poisoning pwm olly indrajani 2014. acetaminophen
TRANSCRIPT
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PoisoningPWM OLLY INDRAJANI
2014
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ACETAMINOPHEN
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Introduction • Recommended dose, (every 4-6 hours) :
– Adults = 650 – 1000 mg (max. 4 gr)– Children = 10 – 15 mg / kgBW (max. 75 mg/kgBW)
• Absorbed rapidly.
• Peak plasma concentration = ± 1 hour; complete absorption = ± 4 hours.
• Absorbed inhibits PGE2 synthesis by -direct COX-2 inhibition or- inhibition of membrane-associated PG synthase antipyretic, analgesia.
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Pathophysiology
A. After ingestion of therapeutic amounts, predominant metabolism is via glucuronidation and sulfation. The small amount of N-acetyl-p-benzoquinoneimine (NAPQI) generated is metabolized by adequate glutathione stores to a nontoxic compound.
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Pathophysiology
B. After ingestion of large amounts, glucuronidation and sulfation are saturated, and an increased amount of NAPQI is generated. Metabolism of NAPQI to a nontoxic compound soon depletes glutathione stores, leaving excess NAPQI to bind to intracellular proteins, causing cell death. APAP = N-acetyl-p-aminophenol (acetaminophen).
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Clinical Features
Source : Rosen’s Emergency Medicine – Concepts & Clinical Practice,7th ed. , 2010
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Diagnosis
• A toxic exposure to acetaminophen is suggested when an adult ingests : (1) >10 grams or 200 mg/kg as a single ingestion, (2) >10 grams or 200 mg/kg over a 24-hour period,
or (3) >6 grams or 150 mg/kg per 24-hour period for
at least 2 consecutive days.
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Management • Acetylcysteine Dosing Regimens
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Management
• Limiting GI absorption : consider early gastric emptying in cases of recent, life-threatening congestions.
• N-Acetylcysteine (NAC) : delay of administration of NAC > 6-8 hrs after ingestion ↑ risk of hepatotoxicity.
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Management • Treatment guidelines for acetaminophen (APAP)ingestion .
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ASPIRIN & SALICYLATES
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Pharmacokinetics
• Absorbed from the GIT within 30’ (2/3 in 1 hrs); peak levels = 2-4 hrs.
• Intestinal wall, liver, RBCs : aspirin hydrolyzed free salicylic acid reversibly binds to albumin.
• Liver : conjugated w/ glucuronic acid & glycine.• Renal excretion : free salicylate & its
conjugates.
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Patophysiology
Acid-base disturbances & metabolic effects.• Stimulates the medullary respiratory center &
↑ the sensitivity of the respiratory center to pH & pCO2 hyperventilation metabolic acidosis.
• Toxicity : interference w/ aerobic metabolism uncoupling of oxidative phosphorylation .
• Inhibition of Krebs cycle ↑ production of pyruvic acid & conversion to lactic acid.
• ↑ lipid metabolism ↑ production of ketone bodies.
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Patophysiology
• Tissue glycolysis hypoglycemia. • Hepatic gluconeogenesis & release of
adrenaline hyperglycemia.• Inefficiency of anaerobic metabolism less
energy used to create ATP energy is released as heat hyperthermia.
• pH ↓ more salicylate particles become un-ionized cross the cell membrane & BBB ↑ movement of salicylate into the tissues & CNS.
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Patophysiology
Fluid & Electrolyte Abnormalities.
• ↓ renal blood flow / direct nephrotoxicity acute non-olyguric renal failure.
• Induce secretion of inappropriate ADH affect renal function.
• Potassium loss : (1) vomiting, secondary to stimulation of the medullary chemoreceptor trigger zone;
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Patophysiology
(2) increased renal excretion of sodium, bicarbonate, and potassium as a compensatory response to the respiratory alkalosis; (3) salicylate-induced increased permeability of the renal tubules with further loss of potassium; (4) intracellular accumulation of sodium and water; and (5) inhibition of the active transport system, secondary to uncoupling of oxidative phosphorylation.
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Patophysiology
• ↑ pulmonary vascular permeability Noncardiogenic Pulmonary Edema .
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Clinical Features
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Management
Source : Rosen’s Emergency Medicine – Concepts & Clinical Practice,7th ed. , 2010
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METHANOL
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INTRODUCTION
• Colorless, volatile, slightly sweet-tasting alcohol.
• Methanol intoxication in the US (2006) : 73% unintentional, 8% moderate-major complications, 8 fatalities.
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PATOPHYSIOLOGY
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CLINICAL FEATURES
• Early symptoms : depressed mental status, confusion
• Non-specific : weakness, dizziness, headache, anorexia, nausea, vomiting, abdominal pain
• Severe : coma, seizure• Visual disturbances : “snow field” vision
• Minimal lethal dose = 50 - 100 mL
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TREATMENT
• Ethanol
• Fomepizole
• HD
• Folic acid
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TREATMENT
• American Academy of Clinical Toxicology recommends ethanol / fomepizole criteria:– Plasma methanol concentration > 20 mg/dL, – Recent hx of methanol ingestion with serum
osmolal gap > 10 mOsm/L , or – Strong clinical suspicion of methanol poisoning
with at least 2 of the following :• Arterial pH < 7,3; serum , • HCO3- < 20 mEq/L, • osmolal gap > 20 mOsm/L.
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ETHANOL
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INTRODUCTION
• Rapidly absorbed
• Peak blood levels ± 30’ - 60’ after ingestion
• Eliminated via hepatic metabolism
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PATHOPHYSIOLOGY
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CLINICAL EFFECTS
• Behavioral• CNS depression• Respiratory depresssion, coma.• Nausea, vomiting• Peripheral vasodilatation
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MANAGEMENT
• Activated charcoal
• IV glucose
• Thiamine
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ORGANOPHOSPHATES POISONING
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INTRODUCTION
• Insecticides
• Commonly used parathion
• Accidental exposure at home, recently sprayed / fogged areas using pesticide applicators, agriculture, industry, homicides, suicides.
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• Include :– diazinon, – acephate, – malathion, – parathion, and – chlorpyrifos
Organophosphates
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PATHOPHYSIOLOGY
• Inhibits the enzyme cholinesterase excess acetylcholine accumulation at the myoneural junctions & synapses.
• Excess acetylcholine initially excites paralyzes neurotransmission at the motor endplate & stimulates nicotinic & muscarinic effects.
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CLINICAL FEATURES
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MANAGEMENT
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COCAINE
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INTRODUCTION
• Natural alkaloidal extract of Erythroxylum coca leaves (South America).
• 1st used therapeutically in 1884 for ophthalmologIc procedures.
• The 2008 National Household Survey on Drug Abuse (US) : – 5.3 million Americans had used cocaine within the past
year during 2008 : ± 700,000 new cocaine users.– 1/3 of drug-related ED visits related to cocaine use.
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PHARMACOLOGY
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PHARMACOKINETICS
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CLINICAL FEATURES
Sympathomimetics :• Hypertension• Hyperthermia• Tachycardia• Mydriasis• Diaphoresis
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MANAGEMENT
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COCAINE WITHDRAWL
• Irritability• Paranoid ideation• Delayed depression
• Symptoms of withdrawal : – strongest during the first 48 hours.– milder symptoms can last up to 2 weeks.
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THANK YOU