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ART access for pregnant women living with HIV and follow-up care for HIV exposed infants: A four country assessment of key PMTCT interventions. Priscilla Idele, PhD Co-authors: Jessica Rodrigues, Chewe Luo, Ade Fakoya, Chinyere Omeogu, Rene Ekpini - PowerPoint PPT PresentationTRANSCRIPT
ART access for pregnant women living with HIV and follow-up care for HIV exposed infants: A four country assessment of key PMTCT interventions
Priscilla Idele, PhDCo-authors: Jessica Rodrigues, Chewe Luo, Ade Fakoya, Chinyere Omeogu, Rene Ekpini
SESSION: WEAD04 Surviving and Thriving: Children, Adolescents and HIVDate: 23/07/2014 (14:30-16:00 PM)Room: Plenary 2
#PMTCT #AIDSfreegeneration. #4change #AIDS2014
Background2010 WHO PMTCT guidelines included the following options:
• Lifelong ART for eligible HIV infected pregnant women
• Two ARV prophylaxis options• Option A – AZT backbone during pregnancy and prolonged ARV
prophylaxis to baby• Option B – ART to the mother during pregnancy through breastfeeding
for HIV infected women not eligible for treatment
• Implementation of recommendations could significantly reduce the risk of MTCT and ensure increased maternal and child survival.
• The Global Fund supported countries to reprogramme existing grants towards accelerating PMTCT scale-up with more efficacious regimens
• Assess status of adoption of 2010 WHO PMTCT guidelines at the time of the assessment
• Understand how nationally adapted guidelines had been translated into action at the service delivery level
• Identify successes and current operational challenges, and highlight operational feasibility
• Assess uptake of selected PMTCT and paediatric HIV care services
Objectives
• Assessment in Tanzania, Malawi, Zambia, Lesotho between November 2011 - February 2012
• Document review - national PMTCT guidelines, scale up plans and progress reports
• Key informant interviews - national PMTCT managers and partners; district health officers and health facility staff
• 10 health facilities purposively selected in each country with Ministry of Health– Implementing 2010 guidelines; – At least 2 regions and 2 districts within the region;– urban/rural;– level of facility; and– supported by IP or not
Data and Methods
• Structured health facility questionnaires
– Availability of guidelines & provider job aids– Staffing and training– Essential laboratory diagnostics– Availability of essential medicines– Service linkages & referral mechanisms– Record keeping and monitoring tools
• Data abstraction from health facility registers and clinical records at 10 health facilities in each country and for the last quarter
Data and Methods
Pregnant women1. Uptake of maternal HIV testing during antenatal care2. CD4 testing for HIV+ pregnant women3. Uptake of ARVs/ART for HIV+ mothers (both ARV
prophylaxis, ART for mothers)Infants4. ARV prophylaxis for HIV exposed infants5. Cotrimoxazole prophylaxis within 2 months of birth for
HIV exposed infants6. Infant HIV diagnosis (EID) within 2 months of birth
Data abstraction on selected indicators
Results
Adoption of 2010 WHO PMTCT guidelinesCountry Option
chosen Rationale summary (as reported by Programme Managers)
Lesotho A
Comparable efficacy of Options A and B Acceptability Cost (CHAI PMTCT costing model) Assumed better feasibility Potential for toxicity/adverse reactions
Tanzania A
Comparable efficacy of Options A and B Assumed ease of roll-out Cost and sustainability (CHAI PMTCT costing model)
Zambia A Comparable efficacy of Options A and B Cost (rapid costing, JSI) Note: 2011-2012 pilot of option B+ feasibility in two districts
Malawi B+
Comparable efficacy of Options A and B Benefits of ART for HIV prevention Ease of implementation MCH context in Malawi (high fertility, high infant HIV, low facility deliveries
& follow-up, high post-partum mortality)
Percentage of ANC staff trained in PMTCT and paediatric HIV care at 10 selected health facilities in each country, November 2011-February 2012
60
46
95
81
35 3124
6
0
20
40
60
80
100
Lesotho Malawi Zambia Tanzania
Perc
enta
ge (%
)
Trained in PMTCT Trained in paediatric HIV care
STAFF TRAINING ON NEW GUIDELINES
Source: UNICEF and Global Fund. Rapid Assessment of Implementation of 2010 WHO PMTCT Guidelines in Lesotho, Malawi, Tanzania, Zambia, November 2011- February 2012. November 2012
Maternal HIV testing during ANC
Maternal CD4 testing
Early infant HIV testing
Lesotho 9* 6 0
Malawi 10 7 2
Zambia 10 5 0
Tanzania 10 3 2*One urban filter clinic refers patients to another facility for HIV testing
Availability of essential laboratory tests at 10 selected health facilities in each country, November 2011-February 2012
Source: UNICEF and Global Fund. Rapid Assessment of Implementation of 2010 WHO PMTCT Guidelines in Lesotho, Malawi, Tanzania, Zambia, November 2011- February 2012. November 2012
AVAILABILITY OF ON SITE HIV, CD4 & EID TESTING
AZT NVP Cotrimoxazole 3TC TDF Efavirenz
Lesotho 9 10 7 9 10 10
Malawi - 8 9 10* 10* 10*
Zambia 7 7 8 7 _ _
Tanzania 9 9 9 9 _ _
*Available as a one-pill fixed dose combination; -- Those medicines were not assessed given the PMTCT Option
Number of facilities with no stock outs of essential medicines in the past 3 months at 10 selected health facilities in each country, November 2011-February 2012
Source: UNICEF and Global Fund. Rapid Assessment of Implementation of 2010 WHO PMTCT Guidelines in Lesotho, Malawi, Tanzania, Zambia, November 2011- February 2012. November 2012
AVAILABILITY OF ESSENTIAL PMTCT MEDICINES
Maternal HIV testing during ANC
Maternal CD4 testing within one month of HIV
diagnosis*
Maternal ARVs or ART for HIV+ pregnant
women
Lifelong ART coverage for HIV+ pregnant
women
0
20
40
60
80
100 99
68
99
31
79
N/A
71 71
87
66
98
20
62
No data
33
5
Lesotho Malawi Zambia Tanzania
Perc
enta
ge (%
)
Coverage of selected PMTCT servicesPercentage coverage of selected PMTCT services among pregnant and HIV+ women in 10 health facilities in
each country, November 2011-February 2012
Source: UNICEF and Global Fund. Rapid Assessment of Implementation of 2010 WHO PMTCT Guidelines in Lesotho, Malawi, Tanzania, Zambia, November 2011- February 2012. November 2012
Coverage of selected paediatric HIV care services
Percentage coverage of selected paediatric HIV care services among HIV-exposed infants in 10 selected health facilities in each country, November 2011-February 2012
0
20
40
60
80
100 96
5749
93
83 8385
17
45
61
80
58
Zambia Lesotho Malawi Tanzania
Per
cen
tage
(%
)
• Community outreach common practice in all countries via community health workers, volunteers, lay counsellors, mentor mothers or expert patients
• Some involvement of community leaders, traditional healers, use of radio, health campaigns, and use of cell phones for appointment reminders and conveying test results
• Referrals community <-> health facilities often informal, verbal
• Some good examples of formal two-way referrals using forms and accompaniment of clients to health facilities in Malawi and Zambia
Community linkages and referral mechanisms
• Countries were in the process or had not yet adapted registers and monitoring forms to accommodate all of the 2010 WHO PMTCT recommendations
• Data on maternal HIV testing and maternal ARVs during pregnancy were easily available and with well completed registers in both ANC and maternity
• Data on post-natal follow up of HIV+ mothers and exposed infants were often incomplete or unavailable:– CD4 testing, infant HIV testing, cotrimoxazole, infant feeding, postnatal ARVs for PMTCT, and
follow-up care for HIV-exposed infants often lacking or incomplete
• Referral forms exist, but no formal mechanisms of documenting referrals and whether the service was received
• A few facilities improvise registers to capture information considered useful but not in the old registers
• Some partners have separate registers at specific sites they support to collect agency-specific data
Recording keeping and data availability and completeness
• Feasibility, ease of roll out, cost and health benefits were important considerations for adoption of guidelines in all countries
• Implementation of new guidelines requires considerations in:– Strategic planning, adapting and disseminating of new guidelines, along with job
aids to assist health care workers in following new PMTCT protocols.– Capacity development, i.e. training to update and provide new skills and
knowledge to health workers and managers– Ensuring essential logistics and supplies of medicines, laboratory tests and
equipment for all facilities delivering PMTCT interventions.– Strategic shifts e.g. task shifting, decentralization, and supervision and mentoring,
and community engagement (Malawi, Lesotho)– Revision of registers and monitoring tools to incorporate new recommendations
• Safe transport of laboratory samples and results between facilities, district hubs and national testing centres
Summary and Conclusions
• In Malawi, implementation of Option B+ accelerated ART access for HIV+ pregnant women, but not similar effects on paediatric HIV services – e.g. low HIV testing among infants
• Need for family-centred approach as mother’s and children get services from the same place
• Integration of paediatric HIV care into routine MCH services – immunization, community outreach, etc. to optimize access
• Improving longitudinal care for mother-infant pairs until confirmed HIV diagnosis at 18 months is critical regardless of PMTCT option
• Point of care diagnostics is important to minimise loss to follow up, long turnaround time and late initiation of care and treatment
Summary and Conclusions
Limitations• Rapid assessment of initial experiences in the roll out of the
2010 WHO PMTCT guidelines and did not cover all areas of importance
• Timing: national roll-out incomplete, countries in transition from previous guidelines
• Incomplete or lack of data: registers or clinical forms were not updated & referrals for CD4 & EID HIV testing led to long turnaround time for test results causing delays in updating records
• Data abstraction from only 10 facilities per country and hence not comprehensive and representative of the national status; though indicative of coverage
AcknowledgementsUNICEF HQ / ESA Regional OfficeKen LeginsEdward AddaiDorothy Mbori-Ngacha
Global FundAde Fakoya
UNICEF Country OfficesJoyce Mphaya - TanzaniaBlandinah Motaung - LesothoKondwani Ngoma - MalawiSitali Mwasenyeho - Zambia
International consultantsPaula MunderiCarolyn GreenCountry consultantsGivans Ateka – LesothoBellington Vwalika – ZambiaRose Mpembeni – TanzaniaJephter Mwanza – Malawi
National PMTCT Program ManagersMax Bweupe – ZambiaMalisepo Mphale – LesothoDeborah Kajoka – TanzaniaDalitso Midiani - Malawi
91 Key informants – in 4 countries
#PMTCT #AIDSfreegeneration. #4change #AIDS2014