prebiotics support for your natural microbiota and your health · 2018-10-05 · beneficial...

Prebiotics – support for your natural microbiota and

your health

Anke Sentko, Vice President Nutrition Communication & Regulatory Affairs

18090p-ASO-FoodTechSummit, Septemer 26, 2018

Setting the scene

2

© 2018 BENEO

Scientific milestones in the prebiotic research

BENEO as pioneer since the 1990s

*Roberfroid et al. (2010) Br J Nutr 104(S2):S1-S63. https://www.ncbi.nlm.nih.gov/pubmed/20920376 3

First observations that beneficial bifidobacteria

are specifically stimulated by fructo-

oligosaccharides

First prebiotic definition published:

Roberfroid & Gibson

20102008200419951980s 2017

"The prebiotic effect is now a

well established scientific fact"*

ISAPP: International Scientific Association

for Probiotics and Prebiotics review

The prebiotic concept becomes global

BENEO (Orafti) has supported microbiota research

of European scientists for more than 20 years

© 2018 BENEO

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Publications

Significant attention has been given to the beneficial effects of

prebiotics

• Since concept was first defined, it has been subject of intensive research

• Prebiotic research has continued at a rapid pace with >2000 research articles published

over the past 5 years>2000 articles

4

© 2018 BENEO

Prebiotics and probiotics are both beneficial for health

But what is the difference?

* https://isappscience.org/prebiotic-definition-updated-isapp/ ; https://isappscience.org/probiotics/

• What are prebiotics?

• Food/feed for beneficial microbes

that live in our colon.

• eaten by the ‘good’ gut microbes as

their “favorited dish”

• positive impact on the gut environment,

with an overall health benefit."

• What are probiotics?

• live microorganisms from other

sources than the human gut

• Swallowed and need to survive the

stomach and small intestine passage

• Need to provide strain-specific evidence

in humans about their health benefit

https://isappscience.org/prebiotic-definition-updated-isapp/

https://isappscience.org/probiotics/

© 2018 BENEO

Drivers of digestive health

Consumers are informed about digestive health

Source: BENEO’s consumer research on prebiotics, 2017

consumers have read some pieces lately

on the topic of digestive health

Almost 1 in 3 (30%)

Almost 1 in 4 (23%)

Very/extremely interested in the gut

microbiome(how good and bad bacteria in your gut impacts your overall health)

52%

Gut health books

Social media

Scientific developments in the media

© 2018 BENEO

Drivers of digestive health

The gut is our second brain

Source: New Nutrition Business, 10 key trends in Food, Nutrition & Health 2017 & HFI, Global Trend Study, 2018 & BENEO’s qualitative research, 2018 (ongoing)

The gut is a second brain, capable of influencing a variety of processes in the body

79% thinks digestive

health plays an

extremely/very

important role in

physical health

67% thinks digestive

health plays an

extremely/very important

role in mood

65% thinks digestive health

plays an extremely/very

important role in daily

energy levels



important role in immune

function



important role in weight

management



important role in physical

appearance

The colon –

the starting point

for the prebiotic

outreach

8

© 2018 BENEO

…. and more!

The microbiota is influencing many things…..

Hormoneproducing

organ

Microbiota(population &

composition)

Nervous

system(our second

brain)

Immune

system!

Barrierbetween in-

and outside:

Mucosa

Weight

management

Blood sugar

management

Improved

calcium

intake & bone

support

9

Regularity

The gut microbiota

What is a healthy gut microbiota????

What if the gut microbiota is out of balance?

What are the preferred microorganisms to support a healthy

microbiota and a balanced microbiota?

10

© 2018 BENEO

Characteristics of the microbiota with implications to the host

Peptolytic fermentation

- amines

- putrefactants

- phenols, indoles

- N-nitroso compounds

- ammonia

Proinflammatory agents

Lipopolysaccharides

Toxic load of luminal

contents/faeces

- genotoxicity

- cytotoxicitySaccharolytic fermentation

Short chain fatty acids- acetate

- butyrate

- propionate

- lactic acid

- pH reduction

Secondary metabolism- vitamin synthesis

- bacteriostatic/-cidal compounds

Pathogenicity

Exotoxins

Toxic volatiles

- hydrogen sulphide

- mercaptanes Secondary enzymes

- azoreductase

- nitroreductase

- beta-glycosidases

- alpha-glucuronidases

Inert gases

- carbon dioxide

- methane

- hydrogen

Immuno-modulating effects

11

© 2018 BENEO

Saccharolytic fermentation supports health

Inspired by O’Keefe, S. J. D. (2016) Diet, microorganisms and their metabolites, and colon cancer

Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2016.165 and Gibson et al. (2017) Nat Rev Gastroenterol Hepatol:.

http://www.nature.com/nrgastro/journal/vaop/ncurrent/pdf/nrgastro.2017.75.pdf12

http://www.nature.com/nrgastro/journal/vaop/ncurrent/pdf/nrgastro.2017.75.pdf

© 2018 BENEO

Imbalances in the gut microbiota have been linked to various

diseases….

*Literature search and interpretation by Beneo Insitute, based on 24 pertinent publications13

Imbalances in the gut microbiota are linked to:

• Asthma and allergy

• Infections

• Colic and functional gastrointestinal disorders in infants

• Inflammatory bowel disorders

• Autism spectrum disorders

• …. Low numbers of bifidobacteria are linked to

several disease risk associations*:

• Type 2 diabetes

• Inflammatory bowel disease (IBD)

• Ulcerative colitis

• Crohn’s disease

• Coeliac disease

• Obesity / metabolic disorders

© 2018 BENEO

ISAPP 2017 Prebiotic Definition

Gibson et al. (2017) Nat Rev Gastroenterol Hepatol:Advanced online publication. http://www.nature.com/nrgastro/journal/vaop/ncurrent/pdf/nrgastro.2017.75.pdf [Accessed 19 June 2017] 14

A substrate that is selectively utilized by host

microorganisms conferring a health benefit

Changed:

• Prebiotics not limited to gastrointestinal tract

• Possibly includes non-carbohydrate substances and

diverse categories other than food

• Definition applies also for the prebiotic use in animals

Confirmed:

• Selectivity is key! ( criterion that

distinguish prebiotics from many other

substances)

• Selective effect must evoke a net health

benefit!

http://www.nature.com/nrgastro/journal/vaop/ncurrent/pdf/nrgastro.2017.75.pdf

© 2018 BENEO

HOME

other bacteria (neutral, harmful)

Beneficial bacteria

What does selective fermentation mean?

Dietary prebiotics

../Local Settings/Temporary Internet Files/user/My Documents/Sales Presentation CN/translation/Home.pps

© 2018 BENEO

Chicory root fibres are proven prebiotics!

1 Gibson et al 2017. Nat Rev Gastroenterol Hepatol. 14(8):491-502. https://www.nature.com/articles/nrgastro.2017.75 16

Chicory root fibres are

proven prebiotics and

are the most-well

studied.

Pro

ve

np

ote

nti

al

can

did

ate

s

po

ten

tia

l c

an

did

ate

s

potential candidates:

a lack of human studies showing

the health benefit, a crucial part

of the definition for prebiotics.

© 2018 BENEO

Strong body of scientific evidence for prebiotic chicory root fibres

The prebiotic effect of chicory root fibers

(inulin and oligofructose) is a

scientifically proven fact

>30 studies in adults

With as low as 5g chicory root fiber

per day the increase in Bifidobacteria

is demonstrated

>15 studies in infants and children

© 2018 BENEO

Inulin-type fructans selectivity on microbiota evidenced with next-

generation technique!

Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-313271 18

The study was conducted at the University of Leuven,

Belgium by Professor Jeroen Raes from the

Department of Microbiology and Immunology and

Professor Kristin Verbeke from the Translational

Research in Gastrointestinal Disorders Unit

Chicory root fibre selectively effects the human gut microbiota

© 2018 BENEO

Next-generation sequencing for gut microbiota analysis

Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-313271

Micka et al. (2017) Int J Food Sci Nutr Feb 68 (1):82–89. doi: 10.1080/09637486.2016.1212819. 19

• Randomised, placebo controlled, double-blind, cross-over design

• 44 participants with mild constipation consuming 12 g/d (3x4 g) Orafti®Inulin (compared to

maltodextrin) over 4 weeks

• Feacal samples were obtained before and after intervention and wash-out period for:

• Microbiota analysis (phylogenetic profiling) Next-generation sequencing

© 2018 BENEO

Selective growth of bacteria –

Prebiotic effect proven with state-of-the-art methodology

Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-31327120

The umbrella view on the colon’s

ecosystem demonstrates:

• Selective effect of chicory root fiber on the

human gut microbiota with newest

methodology

• Amongst almost 300 genera detected the

abundance of only 3 genera changed

significantly with inulin intake

• Bifidobacterium increased

• Anaerostipes increased

• Bilophila decreased

P: placebo, I: inulin

© 2018 BENEO

Improved well-being! Wellbeing parameters assessed with PAC-QoL(Patient assessment of Constipation Quality of Life)

Marquis et al. (2005) Scand J Gastroenterol 40(5):540–551. doi: 10.1080/00365520510012208 21

• PAC-QoL• Subscores used for „discomfort“ and „satisfaction“ comprising in total 9 questions

• Ratings from 0 (not at all, none of the time) to 4 (extremely, all of the time)

• Measuring the impact constipation has had on daily life during the past 2

weeks

• Discomfort: • „To what extent or intensity have you felt bloated to the point of bursting?“

• „How much of the time have you felt the need to have a bowel movement but not

been able to?“

• …

• Satisfaction: • „How much of the time have you had fewer bowel movements than you would

like?“

• „To what extent or intensity have you been satisfied with the regularity of your

bowel movements?“

• …

RESULTS of PAC-QoL:

Physical discomfort

score: No difference

Satisfaction: significant

improvement with chicory

root fibre

© 2018 BENEO

Improved digestive well-being by chicory root fiber

Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-313271 22

• Correlation between Bilophila abundance variation and changes in stool consistency was

found

&

• Correlation between the reduced numbers of Bilophila in the gut and improved

constipation-related wellbeing parameters ( Quality of Life questionnair) was observed

Author’s conclusion:

“the observed association between Bilophila decreases on inulin consumption

and quality-of-life increase urges the need for further research on

the role of this taxon in host well-being.”

Cross Talk

23

© 2018 BENEO

…. and more!

The microbiota is influencing everything…..

Hormoneproducing

organ

Microbiota(population &

composition)

Nervous

system(our second

brain)

Immune

system!

Barrierbetween in-

and outside:

Mucosa

Weight

management

Blood sugar

management

Improved

calcium

intake & bone

support

24

Regularity

© 2018 BENEO

From the colon to other organs of the body: The reach-out of the

microbiota …

25

BrainLung

Neurotransmitter

SerotoninCytokines

Bacterial metabolites

SCFA, others

GLP-1, PYY,..

microbiotaLarge intestine

Immune cellsNervous system Hormonal system

Kidney

Liver

Blood

Muscles

Metabolite reach out to…..

© 2018 BENEO

From gut-brain to gut-skin, gut-bone, gut-muscle axis etc.

https://www.nutraingredients.com/Article/2017/01/12/Heard-of-the-gut-brain-axis-Meet-the-gut-skin-axis 26

https://www.nutraingredients.com/Article/2017/01/12/Heard-of-the-gut-brain-axis-Meet-the-gut-skin-axis

Digestive wellbeing by chicory root fiber

Improved regularity and digestive well-being in adults and

children

27

© 2018 BENEO

Support of digestive health and well being by chicory fiber…

Micka et al. (2017) Int J Food Sci Nutr. 68(1):82-89. 28

run-in

2 weeks

period 1

4 weeks

wash-out

2 weeks

run-in

2 weeks

period 2

4 weeks

• Inulin vs Maltodextrin (control)

• 3x4g per day

• Inulin (and MDX) was taken with 200 ml of drinks at breakfast,

lunch and dinner

• Primary outcome: frequency of bowel movements

• Design:

• Randomized

• placebo-

controlled

• double-blind

• cross-over

• mono-center

• n = 44 healthy adults

mildly constipated

• Duration of

intervention 4 weeks

© 2018 BENEO

Improved regularity


Bowel movement frequency per week after a 4 week intervention with 3x4g/d

Orafti®Inulin (compared to maltodextrin) significantly improved!

p = 0.038

*

0

1

2

3

4

5

Maltodextrin Orafti® Inulin

Bo

we

l m

ove

me

nts

/we

ek

Maltodextrin

Orafti® Inulin

© 2018 BENEO

…. A complex orchestra that is positively influenced by chicory root

fibers …..

30

not digestible in small intestine

water bindingcapacity

softer stools

bacterial fermentationin large intestine

bacteria

bowel content

faecal bulk

intestinal transit time

bowel movementfrequency

gas production

SCFA production

chemical stimulationof peristaltic reflex

Physiological mechanism fully

accepted by EFSA

The prebiotic fermentation of

chicory inulin plays a key role!

water content ofdigesta/faeces

BENEO´s 13(5) EFSA dossier submitted in May 2014, received a positive Opinion in January 2015

© 2018 BENEO

Digestive comfort

Assessed with a “discomfort” diary (5-point scale) (3x4g/d intake)


IIntervention

InulinP Placebo

© 2018 BENEO

Improved well-being!

Health related QoL questionnaire specific for constipated subjects

32

• PAC-QOL (Patient-Assessment of Constipation

Quality of Life)

• a validated instrument to assess QoL in patients suffering from

constipation.

• Selected validated test blocks: physical discomfort and

satisfaction dimension

Physical discomfort score:

No difference between Chicory root fiber and placebo

Satisfaction:

significant improvement with chicory root fibre

Micka et al. (2017) Int J Food Sci Nutr. 68(1):82-89.

© 2018 BENEO

Does oligofructose improve bowel regularity in chronically

constipated with low fibre intake?

• Does oligofructose improve bowel functions in subjects with self-reported chronic

constipation and a diet habitually low in dietary fibre?

• Can a dose-response relationship be established between oligofructose intake and stool

frequency?

• How well is oligofructose tolerated?

Buddington et al. (2017) Nutrients 9(12):1372. http://www.mdpi.com/2072-6643/9/12/1372/pdf (Open Access) 33

http://www.mdpi.com/2072-6643/9/12/1372/pdf

© 2018 BENEO

Study design

• Placebo-controlled, randomised, parallel, double-blind trial

• Stepwise increase from 5 g, 10 g to 15 g Orafti®P95 per day versus maltodextrin

as placebo over 15 weeks.

• Each dosage was given in 3 sachets per day over 4 weeks

• 97 North American adults with mild constipation (3 or less bowel movements per week)

associated with a low fibre intake

• Assessment of stool frequency and gastrointestinal sensations



© 2018 BENEO

Oligofructose improves bowel regularity

• Intake of 15 g/d Orafti®P95 showed a significantly higher stool frequency per week

• Effects were even more pronounced when subjects consumed a certain, but still

insufficient amount of fibre in their usual diet (>13 g fibre).

• Significantly higher stool frequency with 10 g/d versus study start and with 15 g/d versus placebo.

vs. baseline

vs. placebo

vs. baseline



© 2018 BENEO

Oligofructose is well-tolerated

• Very low gastrointestinal sensations rated on a 0 to 10 scale in all groups.

• Compared to study start “noise”, “pressure” and “pain” significantly decreased in the

oligofructose group with higher dosages.

0

1

2

3

4

5

6

7

8

9

10

0 g 5 g 10 g 15 g 0 g 5 g 10 g 15 g

Placebo Oligofructose

Bloating Gas

Different letters indicate a significant difference within a group (oligofructose or placebo)

Buddington et al. (2017) Nutrients 9(12):1372. http://www.mdpi.com/2072-6643/9/12/1372/pdf (Open Access)

(significant difference: 5 g placebo vs. 10 g and 15 g placebo)36


© 2018 BENEO

Digestive health in children

Closa-Monasterolo et al (2017): International journal of food sciences and nutrition 68 (5), S. 587–594. DOI: 10.1080/09637486.2016.1263605. 37

Inulin-type fructan intervention

V1 Screening

V3 After 3 wk

intervention

V2 RandomisationFinal inclusion

Follow-upRun-In/Baseline Maltodextrin Follow-up

2 wk 6 wk 3 wk

V4 End of

intervention

Children

V5End of

follow-up

• Double-blind, randomised, placebo-controlled

parallel group trial

• N = 17

• 2-5 year old constipated children, recruited at the

University Hospital Sant Joan de Reus (Spain)

• 2x 2g/day oligofructose/Inulin mixture vs.

maltodextrin in yoghurt/fresh cheese, during 6

weeks

© 2018 BENEO

Key Findings

Closa-Monasterolo et al (2017): International journal of food sciences and nutrition 68 (5), S. 587–594. DOI: 10.1080/09637486.2016.1263605. 38

Gastrointestinal

comfort:

No increase in

flatulence or distension

in the

inulin/oligofructose

group

• Inulin-type fructans lead to a change in stool consistency

(softer stools) after 4 or 6 wks

• Prebiotic inulin-type fructans improve the stool

consistency in functionally constipated 2-5 y old children

• Effect significant even when other confounders (e.g.

baseline or dietary variables) considered

© 2018 BENEO

Kindergarten children study: softer stools with chicory root fibres

Lohner et al. (2018) J Nutr 102(Suppl 2):261. https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxy120/5048772 39

Significantly softer stools

in the normal range

compared to placebo

**

** **

**p<0.01

Parents categorised the

stool consistency with the

Bristol Stool Chart

ranging from 1 (very hard)

to 7 (entirely liquid).

https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxy120/5048772

© 2018 BENEO

Art. 13(5) - Orafti®inulin & normal bowel function

Ref. Commission Regulation (EU) 2015/2314 of 7 December 2015 authorising a health claim made on foods, other than those referring to the reduction of disease risk and to children's development and health and

amending Regulation (EU) No 432/2012; available at:

http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32015R2314&rid=140

http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32015R2314&rid=1

© 2018 BENEO

Overview on other fibre related “bowel function” health claims

Legal Disclaimer: This information is presented in good faith and believed to be correct; nevertheless no responsibility/warranties as to the completeness or accuracy of this information are taken. This information is supplied upon the

condition that the persons receiving the same will make their own determination as to its suitability for their purposes prior to use. 41

Ingredient Claims wording Type of

health claim

EFSA

Opinion/status

Regulation

Native

chicory inulin

“contributes to normal bowel function by

increasing stool frequency”

13(5) Finished (ON-3951),

11.12.2014

positive

Reg. (EU) 2015/2314

(Authorised health

claim)

Fibersol-2

(resistant

Maltodextrin)

“contributes to a normal bowel function by

increasing faecal bulk, stool frequency and by

reducing colonic transit time”

13(5) Withdrawn,

23.07.2018

n/a

Polydextrose “contributes to an improved bowel function by

increasing stool bulk”13(5) Finished (ON-4480),

20.04.2016

negative

Reg. (EU) 2017/1200

(Non-authorised health

claim)

scFOS from

sucrose

“maintain normal intestinal regularity” 13(5) Finished (ON-4366),

11.12.2015

negative

Reg. (EU) 2017/1201

(Non-authorised health

claim)

scFOS from

sucrose

“reduce intestinal discomfort” 13(5) Withdrawn,

11.10.2012

n/a

© 2018 BENEO

Art. 10(3) reference “prebiotic” + Art. 13(5) health claim for

Orafti®inulin and bowel function

Legal Disclaimer: This information is presented in good faith and believed to be correct; nevertheless no responsibility/warranties as to the completeness or accuracy of this information are taken. This information is supplied upon the

condition that the persons receiving the same will make their own determination as to its suitability for their purposes prior to use. Confidential business information.42

Art. 10(3)

Art. 13(5)* Chicory inulin contributes to normal

bowel function by increasing stool

frequency

Front of pack Back of pack

Ingredients: …Nutrition Declaration:

* Chicory inulin contributes to normal

bowel function by increasing stool

frequency

This food, containing 4 g chicory inulin per

portion, is ideal as part of a varied and

balanced diet and a healthy lifestyle. The

beneficial effect is obtained with a daily

intake of 12 g chicory inulin, this means 3

portions of this food or from other foods,

containing chicory inulin.”

CoU

Art. 13(5)

Art. 10(3)

Support of the “inner resistance”

43

© 2018 BENEO

Healthier children with prebiotic chicory root fibres

Improved digestive health and immunity

Lohner et al. (2018) J Nutr 102(Suppl 2):261. https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxy120/5048772

*degree of polymerization (DP) ≥11 approx. 25-30% (on g/100 g DM), average DP of about 7 to 8 44

• 219 healthy kindergarten children aged 3 to 6 years

consumed daily 6 g Orafti® inulin-type fructans with

shorter and longer chains* versus maltodextrin as

placebo for 6 months given as supplement during winter

• Prebiotic chicory root fibres are well tolerated and show positive effects on:

Gut microbiota

Significantly higher levels of bifidobacteria

and lactobacilli

Immune system

Significantly less infections with fever

and sinusitis

Stool consistency

Significantlysofter stools in the

normal range

https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxy120/5048772

Strengthening the gut barrier function

45

© 2018 BENEO

Orafti®Synergy1 prevents a leaky gut!

Schroeder et al. Cell Host & Microbe 23, 27–40, January 10, 2018

46

Background:

The inner colonic mucus layer separates

gut bacteria from the host and thus is an

important protective physical barrier

between the outside world including trillions

of gut bacteria and the inside of a human

being.

Diet affects microbiota composition and the

microbiota influences the mucosa.

Key results (mice study):

• A Western-Style diet (WSD) leads to

• increased mucus penetrability and

• decreased mucus thickness, and

• a reduced growth rate of the inner mucus

layer, and

• is accompanied by distinct alternations in the

microbiota composition

• Orafti®Synergy1 supplementation

prevents the Western-Style-diet-induced

increase in mucus penetrability!

Blood Glucose Management

47

© 2018 BENEO

Health benefits of lowering blood glucose levels

International Scientific Consensus:

• Reducing the blood glucose response of

a meal is a beneficial physiological effect

• Carbohydrate-based diets with low effect

on blood glucose levels

• Improves blood glucose control in people with

type 2 and type 1 diabetes

• Reduces the risk of type 2 diabetes

• Reduces the risk of coronary heart disease

• Likely reduces total body fat mass and supports

body weight management

Sources: Augustin LS, et al (2015) Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis 25 (9)

795-815.48

© 2018 BENEO

BENEO

Helping to support a healthy blood sugar profile

• There is a need for more products on the market that help consumers achieve and

maintain a healthy blood sugar profile

• BENEO’s ingredients can help support blood sugar management by

Scientific

substantiation &

approved health

claims

Improving

physiological

properties

Reducing blood

sugar & insulin

responses

Improving

carbohydrate &

nutritional quality

Lower blood sugar response of BENEO’s ingredients confirmed in >50 human intervention studies!

49

© 2018 BENEO

Blood sugar management matters to all age groups!

Lowering the blood glucose curve with chicory root fibres

50

© 2018 BENEO

2017 review continues to confirm

The low blood sugar response of chicory root fibres

Lightowler et al. (2017) Eur J Nutr. https://www.ncbi.nlm.nih.gov/m/pubmed/28255654 51

The effect of sugar reduction with chicory root

fibres on blood sugar and insulin response

has been investigated in:

• 9 human trials (including normal & overweight

individuals) showing that the more sugar you

replace with chicory fibres the lower the

blood sugar response

• Already 20% sugar replacement shows a

significant effect

• Demonstrated in different product applications

All studies show a reduced blood glucose response with chicory fibres

https://www.ncbi.nlm.nih.gov/m/pubmed/28255654

Sugar Reduction

52

© 2018 BENEO

My Sunday afternoon favorite…..

• 4 eggs

• 1 spoonful Vanilla sugar or/and

citron powder

• Some salt

• 1 spoonful of baking powder

250g Butter

250g Wheat

flour powder

250g Sugar

skip the

sugar, 1/3 of

the dough

would be

missing!

53

© 2018 BENEO

Simply replacing sugar is not enough

BENEO has the solutions

We see the need… …We know what we

want to achieve

Yes, and…

…how can we do it?

Which ingredients

qualify?

Lower blood glucose rise

Reduced energy or increased fat burning

Fibre enriched

Sugar reduction +

54

© 2018 BENEO

Simply replacing sugar is not enough

The type and quality matters

REPLACEMENT TYPE EFFECT

High glycaemic

Low glycaemic

Same calories

More calories

Reduced calories

Increased fat burning

Fibre enrichment

Fibre enrichment + prebiotic

+ digestive health

25-30% replacement & no increase in calories

compared to similar products

Type of

replacement

matters!

Sugar

reduction

++ +

++ +

++ +

+

++ +

++ +

++ +

-

-

-

-

-

-

-

++ +-

++

55

YES!

and

© 2018 BENEO

Chicory root fibres: The “two in one” approach

Lower rise in blood sugar with fibre enrichment

Fibre as a non-digestible carbohydrate = No glucose release

Lowers blood sugar response and insulin release by replacing

high glycaemic carbohydrates

Prebiotic fibre enrichment with chicory fibres

Positive EFSA opinion

EU-approved claim related to the

lower rise in blood sugar

Low blood sugar response plus prebiotic fibre

56

Summary and outlook

57

© 2018 BENEO

A healthy nutrition and lifestyle is needed NOW!

International Diabetes Federation. IDF Diabetes Atlas 8th Edition 2017. http://www.diabetesatlas.org/ 58

OECD (2017), OECD Health Statistics 2017. www.oecd.org/health/health-data.htm

Projected rates of obesityTop 10 countries/territories for number of

adults with diabetes (20-79 years),

2017 and 2045

Mexico:

No 5 in 2017

No 4 in 2045

© 2018 BENEO

The dietary fibre gap:

North and South America (females/males)

USA

Canada

Mexico Brazil Colombia

-25

-20

-15

-10

-5

0

Delta between dietary fibre intake and recommendation in g/d

females males

Literature search by BENEO Institute (2018) 59

© 2018 BENEO

The chicory root fiber map – the prebiotic outreach

PREBIOTIC

Chicory root fiber fermentation leading

to selective microbiota growth

Feeling of digestion

IBS Gut-Brain-Axis

Regular regularity

Quality of Life improvement

Metabolomicapproach

Bilophila reduction & QoL

Prevention & well-being

by prebiotic fermentation

Blood Sugar Management

Cholesterol lowering

Inner protection

Maternal nutrition & outreach

Ca absorption & Bone density

Weight management

Avoiding the negative

proteolytic fermentation

effects

Sugar reduction

“plus”

Healthy ageing

Type1 diabetes

improving inflammation

Fiber enrichment

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THANK YOU!

Questions?

61

Office address:

Anke Sentko

VP Regulatory Affairs &

Nutrition Communication

BENEO GmbH

Maximilianstraße 10

68165 Mannheim

Germany

[email protected]

Your local contact:

Thomas WEBER

Area Sales Manager BENEO

Mexico

Phone: +52 442 341103

Mobil: +52 442 35447

[email protected]