ppt jurnal 3 das-mri

7/27/2019 Ppt Jurnal 3 DAS-MRI

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PresenterDr. M. Dasawarsa. R

Moderator

Dr. Ratih krisna, Sp.OG (K)


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Pre-eclampsia/eclampsia is one of the most

common causes of maternal and perinatal

morbidity and mortality in low and middleincome countries

Magnesium sulfate is the drug of choice for

prevention of seizures as part of

comprehensive management of the disease


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To determine whether the published literature

from low-and middle-income countries

supports the concern about the safety of use ofmagnesium sulfate


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An integrative review of the literature was

conducted to document the known incidences

of severe adverse reactions to magnesiumsulfate, and specific outcomes of interest

related to its use

MEDLINE (via PubMed), Embase, and the

Cochrane. Searches were limited to the years

1980 through February 2012


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Inclusion criteria

Magnesiumsulfate was usedto manage pre-eclampsia or

eclampsia in aprospectiveclinical study

The study wasconducted in a

low-or middle-income country

The studyincluded the

recording of theincidence of any

adverse sideeffect resulting

from magnesiumsulfate use


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Exclusion criteria

The study had beenconducted in high-incomecountries (where treatmentand monitoring approaches

may differ)

Did not specifically recordthe incidence of side

effects related tomagnesium sulfate use


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The findings demonstrate that across all theincluded studies the adverse effects that areoften of concern to providers occur infrequently,

and that when adverse effects occurred, delay ofrepeat administration was generally sufficient tomitigate the effect.

While every maternal death is regrettable,maternal mortality directly attributable to theuse of magnesium sulfate reported in thesestudies was extremely rare.


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1. Are the represented sample have

the same condition regarding their

disease?

Yes

2. Are sample followed up

completely and prolonged?

No, they not followed

up completely and

prolonged

3. Are result criteria got blinded? Not mention


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4. If subgroup found with different

prognosis, are they performed

adjustment on important prognostic

factors ?

Yes

5. How about result tendency on

certain duration ?

Yes

6. How accurate prognostic

prediction?

P < 0.05


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7. Could you applicate valid

important prognostic evidence from

your patient?Yes

8. Are patients on your study as

same as patient at your clinical

practice ?Yes

9. Are important clinical evidenceaffect your conclusion for advising or

explaining your patient ?

Yes


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