prevantative heartworm products in dogs & cats
TRANSCRIPT
PREVENTATIVE HEARTWORM PRODUCTS IN DOGS & CATS Kathy Chow
PharmD Candidate 2014
Western University of Health Sciences
Veterinary Specialty Hospital
November 6, 2013
OUTLINE
Prevalence Cycle of heartworm Location Clinical signs Diagnosis Heartworm in cats Heartworm preventative products MDR1 Gene mutation
HOW PREVALENT IS HEARTWORM DISEASE?
www.veterinarypracticenews.com
CYCLE OF HEARTWORM
HOW DOES HEARTWORM CAUSE DAMAGE IN THE HEART?
CLINICAL SIGNS IN DOGS?
History Physical Exam Clinical Signs
MildAsymptomatic or cough
Moderate Cough, exercise intolerance, abnormal lung sounds
CLINICAL SIGNS IN DOGS?
Severe Cough, exercise intolerance, dyspnea, abnormal heart and lung sounds, enlarged liver (hepatomegaly), syncope (temporary loss of consciousness from reduced blood flow to the brain, ascites (fluid accumulation in the abdominal cavity), death
Caval Syndrome Sudden onset of severe lethargy and weakness accompanied by hemoglobinuria (high hemoglobin)
DIAGNOSIS OF HEARTWORM DISEASE
ELISA Preferred method
Microfilaria Testing Radiography ECHO ECG
CATS AND HEARTWORM
Prevalencetypically 5% to 20% of that in dogs
Life cycle Shorter (2-3 years)
Clinical Signs Diagnostic
ECHO
HEARTWORM PREVENTATIVE PRODUCTS
Product;Species;Rx/OTC
Active Ingredients; route of administration
Prevent Heart worm
Hookworm
Roundworm
Whipworm
Tapeworm
Fleas
Flea Eggs
Youngest age to start
How often
Iverhart Plus
For dogsRx
Ivermectin;Pyrantel PamoateOral
X X X >6 weeks and no weight requirements
Monthly
Heartgard Plus
For dogsRx
Ivermectin;Pyrantel PamoateOral
X X X >6 weeks and no weight requirements;
Monthly
Product;Species;Rx/OTC
Active Ingredients; route of administration
Prevent Heart worm
Hookworm
Roundworm
Whipworm
Tapeworm
Fleas
Flea Eggs
Youngest age to start
How often
Heartgard
For catsRx
IvermectinOral
X X >6 weeks and no weight requirements
Monthly
Iverhart MaxFor DogsRx
Ivermectin;Pyrantel Pamoate; PraziquantelOral
X X X X >8 weeks and at least 6lbs
Monthly
HEARTWORM PREVENTATIVE PRODUCTS
HEARTWORM PREVENTATIVE PRODUCTS
Product;Species;Rx/OTC
Active Ingredients; route of administration
Prevent Heart worm
Hookworm
Roundworm
Whipworm
Tapeworm
Fleas
Flea Eggs
Youngest age to start
How often
Sentinel
For DogsRx
Milbemycin Oxime;Lufenuron
Oral
X X X X X >4 weeks and at least 2 lbs
Monthly
Advantage MultiFor dogsRx
Moxidectin; Imidacloprid
Topical
X X X X X X 7 weeks of age or older and weighing at least 3 lbs
Monthly
HEARTWORM PREVENTATIVE PRODUCTS
Product;Species;Rx/OTC
Active Ingredients; route of administration
Prevent Heart worm
Hookworm
Roundworm
Whipworm
Tapeworm
Fleas
Flea Eggs
Youngest age to start
How often
Advantage MultiFor catsRx
Imidacloprid;MoxidectinTopical
X X X X X 9 weeks of age or older and weighing at least 2 lbs
Monthly
RevolutionFor DogsRx
SelemectinTopical
X X X 6 weeks of age or older and no weight requirement
Monthly
Product;Species;Rx/OTC
Active Ingredients; route of administration
Prevent Heart worm
Hookworm
Roundworm
Whipworm
Tapeworm
Fleas
Flea Eggs
Youngest age to start
How often
Revolution For CatsRx
SelemectinTopical
X X X X X 8 weeks of age or older and no weight requirement
Monthly
TrifexisFor DogsRx
Milbemycin Oxime; Spinosad
Oral
X X X X X 8 weeks of age and older and weighing at least 5 lbs
Monthly
HEARTWORM PREVENTATIVE PRODUCTS
HEARTWORM PREVENTATIVE PRODUCTS
Product;Species;Rx/OTC
Active Ingredients; route of administration
Prevent Heart worm
Hookworm
Roundworm
Whipworm
Tapeworm
Fleas
Flea Eggs
Youngest age to start
How often
ProHeart 6For DogsRx
MoxidectinSQ Injection
X X 6 months to 7 yo
Every 6 months
CAUTION IN CERTAIN BREEDS
MDR1 Gene Mutation Australian Shepherd Australian Shepherd Mini Border Collie Collie English Shepherd German Shepherd McNab Sheepdog Old English Sheepdog Shetland Sheepdog Mix breeds with any of the above
QUESTIONS?
REFERENCES Heartworm Society. Current Canine Guidelines.
http://www.heartwormsociety.org/veterinary-resources/canine-guidelines.html. Accessed November 3, 2013.
FDA. Prevent Heartworm in Pets Year-round. http://www.fda.gov/ForConsumers/ConsumerUpdates. Accessed November 2, 2013.
Canine and Feline Dirofilariasis. www.vetlearn.com. Accessed November 1, 2013
Canine and Feline Dirofilariasis, life cycle pathophysiology, and diagnosis. www.vetlearn.com. Accessed November 1, 2013.
Canine and Feline Dirofilariasis: Prophylaxis,Treatment, and Complications of Treatment. www.vetlearn.com. Accessed November 1, 2013. Merck Veterinary Manual. Macrolytic Lactones.
http://www.merckmanuals.com/vet/pharmacology/anthelmintics/macrocyclic_lactones.html. Accessed November 4, 2013.
HeartGard Plus dogs and cats. Package insert. Accessed November 4, 2013. Sentinel Package Insert. http://sentinelpet.com Accessed November 4, 2013