preliminary work and proposed continuation: imaging of speech anatomy and behavior
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Preliminary Work and Proposed Continuation: Imaging of Speech Anatomy and Behavior. Mark Hasegawa-Johnson, ECE Department Thomas Conturo, Washington University Xuming He, Illinois David Kuehn, Illinois Zhi-Pei Liang, Illinois Jeff Marsh, Children's Hospital St. Louis - PowerPoint PPT PresentationTRANSCRIPT
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Preliminary Work and Proposed Preliminary Work and Proposed Continuation: Imaging of Speech Continuation: Imaging of Speech
Anatomy and BehaviorAnatomy and BehaviorMark Hasegawa-Johnson, ECE Department
Thomas Conturo, Washington UniversityXuming He, Illinois
David Kuehn, IllinoisZhi-Pei Liang, Illinois
Jeff Marsh, Children's Hospital St. LouisLynn Marty-Grames, Children's Hospital
Jerry Moon, IowaVictor Schepkin, Illinois
Reiner Wilhelms-Tricarico, MIT
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OutlineOutline
History: Normative Data
Future: Clinical Data
Difficult Imaging Problems and Possible Solutions
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Normative Data: Speech PostureNormative Data: Speech PostureHasegawa-Johnson et al., Hasegawa-Johnson et al., http://www.ifp.uiuc.edu/speech/mrihttp://www.ifp.uiuc.edu/speech/mri
Purpose: Normative data for articulatory therapy, speech synthesis, speech science.
3mm Multislice, 750ms/image, 25 seconds breath hold.
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Normative Tagged Cine-MRINormative Tagged Cine-MRIStone et al., 2001Stone et al., 2001
Purpose: Direct observation of biomechanical quantities.
Limitation: 32 repetitions per image sequence.
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Diffusion Tensor MRI, Bovine TongueDiffusion Tensor MRI, Bovine TongueWedeen et al., 2001Wedeen et al., 2001
Purpose: Muscle segmentation, structure.
Limitation: Long acquisition => animal specimens.
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Clinical Objective: Surgical PlanningClinical Objective: Surgical PlanningKacker, 2000Kacker, 2000
Beckwith-Wiedemann Syndrome
Normal intelligence, personality.
At least 9 published resection methods; no quantitative comparison of results.
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Finite Element Modeling of SurgeryFinite Element Modeling of Surgery
Objective of Proposed Preliminary Study:
Simulate effects of two common surgeries.
Limitation: detailed knowledge of structure & biomechanical properties.
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Clinical Data: Surgical, Cadaver Clinical Data: Surgical, Cadaver SamplesSamples
Microscopic imaging of surgically excised tissue,
Diffusion tensor imaging of muscle structure (goal: first DTI of human tongue).
Target Resolution: fascicle thickness = 0.1mm.
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Clinical Data: Pre-operative and Clinical Data: Pre-operative and Post-operative MRIPost-operative MRI
Objective: Surgical PlanningObjective: Post-surgical follow-up, correlation of
anatomical and behavioral variablesLimitation: Muscle-Muscle Segmentation
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Clinical: Kinematic DiagnosisClinical: Kinematic Diagnosis
Objective: Identify correlations between anatomy, behavior.
Limitation: Speed.
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Difficult Imaging ProblemsDifficult Imaging ProblemsSegmentation: Transverse and longitudinal
muscle indistinguishable w/o diffusion weighting.
Diffusion Weighting: Ambiguous in presence of blood flow.
Speed: Sedated: 20 minutes.
Breath hold: 5 seconds.
Dynamic: 10-50 ms.
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Possible Solution: SegmentationPossible Solution: Segmentation
Bayesian image segmentation -- combine: Prior knowledge (other segmented volumes)
Ambiguous anatomical image
Ambiguous diffusion tensor image
User-supplied "hints"
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Possible Solutions: SpeedPossible Solutions: SpeedImage-recognition based image
reconstruction RIGR (Liang 1992): Morph a prior image to
match partial k-space data.
Prior information about tongue shape, e.g. from factor analysis of normative tongue shapes (Hasegawa-Johnson & Zheng, 1999):
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ConclusionsConclusionsSpeech Science Research Issues
Muscle fiber organization
Strain dynamics of soft tissue
Clinical Applications Surgical planning
Diagnosis of biomechanical defects
Difficult Imaging Problems Segmentation of inter-muscle boundaries
High-speed dynamic imaging