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POSITIONS OPEN

NEUROBIOLOGISTASSISTANT/ASSOCIATE PROFESSOR

The Department of Neurobiology and Anatomy in-vites applications for a tenure-track faculty position.Applicants should have postdoctoral experience, a strongrecord of scholarship. The Department is seeking anoutstanding individual who is using modern systems,cellular, or molecular approaches in an area of researchthat complements that of current faculty. Particularpreference will be given to those individuals interested inthe mechanisms by which the CNS combines and inte-grates information from the different sensory modalities.Research interests of the faculty include multisensoryintegration, sensory systems of development and organi-zation, retinal biology, neurodegeneration, neuronal andsynaptic plasticity, neuron-glial interactions, aging, pro-grammed cell death, trophic factors, and axonal growthand projections. The Bowman Gray School of MedicineofWake Forest University offers a unique opportunity tointeract with a broad range of neurobiologists thatcomprise part of a strong and active interdisciplinaryPh.D. Program in Neuroscience. Send curriculum vitae,description of research and three letters of recommenda-tion to: Dr. Barry E. Stein, Chairman of the Depart-ment of Neurobiology and Anatomy, Bowman GraySchool of Medicine, Wake Forest University, Win-ston-Salem, NC 27157-1010.AffirmativeAction/EqualOpportunity Employer.

ASSISTANT AND ASSOCIATE PROFESSORVERTEBRATE DEVELOPMENTAL BIOLOGYApplications are invited for a tenure track position in

the Department of Biological Structure at the Universityof Washington School of Medicine. Applicants shouldhave a Ph.D. or M.D. degree with at least three years ofpostdoctoral experience. The successful candidate will beexpected to establish a vigorous, externally funded re-search program in the area of vertebrate developmentand participate in graduate education in this field. Appli-cants should also be willing to contribute to team-taughtcourses in human anatomy/embryology or neurosciencefor health professionals. Candidates should send curric-ulum vitae, a description of research interests, and threeletters of reference by September 15, 1994, to: Dr.Thomas Reh, Search Committee Chair, Departmentof Biological Structure, SM-20, University of Wash-ington, ttle, WA 98195. The University ofWashing-ton is an Affirmative Action/Equal Opportunity Employer.

ENVIRONMENTAL STUDIES POSITIONS

Mount Holyoke College seeks to fill two separateone-semester visiting professor positions in environmen-tal studies: one each for the fall 1995 and fall 1996.Candidates should be accomplished senior scholars inareas related to environmental studies and may be fromthe natural sciences, social sciences or humanities. Thespecific field is not as important as a strong interest in

interdisciplinary approaches to environmental problemsand an ability to communicate with other scholars across

disciplines. The visiting scholar will teach the seniorseminar in environmental studies and take part in a livelyprogram ofcampus talks and collegial discussion devotedto environmental studies. Opportunities for interactionwith faculty in the other colleges in the Five-College area

(Amherst, Smith, UMass, and Hampshire) are also avail-able. Mount Holyoke is committed to cultural diversity and isan Equal Employment Opportunity and Affirmative Actionemployer. Women and minorities are especially encouraged toapply. The evaluation of applications will begin onOctober 1, 1994. Send a letter of application, curriculumvitae, and letters of reference to: Jens Christiansen,Chair, Environmental Studies Program, Mount Ho-Iyoke College, South Hadley, MA 01075.

The department of Anatomy at Nova SoutheasternUniversity invites applications for two full-time positionsopen at the ASSISTANT OR ASSOCIATE PRO-FESSOR level. Applicants will be considered beginningAugust 1, 1994. The candidates must have a Ph.D. orequivalent degree and teaching experience in humananatomy. The primary duties will be to assist in theteaching of human gross anatomy to students in themedicalg, optometry and allied health programs.

Please send curriculum vitae and a list of three refer-ences to: Gerald R. Conover, Ph.D., Department ofAnatomy, Health Professions Division, Nova South-eastern University, 1750 N.E. 167th Street, NorthMiami Beach, FL 33162-3017.

POSITIONS OPEN

ASSISTANT PROFESSORTENURE-TRACK

DEVELOPMENTAL NEUROBIOLOGYUCLA

Applications are being solicited for two tenure-trackpositions in the UCLA Brain Development and MentalRetardation Research Center. Applicants must have 2 ormore years of postdoctoral experience and are expectedto establish an independent research program. The Cen-ter is seeking outstanding scientists with a background incellular and molecular neurobiology and an interest inbrain development and related dysfunctions. Candidateswith a track record in the molecular and/or cellularneurophysiological analyses of mammalian CNS devel-opment are particularly encouraged to apply. Joint appointment in a basic science department relevant to thecandidate's background will be ible. Send applica-tions, together with a statement abut present and futureresearch interests, three most significant reprints and thenames of three referees to: Faculty Search Committee,c/o Dr. Jean de Vellis, Director, Brain Developmentand Mental Retardation Research Center, 68-225NPI, UCLA, 760 Westwood Plaza, Los Angeles, CA90024-1759. An Equal Opportunity Employer.

ASSISTANT/ASSOCIATE PROFESSORMOLECULAR BIOLOGY/TOXICOLOGY

The Division ofToxicology, Department ofPharmacolo-gy and Toxicology, University of Arkansas for MedicalSciences (UAMS) is recruiting a full-time tenure-track facul-ty position to join the growing division at the ASSISTANTor ASSOCIATE PROFESSOR level. Requirements in-clude: a Ph.D. or equivalent degree, postdoctoral training,and a productive record of quality research. Applicantsshould be utilixing molecular approaches to solve basicproblems in any area of toxidcogy or pathophysiology.Individuals interested in neurotoxicology are encouraged toapply. Applicants are expected to develop an independentresearch program with extramural funding. Individuals ap-plying at the Assoiate Profsor level should have extramu-oratfiveing..rExcellen oppornmitie are available for collab-

oratve eserchwit oter AMSfacltyand admuitfaculty at the National Center for Toxicological Researchlocated nearby. A competitive start-up package, and researchspace in a newly constrcted research building are available.Send curriculum vitae, a brief research prspecus and thenames ofthree references to: Rick G. Sc PhD.,Division ofToxkiogy, Slot 638, UniversityofArkansasfor Medical Sciences, itde Rock, AR 72205, Tde-phone: (501) 686-8883, FAX (501) 686-8970. Appli-cations received before September 1, 1994, are assured ofconsideration. UAMS is an Equal Opportunity/AfirmativeAction Employer.

ASSOCIATE PROFESSORS/PROFESSORSDEVELOPMENTAL BIOLOGYMOLECULAR CELL BIOLOGY

The Institute of Biological Sciences at the Universityof Tsukuba, Tsukuba Science City, Japan, invites appli-cants for two tenure-track positions for associate profes-sors/full professors with expertise in (1) moleca andgenetic aspects of developmental biology and (2) molec-ular biology of the nucleus and organelle(s). The success-ful applicants are expected to develop their own researchas welas to teach graduate and undergraduate courses ingeneral biology and developmental biology, or molecularand cellular biology, respectively, starting on 1 April1995. Salary will be in line with the regulations set outfor Faculty of a Japanese National University, dependingon experience.

Applicants should send a letter describing their interestin me position, curriculum vitae, a list of publishedpapers, and reprints of 5 recent representative works andarrange for the delivery of three referees' reports by 7October 1994, to: Professor Tamio Hirabayashi,Chair, Institute of Biological Sciences, University ofTsukuba, Tsukuba Science City 305, Japan. Generalenquiries are welcome to: FAX: 81-298-53-6649;Email: tamio@sakura.cc.tsukubaacjp. The appoint-rnent will be tmade independent ofsex, religion, or nationality,but ability to conduct classes in Japanese is preferable.

Several RESEARCH POSITIONS available inDNA Probe Development with this Maryland basedcompany. B.S., M.S., Ph.D. in molecular biology pre-ferred. Seeking extensive experience with PolymereseChain Reaction technique, DNA sequencing, enzymepreparation, biofurmentation, recombinant reagent de-velopment. Excellent salary/benefits. Send resumes: Unit142, 532 Old Marlton Pike, Marlton, NJ 08053.

SCIENCE * VOL. 265 * 15 JULY 1994

CONDITIONS: Personnel advertising isaccepted only with the understanding that theadvertisers do not discriminate amongapplicants on the basis of race, sex, religion,age, color, handicap or sexual preference.The AAAS encourages employers to activelyrecruit and employ underrepresentedminority groups. Science reserves the right,at its discretion, to decline to publishadvertisements submitted to it.

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POSITIONS OPEN

ENDOWED PROFESSORSHIPIN CARDIOVASCULAR DISEASE

TULANE UNIVERSITYThe Cardiology Section of Tulane University is seek-

ing applications and nominations for the position ofProfessor and holder of the Sidney and Marnlyn LassenChair in Cardiovascular Disease. Both physicians andscientists with a record of academic excellence in thecardiovascular field commensurate with an endowedacademic appointment will be considered. Applicantsshould send curriculum vitae and 3 letters ofreference to:Andrew J. Buda, M.D., Robert Morgandanes Profes-sor of Medidne, Chie Section of Cardiology, De-partment of Medicne, 1430 Tulane Avenue, NewOrleans, LA 70112-2699. FAX.: (504) 587-4237.Affirmative Action/Equal Opportunity Employer. Applica-tions accepted until position filled.FACULTY POSITIONS. The Departme of Micro-

biology and Immunology, and the Program in MolcularMediane of the University of Calibmia, San Francisco,School of Medicine, are seeking ou i candidates tofill two tue-trac or tenured positions. In addition todeparimentalaffiliation, the positions inudemembrship inthe Program in Bioogical Sciences, the cellent campuwide graduate p The search will consider candidateswith creativity and research productivity inmolecularor celllar immunology. Rankwill becommensu-rate with level of e n. Inesed candidates shouldsend curriculum vitae and a s n of future researchplans, and have three leters of rcmm datio sent bySeptebe 1, 1994, to: M w kS tCn hcdo Joan Jenkin, y& Inmu-noogy, Box 041 of , San Frn-cisce, San Fraisc, CA 94143. UC is an Equal Opportu-nity/Affimave Action Employer. Women and minorities areencouraged to apply.

FACULTY POSITIONS INMOLECULAR MICROBIOLOGY AND

MOLECULAR GENETICSTECHNION - ISRAEL INSTITUTE OF

TECHNOLOGYThe B. Rappaport Faculty of Medicine at the Tech-

nion invites applications for tenure-track positions at thesenior lecturer to professor leve in all areas ofMolecularMicrobiology. Applications are also invited for tenure-track positions at the senior lecturer to professor level inMolecular Genetics, preferably human or mammaliangenetics. Applicants are expected to conduct independentresearch ofhigh 9uality and toteach undergraduate andgraduate courses m their areas of expertise. Please submitcurriculum vitae, a brief statement of research directionsand names of three references to: Professor PeretzLavie, Dean, B. Rappaport Faculty of Medicine,Technion, P.O. 9649,Bat Galim, Haifa 31096 Israel.

FACULTY POSITIONS-TULANE UNIVERSITY

As part of an ongoing environmental restoration andwaste management research program, Tulane UniversitySchool of Public Health and Tropical Medicine invitesapplications for several positions at the ASSISTANT orASSOCIATE PROFESSOR rank in the Departmentof Environmental Health Sciences. The positions areinitially funded as research faculty appointments withpossibility ofconversion to tenure track. Research will becarried out in the newiy established ENTERGY SpatialAnalysis Research Laboratory, part of the Tulane Centerfor Bioenvironmental Research. Openings in the follow-ing areas are available immediately: (Position 1) RiskAssessment/Radiation Effects; (Position 2) ExposureAssessment; (Position 3) Ecological Risk Assessment;(Position 4) EnvironmentalResource Economics. Ap-plicants should hold an earned doctorate in environmen-al toxicology, risk assessment, economics, ecology, radi-ation health, or relted disciplines. Experience with de-cision analysis, geographic information systems (GIS),and modeling is desirable. Review of applications willcontinue until the positions are filled, but to insureconsideration for the positions, materials should besubmitted by August 1 , 1994. Applicants should des-ignate the position number for which they are applyingand send their curriculum vitae, brief description ofresearch interests, 3 samples ofwritten work, an arrangefor three letters of reference to: William A. Toscano, Jr.,Ph.D., Chair, Environmental Health Sciences De-partent, Tulane University School of Public Healthand Tropical Medicine SL-29, 1430 Tulane Avenue,New Orlans, LA 70112-2699.

POSITIONS OPEN

FACULTY POSITION FOR VIROLOGIST

The Department of Neurology of the Johns HopkinsUniversity School of Medicine seeks applications for atenure-track position at the level of INSTRUCTOR, orASSISTANT or ASSOCIATE PROFESSOR. Appli-cants must have a relevant Ph.D. or M.D. degree and atleast 2 years of postdoctoral training plus experience inmolecular biology and retrovirology. Candidates willhave an opportunity to collaborate with an ongoingproject focusing on the neurological manifestations ofAIDS and to develop an independent research program.Send curriculum vitae, description of research experienceand proposed research, and names/addresses of73 refer-ences to: Dr. Richard T. Johnson M.D., Chairman,Department of Neurology, Johns Hopkins Hospital,600 N. Wolfe St., Baltmore, MD 21287-7609. AnEqual Opportunity/Affirmative Action Employer.

FACULTY POSITIONMemorial Sloan-Kettering Cancer Center

The Program in Molecular Pharmacology and Thera-peutics invites applications for tenure- positions atthe ASSISTANT or ASSOCIATE MEMBER level.We are seeking innovative individuals with strong re-search accomplishments and outstanding promise, whowill use modern molecular and biochemical approachesto address problems of pharmacological relevance.

Applicants should have a Ph.D. and/or M.D. degree, astrong postdoctoral education, and a commitment toexcellence in research. MSKCC offers a unique andexciting research environment and will provide generousstart-up support. By Oct. 1, 1994, candidates shouldsend their curriculum vitae as well as a description ofcareer goals, research objectives and the name of threescientists who can evaluate the applicants accomplish-ments and potential to: Joseph R. Bertino, M.D.,Program Chairman, Molecular Pharmacology andTherapeutics Program, Memorial Sloan-KetteringCancer Center-Box 78, 1275 York Avenue, NewYork, NY 10021. Memorial Sloan-Ketring Cancer Cen-ter is an Affirmative Anion/Equal Opportunity Employer.

POSTDOCTORAL POSITION available immedi-ately for research on the cell biology of the growth ofneuronal processes. Projects involve the use of videomicroscopy combined with biochemical and molecularbiological techniques. Background in neurobiology and/or cell biology preferred. Send curriculum vitae, state-ment of research experience and interests, and names ofthree references to: Dr. Daniel J. Goldberg, Depart-ment of Pharmacology, Columbia University, 630West 168th Street, New York, NY 10032. EqualOpportunity/Affrmative Action Employer.TWO POSTDOC1ORAL POSMONS are available

to study: 1) Regulation ofPKCs and PKC binding proteinsin tumor pr (See: JBC 268:6858 (1w93)); 2)Domain mapping and protein interaction of a novel diacyl-giycerol kinase. Please send curriculum vitae, a statement ofresearch iuntts andexperience, and the names and address-es of three references to: Dr. Susan Jaken, 04 PersonnelDepartmentW.AlionJonesCelScoenceCenter, 10 OldBarn Road, Lake Placid, NY 12946. Afimtve Action-Equal Opportunity Employer.

THE UNIVERSITY OF UTAH ANDTHE HUNTSMAN CANCER INSITITUTE

FACULTY POSITIONS IN THE MOLECULARBIOLOGY AND GENETICS OF CANCER

The Health Sciences Center at the University of Utahseeks tenure-track faculty candidates at the ASSISTANTor ASSOCIATE PROFESSOR level for multiple positions in the Department of Cellular, Viral and Molec-ular Biology. The positions are available immediately andwill be supported by the new Huntsman Cancer Instituteand its programs in breast, prostate, colon and lungcancer.The successful applicant will have demonstrated re-

search excellence in the molecular biology and genetics ofcell systems. Preference will be given to applicants com-mitted to the exploration of human cancer in such fieldsas signal transduction, cell cycle, cell adhesion, cytoskel-etal regulation, cell differentiation and genomic stability.The University is an Equal Opportunity/Affirmative Ac-

tion Employer. Women, minority and international candidatesare encouraged to apply. Letters of interest, curriculumvitae, and names of three references should be sent to:Ray White, Director, Huntsman Cancer Institute andChairman, CVMB Department, University of Utah,Bldg. 533, Suite 7410, Salt Lake City, UT 84112.

POSITIONS OPEN

FACULTY POSITIONMACROPHYTE ECOLOGY

The Rosenstiel School of Marine and AtmosphericScience, University of Miami, invites applications for atenure-track position at the ASSISTANT to FU LLPROFESSOR level in the area of marine or estuarinemacrophyte ecology andlor physiology. Preference givento candidates with both experimental and communitymodeling skills, experience in warm temperate or tropicalecosystems, demonstrated abilit in research, and stronginterest in teaching. Responsibilities include establishinga strong, externally funded research program, preferablyfocused on ecosystems of South Florida/Caribbean, di-recting graduate students, and teaching introductory andadvanced graduate courses. Applicants should forwardcurriculum vitae, statement of research and teachinginterests, and names of references to: MacrophyteSearch Committee, Division of Marine Biology andFisheries, RSMAS, 4600 Rickenbacker Causeway,Miami, FL 33149-1098, by 15 August 1994.The University of Miami is an Equal Opportunity!

Affirmative Action Employer.

FACULTY POSITIONTHE WEIZMANN INSTITUTE OF SCIENCEThe Department of Biochemistry at the Weizmann

Institute of Science, Rehovot, Israel, is seeking applicantsfor a tenure-track position at the Senior Scientist (AS-SISTANT PROFESSOR) level starting in the fall of1995 (earlier start possible). The Department of Bio-chemistry provides an excellent and stimulating researchenvironment with groups conducting research in Molec-ular Genetics (gene expression, DNA replication andrepair) and Bioenergetics (membrane transport systemsand photosynthesis). Candidates are sought in these andother areas of biology, preferably with a background inprotein-DNA interactions, molecular or developmentalGenetics, enzymology, or protein structure and biophys-ical methods. The successful candidate is expected toestablish an independent and creative research group.

Applications should include research plans, curriculumvitae, list of publications and the names of three referees,and should be sent to: Prof. Zvi Livnch, Head, Depart-ment of Biochemistry, Weizmann Insttute of Sci-ence, Rehovot 76100, Israel.

DIRECTOR, CENTER FOR SURGICAL RE-SEARCH-The Department of Surgery, University ofCalifornia, San Francisco is seeking applicants for thenewly endowed Elsbach Richards Chair in SurgicalResearch. Candidate will direct a new 4000 square feetresearch center focusing on basic research relevant totissue injury, including inflammation, angiogenesis andrepair. Candidate must have a Ph.D. and/or M.D. degreeand demonstrated ability to lead an independent researchprogram in an area of cell or molecular biology relevantto injury, inflammation, or repair. Position wfi be at theASSOCIATE PROFESSOR/PROFESSOR level.Send curriculum vitae and three references to: DeanSheppard, M.D., Professor, Department of Medicineand Lung Biology Center, San Francisco GeneralHospital, Bldg. 1, Room 150, 1001 Potrero Ave., SanFrancisco, CA 94110. The University ofCalfornia, SanFrancisco is an Affirmative Action/Equal Opportunity Em-ployer. Women and members of minority groups are encour-aged to apply.

CHAIR, DEPARTMENT OFMOLECULAR BIOLOGY

UNIVERSITY OF TEXAS HEALTH CENTERAT TYLER

Applications and nominations are invited for seniorlevelcandidates that have a substantial research program,active grant support, national/international reputations,and demonstrable administrative skills. The emphasis ofthis young but growing research institute is on researchassociated with heart and lung diseases and all areas ofbasic research in molecular biology related to these areaswill be considered. Tyler is an attractive small city with agood school system amid the forests and lakes of EastTexas about 80 miles east of Dallas. Applications shouldindude a current curriculum vitae, statement of profes-sional goals, description of administrative philosophyand the names, addresses and telephone numbers of fivereferences. Send to: Michael K. Pangburn, Ph.D.,Chairman, Search Committee, University of TexasHealth Center, 11937 U.S. Highway 271, Tyler, TX75708. UTHCT is an Equal Opportunity/4A/irmativeAction Employer. Male/Female/Disabled/Veterans.

SCIENCE * VOL. 265 * 15 JULY 1994430

i0

DEPARTMENT OFGEOLOGY ANDGEOPHYSICSChair of

Geology andGeophysics

Applications and expressions ofinterest are invited for theappointment to the Chair of Geologyand Geophysics. The Department'sparticular interest is explorationgeoscience.The appointee will assume theHeadship of the Department ofGeology and Geophysics for an initialperiod of five years, and will beexpected to provide academicleadership, conduct original research,supervise postgraduate students, andparticipate actively in undergraduateteaching.An opportunity exists to integrate theresources of both the GeophysicalResearch Institute, which has aninternational reputation inexploration and environmentalgeophysics, and the Department, intoan outstanding exploration researchcentre.Staff resources within the Departmentand the Institute includeapproximately 30 academic andprofessional staff. Facilities andequipment include image processing,GIS, X-ray fluorescence, electronmicroscope, thin section andgeochemistry laboratories, and a goodselection of geophysical explorationinstrumentation.Applications from persons withexperience in exploration science(geochemical/geophysical) would beparticularly welcomed.Informal enquiries may be directed toProfessor K. W. Entwistle, Dean of theFaculty of the Sciences, telephone61 67 73 2303, fax 61 67 73 3376.Salary: $78,991 pa (Level E)Closing Date: 31 August, 1994Position No: 518Applications to be addressed to theDirector, Personnel Services,University of New England,Armidale, NSW 2351, Australia,telephone 61 67 73 2678, and shouldinclude the names, addresses,telephone numbers, facsimilenumbers/email addresses of threereferees, and should state the aboveposition number and must bereceived prior to the above closingdate.The right to fill the Chair byinvitation, or to make noappointment, is reserved.

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Hybridon, Inc., is a visionary biotechnology company developing a new genera-

tion ofdrugs that target specific human diseases. As we continue to advance our

science, we're building a strong and exciting business. Join us.

MANAGER OF DATA MANAGEMENTDirecting Drug Development's data management and entry staff, you willmonitor the quality of internal and external data management. Successfulcandidate will assist in software selection and in the implementation of a

computerized system. To succeedyou'll need an BS degree in Biology or

health related field, 3+ years of pharmaceutical or clinical trials experienceand one or more years of experience in a management role including SOPformulation and staff training. Candidate must have knowledge of datamanagement computer software and GCPs, and will be well versed incoding dictionaries for adverse events/medications. DEPT. DM.

MANAGER OF INFORMATION SYSTEMSIdentifying and assessing computer products for the US and European DrugDevelopment Group, you will coordinate database and programming hard-ware/software needs. The successful candidate will assist in systemsimplementation, provide user education and training and interact with otherfunctional groups to assist with systems integration. To qualify, you musthave an MSCS, or equivalent, and 3 or more years of experience in systemsadministration and applications programming development. A solidknowledge of SAS, relational database design and data storage technologyessential. 3 years of pharmaceutical experience is required. DEPI. IS.

ANALYTICAL CHEMISTSExperience which includes Bioassay, NMR, Mass Spectrometry and FITR.Candidates who have experience in Regulatory Affairs would be desirable.Successful candidates should possess an MS with 3 to 5 years'experience or PhD with 2 to 4 years' experience. DEPT. AC.

ANALYTICAL MOLECULAR BIOLOGISTExperience which includes organic synthesis, spectroscopy, HPLC, CE, gelelectrophoresis is required and experience in DNA manipulation is a plus.Successful candidates should possess an MS in a scientific discipline with 3to 5 years' experience. DEPT. MB.

RESEARCH ASSOCIATESExperience which includes oligonucleotide synthesis and/or the chemistryand physical chemistry of oligonucleotide and RNA for studies to developantisense and ribozyme therapeutics. To qualify, you must have a BS/MS inChemistry, or equivalent, and 3 or more years of experience. DEPT. RRA.

Experience in preparative organic chemistry. Familiarity with all currentanalytical techniques including chromatography such as HPLC andUV/NMR spectroscopy are being expected. Knowledge in oligonucleotidesynthesis would be desirable. To qualify you must have 3 or more years ofexperience and a BS/MS in Chemistry or equivalent. The successful candi-date will be part of a new team being organized in our Process Develop-ment Group. DEPT. KPD.

Experience in Molecular Biology and/or Virology. Experience in molecularcloning, mammalian DNA transfections, cell culture and/or animal studiesis appropriate. To qualify, you must have 2 or more years of experience anda BS/MS in Biology or equivalent. DEPI. RES.

With a commitment to steady growth, we offer ongoing professionaldevelopment opportunities. We also provide a highly competitive salaryand benefits package. Please send your resume, referencing thedepartment, to: Human Resources Manager, Hybridon, One InnovationDrive, Worcester, MA 01605. An equal opportunity employer.

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POSITIONS OPEN

IMMUNOLOGISTThe Department of Zoology (reorganizing as the

Department of Cellular Biology) at the University ofGeorgia seeks to fill a tenure-track ASSISTANT PRO-FESSOR position in Cellular or Molecular Immunolo-gy. Applicants with research interests in areas of immu-nology which are central to cellular biology, includingcell activation, cell-cell interactions, signal transductionand membrane trafficking are of particular interest. Theincumbent will be expected to develop a strong, indepen-dent research program and to contibute to undergrad-uate and graduate level teaching. Applicants should sendcurriculum vitae, statements of proposed research andteaching interests, and at least four letters of recommen-dation to: Dr. Rick Tarleton, Chair of ImmunologySearch Committee, Deprtment of Zoology, TheUnversi of Georga, A , GA 30602. Applica-tions received by September 20, 1994, are assured ofconsideration. The University of Georgia is an EqualEmployment/Affirmative Action Institution.

STAFF ASSOCIATE needed by Stroke Center atColumbia-Presbyterian Medical Center to assist in NIH-funded research project. Background in computer scienceand data management required. Responsibilities includecomputer programming; statistical analysis; and reportpreparation. Inquiries with curriculum vitae to: Dr. J. P.Mohr, Director, Stroke Center, The NeurologicalInstitute, 710 West 168th St, New York, NY 10032.Columbia University is an Equal Opportunity/AffinnativeAction Employer.

POSTDOCTORAL FELLOWSHIPIrvine Research Unit in Brain Aging, andHealth Sciences Research Imagin Center

University of California, IrvineThe University ofCalifornia, Irvine (UCI) NIA Train-

ing Program in Aging has a position for a PostdoctoralFellow interested In in-vivo NMR spectroscopy. Appli-cants should have a strong background in biochemistrywith specific experience in NMR spectroscopy. A generalknowledgeofdlinical aspects of aging and dementiawould be helpful. Facilities include a ialized 1.5 Teslaclinical scanner with multinudear IMR spectroscopycapability and a 5.25 Tesla whole body scanner to boperational during the summer of 1995 for in-vivo andin-vitro studies. Research examinin basic and appliedissues in aging and dementia involves interaction with anactive mu ti disciplinary group with applications in Neu-roscience, Radio[ogical Sciences, Computer Assisted Im-age Analysis, Artificial Intelligence, and Molecular Biol-ogy. The appointment will start on January 1, 1995, andthe funding is available for only U.S. citizens and per-manent residents. If you are interested, please submitcurrent curriculum vitae, a statement ofresearch interestsand experience, and the names and addresses of threereferees by October 1, 1994, to: Professor 0. Nalcio-glu, Research Imang Center, College of Medicine,University of California, Irvine, CA 92717-5020.UCI is an Equal Opportunity/Affirmative Action Employercommitted to excellence through diversity.POSTDOCT`ORAL POSITION. To study seasonal

clanges in mRNA and protein abundance of ovariansteroidogenic enzymes in catfish, and isolate cDNAsencoding these enzymes. Ph.D. in a biological scienceand experience with molecular biology techniques re-quired. Experience in steroid reproductive endocrinolo-gy desirable. Start September 1, 1994, (pending finalapproval). Send curriculum vitae and three letters ofreference to: Dr. John Trant, Zoology & Physiology,Louisiana State University, Baton Rouge, LA 70803.An Equal Opportunity Employer.

POSTDOCTORAL POSITIONSSTEROID EFFECTS IN BREAST CANCERAvailable immediately. Project to investigate the role

of adrenal androgens in human breast cancer cell growthand to develop models for studying the regulation ofhuman adrenal androgen synthesis. Previous experiencewith immunodeficient rodents and/or transplantationbiology would be higly desirable. Salary negotiable,dependent on experience. Please send curriculum vitae to:Peter Honsby, Ph.D., Huffno Center on AgnBaylor Colege ofMedicne, One Baylor Plaza - 325,HoustonTh77030. Teephone: (713) 798-7334. FAX:(713) 798-6688. Email poby@bcm.m

Baylor College of Medicine is an Equal Opportunity!AJinrmative Action/Equal Access Employer.

POSITIONS OPEN

POSTDOCTORAL POSITION available now inthe Department of Biochemistry, University of Califor-nia. Experience with molecular biological techniques isrequired. The research involves the heterologous expres-sion of carnitine octanoyltransferase and its site-specifi-cally altered forms. Some experience with protein char-acterization would be useful. Send resume and tworeferences to: Dr. R R. Ramsay, Department ofVeterans Affairs Medical Center, Molecular BiologyDivision (151-S), 4150 Clement Street, San Fran-cisco, CA 94121. FAX: (415) 387-1431.

POSTDOCTORAL POSITIONSMolecular biologists, biochemists and organic chem-

ists are invited to apply for postdoctoral positions involv-ing interdisciplinary research on biomolecular materialsin conjunction with the U.S. Army Natick, RD & ECenter. Projects include the protein engineering of pore-forming proteins, arachnid silks, the insect elastomerresiin and proteinaceous components of molluscan shell[e.g. Nature 349,596 (1991); Sience 262, 1646 (1993);Protein Eng. 7, 91 (1994); 7, 655 (1994); J. Biol.Chem. 268, 5285 (1993); 269, 6661 (1994)].

Call Hagan Bayley at: (508) 842-9146 for details orsend your curriculum vitae and the names of referencesto: Hagan Bayley, cdo Human Resources, WorcesterFoundation, 222 Maple Avenue, Shrewsbury, MA01545. FAX: (508) 842-9632.An Affirmative Action/Equal Opportunity Employer.POSTDOCTORAL POSITION IN NEUROIM-

MUNOLOGY AT BROWN UNIVERSITY. Posi-tion available for individual interested in neuroendocrineregulation ofimmune responses to viral infections. Focusis on role of endogenous steroids in shaping lymphocyteand cytokine responses. Studies are part of multi-centercollaborative projects evaluating health outcomes ofstress. Candidates should have Ph.D. and experience inimmunology, biochemistry, or neuroendocrinology.Send curriculum vitae, statement of research interests,and 3 references to: Dr. Christine A. Biron, BoxG-B618, BioMed, Brown University, Providence, RI02912. Applicants must be U.S. citizens or permanentresidents to qualify for training support in Environmen-tal Pathology from NIEHS. Applications are expectedby August 1, 1994. Screening will begin on that dateand continue until a successful candidate has beenidentified or the search is closed. Brown University is anEqual Opportunity/Affirmative Action Employer.

POSTDOCTORAL POSITIONAvailable immediately to study relationship between

diet and regulation of appetite in animals and humans.Background in nutritionafbiochemistry is desirable. ThisUSDA-sponsored position is open only to U.S. citizensor permanent residents. Please send curriculum vitae andthe names of 3 references to: Dr. Preston Mercer,University of Kentucky, Department of Nutritionand Food Science, 219 Funhose Buildin Lieton, KY 40506-0054, FAX: 606-257-3207, Tele-phone: 606-257-3800. Equal Opportunity Employer.The George Washington University Medical Center

(GWUMC) is seeking a PROFESSOR AND CHAIRfor the Department of Microbiology and Immunology.The GWWC seeks a distinguished Ph.D. or M.D./Ph.D. scientist with an outstanding record of scientificproductivity and proven ability to attract external fund-ng in molecular virology with an emphasis on AIDS andCancer. The Chair will direct the expansion and integra-tion of a program in molecular virology, microbiologyand immunology. The Chair will serve as director of theinterdisciplinary Research Center in Molecular Virologyand actively recruit additional faculty members. Thecandidate should be capable of leading the Departmentto a position of academic excellence and national prom-inence. The successful candidate will have demonstratedexcellence in teaching at the medical, graduate, andpostdoctoral levels, as well as leadership qualities andadministrative skills necessary to develop an academicinterdisciplinary program. Selection process will begin inSeptember 1994 and continue until a successful candi-date is identified. The GWUMC is an Equal Opportunity!AJirmative Action Employer. Applicationsfrom women andminorities are encouraged.

Applicants should submit curriculum vitae, an outlineof current and future research interests, and names ofthree references to: Dr. Christie A. Holland, Centerfor Virology, Immunology and Infectious DiseaseReseach, Children's National Medical Center, 111Michigan Avenue, N.W., Washington, DC 20010.

POSITIONS OPEN

FACULTY POSITION IN NEPHROLOGYThe Division of Nephrology, Department ofMedicine

at the University of Alabama at Birmingham seeks appli-cants for a tenure earning position at the level of AS-SISTANT PROFESSOR Applicants must have a rele-vant Ph.D. or M.D. degree and at least 3 years ofpostdoctoral experience with demonstrated success in ub-lications and securing extramural fuinding. Responsibitieswould include expression cloning of the epithelial sodiumchannel subunits, with special emphasis on human hyper-tensive diseases such as Liddle's syndrome and low-reninhypertension. Special consideration will be given to thosewith strong independent research interests.

Send curriculum vitae to: D. G. Warnock, MD.,Director, Division of Nephrology, University of Ala-bama at Birmingham, Birmingham, AL 35294. FAX:205-934-1879. UAB is an Equal Opportunity/Affirma-tive Action Employer.

POSTDOCTORAL POSITIONBOSTON UNIVERSITY MEDICAL CENTERA postdoctoral position is available to study the rela-

tionship between the structure and function of secretedIgM and its contribution to disease (see PNAS 89:962,'92;JBC 267:18002, '92; Immunol. Today 15; 165, '94;JBC 269:17338, '94). Candidates should have experi-ence in biochemistry and cell biology. Please submit acurriculum vitae summary ofexperience, and three lettersof reference to:

Ronald B. Corley, Ph.D.Department of Microbiology

Boston University School of Medicine80 East Concord St.

Boston, MA 02118-2394.An Equal Opportunity/Affirmative Action Employer.

MOLECULAR BIOLOGISTPOSTDOCTORAL/RESEARCH ASSOCIATE:

position available, September 1, 1994, to explore theregulation of skeletal muscle genes using chimeric genesand in vivo expression systems. Background in molecularbiology and Ph.D. or equivalent required. Salary,$30,000 plus fringe benefits. Send curriculum vitae andthree letters of reference to: Norman Brigs, Ph.D.,Department of Physiology, Box 98055-1, MedicalCollege of Virginia ond, VA 23298-0551.Virginia Commonwealth University is an AflirmativeActionand Equal Opportunity Employer

SYSTEMATIC ZOOLOGISTThe Field Museum is seeking an outstanding system-

atic zoologist to fill a career-track appointment in theDepartment of Zoology at the level of Assistant Curator.Candidates pursu innovative, specimen-based re-search in systematicbology will be considered. Amongthe areas of interest are the following: (a) molecularsystematics, with a focus on integrating population ge-netics and/or molecular mechanisms with systematics;(b) developmental biology, including the use of tissueculture an histology as a means of addressing develop-mental and phylogenetic questions; (c) phylogeneticresearch that investigates questions in population orcommunity ecology; or (d) systematics based on multipledata sets (molecular, morphological, behavioral) or mak-ing important contributions in a second field such asconservation, theoretical systematics, or biogeography.The successful candidate will have a Ph.D. and a provenrecord of scientific achievement. In addition to research,responsibilities include curation ofcollections and partic-ipation in public exhibit and education programs. Thepotential exists for participation in public exhibit andeducation programs. The potential exists for participa-tion in graduate and undergraduate training at localuniversities. The Zoology Department is part of theMuseum's Center for Evolutionary and EnvironmentalBiology which includes the Departments of Botany andGeology. Consideration of applications will begm onSeptember 15, 1994, and will continue until a suitablecandidate is found. Please send the following materials:(1) curriculum vitae; (2) a statement of research objec-tives; (3) names and addresses of 3 people from whomletters of recommendation may be sought; (4) copies ofrelevant publications to: Search Committee, Depart-ment of Zoology, Field Museum, Roosevelt Road atLakeshore Drive, Chicago, IL 60605-2496. Emailinqures: westneat@fmnh.org. As an Equal Opportuni-ty/Affirmative Action Institution, we especially encourageapplicationsfrom women and minorities and we are responsiveto dual-career needs.

SCIENCE * VOL. 265 * 15 JULY 1994432

REGIONAL MEDICAL

ASSOCIATE

SmithKline Beecham is a $9.2 billion global pharma-ceutical and healthcare company. Our world.......ous. . ................... ........~~~~~~~~~~~~~............ ............. ......products and reputation mean-upes ......r.....'..'' t 'ni-ties for individuals to co mt.n ine ..r.....nifi Mn .....r.ket.

ma exoertise as Medical Associates... .................

.We offer one best corpns. tion packages-.....

c...ar ..n *theIf you'd like to be a part

o. our.u. ess,sen.d your resume with salary history to:S''ithKin"'e Beecham, Central Employment, 200-S North16th Street, Philadelphia, PA 19101. We are an EqualOpportunity Employer, M/F/DN.

SBOSmithKI~ne Beecham

DLOGY'n-cer& Infectous Disease Unit, Upjohn

.....abotori xscovery Research, is seeking a highly

.m'otivat.'rsearch associate to join a team dedicated..to th eoveryof novel anti-cancer therapeutic..n..s. The research program emphasizes innovativeapiromac~hes to drug discovery utilizing cellular andmdlecular biology.

Qualified candidates must have a B.S. or M.S. degreeand two years of documented achievement in cellularand molecular biology, biochemistry, or related disci-pline. Preferred applicants will have a working knowl-edge of cell cycle control and regulation of the neo-plastic phenotype and be able to work independentlyin a competitive, but supportive environment.

In addition to an excellent salary and benefits pack-age, Upjohn Laboratories offers a stimulating, multi-disciplinary research environment at our modernfacilities located in Kalamazoo1 a southwesternMichigan community locatd midway between

Detroit and Chicago. Thisregion provides an out-standing mix of cultural and recreational pursuits andreasonable market. For confidential

.. ...................1

consider#V!fl please send-your resume to: TheUpjohn .Caotrporte Recruiting, Ad #217,7000 portage Kamazoo, Michigan 49001.

porunlity Employer with a

orkplae Xdiversity.

I_ Advancing Science...Enhancing Life

Bio-Rad Laboratories is a multinational leader and innova-tor in the development and manufacture of high qualityproducts; chemicals and instruments, for life scienceresearchers and clinical diagnostic professionals.

The Clinical Diagnostics Group is looking for a MarketingManager DNA Diagnostics. We seek a person to identifyand champion technologies and/or products that will lead

to commercial successes. You will work with the entire

Diagnostic Group as well as with our Life Science Group.An advanced degree in molecular biology coupled with

marketing experience and an understanding of both life

science technologies and the diagnostics market, com-

bined with the energy to put it all together would be ideal.

We are looking for a truly excellent person to join our

team. The task will be challenging, exciting and presentreal growth opportunities. If you feel that you are readyfor this challenge, please send your resume, includingsalary history to: Bio-Rad Laboratories, Dept. 325, 4000

Alfred Nobel Dr., Hercules, CA 94547. EOE MFDV.

Bio-Rad Laboratories

CHIEF, CLINICAL PHARMACOLOGY BRANCHNATIONAL CANCER INSTITUTE

The Clinical Oncology Program, National Cancer Insti-tute (NCI), National Institutes of Health (NIH), PublicHealth Service, is seeking applications for the position ofChief, Clinical Pharmacology Branch, at the ClinicalCenter in Bethesda, Maryland. The Branch is an inte-grated clinical and laboratory program in cancer medi-cine. The laboratories, consisting of 5000 square feet ofspace, support four senior research investigators. Inaddition, the Branch has access to NCI's inpatient wardsand outpatient clinics at the NIH Clinical Center fortranslation clinical research in cancer medicine. ThisBranch has been a leader in the development of newagents and new approaches for cancer treatment. TheClinical Pharmacology Branch is also an integral part ofthe NCI training programs in both medical and radiationoncology.We are seeking a senior clinical scientist who is at theforefront of research in the molecular and cellular biolo-gy of cancer. U.S. citizenship is required. Salary range is$71,049-$91,029. Payment of travel and transportationexpenses will be considered on an individual basis.Exceptional recruiting difficulty may result in payment ofa recruitment or relocation bonus. Application for Feder-al Employment (SF-1 71) must be received or post-marked by August 29, 1994. For application information,please contact Patrick Miller, Personnel ManagementSpecialist, NCI, on (301) 496-1771.NIH is an Equal Opportunity Employer.

0

P-00 1 0, 1

POSITIONS OPEN

POSTDOCTORAL position available immediatelyto study gene expression from recombinant La Crosse-Sindbis viruses utilizing molecular biological and viro-logical techniques. Strong experience in biochemistry ormolecular biology or tissue culture essential. Please con-tact: Dr. Rain Ramm, Microbiolog, MeharryMedical College, Nashvill, TN 37208. Telephone:615-327-6687, FAX: 615-327-6072. Candidates mayalso send their curriculum vitae and two letters ofrecommendation to the above address.

POSTDOCTORAL POSITION, MOLECULARGENETICS OF COLOR VISION. An immediateposition is available to conduct molecular analyses, in-duding characterization and structure/finction relation-ships, of opsin genes in vertebrates. Experience withmolecular methodology (restriction mapping, screeningof genomic libraries, dloning and sequencing) is re-quired. A strong interest in molecular evolution is desir-able. Send curriculum vitae, a statement of researchinterests, and three references to: Dr. Shozo Yokoyama,Dqnrtment of Biology, 130 College Place, Syracuse,

Telphone: 315-443-9166; FAX: 315-443-2012; Ema: SYOKOYAM@SUVM.BITNET.Affirmative Action/Equal Opportunity Employer.

POSTDOCTORAL POSITIONSLymphocyte Development

Applications are invited for postdoctoral positions tostudy molecular events in haematopoietic stem cell andlymphocyte development. Please send curriculum vitae,statement of research interests and three letters of refer-ences to: Dr. Ronald Palacios, Deprtment of Immu-nology, Box 178, U.T. M.D Anderson Cancer Cen-ter, 1515 Holcombe Boulevard, Houston, TX 77030.An Equal Opportunity/Affirmative Action Employer.Smoke-free environment.

FOUR POSTGRADUATE RESEARCH AP-POINTMENTS sponsored by EPA's EnvironemntalMonitoring Systems Laboratory (EMSL) in Cincinnati,OH. (1) Molecular Biologist (EMSL 94-2); researchinvolves using molecular methods to analyze Populationgenetic diversity in wildlife. M.S. or higher degree withexperience in molecular genetics required. (2/3) Terres-tral Ecologist (EMSL 94-1/10)-two postdoctoral po-sitions to assist with research on improved methods toassess stressor-induced risks to terrestrial wildlife andlorsoil biota; and to evaluate ecological risks associated withthe land application of sewage sludge, (4) Plant Popu-lation Geneticist (EMSL 94-3); research, tenable at theUniversity of Cincinnati, Department of Biological Sci-ence, involves investigations, using VNTR DNA varia-tion, of effects of anthropogenic disturbance on popula-tion genetics of selected plants species. Ph.D. withexperience in plant molecular population genetics pre-ferred. Participants receive monthly stipends. Contact:Postgraduate Research Programs/EMSL, Science En-gineering Division, Oak Ridge Institute for Scienceand Education, P.O. Box 117, Oak Ridge, TN37831-0117, (615) 576-3456.

PROTEOGLYCANS IN ALZHEIMER'SDISEASE

One POSIDOCTORAL POSITION available (Sep-tember 1, 1994) in the laboory of Dr. Alan Snow in theDepartment of Pathology at the UniversityofWaslifgtonin Seattle. Research in Dr. Snow's lab focuses on the role ofprotglyns in the p of anyloidosis in Alxhe-irners disease (AD). with expeience in moecu-lar biology (Nortms, Southerns, cloning, PCR etc.), in-situ hybridizion and production of transgenic animals areprekrentallyseeked. Money for a 3-year postdoc frI-

availabl. Applicants send curriculum vitae andnce list to: Dr. Alan Snow, Uniesiy ofW

soDeatmn of Patolg, Neuoathlg LabsRJ-05, S~eatte, WA 98195. Prefprential candidates will beinvited to Seattle to interview.

POSTDOCTORAL POSITION IN PLANTPHYSIOLOGY available in September 1994 to studythe cytoplasmic regulation of iron(m) reductase activityin roots. Research involves the isolation of a phloem-mobile signal compound which enhances root reductaseactivity. Recent Ph.D. in plant physiology, biochemistry,cell biology, or related field required; experience inimmobilized metal affinity chromatography would behelpful. Send curriculum vitae and names of three refer-ences to: Dr. Michael A. Grusak, USDA-ARS,CNRC, 1100 Bates Street, Houston, TX 77030.

POSITIONS OPEN

Virginia Commonwealth University's (VCU) Depart-ment of Pharmacology and Toxicology seeks a POST-DOCTORAL FELLOW to study opioid tolerance anddependence in neonatal rats. The project involves behav-ioral pharmacology and molecular biology, including insitu hybridization and PCR. Recent Ph.D.s with a back-ground in pharmacology or neuroscience are encouragedto apply. Send curriculum vitae and names of threereferences to: Dr. Mary Abood, Pharmacology andToxicology, MCV/VCU Box 980524, Richmond,VA 23298-0524. Anticipated hire in fall 1994.

POSTDOCTORAL FELLOWSHIP IN AR-THRlTIS GENE THERAPY. We are seeking a well-trained, motivated molecular biologist to join a team ofresearchers who are conducting pre-clinical arthritis genetherapy studies at a leading arthritis research center. Thecandidate would be involved in studies to test thefeasibility of using gene transfer techniques to modifymechanisms underlying arthritis. Experience with trans-fections, Northerns, dot blots, RT-PCR, CAT assays,vector construction and packaging, molecular doningand plasmid purification is desired. Position requires a

Ph.D. degree. FAX or send curriculum vitae and twoletters of recommendation to: William J. Koopman,M.D., Howard L. Holley, Professor of Medicine,

Director, Division of Clinical Immunology andRheumatology, The University of Alabama at Bir-mingham, Birmingham, AL 35294. FAX: (205) 934-1564. Position available July 1, 1994. UAB is an Affir-mative Action/Equal Opportunity Employer.

POSTDOCTORAL FE LLOW/RESEARCH ASSO-CIATE. Two positions are available to study: a) the molec-ular mechanisms and control ofHlV-1 replication inT cells,particularly as regards to the role of the vdf gene; b) themolecular basis for HIV-1 neurotropism and HIV-1 medi-ated encephalopathy in AIDS. Aicants should have aPhD. orequivalentand3to5 years ofexperienceinrvirologyand molecular biology. Salary: $25,000 to $30,000. Direct

s, including curriculum vitae and names of threeto: Dr. David J. Volsky, Molecular Virolgy

Laboraty St Lukes/Rooseelt Hospital Center andCollege of Physidan and Surgeons, Colmbia Unmver-siy, 432 West 58th Street, New York, NY 10019,Telephone: (212) 582-4451, FAX: (212) 582-5027.AnEqual Opporunity/Aimiative Action Employer.

RESEARCH PROGRAM on cellular and molecularaspects of antioxidants' function in skin. The study focuseson molecular mechanisms involved in the cellular responseto environmental and oxidative stresses. Requirements:Ph.D. with minimum 3 years of experience m areas ofbiological chemistry/cell biology, expertise in a broad rangeofmolecular techniques, inchlding protein biochemistry andenzymology. Please submit application, curriculum vitae andthree prossional rekrences to: Linus Pauling Instute of

440 Page Mill Road, Palo

CA 94306 (Atm: Dr. Niediecki).POSTDOCTORAL POSITION available immedi-

ately to study chemistry and biology of DNA damageproduced by enediyne anticancer drugs. Qualifications:Ph.D. in chemistry or biology with significant experiencein nucleic acid biochemistry and/or molecular/cell biolo-gy ofDNA damage. Send curriculum vitae, summary ofresearch experience, and names/addresses of three refer-ences to: Dr. Peter Dedon, Division of Toxicology,16-336B, MIT, Cambridge, MA 02139. Equal Oppor-tunity/Afllrmative Action Employer.

POSITIONS OPEN

RESEARCH SCIENTISTPosition is immediately available to study HIV-1 and

B cell lymphokine expression at the cellular and molecu-lar levels. Specific requirements include strong back-ground in molecular biology and cellular immunology ofHIV-1. Excellent salary and fringe benefits. Send resume,names and addresses of three references and salary re-quirements to: David Benjamin, M.D., 1232 JamesCancer Hospital and Research Institute, The OhioState University Hospitals, 300 W. 10th Avenue,Columbus, OH 43210-1228. Telephone: (614) 293-3716; FAX: (614) 293-4372.

RESEARCHERS...ACCEPT THE CHALLENGE OF TOMORROW!

As a dedicated pioneer of health products, OtsukaAmerica Pharmaceutical, Inc. is a company led by aguiding principal of providing better health throughpharmaceutical innovation. We could be your new ave-

nue to expanding and refining your research talents.We are currently seeking RESEARCHERS (M.S.

degree/Ph.D. preferred) with experience in:* The physico-chemical analysis of drug action in pro-

tein binding (a background in either protein chemistryor physical chemistry is acceptable).

* Signal transduction analysis of drug action (a back-ground in cell biology, molecular biology, immunol-ogy, or microbiology is acceptable).

* Animal model analysis of drug effect (background inveterinarian medicine, pathology, pharmacology, or

animal biology is acceptable).Otsuka America Pharmaceutical, Inc. offers a compet-

itive salary and an attractive benefits plan which includes:company paid health insurance, dependent care flexiblespending account, 401(k) plan and a fully paid retire-ment program. To apply send your resume and salaryrequirements to: Helena Matos, Human ResourcesDept. 1000, Otsuka America Pharmaceutical, Inc.,2440 Research Blvd., 5th Floor, Rockville, MD20850. An Equal Opportunity Employer.OTSUKA AMERICA PHARMACEUTICAL, INC.

HOTEL-DIEU HOSPITAL RESEARCHCENTER/BURN CENTER

AFFILIATED WITH THE UNIVERSITY OFMONTREAL

The Research Group on Burn injuries in Hotel-DieuHospital, Montreal, Canada, and the Clinical ResearchCenter ofHotel-Dieu are seeking an INVESTIGATORwith a Ph.D. in immunology to pursue clinical and/orfundamental research on the immune system duringinjury and trauma. Send curriculum vitae, names andaddresses of three references, and a statement about yourresearch orientations to: D. R. Garrel, M.D., ClinicalResearch Center, Hotel-Dieu Hospital of Montreal,3850 St. Urbain Street, Montreal, Quebec, Canada,H2W 1T8.

POSTDOCTORAL RESEARCH SCIENTIST.Position available to work in clinical laboratory studyinghuman motor physiology and the quantitative assessmentof movement disorders. Applicant must have Ph.D. inbiomedical engineering or equivalent, expertise with dataacquisition electronics and programmng abilities. Expe-rience in expert systems and digital imaging technology is

preferred. Send curriculum vitae and three letters ofreference to: Dr. Seth Pullman, Director, ClinicalMotor Physiology Laboratory, The Neurological In-stitute, Columbia-Presbyteran Medical Center, 710W. 168th Street, New York, NY 10032. CU is an

Equal Opportunity/Affirnative Action Employer.

SENIOR PROGRAMMER/RESEARCHER: De-velop federated multidatabase management systems fordistrbuted, heterogeneous environments utilizing com-putational models from relational, object-oriented anddeductive DBM's. Plan, direct and coordinate researchactivities of multidatabase management systems to devel-op new and improved systems and programs. Planresearch programs and direct experiments to improvenew systems and explore possibilities of new theories,(e.g. artificial intelligence). Must have in-depth knowl-edge of VMS, UNIX, OS2, Objective-C, C+ +,SMALLTALK, CLOS, VAX, NeXT, SUN. Must havePh.D. in computer science or M.S. with at least 10 years

experience. Salary: $50,000 per year. Job Site/Interview:Anaheim, CA. Send this ad and your resume to: Job#CL409299, P.O. Box 269065, Sacramento, CA95826-9065 no later than August 1, 1994.

SCIENCE * VOL. 265 * 15 JULY 1994

HARVARD MEDICAL SCHOOLJOSLIN DIABETES CENTERPOSTDOCTORAL POSITIONS

Two positions available immediately to studythe immunological defects underlying the devel-opment of type I diabetes in a laboratory wherestate-of-the-art transgenic mouse and gene target-ing techniques are used. Current projects focuson the mechanisms of antigen-specific toleranceinduction and the nature of immune recognition(Science 259:1165, 1993) in NOD mice. Candi-dates should have a strong background in molec-ular biology and immunology. Please send cur-riculum vitae, a summary of research interests,and the names and addresses of three referencesto: Dr. Myra A. Upes, Research Division,Joslin Diabetes Center, One Joslin Place, Bos-ton, MA 02215.

434

CARDIOVASCULARPHARMACOLOGIST

SmithKline Beecham Pharmaceuticals has an interna-tional reputation for taking an innovative approach todrug discovery and development. Our success .s built onthe collaboration of multidisciplinary tswho share ideas and expertise tfacilities on projects th

Currently, iatecar hao isina r

vecom and r con-_nsi ase urresume and

nces to: SmithKline Beechamloyment Administrator, #H0210, PO

ohocken, PA 19428. We are an Equaliity Employer, M/FIDN.

SmithKIine BeechamPharmaceuticals

Challenging the natural limits.

A research assistant position is available to investigateand develop new types of recombinant immunotoxinsdirected at cancer cells. The position requires broadexpertise in molecular biology, protein purification, andin the design of recombinant immunotoxins containingPseudomonas toxin and Fv fragments of antibodies. Theposition also requires expertise in phage antibody dis-play, knowledge of properties of cancer cells and theirbiochemical responses to toxin treatment. Applicantmust have a Doctoral level degree and at least fouryears post doctoral experience. Salary ranges between$40,000 to $50,000, depending on experience. Selec-tion for this position will be based solely on merit, with nodiscrimination for non-merit reasons such as race, color,religion, gender, national origin, politics, marital status,physical or mental disability, age, sexual orientation ormembership or non-membership in an employee orga-nization.

To apply, please send curriculum vitae, reprints, descrip-tion of research experience and a list of references to:

Dr. Ira PastanChief, Laboratory of Molecular BiologyDHS, PHS, NIH, National Cancer InstituteBuilding 37, Room 48-16Bethesda, MD 20892

Applications must be received by August 12, 1994NIH/NCI is an Equal Opportunity Employer

PENN STATEFACULTY POSITIONS IN

BIOLOGYThe Department of Biology is build-ing an interdisciplinary program inplant sciences and invites applica-tions for two tenure track ASSIS-TANT PROFESSORS beginningas early as January, 1995. Weseek candidates with a commit-ment to excellence in teaching andresearch as well as an extensivemolecular background, experienceand excellence in sequencing, amajor interest in gene regulatorymechanisms unique to plants,postdoctoral experience, and evi-dence of potential to develop anindependent, vigorous, externallyfunded research program. Sendletter of application, includingstatement of research and teach-ing interests, curriculum vitae, andnames, addresses, and phonenumbers of three references to:Unda Maxson, Box PS, Depart-ment of Biology, 208 MuellerLab, Penn State University, PA16802-5301. Evaluations will be-gin in August and will continue untilpositions are filled. An AffirmativeAction/Equal Opportunity Employ-er. Women and Minorities encour-aged to apply.

The hihevsy of Westem Mala

Perth

CHAIR IN PSYCHIATRY FOR THE ELDERLYApplications are invited for this newly established Chair in Psychiatry for the Elderly frommedical graduates registered or eligible for registration in Western Australia. In addition toappropriate professional qualifications, it is essential that applicants meet the accreditationrequirements for Fellowship of the Royal Australian and New Zealand College of Psychiatrists orits equivalent.The academic and administrative location of the Chair is in the University Department ofPsychiatry and Behavioural Science, attached to the Sir Charles Gairdner Hospital - an adultteaching hospital.The appointee is expected to contribute to undergraduate and postgraduate teaching, and totake a prominent leadership role in future psychogeriatric research, psychiatric clinical servicesand policy development in Western Australia.The appointment is for five years, (subject to annual review for the first three years). Anattractive remuneration package will be negotiated. Benefits include generous superannuation,study leave with travel assistance after three years, long service leave, fares to Perth for theappointee and dependents and an allowance towards removal expenses.Intending applicants must obtain a selection package which includes the selection criteria andinformation about the position and conditions of employment, from Professor AJablensky in theDepartment of Psychiatry and Behavioural Science, tel. [61 9] 389 2394; facsimile [61 9] 3893828.Applications, addressing the selection criteria, and stating full personal particulars (includingwork and home addresses, telephone and facsimile numbers), should reach the Director, HumanResources, The University of Western Australia, Nedlands, (Perth) Western Australia 6009 byWednesday, 17 August 1994. The names, addresses and facsimile numbers of three refereesshould also be included with the application.The University reserves the right to make no appointment or to fill the position by invitation.The University is an equal opportunity employer and promotes a smoke-free work environment.Women are encouraged to apply for this position.

-1

National Center for HumanGenome Research

National Institutes of HealthVisiting Investigator Program

The Visiting Investigator Program providesfaculty level scientists from outside the NIHwith the opportunity to spend a 3-12 monthperiod at the National Center for Human Ge-nome Research (NCHGR) laboratories andclinics at the NIH. Visiting investigators canuse their stay at the NCHGR to learn newtechnologies, develop research collaborations,or pursue sabbatical research projects. Basicand clinical genetic researchers and socialscientists may access the Centers laborato-ries, core facilities, clinics, and training pro-grams for study in any area of human geneticdisease, including the social implications ofgenetic research. Partial funding of salarysupport is available, as well as all funding forresearch related expenses while at the NIH.Project proposals extending to one year arepreferred in order to enhance the possibility ofaccomplishing research objectives. Applica-tions may be initiated by submitting: a curricu-lum vitae, a cover letter describing the pro-posed project to study or collaborative effort(including the time frame proposed to com-plete the study), and a supporting letter fromthe candidate's department head (or equiva-lent). Applications are accepted throughoutthe year with the program commencing Janu-ary 1, 1 995. Applications for the cycle begin-ning January 1, 1995 must be received bySeptember 1, 1994.

For Program application informationor questions, contact:

Betty Wolf, DirectorVisiting Investigator Program

NIH/National Center forHuman Genome ResearchBuilding 49, Room 4A289000 Rockvllle Pike

Bethesda, Maryland 20892Tel: (301) 402-2012Fax: (301) 402-2440

e-mail: wolfie@helix.nih.gov

Procte&Gamble

Ph.D. CELL BIOLOGISTThe successful candidate will investigate the role of growthfactors and their receptors in skin and related tissues.

Experience with in situ hybridization and histology is required.Experience with transgenic models is desirable. Applicantsshould have a Ph.D. in cell biology or related discipline and 2-3years of postdoctoral experience.

Procter & GambkeR&PD Technical Recruiting, Dept. CO

P.O. Box 398707 * Cincinnati, OH 45239-8707lI

ANNOUNCEMENT

0(_

POTAMKIN PRIZE FOR RESEARCH INPICK'S, ALZHEIMER'S AND RELATED DISEASES

A prize of $100,000 will be awarded by the American Academy ofNeurology to a person(s) in recognition of major contributions to theunderstanding of the causes and the prevention, treatment, and ultimatelythe cure for Pick's, Alzheimer's and related diseases.

Candidates may be nominated on a world-wide basis from any of thebiological disciplines including biochemistry, molecular biology, moleculargenetics, pharmacology, immunology, physiology, cell biology,neuropathology or epidemiology.A nomination application, nominating letterciting the scientific accomplish-ments of the candidate in detail, two supporting nominating letters, a

curriculum vitae, and up to six (6) selected reprints in nine (9) complete sets

are required.The deadline for receipt of materials is November 1, 1994. No nomination

will be considered unless it is complete. The awardee(s) must be presentfor the MN Scientific Program, at its annual meeting in Seattle, Washing-ton, on Tuesday, May 9, 1995.

Request application and submit nomination to:

Potamkin Prize for Research in Pick's,Alzheimer's and Related DiseasesAmerican Academy of Neurology2221 University Avenue S.E. - Suite 335Minneapolis, MN 55414(612) 623-8115The Potamkin Prize is funded through the philanthropy of the Potamkin

Foundation.

Women and minority candidates are stronglyencouraged to apply.I

.

_i

Since 1888, Abbott has made profound advances in the developmentof health care products and services. Today, the NeuroscienceDiscovery Group of our Pharmaceutical Products Division is con-tinuing this commitment through its innovative work in therapeuticapproaches for the treatment of neurodegenerative diseases.

GROUP LEADERNeuroimmunology

You will head a multi-disciplinary group of PhD and associate sci-entists that will identify and exploit molecular targets involved inthe regulation of neuronal viability as it relates to neurodegenerativediseases.This position requires: a PhD and at least 6-10 years of postdoctoralexperience with expertise in cellular and molecular biology andpharmacology; research experience in immunology and/or neuro-biology; and a demonstrated record of achievement. In addition,management experience and a pharmaceutical or drug discoveryresearch background are desirable.Abbott provides an excellent salary and benefits package includingprofit sharing and a stock retirement plan. We are located in anattractive suburban area, approximately 30 miles north ofChicago. For confidential consideration, please send a resume andsalary history to: Allson Burke, Job# S65531, D-583, AP6B,Abbott Laboratoes, One Abbott Park Rd., Abbott Park, IL 60064Abbott is an Affirmative Action Employer/Smoke-FreeEnvironment.

ABBOlT LAORATORES

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What makes Pfizer a major force in pharmaceuticalproges? The answeris tobe found in real life-in peo-

ple who thrive on developingnew and better

therapeuticanswers to

__________________________ real-lifeneeds.

searchSuch arethe scien-tists ofPfizer's

Central Re-search Division.

Located on theConnecticut shore, our Central

Research Division is a place of state-of-the-art laboratories, invigorating discovery objectives,and significant investment in R&D primarily,though, it's a place of individuals...individualswho work hard to make a difference.

Currently, we have challenging opportunities on akey interdisciplinary discovery group workingwithin the Department of Molecular Genetics andProtein Chemistry. The first position requires thedepth ofexperience needed to play a central role onprojects involving enzyme kinetics and protein purifi-cation/characterization. Detailed knowledge of the useof FPLC and/or HPLC/BIOCAD for analytical/pre-parative purposes is essential. In addition, a posi-tion exists with responsibilities focusing on pro-tein purification and/or protein expression.

Qualified candidates will possess a B.Sc. or M.Sc.in Biology or Biochemistry and experience in thestructure and dynamics of recombinant proteins.A background in recombinant DNA derived pro-tein isolation and purification with a special em-phasis on preparing highly purified samples forstructural analysis is necessary. Use ofFPLC/HPLCwould be an asset.

These openings require strong communication,problem solving and analytical skills. In ex-change for your expertise, Pfizer offers excel-lent compensation, attractive benefits includ-ing a relocation package, and opportunities forsignificant growth. For confidential considera-tion, send your resume to: Ms. Lynn Beaulieu,Employee Resources, Pfizer Inc, CentralResearch Division, Eastern Point Road,Groton, CT 06340.

We are an equal opportunity employer. M/F/D/V

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Research Assistants-ASSAY DEVELOPMENTAND SCREENING GROUP-

Onyx Pharmaceuticals is a dynamic young company engaged inthe development of small molecule therapeutics for cancer and otherdiseases associated with abnormal cell growth. Our research focuseson the ras superfamily, tumor suppressor genes, and the fundamentalmechanisms governing many cell functions induding growth anddifferentiation.Our commitment to establish a world-class screening operation hascreated an excellent opportunity for both M.S. and B.S. level personnelwith significant experience and expertise in mechanism-based highthroughput screening of compounds, natural products and/or combi-natorial chemical libraries. In addition to having demonstrable skillsin assay development, high throughput screening and protein bio-chemistry, candidates must be highly motivated individuals posses-sing good organizational and interpersonal skills.

ONYX is located in the San Francisco Bay Area, not far from Berkeley.A highly interactive atmosphere prevails, where publications and opendiscussions are strongly encouraged. We offer a competitive salaryand benefits package, which includes stock options. If you are inter-ested in joining us, pleases send/FAX your resume, in confidence, to:OnyxPhameals, HR Department, Attn: RC-S, 3031 ResearchDrive, Richmond, CA 94806. FAX: (510) 222-9758. EqualOpportunity Employer

ONYXPHARMACEU TIC AL S

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Announcing the 2ndAnnual

BS/MS Careers Issue

August26, 1994

last year we advertised In the SCIENCE OS/MS Issue. Ourpresence In that Issue really Increased our visibility oncollege capuses.Donna Kleinschmidt, University Relations Manager, Hoffimann-La Roche

Get B.S. and M.S. students excited about you careeropportunities or your graduate programs.SCIENCE Magazine offers you a once a year opportu-nity to reach the best and brightest science studentsand tell them about your career opportunities orgraduate programs in the August 26, 1994 issue.You'll reach over 159,000 regular subscribers as wellas get special bonus distribution to top science stu-dents around the US.

Bonus distribution to the 70 top biology and chemistryprograms In the US.Make sure your message gets the impact you needthrough our regular 159,000 subscriber base athrough the bonus distribution to students in the topbiology and chemistry programs around the US. Fullpage advertisers get bonus distribution to the top 70colleges and universities** in the special reprint of theBS/MS advertising section.

Reach eligible minority students.Do you need to reach a diverse pool of candidates?When you advertise in the BS/MS careers issue youradvertisement will get special distribution to U.S.colleges and universities with historically high minorityenrolment.

The clock Is ticking, so don't delay!Timing means everything when you need to reach topscientists. Advertising in SCIENCE increases yourchance of reaching the best and brightest candidatesfit. Get scientists excited about your company.Advertise in SCIENCE!

Placing your ad Is easy!The SCIENCE recruitment advertising staff makesyour advertising placement easy! Call Janis Crowley at(212) 496-7704, or fax (202) 682-0816 for moreinformation.

SCIENCEListing of colleges and universities participating in the 1994 bonus distribution of the SCIENCE BS/MS reprint:

Alban A&M University'Boston UniversityBraideis UniversityBrighan Young UniversityBrcwn UniversityCaltechCarnegie Mellon UniversityColorado State UniversityColumba UniversityCornell UniversityDartmoiih CollegeDelaware State University'Duke UniversityEmory UniversityFisk University'Florida A & M University'Georgeown UniversityGrambling College'Harvard UniversityHoward University'

Indiana UniversityJohns Hopkins UniversityLehigh UniversityMITMichigan State University'More e College*New Mexico State UniversityNewYork UniversityNortheastern UniversityNorth Carolina A & T State UniversityNorth Carolina Central UniversityOhio Slate UniversityPenn State UniversityPrinceton UniversityPurdue UniversityRice UniversitySpelman College'Stanford UniversitySUNY, BuffaloSyracuse University

Texas Tech UniversityTufts UniversityTuskegee University'University of Arkansas'UC - BerketeyUC - DavisUC - Los AngelesUC - RiversideUC - San DiegoUC - Santa BarbaraUC - Santa Cruz,University d ChicagoUniversity of ColoradoUniversity of DelawareUniversity of HoustonUniversity d IllinoisUniversity of MassachusettsUniversity of MiamiUniversity of MinnesciaUniversity od North Carolina

Unversity of Noire DameUniversity of OregonUniversity ot PennsylvaniaUniversity of PittsburghUniversity of South CarolinaUniversity of Texas at AustinUniversity of UtahUniversity of WashingtonUniversity of WisconsinVanderbilt UniversityWashington UniversityWinston-Salem State University'Yale UniversityYeshiva University

Advertising Space ReservationDeadline: August 9, 1994.

**The Nations top schools for Biological Sciences, various Chemistry disciplines and Clinical Medicine ranked by the Institute for Scientific Information's Science Watch, as well as thetop 20 schools from US. News & World Report'sAnnual AericasBestCollegesissue. *Denotesinsttutonwithhistoncaityhighminortyenrollment-v. -- -- ~-

'I:

-

Affmative ActiasEqual Opportunity Employer.

CreatingNew Technologies For

FOCAL INC. combines proprietary polymer and delivery device technolo-gies to create innovative products that prevent post-surgical adhesions.

thrombosis and restenosis. Our current success and business growth havecreated the need for the following team-oriented, self-motivated

professlonals to join us.

_i hy THis individual will pem surgical pores toevaluate novd theraies forpost-s alesions, renoss ando local disease saes. Dudes include model and prdure develop-

_ mnt, providing pre and pot-opeive cae, deveopig apppia pools and anawng researchreu We require an MS orhigherin the life sciences ormedicin, and5+ years' experience pefornggeneral uricedaues in a research environnent Experience with miro-vasculartec andcatetezn is pmef~en

----

Yon will assist in the development and commercia on ofhydrgel-based products. paticipating in cross-functional teams to provide apble fornu-lations, containers and sterile processes. We require a BS/MS in pisanacy or chemistry, and3-5 yews' hands-on experience in pOmical product development Demronsted work-ing knowledge in the design and formulation of parenteral products and/or delivery systems isessetal, along with expertise in GLP, GMP and sterile process developmnnt.Along withsfrong copeno, benefits and eui pcipton, FOCALdprovides a crmdaive; coopetidve ocusedwoeeronmen welworth yourforwardng a rsme i confidncwe to: Humma Resources,FOCA4 Inc., One Kenil Squre uildin 60 Camge, MA( 02139.Nophone cais, p1 we; FOCAL is equal 4rna actionend~.Fffw .

1S E>ocal It7. .*w ~INTERVENITIONAL THERAPEUTICS

Technology For Life.

Genelabs Technologies, Inc. is a broad-based biopharmaceutical company focused onthe discovery, development and commercialization of products for the diagnosis,treatment and prevention of viral diseases and cancer. We provide an exciting andchallenging environment where you are encouraged to reach your full potential.

The successful candidates will interact with a multidisciplinary team induding immu-nology, cell biology, protein biochemistry and molecular virology expertise. A PhD inVirology, Cell Biology or Immunology and at least three years of relevant post doctoralexperience are a must. Requirements include experience with the specific techniqueslisted in each description, as well as excellent written and verbal communication andpresentation skills.

Virologist/Celi BiologistYou will be responsible for the establishment, validation and application of in vitrosystems for propagation of viral pathogens and evaluation of viral replication, includ-ing both protein and nucleic acid readout systems, using both primary cells andtransformed cell lines. This position will also involve development of techniques forviral antigen detection and viral neutralization assays, with an emphasis on develop-ment of vaccines for hepatotropic viruses.

Viral ImmunologistYou will be responsible for immunological characterization of vaccine candidatesincluding generation and characterization of monoclonal antibodies to viral antigenpreparations (epitope mapping, fine specificity, affinity, and immunobiological proper-ties). This position also involves oversight of small animal immunizations and charac-terization of immunological responses including neutralizing and non-neutralizinghumoral, ADCC and cellular responses (proliferative and cytotoxic) as well as com-parative evaluation of immunological properties of alternative antigen and adjuvantpreparations. Demonstrated expertise in immunoregulation or mucosal immunologyfavorably regarded.

TWO ASSISTANTPROFESSOR POSITIONS

The Department of Entomology at the Univer-sity of Georgia invites applications for twotenure-trackpositionstobeginSeptember, 1995.

INSECTSYSTEMATIST Thesuccessful can-didate will be expected to sustain a major re-search program in Anhropod Systematics andPhylogenetics that emphasizes modem ap-proaches and techniques. Teaching responsi-bilities include graduate-level courses in InsectTaxonomy and Systematics, Insect Morphol-ogy, and an additional course in the candidate'sspecific area of interest.

INSECT PHYSIOLOGIST The successfulcandidate will be expected to develop a strong,creative research program and teach at the un-dergraduate and graduate levels. Those apply-ing molecular approaches to fundamental ento-mological questions are especially encouragedto apply.

Applications received by November 1, 1994areassured of consideration. Applicants should ar-range forfourletters ofreference tobe senttotheappropriate committee. Applyby sending a cur-riculum vitae, list ofpublications, three selectedreprints, brief statements of research and teach-ing interests, and fourletters of reference (solic-ited by the applicant) to:

Insect Systematics Search Conmittee, orInsect Physiologist Search Committee

Department of EntomologyUniversity of Georgia

Athens, GA 30602-2603

The Universiay ofGeorgia is an EqualOpportunitylAffirmative Action Etployer

Desert Research InstituteReno, NV

Ass't Research Professor

Prgam managment of air quality research projects;development and application of gaso osol mea-sumement methods; statistical data analysis; source

cetor modeling and data interpretation on mass andchanicallyspeciated aerosol,gaseous andmeterologi-cal data; prepativeacrosoi, gaseous and meteorologi-cal data; preparation of proposals, reports and jounalarticles; establishing and maintaining relations withsponsors; and presenting researh findings.

Post-Doctoral Research AssistantOne-Year App't.

Assist in developing new air quality research areas andsampling and analysis methods foratmospheric pollut-ants, participate in field mesurement programs, con-

duct microcomputer-based analysis of air quality and

meteorologicaldata andpepajounal articles, reportsand proposals.

Positions require doctorates in environmental science,physics. engeinngor chemistry from accredited uni-

vesities;previousexperencperforningdutiessimilarto those listed above, proficiency in FoxPro, Excel,Harvard and Freelance Graphics and Word 6.0 anddemonstrable written/oral communication and humanrelations skills. Previous publications, successful pro-

posal preparation and prior industrial or technologytransfer experience desirable. Salaries commensuratewith qualifications and experience. Excellent benefitspackage. Submitremone-pagenarrativedescribinghowyourqualificationsmeetpositionrquiments andnames, addresses and phone nunbers of three refer-

inces to: Recruitment Office, Desert Research Insti-tute, UCCN P.O. Box 19040, Las Vegas, NV 89132-0040.

Genelabs Technologies, Inc. has an excellent com-pensation program including our medical and den-tal coverage, stock plans, 401(k), 125(k), tuitionreimbursement, bonus program, and much more.Please send your resume, indicating position ofinterest, to: Genelabs Technologies, Inc., HumanResources, 505 Penobscot Drive, Redwood City,CA 94063, or FAX (415) 368-0709. Equal Opportu- G E N E L A B Snity Employer. T ECH No0LO tEs5. rN C.

a

On 23 September 1994 Science will present its annual Careers issue.Here's your chance to place your advertisement in one of the most important andpopular issues of the year. Last year's Careers issue highlighted over 65 pages ofcareeropportunities for scientists at all levels. The 1994 issue will once again rankas one of the top scientific career planning resources. You can be sure scientistsat all levels will use the Careers issue to survey the job market and plan futurecareer moves.

When you advertise in the 23 September issue you will receive:* Bonus Distribution

Copies of the 23 September issue will be distributed to over 2,000 attendeesat each of the Biotechnology/Phannaceutical Job Fairs in La Jolla, CA on September23-24, and in Cambridge, MA on September 30-October 1.* Advertisers' Index

Full page advertisers will be listed separately on an index affixed to thecovers of the issues distributed at the job fairs.* Harvey Readership Study

Full page advertisers will benefit from a Harvey Readership Study a terrificway to find out what Science readers are thinking about your advertising message.

Advertising Deadline: 6 September 1994

Call Janis Crowley in the U.S. at (212) 496-7704 or fax to (202) 682-0816.In Europe call (44) 0223 302067 or fax to (44) 0223 302068.

Director of the School ofEnvironmental Studies

* § Queen's University is establishing a School ofEnvironmental Studies within the Faculty of Artsand Science. The School will assume responsibil-ity for the Faculty's undergraduate EnvironmentalScience Program. It will conduct environmental-science research, foster collaboration among fac-ulty in natural-science, social-science and hu-

manities departments and in other Faculties and Schools, and promoteteaching related to the environment, especially in the social sciences andhumanities. It will be housed in Queen's new Biosciences Complex.We are seeking candidates for the position of Director of the School.

The successful candidate will have a strong research track-record and ademonstrated commitment to high-quality teaching in a natural-sciencediscipline, with particular experience relevant to environmental science.The Director will be expected to provide intellectual and administrativeleadership to a growing interdisciplinary enterprise.

The successful candidate will be appointed at a rank and salarycommensurate with experience and qualifications to a tenure-track ortenured faculty position in the appropriate department (Biology, Chem is-try, Geography or Geological Sciences), and will also be appointedDirector of the School for a five-year term. The appointment will com-mence 1 July 1995.

Applications, including a curriculum vitae, copies of recent scholarlypublications, and the names of at least three persons who can provideletters of reference, should be sent to the above address by 1 October1994.

In accordance with Canadian immigration requirements, this adver-tisement is directed to Canadian citizens and permanent residents.Queen's University has an employment equity program, welcomes diver-sity in the workplace, and encourages applications from all qualifiedcandidates including women, aboriginal peoples, people with disabili-ties, and members of visible minorities.

Additional information Dr. John M. Dixon, Associate Deanconcerning this position Faculty of Arts and Science

and the School can be Queen's Universityobtanedrom he Cair Kingston, Ontario, Canada K7L 3N6

obtained from the Chair Tel 613 545-2448

of the Search Committee: Fax 613 545-2067e-mailDIXONJ@QUCDN.OUEENSU.CA

LOYOLA

UNIVERSITY

CHICAGO

The Stritch School of Medicine, Loyola University ofChicago, is seeking applications and nominations to theposition of Professor and Chair, Department of Surgery.The successful candidate will not only have the oppor-tunity to assume the leadership of a strong, maturefaculty but also have the opportunity to diversify thedepartment in new areas of interest.

Candidates should be nationally recognized and havethe qualifications and experience to direct a major aca-demic surgical program.

Loyola University is an equal opportunity, affirmativeaction employer in its 124th year of service to theChicago area and the nation.

Nominations along with curriculum vitae should be sentto:

Leonard L. Vertuno, MDChairperson, Search Committee forChairperson, Department of Surgery

Stritch School of MedicineLoyola University of Chicago2160 South First AvenueMaywood, Illinois 60153

!Agracetus, Inc.

Agracetus, Inc., isa recognized leaderin developing transgenic product so-lutions for the biopharmaceutical andfiber industries. Our PLANT BIORE-ACTORPROGRAM is currently seek-ing an independent and creative indi-vidualto join an expanding multidisci-plinary team to develop transgenicplants as a production system fortherapeutic proteins and industrialenzymes.

RESEARCH SCIENTIST -PLANT GENE EXPRESSION

The successfulcandidate should havedemonstrated experience in plantgene expression. Expertise in expres-sion of heterologous proteins in seedsis highly desirable. A Ph.D. is re-quired and relevant postdoctoral re-search is beneficial.Agracetus has a state-of-the-art facil-ity located near the University of Wis-consin, Madison. We offer an excel-lentcompensation and benefitspack-age. Send resume with three refer-ences to: Human Resources, Agrace-tus, Inc., 8520 University Green,Middleton, WI 53562. FAX: 608-836-9710. Equal Opportunity Employer.

9IMPIR C L"i1 a

The Division of Preventive Oncology of the Ontario Cancer Treatment and Research Foundation(OCTRF), through its regional centres, provides a province wide system of cancer prevention,treatment, research and education. We are currently seeking a creative and innovative individual forthe new position of...

Director, Ontario Cancer Genetics NetworkThis is a province wide network which will develop and evaluate new genetic tests for predispositionto cancer. The network includes the eight Regional Cancer Centres of the OCTRF, as well as facilitiesof the Division of Preventive Oncology, which include the Division of Epidemiology, the Ontario BreastScreening Programme and the Ontario Cancer Registry.

The successful candidate will possess anMD and /or PhD degree plus a minimum of 5 - 10 years relatedexperience. The successful candidate should be an established scientist with research interests in oneor more of the fields of molecular biology, genetic epidemiology, the clinical management andcounselling of individuals who carry genes that predispose to cancer, or the ethical aspects of genetictesting.

Qualified applicants are invited to forward an updated curriculum vitae and the names of three refereesas soon as possible to: Dr. N. F. Boyd, V.P. Division of Preventive Oncology, 620 UniversityAvenue, Toronto, Ontario, Canada M5G 2L7.

In accordance with Canadian immigration requirements, preference will be given to Canadian citizensand permanent residents of Canada. Overseas candidates may also be considered.

THE ONTARIO CANCER TREATMENT AND RESEARCH FOUNDATION

MOLECULAR TOOL, INC.

MolecularTool, Inc. is abiotechnology com-pany located in Baltimore, Maryland com-miued to the development and commercial-ization of highly integrated, DNA-based sys-tems for the analysis of complex genornesand genetic loci. Together with key industrypartners, Molecular Tool has embarked on asignificant research and productdevelopmentprogram for the near-term implementation ofa large-scaleDNA analysis system and has anexciting opportunity for a Ph.D. Enzymolo-gist to join its Biochemistry group.

BIOCHEMISTIENZYMOLOGIST: Candi-dates must have a Ph.D. in biochemistry or arelated field and experience in nucleic acidbiochemistry and enzymology. Industrialpostdoctoral research experience in DNApolymerases is aplus. The selected candidatewill work with a multidisciplinary team onthedevelopmentand implementation ofDNAdiagnostic products.

Situated on a campus of the Johns HopkinsUniversity School of Medicine, MolecularTool, Inc. offers a stimulating technical envi-ronment, competitive salaries, incentive pro-gram and medical insurance benefits. Inter-ested candidates should send a resume andsalaryhistory to: DS., MolecularTool, Inc.,Alpha Center, Hopkins Bayview ResearchCampus, 5210 Eastern Avenue, Baltimore,MD 21224. EOE.

ASSISTANT DIRECTOR/ASSISTANTSCIENTIST for Center for Neurobiologyand Immunology Research (CNIR) at theUniversity of Kansas. Dudes include as-sisting in coordination of CNIR interac-tions with private sector companies, pro-moting technology transfer to the privatesector, supervising the day-to-day workof CNIR staff, and functioning as directorof Tissue Culture/Hybridoma Laboratory.Required Qualifications: Ph.D. in Neuro-biology and Immunology; 2 yrs. post-doctoral experience in the biosciences,biotechnology or pharmaceutical arena;and experience in management of labo-ratory facilities and scientific personnel.Preferred: Experience as independent in-vestigator in cell culture, monoclonal an-tibodies, neurotoxicity screening, proteinpurification, and/orcDNA cloning; experi-ence in technology transfer to the phar-maceutical or biotechnology industry andbusiness negotiations. Full time, 12months, annually renewable position.Salary range:$45,000 to 50,000/year plusfringe benefits. SubmitCV, academictran-scripts and three letters of recommenda-don byAugust8, 1994to Dr. E.K. Michae-lis cdo Anette Lundsgaarde, Higuchi Bio-sciences Center, University of Kansas,West Campus, 2099 Constant Avenue,Lawrence, KS 66047-2535. 913-864-5183. The University of Kansas is anequal opportunity/affirmative action em-ployer.

University of MinnesotaCancer Center

Endowed Chair in Breast Cancer

The University of Minnesota Cancer Center, incollaboration with the Departments ofMedicineand Surgery at the University of Minnesota isestablishing a new seniorendowed faculty posi-tion in breast cancer research. The chosen indi-vidual willbenamed tothe Tickle Chair in breastcancer. The individual will be responsible forproviding leadership to the University's breastcancerprogramand developing innovative trans-lational clinical programs in breast cancer detec-tion, prevention and treatment. Candidates musthave a medical degree, experience in medical orsurgical oncology, and a proven record of highquality research (as shown by acceptance forpublication of papers in quality, peer-reviewjournals. Candidates willbeexpected todevelopa strong research program leading to externalfunding). The academic appointment will be ina University department suited to the skills ofthesuccessful candidate. Strong emphasis will beplaced upon the candidates' ability to interactwith other members of the group, the CancerCenterand Department,and the University con-munity. Teaching and advising will be done inthe appropriate graduate program(s) and in theDepartment(s) in which the primary appoint-ments are held.

Please send a curriculum vitae, a brief researchstatement, and three letters of recommendationto: Gordon Ginder, M.D., Chair, Search Com-mittee, University of Minnesota Cancer Center,Box 806,420 Delaware Street S.E., Minneapo-lis, MN 55455-0392, U.S.A. The last date forreceipt of applications is November 1, 1994.

77h UIwvrsity ofMimesota is an equal opportnuty educatorand eoyer.

1

POSITIONS OPEN

MOLECULAR BIOLOGIST. Research focus is ongenes encoding membrane receptors, adhesion mole-cules, and key enzymes involved in transmembrane sig-naling, and synthesis/degradation of carbohydrates andlipids. Position requires (1) solid experience in cloning,cfharacterzation, and expression/transfection of genes meukaryotic cells; and (2) dose collaboration with otherscientists on regulatory mechanisms of these genes forexpression of receptors and enzymes involved in regula-tion of cell adhesion and transmembrane signaling. Sal-ary and job title will depend on qualifications andexperience. The Institute is affiliated with the UniversityofWashington. Good fringe benefits. Send cover letter,curriculum vitae, and three reference letters to: StephenAnderson, Ph.D., The Biomembrane Institute, 201Elliott Avenue West #305, Seattle, WA 98119-4230. No telephone calls or faxes. Equal OpportunityEmployer.

TERRESTRIAL ECOLOGISTWe seek an experienced ecologist to coordinate and

conduct research and develop support for long-termecological research at the Idaho National EngineeringLaboratory. Universities assist in these activities. Can-didates should have a Ph.D., success in obtainingsupport from federal agencies, excellent verbal andwritten communication, experience in semiarid systemsand education/experience in one or more areas: plantecology, systems ecology, radioecology, hydrology,pollutant monitoring or research, ecological risk assess-ment; US citizenship required. A letter, resume includ-ing 1 to 3 pages of research accomplishments, tran-scripts and 3 letters of reference to: Dr. Doyle Mark-ham, Environmental Science & Research Founda-tion, P.O. Box 51838, Idaho Falls, ID 83405. FAX:208-525-7036.

BIOCONTROL TECHNOLOGY, INC. the leaderin non-invasive glucose measurement is seeking a BIO-CHIEMIST/BIOLOGIST/BIO PHYSICIST. Thesuccessful candidate will be responsible for characteriz-ing, modeling, and understan skin with special em-phasis on the optical properties of skin. Candidates musthave strong backgrounds in: NIR spectroscopy, physi-ology, chemistry, and experimental methods. In addi-tion, the candidate shouldlhave a Ph.D. or equivalent andexperience in several of the following areas: Optics,Monte Carlo Modeling, Diffise reflection, Bio-Chemis-try, Raman Spetroscopy, Biochemistry, Anatomy, andPhysical Chemistry. Interested candidates should FAX:(412) 349-8610, or mail a cover, salary requirements,and r&sumE to: Human Resources, Biocontrol Tech-nology, Inc., 300 Indian Springs Road, Indiana, PA15701. Equal Opportunity Employer. Male/Female/Disa-beltVdVeterans.

POSTDOCTORAL RESEARCH ASSOCIATEIN MOLECULAR BIOLOGY position available Au-gust 1, 1994, for two years. The incumbent will work onpeptide gene expression in baculovirus vector systems,characterization of hormone receptors in insects andisolation and characterization of an insect specific virus.Salary: $35,000 plus benefits. Must be a U.S. citizen.Please send your curriculum vitae to: Dr. Ashok LaRaina, Bldg. 306, Room 313, BARC-East, Beltsville,MD 20705-2350. Telephone: 301-504-9396.

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The latest addition to the QlAexpresssystem is our new Ni-NTA Spin Kit forprotein minipreparation. Use it to quicklyscreen clones for expression, or to purify

__ small amounts of protein._ And QlAexpress is more than just a great

way to express and purify proteins. The6xHis tag is small, poorly immunogenic,

M and rarely has to be cleaved from thetnrnf29 protein after purification.pH63; To find out more about how simple

protein purification can be, call QIAGENor your distributor soon and ask about QlAexpress System

C-terminus of and Ni-NTA resin.

the high level Nothing could be more simple.

QIAGEN GmbiK Max-Volmer-Strd3e 4, 40724 Hilden, Germa, Orders (0)2103-892-230, Fax (0)2103-892-222, Technical Service (0)2103-892-240QIAEN ne.: 9600 De SooAvenue, Chotworth, CA 9131 1, USA, Orders 800-426-8157, Fax 818-718-2056, Technical Service 800-DNA-PREP (800-362-7737)DIS5 RS A IA: BRESATEC Lid. (08-234 2644 AUSTIA:I BIO-TRADE (11-8891819 SENEWMi Westburg B.V. NL (033)-950094B: (078)-119815 (toll free) DENMAR^. S s KEBO (43)-86 8788 FINLAND: KEBO Lob Oy (0)-804 4900 FRANCE: Coger (1)-45-32-35-17GREECLBiontiL.d(01)-6436138 HONGKONG/CHINA:Amwaltntoemaliond.t(852)7245082 INDLzGenelix:( 1 1)-5467637 ISRAELBIO-LABL 1borotrie Lid. (02)-524447 ItALY.: Genenco (M-Medicl sr) (055) 5001871 JAPAN: FUNAKOSFt Co., Ltd. (03)-5684-1620 KOREA: IRS labo ries,kic. (02) 924-8697 NORWAY: KEBO Lab 22903000 PORIA ZASA PORTUGAL, LDA (1)-7570740 RSA: WHITEHEAD SCIENIlFIC SUPPUES(021) 981 1560 SINGAPORE:- TIBS Trading Pbe Ltd. (Biotedh Brandh) 292 9783 SPAIN: IZASA SA (91)-663-05-00 SWEDEN: KEBO Lab (081 621 34 00SWTZERLAND: KONTRON lnsuen AG (01)-733-5-733 TAIWAN: Formo Industriol Co., Ltd. (021736-7125

Circle No. 1 on Readers' Service CardQIAGEN

Custom

GenotypingFast * Economical * Confidential

With the opening of the Research Genetics Genotyping Center, allinvestigators now have access to high throughput genotyping without havingto give up control of their work. Typical genotyping projects involvinghundreds of markers can be completed in under 60 days. Complete resultsincluding both the raw genotyping data and computer files suitable for useby linkage software are provided.

To support this new center, we have produced over 1,400 different dye-labeled microsatellite markers for use on the Applied Biosystems Model373 Sequencer. A genome wide screening set, made up of a subset of thesemarkers, is currently being tested. Even finer mapping can be performedusing isotopically labeled markers from our selection of over 4,000 humanmicrosatellite markers or custom markers may be developed.

Prices range from $2.50 to$3_$350 per genotype dependingon the project. There is a setupfee of $10 perDNA sample tocover quantitating, aliquoting,initial testing and archiving.

Research Genetics2130 Memorial Pkwy, SW * Huntsville, AL * 35801

U.S. or Canada 800-533-4363 * U.K. 0-800-89-1393 * FAX 205-536-9016Circle No. 3 on Readers' Service Card