISOTROPIC STRUCTURE OF CARTILAGE LESIONS IN HUMAN KNEE FEMORAL CONDYLE

F. H. Hsu, L. P. Liu, H. Qiu, N. Chang, B. L. Schumacher, K. Masuda, R. Sah; Univ. of California, San Diego, La Jolla, CA

822 COMPARTMENTAL DISTRIBUTION OF OSTEOARTHRITIC FEATURES AMONGST PEOPLE WITH CHRONIC KNEE PAIN: A MAGNETIC RESONANCE IMAGING STUDY

S. Kobayashi, E. Pappas, M. Simic, M. Fransen, K. Refshauge; Univ. of Sydney, Sydney, Australia

823 RELATIONSHIP OF THIGH INTERMUSCULAR AND SUBCUTANEOUS FAT CONTENT TO KNEE OA STATUS, SEX AND THE BODY MASS INDEX- DATA FROM THE OAI

T. Dannhauer1,2, E. Steidle-Kloc1, W. Wirth1,2, F. Eckstein1,2; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics, Ainring, Germany

824 FEATURE-SPECIFIC HISTOPATHOLOGICAL GRADING OF MURINE CARTILAGE DEGENERATION L. P. Liu1, F. H. Hsu1, M. K. Lotz2, R. L. Sah1; 1Univ. of California, San Diego, La Jolla, CA, 2The Scripps Res. Inst., La Jolla, CA

825 EFFECT OF INCLINED MEDIAL PROXIMAL TIBIAL ARTICULATION ON VARUS ALIGNMENT IN KNEE OSTEOARTHRITIS T. Mochizuki1, O. Tanifuji1, Y. Koga2, T. Sato3, K. Kobayashi1, G. Omori4, N. Endo1; 1Niigata Univ., Niigata City, Japan, 2Hokuetsu Hosp., Niigata City, Japan,

3Niigata Med. Ctr., Niigata City, Japan, 4Niigata Univ. of Hlth.and Welfare, Niigata City, Japan

826 VISUALIZATION OF EARLY COLLAGEN FIBER ARCHITECTURE CHANGES IN HUMAN CARTILAGE AND DEVELOPING OSTEOPHYTES S. M. Walzer1, B. Hager2,3, S. Toegel1, V. Juras2,3, D. Weinmann1, B. Kubista1, R. Windhager1, S. Trattnig2,3; 1Med. Univ. Vienna, Dept. of Orthopaedic Surgery,

Vienna, Austria, 2Med. Univ. Vienna, High Field MR Ctr., Dept. of BioMed. Imaging and Image-guided Therapy, Vienna, Austria, 3CD Lab. for Clinical Molecular MR Imaging, Vienna, Austria

827 VALIDATION OF A 3D THIGH MUSCLE AND ADIPOSE TISSUE SEGMENTATION METHOD USING STATISTICAL SHAPE MODELS J. Kemnitz1, F. Eckstein1,2, A. G. Culvenor1,3, A. Ruhdorfer1,4, T. Dannhauer1, S. Ring-Dimitriou5, A. M. Sänger5, W. Wirth1,2; 1Paracelsus Med. Univ., Salzburg,

Austria, 2Chondrometrics GmbH, Ainring, Germany, 3La Trobe Univ., Sch. of Allied Hlth., Melbourne, Australia, 4Trauma Dept., Unfallkrankenhaus, Salzburg, Austria, 5Paris Lodron Univ., Salzburg, Austria

828 FEMORAL BONE TEXTURE DIFFERS BETWEEN SUBJECTS WITH AND WITHOUT RADIOGRAPHIC HIP OSTEOARTHRITIS, DATA FROM CHECK J. Hirvasniemi1, W. P. Gielis2, W. E. van Spil2, H. Weinans2, J. Heikkilä1; 1Univ. of Oulu, Oulu, Finland, 2UMC Utrecht, Utrecht, Netherlands

829 QUANTIFICATION OF BONE SHAPE AND CARTILAGE THICKNESS USING 3D MRI AND THEIR INTERRELATIONSHIP IN OSTEOARTHRITIC KNEES OF A CHINESE COHORT

Q. Zhong1,2, V. Pedoia2, X. Li3, J. Lin1; 1Peking Univ. People’s Hosp., Beijing, China, 2Univ. of California San Francisco, San Francisco, CA, 3Cleveland Clinic, Cleveland, OH

85 | FINAL PROGRAM

830 THREE-DIMENSIONAL CORTICAL THICKNESS IN FEMORAL DIAPHYSIS FOR EALTHY ELDERLY AND OSTEOARTHRITIC KNEES IN WOMEN S. Hokari, T. Mochizuki, O. Tanifuji; Niigata Univ. Med. and Dental Hosp., Niigata, Japan

831 VALIDATION OF KNEE OSTEOARTHRITIS CASE IDENTIFICATION ALGORITHMS IN THE HEALTH IMPROVEMENT NETWORK D. Felson1, S. Li1, K. I. Thomas2, C. Peloquin1, M. Dubreuil1; 1Boston Univ. Sch. of Med., Boston, MA, 2Boston Med. Ctr., Boston, MA

832 MAGNETIC RESONANCE IMAGING PARAMETER MAPPING IN EX VIVO HUMAN MENISCI E. Olsson1,2, E. Folkesson2,3, P. Peterson1,4, P. Onnerfjord3, M. Englund2, J. Svensson5,1; 1Med. Radiation Physics, Dept. of Translational Med., Lund Univ., Malmö, Sweden,

2Orthopedics, Dept. of Clinical Sci., Lund Univ., Lund, Sweden, 3Rheumatology and Molecular Skeletal Biology, Dept. of Clinical Sci., Lund Univ., Lund, Sweden, 4Radiation Physics, Dept. of Oncology and Radiation Physics, Skane Univ. Hosp., Malmö, Sweden, 5Med. Imaging and Physiology, Skane Univ. Hosp., Lund, Sweden

833 IMPROVING DIAGNOSTICS OF FEMOROACETABULAR IMPINGEMENT - A FEASIBILITY STUDY J. E. Naili1, E. Gutierrez-Farewik2, A. Stålman3,4, A. Valentin3,5, M. Skorpil6, L. Weidenhielm6; 1Karolinska Inst.t, Dept. of Women’s and Children’s Hlth., Stockholm,

Sweden, 2Royal Inst. of Technology, KTH Mechanics, KTH BioMEx Ctr., Stockholm, Sweden, 3Karolinska Inst.t, Dept. of Molecular Med. and Surgery, Stockholm Sports Trauma Res. Ctr., Stockholm, Sweden, 4Capio Artro Clinic, Sophiahemmet, Stockholm, Sweden, 5Elisabethsjukhuset, Uppsala, Sweden, 6Karolinska Inst.t, Dept. of Molecular Med. and Surgery, Stockholm, Sweden

834 SPATIAL VARIATIONS IN NON-OSTEOARTHRITIC TIBIAL CARTILAGE T2 RELAXATION TIME AND CARTILAGE THICKNESS S. N. Edd, H. Babel, L. C. Pereira, B. M. Jolles, P. Omoumi, J. Favre; Univ. Hosp. of Lausanne (CHUV), Lausanne, Switzerland

835 ASSOCIATIONS AMONG A SPECTRUM OF KNEE OSTEOARTHRITIS FEATURES ON MRI INFORM ABOUT POTENTIAL PATHOGENIC MECHANISMS, DATA FROM THE OAI/FNIH BIOMARKERS CONSORTIUM

W. E. van Spil1, L. A. Deveza2, D. J. Hunter2; 1Univ. Med. Ctr. Utrecht, Utrecht, Netherlands, 2Royal North Shore Hosp. and Inst. of Bone and Joint Res., Kolling Inst., Sydney Univ., Sydney, Australia

836 DELAYED GADOLINIUM ENHANCED MRI OF MENISCI AND CARTILAGE (DGEMRIM/DGEMRIC) IN OVERWEIGHT PATIENTS WITH KNEE OSTEOARTHRITIS -A CROSS SECTIONAL STUDY OF 86 OVERWEIGHT PATIENTS WITH INTRAARTICULAR ADMINISTERED GADOLINIUM CONTRAST

S. Hangaard1,2, H. Gudbergsen1, C. L. Daugaard1,2, H. Bliddal1, J. D. Nybing2, M. T. Nieminen3,4, V. Casula3,5, C-J. Tiderius6, M. Boesen2; 1Parker Inst., Frederiksberg, Denmark, 2Dept. of Radiology, Bispebjerg and Frederiksberg Hospital, Denmark, 3Res. Unit of Med. Imaging, Physics and Technology, University of Oulu, Finland, 4Dept. of Diagnostic Radiology, Oulu University Hospital, Finland, 5Med. Res. Ctr., University of Oulu and Oulu University Hospital, Finland, 6Dept. of orthopedics, Clinical Sci. Lund, Lund University, Sweden

837 REPEATABILITY AND DISCRIMINATION VALIDITY OF CARTILAGE IMAGING BIOMARKERS FOR EXPERIMENTAL MEDICINE STUDIES OF KNEE OSTEOARTHRITIS

J. W. MacKay1, T. D. Turmezei2, J. Kaggie1, A. R. Morgan3, R. L. Janiczek3, W. Khan1, S. McDonnell1, M. J. Graves1, G. M. Treece1, A. W. McCaskie1, F. J. GIlbert1; 1Univ. of Cambridge, Cambridge, United Kingdom, 2Norfolk & Norwich Univ. Hosp., Norwich, United Kingdom, 3GlaxoSmithKline, Stevenage, United Kingdom

838 MRI-DETECTED SUBCHONDRAL BONE MARROW LESIONS: DOES USING TWO MRI SEQUENCES IMPROVE DETECTION AND CLINICAL RELEVANCE?

S. Mattap1, D. Aitken1, K. Wills1, L. Laslett1, C. Ding1, J-P. Pelletier2, J. Martel-Pelletier2, S. E. Graves3, M. Lorimer4, F. Cicuttini5, G. Jones1; 1Menzies Inst. for Med. Res., Univ. of Tasmania, Hobart, Australia, 2Osteoarthritis Res. Unit, Univ. of Montreal Hosp. Res. Ctr. (CRCHUM), Montreal, QC, Canada, 3Australian Orthopaedic Association Natl. Joint Replacement Registry (AOANJRR), Adelaide, Australia, 4South Australian Hlth.and Med. Res. Inst. (SAHMRI), Adelaide, Australia, 5Dept. of Epidemiology and Preventive Med., Monash Univ., Melbourne, Australia

839 THE REPRODUCIBILITY OF T2 RELAXATION TIME MEASUREMENT OF KNEE CARTILAGE IN WOMEN AGED OVER 50 C. Hartley1, R. Kerslake2, J. Folland1, K. Brooke-Wavell1; 1Loughborough Univ., Loughborough, United Kingdom, 2Nottingham Univ. Hosp. Trust, Nottingham,

United Kingdom

840 LONGITUDINAL SURVEY FOR HIGH DENSITY MINERALISED PROTRUSIONS IDENTIFIED BY 3D DESS MRI IN PATIENTS OF THE OSTEOARTHRITIS INITIATIVE

N. P. Thomas1, N. Jeffery1, L. R. Ranganath1, A. Boyde2, J. A. Gallagher1; 1Univ. of Liverpool, Liverpool, United Kingdom, 2Queen Mary Univ. of London, London, United Kingdom

841 FAST-FIELD CYCLING MAGNETIC RESONANCE IMAGING - DEVELOPING A NEW BIOMARKER FOR EARLY OSTEOARTHRITIS OF THE KNEE. I. A. Rankin1, L. M. Broche2, R. James2, B. W. Kennedy1, C. F. MacEachern1, H. Rehman1, P. K. Myint2, D. J. Lurie2, G. P. Ashcroft1; 1NHS Grampian, Aberdeen,

United Kingdom, 2Univ. of Aberdeen, Aberdeen, United Kingdom

842 A STRUCTURAL PROGRESSOR DEFINITION BASED ON LOCATION-INDEPENDENT FEMOROTIBIAL CARTILAGE LOSS - COMPARISON WITH LOCATION-SPECIFIC MRI AND RADIOGRAPHIC JOINT SPACE WIDTH

W. Wirth1,2, S. Maschek1,2, F. Eckstein1,2; 1Paracelsus Med. Univ., Salzburg, Austria, 2Chondrometrics Gmbh, Ainring, Germany

86 | FINAL PROGRAM

843 FAST TISSUE REGENERATION OF KNEE OSTEOARTHRITIS INDUCED BY NANOPARTICLES IN RESPONSE TO MANIPULATION OF pH L. Zerrillo1,2, I. Que1, A. Chan2,3, F. Galli4, R. Censi5, P. Di Martino6, L. J. Cruz1; 1LUMC, LEIDEN, Netherlands, 2Percuros, Enschede, Netherlands, 3Lumc, Leiden,

Netherlands, 4Leiden Inst. of Physics, LEIDEN, Netherlands, 5Univ. of Camerino, Camerino, Italy, 6Univ. of Camerino, LEIDEN, Italy

844 FLUORESCENCE-BASED CONFOCAL LASER ENDOMICROSCOPY FOR IMAGING OSTEOARTHRITIS I. Que, L. Zerrillo, Y. Li, A. B. Chan, L. J. Cruz; LUMC, Leiden, Netherlands

845 FULLY AUTOMATIC DEEP LEARNING BASED SEGMENTATION OF BONE-CARTILAGE INTERFACE FROM MICRO-CT IMAGES OF HUMAN OSTEOCHONDRAL SAMPLES

T. Frondelius1, A. Tiulpin1, P. Lehenkari1,2, H. J. Nieminen1,3, S. Saarakkala1,2; 1Univ. of Oulu, Oulu, Finland, 2Oulu Univ. Hosp., Oulu, Finland, 3Aalto Univ., Espoo, Finland

IMAGING: PRECLINICAL MODELS846 SECOND HARMONIC GENERATION IMAGING REVEALS ALTERATIONS OF COLLAGEN FIBERS THAT CORRELATE WITH SYNOVITIS AND

CARTILAGE DAMAGE IN EARLY EXPERIMENTAL OSTEOARTHRITIS C. Hui Mingalone1, Z. Liu2, J. Hollander1, K. Garvey1, A. Gibson1, R. Banks1, M. Zhang1, T. McAlindon1, H. Nielsen1, I. Georgakoudi3, L. Zeng1; 1Tufts Univ. Sch. of

Med., Boston, MA, 2Tufts Univ. Sch. of Engineering, Medford, MA, 3Tufts Univ. Sch. of Engineering, Boston, MA

847 CLINICAL, ARTHROSCOPIC AND KINEMATIC CORRELATES OF OSTEOARTHRITIS PROGRESSION IN SHEEP M. Hurtig, E. Cummins, E. Lamoure, C. Flynn; Univ. of Guelph, Guelph, ON, Canada

848 SCREENING FOR SELECTIVE AGGRECANASE SUBSTRATES TO DETECT EARLY PROTEOLYTIC EVENTS IN CARTILAGE DEGRADATION M. M. Fowkes1, M. P. Meldal2, T. L. Vincent1, N. H. Lim1; 1Kennedy Inst., Univ. of Oxford, Oxford, United Kingdom, 2Dept. of Chemistry & Nano Sci. Ctr., Univ.

of Copenhagen, Copenhagen, Denmark

849 IMAGING AND FUNCTIONAL ASSESSMENT OF MEDIAL MENISCUS SURGICAL DESTABILIZATION ANIMAL MODEL FOR OSTEOARTHRITIS F. B. Dias de Oliveira1, J. G. Souza2, O. Furiama1, M. Ferretti1, E. Antoniolli1; 1Hosp. Israelita Albert Einstein, São Paulo, Brazil, 2Inst. Butantan, São Paulo, Brazil

850 SYNCHROTRON X-RAY IMAGING APPLICATIONS IN OSTEOARTHRITIS A. Panahifar1, D. Chapman2, D. M. Cooper1; 1Univ. of Saskatchewan, Saskatoon, SK, Canada, 2Univ. of Saskatchewan, and Canadian Light Source, Saskatoon, SK,

Canada

851 QUALIFICATION OF THE ULTRASOUND IMAGING TECHNIQUE TO ESTIMATE THE OARSI REFERENCE HISTOLOGICAL SCORE IN ORDER TO ASSESS THE OSTEOARTHRITIS GRADE OF CARTILAGE IN THE CONDYLAR FEMORAL ARTICULATION

A. Gleyzolle1, B. Boisson2, A. Lienhard3, G. Custillon3, C. Hughes4, R. Pailhé1, A. Moreau-Gaudry1; 1Univ. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP*, TIMC-IMAG, F-38000 Grenoble, France Institute of Engineering Univ. Grenoble Alpes, 2CHU Grenoble Alpes, Département d’Anatomie et de Cytologie Pathologiques, F-38000 Grenoble, France, 3Cartimage Medical SAS, F-38000 Grenoble, France, 4Univ. Grenoble Alpes, INSERM, CHU Grenoble Alpes, CIC 1406 (Innovative Technology), F-38000 Grenoble, France

852 MONOSODIUM IODOACETATE INDUCED OSTEOARTHRITIS IN THE KNEE JOINT OF GROWING RATS: EFFECTS ON BONE AS MEASURED BY MICRO-COMPUTED TOMOGRAPHY

J. Vaaraniemi, J. Morko, J. Lehtimaki, J. Zdrojewska, Z. Peng, J. M. Halleen; Pharmatest Services Ltd, Turku, Finland