hosm@uc.edu

tracie@pinkribbongirls.org

Breast cancer: Windows of Susceptibility. NIH grant 1U01ES019480

our MISSION

PINK RIBBON GIRLS

Bisphenol A studies.......................1Current nutrition labels..................2

Coffee Talks..................................5

Crossword puzzle...........................6Carrot and Kale salad.....................9Nutrient dense food.....................10Yoga Pose......................................11Kids' page......................................12

BCERP Integration Meeting.........4

TO PREVENT the occurrence of BCa through RESEARCH and EDUCATION

TO ENCOURAGE and SUPPORT BCa survivors, friends and families.

Contacts

askdrmeiho@gmail.com

August 2013 Issue 33Breast Cancer

MYTHs,FACTs,CHOICEsand

COMMUNITY PARTNERS

INDEXRESEARCH PARTNERS

1

Bisphenol A (BPA) is an chemical found both in rural and urban environments. The endocrine disruptive effects of BPA have proven difficult to define experimentally because of the contamination and variability in all the items (cages, water, bedding, commercial chow, etc) which need to be controlled in order that dose response data can be obtained. It is a problem that has caused confusing results to emerge. A study by one member of the research team here was designed to assess the endocrine disruptive actions of dietary BPA exposure, while carefully controlling for known confounders. They acclimated parental mice of a known strain to well-defined diet containing BPA (0.03, 0.3, 3, 30, or 300 ppm) or an environmental estrogen (EE) at 0.0001, 0.001, and 0.01 ppm). The progeny (F1) of these mice were maintained through adulthood on the same diet as the parents. In F1 females, uterine weights were increased in all EE and the 30-ppm BPA-exposure groups indicating sensitivity and estrogen-like actions of BPA. BPA apparently did not affect parental reproductive function, nor the timing of puberty and some metabolic functions in their female offspring. F1 males showed modest changes in body weight, adiposity and glucose tolerance speculated to be beneficial? Overall, BPA was found to have modest, sex specific endocrine disruptive effects on a variety of end points which occurred below the established NOEL (no observed adverse effect level ) for humans. The dose response characteristics for many of the effects were nonmonotonic (sometimes increasing sometimes decrease) and not a predictable straight line.

ubiquitous

EDITED FROM : Kendig EL, et al, and Belcher SM. disruptive effects of dietary exposure to bisphenol A or 17α-ethinyl estradiol in CD1 mice. Int J Toxicol. 2012 Nov-Dec;31(6):537-50.

Estrogen-like

Bisphenol A studies

EE

BPA

images from the internet

RESEARCH PARTNERS

QUESTION: What is the difference between the current nutrition label for food and other

information about nutrient density?

ANSWER

2

It is all about the water. Water content of food is a very important nutrient (nuff said LOL, as we all know this. A summary article is ). An astounding 40 % of our daily water intake comes from food. This is an easy task if you eat a quarter of a watermelon somewhere during the day, but is quite difficult if you only eat barbeque-flavored corn chip snacks. The nutrition label to the left is derived from a website that I think has some pretty good information because it is easier to "swallow" than the gov website and there are other options for learning about health as well but believe their data to be based primarily on the .gov tables.

Corn chips are a mere 1.2 % water wtih 523 kcal (calories). Watermelon is 91.4% water and 30 kcal. The % of nutrients listed in the labels to the right underestimate the amount of nutrition in watemelon compared to the chips by about 17 times, in addition to the fact that all the wonderful phytochemicals are that much increased as well.

There is considerable information about foods of all kinds that is posted on the internet (but consensus on any recommended amount of phytonutrients to ingest is modest).

Your feedback on what you would like to know about the nutrient value of food and how you would want it presented is valuable. Please contact us with your suggestions (millermn(at)ucmail(dot)uc(dot)edu).

HERE

HERE

Corn chips BBq flavorWatermelon

The website Nutritionself data does have some interesting concepts and they do use the USDA database so this gives one some confidence in their assessments. At this moment in time, and though not ideal, it seems to be an OK resource.

I am not sure a solution has been found, but one is being worked on. In the meantime the best rule of thumb is: if it has been cooked, processed, baked, fried and packaged by big business, just leave it on the shelf and go to the fresh produce section, or your local farmer's market.

For those of you who are interested in seeing tables that the USDA has posted for water content, protein, fiber and nutrients in hundreds of different foods is a link to those.HERE

Using this websites database one can see that food varies in its make up considerably. The overall nutrient value for watermelon in the bottom left graph shows beter overall nutrition but slightly less complete balance of the essential amino acids. The corn in the corn chips provides a reasonably complete protein but less overall nutrition but carries considerable kcal and other undesirables.

Next month I will look at the USDA website with the unfortunate name (LOL) .

Food - A - Pedia

SOLUTION:

DEF: Calorie = kcal (when one mentions calorie, or Calorie it refers to kcal, not everyone is careful to use the capital C in front of calorie, thus denoting that it means kcal (or kilocalorie)

3

RESEARCH PARTNERS

National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute had their July Integration meeting (just after the long weekend) at NCI Shady Grove Campus,9609 Medical Center Drive,

Rockville, MD.

The purpose of the meeting was to create a venue for the BCERP RESEARCH and COMMUNITY PARTNETS to exchange information and

share ideas that advance the study and understanding of the relationship between breast cancer risk and environmental exposures.

Read a touching story of strength

and giving in the face of adversity HERE

COMMUNITY PARTNERS

Coffee Talk

Wheresoever you go, go with all your heart.

Pink Ribbon GirlsCoffee Talk for July 2013

4

Location:294 N. Main Street, Monroe, OHSaturday, 20 July 2013 10- 2:00 AM

Confucius (551 BC - 479 BC)

Bisphenol A is present in quite high quantities in thermal receipts. This was mentioned in a previous issue (get issue and make link) but is revisited here, with some additional information about bisphenol A.

CROSSWORD PUZZLESfor better health

BreastCancerRisk

Windows ofSusceptibility

UNIVERSITY OF

CincinnatiDept of Env Hlth

RESEARCH PARTNERS

5

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Word Clues

6

1. Thermal papers often require a special _______ to stabilize them,2. The coating changes into a _____ after it senses the application of heat,3. There are both ______ and environmental concerns over thermal papers,4. Adverse effects on adverse effects on the reproduction, development and metabolism of laboratory ________ have been linked to bisphenol a exposure,5. Water bottles and sometimes ____ bottles have been made with plastics with bisphenol a,6. Thermal receipts usually print _____ blue or red,7. Thermal receipts are I nexpensive and are often used in ____ registers,8. Ten hours a day touching receipts could produce exposure of 71 micrograms bisphenol A but that is still less than the ______ tolerable limit,9. Glucuronidation - one pathway of metabolic detoxication of bpa - is influenced by ingestion of other _____ such as carbamazepine nepxosin and salicylates,10. The surface of some the thermal paper is coated with a mixture of ___ and a matrix,11. The acronym for endocrine disrupting chemicals is ___,12. The mode of action of bisphenol A is commonly called _________ disruption,13. Thermal receipts are made of thin paper which has a ____ sensitive coating,14. Another product made from plastics using bisphenol A as a plasticizer is the ____ in beverage cans,15. Thermal receipts are also used by grocery ______,16. Presently set is a tolerable daily intake or ___ is about 3 mg,17. Recent news indicates that the formation of _____ may be affected by early exposure to bisphenol A,18. Bis in the word bisphenol a stands for ___ as in this many phenol groups,.

1. The phenol part of bisphenol A comes from the two ______ radicals on the side of each benzene ring,2. Some - that is NOT all- thermal papers are coated with _______-_,3. The matrix gets warm and melts releasing acid which causes the dye to ______ color,4. One product made from plastics using bisphenol a as a plasticizer is the compact ____,5. Thermal receipts are used by merchants such as ___ stations,6. Texas Instruments invented the thermal print ____ in 1965,7. Unfortunately the highest bisphenol A and phthalate exposure is also found in _______ the most susceptible population,8. A fingernail swiped across a receipt can produce enough heat to make a ____,9. Pacifiers can contain nitrosamines bisphenol A or __________,10. Plastics that are polycarbonate typically use bisphenol A as a ___________,11. Some legislation is beginning to surface such as the _____ Sales Slip Act,12. Holding a receipt for 5 _______ transfers approximately 0.5 micrograms of bisphenol A to dry skin,13. Without a coating the images fade from UV from _____ and from oils fat and grease,14. Holding a receipt for 5 seconds with ___ fingers transfers about 5 micrograms of bisphenol A,15. Bisphenol A has the propensity to be more damaging during _______ of developmental susceptibility,

Answers:

Links to more puzzles

7

Carrot Salad Ingredients

2 pounds peeled carrots

2 tablespoons coconut oil 2 cups finely chopped onion 2 tablespoons harissa (store-bought or homemade) 1 heaping tablespoon tomato powder 1 teaspoon cumin seed 1 teaspoon caraway seed 1 teaspoon sucanat or honey 2 tablespoons water 3 tablespoons white wine vinegar 3 tablespoons extra virgin olive oil 2 cups shredded kale leaves, stems removed Sea salt

Preparation

Cook cleaned carrots whole chunks, for about 20 min or until just softening. Sauté the onion in coconut oil until just brown. Toast the cumin and caraway seeds in a dry skillet until they begin to smell fragrant. Cool seeds then grind them. Rinse carrots with cold water, set them aside to cool. then slice them into bite-sized pieces.

Add the ground spices, harissa, tomato powder, sucanat and water to the onion mixture. Stir to blend and heat through

for about 3 minutes. Add more water if needed. Pour the spice and onion mixture over the carrots and toss until coated. Drizzle on the olive oil and vinegar. Toss again. Salt to taste.

Allow ingredients to come to temperature so the flavors can blend. Add the kale just before serving. Serve at room temperature or slightly warmer

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Traditional-foods.comEDIBLE BITS from FRESH BITES daily

Carrot Kale salad with Harissa

According to Wikipedia -- Harissa (Arabic) is a Tunisian hot chili sauce whose main ingredients are piri piri (type of chili pepper), serrano peppers and other hot chili peppers and spices and herbs such as garlic paste, coriander seed, red chili powder, caraway as well as some vegetable or olive oil. "the catsup of Tunesia"Make your own, or purchase in glass bottles (avoiding cans with plastic linings),.

According to Wikipedia -- Sucanat is "pure dried sugar cane juice" (unprocessed sugar).

nutrient denSe f d

nutrient S

@260 kcal100 grams= 1/2 burger only

1:260

i cal rS o

:1 30nutrient Svit C, K, ,fiber,

Mn, rheosmin (raspberry ketone)for weight reduction

phenols, anthocyanins,antioxidants,

anti-inflammatory phytonutrients

i cal rS o

half of calories from fat,minerals Fe, Ca,

550 mg Na, 95 mg cholesterol

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most data derived from:http://www.ars.usda.gov/is/ar/archive/jun02/lyco0602.htm

52

nutrient dense

calorie dense

RELEASE STRESS

REDUCE CANCER RISK

GAIN STRENGTH

SUKHASANAeasy pose, or sitting pose

http://www.yogajournal.com/poses/2481

This post has text edited from the above link.

Sukasana is a simple and comfortable pose and doesn't require that your legs be close to the trunk of your body or tucked closely under your right and left legs.

Sitting on a soft support, with legs outstretched, begin by crossing your legs and placing each foot close to the opposite knee. Tuck your legs in toward the trunk of your body.

The outer edge of your feet should rest on the floor and you arches beneath the opposite shin. You will create a

triangle with two sides formed by the thighs and the third side your shins.

Press your hands against the floor at upir sodes. lift your behind slightly off the floor for a few breaths

then slowly lower yourself lightly back to the floor.

Lay your hands either in your lap, palms up, or on your respective knees with your palms down. Lengthen torso stretching up, draw your shoulder blades back without arching your lower back.

You can sit in this position for any number of breaths, but exchange crossed

positions of the legs at equal time intervals. days, do the opposite.

watch their video HERE.

FacebookWindows of Susceptibility

TubeYou

http://www.webmd.com/cancer/features/seven-easy-to-find-foods-that-may-help-fight-cancer

KDS

PAGE

Ifill in the crossword puzzle with the correct words

KIDS' Crossword Puzzle Cancer Fighting Foods

1. When considering what meat to eat think of _____ colors such as poultry and fish,2. Scientists know more about what not to eat like processed ____,3. Scientists heave learned that soda ___ is not a healthful way to get your calories or water,4. When considering vegetables to eat think of ____ colors which generally indicate more anti-cancer properties,5. Phytochemicals is the long word which describes the benefits of _____ as food,.

1. Excellent foods for reducing cancer risk are ___ fat and ___ calorie,2. Some foods do show the ability to reduce the risk of ______,3. Fruits with darker color like red and purple ______ and pomegranate have anticancer benefits,4. Huge helpings of ___ meat are definitely associated with more cancer,5. Four powerhouse vegetables are broccoli cauliflower cabbage and ____,

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