pre test !!!!!!. how many classes of hiv meds are currently available? 1. 1 2. 2 3. 3 4. 4 5. 5

Pre Test !!!!!!

How many classes of HIV meds are currently available?12345

A side effect with Reyataz (atazanavir) which is reversible when discontinued is?Discoloration of the fingernail and toe nailsHyperbilirubinemiaKidney FailureLiver Failure

HIV stands for:Hawaiian Island VisitorsHuman Immunodeficiency VirusHepatitis Injection VaccineNone of the above

The first three steps involved in HIV cell entry include all of the following except:FusionIntegrationAttachmentCo-receptor binding

All the following are combination formulations except for?EpivirCombivirEpzicomTrizivir

Like Hepatitis C, HIV isA harmless virusA bloodborne virusA curable virusNone of the above

What HIV med causes Vivid Dreams? Selzentry (Maraviroc)Sustiva (Efavirenz)Lexiva (Fosamprenavir)None of the above

Living or working with a person who is infected with HIV can cause someone to get HIVFalseTrue

What must one be careful of when taking Ziagen (abacavir)?AcneCoughRunny noseHypersensitivity reaction

The most common side effect found with the D drugs is?

DiarrheaNauseaHeadachesPeripheral Neuropathy

Consistent and correct condom use can prevent HIVTrueFalse

HIV can be transmitted by:Sharing dirty needlesBloodSemenVaginal FluidsAll of the aboveNone of the above

Before beginning Selzentry (maraviroc) what type of lab test must be performed?CBC w/ DiffHct & HgbTrophileLFT

The only HIV medication currently on the market which is injected is?RetrovirFuzeonCrixivanCombivir

One of the body fluids that can transmit HIV is:

TearsSalivaUrineBreast milk

All of the following agents are Protease Inhibitors except?Prezista (darunavir)Lexiva (fosamprenavir)Viracept (nelfinavir)Ziagen (abacavir)

Trizivir, although is a 3 med combo it should not be used alone because.It is too expensiveThere are too many side effectsIt does not sustain good results as triple nuc therapyNone of the above

The first medication used in HIV was? Crixivan (Indinavir)Invirase (Saquinavir)Sustiva (Efavirenz)Retrovir (Zidovudine)

What is the least number of HIV meds that can be used to treat HIV?12345

What HIV med is used as a booster?Viracept (Nelfinavir)Reyataz (Atazanavir)Norvir (Ritonavir)Viramune (Nevirapine)

The newest HIV medication combined into one pill and taken once a day by two different manufacturers is?TrizivirCombivirAtriplaEpzicom

HIV Medications 101

Fred Cruz, R.Ph.Pharmacist-In-Charge CarePlus CVS/pharmacy

My Personal Story

TEST !!!!!

What is Freds male dogs name?ThorZeuzHerculesRudy

What is Freds female dogs name?XenaAphroditeAthenaNone of the above

What is Freds partners occupation?PharmacistArchitectPolice officerDoctor

How many pictures did it take to get the family picture of the dogs?5075100125

What made Fred interested in working with HIV?HIV medications are always changingHis friend a pharmacist had a brother who died of HIVFred has had many friends die of HIVAll of the above

CarePlus Pharmacy Team

HIV Myths

HIV stands for:Hawaiian Island VisitorsHuman Immunodeficiency VirusHepatitis Injection VaccineNone of the above

Living or working with a person who is infected with HIV can cause someone to get HIVFalseTrue

Like Hepatitis C, HIV isA harmless virusA bloodborne virusA curable virusNone of the above

Consistent and correct condom use can prevent HIVTrueFalse

HIV can be transmitted by:Sharing dirty needlesBloodSemenVaginal FluidsAll of the aboveNone of the above

One of the body fluids that can transmit HIV is:

TearsSalivaUrineBreast milk

HIV Life Cycle

Videos

HIV: Antiretroviral TherapyHIV RNAHIV DNAHIVNucleusHost Cell Non-Nucleoside RTINucleoside RTIIntegrase InhibitorsProtease InhibitorsEntry Inhibitors

Classes of HIV MedsProtease Inhibitors (PIs)Nucleoside Reverse Transciptase Inhibitors (NRTIs)Non-Nucleoside Reverse Transciptase Inhibitors (NNRTIs)Entry InhibitorsIntegrase Inhibitors

Classes of HIV meds in the pipelineMaturation InhibitorsCellular InhibitorsImmune Based Therapies

NNRTI87919294959697989900888990NRTIPIApproved AntiretroviralsRetrovirNorvirInviraseCrixivanFortovaseKaletraViraceptZiagenCombivirVidexHividZeritEpivirTrizivirRescriptorSustivaViramune01VireadEmtrivaReyataz020393AgeneraseFIFUZEONRetrovir, Epivir, Combivir, Ziagen, Agenerase, Lexiva and Trizivir are trademarks of GlaxoSmithKline. Videx, Zerit, Sustiva and Reyataz are trademarks of Bristol-Myers Squibb. Norvir and Kaletra are registered trademarks of Abbott. Crixivan is registered trademark of Merck. Viramune is registered trademark of Boehringer Ingelheim. Viracept and Rescriptor are registered trademarks of Agouron. Viread and Emtriva are trademarks of Gilead. Hivid, Invirase, Fortovase and FUZEON are registered trademarks of Roche Laboratories.

Lexiva

HAART = High Active Anti-Retroviral Therapy

NRTIs (Nucleoside Reverse Transciptase Inhibitors)Combivir (zidovudine + lamivudine, AZT + 3TC) Emtriva (emtricitabine, FTC) Epivir (lamivudine, 3TC) Epzicom (abacavir + lamivudine, ABC + 3TC) Retrovir (zidovudine, AZT, ZDV) Trizivir (abacavir + zidovudine + lamivudine, ABC + AZT + 3TC) Truvada (tenofovir DF + emtricitabine, TDF + FTC) Videx & Videx EC (didanosine, ddI) Viread (tenofovir disoproxil fumarate, TDF) Zerit (stavudine, d4T) Ziagen (abacavir, ABC)

NRTIs in the PipelineRacivir (RCV) Amdoxovir (AMDX, DAPD) Apricitabine (SPD754, AVX754) Elvucitabine (ACH-126,443, Beta-L-Fd4C)

NNRTIs (Non-Nucleoside Reverse Transciptase Inhibitors)Intelence (etravirine, TMC-125) Rescriptor (delavirdine, DLV) Sustiva (efavirenz, EFV) Viramune (nevirapine, NVP)

NNRTIs in the PipelineRilpivirine (TMC-

PIs (Protease Inhibitors) Agenerase (amprenavir, APV) Aptivus (tipranavir, TPV) Crixivan (indinavir, IDV) Invirase (saquinavir, SQV) Kaletra (lopinavir/ritonavir, LPV/r) Lexiva (fosamprenavir, FPV) Norvir (ritonavir, RTV) Prezista (darunavir, DRV) Reyataz (atazanavir, ATV) Viracept (nelfinavir)

Entry Inhibitors Fuzeon (enfuvirtide, ENF, T-20) Selzentry (maraviroc, UK-427,857)

Entry Inhibitors in the PipelineVicriviroc (SCH-417690, SCH-D) PRO 140 TNX-355

Integrase InhibitorsIsentress (raltegravir, MK-0518)

Integrase Inhibitors in the PipelineElvitegravir (GS-9137)

HIV Treatment: Then and Now

DHS/HIV/PP

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Post Test HIV Meds 101