T D CHUGHEmeritus Professor (NAMS),Sr. ConsultantBLK Memorial HospitalNew Delhi

1

“ Wrestling with Black Bear”

Torii Kiyomasu

(active 1696-1722)

“For the world does not yet censureThose who tread the path of Dreams”

Ono no Komachi

History of Influenza

“I had a little bird

Its name was Enza

I opened the window

And in-flu-enza”

• Structure of virus

• Seasonal Flu

• Mode of spread, definition of close contact

• Suspected, Probable, Confirmed cases

Present Status of Pandemic, 2009

• USA (August 6, 2009, 11AM ET)

– Reporting States: 50

– Hospitalized Cases: 6,506

– Deaths: 436

• India (August 12, 2009)

– Total Confirmed cases:1079

– Deaths: 14 (Pune: 7)

Biology of the Disease

• Incubation period

• Infectivity of virus

• Susceptibility to disinfectants

• Prevention: Chemo/immuno-prophylaxis

Laboratory Diagnosis

• Throat, nasal, naso-pharyngeal swabs

• Antigen Detection

• RT-PCR

• Viral Culture

• Antibody detection

Infection Control Measures

TAMIFLU• Oral, age, early, dose

• Neurological effects

• - 54% children

• Resistance

• - 0.33% adults, 4% children, 1.26 % overall

• - OPD: 0.5 % adults, 5.5% children

• - Hospitalized 18% children

• July 22,2009: 5 resistant

Future?

“ Life Must Go On”