THINGS YOU MAYNOT KNOW

ABOUT ACCIDENTAL OPIOID OVERDOSE

DRUG POISONING has now surpassed AUTOMOBILECOLLISIONS as the leadingcause of accidental death in the US, driven largely by prescription opioids2

Rx Rx

DEATH RATE

0

15

10

5

20

2000 2005 2010

Dea

ths

per

100,

000

peop

le

Year

238M PRESCRIPTIONS for opioid medications were �lled in 2011, up from 1 82M in 20011

OF OPIOID OVERDOSE DEATHS occur in medical users4

In 2010, there were

more than 13,000 of whichwere unintentional3

DEATHS CAUSED BYOPIOID OVERDOSE,16,651

60%

THAT’S ONE PERSON

EVERY 36 MINUTES

4

UP TO

1. Manchikanti L, Helm S 2nd, Fellows B, et al. Opioid epidemic in the United States. Pain Physician. 2012;15(3 Suppl):ES9–ES38. 2. National Center for Health Statistics. NCHS data on drug poisoning deaths. http://cdc.gov/nchs/data/factsheets/factsheet_drug_poisoning.pdf. Accessed May 16, 2014. 3. Centers for Disease Control and Prevention. Opioid-related deaths continue to increase. http://media.jsonline.com/images/OPIOIDS20GFIX.jpg. Accessed May 16, 2014. 4. Centers for Disease Control and Prevention.CDC grand rounds: prescription drug overdoses—a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61:10–13. 5. Centers for Disease Control and Prevention. Policy Impact: Prescription Painkiller Overdose. November 2011.6. Boyer EW. Management of opioid analgesic overdose. N Engl J Med. 2012;367(2):146–155.7. Leavitt, SB. Intranasal naloxone for at-home opioid rescue. Pract Pain Manag. www.practicalpainmanagement.com/treatments/pharmacological/opioids

/intranasal-naloxone-home-opioid-rescue. Accessed May 16, 2014. 8. Substance Abuse and Mental Health Services Administration. Opioid overdose toolkit: information for prescribers. http://store.samhsa.gov/product/Opioid-Overdose

Prevention-Toolkit/SMA13–4742. Accessed May 16, 2014.

©2014 kaleo, Inc. All r ights reserved. PP-EVZ-US-0109 May 2014

Opioid medications have a relatively narrowtherapeutic window, meaning that even small changes

– such as a single extra dose or the addition of a small amount of alcohol –

CAN CAUSE A POTENTIALLY FATAL OVERDOSE

In the event of an opioid overdose, seek emergency medical attention

Taking certainmedications in combination

with an opioid

Having history of respiratory conditions

(such as asthma, COPD or sleep apnea)

High dosageof opioids

Some risk factors include7:

Very slow orabsent breathing

Loss of consciousness

Extremely small pupils

Some signs include8:

6

475,000EMERGENCYDEPARTMENT VISITSin 2009 were due to the misuseand abuse of prescription opioids5 0

250K

500K

2004 2009