Wiringless Implantable Stretchable Electronics

WISE vison

Fast market entry with Cortical Grids.

Market Breakthrough with Foldable SCS paddles.

We will revolutionize

leads manufacturing

First to produce Neuro-leads: highly conformable, completely stretchable, minimally invasive.

The Neuro-leads Scenario

Neuromodulation therapies:

Chronic pain (SCS)

Parkinson’s disease

Dystonia

Epilepsy

Depression

and many others …

Neuromonitoring Electrodes(iEEG)

NeurostimulationLeads (SCS, DBS)

Acute application:

Intra-Operative Neuro-Monitoring (IONM)

Identification of epileptogenic zones

Today Tomorrow

The Neuromodulation Market

Revenue data from Corporate Annual Reports (2005-2016)

• Neuromodulation Rev. (2016): $3.4B

• 15% of Revenues come from Leads

Constant growth by

~10%

The limits of current leads technology

are major roadblock on the way to

new therapies.

Current Market Problems

!

Neuromodulation LeadsNeuromonitoring Electrodes

INVASIVE

MIGRATION

BREAKAGE

LIMITED COMPLEXITY

HIGH PROD. COSTS

Bulky

Poorly conformable

Poorly stretchable

Low resolution

Hand assembled

Arbitrarily thin

Highly conformable

Highly stretchable

High resolution

Automation

LOW INVASIVITY

NO MIGRATION

NO BREAKAGE

UNLIMITED COMPLEXITY

LOWER PROD. COSTS

Neuromonitoring Electrodes Neuromodulation Leads

The WISE Solution: Next-generation leads

Neuro2World Connection

Soft tissue Hard electronic devices

Mechanical

mismatch

Hard metal leads

Conductiveelastomer

Device

Young’s Modulus (Pa)

The WISE technology

Stretchable

polymer

Supersonic

cluster beam

source

Conductive

nanoparticles (Pt, Ir)

Unrivaled stretchability

Arbitrarily soft & thin substrate

Biocompatible (ISO 10993-1:2009 Tests)

Easy manufacturing Conductive stretchable

nanocomposite

PCT/EP2011/054903

Easy Manufacturing

Arbitrarily soft & thin substrate (cold technology)

No Engineering Limitations

Any shape

Any size (from m to cm)

200 m4 mm

Any polymer

Polyurethanes

PMMAsSilicones

Robust Interconnection to standard electronics

wire

Robust interconnection

High risk of breakage

Need for wiring

Patent: PCT Nr. PCT/IB2017/053056

Cortical Grids: Overview

Intra-operative or Acute: max 29 days

Monitoring/mapping the cortical surface during brain surgery (IOM) or before the surgical treatment of Epilepsy (ECoG)

Single-use

Cortical grids are used for the recording, monitoring and stimulation of electrical signal on the surface level of the brain.

WISE’s Cortical Grids

Cortical Grids: WISE vs. Commercial

COMMERCIAL

Neuromodulation Leads: SCS Paddles

The first “Foldable SCS Paddle lead”

An SCS lead with all the advantages of a

Paddle lead

implanted byminimally invasive surgery

as a Percutaneous lead

SCS leads: Paddle vs. Percutaneous

PercutaneousPaddles

Two types of Leads are used for SCS:

Better stim. (directional)

Invasive/Costly insertion

Precise stim. spot (grid)

Complex removal

Worse stim. (non directional)

Easy/Cheap insertion

Less Precise stim. spot

Easier removal

Surgically placed Implanted through a needle

WISE’s Foldable SCS Paddle lead

This will change the

SCS paradigm

Requires WISE’s technology

WISE’s Foldable SCS Paddle lead

WISE’s Foldable SCS Paddle lead

Foldable in less than 4 mm

Product in development

Patenting & kickoff

WISE’s Roadmap

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

Angel round

Agite!2011

Technology Consolidation

Patenting & kickoff

WISE’s Roadmap

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

Angel round

Seed round

2012

250,000€ Investment

Prototyping & Animal testing

Technology Consolidation

Patenting & kickoff

WISE’s Roadmap

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

Angel round

Seed round

Seed+ round

€1M

2013

Prototyping & Animal testing

Technology Consolidation

Patenting & kickoff

WISE’s Roadmap

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

Angel round

Seed round

VC series A

€3M

Seed+ round

€1M

2015

CE mark / Market

Cortical Grids

Engineering,

Regulatory &

Clinical Trials

Prototyping & Animal testing

Technology Consolidation

Patenting & kickoff

Foldable Paddle

Engineering,

Preclinical &

Clinical Trials

CE mark / Market

WISE’s Roadmap

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

Angel round

Seed round

VC series B

€6.5M

VC series A

€3M

Seed+ round

€1M

CE mark / Market

Cortical Grids

Engineering,

Regulatory &

Clinical Trials

Tot. €11M

WISE Factory

• 1000 m2 facility• Offices, Labs and Production• 120 m2 of ISO 7 cleanrooms

Production

R&D

Offices

120 m2 ISO7 Cleanroom

R&D Lab

Production Lab

Offices

WISE’s Team