Principles of Immunology

Tumor Immunology4/25/06

Word/Terms List AFP Benign Carcinoma CEA Leukemia Lymphoma Malignant Metastasis Neoplasm Oncogene Sarcoma Transformation TSTA

Tumor Immunology

Benign vs. malignant tumors

Types of neoplasms

Carcinomas Leukemias/lymphomas Sarcomas

Cell Transformation

Characteristics

Nutritional changes

Lack of contact inhibition

Immortality

Chemicals and Cancer

Mitogens

Mutagens

Carcinogens

Genes and Cancer

Oncogenes

Proto-oncogenes

Tumor-specific Transplantation Antigens

Origin of TSTAs

Point mutations Expressed by germ line cells Expressed by specific cell types Over expressed Post translation changes Viral oncogenes

Oncofetal Antigens

Alpha fetoprotein (AFP)

Carcinoembryonic antigen (CEA)

Tumors of the Immune System

Leukemias ALL AML CLL CML

Lymphomas

Tumors and Viruses

Hepatitis B

Human papilloma virus(HPV)

Epstein Barr Virus

Tumors and Evasion of the Immune System

Low immunogenicity

Modulation by antibodies

Tumor secreted suppressors

Immune Response to Tumors

Cells NK CTLs Macrophages

Cytokines Interferon TNF

Immunotherapy Against Tumors

ADCC

Toxin conjugation

Radionuclide conjugation