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• Definition

• Synthesis pathway

• Application

• Advantages

• Challenges

• Conclusion

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CONTENTS

• New biological fluorescence material

• Nanoparticle

• Size : close to Bohr radius 10 nm

• Shape : Spherical

• Material : fluorescent semiconductor nanocrystal

• Made up : Group 12 and 16 elements

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DEFINITION

http://Chemistry.about.com

https://www.photonics.com

• 2 pathways : liquid phase & organic phase

• Restriction in organic phase

– High temperature

– Complicated step

– High cost

– Poor stability

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SYNTHESIS PATHWAY

• Liquid phase synthesis (more convenient)

– Metal ions

– Modified reagents

– Tellurium (Te) source

– Sulfur (S) or Selenium (Se) source

– Auxiliary reagent

– Heat

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…cont

• Tumor diagnosis

– QD-IgG & Cy3-IgG

• Drug delivery

– Cancer therapy

• Drug screening

– Mark target molecule

08

APPLICATION

Hu M, Yan J, He Y. Ultrasensitive, multiplexed detection of

cancer biomarkers directly in serum by using a quantum

dot-based microfluidic protein hip. ACS

Nano,2010,4(1):488-494.

DNA degradation

Cancer cell

uv

Quantum dot

Drug molecule

Antibody09

• Good quantum effect

– Broad & consecutive excitation spectra

– Tunable size-dependant emission

– Strong resistance to photo bleaching capacity

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ADVANTAGES

• Biocompatibility– Water solubility

– High self producing rate of fluorescent dots

– Stability of colloidal particle

– Lower nonspecific adsorption

• Biological coupling– Unstable coupling after UV irradiation

• Biotoxicity– Aqueous environment release Cd ion

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CHALLENGES

• Many advantages

– Biochemistry

– Target molecule labeling

– Fluorescent probe

• High prospect to develop

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CONCLUSION