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Prenatal Sono graphicEvaluation of Short-limbed Dwarfism:An AlgorithmicApproach1Beverly A. Spirt, MD
Michael Ol4hant, MD
Ronald H. Gottlieb, MD2
Lawrence P. Gordon, MD
Prenatal sonographic evaluation of short-limbed dwarfism is initiatedwhen a significantly shortened femur is found or by referral of a pa-tient with a family history of skeletal dysplasia. If a short femur is
demonstrated, all the long bones are measured and evaluated for bow-ing, fractures, and mineralization. The bone dysplasia is categorized
according to whether it is mesomelic, rhizomelic, or micromelic and
whether bowing or fractures are present. The fetal spine, head, tho-rax, hands, and feet are carefully evaluated to differentiate the type of
bone dysplasia and to determine whether it is lethal. Serial examina-tions may be necessary. This approach will provide sufficient infor-mation to counsel the family, manage the pregnancy, and direct thepostnatal evaluation.
U INTRODUCTION
Skeletal dysplasias occur in approximately 0.024% of births (1). A prenatal sono-
graphic evaluation for a short-limbed dwarf may be initiated because of the mci-
dental finding of a shortened or bowed extremity or as a result of a referral be-cause of a family history of skeletal dysplasia. It is essential to remember that thedefinitive diagnosis of bone dysplasia is made postnatably based on clinical and ra-
diographic criteria. The purposes of prenatal detection are to counsel the family,
manage the pregnancy, and direct the appropriate postnatal radiobogic evaluation.We present an organized approach to the detection and evaluation of bone dyspla-
sias in utero.
Index terms: Bones, osteochondrod�’splasias, 40. 1 5 1 , 40. 1 52 #{149}Fetus, abnormalities, 856.87 1 , 856.873 #{149}Fetus, US
studies, 856. 1 298 #{149}Pregnancy, US studies, 856.1298
RadloGraphics 1990; 10:217-236
i From the Departments ofRadiology (B.A.S., R.H.G.) and Pathology (L.P.G.), SUN�5’ Health Science Center, 750 6 Ad-
ams St. Syracuse, NY 1 32 1 0 and the I)epartments of Medical Imaging (M .0. ) and Pathology (L. PG . ). Crouse Irving
Memorial Hospital, Syracuse. NY. From the 1988 RSNA annual meeting. Receivedjanuary 31 , 1989: revision request-
ed April 20 and receivedjune 30; accepted November 1 5. Address reprint requests to B.A.S.
2 Current address: Department of Radiology. Wilson Memorial Hospital, Johnson City, NY.
C RSNA. 1990
217
Prenatal evaluation for short-limbed dwarf initiated
because of
positive family history
normal femur length
seriai measurements beyond 27 weeks
io riek oui heterozygous achondropiasa
Nabnormal femur length
(<95th %ile)
measure all long bonesevaluate bones for bowing,
fracture, mineralizationmeasure cardiothoracic (C 1)
ratio; thoracic circumferenceevaluate spine: mineralization,
curvatureevaluate hands, feet: polydactyly,
Hitchhiker thumb, clubbingevaluate head: shape; hydro-
cephalus
Classification of short�limbed dwarfs by bone
measurements
_/1\_Mesomelic Rhizomelic Micromelic
Langer SyndromeNrevergeit SRe’nhardl SRob�riow SWerner S
Heterozygousachoridroplasra
chOndrOdyS�aasapunclala
I I IMiLd Mild. Bowed #{149}1e�reJeune Syndrome Osreogenesis mperiecia Thanaiophoric DwarfEihs-vancreveid S (Type iii) Homozygous achondropiasiaDrasirophrc Dwarf Campiomelic dwarf Achondrogenesis
Hypophosphaiasia
Osleogenesisimpertecta (Type ii)
Shod dbbed polydaoyiy
syndromes
Figure 3. Algorithm 2 for classification of short-limbed dwarfism on the basis of long-bone mea-surements. S = syndrome.
218 U RadioGrapbics U Spirt et a! Volume 10 Number 2
It is especially important to identify those
bone dysplasias that are lethal (listed in or-der of decreasing frequency [i -3]) : thanato-
phoric dysplasia; osteogenesis imperfecta,
type II; achondrogenesis, types I and II;Jeune syndrome (may be nonlethal) ; hypo-
phosphatasia (congenital lethal form) ; chon-
droectodermal dysplasia (usually nonlethal);
chondrodysplasia punctata, rhizomelic type;
camptomelic dysplasia; short-rib polydactyly
syndromes I, II, and III; and homozygous
achondroplasia.The gestational ages at which the different
skeletal dysplasias are seen vary; therefore,the diagnosis of an abnormality should not
be excluded if it is not visualized during a
single in utero examination. Often, serial ex-aminations are necessary (eg, for achondro-
plasia [4]) . The classification we present is
intended as a starting point and is based on
the present understanding of skeletal dyspla-sias. Although not all the abnormalities and
variants fit neatly into groups, the categories
are sufficiently broad to accommodate mostcases. All types are not illustrated, and someare not shown sonographically because of
their rarity.
U APPROACHThe diagnosis of short-limbed dwarfism
should be suspected when the femur length is
below the 95% confidence limits. To deter-
mine whether one is dealing with a general-
ized bone dysplasia, all long bones of the fe-
tus must be measured and evaluated for bow-ing, fractures, and mineralization (Fig 1).
The sonographic evaluation of minerabiza-tion is difficult. Useful signs of decreased
mineralization include an unusually promi-
nent falx (5) , absent or decreased visuabiza-
tion of the spine (6) , decreased bone echo-genicity, and nonuniform or weak acoustic
shadowing (7).The dysplasia can then be characterized
according to which limb segments are most
prominently involved and whether bowing is
Figure 1. Algorithm I for prenatal evaluation ofshort-limbed dwarfism.
the predominant feature (Figs 2 , 3) . Evalua-tion of the other parameters listed in algo-
rithm 1 aid in the differential diagnosis with-
in each classification (Figs 4-6).
A complete evaluation of the fetal head,spine, thorax, hands, and feet should be per-
formed (Fig i) . Examination of the thorax
should include measurement of the cardio-
thoracic ratio and thoracic circumference todifferentiate a cardiac from a pulmonary ab-
normality.
a. b. C.
d. e.
March 1990 Spirt et al U RadioGrapbics U 219
Figure 2. Drawings depict the skeletalcharacteristics of the three classificationsof short-limbed dwarfism as they are seenin the leg. (a) Normal leg. (b) In meso-melic dwarfism, there is disproportion-ate shortening of the tibia and fibula.(c) In rhizomelic dwarfism, there is dis-proportionate shortening of the femur.(d, e) In micromelic dwarfism, there isdisproportionate shortening of the entireleg. This classification is further subdi-vided into mild (d), mild and bowed,and severe (e).
Mesomelic: differential diagnosis, prognosis
normal C T ratio, thoracic circumference
normal spinenormal headno polydactyly
Syndromes as in Algorithm II:NONLETHAL
Rhizomelic: differential diagnosis, prognosis
has not been reported on
inutero ultrasound
Micromelic: differential diagnosis, prognosis
decreased horace circumferenceincreased C T ratio
normal spnemay have polydactyly
Micromelic: differential diagnosis, prognosis
mild, bowed
Camptomelic dwarf’LETHAL
Micromelic : differential diagnosis. prognosis
severe
increased C T ratio
decreased horace circumference
C-
220 U RadioGrapblcs U Spirt et al Volume 10 Number 2
‘If any of these parameters are abnormal, obtain serial
measurements and consider moving to another category.
Figure 4. Algorithm 3 for diagnosis of mesome-lic dwarfism. CT cardiothoracic.
stippled epiphyses
Chondrodysplasia punctata,
Rhizomelic formLETHAL
Heterozygous achondroplasia’
NONLETHAL
‘If initial measurements of femurare normal. do serial measurementsbeyond 27 weeks
Figure 5. Algorithm 4 for diagnosis of rhizome-licdwarfism. CT cardiothoracic.
normal C T ratio and thoraciccircumference
(hand and spine abnormalities
seen on postnatal radiographs
have risl been reported on in
utero utrasound I
mild
may have slightly decreased thoracic ratiomay have increased C T ratiomay have abnormal curvature of spineHitchhiker thumb. abnormal great toe
Jeune syndrome (ATD)’Ellis - Van Creveld”
Guarded Prognosis: _____________MAY BE LETHAL
. Evahiate fetal kidneys
Evaluate fetal heart
a.
Diastrophic dwarf
NONLETHAL(except for rare lethal form
associated with tracheal hypoplasial
normal mineralization, decreased mineralization, decreased mineralization.no fractures no fractures fractures
N\ IThanafophoric Dwarf Osteogenesis imperfectaHomozygous �ct�ondroptasia (Type It)(Achondro�enesis) (Hypophoaphatasla)
LETHAL \\\\ LETHAL
pof�actyly
AchondrogenesisHypophosphatasia
LETHAL
Short rib potydactyty syndrome
LETHAL
�normal cerveal spinefracturesnormal C T ratio increased C I ratio
decreased thoracic circumference
Osteogenesis imperfecta(Type Ill)
NONLETHAL
b.
‘ evaluate for abnormal scapula,disproportionate tibia\fibula
Figure 6. Algorithm 5 for diagnosis of mild (a),
mild and bowed (b), and severe (C) micromelicdwarfism. ATD = atrial septal defect, CT car-diothoracic.
U MESOMELIC DWARFISM
Mesomelic dwarfism (Fig 4) is characterized
by a shortening of the radius and ulna or tibia
and fibula (Fig 2b) . This sign is one of themajor characteristics of the Langer, Niever-
gelt, Reinhardt, Robinow, and Werner syn-
dromes. These syndromes are all hereditaryautosomal dominant conditions except for[anger syndrome, which is an autosomal re-cessive condition.
The mesomelic syndromes are not lethal,
and the definitive diagnosis is made postna-tally on the basis of clinical and radiographic
criteria. Patients with Robinow syndrome
may be mentally retarded; patients with the
80
60
Upper 99% Cl
40
20
9% Cl
0 -I.’ ________20 25 30 35 40 45 50 55
-���l’�”’\ �
�s,I .�:�:‘:
� #{149}i”��
,� ,‘,‘:‘:�‘60 65 70 75 80 85 90
Biparietal Diameter (mm)
i.e
C.
4w
Figure 7. Heterozygous achondroplasia. (a) Femur length (0) normal at 1 7 weeks gestational age.Growth curve flattened between 20 and 22 weeks. Cl = confidence limit. (Adapted from reference 4.)
(b) Sonogram obtained at 22 weeks shows short femur (length is below 95% confidence limits) . Bone ap-pears otherwise normal. (C) On xeroradiograph offetus, humeri appear slightly short. Although radio-graphic criteria are not apparent at this stage, diagnosis was confirmed by means of electron microscopy.(Fig 7b and 7c courtesy ofAbfred Kurtz, MD, ThomasJefferson University Hospital, Philadelphia.)
other syndromes should have normal intelli-gence.
U RHIZOMELIC DWARFISM
Rhizomelic dwarfism (Fig 5) is characterized
by shortening of the humerus or femur (Fig
2c) . Two conditions belong to this classifica-
tion: heterozygous achondropbasia and chon-
drodysplasia punctata, rhizomelic type.
Heterozygous Acbondroplasia.-This con-
dition is the most common nonlethal bone
dysplasia, with a prevalence of one in26,000 births (2) . The condition may be in-herited (autosomab dominant pattern) , or it
may arise due to new mutation of genes.
On in utero sonograms of a fetus with het-
erozygous achondroplasia, the proximal long
bones are shortened, have normal mineral-ization, and have no fractures. The cardio-
thoracic ratio is normal. Initially, the lengths
of the femurs are normal, but by 27 weeks
gestational age, the lengths are shorter than
the usual range (<95% confidence limit)
(Fig 7) . Therefore, one cannot exclude the
diagnosis of heterozygous achondroplasia
until after the third trimester.
On neonatal radiographs, the lumbar pedi-
des are shortened, and the normal progres-
sive widening of the lumbar interpedicubar
distance does not occur. Rhizomebic shorten-
ing of the bong bones is seen. The iliac bones
are flat and nonflared, with small sacrosciatic
100
March 1990 Spirt et a! U RadioGrapbics U 221
Figure 8. Chondrodysplasia punctata, rhizome-lic type. Neonatal radiograph shows large stippledepiphyses, most prominent in humeri and femurs.
222 U Ra4ioGrapbics U Spirt et a! Volume 10 Number 2
notches. The base of skull and foramen mag-
num are small, and the hands have a trident
shape.
Cbondrodysplasia Punctata.-The rhizo-melic type of this lethal condition is inherit-
ed in an autosomal recessive pattern.On neonatal radiographs, the vertebral
bodies are irregular, with coronal clefts. Rhi-
zomelic shortening, with metaphyseal splay.ing and stippled epiphyses, is seen in thebong bones (Fig 8) . Extracartilaginous stip-
pbing is seen as well.
Although, to our knowledge, antenatal di-
agnosis has not been reported, the findings
of hyperteborism and stippled epiphyses ac-
companying rhizomebic bone dyspbasia
would be suggestive of chondrodysplasia
punctata.
U MICROMELIC DWARFISM
Micromelic dwarfism may vary in severity,
the shape of the bone, and the degree of mm-
eralization. They may be categorized as mild,
mild and bowed, and severe.
. Mild Micromelic DwarfismThe algorithm for this classification is fea-
tured in Figure 6a. The differential diagnoses
include Jeune syndrome, Ellis-van Creveld
syndrome (or chondroectodermal dysplasia),
and diastrophic dwarfism.
Jeune Syndrome.-This often lethal syn-drome is also known as asphyxiating thoracic
dysplasia. It is a hereditary autosomal reces-
sive condition and cannot be distinguished
from Ellis-van Creveld syndrome in utero.
Associated renal disease may occur.
On in utero sonograms, the bong bones are
proportionately shortened. The thorax is
small, with a decreased circumference and
increased cardiothoracic ratio. Polydactyly is
occasionally seen.
On neonatal radiographs, the spine is nor-
mal. The extremities are shortened, with oc-
casionab polydactyby. The pelvis has a triden-
tate appearance, with small, flattened ilia,and the thorax is small in both anteroposteri-
or and transverse dimensions (Fig 9).
Ellis-van Creveld Syndrome-This heredi-
tary autosomab recessive condition is usually
not lethal. About 50% of the patients with
this syndrome have a cardiac anomaly (usual-
by atrial septal defect).
Figure 9. Jeune syndrome. Neonatal radiographshows small thorax, short limbs, and trident pci-vis (arrow). Note polydactyly of left hand.
March 1990 Spirt et al U Ra4ioGrapbics U 223
On in utero sonograms, the long bones areproportionately shortened. The thorax is
small, with a decreased thoracic circumfer-
ence and increased cardiothoracic ratio.
Congenital heart defects (usually atrial sep.
tab defect) and pobydactyly are frequently
seen.Radiographs of the neonate demonstrate a
normal spine and proportionately shortenedlong bones with frequent pobydactyly. A tn-
dent pelvis with small, flattened ilia is seen.The thorax appears small in both anteropos-tenor and transverse dimensions, and a cardi-
ac anomaly is commonly present.Ellis-van Creveld syndrome is difficult to
distinguish from Jeune syndrome, since poby-
dactyly, narrow thorax, and trident pelvis oc-
cur in both entities. Occasionally, a patient
with Ellis-van Creveld syndrome will havemesomelic shortening of the long bones.
However, the abnormal thorax enables theradiologist to distinguish this entity from
other mesomelic syndromes.
Diastropbic Dwarflsin-Infants with this
hereditary autosomal recessive conditionmay have a characteristic facial expression
and cauliflower ears. Normal intellectual de-
vebopment occurs, and the condition is usu-ally not lethal.
In uteno sonography demonstrates propor-tionately shortened long bones, with associ-ated hand and foot deformities (hitchhiker’s
thumb, clubfeet) (Figs 1 0, 1 1) . Joint con-
tractures and abnormal spinal curvature may
be seen.Neonatal radiography reveals moderately
flattened vertebral bodies. Progressive ky-phoscoliosis of the cervical, thoracic, or
lumbar spine occurs. The lumbar interpedi-cular spaces are narrow. Radiography alsoshows proportionate shortening of the long
bones, with flattened epiphyses and widened
metaphyses. The first metacarpal is hypoplas-
tic and oval (hitchhiker’s thumb); talipesequinovarus may be present (1 0, 1 1).
S Mild, Bowed Micromelic DwarfismThe algorithm for this classification is given
in Figure 6b. The differential diagnoses in-
dude camptomelic dysplasia and osteogene-
sis imperfecta, type III.
Camptomelic Dysplasia.-The inheritance
pattern for this condition is either sporadic
or autosomal recessive. The condition is usu-ally not lethal. When deaths occur, most are
due to respiratory insufficiency in the neona-tab period.
d.Figure 10. Diastrophic dwarfism. Sonograms obtained at 37 weeks gestational age show short femurs
(a) and abnormal thumb (arrowhead in b) . (C) Corresponding neonatal radiograph of hand shows hitch-hiker thumb and small, oval first metacarpal (arrow) . Note bone dysplasia and elbow dislocation.
(d) Lumbosacral lordosis (arrows) seen on sonogram is confirmed on neonatal lateral radiograph (e).
224 U RadioGrapbics U Spirt et a! Volume 10 Number 2
C. d.
March 1990 Spiil et a! U RadioGraphics U 225
Figure 11. Diastrophic dwarfism. (a) Graph of femoral and tibial measurements (in millimeters) ob-tamed from serial sonograms beginning at 1 5 weeks gestational age. Comparison of these measurementswith the usual ranges indicates the presence of micromelic shortening. (b, C) Scans obtained at 27 weeks
show short femur (cursors in b) and clubfoot (arrowheads in C) . Arrow = tibia. Visualization of the meta-
tarsal bones and tibia and fibula at right angles in the same coronal plane is diagnostic of clubfoot (8,9).(d) Neonatal anteroposterior radiograph shows oval first metacarpal (arrow) , mildly flattened vertebral
bodies, and hypoplastic cervical vertebrae. Kyphoscoliosis is not yet evident.
On in utero sonograms, femurs and tibiasare bowed and fibulas are short (Fig 12).
Thoracic circumference is decreased, and
scapulae are hypoplastic. Cleft palate may be
detected.Neonatal radiography reveals hypopbastic
vertebrae (especially in the lower cervical
area) and scapulae. Tracheal narrowing may
be present. Femurs are bowed. Tibias arebowed anteriorly, with an associated soft-tis-
sue dimple. Fibulas are short.
e f.Figure 12. Camptomelic dysplasia. (a, b) Sonograms obtained at 34 weeks gestational age show bowed
femur (arrows in a) and short fibula (arrowhead in b) . (c-e) Neonatal radiographs show angulation of dis-
tal tibias, hypoplastic scapulas (arrowheads in C) , and marked cervical lordosis. Note tracheal narrowing(arrow in d). (I) Pretibial dimple (arrow) is a classic clinical finding (cf arrow in e). (Figure 1 2a and 1 2bcourtesy of Gerald Segal, MD, Utica, NY.) (Reprinted, with permission, from reference 12.)
226 U RadioGraphics U Spirt et a! Volume 10 Number 2
a. b.
C. d.
March 1990 Spirt et a! U RadioGraphics U 227
Figure 13 Osteogenesis imperfecta, type III, progressive deforming type. (a, b) Sector scans obtained at27 weeks gestational age show short, thick, bowed left femur (arrow in a) and left tibia (arrowhead in b).Open arrow in b = foot. (C) Scan taken at 32 weeks shows short, bowed right femur (arrows) and bowedtibia (arrowheads) . Open arrow = foot. (d) Neonatal radiograph reveals the same findings in the lower cx-tremities. The mother was similarly affected. (Reprinted, with permission, from reference 1 2.)
Osteogenesis Imperfecta� Type 111.-This
nonlethal, progressively deforming disorderhas a heterogeneous inheritance pattern (ie,it can be autosomal dominant, autosomab re-
cessive, or sporadic).On in utero sonograms, the long bones are
short and bowed (Fig 1 3), with fractures.
However, the humeri may be almost nor-
mal in shape (1 3) . Acoustic shadowing ispresent. Thoracic size is within normallimits.
On neonatal radiographs, the vertebraeand pelvis are normal. Long bones are short,
bowed, and fractured. However, fracturesusually heal webb, in the shape of the bone.Humeri are usually less involved (13,14).
Rib fractures may be present.
Infants with type III osteogenesis imper-
fecta have normal sclerae. Joint hyperbaxity
is present in 50% of children with this disor-der (1 3). Progressive deformities of thelimbs occur during childhood. The spine be-
228 U RadioGrapbics U Spirt et a! Volume 10 Number 2
comes progressively abnormal during late
childhood or adolescence.
There are four major types of osteogenesis
imperfecta (1 3) . Types I and IV are autoso-mal dominant types: Type I is characterized
by blue sclerae, and type IV by normal
sclerae. Both are considered to be “tarda”
forms, being found after birth. (In type I
cases with fractures at birth, the fractures are
considered to have occurred during delivery
[1 3J.) Normal findings at in utero sonography
do not mean that the diagnoses of types I and
IV, or milder forms of type III, osteogenesisimperfecta should be excluded.
. Severe Micromelic DwarfismThe algorithm for this classification is pre-
sented in Figure 6c. The differential diag-
noses include thanatophoric dyspbasia; het-
erozygous achondroplasia; osteogenesis
imperfecta, type II; achondrogenesis; hypo-
phosphatasia, congenital lethal form; and
short-rib pobydactyly syndromes.
Thanatopboric Dysplasia.-This lethal
condition is the most common bone dyspla-
sia, with a prevalence of one in 6,400 (2) to
one in 16,700 (1) births. The inheritance
pattern is sporadic.
Distinguishing features on in utero sono-
grams include pobyhydramnios (7 1 % of
cases) , narrow thorax, macrocrania (includ-ing hydrocephabus), and cloverleaf skull de-
formity (Figs 1 4- 1 6) . Femurs may be
bowed. Major neonatal radiographic findingsinclude marked platyspondyly; short, broad,
bowed bong bones; small pelvis; narrow tho-
rax; macrocrania; and cloverleaf skull defor-mity.
Homozygous Acbondroplasia.-This rare
entity resembles thanatophoric dysplasia. It
is hereditary, with an autosomal dominant
pattern, and lethal.
Osteogenesis Imperfecta, Tjpe H (Perina-
ta,l Lethal Form).-This condition has ci-
ther an autosomab recessive or sporadic in-
heritance pattern (15).
In utero sonograms demonstrate fracturedlong bones and ribs, with minimal acoustic
shadowing from bones. Neonatal radiographs
reveal platyspondyby, spinal osteopenia, and
a poorly mineralized skull (Figs 17-19). Thelong bones have short thick shafts, general-
ized osteopenia, and multiple fractures.
Babies with type II osteogenesis imper-
fecta have blue scberae. Demise is usually
due to pulmonary hypoplasia.
Acbondrogenesis.-This autosomab reces-
sive condition may be subclassified into two
types. Both types are lethal. The radiobogic
findings of type 1 include poorly or nonossi-
fled spine and cabvaria; flared, fractured ribs;poorly ossified pelvis; absent sacrum; and ab-
sent pubis. In type 2 , there is variable ossifi-cation of the spine and skull, no rib frac-
tures, ossified iliac bones, and deficient sa-
crum and pubis (Figs 20, 21).
Hj�opbospbatasia (Congenital Letbal
Form).-Fetuses with this hereditary auto-
somal recessive condition have short, poorly
mineralized extremities; short, poorly ossi-
fled ribs; and poorly mineralized calvaria andspine on sonograms (Figs 22, 23).
On neonatal radiographs, the vertebrae arepoorly ossified, especially the neural arches.
No ossification of whole long bones is
present; irregular metaphyseal defects are
seen. Pelvic bones are small. Major portions
of the calvaria, base of the skull, and facial
bones are not ossified.
Sbort-Rib Polydactyly Syndromes.-Fetus-
es with this lethal, hereditary autosomab re-
cessive condition have a narrow thorax, short
ribs, and pobydactyby on sonograms. Major
neonatal radiographic findings include short,
horizontally oriented ribs and pobydactyly.
C. d.
Figure 14. Thanatophoric dysplasia. (a) Sonogram obtained at 26 weeks gestational age shows short fe-
mur (arrow) . (b) Another scan shows narrow thorax (black arrows) , macrocrania, and hydrocephalus(white arrow) . Photograph (C) and radiograph (d) of neonate show large head, narrow thorax, and severemicromelia. (Reprinted, with permission, from reference 1 2.)
March 1990 Spirt et a! U Ra4ioGrapbics U 229
Figure 15. Thanatophoric dysplasia. (a) Fetal
sonogram obtained at term shows short, non-
bowed femur. (b-e) Other scans reveal abnormal,lobular configuration of the caivaria (arrows in
, consistent with cloverleaf skull deformity.
This is distinguished from encephalocele by the
presence of calvaria around the entire brain. Alarge monoventricle (V) with a partial interhemi-spheric fissure (curved arrow in e) is seen, consis-tent with semilobar holoprosencephaly.
b. C.
d. e.
230 U RadioGrapbics U Spirt et a! Volume 10 Number 2
4*
_ . �;�5 on neonatal radiographs of the fetus in Figuredysplasia with cloverleaf skull (kleeblattsch#{227}del) deformity.
I, -i� � � � .;-�-� ,�v
1 5 confirm diagnosis of thanatophoric
.�t#{149}�
,“1iz_� . �
a. D.
March 1990 Spirt et a! U RadioGrapbics U 231
Figure 17. Osteogenesis imperfecta, type II.(a) Sonogram obtained at 1 8 weeks gestationalage shows short, angulated femur (cursors).Acoustic shadow is absent. (b) Cross-sectionalscan of the thorax shows fractured rib (arrows).
S = vertebral body. (C) Another scan shows un-usually bright falx (curved arrow) because of de-mineralization of skull (5).
Figure 18. Anteroposterior (a) and lateral (b) radiographs of same 1 8-week-old fetus as in Figure 17
show short, fractured, demineralized long bones and ribs, consistent with osteogenesis imperfecta, type II.Note demineralization of skull.
232 U RadioGrapbics U Spirt et a! Volume 10 Number 2
b. d.
Figure 19. Osteogenesis imperfecta, type II. (a) Sonogram obtained at 35 weeks gestational age showsshort, angulated humerus (cursors) with poor acoustic shadow. (b) Cross-sectional view of thorax showsabnormally increased cardiothoracic ratio (see cursors) . The thoracic circumference was decreased.(C) Scan of the fetal head taken at 30 weeks shows bright falx (arrow), a finding indicating poor mineral-ization of skull. (d) Findings on neonatal radiograph confirm the diagnosis.
March 1990 Spirt et a! U RadioGraphics U 233
a. b.
Figure 21. Neonatal photograph (a) and radiograph (b) of fetus in Figure 20 show severe micromelia.Spine is poorly mineralized, and sacrum and pubis are absent. Arrow femur.
234 U RadioGrapbics U Spirt et a! Volume 10 Number 2
Figure 20. Achondrogenesis, type II. (a, b) Son-ograms obtained at 33 weeks gestational age showvery short femur with poor acoustic shadow (cur-sors in a) and poorly visualized spine (arrow-heads in b), a finding indicating poor mineraliza-
iion. Arrow in b = nuchal cystic hygroma, H fe-tal head. Note lack of acoustic shadows fromspine. Compare b with C, a sonogram of a normalfetal spine at 25 weeks gestational age.
Figure 23. Neonatal radiographs of fetus in Fig-ure 22 show minimally ossified calvaria; thin,
and fibula. Arrows foot. (C) On sonogram ob-tamed at 22 weeks, the falx (arrow) is moreprominent than the calvaria, a finding indicating apoorly mineralized skull. (Courtesy of RichardGerle, MD, Syracuse, NY; reprinted, with permis-sion, from reference 12.)
short, poorly ossified long bones; and ribs with
widened, irregular ends. (Reprinted, with permis-sion, from reference 12.)
March 1990 Spirt et a! U RadioGrapbics U 235
236 U RadioGrapbics U Spirt et a! Volume 10 Number 2
U SUMMARYEvaluation of bone dysplasia is initiated by
the finding of a significantly shortened femur
or a referral of a pregnancy at risk. If a short
femur (length less than the 95% confidence
limit) is demonstrated, all long bones should
be measured and evaluated for bowing, frac-tures, and mineralization. In the case of sus-
pected heterozygous achondroplasia, serialmeasurements should be obtained up to at
least 27 weeks gestational age.
If a bone dysplasia is present, it should be
classified as mesomelic, rhizomebic, micro-
melic (mild or severe) , and bowed and/or
fractured. The fetal spine, head, thorax,
hands, and feet should be evaluated to aid in
the differential diagnosis.
It is important to determine whether the
fetus has a lethal or possibly lethal form of
short-limbed dwarfism. Although the final
diagnosis cannot be made until after birth,
the above evaluation will provide sufficient
information to counsel the family during the
pregnancy and to direct the postnatal evalua-
tion for definitive diagnosis.
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