professor of medicine. university of barcelona barcelona ... · scope life span panel member(*)...
TRANSCRIPT
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Jose M Gatell MD, PHD Senior Consultant, Infectious Diseases & AIDS Units. Hospital Clinic
Professor of Medicine. University of Barcelona Barcelona, Spain
[email protected] [email protected]
Review/comparison of current guidelines for ART
Hospital Clínic – Facultad de Medicina (U.B.)Barcelona (España)
Hospital Clínic – Facultad de Medicina (U.B.)Barcelona (España)
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Potential conflicts of interest (April 2018):
Dr. Gatell has received honoraria for lectures or AB or research grants (his institution) from MSD, ViiV, Gilead, and Janssen
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Scope life span panel member(*) GESIDA/PNS Spain 2000-18 always EACS Europe 2005-18 always IAS-USA International 1996-18 2000-10 (JAMA) WHO Developing world DHHS USA
(*) my conflict of interest
Review/comparison of current guidelines for ART
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1. What about guidelines
2. What do we need to know (to guess) before reading
3. When & what to start ART ?
4. Other issues related with ART
5. Other issues related with management of HIV patients
6. Final considerations
Review/comparison of current guidelines for ART
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Organizing a congress and publishing guidelines are one of the justifications, and often the only reason to exist, for the majority of medical societies
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So, it is not a surprise the existence of many different ART guidelines, with different geographical scopes, including countries where access to ART is, even now, difficult
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The content is a mixture of: science (evidence based medicine ?) opinions (expert opinions ?) politics and more….¡¡¡
Review/comparison of current guidelines for ART
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1. What about guidelines
2. What do we need to know (to guess) before reading
3. When & what to start ART ?
4. Other issues related with ART
5. Other issues related with management of HIV patients
6. Final considerations
Review/comparison of current guidelines for ART
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2. What do we need to know (to guess) before reading Who is the promoter/sponsor (a not for profit private body ?, governmental agency ? both ?
Selection & composition of the panel What is the reason/justification Who is the intended audience (doctors ?, patients ?, insurance companies ?,
health authorities ?, all of them ?) What is the geographical scope What is the decision making process Conflicts of interest
Review/comparison of current guidelines for ART
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Review/comparison of current guidelines for ART
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Quite often, panels make decisions (unanimity, consensus or voting) first and then qualify already taken decisions
Review/comparison of current guidelines for ART
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Conflicts of interest do not disappear simply by the fact of disclosing them Governmental agencies by definition have conflicts of interest. But, apparently not for profit, medical societies/associations may also have conflicts of interest There are also academic conflicts of interest. Publishers and journals also have conflicts of interest (IF, citations …)
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1. What about guidelines
2. What do we need to know (to guess) before reading
3. When & what to start ART ?
4. Other issues related with ART
5. Other issues related with management of HIV patients
6. Final considerations
Review/comparison of current guidelines for ART
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Review/comparison of current guidelines for ART
Since year 2005 initial ART was very effective, well tolerated and convenient for the patients Common sense dictated all HIV patients should receive ART irrespective of CD4+ cell count Yet, it took 10 years (up to year 2015) and several millions of dollars to generate evidence to support the common sense
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New
TB & AIDS and non-AIDS
malignancies
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New
EACS & WHO, 2015
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Elite/viremic controllers Do not like ART & CD4+ cell count >350-500 Do we need a resistance test before ART Initiation “same day” ?
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1. What about guidelines
2. What do we need to know (to guess) before reading
3. When & what to start ART ?
4. Other issues related with ART
5. Other issues related with management of HIV patients
6. Final considerations
Review/comparison of current guidelines for ART
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Spain Europe International
USA Developing world
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GESIDA, 2018
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GESIDA, 2019 (forecast)
BIC/FTC/TAF
GESIDA, 2018
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IAS-USA, 2016 DHHS Feb 2018
EACS Oct 2017
RPV
DRV/r/c
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Blasco, Gatell et al. EIMC 2018, in press
010
20
30
40
50
60
70
80
90
100
T F V/F T C + R AL (n = 3 )
T F V/F T C /E VG /c (n = 4 )
AB C /3 T C /D T G (n = 4 )
T F V/F T C + D T G (n = 3 )
T AF /F T C /B IC (n = 2 )
T r ia ls in a n t ire tro v ira l n a ïv e p a t ie n ts (p o o le d a n a ly s is )
P e rc e n ta g e o f re s p o n s e ( IT T e x p o s e d , m is s in g o r N C = F )
RE
GIM
EN
S C
ON
TA
ININ
G I
NS
TI
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pautas debut
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2011
2012
2013
2014
2015
2016
2017
2018
GESIDA/PNS (Sapin) Guidelines (since 2000) Cost-efficacy analysis of recommended regimens
2018, In press
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Blasco, Gatell et al. EIMC 2018
EU
RO
S P
ER
YE
AR
AR
T c
os
t
Co
st
of
init
iat i
ng
AR
T
Co
st
pe
r re
sp
on
de
r
5 5 0 0
6 0 0 0
6 5 0 0
7 0 0 0
7 5 0 0
8 0 0 0
8 5 0 0
9 0 0 0
9 5 0 0
1 0 0 0 0
1 0 5 0 0
1 1 0 0 0
1 1 5 0 0
1 2 0 0 0
1 2 5 0 0
1 3 0 0 0
A B C /3 T C /D T G
T F V /F T C + R A L
T F V /F T C + D T G
T A F /F T C /E V G /c
T F V /F T C + R P V
T F V /F T C /D R V /c
T D F /F T C /D R V /r
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1. What about guidelines
2. What do we need to know (to guess) before reading
3. When & what to start ART ?
4. Other issues related with ART
5. Other issues related with management of HIV patients
6. Final considerations
Review/comparison of current guidelines for ART
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EACS Oct 2017
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yes N=4499
S
Treated type of ART
no I
BLQ 87%
Hospital Clinic. Barcelona. Spain Data on file, 2012
10%
3%
EVOLUTION OF HIV TREATMENT GUIDELINES
From 1990s to 2018
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1. What about guidelines
2. What do we need to know (to guess) before reading
3. When & what to start ART ?
4. Other issues related with ART
5. Other issues related with management of HIV patients
6. Final considerations
Review/comparison of current guidelines for ART
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1. What about guidelines
2. What do we need to know (to guess) before reading
3. When & what to start ART ?
4. Other issues related with ART
5. Other issues related with management of HIV patients
6. Final considerations
Review/comparison of current guidelines for ART
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Recommendations/guidance are pretty similar. May use different wording or different ways of presenting same information May/should go beyond published evidence Use to represent the “minimum” SOC. As such may represent a defense mechanism for prescribers when they need to interact with third party payers (NHS´s in Europe) and developers (pharma companies)
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David Cooper Jürgen Roschtroch Pedro Cahn
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Clinical Group JL Blanco M Laguno
C Cáceres M López-Diéguez
P Callau J Mallolas
M Calvo C Manzardo
S Corral D Martínez
F Etcheverri E Martínez
E Fernández M Martínez
JM Gatell C Mensa
F García A Milinkovic
M Larrousse JM Miró
E Lazzari A Moreno
A León I Pérez
M Loncà L Zamora
Virology Lab M Arnedo
N Boulanger
T Escribá
C García
M García
C Gil
C Hurtado
S Lyonnais
A Merino
G Mirambeau
L Muñoz
Immunology Lab C Alvarez L Miralles
N Climent M Plana
R Fernández C Rovira
T Gallart S Sánchez
A García V Sánchez
J Joseph N Saubí
MJ Maleno S Varea
E Yuste
Clinical Trials
Coordination JA Arnaiz
X Carné
A Cruceta
J Pich
M Sarasa
S Varea
Clinical Institute of Medicine & Dermatology
Infectious Diseases & AIDS Division
External Colaborators J Alcamí
B Autran
M Lederman
D Nixon
G Pantaleo
B Walker
ISCIII
Pharma companies
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JAMA, 2016
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Recomendaciones Gesida 2018
Gesida 2018
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Recomendaciones Gesida 2018
Gesida 2018
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1. European AIDS Clinical Society Guidelines v. 9.0 October 2017. Disponible en: http://www.eacsociety.org/files/guidelines_9.0-english.pdf. Con acceso: febrero 2018.
▼ Este medicamento está sujeto a seguimiento adicional, es prioritaria la notificación de sospechas de reacciones adversas asociadas a este medicamento.
Recomendaciones EACS Nov 2017
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El texto resaltado en amarillo implica cambios vs. la versión anterior de las guías TAF no está comercializado en España como fármaco independiente 3. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents DHHS panel. Disponible en https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Con acceso: febrero 2018.
Recomendaciones DHHS Feb 2018
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51
What about the guidelines ……….
June 2008
Oct. 2011
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