phlegmasia cerulea dolens - a limb threatening problem · 2019. 10. 28. · venous gangrene...
TRANSCRIPT
![Page 1: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/1.jpg)
Sid Bhende MD
Sentara Vascular
Specialists
April 21st 2017
Phlegmasia Cerulea Dolens - A Limb
Threatening Problem
![Page 2: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/2.jpg)
Presenter name
Title
Date
Disclosures
![Page 3: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/3.jpg)
Presenter name
Title
Date
Complications of DVT
• Early
– Pulmonary Emboli
• Life threatening “saddle embolus”
• Incidence of PE is estimated to be approximately 60 to 70 per 100,000
• PE is found in up to 50% of DVT patients (Silent PE)
![Page 4: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/4.jpg)
Presenter name
Title
Date
![Page 5: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/5.jpg)
Presenter name
Title
Date
Complications of DVT
• Early
– What else?????
Phlegmasia Alba Dolens
Phlegmasia Cerulea Dolens
Venous Gangrene
![Page 6: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/6.jpg)
Presenter name
Title
Date
Complications of DVT
• Late
– PTS (Post Thrombotic Syndrome)
• Leg swelling
• Leg pain
• Skin discoloration
• Varicosities
• Venous ulceration
![Page 7: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/7.jpg)
Presenter name
Title
Date
Early Complications of DVT
Phlegmasia Alba Dolens
Phlegmasia Cerulea Dolens
Venous Gangrene
![Page 8: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/8.jpg)
Presenter name
Title
Date
Plegmasia Alba Dolens
• Phlegmasia “Alba” Dolens
– “Alba” means white (i.e. Albino)
– Referred to as “Milk Leg or White Leg”
– Historically seen in pregnant women (third trimester) or mothers who had just given birth
• Compression of Lt iliac vein against the pelvic rim from an enlarged uterus
– Presently it is due to venous occlusion (DVT)
• 40% of patients with phlegmasia alba dolens have an underlying malignancy
![Page 9: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/9.jpg)
Presenter name
Title
Date
Pathophysiology
• Phlegmasia “Alba” Dolens
– Thrombosis involving ONLY the major deep venous channels but SPARING the collateral veins
– Venous drainage is decreased but still present via the superficial channels
– At this stage the leg is painful, swollen and appears white (pale)
• But no arterial compromise (either palpable or dopplerable pulses)
![Page 10: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/10.jpg)
Presenter name
Title
Date
Pathophysiology
![Page 11: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/11.jpg)
Presenter name
Title
Date
Phlegmasia Alba Dolens
![Page 12: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/12.jpg)
Presenter name
Title
Date
Diagnosis
• Phlegmasia “Alba” Dolens
– Diagnosis is made with venous duplex
• Identify Acute DVT
• Location of DVT (proximal vs distal)
• Extent of DVT
– Contrast enchanced CT scan can be helpful
• To identify thrombus is pelvic veins or IVC
• Check for underlying malignancy
![Page 13: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/13.jpg)
Presenter name
Title
Date
Diagnosis
![Page 14: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/14.jpg)
Presenter name
Title
Date
Treatment • Phlegmasia “Alba” Dolens
– Treatment
• Admit to inpatient
• Anticoagulation (IV heparin gtt)
• Elevate affected limb
• Vascular surgery consultation – Medical management vs. Endovascular venous lysis (CDT, mechanical
thrombectomy, pharmacomechanical thrombectomy)
![Page 15: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/15.jpg)
Presenter name
Title
Date
Phlegmasia Cerulea Dolens • Phlegmasia “Cerulea” Dolens (PCD)
– “Cerulea” means Blue
– Referred to as “Painful Blue Leg”
• Rare condition that occurs in < 1% of DVT patients
• Up to 90% of patients with PCD have underlying malignancy (50% occult malignancy)
![Page 16: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/16.jpg)
Presenter name
Title
Date
Phlegmasia Cerulea Dolens • 50% of patients with PCD progress to Venous
Gangrene
– 30-50% Limb Amputation rate
– Overall Mortality rate of 20-40%
![Page 17: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/17.jpg)
Presenter name
Title
Date
Pathophysiology • Phlegmasia “Cerulea” Dolens
– Thrombosis causing COMPLETE occlusion of venous drainage (deep and superficial system)
– Leads to increase in capillary pressure
– Leads to exudation of fluid into the interstitial space
– Leads to skin blistering
• Characteristics of PCD
– Pain, swelling and most importantly cyanosis “blue appearance”
![Page 18: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/18.jpg)
Presenter name
Title
Date
Pathophysiology
![Page 19: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/19.jpg)
Presenter name
Title
Date
Pathophysiology
![Page 20: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/20.jpg)
Presenter name
Title
Date
![Page 21: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/21.jpg)
Presenter name
Title
Date
Diagnosis • Phlegmasia “Cerulea” Dolens
– Based on clinical signs and symptoms
• Painful, blue, swollen leg
– Venous duplex to confirm the diagnosis and localize the thrombus (purpose of intervention)
– Contrast enchanced CT to identify centrally located and pelvic thrombus
![Page 22: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/22.jpg)
Presenter name
Title
Date
Plegmasia Cerulea Dolens
![Page 23: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/23.jpg)
Presenter name
Title
Date
Treatment • Phlegmasia “Cerulea” Dolens
– THIS IS AN EMERGENCY!!
– PATIENT IS GOING TO THE OR FOR SURGICAL VENOUS THROMBECTOMY
– Fluid resuscitation
• Patients are hypotensive and sometimes in shock due to fluid extravasation and loss of intravascular fluid
– Anticoagulation
• IV heparin bolus prior to OR
![Page 24: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/24.jpg)
Presenter name
Title
Date
Treatment • Phlegmasia “Cerulea” Dolens
– Systemic tPA vs Catheter directed thrombolysis
• Literature does not support either therapy as being successful
• Time is tissue
– Some surgeons recommend a brief (6 hours) of IV heparin gtt with profound leg elevation
• If unsuccessful then will proceed with surgical venous thrombectomy
![Page 25: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/25.jpg)
Presenter name
Title
Date
Surgical Treatment • Phlegmasia “Cerulea” Dolens
– Local, Regional or General anesthesia
– Longitudinal groin incision to expose CFV, GSV and SFA
– IV Heparin intra op if not given preop (Check ACT)
– Venotomy to facilitate Fogarty catheter thrombectomy
• American surgeons – place IVC filter (contralateral groin) before
• European surgeons – no filter, perform thrombectomy with positive pressure ventilation or Valsalva maneuver
![Page 26: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/26.jpg)
Presenter name
Title
Date
Surgical Treatment
![Page 27: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/27.jpg)
Presenter name
Title
Date
Surgical Treatment
![Page 28: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/28.jpg)
Presenter name
Title
Date
Surgical Treatment • Phlegmasia “Cerulea” Dolens
– Place Fogarty balloon in Common Iliac vein
– Pass suction catheter parallel to Fogarty and try to suction out the internal iliac vein thrombus
– Must confirm iliac vein flow
• MANDATORY VENOGRAM
– If Iliac vein stenosis/compression (MTS) is noted then may need balloon angioplasty + stenting
![Page 29: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/29.jpg)
Presenter name
Title
Date
Surgical Treatment
![Page 30: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/30.jpg)
Presenter name
Title
Date
Surgical Treatment • Phlegmasia “Cerulea” Dolens
– Thrombus in infrainguinal region is expressed manually using an Esmarch
– Start wrapping at the base of the toes and proceed proximally to the groin incision
• Passing fogarty distally will damage venous valves
![Page 31: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/31.jpg)
Presenter name
Title
Date
Surgical Treatment
![Page 32: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/32.jpg)
Presenter name
Title
Date
Surgical Treatment • Phlegmasia “Cerulea” Dolens
– Once the venous outflow is restored the venotomy is closed
– An autogenous AVF is created in groin to increase iliac vein patency
• GSV is divided and proximal end is anastomosed to SFA
– Perform a 4 compartment lower leg fasciotomy
![Page 33: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/33.jpg)
Presenter name
Title
Date
Surgical Treatment
![Page 34: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/34.jpg)
Presenter name
Title
Date
Surgical Treatment
![Page 35: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/35.jpg)
Presenter name
Title
Date
Surgical Treatment • Phlegmasia “Cerulea” Dolens
– What if there is thrombus extending into the IVC?
• Transperitoneal incision
• Expose IVC below renal veins to bifurcation
• IVC is opened and the thrombus is removed
![Page 36: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/36.jpg)
Presenter name
Title
Date
Post Operative Treatment • Phlegmasia “Cerulea” Dolens
– Continue IV heparin drip x 5 days
– Then transition to oral anticoagulation (coumadin, xarelto, eliquis) x 6 months
– Gradient Compression Stockings
– Once swelling decreased, return to OR to close fasciotomy sites or heal with secondary intention
– Ligate groin AVF in 6-12 weeks
![Page 37: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/37.jpg)
Presenter name
Title
Date
Venous Gangrene • Venous Gangrene
– Massive iliofemoral or IVC occlusion with extensive vascular congestion and venous ischemia
– Thrombosis causing COMPLETE occlusion of venous drainage (deep and superficial system) AND ARTERIAL COMPROMISE
– 50% of phlegmasia cerulea dolens progress to venous gangrene
![Page 38: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/38.jpg)
Presenter name
Title
Date
Pathophysiology
![Page 39: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/39.jpg)
Presenter name
Title
Date
Venous Gangrene • Clinical Features
– Excruciating Limb pain
– Severe edema
– Blistering with fluid extravasation
– Superficial gangrene and necrosis
– No motor or sensory to foot
– IRREVERSIBLE (Phlegmasia Alba and Cerulea Dolens are reversible)
– Treatment is AMPUTATION
![Page 40: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/40.jpg)
Presenter name
Title
Date
Venous Gangrene
![Page 41: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/41.jpg)
Presenter name
Title
Date
Case Study • 75 year old male presents to ED with LLE pain and
swelling x 1 day
• Denies CP or SOB
• Pt recently diagnosed with Stage IV Lung cancer and received 2 doses of chemotherapy via a mediport
• Vital signs are stable
• O/E – LLE is edematous but NO PHLEGMASIA, Pedal pulses are palpable
![Page 42: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/42.jpg)
Presenter name
Title
Date
Case Study • Blood work is normal
• LLE venous duplex to r/o DVT
• Venous duplex demonstrated acute femoropopliteal and tibial occlusive DVT, no extension into external iliac vein
![Page 43: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/43.jpg)
Presenter name
Title
Date
Case Study
![Page 44: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/44.jpg)
Presenter name
Title
Date
Case Study • What do you do?
• Patient was discharged from ED with Xarelto (starter pack) x 21 days
• Instructed to follow up with vascular surgery in the next week
• Keep LLE elevated
![Page 45: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/45.jpg)
Presenter name
Title
Date
Case Study • Patient returns to ED 2 days later complaining of
worsening pain and swelling
• A different ED physician evaluates patient
• O/E – LLE is much more swollen and appears white
• Repeat LLE venous duplex is ordered and now demonstrates Acute Left external iliac vein, femoral vein, popliteal vein and tibial vein DVT
• Vascular surgery consult obtained
![Page 46: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/46.jpg)
Presenter name
Title
Date
Case Study • Vascular surgery evaluates patient and feels that
patient has developed Phlegmasia Alba Dolens
• Pt is admitted to ICU
• Initiate IV heparin gtt
• CT A/P with contrast to better evaluate IVC and pelvic veins
• Keep LLE elevated
![Page 47: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/47.jpg)
Presenter name
Title
Date
Case Study • No IVC clot
• Clot extends to the Lt CIV
![Page 48: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/48.jpg)
Presenter name
Title
Date
Case Study • Discuss options of medical management (IV Heparin
vs. Endovascular thrombolysis/thrombectomy)
– Risk of bleeding from venous lysis is high due to stage IV lung cancer
• Decision made to continue IV heparin and perform serial exams with the understanding that if this progress to phlegmasia cerulean dolens then patient will need surgery
![Page 49: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/49.jpg)
Presenter name
Title
Date
Case Study • Next morning the LLE pain is worse and now has
spots of bluish purplish areas (new)
![Page 50: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/50.jpg)
Presenter name
Title
Date
Case Study • Pt taken to OR for surgical venous thrombectomy
– Able to clear iliac vein clot
– Venogram was normal
– Able to express infrainguinal clot
– AVF created in left groin
– LLE prophylactic fasciotomy performed
• Post op patient continued on IV heparin gtt
![Page 51: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/51.jpg)
Presenter name
Title
Date
Case Study • Over the course of next few days, the LLE swelling,
pain and color improved
• Fasciotomy sites closed on POD #4
• Pt given GCS
• Discharged on coumadin x 6 months
![Page 52: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/52.jpg)
Presenter name
Title
Date
Take Home Points • Phlegmasia “Alba” Dolens – “White” leg
– Medical management (IV Heparin) vs Endovascular therapy
– Check for Malignancy (40%)
• Phlegmasia “Cerulea” Dolens – “Blue” leg
– Limb threatening emergency
– Mandatory open intervention
– Check for Malignancy (90%)
![Page 53: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/53.jpg)
Presenter name
Title
Date
Take Home Points • Venous Gangrene – “Game Over”
– Amputation
![Page 54: Phlegmasia Cerulea Dolens - A Limb Threatening Problem · 2019. 10. 28. · Venous Gangrene •Venous Gangrene –Massive iliofemoral or IVC occlusion with extensive ... •Pt recently](https://reader035.vdocuments.us/reader035/viewer/2022071510/612e56e31ecc51586942c048/html5/thumbnails/54.jpg)
Presenter name
Title
Date
Thank You