pre feasibility report for - welcome to...

Pre Feasibility Report

For

Proposed Synthetic Organic Chemical Manufacturing

Industry on land bearing survey no. 30, H No. 6+7+8/2,

6+7+8/4 to 17& 6+7+8/19 to 24 village Pam Tembhi,

Taluka Palghar, District Palghar

M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd.

March 2018

Pre-Feasibility Report for Proposed Synthetic Organic Chemical Manufacturing Industry at Village Pam Tembhi, Taluka-Palghar, District- Palghar.

1

Table of Contents

1. Executive Summary ........................................................................................................ 3

2. Introduction of the Project .............................................................................................. 6

I. Identification of project and project proponent: ................................................................. 6

II. Brief Description and Nature of the project. ...................................................................... 7

III. Need of the Project and its importance to the country and or region ..................................... 7

IV. Demand-Supply Gap ..................................................................................................... 9

V. Imports vs. Indigenous Production ................................................................................. 10

VI. Export Possibility ........................................................................................................ 10

VII. Employment Generation (Direct & Indirect) due to the project .......................................... 10

3. Project Description ....................................................................................................... 11

I. Type of Project ........................................................................................................... 11

II. Location of Project ...................................................................................................... 11

III. Details of Alternative Sites ........................................................................................... 15

IV. Size or Magnitude of operation ..................................................................................... 19

V. Project Description with process details ......................................................................... 26

VI. Raw Material Required .............................................................................................. 102

VII. List of Plant Machineries ............................................................................................ 102

VIII. Resource optimization/recycling and reuse ............................................................... 102

IX. Availability of water its source, Energy/ power requirement ........................................... 102

X. Schematic representations of the feasibility drawing which give information of EIA purpose.

105

4. Site Analysis ............................................................................................................... 106

I. Connectivity ............................................................................................................. 106

II. Land Form, Land Use & Land ownership ..................................................................... 106

III. Topography .............................................................................................................. 106

IV. Existing Land use pattern ........................................................................................... 106

V. Existing Infrastructure................................................................................................ 106

VI. Soil Classification ..................................................................................................... 107

VII. Climate data from secondary sources ........................................................................... 107

5. PLANNING BRIEF .................................................................................................... 109

I. Planning Concept ...................................................................................................... 109

II. Population Projection ................................................................................................. 109

III. Land use Planning ..................................................................................................... 109

IV. Assessment of Infrastructure Demand .......................................................................... 109

V. Amenities/Facilities ................................................................................................... 109


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6. Proposed Infrastructure .............................................................................................. 110

7. Rehabilitation and Resettlement (R & R) Plan ............................................................. 110

8. Project Schedule & Cost Estimates .............................................................................. 111

I. Likely date to start of Construction & likely date of completion ...................................... 111

II. Estimated Project Cost ............................................................................................... 111

9. Analysis of Proposal .................................................................................................... 111

I. Financial & Social Benefits ........................................................................................ 111


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1. Executive Summary

Ciron Group of Companies has been involved in developing a growing portfolio of

best-in-class pharmaceutical formulations in the health care arena. Ciron marks a

leading position in the field of pharmaceutical formulations manufacturing and

export. Ciron group is committed to observing ISO 9001:2008. Its manufacturing

plant holds WHO GMP certificate.

One of the Formulations manufacturing unit is in operational namely M/s. Ciron

Drugs and Pharmaceuticals Pvt Ltd. at N-118, MIDC,Tarapur, Boisar, District

Palghar.

Presently Ciron Group is involved in manufacturing of Formulations, all products

are supplied in the various permitted/suitable dosages in required pack sizes in the

form of small volume liquid parenterals, dry powder injectables, tablets (uncoated,

sugar coated, enteric coated, film coated, chewable, sustained release and dispersible

forms), capsules, dry syrups, liquid orals, sterile eye and ear drops; and topical lotions

according to the required suitable sizes.

Ciron also offers in API's, a large array of formulations with an independent, state-of-

the-art manufacturing facility. At Tarapur plant, Ciron manufacture small volume

parenteral (Vials, Ampoules, and Lyophilized Vials), Eye/Ear/Nasal Drops, Liquid

Orals, and external products. Palghar manufacturing unit includes manufacturing

facilities of tablets, capsules, liquids and dry syrups (dry powder) at Palghar.

Manufacturing wide range of tablets, capsules, syrups, injections, ointments, and

powders has demand in domestic as well as international market.

M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd. has proposed to establish new

manufacturing facility of API on land having total plot area of 28,200 sqm. &

proposed built up area of 14,097 sqm on land bearing Survey no. 30, H No. 6+7+8/2,

6+7+8/4 to 17& 6+7+8/19 to 24 village PamTembhi, Taluka Palghar, District

Palghar. The proposed manufacturing capacity of the unit will be 209.47MT/M. The

proposed products will be useful as active pharmaceutical ingredients for own drug

formulation unit as well as other units.

As per EIA Notification 2006, and its amendments thereof, the proposed industry

requires environmental clearance from MoEF&CC under the project or activity 5(f),

Category A for Synthetic organic chemicals industry (dyes & dye intermediates; bulk


4

drugs and intermediates excluding drug formulations; synthetic rubbers; basic organic

chemicals, other synthetic organic chemicals and chemical intermediates).

During construction and operation phase, proposed project will require manpower of

30 nos and 150 no.s respectively. During construction phase fresh water requirement

of 25KLD and in Operation phase fresh water requirement is 70KLD which will be

provided by competent authority. Management has proposed to install utilities viz.1

nos. of cooling tower of capacity 400TR, 1 no. of Brine plant of capacity 30 TR, 1 no.

of Nitrogen plant of capacity 120 CFM, 1 no. of Steam Boiler of capacity 1500

Kg/Hr, 2 no.s of Tank of capacity 2500 litres, Chilling plant (2 no.s) of capacity 120

TR, Chimney of height 30 meter, De-Minerlization water and RO system (1 no. of

capacity (3000 lit/hr).

The project will run on Zero Effluent Discharge (ZLD) scheme. Generated effluent

will be treated in inhouse ETP followed by Multi-Effect Evaporator system. Solid

waste will be categorized as hazardous & non-hazardous on the basis of its

characteristics. Hazardous waste will send to CHWTSDF, Mumbai Waste

Management Limited, Taloja and non-hazardous waste to the authorized vendor for

its disposal. The project synopsis is given in Table 1.1:

Table 1.1: Project Details in brief

Sr.no. Parameters Description

1 Project activity

Category as per EIA

Notification 14th September

2006 and amendments.

5(f)

Category A

2 Geographical coordinates

Latitude:190 47’ 36 .98”N

Longitude: 72043’ 03 .29”N

3 Total Production Capacity 209.47 MT/M (2513.64 MT/Year)

4 Total Plot Area 28,200 sqm

5 Built up area 14097 sq.m

6 Green area 4551.34sq.m

7 Fresh Water Requirement 70 KLD

8 Effluent Quantity 87KLD

9 Effluent Treatment • The domestic sewage will be treated in 10

KLD capacity STP.

• Industrial effluent will be treated in an

90KLD effluent treatment plant followed

by Mult-Effect Evaporator and will be


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utilized for gardening or recycled back in

the process.

• Reject water from RO will be evaporated

in evaporator.

• The reject water from RO, blow-down

from cooling, boiler and DM and washing

water from plant will be treated in ETP

followed by Multi- Effect Evaporator.

10 Domestic Waste Water

Treatment Sewage treatment plant of capacity 10

KLD will be proposed.

11 Boiler 1500 KG/Hr; 1 no.

13 Power Requirement Power Source :MSEDCL

The total power requirement for industry

is 3000kVA.

In case of Emergency, 750Kva x 2 no.sof

DG set will be installed on the site.

14 Work force

Construction phase:

Operation phase:

30no.s

150no.s

15 Total project cost INR 45.17 crores.

Keeping in consideration the Environment & Social safety, proposed project activity

will involve following studies such as Environment Impact Assessment (EIA),

Environment Management Plan (EMP), Disaster Management Plan (DMP), Risk &

Hazards study, Solid waste management, Public Consultation.


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2. Introduction of the Project

I. Identification of project and project proponent:

The proposed project activity falls under 5(f) for Synthetic organic chemicals

industry (dyes & dye intermediates; bulk drugs and intermediates excluding drug

formulations; synthetic rubbers; basic organic chemicals, other synthetic organic

chemicals and chemical intermediates). As the project is located outside the

jurisdiction of MIDC, hence falls in ‘A’ Category and will require Environmental

Clearance (EC) from the Expert Appraisal Committee (EAC-Industry2), MoEF

&CC, New Delhi as per Environmental Impact Assessment (EIA) Notification,

September 14, 2006 and amendments thereof.

In 1966, the Ciron Group of Companies has been involved in developing a growing

portfolio of best-in-class pharmaceutical formulations in the health care arena.

Mr.R.T. Shah commenced a small company, which has now grown into a large and

dynamic group. Currently, Ciron marks a leading position in the field of

pharmaceutical formulations manufacturing and export. Corporate Headquarters is

located in Mumbai, India with manufacturing units in Tarapur & Palghar.

Presently M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd. is involved in

manufacturing of formulations of drugs, all the products are supplied in the various

permitted/suitable dosages in required pack sizes in the form of small volume liquid

parenterals, dry powder injectables, tablets (uncoated, sugar coated, enteric coated,

film coated, chewable, sustained release and dispersible forms), capsules, dry

syrups, liquid orals, sterile eye and ear drops; and topical lotions according to the

required suitable sizes. Ciron also offers in API's a large array of formulations with

an independent, state-of-the-art manufacturing facility. Ciron has carved a niche for

itself in the sphere of operations of manufacturing Ampoules, Vials, Eye / Ear /

Nasal drops, Lyophilized products and Lyophilized bulk. Manufactured in India,

these niche products help make CIRON market-friendly in India and abroad.

Ciron has a regular overseas presence in over 36 countries. The company is widely

involved in manufacturing antibiotics, generic formulations, liquid orals, and dietary

supplements .The company has carved a niche for itself in the sphere of operations


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of manufacturing Sterile Products, at the renowned house of pharmaceutical

division.

II. Brief Description and Nature of the project.

Proposed unit will be involved in API manufacturing, which are used in drug

formulation mainly Antihistaminic, Antispasmodics, Anti-inflammatory, Anti-

hypotension, Anti- migraine/ anti-postpartum, Antispasmodics, Anti-psychotic,

anticonvulsant / antiepileptic drug, anti-GERD /Anti-acidity, Anti-shingles infection,

anti-diabetic, Anti-shock syndrome (anti-heart attack, trauma, heart failure, kidney

failure), Anti- migraine, anti-hemorrhoids /anti infection, Anti-cancer, Anti-acidity

anti-epileptic /anticonvulsant. Fat soluble molecules, anti-epileptic /anticonvulsant.

The proposed production quantity is 209.47 MT/Month.

III. Need of the Project and its importance to the country and or region

Active pharmaceutical ingredients are the active substances that are used in the

manufacture of a drug and have a pharmacological effect. They provide health

benefits and play a vital role in disease diagnosis, prevention, and treatment. Active

pharmaceutical ingredients may be synthesized either chemically or through

biotechnological methods. They are used in a wide range of therapeutic areas such as

oncology, respiratory disorders, and rheumatoid arthritis.

The analysts forecast the API market in India to grow at a CAGR of 10.76 percent

over the period 2014-2019.

As per the report -Market Entry - Active Pharmaceutical Ingredients (API) Industry in

India: Analysis of Growth, Trends and Progress (2016 - 2021),the API market is

surging due to the increased demand for pharmaceutical drugs, which in turn is driven

by the aging population, rising prevalence of chronic diseases such as cancer,

diabetes, cardiovascular, neurological and infectious diseases. India and China are the

major suppliers of APIs to North America due to their low production capacities,

labor costs and the presence of a large number of global and domestic players. In

order to cut down on expenses and increase profits, companies have begun

outsourcing the creation of APIs to the developing countries in Asia, leading to

growth in the Asian market.


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India became the third largest global generic API merchant market in 2016, with a 7.2

per cent market share as per BMI, Datamonitor, Kemwell Biopharma, Chemical

Pharmaceutical Generic Association, ICRA Report estimates,

pharmanewsprwire.com, DGCI&S.1

India’s API manufacturing industry is 3rd largest in world in terms of volume & 13th

largest in terms of value & is expected to grow at a CAGR of 17% in 2011-2017.

India’s API production has doubled in the last couple of years in generic sector. API

market in India is currently highly fragmented but is expected to become consolidated

in the coming years due to increasing competition.

According to a report by Frost & Sullivan, in the pharmaceutical industry, sourcing of

APIs is now being considered as a crucial part of industry’s strategic plan and India is

one of the top countries from which APIs are sourced. Although in terms of value the

demand for APIs still comes from the United States and Europe, the role of the Asia

Pacific region as an important demography for sourcing of APIs is becoming more

prominent. Another noticeable aspect in the pharmaceutical industry today is the

patent expiry of branded products resulting in expansion of generic sector. As a result

of this the Contract Manufacturing Organizations in countries like India are expected

to witness a strong upsurge in demand of APIs in generics sector.

Inspite of this in the innovation segment, a major portion of the manufacturing

process is still controlled by big pharma and the role of Contract Manufacturing

Organizations is still limited.

Apart from this there are several other challenges faced by the industry as Pricing,

Remaining & Retaining Declining Markets, Transparency in supply chain, Regulatory

issues.

Since there is a need to look at the API market from a sustainable and quality

perspective as well as from a price perspective to exploit its potential to become a

brand, M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd. has come out to develop the

API manufacturing industry at Tarapur. As an individual API manufacturer there is a

need to create a differentiation factor, especially when the market situations are

drastically changing.

1 Indian Brand Equity Foundation www.ibef.org


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M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd. has come out with such

improvements in products and have potential in the market. The Mission of M/s.

Ciron Drugs and Pharmaceuticals Pvt Ltd is to build a world-class pharmaceutical

company through development and deliverance of innovative medicines that can help

to mitigate diseases. To form an international reach through their commitment to

customer satisfaction, comprehensive product range, unflagging attention to quality,

and by building mutually beneficial business relationships. To be an eco-friendly in

all our practices.

The finished goods will be sold in domestic market and would be largely exported to

the Regulated International Market as per demand all over the world. In view of

future market demand, it is the best opportunity which may lead to employment

generation to local youth and economical upliftment of local region.

IV. Demand-Supply Gap

The Indian pharmaceutical industry is the world's third-largest by volume and is likely

to lead the manufacturing sector of India. Several Government and private sector

projects with huge amount of investments have been initiated but could not attend the

speed of development for the need of good quality material. Over the last decade,

there has been a sizeable growth in Pharmaceutical sector both in small, medium and

large-scale units. This has given rise to many small and medium scale units to

manufacture pharmaceutical intermediates. The ever-growing requirements of India,

due to higher population and various diseases indicate the need for the growth of this

industry. Thus, there is a gap in demand and supply. Our efforts of generating

products, by-products, downstream products and recycling - reprocessing are indeed

needed. With multinational pharmaceutical companies enhancing their presence in

India, the long-term prospects of the pharmaceutical industry seem fairly bright.

M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd aims to build a world-class pharmaceutical

company by developing and delivering innovative medicines that help patient mitigate

diseases. To have International reach though our commitment to customer satisfaction,

comprehensive product range, unflagging attention to quality and by building mutually

beneficial business relationships without harming nature. It also intends to maximize API

production in order to cater to Domestic and International markets. These products will

serve to cut the supply of imports from foreign countries thus saving financial


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resources and at the same time will earn valuable foreign currency by export of the

proposed products. The proposed products have high in demand in the export market.

Also, the demand for API and formulations is increasing in the domestic market.

Production of these products domestically reduces the need to import active

pharmaceuticals ingredient in future along with significant scope for export of these

products. The finished goods will be sold in domestic market and as well as largely

exported to the Regulated International Market as per demand across the world. The

proposed products will be manufactured to supply to country's demand and supply to

Africa, Latin America and Southeast Asian markets etc.

V. Imports vs. Indigenous Production

Most of the required raw materials are sourced outside Thane for own formulation

units. The proposed unit at Palghar will help to reduce raw materials requirement of

bulk drugs of Formlations units at Thane .

VI. Export Possibility

CIRON manufactures a wide range of Pharmaceutical formulations at its independent,

state-of- the-art manufacturing facilities, which also house independent quality control

departments and research & development units. The CIRON Group has two fully

automated, state-of- the-art independent production units. The company is expanding

its manufacturing capabilities to meet the growth requirement of the future. Exports

to Africa, Latin America and Southeast Asian markets. CIRON have WHO-GMP and

ISO 9001:2008 certified manufacturing plants manufacturing small volume liquid

injections, lyophilized products, ophthalmic drops, powder injection, liquid oral,

ointment, cream, gels, tablets, capsules, dry syrups.

VII. Employment Generation (Direct & Indirect) due to the project

The total direct employment potential of the industry is about 150 people. However,

there will also be indirect employment generation due to the project during the

transportations, marketing & distribution etc.


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3. Project Description

I. Type of Project

The main activity of the industry is manufacturing of Active Pharmaceutical

Ingredients (APIs).

II. Location of Project

M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd is proposing API manufacturing industry

located at Sr.no. 30, H.no. 6+78/2,6+7+8/4 to 17&6+7+8/19 to 24 village Pam

Tembhi, Taluka Palghar, District Palghar.

Site proximities are presented in below Table No.1.2

Table No.1.2: Site Proximities

Sr.No. Particulars Details

1. Project Location PamTembhi village adjacent to well-developed Tarapur MIDC

area.

2. Geographical

Coordinates

Latitude : 19°48'19.28"N

Longitude : 75°13'42.68"E

3. Access road Navapur road at distance of 0.3km : 6m wide

State highway -74 (Boisar Tarapur road) which is towards

North East direction at an aerial distance of 3.26 km and NH-8

which is towards East of project site at an aerial distance of 20

km away.

4. Nearest City/ Market Boisar 3km

5. Nearest Fire Station Tarapur MIDC Fire Station – 2.16 km

6. Nearest Airport Chhatrapati Shivaji International Airport, Mumbai is at distance

of 80.39 kms

7. Nearest Railway Station Boisar -5 km

8. Water Supply Local Competent Authority

9. Water Body • Banganga river ( aerial distance of 1.82 kms from

project site towards North; aerial distance of 3.24kms

towards South direction)

• Arabian Sea: At an aerial distance of 4.5kms from

project site towards West direction

• Surya River: 13.55kms towards East of project site

• Devkhop Dam (12.82kms towards South East direction)


12

Figure 1.1:-Location map of Project site


13

Plate no.1: Site Photograph


14

Figure no.2: Master Layout plan


15

III. Details of Alternative Sites

3 different alternative sites have been studied before finalizing the final land pocket. Out

of which, option 1 was located in village Pam Tembhi, Taluka Palghar, District Palghar.

Option 2, located in Vikramgadh village, Taluka Thane, District Thane where as option 3

was located in Gowade Village, Taluka Palghar, District Palghar.


16

Figure no.3: Alternative site analysis


17

Before finalizing the proposed site, 3 alternative sites were examined as per

MoEF&CC guidelines and were further studied with respect to various

environmental parameters. The comparative analysis of site is presented in table

no. 2.

Table no. 2 :- Comparative Statement of distance of alternative sites to various

Environmental parameters

Sr.

No

.

Environmenta

l Parameters

Site 1 - Village Pam

Tembhi, Taluka

Palghar, District

Palghar

Site 2 –

Vikramgadh

Taluka Thane,

District Thane

Site 3 – Gowade

Village ,Taluka

Palghar, District

Palghar

1 Land Use of

the proposed

project site.

Non Agricultural Agricultural Agricultural

2 Topography Flat Partially

Undulating

Flat

3 Surrounding

Land Use

Compatibility

Industrial

Development

Agricultural Agricultural

4 Site

Connectivity

a) Approach

road

Paved Road

Kuccha Road

Paved Road

5 Nearest

Habitation

Boisar(aerial

distance 3 km E)

Apti Kh. (aerial

distance 350 m NE)

Pali (1.4 km SE)

Gowade (aerial

distance 0.96kmN)

6 Water Body Surya River: aerial

distance 13.55kms

towards East of

project site

Banganga River

aerial distance 1.82

kms from project site

towards North; and

3.24kms towards

South direction

Devkhop Dam ,

Nandore (aerial

distance 12.82 kms

towards South East

direction)

Pinjaal River

(aerial distance 1.8

km SE)

Vaitarna River

(4.57 km S)

Surya River (aerial

distance 1.85 km W)

Vaitarna River

(3.68km E)

Dukhtan Dam

(1.52km SE)

7 Notified

Critically

Polluted Area

as per CPCB

within 5 km

radius

None None None


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Sr.

No

.

Environmenta

l Parameters


Tembhi, Taluka

Palghar, District

Palghar

Site 2 –

Vikramgadh

Taluka Thane,

District Thane

Site 3 – Gowade

Village ,Taluka

Palghar, District

Palghar

8 Archeological

Monuments

within 7 km

radius

None None None

9 Reserved

Forest/

Protected

forest within

10 km radius

RF near Saye (aerial

distance 17.81 km E)

RF near Indgaon


km W)

RF near Pali (aerial

distance 0.3 km E)

RF near Indgaon


km W)

RF near Pali (aerial

distance 0.3 km E)

10 Ecological

sensitive area

(Wildlife

Sanctuary,

Core

Biosphere

Reserve,

National Park

etc) within 5

km radius None None None

11 Land

Acquisition

and R&R

Study

Land is under

possession of the

proponent , R & R is

not applicable.

Land not in

possession hence R

& R not

applicable.

Land not in

possession hence R

& R not applicable.

12 Airport Chhatrapati Shivaji

International Airport,

Mumbai is at aerial

distance of 80.39

kms

towards South of site

Chhatrapati Shivaji

International

Airport is at aerial

distance of 77.3 km

towards South of

the project site Daman ( 70 km N)

Chhatrapati Shivaji

International Airport,

Mumbai is at

distance of 87 kms

towards South of site

13 Railway

Station

Boisar Railway

Station

(aerial distance 5 km

W)

Palghar Station

(aerial distance 13

km SW)

Umroli Railway

Station (aerial

distance 6.03 km SE)

Boisar Railway

Station (aerial

distance 15 km W) Palghar Station

(aerial distance 13

km SW)

Boisar Railway

Station (aerial

distance 16 km W)

Umroli Railway

Station

(aerial distance

12.96kms NW)

Palghar Station

( 10km SW)

14 National

Highway &

State Highway

NH 8 (aerial distance

20.90 km E)

SH 74 (aerial

distance 3.26 km

NE)

NH 8 (aerial

distance 15 km W)

SH 35 (aerial

distance 1.4 km S)

NH 8 (aerial distance

8.58 km NE)

SH 73 (aerial

distance 8.28 km E)

15 Market

demand and

availability of

end consumers

Boisar (aerial

distance 3.41 km

NW)

Palghar (aerial

Boisar (aerial

distance 36.7 km

NW)

Palghar (aerial

Boisar (aerial

distance 16.72 km

NW)

Palghar (aerial


19

Sr.

No

.

Environmenta

l Parameters


Tembhi, Taluka

Palghar, District

Palghar

Site 2 –

Vikramgadh

Taluka Thane,

District Thane

Site 3 – Gowade

Village ,Taluka

Palghar, District

Palghar

distance 12.41 km

W)

Mumbai (aerial

distance 81.62 km S)

Vapi (aerial distance

64.77 km N)

distance 32.7 km

W)

Mumbai (aerial

distance 70.1 km

SW)

Vapi (aerial

distance 77.9 km

N)

distance 11.03 km

W)

Mumbai (aerial

distance 70.1 km

SW)

Vapi (aerial distance

67.65 km N)

Proposed project is located adjacent to Tarapur MIDC. Site has been finalized on

the basis of following merits

• Site is adjoined to well-developed Tarapur MIDC, hence all required

infrastructure likes tar roads, electricity , water and other facilities are

already developed around the project. In addition to that site is accessible

from Navapur Road, State highway -74 (Boisar Tarapur road) at an aerial

distance of 3.26 km and National Highway -8 (NH-8), 20 km away.

• The proposed site is surrounded by industrial land use consisting of

industries such as Ms. Nandolia Organic Chemicals Pvt Ltd., Lupin Ltd.,

JPN Pharma Pvt., Aarti Industries., etc. thereby ensuring surrounding land

use compatibility.

IV. Size or Magnitude of operation

The proposed industry will manufacture 107 nos. of products with the

production quantity 209.47MT/month (2513.64 TPY).Details of proposed

production are presented below table

Table 2.1: Product Details

Sr.no. Name of the

products CAS No

Category of product/Therapeutic

Use

Propo

sed

Produ

ction

Quan

tity

MT/

M

Propo

sed

Produ

ction

Quan

tity

MT/A

1 Clopidrogel 135046-48- Antithrombotic 0.3 3.6


20

hydrogen

sulpfate

9

2 Carvedilol 72956-09-3 Antihypertensive 0.3 3.6

3 Fexafenadine

Hydrochloride

153439-40-

8 Antihistamine 3 36

4 Finasteride 98319-26-7 (BPH)/ (DHT) Benign Prostatic

Hyperplasia (BPH) 0.3 3.6

5 Ketorolac

Tromethamine

74103-07-

4 Anti-Inflammatery 2 24

6 Metformin

hydrochloride 1115-70-4. Anti-Diabetic 15 180

7

Neostigmine

Methylsulfate

/Bromide

51-60-5 /

114-80-7. Anticholinesterase 0.2 2.4

8 Paracetamol 103-90-2 Analgesics. 5 60

9 Phytomenadio

ne 84-80-0 Anticonvulsant. 0.5 6

10 Voriconazole 137234-62-

9 Anti-Fungal 0.2 2.4

11 Hydrocortisone

sod succinate 125-04-2 Antihistaminic 0.3 3.6

12

Methyl

prednisolone

sod succinate

2375-03-3 Antihistaminic 0.3 3.6

13

Methyl

prednisolone

acetate

53-36-1 Antispasmodics 0.3 3.6

14 Adrenaline 51-43-4 Antihistaminic 0.3 3.6

15 Nor adrenaline 51-41-2 Anti-Hypotension 0.3 3.6

16

Dexamethason

e sod

phosphate

micronised

2392-39-4 Antihistaminic 0.3 3.6

17 Carboprost 58551-69-2 Anti- Migraine/ Anti-Postpartum. 0.3 3.6

18

Succinyl

choline

chloride

71-27-2 Antispasmodics 0.3 3.6

19

Phenobarbiton

e and

phenobarbitone

sod

57-30-7 Anti-Psychotic 0.3 3.6

20 Midazolam 59467-70-8 Anticonvulsant / Antiepileptic Drug 0.3 3.6

21 Lignocaine 137-58-6 Anticonvulsant / Antiepileptic Drug 0.3 3.6

22 Bupivacaine 2180-92-9 Anticonvulsant / Antiepileptic Drug 0.3 3.6


21

23 Latanoprost 130209-82-

4

Anti -Glaucoma /Anti-

Ocular Hypertension. 0.3 3.6

24 Bimatoprost 155206-00-

1



25 Brimonidine 59803-98-4 Anti -Glaucoma /Anti-


26 Travatoprost 157283-68-

6



27 Timolol 26839-75-8 Anti -Glaucoma /Anti-


28 Dozolamide 130693-82-

2



29 Omeprazole 73590-58-6 Anti-Acidity 0.3 3.6

30 Pantaprazole 102625-70-

7 Anti-GERD /Anti-Acidity 0.3 3.6

31 Pabeprazole 117976-89-

3 Anti-Acidity 0.3 3.6

32 Ketoprofen 22071-15-4 Anti-Inflammatery 0.3 3.6

33 Dexketoprofen 156604-79-

4 Anti-Inflammatery 0.3 3.6

34 Tramadol 27203-92-5 Analgesics. 0.3 3.6

35 Phenytoin 57-41-0 Anticonvulsant / Antiepileptic Drug 0.3 3.6

36 Fosphenytoin 93390-81-9 Anticonvulsant. 0.3 3.6

37 Artesunate 88495-63-0 Antimalarial 0.3 3.6

38 Oxytocin 50-56-6 Antihistaminic 0.3 3.6

39 Voriconazole 137234-62-

9 Antifungal 0.3 3.6

40 Amphotericin 1397-89-3 Antifungal/ Antibiotics 0.3 3.6

41 Ganciclovir 82410-32-0 Anti-Viral 0.3 3.6

42 Alprostadil 745-65-3 Anti- Erectile Dysfunction

(Impotence) 0.3 3.6


22

43 Hydralazine

HCL 304-20-1 Antihypertensive 0.3 3.6

44 Vecuronium

bromide 50700-72-6 Anticonvulsant 0.3 3.6

45 Rocuronium

bromide

119302-91-

9 Anticonvulsant 0.3 3.6

46 Vancomycin

HCL 1404-93-9 Antibiotic 0.3 3.6

47

Chloramphenic

ol sod

succinate

982-57-0 Antibiotic 0.3 3.6

48 Clindamycin 18323-44-9 Antibiotic 0.3 3.6

49 Aciclovir

sodium 69657-51-8 Anti-Shingles Infection. 0.3 3.6

50 Adrenaline 0.3 3.6

51

Alpha

Linolenic acid

(ALA)

463-40-1 Anti- Cancer. 0.3 3.6

52

Amino Acid all

types (L-

SERIES)

Build Proteins And Proteins Are

Life-Sustaining Macronutrients. 1 12

53 Arteether 75887-54-6 Anti-Malarial 2 24

54 Artemether 71963-77-4 Anti-Malarial 2 24

55 Atracuronium

Bromide Anticholinesterase/ Anticonvulsant 0.3 3.6

56 Brinzolomide 138890-62-

7



57 Canagliflozin 842133-18-

0 Anti-Diabetic 0.3 3.6

58 Capreomycin

Sulphate 1405-37-4 Antibiotic 5 60

59

Ciprofloxacin

HCL

Monohydrate

86393-32-

0 Anti-Infection 36 432

60 Clonidine HCL 4205-91-8 Antihypertensive 0.3 3.6

61 Colistin

Sulphate 1264-72-8 Anti-Infection 1 12

62 Dapagliflozin 461432-

26-8. Anti-Diabetic 0.3 3.6

63 Dobutamine 34368-04-2 Anti-Congestive Heart Failure/Anti-

Increase Cardiac Output. 0.2 2.4


23

64 Dopamine

Hydrochloride 62-31-7

Anti-Shock Syndrome (Anti-Heart

Attack, Trauma ,Heart

Failure,Kidney Failure)

0.5 6

65 Dorzolamide

HCL

130693-82-

2



66

Esomeprazole

magnesium

dihydrate

217087-

10-0 Anti-Tussive 2 24

67 Fentanyl

citrate 990-73-8 Anti- Migraine 0.2 2.4

68 Ferrous

Ascorbate

24808-52-

4. Anti-Anemia 3 36

69 Fluphenzine

Deconate 5002-47-1 Antipsychotic 0.1 1.2

70 Flurbiprofen 5104-49-4 Analgesics. 0.67 8.04

71 Glucose 50-99-7. Anti Hypoglycemia 10 120

72 Glycofurol 31692-85-

0 Intramuscular Injection. 1 12

73 Granisetron

HCL

107007-

99-8. Antiemetic 0.2 2.4

74 Haloperidol

Decanoate 74050-97-8 Antipsychotic 0.1 1.2

75 hydralazine

HCL 304-20-1 Antihypertensive 0.5 6

76 Hydrocortisone

Acetate 50-03-3 Anti-Hemorrhoids /Anti Infection 0.5 6

77 Ibandronate

sodium

138844-

81-2. Anti Osteoporosis 0.3 3.6

78 Ibuprofen 15687-27-1 Anti-Inflammatery 50 600

79 Indomethacin 53-86-1 Anti-Inflammatery 1 12

80 iohexol/iopami

dol/iodixanol

66108-95-

0./ 60166-

93-0/

92339-11-2

Radiologic (X-Ray) Examination. 1 12

81 ipratropium

bromide 22254-24-6

Antiallergies/Antichronic

Obstructive Pulmonary Disease

(COPD)

0.3 3.6

82 Irbesartan 138402-11-

6 Antihypertensive 0.3 3.6


24

83 Isoprenaline 7683-59-2 Anti-Bradycardia/Anti Asthma. 0.2 2.4

84 Ketoprofen 22071-15-4 Anti-Inflammatery 2 24

85 Lidocaine base

or lidocaine 137-58-6 Antiarrhythmic 10 120

86 Lumefantrine 82186-77-4 Anti- Malaria. 10 120

87 Lysine

Salicylate 59535-08-9 Anti-Inflammatery 1 12

88 Methocarbamo

l 532-03-6 Antispasmodics 5 60

89

Metoprolol

Sucicnate

/Tartrate

98418474/

56392-17-7 Antihypertensive 1 12

90 Midazolam 59467-70-8 Anticonvulsant 1.2 14.4

91 Natamycin 7681-93-8 Anti-Fungal . 0.2 2.4

92 Noradrenaline

Bitartrate

108341-18-

0. Antihypotensive 0.5 6

93 Pamidronic

Acid 40391-99-9 Anti-Cancer 0.5 6

94 Pancuronium

Bromide 15500-66-0 Antiepileptic 0.1 1.2

95 Pantaprazole 102625-70-

7 Anti-Acidity 1 12

96 Phenytoin

sodium 630-93-3 Anticonvulsant. 2 24

97

Phophatidylch

olineHydrogen

ated

Anti-Cancer. 1 12

98 Prednisolone

Acetate 52-21-1 Anti-Inflammatery 0.5 6

99 pregabalin 148553-50-

8 Anti-Epileptic /Anticonvulsant. 0.5 6

100 Quetiapine

fumerate

111974-72-

2. Antipsychotic 1 12

101 Rabeprazole

sodium

117976-90-

6 Antibiotics 1 12

102 Residronate Na 115436-72-

1 Anti-Paget's Disease. 0.3 3.6

103 Rocuronium

Bromide

119302-91-

9 Anticonvulsant. 0.1 1.2

104 Soya Lecithin

Powder 8030-76-0. Fat Soluble Molecules 10 120

105 Valacyclovir 124832-26-

4 Anti-Varicella Zoster/Anti-Virus 0.2 2.4

106 Vecuronium

Bromide 50700-72-6 Anticonvulsant. 0.2 2.4

107 Voglibose 83480-29-

9. Anti-Diabetic 0.2 2.4


25

Pharmaceutical molecules is variable and unit cannot produce all the molecules at a

time. Production quantity of drugs may vary according to market demand but the total

proposed production will not exceed the production limit as mention above.


26

V. Project Description with process details

Product Name: Clopidogrel Hydrogen Sulfate

CAS No.: 135046-48-9

Stage-1: Preparation of Clopidogrel Hydrogen Sulfate

2-thiopene-2-2yl ethanol3.6 kg

4-Methyl benzene sulfonyl

chloride 5.36kg

Toluene =25.2kg

Triethylamine=2.88kg

Water =96kg

ETP 96.24kg

Reactor

Reaction Mass at 55°C

to 60°C)

Reactor

( Layer Separation)

Reactor

(Charging at 25°C to

30°C)

Reactor

( Stirring for 3 hour cool

at 15°C to 20°C)

Reactor

(Stirring for 5 hour at

40°C to 45°C)


27

Triethylamine Hydrochloride3.6kg

Toluene Recovery24kg

Toluene loss1.13kg

Toluene ML for Recovery

Toluene 5 kg

Stage-I Compound =8kg

(7.93+0.0688)


Reactor

Distillation

Filtration

&Centrifuged 2hr


30°C)

Drying

at 60°C to 65°C)


28


29

Ethyl Acetate 2 kg

Stage -3 Compound =9.2kg



Stage-3 with Cyclohexane5.6 kg

(5.464+0.136)

Stage-1 with Toluene 8 kg

(7.93+0.068)

Ethyl Acetate 30kg

Hydrochloric Acid (35%)3.44 kg

Water120 kg

Aqueous layer

forETP122.44kg

Recovery Ethyl Acetate

31.33kg

Ethyl Acetate loss

1.28kg

Reactor


30°C)

Reactor

(Stirring at 45°C to

50°C)

Reactor


30°C)

Reactor

(Stir for 60 minute at

45°C to 50°C)

Reactor


50°C)

Reactor

(Distillation at 65°C

to 75°C)

Centrifuge / Nutche

Filter

(Filtration at 25°C to

30°C)

Reactor


50°C)

Aqueous layer for ETP

122.44kg

Recovery Ethyl Acetate 31.33kg

Ethyl Acetate loss 1.28kg

Ethyl Acetate Ml for Recovery.

TD/VTD

(Drying at 60°C to

65°C)


30


Stage-3=9.3kg

Formaldehyde(40%) 4kg

Acetone 40kg

SodiumHydroxide3.2kg

Sulfuric Acid 6kg

Reactor


30°C)

Reactor

(stirring for 6 at 35°C to 40°C)

Reactor


30°C)

Reactor

(Stirring for 3hr at

40°C to 45°C)

Reactor (Charging at 40°C to

45°C)

Reactor

(Stirring for 3hr at 15°C to

25°C)

Cool and Digestion


31


32

Product Name: Carvedilol

CAS No.: 72956-09-3

Stage-1: Preparation of Carvedilol

Phenyl hydrozine Hydrochloride

5kg

Toluene 50

1,3-Cyclohexadione 4.21kg

Sodium Hydroxide 1.57kg

Water 30kg Aqueous layer

Effluent 30 kg

Toluene 5 kg Toluene Ml for

Recovery

Toluene for Recovery

48.450kg

Toluene loss 1 kg

Reactor

(Stirr for 12 hour at 45°C to

50°C)

Reactor


30°C)

Reactor


50°C)

Nutche Filter

(Hyflo at 25°C to 30°C)

Reactor

(Distillation at 65°C to

70°C)

Reactor

(Layer Separation)


33

Isopropyl Alchol 15 kg

Isopropyl

AlcoholeRecovery14.25 kg

Isopropyl Alcohol loss =0.40kg

Organic Residue 1.15kg

Process

Isopropyl Alchole20kg Isopropyl Alchole ML for

recovery

Organic Impurities

Stage-I Compound =6.650kg

Centrifuge / Nutche Filter

(Filtration at 5°C to 10°C)

Reactor

(Distillation for

at 105°C to

120°C)

TD / VTD

(Drying at 60°C to 65°C)

Reactor

(Charging for 2 hour at

25°C to 30°C)

Reactor

(Stirr for 12 hour at

45°C to 50°C)


34


Stage-I 6.650 kg

Water 35 kg

Sulfuric Acid 1.750kg

Water 50kg Aqueous layer for ETP 37.40kg

Water =10kg Pharma ML for storage tank for

reused

Reactor

(Stirr for 12 hour at

15°C to 25°C)

Reactor

(Stir for 12 hour at

45°C to 50°C)

Reactor

Digestion and cool

15 °C to25 °C)

Centrifuge / Nutche

Filter


10°C)

TD / VTD


Reactor

(Layer

Separation)

Reactor


25°C to 30°C)

Reactor


55°C to 60°C)


35

Stage-II Compound =6.315kg

Stage-3: Preparation of Carvediol

Stage-II compound 6kg

Methanol 30kg

Palladium carbon 05 kg

Hyflo 0.750kg

Hyflo 0.750kg

Methanol 5kg

carbon 0.500kgsolid waste

Methanol for Recovery for 28.5kg

Methanol loss 900kg

Reactor

(Charging at 25°C to 30°C)

Reactor

(Stirring at 35°C to 40°C)

Reactor


Reactor

(Stir for 2hrs at 45°C to

50°C)

Nutche Filter

(Hyflo at 25°C to 30°C)

Reactor

(Distillation at

60°C to 65°C)


36

Water 30 kg

For ETP 31.485kg

Stage-3 Compound=5.100kg


Stage-3 Compound 5.100 kg

Toluene 50 kg

Epichlohydrine 2.9kg

Centrifuge / Nutche Filter

(Filtration at 25°C to 30°C)

Reactor


50°C)

Reactor


40°C)

Reactor

(Stir 60 minute at

45°C to 50°C)

TD/VTD


Reactor

(Stir 60 minute at

45°C to 50°C)

Reactor


Reactor

Layer separation


37

Water 30kg

Aqueous layer for ETP31.48kg

Toluene for

Recovery48.450 kg

Toluene loss 1 kg

Methanol 25 kg

Methanol ML for

Recovery19kg

Methanol loss 0.60kg

Reactor

(Layer separation)

Reactor


to 65°C)

Reactor


Reactor

(Stir 60 minute at 45°C

to 50°C)

Reactor


to 65°C)

Reactor


40°C)


38

Methanol 5 kg Methanol loss0.600kg

Methanol ML for

Recovery19kg

Stage-4 Compound =6 kg

Stage-5: Preparation of Corvedilol

2- Methoxy Phenol 3.57kg

Toluene 34kg

Chloroacetonitrile 2.210kg


Centrifuge / Nutche

Filter


30°C)

TD/VTD


Reactor


30°C)

Reactor


40°C)

Reactor


25°C)

Reactor

(Stir 60 minute at

45°C to 50°C)


39

Toluene Recovery

32.975kg

Toluene loss 0.675kg

Organic

Residue0.919kg

Water 30kg

Aqueous for ETP

32.256kg

Methanol 30 kg

Methanol Recovery

12.65kg

Methanol loss

0.675kg

Reactor


25°C)

Reactor


65°C)

Reactor (Charging at

20°C to 25°C)

separation

Reactor (Distillation at

75°C to 80°C)

Reactor

Layer separation

Reactor

(Stirr at 20°C to 25°C)


40

Methanol5kg

Organic Impurities

0.21kg

Methanol ML for

recovery

Stage-5 Compound =4.250kg


Stage-5 compound 4.250kg

Methanol 20kg

Palladium Carbon 0.350kg

Hyflo0.526kg

Centrifuge / Nutche

Filter


30°C)

TD/VTD


Reactor

(Stir at 20°C to 25°C)

Reactor


25°C)

Reactor

(Stir at 20°C to 25°C)

Reactor


25°C)


41

Methanol 3.50kg Hflo for

solid waste

0.526 kg

Methanol recovery

19kg

Methanol loss

0.600kg

Hydrogen0.150kg Process

Emission0.046kg

Organic

impurities0.11kg

Methanol 5kg Methanol ML for

Recovery


Reactor

(Charging at 20°C

to 25°C)

Reactor


65°C)

TD/VTD


Reactor

(Digestion at 20°C to

25°C)

Centrifuge / Nutche

Filter


30°C)

Nutche Filter

(Hyflo at 25°C to

30°C)


42


Stage -4 = 6.kg

Stage -6 = 4.25 kg

Toluene =30kg

Water 40kg

ETP

40.350kg

Toluene 10kg

Toluene Recovery

39.100kg

Toluene loss

0.800kg

Reactor


25°C)

Reactor


25°C)

Reactor

(Layer Separation)

Reactor


25°C)

Reactor


50°C)

Reactor


115°C)

Reactor

(Stirring for 3 at 50°C to

60°C)


43

Centrifuge / Nutche

Filter


30°C)

Toluene Ml for Recovery

Toluene 5kg

Carvedilol (Pure)= 10 kg

Product Name : Carvedilol

CAS NO.: 72956-09-3


INPUT

No.

of

moles

Mol.Wt.

OUTPUT

No.

of

moles

Mol. Wt.

Phenyl hydrozine Hydrochloride 1 144.50

3-(phenyl

Hydrazono)cyclohexone 1 202.00

1,3-Cyclohexanedione 1 112.00

Sodium Chloride 1 58.50

Sodium Hydroxide 1 40.00

Water 2 36.00

TD/VTD

(Drying at 60°C to

65°C)


44

Total Input = 296.50

Total Output = 296.50

Material Balance:

INPUT Kg

OUTPUT Kg

Product

Phenyl hydrozine Hydrochloride = 5.000 Stage-1 = 6.650

Recovery

1,3-Cyclohexanedione = 4.000

Toluene = 48.450

Sodium Hydroxide = 1.500

Toluene loss = 1.000

Tolunene = 50.000

Isopropyl Alcohol = 14.250

Isopropy Alcohole = 15.000

Isopropyl Alcohol loss = 0.450

Water = 30.000

Aqueous

Effluent = 31.460

Organic Compound

=0.0395

1,3-

Cyclohexandione=0.125

Toluene=0.05

Gen.Water= 1.24

Water=30

Organic Residue

= 1.100

Organic Impurities=0.315

Toluene=0.52

Isopropyl Alcohol=0.315

Inorganci Solid waste = 2.14

Sodium Chloride =2.13

Sodium

Hydroxide=0.1221





45

Stage -: 2

Mole Balance:

INPUT

No.

of

mole

s

Mol.Wt

. OUTPUT

No.

of

mole

s

Mol. Wt.

3-(phenyl

hydrazono)Cyclohexanone 1 202.000

4-oxo-1,2,3,4-

Terahydrocarbazole 1 185.000

Sulfuric Acid ½ 49.000

Ammonium sulfate ½ 66.000



Material Balance:

INPUT Kg

OUTPUT Kg

Product

Stage-1 =

6.650

Stage-2 = 6.000

Sulfuric Acid = 1.750

Aqueous

Water = 35.000

Effluent

37.400

Ammonium sulfate =2.28

Sufuric Acid=0.144

Organic Compound

=0.095

Water=36.842





46

Mole Balance:

INPUT

No.

of

mole

s

Mol.Wt

. OUTPUT

No.

of

mole

s

Mol. Wt.

4-oxo-1,2,3,4-

Terahydrocarazole 1 185.00

4-Hydroxy Carazole 1 183.00

Hydrogen 1 2.00



Material Balance:

INPUT Kg

OUTPUT Kg

Product

stage-2 = 6.000 Stage-3 = 5.100

Recovery

Palladium Carbon = 0.500

Methanol = 28.500

Water = 30.000

Methanol loss = 0.900

Methanol = 30.000


Hyflo = 0.750

Aqueous

Effluent

31.485

Organic Compound

=0.135

Methanol=0.6

Water =30

Organic Residue

= 0.7



47

Inorganic Solid waste

Hyflo=0.75

Process Emissions

0.065

Hydrogen=0.065




Mole Balance:

INPUT

No.

of

mole

s

Mol.Wt

. OUTPUT

No.

of

mole

s

Mol. Wt.

4-Hydroxy Carbazole 1 183.00

4-(2,3-Epoxy propxy)

Carbazole 1 239.00

Epichlorohydrin 1 92.50



Water 1 18.00


48



Material Balance:

INPUT Kg

OUTPUT Kg

Product

Stage-3 = 5.100 Stage-4 = 6.000

Recovery

Epichlorohydrin = 2.900

Toluene = 48.450



Tolunene = 50.000

Methanol = 19.000

Methanol = 20.000


Water = 30.000

Aqueous

Effluent = 32.318


Sodium Hydroxide=0.135

Toluene=0.05

Gen.Water= 0.501

Water=30

Organic Residue

= 1.882


Methanol=0.4

Toluene=0.5

Epichlorhdrin=0.322





49

Mole Balance:

INPUT

No.

of

mole

s

Mol.Wt

. OUTPUT

No.

of

mole

s

Mol. Wt.

2-Methoxy phenol 1 124.00

2-(2-Methoxyl

phenoxy)acetonitrite 1 163.00

Chloroacetonitrite 1 75.50



Water 1 18.00



Material Balance:


50

INPUT Kg

OUTPUT Kg

Product

2-Methoxy phenol = 3.400 Stage-5 = 4.250

Recovery

Chloroacetonitrite = 2.210

Toluene = 32.975



Tolunene = 34.000

Methanol = 12.650

Methanol = 13.600


Water = 30.000

Aqueous

Effluent = 32.256


Sodium Hydroxide=0.093

Chloroacetonitrile=0.016

Toluene=0.05

Gen.Water= 0.493

Water=30

Organic Residue

0.919

Organic Impurities

=0.219

Toluene=0.3

Chloroacetonitrile=0.124

Methanoll=0.275




Mole Balance:


51

INPUT

No.

of

mole

s

Mol.Wt

. OUTPUT

No.

of

mole

s

Mol. Wt.

2-2(Methoxyphenoxy

Acetonitrite 1 163.00

2-(2-Methoxyl phenoxy)

ethylamine 1 167.00

Hydrogen 2 4.00



Material Balance:

INPUT Kg

OUTPUT Kg

Product

Stage-5 = 4.250 Stage-6 = 4.250

Recovery

Hydrogen = 0.150

Methanol = 19.000




Aqueous

Hyflo = 0.500

Effluent = 30.50

Methanol = 20.000

Methanol=0.4

Water = 30.000

Organic Compound =0.11

Water=30

Inorganic Solid waste = 0.500

Hyflo=0.5

Process Emissions = 0.046

Hydrogen=0.047





52

Mole Balance:

INPUT

No.

of

mole

s

Mol.Wt

. OUTPUT

No.

of

mole

s

Mol. Wt.

4-(2-3-Epoxy propoxy)

Carbazole 1 239.00

Carvedilol 1 406.00

2-(2-Methoxy phenoxy)

ethyamine 1 167.00



Material Balance:

INPUT Kg

OUTPUT

Kg


53

Product

Stage-4 = 6.000 Carvedilol = 10.000

Recovery

Stage-6 = 4.250

Toluene = 39.100

Toluene = 40.000


Water = 40.000

Aqueous

Effluent = 40.350

Organic Compound =0.25

Toluene=0.1

Water=40



Product Name: Fexofenadine Hydrochloride

CAS No.: 153439-40-8 Stage-1: Preparation of Fexofenadine Hydrochloride

4-(4-Chloro-1-oxobutyl)

,α,ɑ-Dimethyl phenyl acetate

91kg

Azacyclonol 86 kg

Ethyl Acetate 300kg

Potassium Bi-carbonate 50kg

Potassium Iodide 5 kg

Water 910kg Effluent 971kg

Reactor

Digestion for 5 hour

at 20°C to 25°C)

Reactor


30°C)

Reactor


Reactor

(Layer Separation)


54

Methanol 300 kg

Methanol Recovery 279kg

Methanol loss 15kg

Methyl Isobutyl Ketone

385 kg

Ethyl Acetate 279 kg

Methanol0kg Methanol ML for

recovery

Organic Impurities

Centrifuge / Nutche

Filter


10°C)

Reactor


40°C to 45°C)

Reactor


to 70°C)

TD / VTD

(Drying at 60°C to

65°C)

Reactor

(Charging for 2 hour

at 25°C to 30°C)

Reactor

(Charging for 5hour

at 25°C to 30°C)

Reactor

(Stir for 12 hour at 45°C

to 50°C)

Reactor

(Distillation at 75°C to 90°C)


55


Stage-2: Preparation of Fexofenadine Hydrochloride

Stage-I Compound 155kg

Methanol 500kg

Sodium Borohydride 7kg

Sodium Hydroxide 13kg

Acetic Acid 5kg

Reactor


30°C)

Reactor

Layer separation

Reactor


45°C to 50°C)

Reactor

(Stir for 5hour at

45°C to 50°C)

Reactor

(Stir for 7 hour at

65°C to 70°C)

Reactor


30°C)


56

Water 1550kg Aqueous layer for ETP

1550kg

Methanol Recovery

465kg

Methanol loss 25kg

Organic Residue

14.320kg

Methanol 25 kg Methanol Ml for

Recovery

Stage-II Compound =136kg


Stage-II compound 136kg

Sodium hydroxide Flakes

40kg

Ethanol 500 kg

Reactor


30°C)

Reactor


40°C)

Reactor


to 90°C)

TD / VTD

(Drying at 60°C to

65°C)

Centrifuge / Nutche

Filter


10°C)


57

Hydrochloric Acid 140kg

Ethyl Acetate 250 kg waste 8.300 kg

Ethanol recovery

465kg

Ethanol loss

25kg

Water 1900 kg Aqueous layer for

ETP 2086.5kg

Activated Carbon 7 kg

Hyflo 5kg

Reactor


65°C to 70°C)

Reactor


40°C)

Reactor


to 80°C)

Reactor

(Layer Separation)

Reactor


40°C)

Reactor


50°C)

Reactor


65°C to 70°C)


58

Ethyl Acetate 50kg Hyflo for solid

waste 5kg

Carbon 7 kg

Ethanol 250kg

Ethyl Acetate recovery

465kg

Ethyl Acetate

loss 25kg

Ethyl Acetate 50kg Ethyl Acetate ML

for recovery

Stage-3 Compound =118kg

Reactor


50°C)

Nuthc Filter

(Hyflo Filtration at

25°C to 30°C)

Centrifuge / Nutche

Filter


30°C)

TD/VTD

(Drying at 60°C to

65°C)

Reactor


to 65°C)

Reactor

(Stir 60 minute at 45°C

to 50°C)


59


Stage-3 Compound 118kg

Acetone 300 kg

Activated Carbon 5kg

Hyflo 5 kg

Hyflo for solid

waste5kg

Acetone 50 kg Carbon 5kg

Organic

Residue 28kg

Acetone Recovery

465kg

Acetone loss 25kg

Reactor


30°C)

Reactor

(stirring at 25°C to

30°C)

Reactor


70°C)

Reactor

(stirring for 60 min at

25°C to 30°C)

Reactor


80°C)

Nutche Filter

(Hyflo Filtration at 25

°C to 30 °C)


60

Acetone 200 kg

Acetone 50kg Organic Impurities

18kg

Acetone ml for

recovery

Fexofenadine Hydrochloride =100kg

Product Name: Fexofenadine Hydrochloride

CAS NO.:153439-40-8


Centrifuge / Nutche

Filter


30°C)

TD/VTD

(Drying at 60°C to

65°C)

Reactor


30°C)

Reactor

(stirring for 60 min at

25°C to 30°C)


61

Stage-1: Preparation of Fexofenadine Hydrochloride Mole Balance:

INPUT

No.

of

moles

Mol.Wt.

OUTPUT

No.

of

moles

Mol. Wt.

4-(4-Chloro-1-Oxobutyl)-α,α-

dimethyl phenyl acetate 1 282.50

Stage-1-Compound

549.50

Azacyclonol 1 267.00



Material Balance:

INPUT Kg

OUTPUT Kg

Product

4-(4-Chloro-1-Oxobutyl)-α,α-

dimethyl phenyl acetate = 91.000

Stage-1 = 155.000

Recovery

Methanol = 279.000

Azacyclonol = 86.000


Methyl Isobutyl Ketone = 385.000

Ethyl Acetate = 279.000

Methanol = 300.000

Ethyl Acetate loss = 15.000


62



Potassium Iodide = 5.000


Potassium Bicarbonate = 50.000

Water = 910.000

Aqueous

Effluent = 971.000

Methanol 6

Potassium Bicarbonate 50

Potassium Iodide 5

Water 910

Organic Residue = 36.000

Organic Impurities 22

Methyl Isobutyl Ketone 7.5

Ethyl Acetate 6




Stage -: 2


63

Mole Balance:

INPUT

No. of

moles Mol.Wt.

OUTPUT

No. of

moles Mol. Wt.

Stage-1 Compound 4 2198.00

Stage-2-Compound 4 2060.00

Sodium Borohydride 1 38.00

Sodium chloride 4 234.00

soduim Hydroxide 4 160.00

Boric Acid 1 62.00

Acetic acid 1 60.00

sodium Acetate 1 82.00

water 1 18.00



Material Balance:

INPUT Kg

OUTPUT Kg

Product

Stage-1 Compound =

155.000

Stage-2 = 136.000

Methanol 500.000

Recovery

soduim Hydroxide = 13.000

Methanol = 465.000

Sodium Borohydride = 7.000


Acetic acid = 5.000

Water = 1550.000

Aqueous

Effluent = 1588.815

Methanol 5

Boric Acid 4.37

Sodium Hydroxide 1.2

sodium Acetate 6.835

Sodium chloride 16.5

sodium Metaborate 7.505

Gen.Water 1.5

Water 1546


Organic Residue 9.27

Methanol 5

Process Emissions = 0.915

Hydrogen 0.925




64


Stage -: 3

Mole Balance:

INPUT

No. of

moles Mol.Wt.

OUTPUT

No. of

moles Mol. Wt.

Stage-2 Compound 1 515.00

Fexofenadine Hydrochloride 1 537.50

sodium Hydroxide 1 40.00

Sodium chloride 1 58.50

Hydrochloric Acid 2 73.00

Methanol 1 32.00



Material Balance:

INPUT Kg

OUTPUT Kg

Product


65

Stage- 2 =

136.000

Fexofenadine Hydrochloride

(Crude) = 118.000

Recovery

Ethanol = 500.000

Ethanol = 465.000

soduim Hydroxide Flakes = 40.000

Ethanol loss = 25.000

Water = 1900.000


Activated Carbon = 7.000

Ethyl Acetate loss = 25.000


Hydrochloric Acid (35%) = 140.000

HyFlo = 5.000

Aqueous

Effluent = 2086.500

Ethanol 10

Ethyl Acetate 2.5

Sodium chloride 58.5

Methanol 8.45

Hydrochloric Acid 2.86

Water from Hydrochloric

Acid 91

gen.Water 0.4

Water 1900


Organic Impurities 23.94

Ethyl Acetate 7.5

Spent Carbon = 12.000

Hyflo 5

Carbon 7





66

Mole Balance:

INPUT No. of

moles Mol.Wt.

OUTPUT

No. of

moles Mol. Wt.

Fexofenadine Hydrochloride (Crude)

1 538.12


(Pure) 1 538.12



Material Balance:

INPUT Kg

OUTPUT Kg

Product

Fexofenadine Hydrochloride (Crude) = 118.000


(Pure) = 100.000

Recovery

Acetone = 500.000

Acetone = 465.000

Activated Carbon = 5.000

Acetone loss = 25.000

HyFlo = 5.000


Organic Impurities 18

Acetone 10

Spent Carbon = 10

Carbon 5

Hyflo 5




67

Product Name: Finasteride

CAS No.: 98319-26-7

Stage-1: Preparation of Finasteride

16 DAP 16.70 kg

Methanol 83.34 kg

Palladium Carbon 1.67kg

Water 133.43kg Effluent 134.16kg

Hyflo=0.76kg

Methanol 25 kg Hyflo for solid

waste 0.76kg

Methanol for

Recovery77.5kg

Methanol loss 4 kg

Reactor


at 20°C to 25°C)

Reactor

(Charging at 25°C

to 30°C)

Reactor


50°C)

Nutche Filter

(Hyflo at 25°C to

30°C)

Reactor


to 70°C)

Reactor

(Layer Separation)


68

Acetone 334 kg

Acetone

Recovery31.43 kg

Acetone loss =1.34kg

Hydrogen0.17kg Process

Emission0.073kg

Acetone 20kg Acetone ML for recovery

Organic Impurities



Stage-I 15 kg

Isopropyl Alcohol 50kg

Centrifuge / Nutche

Filter


10°C)

Reactor

(Distillation for

at 55°C to 60°C)

TD / VTD

(Drying at 60°C to

65°C)

Reactor


at 25°C to 30°C)

Reactor


at 25°C to 30°C)

Hydrogenation


69

Sulfuric Acid0.34kg

Water 250kg Aqueous layer for ETP252kg


Isopropyl Alcohol Recovery 47kg

Isopropyl alcohol loss 2.33kg

Isoprpyl Alcohol =10kg Isopropyl Alcohol ML for Recovery

Reactor

(Distillation at

115°C to 130°C)

Reactor


45°C to 50°C)

Reactor

Digestion and cool

15 °C to25 °C)

Centrifuge / Nutche

Filter


10°C)

TD / VTD

(Drying at 60°C to

65°C)

Reactor

(Layer Separation)

Reactor


at 55°C to 60°C)


70



Stage-II compound 12.57kg

Water 133.3kg

Hydrogen Peroxide(50%)

3.33kg

Ammonia solution(10%)

8.33kg

Water 133.3 kg Aqueous layer for

ETP145. kg

Reactor


30°C)

Reactor


40°C)

Reactor


30°C)

Reactor

(Stir for 2hrs at 45°C

to 50°C)

Reactor


30°C)

Reactor

(Layer Separation)

Centrifuge / Nutche

Filter


30°C)


71

Stage-3 Compound=11.7 kg


Stage-3 Compound 11.7 kg

Methanol 83.4 kg

Palladium Carbon 1kg

Hyflo 1kg

Hyflo for solid waste 1

kg

Water 116 kg

Aqueous layer for ETP117.5kg

Reactor


50°C)

Reactor


40°C)

Reactor

(Layer separation)

Reactor

(Stir 60 minute at

45°C to 50°C)

TD/VTD

(Drying at 60°C to

65°C)

Nutche Filter

(Hyflo at 25°C to

30°C)


72

Methanol for Recovery77.7kg

Methanol loss 4 kg

Process Emission0.093kg

Hydrogen 016 kg

Methanol 15 kg Methanol ML for waste

Solvent 10.725 kg

Stage-4 Compound =10.3 kg

Stage-5: Preparation of Finasterde

Stage-4 Compound 10.3kg

P-Toluensulfonic Acid0.34kg

Toluene 83.4kg

Tert-Butylamine2.5kg

Centrifuge / Nutche

Filter


30°C)

TD/VTD

(Drying at 60°C to

65°C)

Reactor


30°C)

Reactor


40°C)

Reactor


to 65°C)

Reactor

Hydrogenation


73

Toluene Recovery79.3kg

Toluene loss 3.16kg


Water100kg Aqueous for ETP 101.08kg

Isopropyl Alcohol 33.33kg


Isopropyl Alcohol Recovery 38.7kg

Acetone loss 2.05kg

Isopropyl Alcohol 15kg Organic Impurities 10.12kg

Acetone ml for recovery


Reactor


to 115°C)

Reactor


25°C)

Reactor


80°C)

Centrifuge / Nutche

Filter


30°C)

TD/VTD

(Drying at 60°C to

65°C)

Reactor

Layer separation


74

Stage-6: Preparation of Finasterde

Stage-5 compound 11.5kg

DDQ 7.3 kg

Toluene 66.6kg

Toluene Recovery 63.33kg

Toluene loss 2.66kg

Toluene 25kg Toluene ML for Recovery

Finasteride =10.30kg

Reactor


90°C)

Reactor


to 120°C)

Reactor


25°C)

Reactor


25°C)

TD/VTD

(Drying at 60°C to

65°C)

Reactor


25°C)

Centrifuge / Nutche

Filter


30°C)


75

Product Name: Paracetamol

CAS No.: 103-90-2

Stage-1: Preparation of Paracetamol

P-Aminpohenol=134.8kg

Acetic anhydride=126.2kg

DM water / ML Pharma =164

Zinc =0.002kg

EDTA=0.06kg

25°C to 30°C)

Zinc =0.002kg Zinc=0.002kg

DM Water 13kg

EDTA 0.06kg

Acetic acid by product 240kg

To ETP (ML)10.8kg

Reactor

(Crystallization cooling for

15 °C to 20°C)

)

Concentration ML

Tech II -Crop

Reactor


30°C)

Reactor

(Distillation at 55°C to 60°C)

Nutche Filter

(Filtration at 25 to 30)

Reactor

(ML Para + Dil Acetic Acid)

Reactor

(Stirring for 2 hr at 50

°Cto 60 °C)


76

Stage -I product =186.6 kg

Stage-2: Preparation of Paracetamol

Para Crystal /tech =186.6

Hydrose 0.004 kg

soda ash0.02kg

Activated charcoal 0.1kg Spent Carbon0.1 kg

Reactor


30°C)

Reactor


30°C)

TD /VTD (Drying at 55°C to

60°C)

Centrifuge /Nutche

Filter at 5°C to 10°C)

Reactor

(Cooling for

Crystallization15°C to 20°C)

Reactor

(Heating at 55°C to 60°C)


77

Storage Tank

DM water 0.5 To Recycle

(ML Wash & ML)

Paracetamol=166.66 kg

Nutche Filter


30°C)

Drying at 60°C °C

to 65


78

Product Name: Ketorolac Tromethamine

CAS No.: 74103-07-4

Stage-1: Preparation of Ketorolac Tromethamine

Pyrrole 20.83 kg

Cyclohexane145.83 kg

Benzoyl Chloride 44.791kg

Aluminum Chloride 41.66kg


Water 625kg Effluent 742.6kg

Acetone 104.16kg

Acetone Recovery97.9kg

Acetone loss4.16kg

Cyclohexane139kg

Cyclohexane loss5kg

Reactor


at 20°C to 25°C)

Reactor

(Charging at 25°C

to 30°C)

Reactor


50°C)

Reactor


40°C to 45°C)

Reactor


to 70°C)

Reactor

(Layer Separation)


79

Acetone 20kg Acetone ML for recovery

Organic Impurities



Stage-I 45.2kg

Perchloric Acid 27kg

Cyclohexane208kg

Water750kg Aqueous layer for ETP755kg

Centrifuge / Nutche

Filter


10°C)

Reactor


at 25°C to 30°C)

Reactor


45°C to 50°C)

Reactor

Diegation and cool

15 °C to25 °C)

TD / VTD

(Drying at 60°C to

65°C)

Reactor

(Layer Separation)


80

Organic Residue8.5kg

Cyclohexane Recovery197.9kg

Cyclohexane loss 8.33kg



Stage-II compound47.91kg

Methy-yMethoxy butanodte

31.25kg

Acetone 250 kg

Sodium Hydroxide 19.58 kg

Reactor


to 60°C)

Reactor


30°C)

Reactor


40°C)

Reactor


30°C)

Reactor


45°C to 50°C)

Centrifuge / Nutche

Filter


10°C)

TD / VTD

(Drying at 60°C to

65°C)


81

Methanol 50kg waste 8.300 kg

Acetone recovery 87.91 kg

Acetone loss 10.41kg

Water 479.13kg

Aqueous layer for ETP 521kg

Methanol140kg

Methanol recovery150kg



Methanol 15 kg Methanol ML for waste

Solvent 10.725 kg

Nutche Filter

(filtration at 25°C to

30°C)

Reactor


to 50°C)

Reactor


50°C)

Reactor


50°C)

Reactor

(Stir 60 minute at

25°C to 30°C)

Centrifuge / Nutche

Filter


30°C)

Reactor


to 65°C)

Reactor

(Stir 60 minute at

45°C to 50°C)


82



Stage-3 Compound 52.08kg

(Ketorolac)

Acetone41.66kg

Triamethamine25kg


Acetone Recovery 38.7kg

Acetone loss 2.05kg

TD/VTD

(Drying at 60°C to

65°C)

Reactor


30°C)

Reactor


40°C)

Reactor


70°C)

Reaction and mass

cool


25°C)

Reactor


80°C)


83

Acetone 50kg Organic Impurities 10.12kg

Acetone ml for recovery

Ketorolac Tromethamine=66.66kg

Centrifuge / Nutche

Filter

(Filtration at 25°C

to 30°C)

TD/VTD

(Drying at 60°C to

65°C)


84

Product Name: Metformine HCL

CAS No.: 1115-70-4

Stage-1: Preparation of Metformine HCL

Dimethyl Formamide

(DMF) 293 kg

Toluene 194 kg

Dimethylamine HCL 23

Dicyandiamide 305 k

Toluene Recovery =186 kg

Toluene loss= 0.6

Water =40kg

Reactor

(Charging at 25 to

30°C)

Re-flux & Distillation

at 100°C to 115°C)

Reactor

Agitation at 136°C

an

Reactor

(Charging at 25 to

30°C)

Reactor


25°C to 30°C)

Reactor


25°C to 30°C)

Reactor

Agitation stirring and

cool 15-20 °C


85

Aqueous layer for ETP =40kg

DMF 25 kg CF MLs sent for

DMF

Recovery

MFM Technical

Methanol 32 kg

Carbon 4.8 kg

Methanol =5 kg Carbon for waste

4.8 kg

Methanol =3kg Pharma ML for Recovery

Centrifuge

Reactor


30°C)

Reactor

Heating to clear solution

at 55°C to 60°C)


10°C)

Carbon separation

Reactor

( Layer separation )

Crystallization

Agitation & Cool to

0.5 °C

Centrifuge


86

Metformin HCl = 500 kg

TD / VTD

(Drying at 60°C to

65°C)


87

Product Name: Neostigmine Methylsulfate

CAS No.: 51-60-5

Stage-1: Preparation of Neostigmine Methylsulfate

3-(Dimethylamino) phenol 4.2 kg

Toluene 44.66kg

Potassium Hydroxide 3.4 kg

Dimethylamine Chloride

5.13kg

Water 44.66 kg Aqueous layer ETP

51.05kg

Reactor

(Charging at 100°C

to 110°C)

Reactor

(Stirring for 4 hrs. for

Reaction of mass

Reactor

(Layer Separation)

Reactor

(Charging at 25°C

to 30°C)

Reactor

(Stirring for 30min for

at 100°C to 110°C)

Reactor


55°C to 60°C)


88

Toluene Recovery 42kg

Toluene loss 1.8kg


Toluene 15kg Organic

Impurities14.17kg

Ethyl acetate 6.27


Stage-2: Preparation of Neostigmine Methylsulfate

Stage-I= 5.533kg

Acetone =22kg

Dimethyl sulfate 4 kg

Reactor


to 120°C)

Centrifuge/Nutche

Filter


10°C)

TD / VTD

(Drying at 60°C to

65°C)

Reactor

(Charging& Stirring for

2 hour at 25°C to

30°C)

Reactor


30°C)

Reactor

(Cool and Digestion for

2 hrs at 15-°C

25°C


89

Acetone Recovery 20.46kg

Acetone loss 1.133


Acetone 4 kg Acetone ML for Recovery

Organic Impurities2.27kg

Neostigmine Methylsulfate=6.66kg

Reactor


to 50°C)

Centrifuge / Nutche

Filter


10°C)

TD / VTD

(Drying at 60°C to

65°C)


90

Product Name: Phytomenadione

CAS No.: 84-80-0

Stage-1: Preparation of Phytomenadione

Acetic Anhydride 13 kg

Menadione 28kg

Methanol 60kg

Zinc Added 10kg

Methanol 10. kg Methanol Ml for Recovery

Inorganic waste 3.33 kg

Zinc Acetate 28.16 kg

Nutche Filter


30°C)

Reactor


80°C to 90°C)

Reactor

(Reaction of mass

Generation & cool at 15°C

to 20°C)

Reactor


30°C)

Reactor


50°C)

Reactor


40°C to 45°C)


91

Methanol Recovery33kg

Methanol loss 2 kg


Potassium Carbonate11kg

Water 130 kg Aqueous layer for ETP

144.84 kg

Hydrogen 1kg Hydrogen1.16kg

Carbon dioxide 3.51kg

Methanol 9 kg Methanol Ml for recovery

Stage -I Compound =14 kg

Reactor


30°C)

Reactor


to 70°C)

Reactor

(Layer Separation)

Reactor


30°C)

Reactor


30°C to 35°C)

TD / VTD

(Drying at 60°C to

65°C)

Centrifuge / Nutche

Filter


10°C)


92


Stage I = 14 kg

Methanol 40 kg

Methylene Dichloride 230kg

Phytol 20 kg

Methanol 10 kg Methanol ML for Recovery

Organic Impurities 6.98kg

Methylene Dichloride loss 14kg

Methylene Dichloride Recovery212kg

Methanol recovery 46.5 kg

Methanol loss 2.5kg

Water100 kg Aqueous layer for ETP

113.89 kg

Reactor


30°C)

Reactor


30°C)

Reactor


30°C)

Reactor


25°C to 30°C)

Nutche Filter

( filtration at 25°C to

30°C)

Reactor


to 50°C)

Reactor

(Layer Separation)


93

Methanol 6 kg MethanolML for Recovery

Process Emission 0.13kg

Phytomenadione (Crude)=23kg


Phytomenadione (Crude)=23kg

Cyclohexane = 952 kg

Silica gel 92 kg

Organic Residue 4kg

Cyclohexane Recovery 87kg

Cycloxehane loss 46kg

Reactor

(Stir 60 minute at

25°C to 30°C)

Centrifuge / Nutche

Filter


30°C)

TD/VTD

(Drying at 60°C to

65°C)

Reactor


30°C)

Reactor


70°C)

Reactor

(Charging at 25°C

to 30°C)


94

Cyclohexane 10kg Cyclohexane

ml Recovery

Inorganic Impurities 3kg

Phytomenadine=20kg

TD / VTD

(Drying at 60°C to

65°C)

Centrifuge / Nutche

Filter


30°C)


95

Product Name: Voriconazole

CAS No.: 137234-62-9

Stage-1: Preparation of Voriconazole

3-(6-Chloro-5-Floropyrimidin-4 yl)

-2-(2,4-Difluorphenyl)-1-

(1H-1,2,4-Trial-1-yl)butan

-2-ol= 12.67 kg

Methanol =50.7 kg

Sodium Acetate 32kg

Raney Ni4.4kg

Hydrogen 4-6 kg/cm2

Organic Residue 1.66 kg

Methanol Recovery47.33kg


Raney NIi4.4kg

Water133.4kg Aqueous layer for ETP

138.272kg

Reactor


40°C to 45°C)

Reactor


40°C to 45°C)

Reactor

(Charging at 25°C

to 30°C)

Reactor


50°C)

Reactor

(Stirring for 7 hour

at 40°C to 45°C)

Reactor


to 70°C)

Reactor

(Layer Separation)


96

Methanol 6. kg Methanol ML for Recovery

Stage-I Compound =10.4 kg

Stage-2: Preparation of of Voriconazole

Stage -II Compound 10.4kg

Acetone 52kg

R(-1) -10-Comphors

Sulfuric Acid 7.33kg

Methanol 20 kg

Centrifuge / Nutche

Filter


30°C)

Reactor


at 25°C to 30°C)

Reactor

(Charging at 45°C

to 50°C)

Reactor

(Digestion and cool at

20°C to 25°C)

TD / VTD

(Drying at 60°C to

65°C)


97

Acetone Recovery49kg

Acetone loss 2.4kg

Methanol Rercovery24.7kg

Methanol loss 1.0kg


Methanol 5kg Methanol Ml for recovery

Stage -II Compound =14.67kg

Stage-3: Preparation of of Voriconazole

Stage -II compound14.67kg


Methylene Dichloride44kg

Reactor

(Digestion and cool at

15°C to 20°C)

Reactor

(Charging at 25°C

to 30°C)

Reactor


to 65°C)

Reactor

(Reaction of mass at

40 °C to 45 °C )

Centrifuge / Nutche

Filter


10°C)

TD/VTD

(Drying at 60°C to

65°C)


98

Water 146.2kg Aqueous layer for ETP

153.9kg

Recovery Methylene Dichloride

40.66kg

Methylene Dichloride loss2.66kg

Propanol 48.7kg

Propanol 10 kg

Propanol ML for recovery

Voriconazole =6.66kg

Reactor

(Stir for 12 hour at 25°C

to 30°C)

Reactor


70°C)

Reactor


35°C)

Centrifuge / Nutche

Filter


10°C)

Reactor

(Layer Separation)

TD/VTD

(Drying at 60°C to

65°C)


99


100


101


102

VI. Raw Material Required

In the proposed project 107 no. of products will be manufactured hence

numerous raw materials will be required. Detailed product-wise raw materials

requirement is presented in Annexure I.

VII. List of Plant Machineries

In API manufacturing industries various equipment are required on process to

process. It includes Reactor (glass), Centrifuge, Dryer, Filter, Multimill,

Blender, Distillation Column, Heat Exchanger and auxiliary such as Boiler,

Chiller, Cooling Tower, Wet Scrubber, DG , Pumps, Air Handling unit,

Nitrogen Plant, Tanks, DM Water & RO system etc. Detailed equipment list

with capacity is presented in Annexure II.

VIII. Resource optimization/recycling and reuse

Proposed industry is involved in API manufacturing. Resources such as

infrastructure, equipment’s and manpower will be required in proposed project.

In proposed project, industry will recycle waste water from cooling tower, make

up through inhouse ETP and propose RO & multiple effect evaporator system.

IX. Availability of water its source, Energy/ power requirement

Water

Total water requirement would be 148KLD and it will be supplied either by

competent authority. Detailed water budget is presented in below table

Table No. 3: Water Budget

Sr.

No.

Use of Water Water Requirement (KLD) Loss

(KLD)

Waste Water

(KLD)

Remark

Consumption Remark

1. Domestic 10 Fresh-10 1.5 8.5 Sewage treated in 10

CMD of STP

2. Industrial Process 35 Fresh from

RO-35

5 30 Treated in ETP

followed by MEE

3. Cooling tower

makeup

32 Fresh-8

Recycle-24

8 24 Treated in ETP of

85 CMD

4. Boiler makeup 24 Fresh-10

Recycle-14


85 CMD


103

5. Washing 15 Fresh-5

Recycle-10


85 CMD

6. Scrubber 2 Fresh-2 0 2 Treated in ETP of

85 CMD

7. Gardening 30 Recycle-30 30 0

Total 148 Fresh-70

Recycle-78

95.5 Sewage-8.5KLD

Effluent-87 KLD

Power

The total power requirement for industry is 3000kVA. It will be supplied by MSEDCL.

In case of Emergency, 2 no. of DG sets of 75 kVA will be installed on the site which

will be used to run inhouse ETP, STP and common lights.

Waste Generation & Management

Construction Phase: Average construction waste generation over the period of

construction would be 25MT which is inclusive of metal pieces, steel, cardboard, rags

etc. which will be segregated as per their characteristics & disposed off through

authorized vendor. Hazardous solid waste generated will be collected, stored,

transported and disposed as per Hazardous And Other Wastes (Management and

Transboundary Movement) Rules, 2016 .Municipal solid waste generated from labours

will be segregated into dry and wet waste which will be disposed off through local

municipal body.

Operation Phase: In operation phase generated domestic solid waste will be in the

form of dry waste and wet waste. Domestic wet waste and dry waste will be disposed

off through local body.

Hazardous solid waste generated will be collected, stored, transported and disposed as

per Hazardous and Other Wastes (Management and Transboundary Movement) Rules,

2016. Details of hazardous & non-hazardous are presented in Table No. 3 & Table

No.4, respectively.

E-waste will be disposed off with the help authorized E waste vendors. Almost all

computer & server providing companies like IBM, DELL, Acer and Wipro provide

services for E-waste management like buyback, recycling or disposal facility.


104

Table No. 4: Details of Non-Hazardous Waste

Sr. No. Description UOM Total Treatment

1 Wooden Material Kg/M 500 Sale to Authorized recycler

2 Glass scrap Kg/M 500 Sale to Authorized recycler

3 HDPE Drums Nos/M 150 Sale to Authorized recycler

4 Plastic scrap & other non-

biodegradable waste

Kg/M 250 Sale to Authorized recycler

5 Paper waste Kg/M 100 Sale to Authorized recycler

6 e-Waste Kg/A 100 Sale to Authorized recycler

Table No.5: Details of Hazardous Waste

Sr.

No. Description Cat UOM Total Method Of Disposal

1 Spent Oil/ used

waste 5.1 kg/month 50

Through authorised recycler/

reprocessor

2 Spent Solvents 20.2 kg/Month 18000

CHWTSDF, Mumbai Waste

Management Limited, Taloja

3 Distillation residue 20.3 kg/month 2000



4 Spent Catalyst/

Spent Carbon 28.2 kg/month 800



5 Discarded

containers 33.3 no. / Month 300 Sale to authorised dealer

6 Sludge from waste

water treatment 34.3 kg/month 150



7 Spent Mother

Liquor 28.4 kg/month 16000



8 Spent organic

solvent 28.5 kg/month 10000

Sale to authorised

recycler/reprocessor

9 Chemical Sludge,

oil & grease

skimming residue

34.3 Kg/month 200 CHWTSDF, Mumbai Waste



105

X. Schematic representations of the feasibility drawing which give information of

EIA purpose.


106

4. Site Analysis

I. Connectivity

The project site is adjacent to Tarapur MIDC. It is well connected through road,

railway, and airport. Access road is Navapur road which is about 0.3 km from

the project site. Nearest Railway station is Boisar at an aerial distance of ~5kms

& Chhatrapati Shivaji International Airport, Mumbai is at an aerial distance of

80.39 kms from project site.

II. Land Form, Land Use & Land ownership

Land form is barren land, proposed site is NA land for industrial purpose as per

7/12 extract and it is under possession of proponent.

III. Topography

The topography of proposed site is flat.

IV. Existing Land use pattern

Total plot area of M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd. is 28200 Sqm.

Site is located adjacent to well-developed Tarapur MIDC area. Surrounding area

is already developed for industrial purpose. The proposed site shares the

boundary of Tarapur MIDC towards East. The proposed site is surrounded by

industries viz Ms. Nandolia Organic Chemicals Pvt Ltd., Lupin Ltd., JPN

Pharma Pvt., Aarti Industries. Lupin Ltd. and Nandolia Organics Chemicals Pvt

Ltd. are adjacent to the proposed plot boundary towards North-East and South

respectively.

V. Existing Infrastructure

The list of existing infrastructure at the project site is as follows

1. Water supply will be from Competent authority.

2. Access road is Navapur road at an aerial distance of 0.3 km which is 6 meter

wide


107

3. State highway -74 (Boisar Tarapur road) which is towards North East direction

at an aerial distance of 3.26 km and NH-8 which is towards East of project site

at an aerial distance of 20 km away.

4. Power supply will be from MSEDCL

5. Storm water drainage system will be designed as per Contour of site

6. Industrial wastewater from the industry will be treated in proposed inhouse Zero

discharge Eco Friendly ETP.

7. Hazardous waste and Non Hazardous waste will be stored separately. Hazardous

waste and residues will be sent to Mumbai Waste Management Ltd. (Common

Hazardous Waste Treatment Storage & Disposal facility), MIDC Taloja, Tal-

Panvel Dist-Raigad. Wet and dry waste will be disposed off through local body.

VI. Soil Classification

The region is underlain by basaltic rocks. Basalt flow forms the predominant formation

capped at a few places by laterite at higher levels. A number of hot springs occur in

Thane district which have positive relation with the geology of the area. Basalt flows,

popularly known as Deccan traps, forms the predominant formation. It is capped by

laterite on a few high plateaus and covered by shore sands along the coast. A general

geological sequence is Shore sand- Recent, Laterite-Pleistocene and Basalt-Eocene.

VII. Climate data from secondary sources

The data on various meteorological parameters for the nearest IMD station i.e.

Thane has been referred from IMD publication titled ‘Climatological Normals

1981-2010’.

a. Seasons

The location of the town being in the hot and temperate region and in the areas

covered by the south western prevailing winds, there are two distinct seasons,

one extending from mid-June to September, and the other for the rest of the year.

In this season there are rare rains due to local cyclones or depressions.

b. Rainfall

The total annual rainfall is 1874.6 mm. The maximum total monthly rainfall

amounting to 650.7 mm occurred in the month of July.

c. Temperature

The maximum temperature of 36.3oC was recorded in the month of May while


108

the lowest temperature of 14oC was recorded in the month of January.

d. Humidity

The relative humidity at 8.30 am ranged from 63% (February) to 88% (July &

August) while at 5.30 pm, it ranged from 62% (March) to 84% (July).

e. Wind Direction

The maximum mean wind speed was recorded to be 16.6 kmph in the month of

July. The predominant wind direction at 8.30 am was recorded to be from East

followed by South-West while the same at 5.30 pm was recorded to be from

South-West followed by West.


109

5. PLANNING BRIEF

I. Planning Concept

The proposed industry will be developed as per local planning approval

authority of Palghar.

II. Population Projection

In construction phase of the proposed industry around 30 nos. labourers will be deployed on the

site, similarly in operation phase of the industry will generate employment for approximately

150 nos of persons. Therefore, there will be temporary increase in the population during the

construction stage and operation phase of the industry.

III. Land use Planning

The industry will be designed envisaging adequate area for landscape, process section

and utilities, storage areas for raw materials, finished products and internal movement of

vehicles. Detailed land use is presented in below table

Table No. 5 : Site Land Use

IV. Assessment of Infrastructure Demand

Project site is adjacent to Tarapur MIDC. Hence all existing infrastructure like road,

electricity, water, fire station and other facilities etc are already developed around

the project.

V. Amenities/Facilities

In proposed project, amenities like ware house facility, security cabin and utilities

like Tank farm, U.G Tank, ETP, STP, 400 TR capacity cooling tower, Chilling plant

will be installed. To achieve Zero Liquid Discharge (ZLD) Scheme, RO followed by

Evaporator will be installed at inhouse ETP.

Plot Area : 28200 Sq.M.

Proposed Built-Up Area : 14097 Sq.M

Proposed ground coverage : 5565Sq.M.

Green Belt Area : 4551.34 Sq.M (16.1% of Plot Area)


110

6. Proposed Infrastructure

7. Rehabilitation and Resettlement (R & R) Plan

Proposed project site is already under possession of proponent, hence R&R plan is not

applicable.

Plot Area : 28200 Sq.M.

Proposed Built-Up Area : 14097 Sq.M

Green Belt Area : 4551.34 Sq.M

Social Infrastructure : E learning facility (computers) will be provided in

primary school, Pam village.

Connectivity : Navapur Road is already developed.

Drinking water management : Competent Authority

Sewerage System : During construction phase septic tank followed by soak

pit will be provided.

Industrial waste : Industrial hazardous waste will send to CHWTSDF

facility,Mumbai Waste Management, Taloja while non-

hazardous waste will be disposed off through

authorized vendor.

Solid waste management : Generated domestic solid waste will be segregated as

dry waste & wet west and disposed off as per solid

waste management rules 2016.

Power Requirement & Supply : Total power demand of the project would be 3000kva

and it will be supplied through MSEDCL.


111

8. Project Schedule & Cost Estimates

I. Likely date to start of Construction & likely date of completion

Proposed industry will be established after obtaining Environment Clearance from

Expert Appraisal Committee (EAC)-Industry2, MoEF&CC New Delhi and after

obtaining relevant NOCs from concerned statutory authorities. The total time

requirement for completion of construction would be 18 months from the start of

construction.

II. Estimated Project Cost

Estimated total cost of the project would be Rs. 45.17 crores.

9. Analysis of Proposal

I. Financial & Social Benefits

M/s. Ciron Drugs and Pharmaceuticals Pvt Ltd. has proposed manufacturing of API

industry, which will be used as a raw material for preparation of various medicines for

curing different diseases in social community & help maintain healthy life. M/s. Ciron

Drugs and Pharmaceuticals Pvt Ltd. has own drug formulation unit in Tarapur region

hence proposed project will reduce cost of outsourced API which ultimately results in

reduction of cost medicine production. Thus, the project is having social benefit in

terms of production of API for medicines.

Considering financial point of view, proposed API can be exported to various countries

which will be beneficial to the company and the government.

The management of the industry proposes to give preference to local people with both

direct and indirect employment.

Annexure I: Detailed product-wise raw materials requirement

Sr.

No Category Name of Product RM Names

Quan

tity

in

(Kg)

Qua

ntity

requ

ired

for 1

Kg

API(

Kg)

Requir

ement

of Raw

Materi

al

(MT/M

)

Charact

eristics

of Raw

Material

(Hazard

ous/

Non-

Hazardo

us)

Flamm

ability

of

Materi

al

(Flam

mable

& Non-

flamma

ble)

One

-

tim

e

stor

age

wit

hin

pla

nt

(M

T)

Mode of Storage

& Transport

Hydrocortisone

0.952 2.07 2.07 Hazardou

s

Non-

Flamm

able 1.0

1

HDPE

carbouy(ByRoad)

Pyridine

2.857 5.21

2 5.212

Hazardou

s

Flamm

able 1.5

6

HDPE

carbouy(ByRoad)

Acetic acid

0.952 2.07 2.07 Hazardou

s

Flamm

able

1.0

15

HDPE

carbouy(ByRoad)

1 Antihistaminic Hydrocortisone sod succinate Acetic anhydride

2.857 5.21

2 5.212

Hazardou

s

Flamm

able 3.1

HDPE

carbouy(ByRoad)

DM water 57.14

2

112.

132

112.13

2 Non

Hazardou

Non-

Flamm

85.

13 In Tank ( Transport

NA)


1

s able

Dimethyl Formamide

4.762 9.6 9.6 Hazardou

s

Flamm

able 5.1

HDPE

carbouy(ByRoad)

Charcoal

0.095 0.21

5 0.215

Hazardou

s

Non-

Flamm

able 0.1

HDPE

carbouy(ByRoad)

Hyflow

0.048 0.92 0.92 Hazardou

s

Non-

Flamm

able 0.1

2

HDPE

carbouy(ByRoad)

Sodium Hydroxide

0.25 0.58 0.58 Hazardou

s

Flamm

able 0.5

1

HDPE

carbouy(ByRoad)

Antihistaminic Hydrocortisone sod

succinate

Hydrocortisone

0.952 2.07 2.07 Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

Pyridine

4.762 5.21

2 5.212

Hazardou

s

Flamm

able 5.2

HDPE

carbouy(ByRoad)

Succinic Anhydride

0.952 2.07 2.07 Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

DM water 37.14

2 55 55 Non

Hazardou

Non-

Flamm 55

Tank

(ByRoad)NA


2

s able

Hydrochloric Acid

1.905 2.5 2.5 Hazardou

s

Non-

Flamm

able 2.5

HDPE

carbouy(ByRoad)

Charcoal

0.095 0.1 0.1 Hazardou

s

Non-

Flamm

able 0.1

2

HDPE

carbouy(ByRoad)

Hyflow

0.04 0.08 0.08 Hazardou

s

Non-

Flamm

able 0.0

9

HDPE

carbouy(ByRoad)

Acetone

8.095 0.92 0.92 Hazardou

s

Flamm

able 0.1

HDPE

carbouy(ByRoad)

1


0.58 0.58 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Antihistaminic Methyl prednisolone sod

succinate

Methylprednisolone 0.952

2.07 2.07 Hazardou

s

Non-

Flamm

able 0.1

HDPE

carbouy(ByRoad)

Pyridine 4.762

9.12 9.12 Hazardou

s

Flamm

able 5.2

HDPE

carbouy(ByRoad)

Succinic Anhydride 1.905 2.07 2.07 HazardouNon-

Flamm2.1

HDPE


3

s able carbouy(ByRoad)

Acetone 4.762

9.12 9.12 Hazardou

s

Non-

Flamm

able 6.1

HDPE

carbouy(ByRoad)


0.58 0.58 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

DM water 32.38

1 70.1

3 70.15

Hazardou

s

Non-

Flamm

able 40.

1

HDPE

carbouy(ByRoad)

Charcoal 0.095

0.1 0.1 Hazardou

s

Non-

Flamm

able 0.1

HDPE

carbouy(ByRoad)

2

Hyflow 0.048

0.12 0.12 Hazardou

s

Non-

Flamm

able 0.0

9

HDPE

carbouy(ByRoad)

3 Antispasmodics Methyl prednisolone

acetate

Methylprednisolone 0.952

2.07 2.07 Hazardou

s

Non-

Flamm

able 1.1

HDPE

carbouy(ByRoad)

Pyridine

2.857 5.21

2 5.212

Hazardou

s

Non-

Flamm

able 3.1

HDPE

carbouy(ByRoad)


4

succinic Anhydride

0.952

2.07 2.07 Hazardou

s

Non-

Flamm

able 1.1

HDPE

carbouy(ByRoad)

Acetone

2.857 5.21

2 5.212

Hazardou

s

Non-

Flamm

able 3.1

HDPE

carbouy(ByRoad)

DM water

52.38

1 112.

132

112.13

2

Non

Hazardou

s

Non-

Flamm

able 55

HDPE

carbouy(ByRoad)

Dimethyl Formamide 4.762

9.6 9.6 Hazardou

s

Flamm

able 5.1

HDPE

carbouy(ByRoad)

Charcol

0.095

0.12 0.12 Hazardou

s

Non-

Flamm

able 0.1

HDPE

carbouy(ByRoad)

Hyflow

0.048

0.92 0.92 Hazardou

s

Non-

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

Antihisaminic Adrenaline

Ammonia solution 0.19

0.3 0.3 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

DL-Adrenaline 0.2

0.45 0.45 Hazardou

s Non-

Flamm 0.3

HDPE

carbouy(ByRoad)


5

able

IPA 1.5

3 3 Hazardou

s

Flamm

able 1.8

HDPE

carbouy(ByRoad)

Tatric Acid 0.1

0.21 0.21 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Anti-hypotenstion Nor adrenaline

Ammonia solution (20%) 0.19

0.3 0.3 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

DL-Nor Adrenaline 0.2

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

soduim Bisulphite 1.5

3 3 Hazardou

s

Non-

Flamm

able 1.8

HDPE

carbouy(ByRoad)

Tartric Acid 0.1

0.21 0.21 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

5

Antihisaminic Dexamethasone sod

phosphate micronised

Dexamethasone base 0.25 0.6 0.6

Hazardou

s Non-

Flamm 0.3

HDPE

carbouy(ByRoad)


6

able

THF 0.175

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Water 25

55 55

Non

Hazardou

s

Non-

Flamm

able 35

Tank

(ByRoad)NA

Pyro phosphoryl chloride 0.25

0.6 0.6 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Methanol 13

30 30 Hazardou

s

Flamm

able 18

HDPE

carbouy(ByRoad)

Activated Carbon 0.03 0.07

9 0.079

Hazardou

s

Non-

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

Acetone 40

85 85 Hazardou

s

Flamm

able 50

HDPE

carbouy(ByRoad)

soduim hydroxide 25

60 60 Hazardou

s

Non-

Flamm

able 30

HDPE

carbouy(ByRoad)

Ethyl Acetate 30

65 65 Hazardou

s

Flamm

able 40

HDPE

carbouy(ByRoad)


7

Water 25

55 55

Non

Hazardou

s

Non-

Flamm

able 30

Tank

(ByRoad)NA

7

Anti-

migrain/Anti-

postpartum

Carboprost

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

8 Antispasmodics Succinyl choline chloride

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

9 Anti-psychotic Phenobarbitone and

phenobarbitone sod

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

10 Anticonvulsant/A

ntiepileptic drug Midazolam

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

2-(2'-aminomethyl carbonyl

Methoxyl)-7chloro -5-(2-

Fluoro Phenly)-1,3-dihydro-

2H-1,4-benzodiazepine

0.189 0.38

1 0.381

Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Tri ethyl ortho acetate

0.112 0.22

8 0.228

Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)


8

NaoH

0.027 0.05

9 0.059

Hazardou

s

Non-

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Conc.HCL

0.109

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Methanol 0.32

0.69 0.69 Hazardou

s

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Water

0.25

0.5 0.5

Non

Hazardou

s

Non-

Flamm

able

Tank

NA(ByRoad)

11 Anticonvulsant/A

ntiepileptic drug Lignocaine 2:6 Xylidine

0.15

0.32 0.32 Hazardou

s

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

Chloroacetyl Chloride

0.18

0.36 0.36 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Soda ash

0.21

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Toluene 20

40 40 Hazardou

s Flamm 25

HDPE

carbouy(ByRoad)


9

able

Diethylamine

1

2 2 Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

Acetone 15

33 33 Hazardou

s

Flamm

able 20

HDPE

carbouy(ByRoad)

Anticonvulsant/A

ntiepileptic drug Bupivacaine 2,6 Piperidine Xylidide

0.81

1.5 1.5 Hazardou

s

Non-

Flamm

able 0.9

1

HDPE

carbouy(ByRoad)

N-Butyl Bromide

0.56

0.9 0.9 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Isopropyl Alcohol (IPA) 5.59

9.2 9.2 Hazardou

s

Flamm

able 6.1

HDPE

carbouy(ByRoad)

Potassium carbonate

0.43

0.96 0.96 Hazardou

s

Non-

Flamm

able 0.5

6

HDPE

carbouy(ByRoad)

Activated Carbon/hyflo

0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

12


10

Anti-

glaucoma/Antiocu

lar hypertenstion

Latanoprost

3,3a,4,5,6,6a-hexahydro-2oxo-

4hydroxy methyl-5-(4'-phenyl

benzoyloxy)-2H-Cyclopenta

[b] furan

0.27

0.56 0.56 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Potassium hydroxide 0.5

1 1 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Methylene chloride 0.285

0.58 0.58 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

water 14.3

28.9 28.9

non

Hazardou

s

Non-

Flamm

able 15

Tank NA

carbouy(ByRoad)

Con. Hydrochloric acid 4.36

8.5 8.5 Hazardou

s

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

Soduim sulphate 0.52

0.91 0.91 Hazardou

s

Non-

Flamm

able 0.6

5

HDPE

carbouy(ByRoad)

Methanol 4.62

8.9 8.9 Hazardou

s

Flamm

able 5.6

HDPE

carbouy(ByRoad)

ethyl Acetate 15.25 31.2

5 31.25

Hazardou

s

Flamm

able 20

HDPE

carbouy(ByRoad)


11

Diisopropyl ether 11

22 22 Hazardou

s

Flamm

able 12.

2

HDPE

carbouy(ByRoad)

Ab.ethanol 2.2

4.2 4.2 Hazardou

s

Flamm

able 2.5

HDPE

carbouy(ByRoad)

10% Pd/C 0.14

0.28 0.28 Hazardou

s

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

Sodium nitrite 0.072 0.09

8 0.098

Hazardou

s

Non-

Flamm

able 0.0

82

HDPE

carbouy(ByRoad)

sodium bicarboante 0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

Sodium hydrogen sulphate 0.34

0.75 0.75 Hazardou

s

Non-

Flamm

able 0.4

1

HDPE

carbouy(ByRoad)

Hexane 0.12

0.24 0.24 Hazardou

s

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

4-carboxybutyl triphenyl

phosphonium bromide

0.532

0.9 0.9 Hazardou

s

Non-

Flamm

able 0.6

1

HDPE

carbouy(ByRoad)

Tetrahydro furan 0.48

0.9 0.9 Hazardou

s Non-

Flamm

0.5

2

HDPE

carbouy(ByRoad)


12

able

Triethylamine 0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

Potassium carbonate 0.21

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

sodium borohydride 0.238 0.55

5 0.555

Hazardou

s

Non-

Flamm

able 0.3

4

HDPE

carbouy(ByRoad)

Potassium butoxide 0.449 0.99

9 0.999

Hazardou

s

Non-

Flamm

able 0.4

56

HDPE

carbouy(ByRoad)

Acetone 31

66 66 Hazardou

s

Flamm

able 32

HDPE

carbouy(ByRoad)


0.99 0.99 Hazardou

s

Non-

Flamm

able 0.7

HDPE

carbouy(ByRoad)

Isopropply iodide 0.2

0.4 0.4 Hazardou

s

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Isopropanol 1.73

2.86 2.86 Hazardou

s

Flamm

able 1.9

HDPE

carbouy(ByRoad)


13


2 0.022

Hazardou

s

Non-

Flamm

able 0.0

22

HDPE

carbouy(ByRoad)

Celite 0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

chloroform 3.1

6.2 6.2 Hazardou

s

Non-

Flamm

able 4.2

HDPE

carbouy(ByRoad)

toluene 23

50 50 Hazardou

s

Flamm

able 25

HDPE

carbouy(ByRoad)

Dicycloheylcabdiimide 4.05

8.9 8.9 Hazardou

s

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

phsophoric acid 0.22

0.51 0.51 Hazardou

s

Non-

Flamm

able 0.2

3

HDPE

carbouy(ByRoad)

dimethyl sufoxide 0.16

0.36 0.36 Hazardou

s

Non-

Flamm

able 0.1

9

HDPE

carbouy(ByRoad)

triphenyl-4(-phenyl-3-

oxobutyl) phosphonium iodide

3.84

7.1 7.1 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)


14

Anti-

glaucoma/Antiocu

lar hypertenstion

Bimatoprost

Cyclopentane heptenoice acid,

5-cls-2-(3-αhydroxy-5-phenyl-

1-trans-pentenyl)-3,5

dihydroxy,,[1α,2β,3α,5α] 0.264

0.4 0.4 Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Acetone

7 15 15

Hazardou

s

Flamm

able 15

HDPE

carbouy(ByRoad)

DBU(1,8-Diazabicyclo[5.4.0]

undec-7-ene)

0.1

0.23 0.23 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Methyl iodide

0.1 0.23 0.23

Hazardou

s

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Ethyl Acetate

10.33

22 22 Hazardou

s

Non-

Flamm

able 11.

12

HDPE

carbouy(ByRoad)

Methanol

50.22

105.

1 105.1

Hazardou

s

Flamm

able 60

HDPE

carbouy(ByRoad)

Dimethylamine

0.88

1.6 1.6 Hazardou

s

Non-

Flamm

able 0.9

1

HDPE

carbouy(ByRoad)

silica gel

10

25 25 Hazardou

s

Non-

Flamm

able 11

HDPE

carbouy(ByRoad)


15

Hazardou

s

Non-

Flamm

able

Anti-

glaucoma/Antiocu

lar hypertenstion

Brimonidine

6-amino-5-bromoquinoxaline

hydrobromide

0.4

0.95 0.95 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Thiophosgene

0.12

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

water

35

85 85

Non

Hazardou

s

Non-

Flamm

able 38

Tank NA

carbouy(ByRoad)

Cyclohexane

40 90 90

Hazardou

s

Flamm

able 41

HDPE

carbouy(ByRoad)

Ethylene diamine

0.6

1.5 1.5 Hazardou

s

Non-

Flamm

able 0.6

5

HDPE

carbouy(ByRoad)

Diethyl ether

10 22 22

Hazardou

s

Flamm

able 11

HDPE

carbouy(ByRoad)

Methanol

70 145 145

Hazardou

s

Flamm

able 71.

12

HDPE

carbouy(ByRoad)

Hydrogen sulphide

0.1 0.25 0.25

Hazardou

s Flamm0.1

51

HDPE

carbouy(ByRoad)


16

able

Anti-

glaucoma/Antiocu

lar hypertenstion

Travatoprost

(3aR,4S,5R,6aS)-4-

(hydroxymethyl)-2-

oxohexahydro-2H-

cyclopenta[b]furan-5yl-O.O'-

biphenyl phosphonate 0.45

0.95 0.95 Hazardou

s

Non-

Flamm

able

0.5

HDPE

carbouy(ByRoad)

Dimethyl {2-oxo-3-

(trifluoromethyl)phenoxy]prop

yl}phosphonate 0.36

0.76 0.76 Hazardou

s

Non-

Flamm

able 0.4

1

HDPE

carbouy(ByRoad)

Dimethyl ether

0.28 0.65 0.65

Hazardou

s

Flamm

able 0.3

1

HDPE

carbouy(ByRoad)

Cesium chloride heptahydrate

0.95

1.5 1.5 Hazardou

s

Non-

Flamm

able 0.9

8

HDPE

carbouy(ByRoad)

Methanol

15.6 32 32

Hazardou

s

Flamm

able 21

HDPE

carbouy(ByRoad)

sodium borohydride

0.2

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.2

4

HDPE

carbouy(ByRoad)

Potassium carbonate

0.12

0.24 0.24 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)


17

Diisobutyl alluminium hydride

0.9

1.9 1.9 Hazardou

s

Non-

Flamm

able 0.9

7

HDPE

carbouy(ByRoad)

4-carboxybutyl triphenyl

phosphonium bromide

0.6

1.3 1.3 Hazardou

s

Non-

Flamm

able 0.7

1

HDPE

carbouy(ByRoad)

1,8-Diazabicyclo[5.4.0] undec-

7-ene

0.14

0.3 0.3 Hazardou

s

Non-

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

water

15

32 32

Non

Hazardou

s

Non-

Flamm

able 35

Tank NA

carbouy(ByRoad)

Acetone

16

36 36 Hazardou

s

Non-

Flamm

able 38

HDPE

carbouy(ByRoad)

1-propyl iodide

0.16

0.38 0.38 Hazardou

s

Non-

Flamm

able 0.3

9

HDPE

carbouy(ByRoad)

sodium

methylsulfinylmethylide

0.35

0.78 0.78 Hazardou

s

Non-

Flamm

able 0.7

9

HDPE

carbouy(ByRoad)

16 Dimethyl sulphoxide

0.28 0.68 0.68

Hazardou

s Non-

Flamm

0.6

9

HDPE

carbouy(ByRoad)


18

able

Anti-

glaucoma/Antiocu

lar hypertenstion

Timolol

Toluene

15

35 35 Hazardou

s

Non-

Flamm

able 16

HDPE

carbouy(ByRoad)

Conc. HCL

0.498

0.91 0.91 Hazardou

s

Non-

Flamm

able 0.5

81

HDPE

carbouy(ByRoad)

Water

55

110 110

Non

Hazardou

s

Non-

Flamm

able 60

Tank NA

carbouy(ByRoad)

Sodium Hydroxide

0.132

0.30

4 0.304

Hazardou

s

Non-

Flamm

able 0.1

4

HDPE

carbouy(ByRoad)

Activated Charcoal

0.066

0.11 0.11 Hazardou

s

Non-

Flamm

able 0.0

67

HDPE

carbouy(ByRoad)

Acetone

25 59 59

Hazardou

s

Flamm

able 28

HDPE

carbouy(ByRoad)

Maleic Acid

0.288

0.65

8 0.658

Hazardou

s

Non-

Flamm

able 0.2

98

HDPE

carbouy(ByRoad)


19

Anti-

glaucoma/Antiocu

lar hypertenstion

Dozolamide

14.95

29.1

2 29.12

Hazardou

s

Non-

Flamm

able 15.

1

HDPE

carbouy(ByRoad)

Hydrochloric acid

16.8

35.2

2 35.22

Hazardou

s

Non-

Flamm

able 17.

12

HDPE

carbouy(ByRoad)

n-Butanol

11.6

23.2 23.2 Hazardou

s

Non-

Flamm

able 13.

1

HDPE

carbouy(ByRoad)

Methanol

15.1

32.2

3 32.23

Hazardou

s

Flamm

able 16.

2

HDPE

carbouy(ByRoad)

Ethyl Acetate

7.4

17.1

2 17.12

Hazardou

s

Non-

Flamm

able 7.3

HDPE

carbouy(ByRoad)

Acetone

40

82.3

5 82.35

Hazardou

s

Flamm

able 42

HDPE

carbouy(ByRoad)

(-)Di-para-toluoy-L-tartaric

acid monohydrate

50

102 102 Hazardou

s

Non-

Flamm

able 55

HDPE

carbouy(ByRoad)

Activated Carbon

0.015

0.03 0.03 Hazardou

s

Non-

Flamm

able 0.0

25

HDPE

carbouy(ByRoad)


20

Soduim bicarbonate

0.75

1.5 1.5 Hazardou

s

Non-

Flamm

able 0.7

6

HDPE

carbouy(ByRoad)

Sodium chloride

0.75

1.5 1.5 Hazardou

s

Non-

Flamm

able 0.7

6

HDPE

carbouy(ByRoad)

Sodium hydroxide

1.29

2.3 2.3 Hazardou

s

Non-

Flamm

able 2.0

1

HDPE

carbouy(ByRoad)

water

24

55 55

Non

Hazardou

s

Non-

Flamm

able 26.

1

HDPE

carbouy(ByRoad)

HDPE

carbouy(ByRoad)

Anti-Acidity Omeprazole

2-Chloromethyl-3-methyl-4-

(2,2,2-trifluoroethoxy)Pyridine

Hydrochloride 0.912

1.89 1.89 Hazardou

s

Non-

Flamm

able 1.2

HDPE

carbouy(ByRoad)

2-Mercapto-5-methoxy benz

imidazole (Mercapto

compound) 0.916

1.85

6 1.856

Hazardou

s

Non-

Flamm

able 1.1

HDPE

carbouy(ByRoad)

17 Sodium Hydroxide

0.26

0.56 0.56 Hazardou

s

Non-

Flamm

able 0.2

7

HDPE

carbouy(ByRoad)


21

Methanol 30

65 65 Hazardou

s

Flamm

able 31.

2

HDPE

carbouy(ByRoad)

Water

40

85 85

Non

Hazardou

s

Non-

Flamm

able 45

Tank NA

carbouy(ByRoad)

Hydrogen peroxide

0.95

1.86 1.86 Hazardou

s

Non-

Flamm

able 1.2

5

HDPE

carbouy(ByRoad)

Ammonium molybdate

tetrahydrate 0.15

0.36 0.36 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Sodium carbonate

0.85

1.64 1.64 Hazardou

s

Non-

Flamm

able 0.8

9

HDPE

carbouy(ByRoad)

Acetic Acid

0.156

0.48 0.48 Hazardou

s

Non-

Flamm

able 0.1

65

HDPE

carbouy(ByRoad)

Triethyl amine

0.25

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Dichloro methane

0.256

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.3

56

HDPE

carbouy(ByRoad)


22

Acetone 25

55 55 Hazardou

s

Flamm

able 32

HDPE

carbouy(ByRoad)

19

Anti-Acidity Pantaprazole 2-Chloromethyl-3,4-dimethoxy

pyridine HCL

0.25

0.55 0.55 Hazardou

s

Non-

Flamm

able 0.2

8

HDPE

carbouy(ByRoad)

5-Diffuoromethoxy-2-

mercapto benzimidazole

0.24

0.52 0.52 Hazardou

s

Non-

Flamm

able 0.2

9

HDPE

carbouy(ByRoad)

Acetone 15

32 32 Hazardou

s

Flamm

able 17

HDPE

carbouy(ByRoad)

Hydrogen peroxide (50%)

0.32

0.75 0.75 Hazardou

s

Non-

Flamm

able 0.3

7

HDPE

carbouy(ByRoad)

Isopropyl alcohol 16

35 35 Hazardou

s

Flamm

able 18

HDPE

carbouy(ByRoad)

20 Sodium Hydroxide

0.23

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.2

8

HDPE

carbouy(ByRoad)

Anti-Acidity Rabeprazole 2,3-Lutidine 0.45

0.95 0.95 Hazardou

s Non-

Flamm 0.5

HDPE

carbouy(ByRoad)


23

able

2-Mercapto benzimidazole

0.47 0.94

0.62

0.940.6

2

Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

3-Methoxy-1-Propanol

0.32

0.62 0.62 Hazardou

s

Non-

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

Acetic acid

0.16

0.32 0.32 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Acetic Anhydride

0.365

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Acetone 15

30 30 Hazardou

s

Flamm

able 18

HDPE

carbouy(ByRoad)

Activated carbon

0.025

0.05 0.05 Hazardou

s

Non-

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Ammonium Hydroxide

0.125 0.24

5 0.245

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Hydrochloric acid 0.125 0.24

5 0.245

Hazardou

s Non-

Flamm 0.3

HDPE

carbouy(ByRoad)


24

able

Hydrogen peroxide (50%)

0.33

0.66 0.66 Hazardou

s

Non-

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

Isopropyl Alcohol 30

65 65 Hazardou

s

Flamm

able 35

HDPE

carbouy(ByRoad)

MDC

16.5

32.5 32.5 Hazardou

s

Non-

Flamm

able 17

HDPE

carbouy(ByRoad)

Mono Methyl amine in

methanol

0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Nitric acid

0.14

0.28 0.28 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Sodium Hydro Sulphate

0.12

0.24 0.24 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Sodium Hydroxide

0.23

0.46 0.46 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Sodium Hypochlorite(8%) 1.2

2.4 2.4 Hazardou

s Non-

Flamm 1.5

HDPE

carbouy(ByRoad)


25

able

Sodium sulphate

0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Thionyl Chloride

0.38

0.38 0.38 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Tolunene 13.5

26.5 26.5 Hazardou

s

Flamm

able 15

HDPE

carbouy(ByRoad)

Anti-

inflammatery Ketoprofen

ceba(3,(1,Cyanoethyl)Benzoic

Acid

0.25

0.55 0.55 Hazardou

s

Non-

Flamm

able 0.2

8

HDPE

carbouy(ByRoad)

Benzene

0.437 0.83

5 0.835

Hazardou

s

Non-

Flamm

able 0.4

5

HDPE

carbouy(ByRoad)

Thionyl chloride

0.187 0.26

5 0.265

Hazardou

s

Non-

Flamm

able 0.1

9

HDPE

carbouy(ByRoad)

aluminum Chloride

0.972

5 0.18

5 0.185

Hazardou

s

Non-

Flamm

able 0.9

99

HDPE

carbouy(ByRoad)


26

Hydro chloric acid

0.406

5 0.95 0.95 Hazardou

s

Non-

Flamm

able 0.5

1

HDPE

carbouy(ByRoad)

sodium bicarboante

0.21

0.52 0.52 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Caustic lye

2.25

5.2 5.2 Hazardou

s

Non-

Flamm

able 2.5

6

HDPE

carbouy(ByRoad)

ketoprofen Nitrile

0.225 0.55

2 0.552

Hazardou

s

Non-

Flamm

able 0.4

1

HDPE

carbouy(ByRoad)

caustic soda lye

0.12

0.24 0.24 Hazardou

s

Non-

Flamm

able 0.2

1

HDPE

carbouy(ByRoad)

sulphuric acid

0.155 0.31

5 0.315

Hazardou

s

Non-

Flamm

able 0.2

55

HDPE

carbouy(ByRoad)

Toluene 14

30 30 Hazardou

s

Flamm

able 15

HDPE

carbouy(ByRoad)

Acetic acid

0.66 0.95

6 0.956

Hazardou

s

Non-

Flamm

able 0.6

9

HDPE

carbouy(ByRoad)


27

Hyflo supper cell

0.03 0.06

7 0.067

Hazardou

s

Non-

Flamm

able 0.0

4

HDPE

carbouy(ByRoad)

Activated Charcoal

0.03 0.06

7 0.067

Hazardou

s

Non-

Flamm

able 0.0

45

HDPE

carbouy(ByRoad)

Dexketoprofen Ketoprofen

0.1 0.21

2 0.212

Hazardou

s

Non-

Flamm

able 0.1

2

HDPE

carbouy(ByRoad)

NODG

0.14

0.29 0.29 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Methanol 5.5 10.5

1 10.51

Hazardou

s

Flamm

able 5.6

HDPE

carbouy(ByRoad)

Ethyl Acetate 5.5 10.5

1 10.51

Hazardou

s

Flamm

able 5.6

HDPE

carbouy(ByRoad)

Toluene 20

45 45 Hazardou

s

Flamm

able 21

HDPE

carbouy(ByRoad)

Sodium Hydroxide

0.7

0.98 0.98 Hazardou

s

Non-

Flamm

able 0.8

HDPE

carbouy(ByRoad)


28

22 Water

60

80 80

Non

Hazardou

s

Non-

Flamm

able 85

Tank NA

carbouy(ByRoad)

23 Analgesics Tramadol Cyclohexane 0.04

0.09 0.09 Hazardou

s

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

Dimethyl Amine HCL

0.275

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Paraformaldehyde

0.101

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Acetic Acid

0.08 0.09

6 0.096

Hazardou

s

Non-

Flamm

able 0.0

95

HDPE

carbouy(ByRoad)

C.S Flakes

0.16

0.32 0.32 Hazardou

s

Non-

Flamm

able 0.1

7

HDPE

carbouy(ByRoad)

Toluene 10

25 25 Hazardou

s

Flamm

able 11

HDPE

carbouy(ByRoad)

THF

1.04 2.04

5 2.045

Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)


29

MCA

0.4

0.85 0.85 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

HCL 30%

0.3

0.78 0.78 Hazardou

s

Non-

Flamm

able 0

HDPE

carbouy(ByRoad)

Ammonia 25%

0.55

0.94 0.94 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)


1.5 1.5 Hazardou

s

Flamm

able 0.9

HDPE

carbouy(ByRoad)

24 Activated Carbon

0.08

0.1 0.1 Hazardou

s

Non-

Flamm

able 0.0

95

HDPE

carbouy(ByRoad)

Hazardou

s

Anticonvulsant/an

tiepileptic drug Phenytoin Benzil

0.3

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Urea

0.36

0.76 0.76 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Caustic lye 0.2 0.45 0.45 HazardouNon-

Flamm 0.2 HDPE


30

s able 5 carbouy(ByRoad)

Hydrochloric Acid

0.2

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Methanol 6.8

15.5 15.5 Hazardou

s

Flamm

able 7.1

HDPE

carbouy(ByRoad)

Hyflow

0.01

0.05 0.05 Hazardou

s

Non-

Flamm

able 0.0

11

HDPE

carbouy(ByRoad)

Sodium Hydroxide

0.8

0.15 0.15 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

Activated Carbon

0.02 0.04

5 0.045

Hazardou

s

Non-

Flamm

able 0.0

25

HDPE

carbouy(ByRoad)

Anti-convulsant Phenytoin sodium Benzil

0.3

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Urea

0.36

0.76 0.76 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)


31

Caustic lye

0.2

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Hydrochloric Acid

0.2

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Methanol 6.8

15.5 15.5 Hazardou

s

Flamm

able 7.1

HDPE

carbouy(ByRoad)

Soduim hydroxide

0.01

0.05 0.05 Hazardou

s

Non-

Flamm

able 0.0

11

HDPE

carbouy(ByRoad)

25 Hyflow

0.08

0.15 0.15 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

Anti-convulsant Fosphenytoin Sodium phonytoin

0.25

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.2

6

HDPE

carbouy(ByRoad)

HCL

0.17

0.35 0.35 Hazardou

s

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

K2CO3 0.01

0.02 0.02 Hazardou

s Non-

Flamm

0.0

2

HDPE

carbouy(ByRoad)


32

able

HCHO

0.5

0.94 0.94 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

SDS

0.144 0.28

5 0.285

Hazardou

s

Non-

Flamm

able 0.1

9

HDPE

carbouy(ByRoad)

Thionyl Chloride

0.15

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

6

HDPE

carbouy(ByRoad)

DMF 0.123 0.23

6 0.236

Hazardou

s

Flamm

able 0.1

25

HDPE

carbouy(ByRoad)

NaHCO3

0.25

0.55 0.55 Hazardou

s

Non-

Flamm

able 0.2

9

HDPE

carbouy(ByRoad)

EtOAC

0.36

0.71 0.71 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Anti-maleria Artesunate Di-Hydro Artemisinin

0.29

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)


33

26 Acetone 1.5

2.9 2.9 Hazardou

s

Flamm

able 1.8

HDPE

carbouy(ByRoad)

Succinic Acid

0.3

0.7 0.7 Hazardou

s

Non-

Flamm

able 0.4

5

HDPE

carbouy(ByRoad)

Catalyst

0.011 0.02

5 0.025

Hazardou

s

Non-

Flamm

able 0.0

22

HDPE

carbouy(ByRoad)

Activated Carbon

0.02 0.04

5 0.045

Hazardou

s

Non-

Flamm

able 0.0

25

HDPE

carbouy(ByRoad)

Antihistaminic Oxytocin

29

30 AntiFungal/Antibi

otics Amphotericin

Hazardou

s

HDPE

carbouy(ByRoad)

31 Anti-Viral Ganciclovir

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)


34

32 Anti-erectile

dysfuncation Alprostadil

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Anti-hypertensive Hydralazine hcl Phthalazinone

0.253 0.56

7 0.567

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Phosphorous Oxychloride

0.157

0.36 0.36 Hazardou

s

Non-

Flamm

able 0.1

7

HDPE

carbouy(ByRoad)

Dichloromethane

2

4.5 4.5 Hazardou

s

Non-

Flamm

able 2.1

HDPE

carbouy(ByRoad)

Hydrazine Hydrate

0.172 0.25

7 0.257

Hazardou

s

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

Isopropanol 1.5

2.6 2.6 Hazardou

s

Flamm

able 2

HDPE

carbouy(ByRoad)

Methanol 5.2

10.5 10.5 Hazardou

s

Flamm

able 5.5

HDPE

carbouy(ByRoad)

Hydrochloric Acid

0.189

0.31 0.31 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)


35

Norit charcoal DX-Ultra

0.024

8 0.04

5 0.045

Hazardou

s

Non-

Flamm

able 0.0

52

HDPE

carbouy(ByRoad)

Hyflow

0.024

8 0.04

5 0.045

Hazardou

s

Non-

Flamm

able 0.0

52

HDPE

carbouy(ByRoad)

Aqueous ammonia

0.224 0.55

1 0.551

Hazardou

s

Non-

Flamm

able 0.5

24

HDPE

carbouy(ByRoad)

34 Anti-convulsant Vecuronium bromide Vecuronium Diol

0.25

0.61 0.61 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Acetic an hydride

0.194 0.21

4 0.214

Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

MDC

0.1

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Acetonitrile

0.1

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

MTBE 0.2 0.45 0.45 HazardouNon-

Flamm 0.2 HDPE


36


Water

8

19 19

Non

Hazardou

s

Non-

Flamm

able 10

Tank

NAcarbouy(ByRo

ad)

Methyl bromide

0.1

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Ethyl Acetate 0.1

0.25 0.25 Hazardou

s

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Diethyl ether 0.1

0.25 0.25 Hazardou

s

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Anti-convulsant Rocuronium bromide Rocuronium diol

0.258 0.58

4 0.584

Hazardou

s

Non-

Flamm

able 0.2

9

HDPE

carbouy(ByRoad)

1-Imidazole-1-yl-ethanone

0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

9

HDPE

carbouy(ByRoad)

Ethyl Acetate 0.15

0.35 0.35 Hazardou

s

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Acetonitrile 0.125 0.25

4 0.254

Hazardou

s Non-

Flamm 0.2

HDPE

carbouy(ByRoad)


37

able

Methylene dichloride 0.15

0.39 0.39 Hazardou

s

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Hyflow

0.02

0.05 0.05 Hazardou

s

Non-

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Activated Carbon

0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

Pet ether

0.12

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

3-Bromo -propene

0.11

0.12 0.12 Hazardou

s

Non-

Flamm

able 0.1

2

HDPE

carbouy(ByRoad)

Ethyl acetate

0.13

0.28 0.28 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Methylene dichloride

0.13

0.28 0.28 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Water 8

17 17 Hazardou

s Non-

Flamm 10

HDPE

carbouy(ByRoad)


38

able

Diethyl ether 0.12

0.25 0.25 Hazardou

s

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

35 Methylene chloride 0.12

0.25 0.25 Hazardou

s

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Antibiotic Vancomycin hcl Vancomycin(Base)

0.31

0.36 0.36 Hazardou

s

Non-

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

Water

11

25 25

Non

Hazardou

s

Non-

Flamm

able 12

Tank NA

carbouy(ByRoad)

Hydrochloric Acid(35%)

0.3

0.7 0.7 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Antibiotic Chloramphenicol sod

succinate

Chloramphenicol Hemi

succinate

0.36

0.75 0.75 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Ethyl Acetate 0.245

0.45 0.45 Hazardou

s

Flamm

able 0.3

HDPE

carbouy(ByRoad)


39

Succinic Anhydride 2.625

4.5 4.5 Hazardou

s

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)

Tri sodium Phosphate 0.357

0.65 0.65 Hazardou

s

Non-

Flamm

able 0

HDPE

carbouy(ByRoad)

Mono Ethyl Amine 1.946

2.1 2.1 Hazardou

s

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

Thinner 0.592 0.94

5 0.945

Hazardou

s

Flamm

able 0.6

HDPE

carbouy(ByRoad)

HCL 0.28

0.48 0.48 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

36

EDTA 0.1

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

37


1.67 1.67 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

38 Antibiotic Clindamycin Lincomycin HCL

0.111

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

2

HDPE

carbouy(ByRoad)


40

chloroform

0.142

0.23 0.23 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

DMF 0.03

0.06 0.06 Hazardou

s

Flamm

able 0.0

4

HDPE

carbouy(ByRoad)

Thionyl Chloride

0.115 0.22

5 0.225

Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Sodium hydroxide

0.1

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

2

HDPE

carbouy(ByRoad)

MDC

0.08

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

9

HDPE

carbouy(ByRoad)

Ethanol 0.1

0.25 0.25 Hazardou

s

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

HCL

0.14

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Charcoal

0.01

0.02 0.02 Hazardou

s

Non-

Flamm

able 0.0

15

HDPE

carbouy(ByRoad)

Acetone 0.12 0.24 0.24 Hazardou Flamm 0.1 HDPE


41


39 Anti-shingles

infection Aciclovir sodium 1,3-dioxolane

0.21

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Acetic anhydride

0.35

0.75 0.75 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

sulphuric acid

0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

Guanidine HCL

0.128

0.24 0.24 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Acetyl chloride

0.107

5 0.2 0.2 Hazardou

s

Non-

Flamm

able 0.2

1

HDPE

carbouy(ByRoad)

Potassium carbonate

0.141

0.28 0.28 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Acetone 5

10 10 Hazardou

s

Flamm

able 7

HDPE

carbouy(ByRoad)


42

Toluene 9

18 18 Hazardou

s

Flamm

able 10

HDPE

carbouy(ByRoad)

Water

6

12 12

Non

Hazardou

s

Non-

Flamm

able 7

Tank NA

carbouy(ByRoad)

PTSA

0.2

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)


2.35 2.35 Hazardou

s

Flamm

able 2

HDPE

carbouy(ByRoad)

Sodium sulphate

0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

9

HDPE

carbouy(ByRoad)

Methanol 7.25

14.5 14.5 Hazardou

s

Flamm

able 8

HDPE

carbouy(ByRoad)

Sodium Hydroxide

0.46

0.98 0.98 Hazardou

s

Non-

Flamm

able 0.5

1

HDPE

carbouy(ByRoad)

Activated Carbon

0.05

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

7

HDPE

carbouy(ByRoad)

Hyflow 0.02

0.09 0.09 Hazardou

s Non-

Flamm

0.0

25

HDPE

carbouy(ByRoad)


43

able

40 Analgesics Paracetamol

Para-amino phenol 134.8 269.

6 269.6

Hazardou

s

Non-

Flamm

able 135

HDPE

carbouy(ByRoad)

Acetic Anhydride 126.2 252.

4 252.4

Hazardou

s

Non-

Flamm

able 128

HDPE

carbouy(ByRoad)

Zinc 0.002 0.00

4 0.004

Hazardou

s

Non-

Flamm

able 0.0

05

HDPE

carbouy(ByRoad)

Ethylene Diamine Tetre Acetic

Acid (EDTA) 0.06 0.12 0.12

Hazardou

s

Non-

Flamm

able 0.0

7

HDPE

carbouy(ByRoad)

Soda ash 0.02 0.04 0.04 Hazardou

s

Non-

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

Activated Carbon 0.1 0.2 0.2 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Hydrous 0.004 0.00 0.008 Hazardou Non- 0.0 HDPE


44

8 s Flamm

able

05 carbouy(ByRoad)

41

42 Anti-Cancer ALPHA LINOLENIC

ACID (ALA) Ethyl-6,8-dioctanoate

0.9 1.8 1.8 Hazardou

s

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)

Ethanol

0.16 0.35 0.35 Hazardou

s

Flamm

able 0.1

9

HDPE

carbouy(ByRoad)

Conc.HCL

0.045 0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

Toluene

3.5 7.1 7.1 Hazardou

s

Flamm

able 4

HDPE

carbouy(ByRoad)

Water

6 15 15

Non

Hazardou

s

Non-

Flamm

able 7

Tank NA

carbouy(ByRoad)

Sodium sulphide

0.565 11 11 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Sulphur

0.118 0.22

8 0.228

Hazardou

s

Non-

Flamm

able 0.1

19

HDPE

carbouy(ByRoad)


45

TBAB

0.037 0.06

6 0.066

Hazardou

s

Non-

Flamm

able 0.0

4

HDPE

carbouy(ByRoad)

Potassium Hydroxide

0.236 0.45 0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium Chloride

0.3 0.36 0.36 Hazardou

s

Non-

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

Ethyl Acetate

0.33 0.66 0.66 Hazardou

s

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

Cyclohexane

0.41 0.48 0.48 Hazardou

s

Flamm

able 0.4

5

HDPE

carbouy(ByRoad)

Activated Charcoal

0.09 0.09

8 0.098

Hazardou

s

Non-

Flamm

able 0.1

HDPE

carbouy(ByRoad)

43 Build protins and

proteins are life AMINO ACID ALL

TYPES (L-SERIES)

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)


46

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Anti-Maleria Arteether

Di-Hydro Artemisinin

0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Toluene

0.5 0.12 0.12

Hazardou

s

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Sodium Ethoxide

0.133

0.15 0.15 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Catalyst

0.012 0.01

5 0.015

Hazardou

s Non-

Flamm

0.0

15

HDPE

carbouy(ByRoad)


47

able

Activated Charcoal

0.024

0.03 0.03 Hazardou

s

Non-

Flamm

able 0.0

25

HDPE

carbouy(ByRoad)

Anti-Maleria Artemether

Di-Hydro Artemisinin

0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Toluene

0.5 0.12 0.12

Hazardou

s

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Sodium Methoxide

0.133

0.15 0.15 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Catalyst

0.01 0.01

5 0.015

Hazardou

s

Non-

Flamm

able 0.0

15

HDPE

carbouy(ByRoad)

Activated Carbon

0.024

0.03 0.03 Hazardou

s

Non-

Flamm

able 0.0

25

HDPE

carbouy(ByRoad)

###

#


48

###

#

Anticholinesterase

/Anticonvulsant

ATRACURONIUM

BROMIDE

###

#

Anti-

glaucoma/Antiocu

lar hypertenstion

Brinzolomide Thiourea

0.196 0.25

6 0.256

Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Benzyl chloride

0.311 0.64

2 0.642

Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Ethanol 2.51

4.12 4.12 Hazardou

s

Flamm

able 3

HDPE

carbouy(ByRoad)

3-acetyl -2,5-

Dichlorothiophene

0.456 0.84

5 0.845

Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

5.4 M aqueous Sodium

hydrochloride

0.151


s

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

5.25% sodium hypochlorite

0.456

0.85 0.85 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

2-propanol 0.152

0.32 0.32 Hazardou

s

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)


49

Water

17.3

35 35

Non

Hazardou

s

Non-

Flamm

able 18

Tank

NAcarbouy(ByRo

ad)

3-acetyl-5-chloro-2-

(benzylthio)thiophene

0.638

0.15 0.15 Hazardou

s

Non-

Flamm

able 0.7

3

HDPE

carbouy(ByRoad)

Sodium tungstate dihydrate

0.137

0.26 0.26 Hazardou

s

Non-

Flamm

able 0.1

35

HDPE

carbouy(ByRoad)

30%Hydrogen peroide

0.14

0.28 0.28 Hazardou

s

Non-

Flamm

able 0.2

8

HDPE

carbouy(ByRoad)

Sodium bisulfite

0.28

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Aaqueous sodium bicarbonate

0.135 0.26

3 0.263

Hazardou

s

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Saturated aqueous sodium

chloride

0.123


s

Non-

Flamm

able 0.2

4

HDPE

carbouy(ByRoad)

t-butyl methyl ether 0.187

0.36 0.36 Hazardou

s Non-

Flamm

0.3

6

HDPE

carbouy(ByRoad)


50

able

Sodium sulfate

0.06 0.01

2 0.012

Hazardou

s

Non-

Flamm

able 0.0

12

HDPE

carbouy(ByRoad)

3-acetyl-5-chlor-2-

thiophenesulfonamid

0.063

1 0.09

9 0.099

Hazardou

s

Non-

Flamm

able 0.0

8

HDPE

carbouy(ByRoad)

sodium bicarboante

0.01 0.02

5 0.025

Hazardou

s

Non-

Flamm

able 0.0

2

HDPE

carbouy(ByRoad)

Magnesium sulphate

0.02 0.02

5 0.025

Hazardou

s

Non-

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

Methylene chloride 0.123 0.24

3 0.243

Hazardou

s

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

Acetonitrile

0.164

0.35 0.35 Hazardou

s

Non-

Flamm

able 0.3

5

HDPE

carbouy(ByRoad)

Trimethylorthoacetate

26.2

42.2 42.2 Hazardou

s

Non-

Flamm

able 52.

4

HDPE

carbouy(ByRoad)

Tetrahydrofuran 0.095 0.09

9 0.099

Hazardou

s Non-

Flamm 0.1

HDPE

carbouy(ByRoad)


51

able

Hydrochloric Acid

12.12


s

Non-

Flamm

able 15

HDPE

carbouy(ByRoad)

Triethylamine 15.98 30.1

2 30.12

Hazardou

s

Flamm

able 16

HDPE

carbouy(ByRoad)

70% aqueous ethylamine

12.47

7 25.3

1 25.31

Hazardou

s

Non-

Flamm

able 15

HDPE

carbouy(ByRoad)

1M aqueous hydrochloride

acid

8.12 13.0

12 13.012

Hazardou

s

Non-

Flamm

able 9

HDPE

carbouy(ByRoad)

p-toluenesulfonyl chloride

0.12

0.24 0.24 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Sodium bicarbonate

0.045

0.09 0.09 Hazardou

s

Non-

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

###

# Anti-Diabetic Canagliflozin

2-(5-bromo-2-methyl benzul)-

5-(4-Flurophenyl)thiophene

0.25

0.52 0.52 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)


52

Sily D-gloconolactone

0.25

0.52 0.52 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Methanol 12

24 24 Hazardou

s

Flamm

able 13

HDPE

carbouy(ByRoad)

Acetone 10

20 20 Hazardou

s

Flamm

able 11

HDPE

carbouy(ByRoad)

Potassium Carbonate

0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Water

11

23 23

Non

Hazardou

s

Non-

Flamm

able 12

Tank NA

carbouy(ByRoad)

###

# Anti-biotic CAPREOMYCIN

SULPHATE Bacto Peptone

4.17

9 9 Hazardou

s

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

Casamino acid

2.08

4.5 4.5 Hazardou

s

Non-

Flamm

able 2.5

HDPE

carbouy(ByRoad)

Cerelose

1.25

2.5 2.5 Hazardou

s

Non-

Flamm

able 1.3

HDPE

carbouy(ByRoad)


53

Magnesium sulphate

1.26

2.5 2.5 Hazardou

s

Non-

Flamm

able 1.3

HDPE

carbouy(ByRoad)

Ferrous sulphate

0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Ethyl Acetate

2.917 4.9 4.9

Hazardou

s

Flamm

able 3

HDPE

carbouy(ByRoad)

Calcium Chloride

0.21

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

n-Heptane

0.75 1.75 1.75

Hazardou

s

Flamm

able 0.8

HDPE

carbouy(ByRoad)

Antihypotensive Carvedilol

1,3-Cyclohexanedione 4 8 8 Hazardou

s

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

2-Methoxy Phenol 3.4 6.8 6.8 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

chloroacetonitrile 2.21 4.42 4.42 HazardouNon-

Flamm3

HDPE


54


Epichlorohydrin 2.9 5.8 5.8 Hazardou

s

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)

Hydrogen 0.15 0.3 0.3 Hazardou

s

Flamm

able 1

HDPE

carbouy(ByRoad)

Hyflo 0.125 0.25 0.25 Hazardou

s

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)

Isopropyl Alcohol 15 30 30 Hazardou

s

Flamm

able 16

HDPE

carbouy(ByRoad)

Methanol 83.6 167.

2 167.2

Hazardou

s

Flamm

able 84

HDPE

carbouy(ByRoad)

Palladium Carbon 0.85 1.7 1.7 Hazardou

s

Non-

Flamm

able 9

HDPE

carbouy(ByRoad)

Phenyl hydrazine

hydrochloride 5 10 10

Hazardou

s

Non-

Flamm

able 6

HDPE

carbouy(ByRoad)

Sodium Hydroxide 0.197 0.39

4 0.394

Hazardou

s

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)


55

sulfuric Acid 1.75 3.5 3.5 Hazardou

s

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Toluene 174 348 348 Hazardou

s

Flamm

able 175

HDPE

carbouy(ByRoad)

###

#

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

###

# Anti-infection

Ciprofloxacin HCL

Monohydrate Q-Acid

28

61 61 Hazardou

s

Non-

Flamm

able 30

HDPE

carbouy(ByRoad)

Piperazine

11

25 25 Hazardou

s

Non-

Flamm

able 12

HDPE

carbouy(ByRoad)

Sodium hydroxideFlakes

7

14 14 Hazardou

s

Non-

Flamm

able 8

HDPE

carbouy(ByRoad)

Acetic acid

5.7

11 11 Hazardou

s

Non-

Flamm

able 6

HDPE

carbouy(ByRoad)

Hydrochloric Acid

3.3

7.1 7.1 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)


56

n-Butanol 40

82 82 Hazardou

s

Flamm

able 45

HDPE

carbouy(ByRoad)

Methanol 30

61 61 Hazardou

s

Flamm

able 30

HDPE

carbouy(ByRoad)

Activated Carbon

0.005 0.02

5 0.025

Hazardou

s

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)

Water

65

85 85

Non

Hazardou

s

Non-

Flamm

able 70

Tank NA

carbouy(ByRoad)

Antihypotensive

CLONIDINE HCL

2,6-Dichloroaniline 0.253 0.56

2 0.562

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Acetic anhydride 0.25 0.58

6 0.586

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Formic acid 0.74

0.96 0.96 Hazardou

s

Non-

Flamm

able 0.8

HDPE

carbouy(ByRoad)

DM water 45

95 95 Hazardou

s Non-

Flamm 50

HDPE

carbouy(ByRoad)


57

able

Thionyl chloride 0.23

0.46 0.46 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)


1.5 1.5 Hazardou

s

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)

Sulfuryl Chloride 0.24 0.58

6 0.586

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Dimethyl Formamide 0.23 0.53

6 0.536

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium Chloride 0.24 0.54

8 0.548

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Ethylene diamine 0.45

0.95 0.95 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

IPA HCL 80

160 160 Hazardou

s

Non-

Flamm

able 85

HDPE

carbouy(ByRoad)

Methanol 105 125 125 Hazardou Non- 110 HDPE


58

s Flamm

able

carbouy(ByRoad)


8 0.058

Hazardou

s

Non-

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Hyflow 0.02 0.05

8 0.058

Hazardou

s

Non-

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Isopropanol 85

162 162 Hazardou

s

Non-

Flamm

able 90

HDPE

carbouy(ByRoad)

Antithrombotic clopidrogel hydrogen

sulfate

2-(2-Chirorphenyl)

glycine.HCL 6.08

12.1

6 12.16

Hazardou

s

Non-

Flamm

able 7

HDPE

carbouy(ByRoad)

2-Thiophere-2yl ethanol 3.6 7.2 7.2 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

4-Methyl benzene sulfonyl

Chloride 5.36

10.7

2 10.72

Hazardou

s

Non-

Flamm

able 6

HDPE

carbouy(ByRoad)


59

Acetone 40 80 80 Hazardou

s

Flamm

able 45

HDPE

carbouy(ByRoad)

Cyclohexane 104 208 208 Hazardou

s

Flamm

able 105

HDPE

carbouy(ByRoad)

Ethyl Acetate 32 64 64 Hazardou

s

Flamm

able 35

HDPE

carbouy(ByRoad)

Formaldehyde (40%) 4 8 8 Hazardou

s

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

Hydrochloric Acid (35%) 3.44 6.88 6.88 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

L(+) Tartaric Acid 3.36 6.72 6.72 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

Mathanol 20 40 40 Hazardou

s

Flamm

able 25

HDPE

carbouy(ByRoad)

Sodium Bicarbonate 20.96 41.9

2 41.92

Hazardou

s

Non-

Flamm

able 21

HDPE

carbouy(ByRoad)

Soduim Hydroxide 3.2 6.4 6.4 Hazardou

s Non-

Flamm 4

HDPE

carbouy(ByRoad)


60

able

Sulfuric Acid 16 32 32 Hazardou

s

Non-

Flamm

able 17

HDPE

carbouy(ByRoad)

ThionylChloride 6.54 13.1

2 13.12

Hazardou

s

Non-

Flamm

able 7

HDPE

carbouy(ByRoad)

Toluene 25.2 50.4 50.4 Hazardou

s

Flamm

able 26

HDPE

carbouy(ByRoad)

Triethylamine 2.88 5.76 5.76 Hazardou

s

Flamm

able 3

HDPE

carbouy(ByRoad)

###

#

###

# Anti infection

COLISTIN SULPHATE

Colistin sulphate

0.33

0.66 0.66 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

sodium bicarbonate

0.67

0.97 0.97 Hazardou

s

Non-

Flamm

able 0.7

HDPE

carbouy(ByRoad)

Sodium carbonate

0.33

0.66 0.66 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)


61

Formaldehyde 133

266 266 Hazardou

s

Flamm

able 135

HDPE

carbouy(ByRoad)

Sodium bisulfite

0.36

0.76 0.76 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Acetic Acid

0.16

0.26 0.26 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Acetone 15

30 30 Hazardou

s

Flamm

able 16

HDPE

carbouy(ByRoad)

Methanol 25

52 52 Hazardou

s

Flamm

able 26

HDPE

carbouy(ByRoad)

Anti-Diabetic Dapagliflozin 4-Bromo-1-chloro-2-(4-ethoxy

benzyl)benzene

0.7

1.4 Hazardou

s

Non-

Flamm

able 0.8

HDPE

carbouy(ByRoad)

Acetonitrile

0.4

0.8 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Cyclohexane 0.19

0.58 Hazardou

s

Flamm

able 0.2

HDPE

carbouy(ByRoad)


62

Gluconolacotone

0.45

0.9 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Isopropyl Acetate 80

95 Hazardou

s

Flamm

able 85

HDPE

carbouy(ByRoad)

Methanesulfonic acid

0.58

0.99 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Methanol 80

98 Hazardou

s

Flamm

able 90

HDPE

carbouy(ByRoad)

Sodium Bicarbonate

0.22

0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium Chloride

0.24

0.48 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium Dihydrogen Phosphate

0.2

0.4 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Tetrahydrofuran

0.35

0.7 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Trimethylsilyl Chloride 0.242 0.45 Hazardou Flamm 0.3 HDPE


63

8 s able carbouy(ByRoad)

Toluene 62

92 Hazardou

s

Flamm

able 65

HDPE

carbouy(ByRoad)

Triethylsilane 0.42

0.98 Hazardou

s

Flamm

able 0.4

5

HDPE

carbouy(ByRoad)

Methylene Dichloride 85

110 Hazardou

s

Flamm

able 90

HDPE

carbouy(ByRoad)

n-Butyllithium (20%) in

Hexane

19.8 25.3

Hazardou

s

Flamm

able 20

HDPE

carbouy(ByRoad)

n-Hexane 0.14

0.28 Hazardou

s

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

n-Methylmorpholine

0.252 0.56

8

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

anti-congestive

heart failure

/Anti-increase

cardiac output.

DOBUTAMINE Homovetraylamine

0.256 0.52

3 0.523

Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Para anisyl acetone

0.12

0.24 0.24 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)


64

Hydrochloric acid

0.25

0.52 0.52 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium Borohydride

0.58

0.93 0.93 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Methanol 19.4

25 25 Hazardou

s

Flamm

able 20

HDPE

carbouy(ByRoad)

Tolunene 72.9

92 92 Hazardou

s

Flamm

able 80

HDPE

carbouy(ByRoad)

Water

50

75 75

Non

Hazardou

s

Non-

Flamm

able 52

Tank NA

carbouy(ByRoad)

Sodium hydroxide

0.64

1.5 1.5 Hazardou

s

Non-

Flamm

able 0.7

HDPE

carbouy(ByRoad)

Acetone 85

95 95 Hazardou

s

Flamm

able 86

HDPE

carbouy(ByRoad)

Activated Carbon

0.02

0.04 0.04 Hazardou

s

Non-

Flamm

able

0.0

3

HDPE

carbouy(ByRoad)

Hyflow 0.02

0.05 0.05 Hazardou

s Non-

Flamm

0.0

3

HDPE

carbouy(ByRoad)


65

able

Aluminum Chloride

0.23

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Anti-shock

syndrome (anti-

herat attack

,trauma, heart

failure , kidney

failure)

DOPAMINE

HYDROCHLORIDE

3,4-Dimethoxyphenyl

Acetonitrile

0.64

0.98 0.98 Hazardou

s

Non-

Flamm

able

0.7

HDPE

carbouy(ByRoad)

Ammonium hydrochloride

0.13

0.26 0.26 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Hydrogen 0.01

0.02 0.02 Hazardou

s

Flamm

able 0.0

2

Cyclinder

carbouy(ByRoad)

Water

45

90 90

Non

Hazardou

s

Non-

Flamm

able 50

Tank NA

carbouy(ByRoad)

Toluene 47

98 98 Hazardou

s

Flamm

able 50

HDPE

carbouy(ByRoad)

Raney-Nickel 0.08

0.16 0.16 Hazardou

s Non-

Flamm

0.0

9

HDPE

carbouy(ByRoad)


66

able

Hyflow

0.03

0.06 0.06 Hazardou

s

Non-

Flamm

able 0.0

4

HDPE

carbouy(ByRoad)

Hydrochloric Acid

0.22

0.45 0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Isopropyl Alcohol (IPA) 10

22 22 Hazardou

s

Flamm

able 20

HDPE

carbouy(ByRoad)

Sodium hyroxide

0.74

0.94 0.94 Hazardou

s

Non-

Flamm

able 0.8

HDPE

carbouy(ByRoad)

Anti-

glaucoma/Antiocu

lar hypertenstion

Dorzolamide HCL

(±)-Trans-5,6-dihydro-4H-4-

Ethyl amino-6-

methylthieno(2,3-b) thiopyran-

2-sulfonamide-7,7-dioxide

0.266

0.56 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Hydrochloric acid

0.23

0.45 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

n-Butanol 25

52 Hazardou

s

Flamm

able 30

HDPE

carbouy(ByRoad)

Methanol 36 75 Hazardou Flamm 40 HDPE


67


Ethyl Acetate 23

49 Hazardou

s

Flamm

able 25

HDPE

carbouy(ByRoad)

Acetone 55

98 Hazardou

s

Flamm

able 60

HDPE

carbouy(ByRoad)

(-)Di-para-toluoy-L-tartaric

acid monohydrate

0.253 0.56

3

Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Activated Carbon

0.02 0.04

5

Hazardou

s

Non-

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Soduim bicarbonate

0.25

0.5 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium chloride

0.23

0.54 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium hydroxide

0.23

0.53 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

water

56

95

Non

Hazardou

s

Non-

Flamm 58

Tank

NA(ByRoad)


68

able

Anti-tussive Esomeprazole magnesium

dihydrate

5-Methoxy-2-[[(4-methoxy-

3,5-dimethylpyridine-2-

yl)methyl]H-benzimidazole

1.201

2.5 2.5 Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

Hydrogen peroxide

1.24

2.5 2.5 Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

Vanadium acetyl acetone

0.3

0.6 0.6 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Sodium hydroxide

0.2

0.4 0.4 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Acetone 26

55 55 Hazardou

s

Flamm

able 28

HDPE

carbouy(ByRoad)

Methanol 52

105 105 Hazardou

s

Flamm

able 55

HDPE

carbouy(ByRoad)

Acetic acid

0.3

0.6 0.6 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)


69

Ammonia liquor

0.15

0.3 0.3 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

water

50

98 98 NonHaza

rdous

Non-

Flamm

able 55

Tank NA

carbouy(ByRoad)

(+)-Omeprazole

8.54

18.3 18.3 Hazardou

s

Non-

Flamm

able 9

HDPE

carbouy(ByRoad)

Magnesium Chloride

1.17

2.3 2.3 Hazardou

s

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Water

56

98.3 98.3

Non

Hazardou

s

Non-

Flamm

able 58

Tank NA

carbouy(ByRoad)

Methylene chloride (MDC) 40

85 85 Hazardou

s

Flamm

able 42

HDPE

carbouy(ByRoad)

Acetone 30

60 60 Hazardou

s

Flamm

able 32

HDPE

carbouy(ByRoad)

(S)-(-)-11,1-Bi-2-Naphthol

10

20 20 Hazardou

s

Non-

Flamm

able 20

HDPE

carbouy(ByRoad)


70

soduim hydroxide

0.53

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Toluene 60

90 90 Hazardou

s

Flamm

able 65

HDPE

carbouy(ByRoad)

Methanol 56

95 95 Hazardou

s

Flamm

able 60

HDPE

carbouy(ByRoad)

Anti-migraine Fentanyl citrate 1-Benzyl-4-piperidone

0.78

1.5 1.5 Hazardou

s

Non-

Flamm

able 0.8

HDPE

carbouy(ByRoad)

Aniline

0.18

0.36 0.36 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Toluene 25

50 50 Hazardou

s

Flamm

able 26

HDPE

carbouy(ByRoad)

Methanol 20

40 40 Hazardou

s

Flamm

able 21

HDPE

carbouy(ByRoad)

Sodium Borohydride

0.07 0.01

4 0.014

Hazardou

s

Non-

Flamm

able 0.0

8

HDPE

carbouy(ByRoad)

HCL 0.45 0.9 0.9 HazardouNon-

Flamm5

HDPE


71


Liquor Ammonia

0.25

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Propionic anhydride

0.28

0.49 0.49 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium Chloride

0.23

0.46 0.46 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Sodium hydride

0.05

0.1 0.1 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

N-(1-benzylpiperidin-4-yl)-N-

phenylpropanamide

0.4

0.8 0.8 Hazardou

s

Non-

Flamm

able 0

HDPE

carbouy(ByRoad)

Phenylethyl bromide

0.25

0.56 0.56 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Sodium bicarbonate

0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)


72

Potassium carbonate

0.24

0.48 0.48 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Activated Carbon

0.004 0.00

8 0.008

Hazardou

s

Non-

Flamm

able 0.0

05

HDPE

carbouy(ByRoad)

Methanol 1.04

2.04 2.04 Hazardou

s

Flamm

able 2.0

4

HDPE

carbouy(ByRoad)

Isopropyl Alcohol 1.25

2.01 2.01 Hazardou

s

Flamm

able 2.2

5

HDPE

carbouy(ByRoad)

Citric acid

0.19

0.38 0.38 Hazardou

s

Non-

Flamm

able 0.3

8

HDPE

carbouy(ByRoad)

Dimethylformamide 1.66 2.36

6 2.366

Hazardou

s

Flamm

able 2.6

6

HDPE

carbouy(ByRoad)

1 Anti-anemia FERROUS ASCORBATE Ascorbic acid

1.6

3.6 3.6 Hazardou

s

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Ferrous sulphate

1.432

2.9 2.9 Hazardou

s

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)


73

Calcium Carbonate

1.4

2.8 2.8 Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

DM Water

18

36 36

Non

Hazardou

s

Non-

Flamm

able 19

Tank NA

carbouy(ByRoad)

Calcium sulfate (Gypsum)

3.85

6.8 6.8 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

2 Antihistamine Fexafenadine

Hydrochloride

4-(4-Chloro-1-oxobutyl)-α,α-

dimethyl phenyl acetate 91 182 182 Hazardou

s

Non-

Flamm

able 92

HDPE

carbouy(ByRoad)

Acetic acid 5 10 10 Hazardou

s

Non-

Flamm

able 6

HDPE

carbouy(ByRoad)

Acetone 500 1000 1000 Hazardou

s

Flamm

able 550

HDPE

carbouy(ByRoad)

Activated carbon 12 24 24 Hazardou

s

Non-

Flamm

able 13

HDPE

carbouy(ByRoad)


74

Azacyclonol 86 172 172 Hazardou

s

Non-

Flamm

able 90

HDPE

carbouy(ByRoad)

Ethanol 500 1000 1000 Hazardou

s

Flamm

able 550

HDPE

carbouy(ByRoad)

Ethyl Acetate 800 1600 1600 Hazardou

s

Flamm

able 820

HDPE

carbouy(ByRoad)

Hydrochloric acid (35%) 140 280 280 Hazardou

s

Non-

Flamm

able 145

HDPE

carbouy(ByRoad)

Hyflo 10 20 20 Hazardou

s

Non-

Flamm

able 20

HDPE

carbouy(ByRoad)

Methanol 800 1600 1600 Hazardou

s

Flamm

able 900

HDPE

carbouy(ByRoad)

Methyl Isobutyl Ketone 385 770 770 Hazardou

s

Non-

Flamm

able 400

HDPE

carbouy(ByRoad)

Potassium Bicarbonate 50 100 100 Hazardou

s

Non-

Flamm

able 56

HDPE

carbouy(ByRoad)

Potassium Iodide 5 10 10 Hazardou

s Non-

Flamm 6

HDPE

carbouy(ByRoad)


75

able

Sodium Borohydride 7 14 14 Hazardou

s

Non-

Flamm

able 8

HDPE

carbouy(ByRoad)

Sodium Hydroxide 53 106 106 Hazardou

s

Non-

Flamm

able 55

HDPE

carbouy(ByRoad)

BPH/DHT

(Benign prostatic

hyperplasia

(BPH)

FINASTERIDE

16-DPA 16.7 10 33.4 Hazardou

s

Non-

Flamm

able 17

HDPE

carbouy(ByRoad)

3 Acetone 33.4 1000 66.7 Hazardou

s

Flamm

able 35

HDPE

carbouy(ByRoad)

Ammonia Solution (10%) 12.5 24 25 Hazardou

s

Non-

Flamm

able 13

HDPE

carbouy(ByRoad)

DDQ 7.33 172 14.7 Hazardou

s Non-

Flamm 8

HDPE

carbouy(ByRoad)


76

able

Hydrogen 0.333 1000 0.67 Hazardou

s

Flamm

able 0.4

Cyclinder NA

carbouy(ByRoad)

Hydrogen Peroxide (50%) 3.33 1600 6.7 Hazardou

s

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

Hyflo 1.766 280 3.6 Hazardou

s

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Isopropyl Alcohol 83.33 20 166.7 Hazardou

s

Flamm

able 90

HDPE

carbouy(ByRoad)

Methanol 166.7 1600 340 Hazardou

s

Flamm

able 200

HDPE

carbouy(ByRoad)

Palladium Carbon 2.67 770 5.5 Hazardou

s

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)

ɋ-Toluenesulfonic acid 0.333 100 0.7 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

sulfuric Acid 0.33 10 0.7 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)


77

tert-Butylamine 2.4 14 5 Hazardou

s

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)

Toluene 150 106 300 Hazardou

s

Flamm

able 155

HDPE

carbouy(ByRoad)

Antipsychotic FLUPHENZINE

DECONATE

NaoH Solution

0.7

1.2 1.2 Hazardou

s

Non-

Flamm

able 0.8

HDPE

carbouy(ByRoad)

Anhydrous Sodium Sulphate

0.02

0.04 0.04 Hazardou

s

Non-

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Decanoic acid

0.8

0.16 0.16 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

Chloroform

0.25

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Thionyl Chloride

0.35

0.7 0.7 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)


78

Sodium Bicarbonate

0.55

0.98 0.98 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Acetone 11

22 22 Hazardou

s

Flamm

able 12

HDPE

carbouy(ByRoad)

Oxalic Acid

0.85

1.6 1.6 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

Petroleum Ether 0.25

0.5 0.5 Hazardou

s

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Activated Carbon/hyflo

0.05

0.1 0.1 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

1 Analgesics Flurbiprofen 2,4-Difluoronitrobenzene

0.6

1.2 1.2 Hazardou

s

Non-

Flamm

able 0.7

HDPE

carbouy(ByRoad)

Acetic acid

0.355 0.62

5 0.625

Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Copper Powder

0.17

0.25 0.25 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)


79

Diethyl Methylmalonate

0.114 0.22

3 0.223

Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Dimethylformamide

0.32

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Hydrogen 0.5

1 1 Hazardou

s

Flamm

able 0.6

Cylinder

carbouy(ByRoad)

Isopropyl Nitrite 0.29

0.56 0.56 Hazardou

s

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Methanol 104

201 201 Hazardou

s

Flamm

able 105

HDPE

carbouy(ByRoad)

Palladium Carbon

0.02 0.04

5 0.045

Hazardou

s

Non-

Flamm

able 0.0

4

HDPE

carbouy(ByRoad)

Sodium Hydroxide

92

150 150 Hazardou

s

Non-

Flamm

able 95

HDPE

carbouy(ByRoad)

Toluene 194

256 256 Hazardou

s

Flamm

able 200

HDPE

carbouy(ByRoad)

Trichloroacetic acid 0.92

1.89 1.89 Hazardou

s Non-

Flamm

0.9

5

HDPE

carbouy(ByRoad)


80

able

2 Anti

hypoglycemia Glucose

3 Intramuscular

injection GLYCOFUROL

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

4 Antiemetic GRANISETRON HCL 1-Methyl-3-indazolecarboxylic

acid

0.504

9 1.1 1.1 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Endo-9-methyl-9-

azabicyclo[3.3.1]nonan-3-

amine

0.47

0.85 0.85 Hazardou

s

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Thionyl Chloride

0.846

6 1.5 1.5 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

Toluene 17

34 34 Hazardou

s

Flamm

able 18

HDPE

carbouy(ByRoad)


81

Isopropyl Alcohol (IPA) 35

70 70 Hazardou

s

Flamm

able 36

HDPE

carbouy(ByRoad)

Sodium sulphate

0.05

0.1 0.1 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

Hexane 2.7

5.2 5.2 Hazardou

s

Flamm

able 3

HDPE

carbouy(ByRoad)

Sodium Bicarbonate

2.19

4.19 4.19 Hazardou

s

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)

Triethylamine

0.34

0.64 0.64 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Methylene chloride

0.71

1.4 1.4 Hazardou

s

Non-

Flamm

able 0.8

HDPE

carbouy(ByRoad)

5 Antipsychotic HALOPERIDOL

DECANOATE CFB

0.8

1.6 1.6

Hazardou

s

Non-

Flamma

ble 0.9

HDPE

carbouy(ByRoad)

Methanol 0.89

1.6 1.6

Hazardou

s

Flamm

able 0.9

HDPE

carbouy(ByRoad)


82

Trimethylorth Formate

1.66

2.6 2.6

Hazardou

s

Non-

Flamm

able 1.7

HDPE

carbouy(ByRoad)

sulphuric acid cp 98%

0.01

0.02 0.02

Hazardou

s

Non-

Flamm

able 0.0

2

HDPE

carbouy(ByRoad)

Triethylamine

0.04

0.08 0.08

Hazardou

s

Non-

Flamm

able 0.0

8

HDPE

carbouy(ByRoad)

cpp

0.35

0.75 0.75 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Sodium carbonate anhydrous

0.31

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Toluene 9

18 18 Hazardou

s

Flamm

able 10

HDPE

carbouy(ByRoad)

Hydrochloric Acid commercial

0.5

1 1 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Caustic soda lye

7.5

14 14 Hazardou

s

Non-

Flamm

able 8

HDPE

carbouy(ByRoad)


83

Water

25.09

50 50

Non

Hazardou

s

Non-

Flamm

able 26

Tank NA

carbouy(ByRoad)

Liquor Ammonia

7.2

14.5 14.5 Hazardou

s

Non-

Flamm

able 7.5

HDPE

carbouy(ByRoad)

Ethyl Acetate 17.81

25.3 25.3 Hazardou

s

Flamm

able 18

HDPE

carbouy(ByRoad)

Sodium sulphate anhydrous

0.25

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.2

6

HDPE

carbouy(ByRoad)

Decanoic acid

1.06

2.03 2.03 Hazardou

s

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

Hexane 12.15

25 25 Hazardou

s

Flamm

able 13

HDPE

carbouy(ByRoad)

Thionyl Chloride

0.86

1.6 1.6 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

Acetone 0.5

1 1 Hazardou

s

Flamm

able 0.6

HDPE

carbouy(ByRoad)


84

Antihypotensive hydralazine hcl

Phthalazinone

1.72

2.6 Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Phosphorous Oxychloride

1.15

2.5 Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Dichloromethane

2

4 Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Hydrazine Hydrate

1.72

2.3 Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Isopropanol 25

4 Hazardou

s

Flamm

able

HDPE

carbouy(ByRoad)

Methanol 52

98 Hazardou

s

Flamm

able

HDPE

carbouy(ByRoad)

Hydrochloric Acid (HCL)

1.89

2.69 Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Norit charcoal DX-Ultra 0.248 0.45

3

Hazardou

s Non-

Flamm

HDPE

carbouy(ByRoad)


85

able

Hyflow

0.248 0.45

3

Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Aqueous ammonia

2.24

4.48 Hazardou

s

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Water

65

95

Non

Hazardou

s

Non-

Flamm

able

Tank NA

carbouy(ByRoad)

1

Anti-

hemorrhoids/anti

infection

HYDROCORTISONE

ACETATE

Hydrocortisone 0.952

1.82 1.82 Hazardou

s

Non-

Flamm

able 0.9

6

HDPE

carbouy(ByRoad)

Pyridine 2.857

5.2 5.2 Hazardou

s

Flamm

able 3

HDPE

carbouy(ByRoad)

Acetic acid 2.85 4.58

5 4.585

Hazardou

s

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)


86

Acetic Anhydride 0.952

1.81 1.81 Hazardou

s

Non-

Flamm

able 10

HDPE

carbouy(ByRoad)

DM Water 57.14

2 98 98

Non

Hazardou

s

Non-

Flamm

able 58

Tank NA

carbouy(ByRoad)


9.5 9.5 Hazardou

s

Non-

Flamm

able 6

HDPE

carbouy(ByRoad)

Charcoal 0.095

0.18 0.18 Hazardou

s

Non-

Flamm

able 0.1

HDPE

carbouy(ByRoad)

Hyflow 0.048 0.09

8 0.098

Hazardou

s

Non-

Flamm

able 0.1

2

HDPE

carbouy(ByRoad)

Anti-osteoporosis Ibandronate sodium

3-(N-Methyl-N-pentylamino)

propionic acid hyrdrochloride

0.76

0.98 0.98 Hazardou

s

Non-

Flamma

ble 0.8

HDPE

carbouy(ByRoad)

Phosphorous Trichloride 1.25

2.25 2.25 Hazardou

s

Non-

Flamma

ble 1.5

HDPE

carbouy(ByRoad)


87

Phosphorous acid 0.6

0.94 0.94 Hazardou

s

Non-

Flamma

ble 0.7

HDPE

carbouy(ByRoad)

Methane sulphonic acid 1.12

2.21 2.21 Hazardou

s

Non-

Flamma

ble 1.5

HDPE

carbouy(ByRoad)

Toluene 45

90 90 Hazardou

s

Flamma

ble 46

HDPE

carbouy(ByRoad)

Sodium hydroxide 1.14

2.24 2.24 Hazardou

s

Non-

Flamma

ble 1.5

HDPE

carbouy(ByRoad)

Methanol 23

46 46 Hazardou

s

Flamma

ble 24

HDPE

carbouy(ByRoad)

DM Water 16.01 32.1

2 32.12

NonHaza

rdous

Non-

Flamma

ble 17

Tank NA

carbouy(ByRoad)

Ibandrosate Sodium 1.1

2.2 2.2 Hazardou

s

Non-

Flamma

ble 1.3

HDPE

carbouy(ByRoad)

Acetone 33

66 66 Hazardou

s

Flamma

ble 35

HDPE

carbouy(ByRoad)

2


88

Anti-

inflammatery Ibuprofen

2-butyl-1,3-

diazaspiro[4,4]non-1-ene-4-

one hydrochloride

38..5

78 78 Hazardou

s

Non-

Flamma

ble 40

HDPE

carbouy(ByRoad)

5-[4'-(bromomethyl)biphenyl-

2-yl]-trityl-1H-tetrazole

26.8

52 52 Hazardou

s

Non-

Flamma

ble 27

HDPE

carbouy(ByRoad)

Methanolic HCL

103.3 206.

3 206.3

Hazardou

s

Non-

Flamma

ble 105

HDPE

carbouy(ByRoad)

Ethylacetate

150

300 300 Hazardou

s

Non-

Flamma

ble 155

HDPE

carbouy(ByRoad)

Methanol 200

400 400 Hazardou

s

Flamma

ble 250

HDPE

carbouy(ByRoad)

Toluene 150

300 300 Hazardou

s

Flamma

ble 155

HDPE

carbouy(ByRoad)

Methylene dichloride (MDC)

170

340 340 Hazardou

s

Non-

Flamma

ble 175

HDPE

carbouy(ByRoad)

Isopropanol(IPA) 180

360 360 Hazardou

s

Flamma

ble 185

HDPE

carbouy(ByRoad)

Acetone 150

300 300 Hazardou

s

Flamma

ble 155

HDPE

carbouy(ByRoad)

30% sodiumhydroxide lye 391 761 761 HazardouNon-

Flamma400

HDPE


89

s ble carbouy(ByRoad)

Water

175

345 345

Non

Hazardou

s

Non-

Flamma

ble 200

Tank NA

carbouy(ByRoad)

Sulfuric acid

7.5

14.5 14.5 Hazardou

s

Non-

Flamma

ble 8

HDPE

carbouy(ByRoad)

3 Activated Carbon

0.1

0.2 0.2 Hazardou

s

Non-

Flamma

ble 0.2

HDPE

carbouy(ByRoad)

Anti-

inflammatery INDOMETHACIN

N-(p-chlorobenzoyl)-N-(p-

methoxyphenyl)-hyrazine

0.8

1.6 1.6 Hazardou

s

Non-

Flamma

ble 0.9

HDPE

carbouy(ByRoad)

Hydrochloric Acid

0.2

0.4 0.4 Hazardou

s

Non-

Flamma

ble 0.3

HDPE

carbouy(ByRoad)

Methanol 3.27

6.31 6.31 Hazardou

s

Flamma

ble 4

HDPE

carbouy(ByRoad)

Ethyl Acetate 5.33

9.02 9.02 Hazardou

s

Flamma

ble 5.5

HDPE

carbouy(ByRoad)


90

Levulinic acid

1.18

2.15 2.15 Hazardou

s

Non-

Flamma

ble 1.5

HDPE

carbouy(ByRoad)

Cyclohexane 0.9

1.8 1.8 Hazardou

s

Flamma

ble 1

HDPE

carbouy(ByRoad)

Water

3.712

6.5 6.5

Non

Hazardou

s

Non-

Flamma

ble 4

Tank NA

carbouy(ByRoad)

4 Acetone 4.06

8.9 8.9 Hazardou

s

Flamma

ble 4.5

HDPE

carbouy(ByRoad)

5 Radiologic(X-

ray)Examination

iohexol/iopamidol/iodixan

ol

5-amino-2,4,6-Tri

iodoisophthaloyl di chloride

0.9

1.8 1.8 Hazardou

s

Non-

Flamma

ble 1

HDPE

carbouy(ByRoad)

2-Amino-1,3-propanediol 1.2

2.4 2.4 Hazardou

s

Non-

Flamma

ble 1.3

HDPE

carbouy(ByRoad)


0.7 0.7 Hazardou

s

Non-

Flamma

ble 0.4

HDPE

carbouy(ByRoad)

Isopropyl Alcohol 4

8 8 Hazardou

s

Flamma

ble 5

HDPE

carbouy(ByRoad)

Iopamidol


91

Dimethyl Acetamide 0.409

0.8 0.8 Hazardou

s

Non-

Flamma

ble 0.5

HDPE

carbouy(ByRoad)

ATIPA Dichloride 0.35

0.7 0.7 Hazardou

s

Non-

Flamma

ble 0.4

HDPE

carbouy(ByRoad)

Actoxy Propionyl Chloride 0.125

0.2 0.2 Hazardou

s

Non-

Flamma

ble 0.2

HDPE

carbouy(ByRoad)

Vacuum salt 0.235

0.4 0.4 Hazardou

s

Non-

Flamma

ble 0.4

HDPE

carbouy(ByRoad)

DMF(Dimethyl Fornamide) 7.48

14.3 14.3 Hazardou

s

Non-

Flamm

able 8

HDPE

carbouy(ByRoad)

Chloroform 0.782

0.94 0.94 Hazardou

s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)

IPA 61.13

98 98 Hazardou

s

Flamm

able 65

HDPE

carbouy(ByRoad)

Mathanol 23.77

46.8 46.8 Hazardou

s

Flamm

able 25

HDPE

carbouy(ByRoad)

TEA 0.126 0.24

5 0.245

Hazardou

s Non-

Flamm

0.1

5

HDPE

carbouy(ByRoad)


92

able

Serinol 0.98

1.8 1.8 Hazardou

s

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)

MC-VII 0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

Carbon 0.052

0.08 0.08 Hazardou

s

Non-

Flamm

able 0.0

6

HDPE

carbouy(ByRoad)

Liquor Ammonia 0.141

6 0.28

3 0.283

Hazardou

s

Non-

Flamm

able 0.1

5

HDPE

carbouy(ByRoad)

6

Antiallergies/antic

hronic obstructive

pulmonary

disease

ipratropium bromide

Tropine 0.25

0.5 0.5 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Tropic acid 0.25

0.5 0.5 Hazardou

s Non-

Flamm 0.3

HDPE

carbouy(ByRoad)


93

able

Hydrochloric Acid 0.58

1.25 1.25 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Water 42

86 86

Non

Hazardou

s

Non-

Flamm

able 45

Tank NA

carbouy(ByRoad)


1.5 1.5 Hazardou

s

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

Isopropyl bromide 17

34 34 Hazardou

s

Flamm

able 20

HDPE

carbouy(ByRoad)

Methylene dichloride 2.75

4.9 4.9 Hazardou

s

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)

Antihypotensive Irbesartan

2-butyl-1,3-

diazaspiro[4,4]non-1-ene-4-

one hydrochloride

0.34

0.65 0.65 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

5-[4'-(bromomethyl)biphenyl-

2-yl]-trityl-1H-tetrazole

0.839


s

Non-

Flamm

able 0.9

HDPE

carbouy(ByRoad)


94

Methanolic HCL 0.103 0.25

3 0.253

Hazardou

s

Non-

Flamm

able 0.2

01

HDPE

carbouy(ByRoad)

Ethylacetate 0.15

0.3 0.3 Hazardou

s

Non-

Flamm

able 0.3

HDPE

carbouy(ByRoad)

Methanol 200

400 400 Hazardou

s

Flamm

able 201

HDPE

carbouy(ByRoad)

Toluene 150

300 300 Hazardou

s

Flamm

able 151

HDPE

carbouy(ByRoad)

Methylene dichloride (MDC) 170

340 340 Hazardou

s

Non-

Flamm

able 171

HDPE

carbouy(ByRoad)

Isopropanol(IPA) 180

360 360 Hazardou

s

Flamm

able 181

HDPE

carbouy(ByRoad)

Acetone 150

300 300 Hazardou

s

Flamm

able 151

HDPE

carbouy(ByRoad)

30% sodiumhydroxide lye 0.391

0.69 0.69 Hazardou

s

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Water 175 350 350

Non

Hazardou

s

Non-

Flamm 176

Tank NA

carbouy(ByRoad)


95

able

Sulfuric acid 0.75

150 150 Hazardou

s

Non-

Flamm

able 0.7

6

HDPE

carbouy(ByRoad)

Activated Carbon 0.1

0.2 0.2 Hazardou

s

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Anti-

bradycardia/anti

asthma

ISOPRENALINE

Isoprenaline base 0.3

0.6 0.6 Hazardou

s

Non-

Flamm

able 0.7

HDPE

carbouy(ByRoad)

7 Isopropyl Alcohol (IPA) 14

28 28 Hazardou

s

Flamm

able 30

HDPE

carbouy(ByRoad)

8 Anti-

inflammatery Ketorolac Tromethamine

Acetone 395.8

3

791.

66 791.66

Hazardou

s

Flamm

able 400

HDPE

carbouy(ByRoad)

Aluminum Chloride 41.66

6

83.3

2 83.32

Hazardou

s Non-

Flamm 45

HDPE

carbouy(ByRoad)


96

able

9

Bezoyl Chloride

45 90 90 Hazardou

s

Non-

Flamm

able 46

HDPE

carbouy(ByRoad)

Cyclohexane 354.1

666

708.

33 708.33

Hazardou

s

Flamm

able 355

HDPE

carbouy(ByRoad)

Dibenzoyl Peroxide

0.416 0.83

2 0.832

Hazardou

s

Non-

Flamm

able 0.4

5

HDPE

carbouy(ByRoad)

Methanol 145.8

33

291.

666

291.66

6

Hazardou

s

Flamm

able 146

HDPE

carbouy(ByRoad)

Methyl -y-Methoxy butanoate

31.25 62.5 62.5 Hazardou

s

Non-

Flamm

able 32

HDPE

carbouy(ByRoad)

Perchloric Acid 27.08

33

54.1

66 54.166

Hazardou

s

Non-

Flamm

able 28

HDPE

carbouy(ByRoad)

Pyrrol 20.83

3

41.6

66 41.666

Hazardou

s

Non-

Flamm

able 21

HDPE

carbouy(ByRoad)

Sodium Hydroxide

82.08 164.

16 164.16

Hazardou

s Non-

Flamm 83

HDPE

carbouy(ByRoad)


97

able

Sulfuric Acid 12.91

6

25.8

32 25.832

Hazardou

s

Non-

Flamm

able 13

HDPE

carbouy(ByRoad)

10

Tromethamine

25 50 50 Hazardou

s

Non-

Flamm

able 26

HDPE

carbouy(ByRoad)

Antiarrhythmic Lidocaine base or lidocaine

2,6-Xylidine 111.3

8 223 223 Hazardou

s

Non-

Flamm

able 112

HDPE

carbouy(ByRoad)

Chloroacetyl chloride 119.1

3 225 225 Hazardou

s

Non-

Flamm

able 120

HDPE

carbouy(ByRoad)

Sodium carbonate 111.3

8 225 225 Hazardou

s

Non-

Flamm

able 115

HDPE

carbouy(ByRoad)

Toluene 379.5

600 600 Hazardou

s

Flamm

able 400

HDPE

carbouy(ByRoad)

Diethylamine 77.64

112 112 Hazardou

s

Flamm

able 80

HDPE

carbouy(ByRoad)

Sodium carbonate 92.66 180 180 HazardouNon-

Flamm100

HDPE


98


Hydrochloric acid

80.71

160 160 Hazardou

s

Non-

Flamm

able 90

HDPE

carbouy(ByRoad)

Hyflo super cell

8.07

16 16 Hazardou

s

Non-

Flamm

able 9

HDPE

carbouy(ByRoad)

Aq.Ammonia solution

96.85

150 150 Hazardou

s

Non-

Flamm

able 100

HDPE

carbouy(ByRoad)

11 Activated carbon

8.07

16 16 Hazardou

s

Non-

Flamm

able 9

HDPE

carbouy(ByRoad)

12 Anti-Maleria Lumefantrine

2D-N-Butyl-I(2,7 Dichloro)

9H Fluoreny Ethanol

250

500 500 Hazardou

s

Non-

Flamm

able 255

HDPE

carbouy(ByRoad)

Caustic soda Flakes

50

100 100 Hazardou

s

Non-

Flamm

able 55

HDPE

carbouy(ByRoad)

Para Chloro Benzeldehyde

100

200 200 Hazardou

s

Non-

Flamm

able 105

HDPE

carbouy(ByRoad)


99

n-Hexane 100

200 200 Hazardou

s

Flamm

able 105

HDPE

carbouy(ByRoad)

Acetone 250

500 500 Hazardou

s

Flamm

able 255

HDPE

carbouy(ByRoad)

Methanol 200

400 400 Hazardo

us

Flamm

able 205

HDPE

carbouy(ByRoad)

Anti-

inflammatery LYSINE SALICYLATE

DL--Lysine

0.9

1.8 1.8 Hazardo

us

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)

Glycine

0.45

0.9 0.9 Hazardo

us

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Water

36

72 72 NonHaz

ardous

Non-

Flamm

able 40

Tanks NA

carbouy(ByRoad)

Aspirin

0.117

1.22 1.22 Hazardo

us

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

Activated Charcoal

0.075

0.17 0.17 Hazardo

us

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)


100

13 Isopropyl Alcohol (IPA) 95

115 115 Hazardo

us

Flamm

able 100

HDPE

carbouy(ByRoad)

14 Anti-Diabetic Metformin hydrochloride

Dimethylamine HCL 293 586 586 Hazardo

us

Non-

Flamm

able 300

HDPE

carbouy(ByRoad)

Dicyandiamide 305.7 611.

4 611.4

Hazardo

us

Non-

Flamm

able 306

HDPE

carbouy(ByRoad)

Dimethyl Formamide (DMF) 120 240 240 Hazardo

us

Non-

Flamm

able 125

HDPE

carbouy(ByRoad)

Toluene 194 388 388 Hazardo

us

Flamm

able 200

HDPE

carbouy(ByRoad)

Methanol 40 80 80 Hazardo

us

Flamm

able 45

HDPE

carbouy(ByRoad)

Carbon 4.8 9.6 9.6 Hazardo

us

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

15 Methocarbamol


101

Guifenesin

3.51

6.5 6.5 Hazardo

us

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

Dimethyl Carbonate

1.59

3.2 3.2 Hazardo

us

Non-

Flamm

able 1.6

HDPE

carbouy(ByRoad)

Ammonium Chloride

0.04

0.08 0.08 Hazardo

us

Non-

Flamm

able 0.0

5

HDPE

carbouy(ByRoad)

Toluene 185

250 250 Hazardo

us

Flamm

able 190

HDPE

carbouy(ByRoad)

Water

72

150 150

Non

Hazardo

us

Non-

Flamm

able 75

Tank NA

carbouy(ByRoad)

Methanol 200

400 400 Hazardo

us

Flamm

able 220

HDPE

carbouy(ByRoad)

Anti-hypertensive METOPROLOL

SUCICNATE Epichlorohydrine

0.54

0.98 0.98 Hazardo

us

Non-

Flamm

able 0.6

HDPE

carbouy(ByRoad)

4-Methoxy ethyl phenol 0.69 0.95 0.95 HazardoNon-

Flamm0.7

HDPE


102

us able carbouy(ByRoad)

TBAB

0.01

0.02 0.02 Hazardo

us

Non-

Flamm

able 0.0

2

HDPE

carbouy(ByRoad)

Sodium hydroxide lye

0.47

0.98 0.98 Hazardo

us

Non-

Flamm

able 0.5

HDPE

carbouy(ByRoad)

Isopropyl alcohol (IPA) 0.87

1.64 1.64 Hazardo

us

Flamm

able 0.9

HDPE

carbouy(ByRoad)

Anti-hypertensive METOPROLOL

TARTRATE Isopropyl Alcohol (IPA)

1.7 3.4 3.4

Hazardo

us

Flamm

able 2

HDPE

carbouy(ByRoad)

Hyflow

0.005

8 0.01

16 0.0116

Hazardo

us

Non-

Flamm

able 0.0

066

HDPE

carbouy(ByRoad)

Metoprolo

1.159

4 2.34

5 2.345

Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Activated Carbon +IPA

0.136

2 0.26

35 0.2635

Hazardo

us

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Isopropyl Alcohol (Wash) 0.4

0.8 0.8 Hazardo

us

Flamm

able 0.5

HDPE

carbouy(ByRoad)


103

Anti-fungal NATAMYCIN

Hazardo

us

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Anticholinesterase

NEOSTIGMINE

METHYL SULPHATE

/BROMIDE

3-(Dimethylamino)phenol 0.198 1.5 1.5 Hazardo

us

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)

Acetone 22 44 44 Hazardo

us

Flamm

able 25

HDPE

carbouy(ByRoad)

Dimethyl Sulfate 0.15 0.3 0.3 Hazardo

us

Non-

Flamm

able 0.1

8

HDPE

carbouy(ByRoad)

Dimethyl Carbamoyl Chloride 5.133 10.3

66 10.366

Hazardo

us

Non-

Flamm

able 6

HDPE

carbouy(ByRoad)

Potassium Hydroxide 0.34 0.64 0.64 Hazardo

us

Non-

Flamm

able 0.4

HDPE

carbouy(ByRoad)

Toluene 44.66 88.7 88.7 Hazardo Flamm 45 HDPE


104


Antihypotensive NORADRENALINE

BITARTRATE

Hazardo

us

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Anti-cancer PAMIDRONIC ACID

Hazardo

us

Non-

Flamm

able

HDPE

carbouy(ByRoad)

Antiepileptic

PANCURONIUM

BROMIDE

Hazardo

us

Non-

Flamm

able

HDPE

carbouy(ByRoad)

HDPE

carbouy(ByRoad)

HDPE

carbouy(ByRoad)

Anti-Cancer PHOSPHATIDYLCHOLI

NE HYDROGENATED

Hazardo

us

Non-

Flamm

able

HDPE

carbouy(ByRoad)

HDPE

carbouy(ByRoad)

Anticonvulsant PHYTOMENANDIONE

Hazardo

us

Non-

Flamm

able

HDPE

carbouy(ByRoad)


105

Acetic Anhydride 28 56 56 Hazardo

us

Non-

Flamm

able 30

HDPE

carbouy(ByRoad)

Cyclohexane 1110 2220 2220 Hazardo

us

Flamm

able 112

0

HDPE

carbouy(ByRoad)

Hydrogen 1 2 2 Hazardo

us

Flamm

able 1.2

Cylinder

carbouy(ByRoad)

Menadione 13 26 26 Hazardo

us

Non-

Flamm

able 15

HDPE

carbouy(ByRoad)

Methanol 120 240 240 Hazardo

us

Flamm

able 125

HDPE

carbouy(ByRoad)

Methylene Dichloride 230 460 460 Hazardo

us

Non-

Flamm

able 250

HDPE

carbouy(ByRoad)

Phytol 20 40 40 Hazardo

us

Non-

Flamm

able 25

HDPE

carbouy(ByRoad)

Potassium Carbonate 11 22 22 Hazardo

us

Non-

Flamm

able 12

HDPE

carbouy(ByRoad)

Potassium Hydroxide 9 18 18 Hazardo

us Non-

Flamm 10

HDPE

carbouy(ByRoad)


106

able

Silica Gel 92 184 184 Hazardo

us

Non-

Flamm

able 95

HDPE

carbouy(ByRoad)

1 Anti-

inflammatery

PREDNISOLONE

ACETATE

Pyridine

123

246 246 Hazardo

us

Non-

Flamm

able 125

HDPE

carbouy(ByRoad)

Pridinisilo

25

50 50 Hazardo

us

Non-

Flamm

able 30

HDPE

carbouy(ByRoad)

Acetic Anhydride

25

50 50 Hazardo

us

Non-

Flamm

able 30

HDPE

carbouy(ByRoad)

Hydrochloric Acid

12

24 24 Hazardo

us

Non-

Flamm

able 15

HDPE

carbouy(ByRoad)

Carbon

2

4 4 Hazardo

us

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

DMF(Dimethyl Fornamide) 19 40 40 HazardoNon-

Flamm20

HDPE


107


Water

375

450 450 NonHaz

ardous

Non-

Flamm

able 400

Tank NA

carbouy(ByRoad)

Methanol 10

20 20 Hazardo

us

Flamm

able 11

HDPE

carbouy(ByRoad)

2

Anti-

epileptic/Anticonv

ulsant

pregabalin

HDPE

carbouy(ByRoad)

Acetic acid 73.85

150 150 Hazardo

us

Non-

Flamm

able 75

HDPE

carbouy(ByRoad)

Diethyl -(1-Cyano-3-

methylbutyl)Propanedioate

225.5

5 500 500 Hazardo

us

Non-

Flamm

able 250

HDPE

carbouy(ByRoad)

Hydrochloric Acid(35%) 31.94

62 62 Hazardo

us

Non-

Flamm

able 32

HDPE

carbouy(ByRoad)

Hydrogen 3.94

7 7 Hazardo

us

Flamm

able 4

Tank NA

carbouy(ByRoad)


150 150 Hazardo

us Flamm 75

HDPE

carbouy(ByRoad)


108

able

Methanol 129.4

1 250 250

Hazardo

us

Flamm

able 130

HDPE

carbouy(ByRoad)

Potassium Hydroxide 49.9

80 80 Hazardo

us

Non-

Flamm

able 50

HDPE

carbouy(ByRoad)

Raney-Nickel 0.142 0.24

5 0.245

Hazardo

us

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)

S(+)Mandelic acid 0.129

4 0.24

5 0.245

Hazardo

us

Non-

Flamm

able 0.2

5

HDPE

carbouy(ByRoad)


50.9 50.9 Hazardo

us

Non-

Flamm

able 50

HDPE

carbouy(ByRoad)

3 Antipsychotic Quetiapine fumerate

Toluene 121

212 212 Hazardo

us

Flamm

able 122

HDPE

carbouy(ByRoad)

IPA 88

160 160 Hazardo

us

Flamm

able 90

HDPE

carbouy(ByRoad)

Dibenzo[b,f][1,4]thiazepine 11

(10H)-one

15 30 30 Hazardo

Non-

Flamm20

HDPE


109


1-[2-(2-Hydroxy Ethoxy)

Ethyl]Piperzine

12

24 24 Hazardo

us

Non-

Flamm

able 15

HDPE

carbouy(ByRoad)

Fumaric acid 36

75 75 Hazardo

us

Non-

Flamm

able 40

HDPE

carbouy(ByRoad)

N,N-Dimethyl Aniline 4.8

8.5 8.5 Hazardo

us

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

sodium sulphate 1.5

3 3 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

POCl3 1.1

2.2 2.2 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)


0.9 0.9 Hazardo

us

Non-

Flamm

able 7

HDPE

carbouy(ByRoad)

Water 137

267 267

Non

Hazardo

us

Non-

Flamm

able 140

Tank NA

carbouy(ByRoad)

Methanol 232 500 500 Hazardo Flamm 230 HDPE


110


Potassium Carbonate 1.01

2.02 2.02 Hazardo

us

Non-

Flamm

able 1.5

HDPE

carbouy(ByRoad)

Vacuum salt 2.2

4.4 4.4 Hazardo

us

Non-

Flamm

able 2.3

HDPE

carbouy(ByRoad)

4 Antibiotics Rabeprazole sodium

2,3-Lutidine 46.1

96 96 Hazardo

us

Non-

Flamm

able 50

HDPE

carbouy(ByRoad)

Hydrogen peroxide (50%) 29.3

50 50 Hazardo

us

Non-

Flamm

able 30

HDPE

carbouy(ByRoad)

Nitric acid 27.1

51 51 Hazardo

us

Non-

Flamm

able 30

HDPE

carbouy(ByRoad)

Acetic Acid 60

90 90 Hazardo

us

Non-

Flamm

able 65

HDPE

carbouy(ByRoad)

Sulfuric acid 80 90 90 HazardoNon-

Flamm85

HDPE


111


3-Methoxy-1-Propanol 34.8

70 70 Hazardo

us

Flamm

able 35

HDPE

carbouy(ByRoad)


30 30 Hazardo

us

Non-

Flamm

able 16

HDPE

carbouy(ByRoad)

Toluene 140

180 180 Hazardo

us

Flamm

able 150

0

HDPE

carbouy(ByRoad)

Dimehyl suloxide 195

250 250 Hazardo

us

Non-

Flamm

able 200

HDPE

carbouy(ByRoad)

Acetic Anhydride 86.3

90 90 Hazardo

us

Non-

Flamm

able 90

HDPE

carbouy(ByRoad)


20 20 Hazardo

us

Non-

Flamm

able 15

HDPE

carbouy(ByRoad)

Hydrochloric Acid 13

21 21 Hazardo

us

Non-

Flamm

able 15

HDPE

carbouy(ByRoad)

Thionyl Chloride 34.8

40 40 Hazardo

us Non-

Flamm 35

HDPE

carbouy(ByRoad)


112

able

2-Mercapto benzimidazole 48.5

55 55 Hazardo

us

Non-

Flamm

able 50

HDPE

carbouy(ByRoad)


40 40 Hazardo

us

Non-

Flamm

able 40

HDPE

carbouy(ByRoad)

Sodium Hypochlorite(4%) 54

65 65 Hazardo

us

Non-

Flamm

able 550

HDPE

carbouy(ByRoad)

Methylene Dichloride 40

58 58 Hazardo

us

Non-

Flamm

able 450

HDPE

carbouy(ByRoad)

Carbon 0.1

0.2 0.2 Hazardo

us

Non-

Flamm

able 20

HDPE

carbouy(ByRoad)

n-Hexane 25

50 50 Hazardo

us

Flamm

able 300

HDPE

carbouy(By Road)

Isopropyl Alcohol 25

50 50 Hazardo

us

Flamm

able 300

HDPE

carbouy(By Road)

Water 231

356 356

Non

Hazardo

us

Non-

Flamm231

5

Tank NA

carbouy(By Road)


113

able

5 Anti-Pagetis

disease Residronate Na

Methanol 18

36 36 Hazardo

us

Flamm

able 20

HDPE

carbouy(By Road)

Methylene chloride 28

60 60 Hazardo

us

Non-

Flamm

able 30

HDPE

carbouy(By Road)

Nicotinic acid 2

4 4 Hazardo

us

Non-

Flamm

able 3

HDPE

carbouy(ByRoad)

Sulfuric acid 4

8 8 Hazardo

us

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

Sodium chloride 1

2 2 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Ice 17

35 35 Hazardo

us

Non-

Flamm

able 20

HDPE

carbouy(ByRoad)

Liquor Ammonia(25%) 8

16 16 Hazardo

us

Non-

Flamm

able 9

HDPE

carbouy(ByRoad)


114

Ethyl Acetate 4

8 8 Hazardo

us

Flamm

able 5

HDPE

carbouy(ByRoad)

SMO powder 1

2 2 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Potassium Carbonate 1

2 2 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

HCL 4

8 8 Hazardo

us

Non-

Flamm

able 5

HDPE

carbouy(ByRoad)

Morpholine 1

2 2 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Sulfur powder 1

2 2 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Acetone 13

26 26 Hazardo

us

Flamm

able 15

HDPE

carbouy(ByRoad)

IPA HCL 6

12 12 Hazardo

us

Flamm

able 7

HDPE

carbouy(ByRoad)

C.S Flakes 4

8 8 Hazardo

us Non-

Flamm 5

HDPE

carbouy(ByRoad)


115

able


0.04 0.04 Hazardo

us

Non-

Flamm

able 0.0

4

HDPE

carbouy(ByRoad)

Toluene 1

2 2 Hazardo

us

Flamm

able 2

HDPE

carbouy(ByRoad)

Methane sulfonyl Chloride 2

4 4 Hazardo

us

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

6

Phosphorous acid 1

2 2 Hazardo

us

Non-

Flamm

able 2

HDPE

carbouy(ByRoad)

Fat soluble

molecules

SOYA LECITHIN

POWDER

7

Soya Lecithin powder 10.2

20.4 20.4 Hazardo

us

Non-

Flamm

able 11

HDPE

carbouy(ByRoad)

Acetone 0.025

0.05 0.05 Hazardo

us

Flamm

able 0.0

3

HDPE

carbouy(ByRoad)

Anti-varicella

Zoster/anti-virus VALACYCLOVIR

Acyclovir 0.66 1.2 1.2

Hazardo

us Non-

Flamm 0.7

HDPE

carbouy(ByRoad)


116

able

N-cbz-L-Valine 1.108

8 2.2 2.2 Hazardo

us

Non-

Flamm

able 1.2

HDPE

carbouy(ByRoad)

DD(N,N'-

dicyclohexylcarbodiimide)

0.963

6 1.8 1.8 Hazardo

us

Non-

Flamm

able 1

HDPE

carbouy(ByRoad)

DMF(Dimethyl Fornamide) 3.115

2 6.13 6.13 Hazardo

us

Non-

Flamm

able 4

HDPE

carbouy(ByRoad)

DMPA(4-

Dimethyaminopyridine)

0.017

82 0.03

5 0.035

Hazardo

us

Non-

Flamm

able 0.0

2

HDPE

carbouy(ByRoad)

Methanol 2.8

5.2 5.2 Hazardo

us

Flamm

able 3

HDPE

carbouy(ByRoad)

5% Palladium on

carbon(50%wet)

0.15

0.3 0.3 Hazardo

us

Non-

Flamm

able 0.2

HDPE

carbouy(ByRoad)


117

Annexure II: Detailed equipment list with capacity

NAME OF THE EQUIPMENT QTY CAPACITY

BLOCK -1

INTERMEDIATE PROCESSING

P1-1 Non GMP SS Reactor with HE,column &receiver 2KL 1

P1-2 Non GMP Glassline Reactor with HE, column &receiver 3KL 1

P1-3 GMP SS Centrifuge including MLT 48" 1

P1-4 Non GMP Tray dryer 96 Trays 1

P1-5 Sparkler filter 18" 1

P1-6 SS Receiver 1 KL 1

P1-7 SS Receiver 1 KL 1

GMP PROCESSING

P1-8 GMP glass lined Reactor with HE,column &receiver 3KL 1

P1-9 ANFD 2KL 1

P1-10 Tray dryer GMP 96 Trays 1

P1-11 FLP Weighing balance 100 Kg 1

P1-12 Non FLP Weighing balance 100 Kg 1

P1-13 Multimill 101 Kg/hr 1


118

P1-14 Sifter 30" 1

P1-15 Blender 1KL 1

BLOCK -2

INTERMEDIATE PROCESSING

P2-1 Non GMP SS Reactor with HE,column &receiver 2KL 1

P2-2 Non GMP Glassline Reactor with HE,column &receiver 3KL 1

P2-3 GMP SS Centrifuge including MLT 48" 1

P2-4 Non GMP Tray dryer 96 Trays 1

P2-5 Sparkler filter 18" 1

P2-6 SS Receiver 1KL 1

P2-7 SS Receiver 1KL 1

GMP PROCESSING

P2-7 GMP glass lined Reactor with HE,column &receiver 3KL 1

P2-8 ANFD 2KL 1

P2-9 Tray dryer GMP 96 Trays 1

P2-10 FLP Weighing balance 100kg 1

P2-11 Non FLP Weighing balance 100kg 1

P2-12 Multimill 100kg/hr 1

P2-13 Sifter 30" 1

P2-14 Blender 1KL 1

PLC CONTROLS FOR BATCH MFG

Automated process controls by PLC 1

UTILITY EQUIPMENTS


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U1 Cooling tower 1 400 TR

U2 Chilling plant 2 120TR

U3 Brine plant 1 30 TR

U4 Pumps 4 As per chiller /CT

U5 Tanks 2 2500 LIT

U6 Nitrogen plant 1 120CFM

U7 Steam Boiler 1 1500Kg/hr

U8 Chimney 1 30 met High

U9 DM Water & RO system 1 3000 lit/hr

U10 Gas Scrubbers 1 200 CFM

U11 Solvent Recovery columns 2 As per design

U12 Zero discharge Effluent treatment plant 1 450000 LPD


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pre feasibility report for - welcome to...

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