preformulasi asetosal

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RANCANGAN FORMULA Formula Acuan 1. Aspirin® protect 100 mg (Bayer) Acetyl salisylic acid 100 mg Maize starch Cellulose powder Methacrylic acid – ethylacrylate copolymer 1:1 dispersion 30% Polysorbat 80 Sodium Dodecylsulfate Talc Triethyl citrate Enteric-coated tablet with 100 mg acetylsalicylic acid (Bayer) 2. Acetylsalicylic Acid Tablets (Handbook of Pharmaceutical Manufacturing Formulations) Acetylsalicylic acid, 40 mesh 400.00 mg Cellulose (microcrystalline) (AvicelTM PH101) 55.60 mg Starch (pregelatinized) 21.40 mg Stearic acid 2.20 mg Croscarmellose sodium (Ac-Disol) 10.00 mg Fumed silica 3.20 mg 3. Aspirin tablets (Erum S, et al.)

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RANCANGAN FORMULAFormula Acuan1. Aspirin protect 100 mg (Bayer)Acetyl salisylic acid 100 mgMaize starchCellulose powderMethacrylic acid ethylacrylate copolymer 1:1 dispersion 30%Polysorbat 80Sodium DodecylsulfateTalcTriethyl citrate

Enteric-coated tablet with 100 mg acetylsalicylic acid(Bayer)2. Acetylsalicylic Acid Tablets (Handbook of Pharmaceutical Manufacturing Formulations)Acetylsalicylic acid, 40 mesh 400.00 mgCellulose (microcrystalline) (AvicelTM PH101)55.60 mgStarch (pregelatinized) 21.40 mgStearic acid 2.20 mg Croscarmellose sodium (Ac-Disol)10.00 mgFumed silica 3.20 mg

3. Aspirin tablets (Erum S, et al.)

Formula ModifikasiItem Ingredientsmg/tablet%g/500 tablet

1Aspirin1007550

2Lactose26,672013,335

3Corn Starch53,752,5

4Aerosil1,671,250,835

Total133,3410066,67