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    CASE STUDY

    ORAL CANCER

    Submitted By:-

    POOJA THAKKAR

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    Patient profile

    Name-NagammaAge-60 years

    Sex-female

    Doctor-NSG

    Diagnosis-CA of tongue

    Length of hospital

    Family size-6 adult, 2 children

    Occupation-cateringFood habit-no vegetarian

    Ethnic background-telgu

    Residence-Mumbai (vile Parle)

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    Anthropometry measurements

    Height-143cmPreoperational weight-46 kg

    Post operation weight-45 kg

    Ideal body weight-44kg

    Body mass index-22.5kg meter square

    Subjective global assessment D GRADE

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    Clinical findings

    Case of ulcerative proliferative growth on the right lateralborder since two months, along with pain.

    History of dysphagia can tolerate liquid diet.

    History of haemetasis

    History of tobacco chewing for more than 30 years, 5 to 6

    times daily.

    And consuming tea 6-7 times a day

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    Investigation

    Biopsy of tongue-lesion of squamous cell (CA)USG-appearance of suggestive neoplasm along middle and

    posterior third right lateral border of oral tongue measuring

    3cm *1.6cm*2.6cm. No involvement of basal tongue few

    enlarge lymph node noted in deep cervical region bilaterallyleft side 2cm*0.8*1.6.

    Microscopy- all tissue processed section shows tumor tissue

    with feature of invasive moderately.

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    Name dosage Justification

    Inj.Augmentin Iv 12 hourly Bacterial infection

    Inj.flagyl Iv 8 hourly Antibacterial

    Inj.tramdol Iv 8 hourly Painkiller

    Inj.Rantac Iv 8 hourly Antidiarrhoeal

    Inj.Deca Iv 12 hourly Steroid injection

    1PintRL

    1PintDNS

    1PintNS

    For maintaining blood

    volume

    Syrup combiflam 10ml-0-10ml Painkiller

    Syrup tonoferon 10ml-0-10ml Iron supplement

    Syrup regamil 10ml-0-10ml Multivitamin

    Medication (21/6/11-27/6/11)

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    Review of literature

    Tongue cancer is a common type of cancer which is calledsquamous cell carcinoma. The tumor is usually is located on the

    side lateral border of the oral tongue. It is usually ulcerated and

    is grayish pink to red colour. It will bleed easily if beaten or

    touched. Larger cancers may indeed have some effect on speech

    and swallowing. Smoking alcohol, chewing tobacco is known to

    contribute to the formation of cancer. In case of oral cancer it can

    be treated by just removal of primary tumor in the tongue. As the

    size of the tumor increases, the possibility of spreading through

    lymph vessels to the lymph nodes of the tongue increases.

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    Causes of tongue cancer

    Tobacco-use accounts for most oral cancer. Smoking

    cigarettes, cigars, chewing tobacco and other products. The

    risk of cancer is even higher for those who consume tobacco

    and also drink. The risk increases with the amount of alcohol

    the person consumes. People who have had head, neck cancerare at higher risk of developing another primary head and

    neck cancer on smoking

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    Signs and symptoms of tongue cancer

    Patches inside the mouth or on the lips that are white

    patches, a mixture red and white or red patches

    White patches (leukoplakia) are most common. White

    patches sometimes become malignant.

    Mixed red and white patches (erythroleukoplakia) are

    more likely than white patches to become malignant

    Red patches(erythroplakia) are bright coloured,smooth areas that become malignant

    A sore on lips or in the mouth that wont heal, leads to

    bleeding in the mouth, difficulty in swallowing and lump

    in the neck

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    Diagnosis

    Oral cancers can be diagnosed by some physical examinationsuch as red and white patches, lumps, swelling or other

    problem in the mouth or the throat. The biopsy is also done

    with local generalized anesthesia. A biopsy is the sure way to

    know if the abnormal area is cancerous.

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    Treatment

    If the biopsy shows cancer is present, the stage of the diseaseis evaluated and the treatment is correctively taken. The stage

    is based on the size of the tumor and the areas it has been

    spread to. The surgery hemiglossectomy involves removal of

    a part of a tongue and its adjacent tissues.

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    Name Normal value 6/6/11 22/6/11

    WBC 4-11*103/ul 4.7*103/ul 14.1*103/ul

    Lymphocyte 1.4-3*103/ul 2.0*103/ul 1.9*103/ul

    Monocyte 0.1-0.7*103/ul 1.3*103/ul 0.3*103/ul

    Granulocyte 2.8-5.8*103/ul 1.4*103/ul 11.9*103/ulLymphocyte % 25-45% 42.3% 13.5%

    Monocyte % 4-7% 29.9% 2.1%

    Granulocyte % 45-70% 27.8% 84.4%

    RBC 3.50-5.60*106/ul 4.47*106/ul 3.64*106/ul

    Hgb 11-18g/d 11.4g/d 10.5g/d

    HCT 32-54% 38% 33.1%

    MCV 79-101 fl 85fl 90.9fl

    MCH 26-36pg 25.5pg 28.8pg

    MCHC 31-37g/dl 30g/dl 31.7g/dl

    RDW 11.5-14.5% 14% 11.7%

    PLT 120-500*103/ul 27*103/ul 226*103/ul

    PCT 0.130-0.280% 0.2% 0.160%

    MPV 9-17 fl 7.8 fl 7.1flPDW 11.5-14.5 fl 7 fl 11.9fl

    FBS 70-110 mg/dl 104 mg/dl 103mg/dl

    PLBS

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    Time Menu Amount Energy

    (Kcal)

    CHO

    (gms)

    Prtn

    (gms)

    Fat

    (gms)

    Na+

    mEq

    K+

    mEq

    9 am Cutting tea

    Sugar

    pav

    2tsp

    2 nos

    21

    40

    200

    1.32

    10

    40

    0.96

    ----

    0.75

    ----

    21.9 42

    2pm Rice

    DalRoti

    60 gms

    15 gms60 gms

    200

    50200

    42

    8.542

    3.6

    3.55

    1

    0.251

    4.8

    412

    40.8

    197189.2

    4 pm Tea

    Sugar 2tsp

    21

    40

    1.32

    10

    0.96 0.75 21.9 42

    9.30 pm Dal

    /fish/mutto

    n

    /chicken

    Rice

    roti

    15 gms

    60 gms

    60 gms

    50

    200

    200

    8.5

    42

    42

    3.5

    3.6

    5

    0.25

    1

    1

    4

    4.8

    12

    197

    40.8

    189.7

    Total oil 30 gms 270 30

    TOTAL 1492 247.6 26.12 36 3.7 24

    Home recall of the patient (a month ago)

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    Medical nutritional therapy

    Objective-

    To give neutropenic diet

    Avoid further catabolism

    Avoid reduction in lean body mass

    Meet additional immune nutrient requirements

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    energyan estimate of 45-50Kcal per present body weight is

    given as cancer is a stressful condition

    carbohydrateabout 60% of energy is recommended to comefrom carbohydrates so as to conserve lean body mass and to

    prevent protein breakdown.energy from mainly simple carbs

    should be avoided

    Fatsabout 20-30% of energy should come from fats which is

    calorically dense source of energy and also helps in absorption ofvitamins and minerals SFA:MUFA:PUFA ratio has to be

    maintained ,not more than 40% of PUFA should be given as it

    has immunosuppressive effect

    Proteinabout 1.5-2 gms per present body weight is given tomaintain nitrogen balance, avoid muscle proteolysis and for

    tissue growth.

    Vitamins and mineralsincrease quantity of vitamins and

    minerals are needed in high amount for their wound healing and

    antioxidant property .Given requirement by FDA

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    Vitamin A 3300 IU

    Vitamin D 200 IU

    Vitamin E 10 IU

    Vitamin K 150 ug

    Vitamin C 200mg

    Vitamin B1 6mgVitamin B2 3.6mg

    Vitamin B3 40mg

    Vitamin B6 6mg

    Vitamin B12 5ugZinc 2500-4000 ug

    Copper 300-500ug

    Chromium 10-15 ug

    Manganese 60-100 ug

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    Glutamine 60mg/d (0.6g/PBW)

    Arginine 9gm

    Omega3 1.8-2gm/d

    Fluid need -1ml/kcal of energy

    Immunonutrient- since patient is non affording enough sourceof milk and egg was given to meet adequate amount of

    glutamine & arginine.Also fish cod liver oil was given to meet

    omega 3 requiremnt.

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    Hospital diet

    20/6/11-surgery

    21/6/11-NBM

    22/6/11-referred for diet

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    Energy (Kcal) 2250 (50Kcal/PBW)

    CHO (gms) 303 (54%)

    Prtn (gms) 90 (2gm/PBW)

    Fat (gms) 75 (35%)

    Fluid (ml) 2125

    Requirement of patient

    Energy=PBW*50kcal45*50=2250kcals

    Protein=2gm/PBW2*45=90gm360kcal16%

    Fats=35% 787kcals75gms

    CHO54%1215303gms

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    Time Menu

    12.30 pm 25cc kanji/soup

    2.30 pm 50cc kanji/soup

    4.30 pm 75cc kanji/soup6.30 pm 100cc kanji/soup +1tsp PHP

    8.30 pm 125cc kanji/soup +2tsp PHP

    10.30 pm 100cc milk + 3 tsp PHP

    22/6/11 TEST FEED

    (PHP-pentasureHP)

    Urine output: 820ml

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    Energy-1740 Kcal(39Kcal/PBW)

    Na+ 49mEq Total volume of feed-1350cc

    CHO-180gm (41%) K+ 56mEq Volume from formula

    feed-1050

    PRTN-

    62.7gm(1.5gm/PBW)

    NNC-1490Kcal No of formula feeds-5

    FAT-67gm (34%) Cal:N2 174:1 Volume per formula

    feed-210cc

    23/6/11 -24/6/11FORMULA FEED

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    name Exchange Energy

    (Kcal)

    CHO

    (gms)

    Prtn

    (gms)

    Fat

    (gms)

    Na+

    mEq

    K+

    mEq

    Rice 3(90gms) 300 63 5.4 1.5 7.2 61.2

    Dal (15gms) 50 8.5 3.5 0.25 4.2 197

    Milk 9(900ml) 630 39.6 28.8 22.5 657 1260

    wholeEgg

    2 170 13 13 342 322

    Vegetable

    pulp

    (vegA)

    4 100 24 108

    Fish Cod

    liver Oil

    30gm 270 30

    Sugar 30gm 120 30

    PHP 30gm 100 15 12 120 240

    Total 1740 180 62.7 67.25 49 56

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    Time Menu

    9.30 am 150cc milk+ 3tsp PHP

    11.30 am 210cc formula feed +1tsp zincovit syrup

    1.30pm 210cc formula feed

    3.30 pm 210cc formula feed +1tsp zincovit syrup

    5.30 pm 210cc formula feed

    7.30 pm 210cc formula feed +1tsp zincovit syrup

    9.30 pm 150cc milk+ 3tsp PHP

    23/6/11 -24/6/11

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    Energy-1740 Kcal(39

    Kcal/PBW)

    Na+ 49mEq Total volume of feed-

    1350ccCHO-180gm (41%) K+ 56mEq volume of formula

    feed-1050cc

    PRTN-

    62.7gm(1.5gm/PBW)

    NNC-1490Kcal No of formula feeds-5

    FAT-67gm (34%) Cal:N2 174:1 Volume per formula

    feed-210cc

    Observation

    Following days no aspiration was seen using Ryles tube and after

    2 days patient was started on oral sips.

    Average calorie of 2 days of hospital recall

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    Energy-2225 Kcal(50

    Kcal/PBW)

    Na+ 62mEq Total volume of feed-

    1600cc

    CHO-231gm (41%) K+ 72mEq volume of formulafeed-1300cc

    PRTN-

    84gm(1.9gm/PBW)

    NNC-1889Kcal No of formula feeds-5

    FAT-87gm (35%) Cal:N2 171:1 Volume per formula

    feed-260cc

    25/6/11 step up + oral sips

    actual requirements for the patient has been met

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    name Exchange Energy

    (Kcal)

    CHO

    (gms)

    Prtn

    (gms)

    Fat

    (gms)

    Na+

    mEq

    K+

    mEq

    Rice 4(120gm) 400 84 7.2 2 9.6 81.6

    Dal 1(30gm) 100 17 7 0.5 8.4 394

    Milk 10(1000m

    l)

    700 44 32 25 730 1400

    whole

    Egg

    3 255 19.5 19.5 513 483

    Vegetable

    pulp

    4 100 24 108

    Fish cod

    liver Oil

    40gm 360 40

    Sugar 40gm 160 40

    PHP 45gm 150 22.5 18 180 360

    Total 2225 231 84 87 62 72

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    Time Menu

    9.30 am 150cc milk+ 4 tsp PHP

    11.30 am 260cc formula feed +1tsp zincovit syrup

    1.30pm 260cc formula feed

    3.30 pm 260cc formula feed +1tsp zincovit syrup

    5.30 pm 260cc formula feed

    7.30 pm 260cc formula feed +1tsp zincovit syrup

    9.30 pm 150cc milk+ 4 tspPHP

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    Time Menu

    10.30 am 50 cc kanji/soup

    12.30 pm 50 cc kanji/soup

    2.30 pm 50 cc fruit juice without sugar

    4.30 pm 50 cc coconut water

    6.30 pm 50 cc soup/kanji

    Oral sips started along with feed

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    Observation

    Patient had tolerated the RT and oral sips were also tolerated butcoconut water was not consumed

    Care was taken that the soup was not hot and no straw was used

    by the patient

    26/6/11 Discharge diet

    RT +oral clear liquid diet

    Taking into consideration to meet the recommended vitamins,

    mineral, fluids and immunonutrients through the diet by usingvarious sources

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    Energy-2325 Kcal(51 Kcal/PBW) Na+ 76mEq Total amount of fluid from diet-

    2650ml

    CHO-251gm (43%) K+ 76mEq

    PRTN-84gm(1.9gm/PBW) NNC-1989Kcal No of feeds-17

    FAT-87gm (35%) Cal:N2 178:1

    name Exchange Energy

    (Kcal)

    CHO

    (gms)

    Prtn

    (gms)

    Fat

    (gms)

    Na+

    mEq

    K+

    mEq

    Rice 4(120gm) 400 84 7.2 2 9.6 81.6

    Dal 1(30gm) 100 17 7 0.5 8.4 394

    Milk 10(1000ml) 700 44 32 25 730 1400

    whole Egg 3no 255 19.5 19.5 513 483

    Vegetable

    pulp

    4 100 24 108

    Fish codliver Oil

    40gm 360 40

    Sugar 40gm 160 40

    PHP 45gm 150 22.5 18 180 360

    fruits 2no. 100 20 70 140

    Total 2325 251 84 87 76 76

    Time& menu Amount Ingredients

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    g

    7.30 am-raisin milkshake 200cc 200 ml milk+

    Soaked and ground raisens+4 tsp of PHP

    8.30 am 50 cc Boiled Water

    9.30 am-orange juice 200 cc Sweet lime juice (2 no.) +

    2 tsp sugar +1tsp zincovitsyp10.30am 50 cc Boiled Water

    11.30am- eggnog 250 cc 200 ml Milk +1 egg +

    2 tsp sugar+1capsule of cardepa

    12.30pm(15gms rice) 50 cc Rice kanji

    1.30pm khichdi 300 cc 15gm rice +

    15gm dal +200 ml vegetable soup + 2 tsp fish oil+1tspzincovitsyp+ squeezed lime

    2. 30 pm (15 gms rice ) 50 cc Rice kanji

    3. 30 pm- egg nog 250 cc 200 ml milk +1 egg +2 tsp sugar+1capsule of cardepa

    4. 30 pm (15gms rice ) 50 cc Rice kanji

    5. 30 pm -raisin milkshake 200 cc 200 ml milk +Soaked and ground raisins 2 tsp sugar+2

    tsp fish oil

    6. 30 pm (15gms rice) 50 cc Rice kanji

    7. 30 pm -rice&soup 300 cc 30 gm rice +200 m vegetable soup+2tsp fish oil

    8. 30 pm 50 cc Boiled water

    9.30 pm- khichdi 300 cc 15gm rice +15 gm dal+2 tsp fish oil+200cc vegetable

    soup+1tsp zincovit syp+ squeezed lime10.30 pm 50 cc Boiled water

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    Time Menu

    10.30 am 50 cc kanji

    12.30 pm 50 cc soup

    2.30 pm 50 cc fruit juice without sugar

    4.30 pm 50 cc coconut water

    6.30 pm 50 cc soup

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    follow up on 4/7/11 to remove sutures, and test soft diet intake

    discharge diet of 2600cc -->energy 50kcal/PBW,prtn-1.9gm/PBW(highfluid,vitamin, mineral, immunonutrient)

    Diet of1600cc --> energy 50kcal/PBW,PRTN 1.9gm/PBW + oral sipstartedopening of mouth is very little and sips are taken with help of a spoon

    diet of 1350cc-->energy 39kcal/PBW,prtn1.5/PBW (2days)

    WEIGHT LOSS OF 1 KG & URINE OUTPUT 700ML TO 1005 ML

    CANCER OF TONGUE

    NBM TEST FEED

    PROGRESSION

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    RECOMMENDATION

    Keep the patient in upright position while feeding.

    Keep the patient upright for 30mins after feedingIf the aspiration is more than 50% stop feeding and feed after 2 hrs

    Keep the feed outside the refrigerator for 30 mins before giving the patient

    Avoid raw foods for the patient

    Consume boiled water

    Maintain sanitized utensil for the patients food Store the prepared feed on table not more than 2 hrs, and refrigerated feed

    for not more than 4 hrs.

    Avoid consuming packet juice ,soups, puree, and nonveg soup

    Maintain clean sanitary condition of the person feeding the patient as it may

    lead to cross contamination.

    Wash the RT with 20 ml distilled water after every feed

    Restrict using food thickeners like potato, sweet potato, cornflour, arrowroot

    through RT

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