prof. federico bordi - uniroma1.it · fabio domenici, gaio paradossi and federico bordi...
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Prof.FedericoBordi
DeptofPhysics
current research activities in
applied physics : a brief outline
FedericoBordi [email protected]@roma1.infn.it
5/24/16 Research in applied physics Pagina 101
A long history made short the natural heir of the tradition of the Institute of Physics where P. Blaserna, the first president of the Italian Physical Society, was appointed director in 1872 and in 1926 Enrico Fermi was called to hold the first Chair of Theoretical Physics
5/24/16 Research in applied physics Pagina 102
A long history made short the natural heir of the tradition of the Institute of Physics, where P. Blaserna, the first president of the Italian Physical Society, was appointed director in 1872 and in 1926 Enrico Fermi was called to hold the first Chair of Theoretical Physics
Today ... an intense research activity in all the major areas of Physics: Particle Physics, Physics of Matter, Astrophysics and
Cosmology, Theoretical Physics, Biophysics, Geophysics Mathematical and Statistical Physics,
and applied Physics : to Cultural Heritage, Medicine, Biotechnology, Material Science and Nanotechnology
hos.ngresearchfacili.esofthemajorItalianresearchins.tu.ons,theNa.onalIns.tuteofNuclearPhysics(INFN)andtheConsiglioNazionaledelleRicerche(CNR),appoximately300researchersareac+veinourdepartment,includingtheprofessorsattheSapienzaUniversity.
Grapheneflakesaspoten+al
electrodesforLi-basedba]eries
adsorbmuchmoreLithiumions(Li:C=1:2)thangraphite
(Li:C=1:6)Graphenesingle-sheetasdecouplinglayer
inducingincreasedmagne+canisotropyofanorganometallicmolecule(FePc)
J. Phys. Chem. Letters 6, 1690 (2015)
...justafewexamples
Nano Letters 14, 4901 (2014)
Nano-porousgraphene,a3Dformofgrapheneforchargeaccumula+on
Graphene-based materials for energy and technology
LOTUS lab. (interfaces and nanostructures) MariaGraziaBETTIandCarloMARIANI
hVp://server2.phys.uniroma1.it/gr/lotus/index.htm
5/24/16 Research in applied physics Pagina 104
... just a few examples
Radio-guided surgery with β-radiation
Applied Radiation Physics (ARP) Group RiccardoFACCINI
hVp://arpg-serv.ing2.uniroma1.it/arpg-site/
usuallylongrangeγ-emi]erareused->(140keV photon: 8 cm in tissues)
• Exposureofmedicalpersonnel• Backgroundfromsurrounding
(healthy)+ssues
5/24/16 Research in applied physics Pagina 105
... just a few examples
Radio-guided surgery with β-radiation
Applied Radiation Physics (ARP) Group RiccardoFACCINI
hVp://arpg-serv.ing2.uniroma1.it/arpg-site/
usingshortrangeβ-tracer->(1 MeV photon: 5 mm in tissues)
• Reduceddosetomedicalstaff• Reducedbackground• Smalleradministeredac<vity• moreCompactdetectorsSCIENTIFIC REPORTS 4, 4401 (2014)
5/24/16 Research in applied physics Pagina 106
... just a few examples
Radio-guided surgery with β-radiation
Applied Radiation Physics (ARP) Group RiccardoFACCINI
hVp://arpg-serv.ing2.uniroma1.it/arpg-site/
usingshortrangeβ-tracer->(1 MeV photon: 5 mm in tissues)
SCIENTIFIC REPORTS 4, 4401 (2014)
scin.lla.ngcrystal+lightsensor(SiPM)
...justafewexamples
Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics
PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO
hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html
acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples
...justafewexamples
Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics
PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO
hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html
acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples
SERSeffectbasedonthelocalizedplasmonresonanceinmetallicnanostructuresincreasestheintensityofRamanemissionofmoleculesclosetothenanopar+clesurfacebyseveralordersofmagnitude
...justafewexamples
Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics
PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO
hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html
acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples
goldnano-par+cles(AuNp)conjugatedwithfolicacid(FA)areusedtoSERS-revealFAreceptorsthatareover-expressedbytherapidlydividingcancercells(FAisrequiredinDNAsynthesisprocess)
...justafewexamples
Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics
PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO
hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html
acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples
healthyandcancercellscanbedis+nguishedbyusingthe(substratenormalized)integratedintensityofthenanovector-specificSERSband(1580cm-1),basedonthedifferentexpressionofFOLICACIDreceptors
BIOMATERIALS2016,submiVed
...justafewexamples
Complex NANO-particles for theranostics
PhOBiA lab. (Physics of Bio-Assemblies) FabioDOMENICI,GaioPARADOSSIandFedericoBORDI
hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html
selec+velytargetedthermoresponsivenanogels:atemperaturedrivenshrinkingreleasesthedrugcargo(DOXORUBICIN)
Biomacromolecules16,1753(2015) Phys.Chem.Chem.Phys.18,8378(2016)
doubleshelled(lipidandcrosslinkedpolymer)decafluoropentane(DFP)dropletsforenhancedultrasoundcontrast
...andmuchmore
NMR diffusion of water for diagnostics
NMR lab SilviaCAPUANIhVp://lab-g1.phys.uniroma1.it/
molecular dynamics of proteins