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8/3/2019 Presentation Micro Bio

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Herpetic Keratitis

Other names :

viral conjunctivitis

acute hemorrhagic conjunctivitis (AHC)

herpes conjunctivitis


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It is a self- limiting infection ofthe eyelids, conjunctiva andcornea due to viral invasion.

It often results in deep ulcersand may be one of the mostcommon cause of blindness inthe United States. It usually lastsfor 1-3 weeks.

Herpetic Keratitis


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Once herpes simplex is present in the eye, it

typically infects the eyelids, conjunctiva (thethin, filmy, mucous membrane that coversthe inside of the eyelids and the white partof the eye) and cornea (the clear, frontwindow of the eye).

It may also infect the inside of the eye;however, this is much less common.

It is acquired via person-to-person contactwith infected eye secretions.

Herpetic Keratitis


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The Human Eye


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The Causative Agent

Herpes simplex type I


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HSV I

General Characteristics:

*Spherical,

*Measures 120-200nm

diameter

*Double stranded DNA withprotein coat havingicosahedral symmetry.

*Enveloped neucleocapsid.


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Symptoms of Herpetic keratitis

Corneal inflammation

Red eye

Eye irritation

Reduced visual acuity Eye pain

Eye tearing

Light sensitivity
http://www.rightdiagnosis.com/sym/corneal_inflammation.htmhttp://www.rightdiagnosis.com/sym/red_eye.htmhttp://www.rightdiagnosis.com/sym/eye_irritation.htmhttp://www.rightdiagnosis.com/sym/vision_loss.htmhttp://www.rightdiagnosis.com/sym/eye_pain.htmhttp://www.rightdiagnosis.com/sym/photophobia.htmhttp://www.rightdiagnosis.com/sym/photophobia.htmhttp://www.rightdiagnosis.com/sym/eye_pain.htmhttp://www.rightdiagnosis.com/sym/vision_loss.htmhttp://www.rightdiagnosis.com/sym/eye_irritation.htmhttp://www.rightdiagnosis.com/sym/red_eye.htmhttp://www.rightdiagnosis.com/sym/corneal_inflammation.htm


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Prevention and Control:

Personal hygiene;

drainage precautions;

strict asepsis in eye clinics


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The list of treatments mentioned invarious sources forHerpetickeratitis includes the following list.Always seek professional medical

advice about any treatment orchange in treatment plans.

Treatment of HSV Infections

1-2% trifluridine1% iododeoxyuridine

3% vidarabine
http://www.rightdiagnosis.com/h/herpetic_keratitis/intro.htmhttp://www.rightdiagnosis.com/h/herpetic_keratitis/intro.htmhttp://www.rightdiagnosis.com/h/herpetic_keratitis/intro.htmhttp://www.rightdiagnosis.com/h/herpetic_keratitis/intro.htm


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Herpetic Keratitis


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Acanthamoeba keratitis


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Acanthamoeba

Keratitis


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Acanthamoeba keratitis: Infection of the eye

with a microscopic, free-living ameba(Acanthamoeba) that isreadily found in theenvironment- soil, air and water. Infectionmost often occurs through exposure to

contaminated waterwhilewearing contactlensese.g. swimming or showering in infectedwaters.

It is acquired by swimming in stagnantswimming pools; wearing of contact lensesovernight and while swimming.

Acanthamoeba Keratitis


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It is an infection characterized by the invasion ofa trophozoite into the eyes which on early stageof infection may consist of only mild a mildinflammation but later stages may result insevere pain and cause eye damage and may

complicate to blindness.

Acanthamoeba keratitis is a rare diseasewhere amoebae invade the corneaof the eye.

Acanthamoeba Keratitis
http://en.wikipedia.org/wiki/Rare_diseasehttp://en.wikipedia.org/wiki/Amoebaehttp://en.wikipedia.org/wiki/Corneahttp://en.wikipedia.org/wiki/Human_eyehttp://en.wikipedia.org/wiki/Human_eyehttp://en.wikipedia.org/wiki/Corneahttp://en.wikipedia.org/wiki/Amoebaehttp://en.wikipedia.org/wiki/Rare_disease


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Causative agent:

Acanthamoeba spp.

Acanthamoeba KeratitisAcanthamoeba

Phase contrast micrograph of anAcanthamoebapolyphaga cyst.

Scientific classification

Domain: Eukaryota

Kingdom: Amoebozoa

Genus: Acanthamoeba
http://en.wikipedia.org/wiki/File:Acanthamoeba_polyphaga_cyst.jpghttp://en.wikipedia.org/wiki/Biological_classificationhttp://en.wikipedia.org/wiki/Eukaryotahttp://en.wikipedia.org/wiki/Amoebozoahttp://en.wikipedia.org/wiki/File:Acanthamoeba_polyphaga_cyst.jpghttp://en.wikipedia.org/wiki/Amoebozoahttp://en.wikipedia.org/wiki/Eukaryotahttp://en.wikipedia.org/wiki/Biological_classification


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Inside the human body

Acanthamoeba

Keratitis


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General Characteristics:

Small, free living amoeba found in stagnant

fresh water, hot tubs, tap water and soil;

Has two developmental stages: trophozoite(Active, motile stage); cyst (Dormant, inactive,nonmotile stage)

Infective stage: Trophozoite

Reproduce by binary fission; encystationswhen environment becomes adverse.


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Life Cycle of Acanthamoeba

Si d S


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Vision impairment

Red eyes Light sensitivity

Severe eye pain

Eyelid swelling Watery eyes

Blurred vision

Sensation of something in eye Excessive tearing

Signs and Symptoms

P ti d C t l
http://www.rightdiagnosis.com/sym/impaired_vision.htmhttp://www.rightdiagnosis.com/sym/red_eye.htmhttp://www.rightdiagnosis.com/sym/photophobia.htmhttp://www.rightdiagnosis.com/sym/eye_pain.htmhttp://www.rightdiagnosis.com/sym/eyelid_swelling.htmhttp://www.rightdiagnosis.com/sym/watery_eye.htmhttp://www.rightdiagnosis.com/sym/blurred_vision.htmhttp://www.rightdiagnosis.com/sym/tear_symptoms.htmhttp://www.rightdiagnosis.com/sym/tear_symptoms.htmhttp://www.rightdiagnosis.com/sym/blurred_vision.htmhttp://www.rightdiagnosis.com/sym/watery_eye.htmhttp://www.rightdiagnosis.com/sym/eyelid_swelling.htmhttp://www.rightdiagnosis.com/sym/eye_pain.htmhttp://www.rightdiagnosis.com/sym/photophobia.htmhttp://www.rightdiagnosis.com/sym/red_eye.htmhttp://www.rightdiagnosis.com/sym/impaired_vision.htm


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Avoid swimming in stagnant swimmingpools

Use pre-heated tap water as facial wash

Avoid use of home-made saline solutions

Prevention and Control:

T t t


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Treatment

Topical application to affected eye ofpropamidine isethionate or miconazole

Corneal transplant

Eye removal surgery


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