WIKIPATHWAYS ANDHOW TO CHANGE THE

WORLDAlexander Pico Gladstone Institutes San Francisco, CA

10-5107

(OR AT LEAST A SMALL CORNER OF THE WORLD)

WIKIPATHWAYS ANDHOW TO CHANGE THE

WORLDAlexander Pico Gladstone Institutes San Francisco, CA

(OR AT LEAST A SMALL CORNER OF THE WORLD)

10-5100

Gerhard Michal 1974

http://www.wikipathways.org/index.php/Pathway:WP430

http://www.wikipathways.org/index.php/Pathway:WP430

X

http://www.wikipathways.org/index.php/Pathway:WP1601

http://www.wikipathways.org

• XML format (BioPAX)• RESTful web services• HTML embed code• RDF and SPARQL endpoint

http://www.cytoscape.org

ideassynthes

is

data

http://www.wikipathways.org

400

160

80

20122011

20102007

2005

6,200

3,200

20092008

2006

Number of human pathways

Number of unique human genes

320

240

4,700

http://www.wikipathways.org

2,800

1,400

0

20122011

20102009

2008

Over 1 million pageviews by 280,000 unique visitors

~22%

• First unknown user (Jan ’08)• First unknown user (Jan ’08)

• Online (Mar ‘07)

Set Early Milestones Success!

• First unknown user (Jan ’08)• Models

• Communities

• Tools and pipelines

• Publishing models

Don’t Try to Change the World

Work with (not against) established:

• First unknown user (Jan ’08)

• Tweak established models

• Grow communities

• Change perspectives• everyone is a curator• knowledge should be

open

Go Ahead, Change the World

• Tweak established models

• Grow communities

• Change perspectives

Go Ahead, Change the World

• New attribution systems

• redefine “publication”• redefine “productive”

• Tweak established models

• Grow communities

• Change perspectives

• New attribution systems

Go Ahead, Change the World

• New analysis pipelines• connect with other

community-curated resources

New Curation Pipeline

Carlos BellCarroll Gipson

Jill MartinKevin BelangerDaniel Campos

Sarah MorningstarHelen Hayes

Franco B. MuellerAlfred Mohamed

ChrisCharles

Ewan Daviswiki_user:38adeliacurryy

Egon WillighagenDeanne Taylor

Bjoern OestRon Arnold

William HicksBill Roberts

James CarlsonFelix Jensen

Homer PhillipsBetty Grosso

Ezer Serrato QuiñonesErnestina Phillips

Angelbridgette loerte

jasonCarlos Borroto

Jackson GirdlestoneJulia E. Torres

Libby RemlingerElizebeth Espinosa

Emma HalfeyNell Yu

LessMomeyThambaru Wijesekara

Barbar HuieJeremy Slivnick

SailendraBaris

Federica EduatiStephen Houchens

Kerri MoronYuette BealeEmilio GordyJayson BrazilVeola Celaya

Dilshan SumeshkaJude WheelerTyrone Rey

Jacquiline FlorezLarry Parnell

Teresa RzezniczakMagali JaillardPierre NordeenKurt MccrossenHeidi Sheneman

Hester Stekelenburgjun ding

vivivan1988Madhan

Paul Davisvivian1988

Sherlynholiday gclub

Ken YanoBahar Taneri

Alexis Lefebvrefrances

ericwexlerBBQ

James BjorkOG

Babiker Malik OsmanJohn Schmidt

David Winsemiusxiao xiao

Claudio Villanueva Ph.D.Scott Tyler

xuningJuan Diego Rojas

Harm Nijveenanirab naraemily jolly

Iyana Brownemily jollyKathy IveyMary Johnemily jollychristi lea

Danielle Cristina de AlmeidaKenny Wu

Adrien Defayjerome compain

Jenifer Laragideon wackers

GraceWei Xu

muhtadiDror Hilman

LogeayMaya Fox

sdfsaHuashi Ding

pradeep kumar sreenivasaiahYesim Aydin Son

emily jollyMamajasia928RafaelHinkel

chris gillRachel

Jyoti SharmaKaylee

Dr. Renu GoelAlexander

MateuszKasperek112Freya CrawfordJames WilliamsByron CabreraArthur Cromer

Christopher NeelyDanae Harrell

Tawana EcksteinFrank HyltonDavid KempJoel Smith

Amber RichardsJesus CarlsonMike Carter

MmaarrccpPopeeFrancesco Chemello

Frank Frey

jiang liulove

Zephyr López CervillaSudarsanareddy Lokireddy

李隆Jan Krumeich

Maartje LevelsKira FischerDavid Chen

wyq012zy123211897Lucia Ribeiro

Ahmed G. A. AliVictoria

Johann RipfelAshish

Abhishekmezhoud

karim mezhoudErica L. McDermott

luckyzanoSharona Elgavish

Justin PreeceDave Sause

KHALID RASHIDFuat Kurbanov

Madhu NandakumarFerry Jagers

JT. SaitoMark Scott

TzvetanGregory Tombline

Elke DorenbosCarine Oliveira

Glenda Nicioli da Silvavf

Nikhil BhatlaSabine Daemen

Clemens WittwehrIssam El Naqa

Cory BatenchukDe-Cheng Chao

Sara Ibrahimabhishek

TicamufiquJon

LiamFelix Rückert

Maria Pires PachecoRay Andrews II

ramesh airah mae

Lucas SmithNels Nelson

EricZsombor Szőke-Kovács

Anna WieseYasodha

R. NiemansFrederic Schaper

Rianne FijtenMisha Vrolijk

Ferbercamiel hoogendoorn

bart smeetsValin

Carlos J Pirola

Giovanni Dall'OlioStan Gaj

Dexter DuncanLaura van Zon

Lorraine Brennanzhongyuliu

Paolo RomanoRuke Achoja

Neil SwainstonBadrul Yahaya

Doug HoweWilfred J. Poppinga

Fouad Janatjinggao

Björn JohanssonSumihiro

mauro palaSD Englert

sdsadfkatal

Anita BandrowskiRobinbvcx

Andrew Stubbsfdssad

Damariz RiveroSudeshna Das

Jason Rosenzweigfsdfsadfghgfgdewr

Rudolf BlackDaniel Wuttke

Arunweb uggshoeKeith Wagner

chun chentesty

Lou ShaokeHisham EldaiPiet MolenaarNicolas DAVID

MatthewCaroline Miller

AMC Human GeneticsDavid Chen

KarinLieneke SteeghsPatrick KuijpersLoes Jeurissen

pSabrinatommy

Thomas TheelenJohanna

Anne DirkseMichael Rutjens

Samuel SklarLuis

Mettu S Reddywangpeng

Essam SharafDinesh Barupalwangya nqiuChancy Lim

Madeline KoshoPavel Krecek

Jim KaputBrian Caliando

Benjamin SchillerEmily Fox

Theresa BerensSimon DüningTrygve BakkenMarc Gillespie

RobIliana Campillo SachMalcolm Campbell

Georg W. OttoJoerg Bernhardt

Kellie SimsstephenPaul Katz

SLEric StephanCalvin Chan

Yannick Le PriolJanet HigginsClaude Aflalo

PolinaAxel Schwekendiek

Judith M. BoerchendijunRithyaga

vlad ionescuShamith Samarajiwa

JordanChristopher Szeto

An LebacqKatrin SameithVincent Sluijter

Martijn van der BruggenFred Opperdoeshollandorange

Van Anh Huynh-ThuAntony Le Bechec

Hans RoubosKanda Nivesanond

Bertrand De MeulderCaroline Mrejen

Justin Elserpriya ranjan

EamonnKristina

Neerincx APankaj Jaiswal

Philip ZimmermannKevin HermansJonas HummelRalph StrausDavid Theres

NatalieJelena

Charly Johnpalitha dharmawrdhana

Eric H.HarleyJohn W. NewmanLuigi MaioranaLope A. Florez

Robin HawJason Park

Sergey Dmitrievliaoyaojun

Nattha Wannissorn

Thomas KelderMartijn van IerselKristina HanspersMartina Kutmon

Andra WaagmeesterChris Evelo

Bruce Conklin

Susan CoortNathan

SalomonisNick

SantistevanMaintenance

botMichiel

AdriaensKamesh JEd HsiaoNathan J Bowenanne

michielsenmark van grinsven

RishiMiranda Stobbe

Dilyara Yanbaeva

Sander OuburgFrank

DennissenTos TJM

BerendschotAntje Weseler

willemNoortje van der

VorstmitkoMartin

HaagmansAxel Weber

PrabahtGabby KrensPatrick AhlesLars Eijssen

IvarsBen van OmmenSuzan

WopereisHubert Hug

Luna De FerrariRobert

MuetzelfeldtMichael Gribskov

Carsten JäckelJildau

BouwmanDan Bolser

Alipi NaydenovBrent Derry

Michal Galdzicki

Julian PlanaDan Fornika

Yang AnTest User Account

Satya MishraAndrew Gibson

Derek N Robertson

Frank Kolakowski

Mark van der GiezenCannin

Markus HoferSuheeta Roy

Hunter Richards

Jesse PaquetteThaddeus Allen

Hee Jung Chung

Samantha Cooper

Matthias Wabljalyyu

Eva SamalWard

CunninghamPieter

GoossensGR Oliver

Adrian Contreras

wikipathways.org

Acknowledgements

nrnb.org