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Efficient processes. Innovative therapies. Streamlining workflows. Dialog with the future Hemodialysis

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Efficient processes. Innovative therapies.Streamlining workflows.

Dialog with the future

B. Braun Medizintechnologie GmbH

Schwarzenberger Weg 73-7934212 MelsungenGermanyTel +49(0) 56 61 71-3716Fax +49(0) 56 61 75-3716

www.bbraun-dialysis.comW. 02.10.08/2 No. 708 0075A Edition: 10/2008

Potential through individuality

Hemodialysis

The ABPM OptionThe automatic blood pressure measurement or ABPM option ensures dependable monitoring of your patients. Automatically,accurately and non-invasively, Dialog+ measures blood pressureusing the oscillometric method. This takes a burden off the staffand enhances safety for your patients.

The benefits of the ABPM option

n Easy BP measurement at all times – before, during and after dialysis

n Automatic readings at regular intervalsn BP and pulse rate are clearly displayed on the main screenn Alarm limits can be individually adapted to patient's blood

pressure by pressing a buttonn Selectable color display for blood pressure and pulse curvesn Real-time documentation of all readingsn Automatic cuff inflation adjustment

Dialysis fluid filter optionThe dialysis fluid filter option is used to significantly improve thequality and purity of the dialysis fluid delivered by the dialysismachine. In an additional filtration stage, the dialysis fluid ispumped through the Diacap® Ultra dialysis fluid filter to filterand absorb any microbial impurities from the dialysate.

Obviously, treatment with ultrapure dialysis fluid has clinicaladvantages. Chronic inflammatory processes triggered by pyrogen impurities (cytokine-induced formation of interleukin,TNF, �2-microglobulin amyloidosis etc.) are markedly reduced.This reduction is associated with a positive effect on the pati-ent's general, nutritional and cardiovascular status.

The dialysis fluid filter option lets you significantly improve thequality of the dialysis treatment. Consequently, you promotepatient's health and extend their life expectancy. At the sametime, you achieve a high savings potential by preventing againstlikely complications and the consequential costs associated withthem.

Option HDF OnlineWith the Dialog+ Online version, you can carry out high-volumehemodiafiltration with substitution solutions manufactured bythe dialysis machine online. The solution is made from the dialysis fluid that is put through an additional 2-stage filtrationcycle run through two sequentially connected Diacap® Ultra dialysis fluid filters.

Combining diffusive and convective clearance improves the elimination of small and medium-sized molecules. Likewise, HDFOnline is also suitable for patients with unstable cardiovascularstatus who tend to experience a strong drop in blood pressureeven at low ultrafiltration volumes.

It is important that all features and accessories fit …… I want to be able to leverage my options – now and in the future.

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Sharing Expertise

B. Braun – A visionary on the healthcare market

Dialog+ was developed from a synergy of expertise and heritage by one of the leading corporations on the healthcare market.Backed by a 166-year history of industrial innovations and power,the company's well-balanced portfolio is stocked with over30,000 products that are sold in 50 countries on all 5 continents.Over 32,000 employees work for the B. Braun group globally. It is they who have made a major contribution to its success: In 2006, corporate revenues exceeded three billion euros.

Corporate structure: Structured competency

The group is organized into four divisions. Each division's products and services address different areas of medicine andtherapy. B. Braun Avitum develops and manufactures systems forextracorporeal blood treatment and operates dialysis centers inEurope, Asia and Africa. Hospital Care is an innovative developerof product and service concepts for hospitals. Out Patient Market(OPM) provides solutions for private medical practices and thehomecare market. Aesculap specializes in surgical core processes.The expertise of these four divisions is bundled into a competentwhole. B. Braun, a global corporation that unites convincing performance with competent leadership. B. Braun. More than the sum of its parts.

Dialog+ – Evolutionizing hemodialysisDriven by our motto, “Sharing Expertise”, we have always maintained a worldwide dialog with our customers, partners andmedical researchers. That's why we named our latest and mostinnovative hemodialysis system Dialog+. Our mission is to developsolutions that not only sustainably improve, but also evolutionizehealthcare. Excellent communication and visionary thinking areneeded if we want to move forward in our evolutionary development.

Dialog+ – The original from B. Braun

Decades of dialysis innovations

For decades, B. Braun has been improving the life of dialysis pati-ents around the globe with its innovative products and dependable services. For example, back in 1982, B. Braun intro-duced the HD 105, the first hemodialysis machine that measuredultrafiltration both up- and downstream from the dialyzer. Thistechnology enabled an improvement in dialysis safety. Twelveyears later, the Dialog dialysis machine, the predecessor toDialog+, was the first to feature convenient touch screen operation.These are just two notable examples of how B. Braun's visionshave been shaping the future of extracorporeal blood treatment.

Dialog+ embodies integration

Today, with Dialog+, B. Braun is again raising the bar in the fieldof hemodialysis. In Dialog+, intelligent software is perfectly integrated into sophisticated high-grade, hardware-equipped original accessories. As with every one of our products, every purchase is backed by excellent service support and dependableglobal logistics. When you acquire the world's most advancedhemodialysis system, you are buying the embodiment of our corporate values: innovation, efficiency and sustainability. Invest in the future. Invest in Dialog+ – The original from B. Braun.

Nexadia®: This innovative datamanagement solution stream-lines workflows - sustainably. Allpatient- and treatment-relateddata, equipment settings andother relevant information arecompiled, consolidated and stored. For the ultimate in process efficiency.

Hemodialysis

Sophisticated communications

A dialog ...

... only makes sense if it leads to better understanding. WithDialog+, we at B. Braun have proven how much we understandthe process of dialysis, the constraints of the market, thedemands of our customers and needs of our patients.

The result is

■ Sustainability based on future-proof concepts

■ Efficient work through automation andnetworking

■ Maturity of experience and proven solutions

■ Quality assurance through smart technology

■ Innovation created together with ourcustomers

The synergies of integrated systems

Dialysis centers: B. BraunAvitum never loses sight of itscommitment to practical appli-cation and patient proximity –just one of the reasons why weoperate dialysis centers inEurope, Asia and Africa. AtB. Braun Avitum centers, dialysispatients receive the highestlevel of healthcare worldwide.

Catheters: Haemocat® Signo,the catheter for extracorporealblood treatment, offers usersthe option of EKG-guidedcatheter positioning. Thismeans simplicity with maximum safety.

Diacap® � Polysulfone:The new dialyzer generation ofpolysulfone fibers meets thespecific requirements of themost complex of regimensranging up to and includingefficient high-flux hemodiafil-tration.

The innovative solutions from B. Braun are synonymous withexcellent medical care and streamlined clinical routines. Ourcustomers acquire integrated systems designed with perfectlycoordinated components.

Needles: Needlestick preventi-on in dialysis is gaining evermore importance. With thedevelopment of new needles forextracorporeal blood treatment,we are doing justice to thisneed. The Diacan® S safetyneedle with an integrated safety clip provides effectiveprotection.

Our customers benefit from a full-range of services including technical support, process advice, business management, consulting,planning, development, installation and training courses – all backedby the vast expertise of one of world's largest medical productscompanies.

A/V systems: Bloodlinesystems made of biocompatible,proven and innovative plasticizer-free componentsare the lifeline between pati-ent and dialyzer.

Solutions: B. Braun was thefirst manufacturer in Germanyto develop bicarbonate-buffered hemofiltration solutions. That this benefitspatients by reducing cardiovascular complicationshas been proven in clinicalstudies.

Concentrates: B. Braun produces a wide range of liquidacidic and alkaline bicarbonate-buffered hemodialysis concentrates for personalizedtreatment regimens. The Sol-Cart B® cartridge containingsodium hydrogen carbonatepowder is just one practicalalternative for users.

Dialog_engl_aussen_copy.qxd 06.06.2007 8:01 Uhr Seite 2

Communication is the concept:

Hemodialysis

The concept of multidimensional communications has become a clinical reality: The Dialog+ hemodialysis system harnesses breakthrough technology for more effective therapy on every level.

The most communicative dimension of Dialog+ is its outstandingnetwork compatibility. Created to interface with Nexadia®advanced data management software, the centralized bidirectional network monitors treatment safely and reliablyfrom start to finish. Therapeutic regimens are logically integrated in administrative processes. Nexadia® ensures that quality assurance and reliable verification meet both current and futurerequirements.

Dialog+ – Interactive functionality

The design of the Dialog+ hemodialysis machine brings sophisti-cated medical technology into detailed balance. Its form followsergonomic function. All components on the front panel are arranged in a practical way to facilitate user interaction and allowthe operator to adapt readily to changing therapeutic procedures.

Ergonomic

Lightweight yet sturdy, agile yet on a solid footing, Dialog+ withits swivel wheels offers the practical mobility needed for every-day routine. The high-resolution, swivelable 15" TFT monitor isextremely user friendly, allowing the information to be easilyread from any position and in all lighting conditions.

Functional

The menu navigation is straightforward and takes the diversity ofdialysis routine into account. The clear touch screen facilitates fastand easy handling. Self-explanatory symbols and understandableuser guidance make operation easier for less experienced operators.

Practical

Thanks to the standard-equipped treatment status color indicator, operators can reassure themselves, even from a distance, that the dialysis routine is running smoothly.

Dialog+– Ergonomic, functional and practical technology for safe and efficient dialysis.

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– Optimizing workflows

Thinking about tomorrow …

… before tomorrow comes. The ongoing dialog with our customershas shown that keeping overhead costs low has never been moreimportant. Nowadays, everybody is seeking affordable solutionsthat do not jeopardize the quality of care. Because Dialog+

hemodialysis systems are so efficient to operate, they amortizethemselves very quickly. Intelligent upgrade options ensure thatyour purchase will be a secure and intelligent investment now and in the future.

Slash operating costs

Uniting economy and ecology, Dialog+ can be programmed toautomatically activate the stand-by mode. This setting cuts backon water, concentrate volume and electricity consumption. Theauto-priming function saves saline solution during online HDFhemodiafiltration. Diacap® Ultra dialysis fluid filters have anabove-average lifetime of up to 150 treatments or approx. 900hours. That translates into significantly lower overhead costs.

All Dialog+ machines have an integrated technical service andmaintenance mode (TSM) for simplified troubleshooting anddocumentation. That converts to lower service and maintenancecosts. The customized configurations possible with the TSMmode additionally allow you to sustainably optimize the processes at your center. All of these features add up to long-term cost savings.

1 D. Osterkorn, "Networking for success in dialysis centers: A prospective comparative analysis" Gesundheitsökonomie & Qualitätsmanagement; 11: 112-115

Nexadia® – Communicating with the future

Nexadia® is your direct link to all the options the future has tooffer. Studies have shown that significant improvements inworkflows 1 and more effective utilization of resources can beachieved with the Dialog+ hemodialysis system's upgradeablebidirectional interface to Nexadia® data management software.Its multidimensional communications concept also supportsoptimal quality management. The machine can be preset usingNexadia® and the chip card. This saves time, which the staff profits from daily.

B. Braun has designed Dialog+ and Nexadia® to meet the broadvariety of challenges arising during everyday dialysis routine. Themodular design incorporates many advanced functional optionsand an array of practical configurations. B. Braun also continuesto work on further evolving the Dialog+ concept to make eachnew feature and accessory even more economical and keep itahead of the times. Dialog+ is an investment in the future.

Automatic functions – Less is more

Effortless and trouble-free. That would be one way to describeday-to-day hemodialysis with Dialog+. The broad range of auto-matic functions substantially minimizes the time and labor thestaff needs for routine processes.

For example, Dialog+ runs procedures like start-up tests andweekly disinfection cycles automatically. Moreover, the hemo-dialysis system detects the patient's blood in the A/V line and, if required, automatically delivers the preset heparin bolus.

Dialog_engl_innen_copy.qxd 06.06.2007 7:56 Uhr Seite 2

Hemodialysis

Economy meets sustainability

Cost pressure is mounting, …

… to provide the best medical care at the most cost-efficientprice. This tenet is the benchmark that will keep dialysis centers economically viable in the future.

The benefits of an ongoing dialog

■ Automation accelerates workflows and cuts overheads

■ Minimized water, energy and concentrateconsumption lowers operating costs

■ Individually configurable to center-specificprocesses

■ Nexadia® data management software forprocess optimization

Dialog_engl_innen_copy.qxd 06.06.2007 7:56 Uhr Seite 3

– Your clinical assistant

Greater proximity to the patient ...

… is sometimes achieved by more technology. This may soundparadoxical, but where time is money, pre-programmed routinesand automation can leave caregivers free to devote more personal attention to their patients. Handling simplicity is alsoimportant when it comes to reacting as safely and quickly as clinical routine demands.

Card reader for faster settingsThe Dialog+ Therapy Card minimizes the manual entry of patientdata. Dialog+ quickly scans the personalized settings with the CardReader and automatically sets all treatment parameters. Centersthat choose to utilize the advanced Nexadia® data managementsystem with all its potential options can alternatively downloaddata with a Nexadia® chip card.

Programmable disinfection with automaticdocumentationFor disinfection, Dialog+ is equipped with two unique, mutuallysupportive functions. One, the weekly disinfection routine, can beused to program and store two disinfection cycles per day. Theother, a comprehensive disinfection history, ensures qualitymanagement without added outlay for documentation.

Technical updates made simple and effectiveUpgrading Dialog+ software is easy with a USB stick and memorycard. The USB stick can also be used for storing and analyzing equipment data and the trends of previous treatments. Trouble-shooting has also been simplified. With the integrated technicalservice and maintenance mode (TSM), the profiles on all variablesand settings of previous treatments can be graphically displayedand evaluated. Individualized combinations of settings can beselected to ensure optimized handling and servicing.

Error-minimizing technologyIntuitively understandable: The Dialog+ touch screen is structuredaround self-explanatory 3D icons. This is another positivedimension that gives users a greater sense of operating securitybecause they know they can react fast to all therapeutic events.The learning curve for new staff is short, making it easy for them to operate the machine confidently on their own.

The menu navigation on Dialog+ virtually eliminates errors altogether: After important data is entered, the user just has to

confirm with the enter key to avoid errors. In all operating phases, the online help functions supportthe operator with plain language prompts and

instructions. These features make it easy for the healthcare staffto react the instant an alarm sounds and undertake correctivemeasures, with confidence and no hesitation.

The use of the Event Timer helps to remind the operator, forexample, to administer a specific drug or deliver a bolus ofheparin. The Event Timer ensures that nothing gets forgotten ina busy working environment.

Dialog+ – Technology serving users and patients.

Dialog_engl_innen_copy.qxd 06.06.2007 7:56 Uhr Seite 4

Intuition meets high-tech

Hemodialysis

Devoting more care to patients ...

… and expending less outlay on documentation. Less administration means the staff has more time to devote topersonal attention. The biggest advance in hemodialysis has been to create a greater proximity to the patient.

Dialog+ – Benefits

■ Ergonomic design for simplified handling

■ Quicker therapy induction and less paper work

■ User-friendly operator guidance

■ Straightforward menu navigation createsuser confidence

■ Simplified priming and disinfection

Dialog_engl_innen_copy.qxd 06.06.2007 7:56 Uhr Seite 5

– Your quality manager

Top quality management …

... that can be feasibly implemented in daily routine is a critical factor for today's and tomorrow's customers. The intelligent technology and logical safety concept built into Dialog+ are synonymous with quality management, added value and low overhead costs.

Multi-level safety concept reduces risk

The unique, multidimensional safety concept on Dialog+ provesthat ultimate safety, country- and user-specific customizationand personalized therapy are not contradictions in terms. Thisbalance between minimum risk and maximum flexibility isachieved in many ways, for example, through the bi-channelhard- and software safety system, and the versatile configuration options available with the TSM mode.

Added safety features include the no-nonsense system ofprompts and alarms with the integrated help function, whichgives users clear, unmistakable instructions on how to act.Additionally, Dialog+ is equipped with a well-structured emergency management system. In the event of an emergency,the Bypass and Min UF symbols can be activated instantaneouslyby simply pressing a button. If the patient experiences a hypotensive episode, the bolus function delivers an automaticbolus infusion – fast and trouble-free.

Other preventive risk reduction functions include the automaticdialyzer inlet pressure (PBE) monitoring for secondary membrane formation in the dialyzer and the early detection offilter clotting and kinks in the bloodlines that prompt the initiation of appropriate hemolysis prophylaxis.

Patient-personalized dialysis profiles

Effective dialysis treatment must be as individual as eachpatient. The software in Dialog+ reacts to each patient's personalneeds. The user can infinitely combine the six different treat-ment profiles. This function allows ultrafiltration, conductivity,bicarbonate, dialysis flow rate, temperature and heparin dosingto be ideally personalized for each patient.

A variety of options: Three single-needle procedures

In patients with multimorbidity and vascular problems, the indication for permanent single-needle (SN) dialysis is being rendered more and more frequently. Hence, the SN cross-overfeature delivers a continuous SN treatment to achieve the highest efficiency. With Dialog+, three SN procedures are possible: SN-KK, SN valve, SN cross-over.

The unique SN cross-over procedure: This pressure-pressure driven double pump SN system is one of a kind. Compared to conventional SN systems, it helps maintain continuous blood flowand relatively constant pressure conditions in the dialyzer.Operation involves simply setting the blood pump rate and adjusting the pressure limits. Afterwards, the settings are storedon Dialog+ therapy cards.

Transparency with Kt/V graphics

As a reliable and no-cost method for monitoring treatment quality, Dialog+ continually calculates the Kt/V throughout therapy. The operator automatically receives a graphic displayof the Kt/V profile and an indication about how close it is tothe target. Fluctuations in the predicted curve caused by changes in variables affecting Kt/V are visible at a glance.

Cross-over procedure

DialyzerArterial blood pump Venous blood pump

Venous tubing clampArterial tubing clamp

Arterialexpansionchamber

Venousexpansionchamber

AP VP

Dialog_engl_innen_copy.qxd 06.06.2007 7:56 Uhr Seite 6

Safety meets flexibility

Hemodialysis

Our patients ...

... trust in us because they know that their safety and securityare paramount. Of course, like everybody else, we have to verifythe quality of our treatments. Modern-day dialysis centers arebecoming subject to ever more stringent regulations for traceable and transparent quality management. Sophisticated,high-tech accessories and features make it easier for us tosatisfy all legal and regulatory requirements.

Dialog+ – Benefits

■ Unique safety concept

■ Mature technology

■ Personalized therapy

■ Automatic documentation

Dialog_engl_innen_copy.qxd 06.06.2007 7:56 Uhr Seite 7

– Your systems partner

Process-safety and integrated systems …

… are what our customers have appreciated in B. Braun for deca-des. From filters and dialysis machines to technical advice, weoffer our contractors the full range of services and products - inB. Braun branded quality. Our customers know they can rely onB. Braun's performance. And we always listen and take to heartwhat our customers have to say. We maintain an ongoing dialogwith our partners – worldwide.

Option Nexadia® BSL1

With the Nexadia® BSL option, Dialog+ can be linked to theinnovative Nexadia® data management system. This advancedbenchmark information technology supports users and makestheir routine work significantly easier. At the same time, thisoption improves the quality of dialysis treatments, streamlinesworkflows and documents all relevant data. All of which converts to true savings against mounting cost pressures.

In combination with the Dialog+ hemodialysis machine, the useof Nexadia® sustainably improves therapy. The operator can usethe screen on the dialysis machine as an input terminal, supplemental to an external workstation e.g. a Client PC.Moreover, the bidirectional exchange of text messages, druginstructions etc. is possible via the message exchange function.

The bioLogic RR® Comfort2 optionThis biofeedback system for automatic blood pressure stabilizationis globally unique. bioLogic RR® Comfort directly measures thepatient's blood pressure and automatically and intelligentlyregulates the UF rate according to the principle of fuzzy logic. 3

The innovative Guideline Technique is based on individual datastorage and markedly reduces the need for regular blood pressuremeasurements. Clinical evidence has confirmed that the use ofbioLogic RR® Comfort 4 leads to a significant reduction in hypo-tension-related side effects. The result is enhanced treatmentcomfort for patients and less stress for the nursing staff.

bioLogic RR® Comfort requires virtually no adjustment effort. All the settings required by the medical staff are limited to setting the lower systolic blood pressure limit and the maximumUF rate. Beyond this, the Dialog+ screen displays an understand-able graphic at all times. The economical aspects of bioLogicRR® Comfort are similarly compelling. It can be used with justone blood pressure cuff. That helps save on consequential costs.

Because life is full of diversity ...… we have equipped Dialog+ with a huge range of customer-specific variants and options.

1 BSL stands for Bed Side Link, a chip card reader with integrated network functionality. This option enables Dialog+ to be run within a network.

2 RR stands for Riva-Rocci (the person who, in 1896, invented the original blood pressure apparatus with cuff and mercury pressure gauge, the Riva-Rocci sphygmomanometer, first used to noninvasively measure arterial pressure).

3 Mancini E, Mambelli E, Irpinia M et al.: Prevention of dialysis hypotension episodes using fuzzy logic control system. Nephrol Dial Transplant (2007) 22 (5): 1420-1427

4 Roeher O, Schmidt R, et al.: biologicRR Comfort significantly reduces hypotensive episodes in patients prone to intradialytic hypotension. 38th Congress of the German Society of Nephrology, Munich, 2007

Dialog_engl_innen_copy.qxd 06.06.2007 7:57 Uhr Seite 8

Sharing Expertise

B. Braun – A visionary on the healthcare market

Dialog+ was developed from a synergy of expertise and heritage by one of the leading corporations on the healthcare market.Backed by a 166-year history of industrial innovations and power,the company's well-balanced portfolio is stocked with over30,000 products that are sold in 50 countries on all 5 continents.Over 32,000 employees work for the B. Braun group globally. It is they who have made a major contribution to its success: In 2006, corporate revenues exceeded three billion euros.

Corporate structure: Structured competency

The group is organized into four divisions. Each division's products and services address different areas of medicine andtherapy. B. Braun Avitum develops and manufactures systems forextracorporeal blood treatment and operates dialysis centers inEurope, Asia and Africa. Hospital Care is an innovative developerof product and service concepts for hospitals. Out Patient Market(OPM) provides solutions for private medical practices and thehomecare market. Aesculap specializes in surgical core processes.The expertise of these four divisions is bundled into a competentwhole. B. Braun, a global corporation that unites convincing performance with competent leadership. B. Braun. More than the sum of its parts.

Dialog+ – Evolutionizing hemodialysisDriven by our motto, “Sharing Expertise”, we have always maintained a worldwide dialog with our customers, partners andmedical researchers. That's why we named our latest and mostinnovative hemodialysis system Dialog+. Our mission is to developsolutions that not only sustainably improve, but also evolutionizehealthcare. Excellent communication and visionary thinking areneeded if we want to move forward in our evolutionary development.

Dialog+ – The original from B. Braun

Decades of dialysis innovations

For decades, B. Braun has been improving the life of dialysis pati-ents around the globe with its innovative products and dependable services. For example, back in 1982, B. Braun intro-duced the HD 105, the first hemodialysis machine that measuredultrafiltration both up- and downstream from the dialyzer. Thistechnology enabled an improvement in dialysis safety. Twelveyears later, the Dialog dialysis machine, the predecessor toDialog+, was the first to feature convenient touch screen operation.These are just two notable examples of how B. Braun's visionshave been shaping the future of extracorporeal blood treatment.

Dialog+ embodies integration

Today, with Dialog+, B. Braun is again raising the bar in the fieldof hemodialysis. In Dialog+, intelligent software is perfectly integrated into sophisticated high-grade, hardware-equipped original accessories. As with every one of our products, every purchase is backed by excellent service support and dependableglobal logistics. When you acquire the world's most advancedhemodialysis system, you are buying the embodiment of our corporate values: innovation, efficiency and sustainability. Invest in the future. Invest in Dialog+ – The original from B. Braun.

Nexadia®: This innovative datamanagement solution stream-lines workflows - sustainably. Allpatient- and treatment-relateddata, equipment settings andother relevant information arecompiled, consolidated and stored. For the ultimate in process efficiency.

Hemodialysis

Sophisticated communications

A dialog ...

... only makes sense if it leads to better understanding. WithDialog+, we at B. Braun have proven how much we understandthe process of dialysis, the constraints of the market, thedemands of our customers and needs of our patients.

The result is

■ Sustainability based on future-proof concepts

■ Efficient work through automation andnetworking

■ Maturity of experience and proven solutions

■ Quality assurance through smart technology

■ Innovation created together with ourcustomers

The synergies of integrated systems

Dialysis centers: B. BraunAvitum never loses sight of itscommitment to practical appli-cation and patient proximity –just one of the reasons why weoperate dialysis centers inEurope, Asia and Africa. AtB. Braun Avitum centers, dialysispatients receive the highestlevel of healthcare worldwide.

Catheters: Haemocat® Signo,the catheter for extracorporealblood treatment, offers usersthe option of EKG-guidedcatheter positioning. Thismeans simplicity with maximum safety.

Diacap® � Polysulfone:The new dialyzer generation ofpolysulfone fibers meets thespecific requirements of themost complex of regimensranging up to and includingefficient high-flux hemodiafil-tration.

The innovative solutions from B. Braun are synonymous withexcellent medical care and streamlined clinical routines. Ourcustomers acquire integrated systems designed with perfectlycoordinated components.

Needles: Needlestick preventi-on in dialysis is gaining evermore importance. With thedevelopment of new needles forextracorporeal blood treatment,we are doing justice to thisneed. The Diacan® S safetyneedle with an integrated safety clip provides effectiveprotection.

Our customers benefit from a full-range of services including technical support, process advice, business management, consulting,planning, development, installation and training courses – all backedby the vast expertise of one of world's largest medical productscompanies.

A/V systems: Bloodlinesystems made of biocompatible,proven and innovative plasticizer-free componentsare the lifeline between pati-ent and dialyzer.

Solutions: B. Braun was thefirst manufacturer in Germanyto develop bicarbonate-buffered hemofiltration solutions. That this benefitspatients by reducing cardiovascular complicationshas been proven in clinicalstudies.

Concentrates: B. Braun produces a wide range of liquidacidic and alkaline bicarbonate-buffered hemodialysis concentrates for personalizedtreatment regimens. The Sol-Cart B® cartridge containingsodium hydrogen carbonatepowder is just one practicalalternative for users.

Dialog_engl_aussen_copy.qxd 06.06.2007 8:01 Uhr Seite 2

Sharing Expertise

B. Braun – A visionary on the healthcare market

Dialog+ was developed from a synergy of expertise and heritage by one of the leading corporations on the healthcare market.Backed by a 166-year history of industrial innovations and power,the company's well-balanced portfolio is stocked with over30,000 products that are sold in 50 countries on all 5 continents.Over 32,000 employees work for the B. Braun group globally. It is they who have made a major contribution to its success: In 2006, corporate revenues exceeded three billion euros.

Corporate structure: Structured competency

The group is organized into four divisions. Each division's products and services address different areas of medicine andtherapy. B. Braun Avitum develops and manufactures systems forextracorporeal blood treatment and operates dialysis centers inEurope, Asia and Africa. Hospital Care is an innovative developerof product and service concepts for hospitals. Out Patient Market(OPM) provides solutions for private medical practices and thehomecare market. Aesculap specializes in surgical core processes.The expertise of these four divisions is bundled into a competentwhole. B. Braun, a global corporation that unites convincing performance with competent leadership. B. Braun. More than the sum of its parts.

Dialog+ – Evolutionizing hemodialysisDriven by our motto, “Sharing Expertise”, we have always maintained a worldwide dialog with our customers, partners andmedical researchers. That's why we named our latest and mostinnovative hemodialysis system Dialog+. Our mission is to developsolutions that not only sustainably improve, but also evolutionizehealthcare. Excellent communication and visionary thinking areneeded if we want to move forward in our evolutionary development.

Dialog+ – The original from B. Braun

Decades of dialysis innovations

For decades, B. Braun has been improving the life of dialysis pati-ents around the globe with its innovative products and dependable services. For example, back in 1982, B. Braun intro-duced the HD 105, the first hemodialysis machine that measuredultrafiltration both up- and downstream from the dialyzer. Thistechnology enabled an improvement in dialysis safety. Twelveyears later, the Dialog dialysis machine, the predecessor toDialog+, was the first to feature convenient touch screen operation.These are just two notable examples of how B. Braun's visionshave been shaping the future of extracorporeal blood treatment.

Dialog+ embodies integration

Today, with Dialog+, B. Braun is again raising the bar in the fieldof hemodialysis. In Dialog+, intelligent software is perfectly integrated into sophisticated high-grade, hardware-equipped original accessories. As with every one of our products, every purchase is backed by excellent service support and dependableglobal logistics. When you acquire the world's most advancedhemodialysis system, you are buying the embodiment of our corporate values: innovation, efficiency and sustainability. Invest in the future. Invest in Dialog+ – The original from B. Braun.

Nexadia®: This innovative datamanagement solution stream-lines workflows - sustainably. Allpatient- and treatment-relateddata, equipment settings andother relevant information arecompiled, consolidated and stored. For the ultimate in process efficiency.

Hemodialysis

Sophisticated communications

A dialog ...

... only makes sense if it leads to better understanding. WithDialog+, we at B. Braun have proven how much we understandthe process of dialysis, the constraints of the market, thedemands of our customers and needs of our patients.

The result is

■ Sustainability based on future-proof concepts

■ Efficient work through automation andnetworking

■ Maturity of experience and proven solutions

■ Quality assurance through smart technology

■ Innovation created together with ourcustomers

The synergies of integrated systems

Dialysis centers: B. BraunAvitum never loses sight of itscommitment to practical appli-cation and patient proximity –just one of the reasons why weoperate dialysis centers inEurope, Asia and Africa. AtB. Braun Avitum centers, dialysispatients receive the highestlevel of healthcare worldwide.

Catheters: Haemocat® Signo,the catheter for extracorporealblood treatment, offers usersthe option of EKG-guidedcatheter positioning. Thismeans simplicity with maximum safety.

Diacap® � Polysulfone:The new dialyzer generation ofpolysulfone fibers meets thespecific requirements of themost complex of regimensranging up to and includingefficient high-flux hemodiafil-tration.

The innovative solutions from B. Braun are synonymous withexcellent medical care and streamlined clinical routines. Ourcustomers acquire integrated systems designed with perfectlycoordinated components.

Needles: Needlestick preventi-on in dialysis is gaining evermore importance. With thedevelopment of new needles forextracorporeal blood treatment,we are doing justice to thisneed. The Diacan® S safetyneedle with an integrated safety clip provides effectiveprotection.

Our customers benefit from a full-range of services including technical support, process advice, business management, consulting,planning, development, installation and training courses – all backedby the vast expertise of one of world's largest medical productscompanies.

A/V systems: Bloodlinesystems made of biocompatible,proven and innovative plasticizer-free componentsare the lifeline between pati-ent and dialyzer.

Solutions: B. Braun was thefirst manufacturer in Germanyto develop bicarbonate-buffered hemofiltration solutions. That this benefitspatients by reducing cardiovascular complicationshas been proven in clinicalstudies.

Concentrates: B. Braun produces a wide range of liquidacidic and alkaline bicarbonate-buffered hemodialysis concentrates for personalizedtreatment regimens. The Sol-Cart B® cartridge containingsodium hydrogen carbonatepowder is just one practicalalternative for users.

Dialog_engl_aussen_copy.qxd 06.06.2007 8:01 Uhr Seite 2

Efficient processes. Innovative therapies.Streamlining workflows.

Dialog with the future

B. Braun Medizintechnologie GmbH

Schwarzenberger Weg 73-7934212 MelsungenGermanyTel +49(0) 56 61 71-3716Fax +49(0) 56 61 75-3716

www.bbraun-dialysis.comW. 02.10.08/2 No. 708 0075A Edition: 10/2008

Potential through individuality

Hemodialysis

The ABPM OptionThe automatic blood pressure measurement or ABPM option ensures dependable monitoring of your patients. Automatically,accurately and non-invasively, Dialog+ measures blood pressureusing the oscillometric method. This takes a burden off the staffand enhances safety for your patients.

The benefits of the ABPM option

n Easy BP measurement at all times – before, during and after dialysis

n Automatic readings at regular intervalsn BP and pulse rate are clearly displayed on the main screenn Alarm limits can be individually adapted to patient's blood

pressure by pressing a buttonn Selectable color display for blood pressure and pulse curvesn Real-time documentation of all readingsn Automatic cuff inflation adjustment

Dialysis fluid filter optionThe dialysis fluid filter option is used to significantly improve thequality and purity of the dialysis fluid delivered by the dialysismachine. In an additional filtration stage, the dialysis fluid ispumped through the Diacap® Ultra dialysis fluid filter to filterand absorb any microbial impurities from the dialysate.

Obviously, treatment with ultrapure dialysis fluid has clinicaladvantages. Chronic inflammatory processes triggered by pyrogen impurities (cytokine-induced formation of interleukin,TNF, �2-microglobulin amyloidosis etc.) are markedly reduced.This reduction is associated with a positive effect on the pati-ent's general, nutritional and cardiovascular status.

The dialysis fluid filter option lets you significantly improve thequality of the dialysis treatment. Consequently, you promotepatient's health and extend their life expectancy. At the sametime, you achieve a high savings potential by preventing againstlikely complications and the consequential costs associated withthem.

Option HDF OnlineWith the Dialog+ Online version, you can carry out high-volumehemodiafiltration with substitution solutions manufactured bythe dialysis machine online. The solution is made from the dialysis fluid that is put through an additional 2-stage filtrationcycle run through two sequentially connected Diacap® Ultra dialysis fluid filters.

Combining diffusive and convective clearance improves the elimination of small and medium-sized molecules. Likewise, HDFOnline is also suitable for patients with unstable cardiovascularstatus who tend to experience a strong drop in blood pressureeven at low ultrafiltration volumes.

It is important that all features and accessories fit …… I want to be able to leverage my options – now and in the future.

Hem

odia

lysi

s

umschl_dialog_plus_6s_gb.qxd 30.09.2008 8:55 Uhr Seite 1

Efficient processes. Innovative therapies.Streamlining workflows.

Dialog with the future

W. 01.10.08/2 No. 708 0075A Edition: 10/2008

Potential through individuality

Hemodialysis

The ABPM OptionThe automatic blood pressure measurement or ABPM option ensures dependable monitoring of your patients. Automatically,accurately and non-invasively, Dialog+ measures blood pressureusing the oscillometric method. This takes a burden off the staffand enhances safety for your patients.

The benefits of the ABPM option

n Easy BP measurement at all times – before, during and after dialysis

n Automatic readings at regular intervalsn BP and pulse rate are clearly displayed on the main screenn Alarm limits can be individually adapted to patient's blood

pressure by pressing a buttonn Selectable color display for blood pressure and pulse curvesn Real-time documentation of all readingsn Automatic cuff inflation adjustment

Dialysis fluid filter optionThe dialysis fluid filter option is used to significantly improve thequality and purity of the dialysis fluid delivered by the dialysismachine. In an additional filtration stage, the dialysis fluid ispumped through the Diacap® Ultra dialysis fluid filter to filterand absorb any microbial impurities from the dialysate.

Obviously, treatment with ultrapure dialysis fluid has clinicaladvantages. Chronic inflammatory processes triggered by pyrogen impurities (cytokine-induced formation of interleukin,TNF, �2-microglobulin amyloidosis etc.) are markedly reduced.This reduction is associated with a positive effect on the pati-ent's general, nutritional and cardiovascular status.

The dialysis fluid filter option lets you significantly improve thequality of the dialysis treatment. Consequently, you promotepatient's health and extend their life expectancy. At the sametime, you achieve a high savings potential by preventing againstlikely complications and the consequential costs associated withthem.

Option HDF OnlineWith the Dialog+ Online version, you can carry out high-volumehemodiafiltration with substitution solutions manufactured bythe dialysis machine online. The solution is made from the dialysis fluid that is put through an additional 2-stage filtrationcycle run through two sequentially connected Diacap® Ultra dialysis fluid filters.

Combining diffusive and convective clearance improves the elimination of small and medium-sized molecules. Likewise, HDFOnline is also suitable for patients with unstable cardiovascularstatus who tend to experience a strong drop in blood pressureeven at low ultrafiltration volumes.

It is important that all features and accessories fit …… I want to be able to leverage my options – now and in the future.

Hem

odia

lysi

s

B. Braun Avitum AG

Schwarzenberger Weg 73–7934212 MelsungenGermanyTel +49 (56 61) 71-26 24Fax +49 (56 61) 75-26 24

e-mail: [email protected]

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