prodigiosin synthesis uv-induced colorless mutants of serratia marcescens
TRANSCRIPT
Prodigiosin Synthesis
UV-induced “Colorless” Mutants of Serratia marcescens
amino acids
a
c
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
The Normal Pathway to Prodigiosin
O
NH
NH
N
A
C
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
Serratia marcescens D1 (wild type)(DNA is not mutated for any of the genes)
a
c
B(g)
D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
Serratia marcescens D1 (wild type)(DNA is not mutated for any of the genes)
a
c
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
Serratia marcescens D1 (wild type)(DNA is not mutated for any of the genes)
amino acids
a
c
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
A
C
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
c D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
b(g)A
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
c D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
b(g)A
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
amino acids
a
c
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
Serratia marcescens ( )(DNA is mutated in enzyme y gene)
c D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
b(g)A
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
amino acids
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
Serratia marcescens ( )(DNA is mutated in enzyme y gene)
A
C
c D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
b(g)A
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
amino acids
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
Serratia marcescens ( )(DNA is mutated in enzyme y gene)
C
a B(g)
c D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
b(g)A
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
amino acids
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
Serratia marcescens ( )(DNA is mutated in enzyme y gene)
C
a B(g)
933 WCF
WCF
933
c D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
b(g)A
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
amino acids
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
Serratia marcescens ( )(DNA is mutated in enzyme y gene)
C
a B(g)
933 WCF
B(g)
Prodigiosin
B(g)
WCF
933
c D(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
b(g)A
Serratia marcescens ( )(DNA is mutated in enzyme x gene)
amino acids
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme z
Serratia marcescens ( )(DNA is mutated in enzyme y gene)
C
a B(g)
933 WCF
D(ws)
Prodigiosin
D(ws)
a
c
b(g)
d(ws)
Prodigiosinenzyme x
enzyme y
enzyme zamino acids
Serratia marcescens D1 (wild type)(DNA is not mutated for any of the genes)
D1 WCF
d(ws)
D1 933
Why is D1 (so capable!) such a poor donor to either mutant…
…compared to cross-feeding from either mutant?
933 WCF
933 WCF
D(ws)
B(g)
b(g)