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Old University Archivio Antico Palazzo del Bo

Via 8 Febbraio, 2 - 35122 Padova

University of Padua

PhD Courses Medical and Biomedical Sciences

Thursday, June 28, 2018

Organized by Prof.ssa Annalisa Angelini Department of Cardiac, Thoracic and Vascular Sciences

In collaboration with: Alessandra Cervellin Department of Cardiac, Thoracic and Vascular Sciences Tel 049/8272288 – Fax 049/8272294 e-mail: alessandra.cervellin@unipd.it

A.R.C.A. Associazione Ricerche Cardiopatie Aritmiche Via A. Gabelli, 86 35121 Padova

sito web: http://www.arca-cuore.it/

8.45 OPENING CEREMONY

9.00 ARCHIVIO ANTICO

Chairperson: Prof. Carlo Giaquinto

A R C H I V I O

A N T I C O

A R C H I V I O

ONCOHEMATOLOGY, MEDICAL GENETICS, RARE DISEASES AND

PREDICTIVE MEDICINE

Giulia BORELLA – Tutor: Dr. Martina PIGAZZI

“THE ROLE OF BONE MARROW NICHE IN THE PEDIATRIC ACUTE MYELOID LEUKEMIA: CREATION OF 3D IN VITRO CULTURES AND PDX MODELS”

Marco DAVERIO – Tutors: Dr. Angela AMIGONI/Prof. Liviana DA DALT

“THE USE OF DEXMEDETOMIDINE FOR PROLONGED SEDATION IN CHILDREN ADMITTED TO PEDIATRIC INTENSIVE CARE UNIT”

Michele GRASSI – Tutor: Prof. Maurizio MURACA

“EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STEM/STROMAL CELLS AS TOOL FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE”

Elena PRIANTE – Tutors: Prof. Eugenio BARALDI/Dr.ssa Giovanna VERLATO

“METABOLOMIC PROFILE IN PRETERM NEWBORNS: ASSOCIATION WITH MATERNAL METABOLIC STATUS, GROWTH PATTERN AND DIFFERENT NUTRITIONAL REGIMEN”

Francesca SENSI – Tutor: Prof. Gianni BISOGNO

“DECELLULARIZED COLORECTAL CANCER MATRIX AS A BIOACTIVE IN VITRO 3D MODEL FOR CANCER RESEARCH AND DRUG SCREENING”

A R C H I V I O

HEALTH PLANNING SCIENCES

Marianna RUSSO – Tutors: Prof. Prof. Paola FACCHIN, Prof. Anna APRILE, Dr. Melissa ROSA-RIZZOTTO

“A PROPOSAL FOR A DECISION-MAKING MODEL FOR CLINICAL SUBSTANTIATION OF CHILD SEXUAL ABUSE: STUDY-DESIGN”

10.00 ARCHIVIO ANTICO

Chairperson: Prof. Annalisa Angelini

A R C H I V I O

A N T I C O

A R C H I V I

CARDIOTHORACIC AND VASCULAR SCIENCES

Davide BIONDINI – Tutor: Prof. Marina SAETTA “RAPID AND SLOW PROGRESSORS IN IDIOPATHIC PULMONARY FIBROSIS:TWO DIFFERENT PHENOTYPES WITH DIFFERENT RESPONSE TO TREATMENT”

Anna DI BONA – Tutors: Prof. Cristina BASSO, Dr. Tania ZAGLIA

“GENERATION AND PHENOTYPING OF A NOVEL KNOCK-IN MOUSE MODEL OF ARRHYTHMOGENIC CARDIOMYOPATHY (AC)”

Luca NAI FOVINO – Tutor: Prof. Giuseppe TARANTINI

“UNMASKING MYOCARDIAL BRIDGE-RELATED ISCHEMIA BY INTRACORONARY FUNCTIONAL EVALUATION”

Stefania Edith VULJAN – Tutor: Prof. Fiorella CALABRESE

“IDIOPATHIC PULMONARY FIBROSIS (IPF): TISSUE IDENTIFICATION OF CRUCIAL BIOMARKERS WITH OMICS TECHNIQUES”

ENDOCRINE AND METABOLIC SCIENCES

Nino Cristiano CHILELLI – Tutor: Prof. Annunziata LAPOLLA

“AGES ACCUMULATION IN ADIPOCYTES IMPAIRS GLUCOSE

O

A R C H I V

UPTAKE THROUGH POSSIBLE POST-TRANSLATIONAL MODIFICATIONS OF GLUT4: AN INNOVATIVE IN VITRO LONG-TERM GLYCATION APPROACH”

Alessandra GIANNELLA – Tutor: Prof. Angelo AVOGARO

“SHORT NONCODING RNAS CHARACTERIZATION IN PLASMA FROM TYPE 1 DIABETIC PATIENTS BY NEXT GENERATION SEQUENCING”

11.00 COFFEE BREAK

11.30 ARCHIVIO ANTICO

Chairperson: Prof. Annalisa Angelini

A R C H I V I O

A N T I C O A R

BIOSTATISTICS AND CLINICAL EPIDEMIOLOGY

Corrado LANERA – Tutor: Prof. Dario GREGORI

“USE OF MACHINE LEARNING TECHNIQUES TO CLASSIFY UNSTRUCTURED TEXT-BASED CLINICAL DATA: A CASE STUDY ON PEDIATRIC EMERGENCY DEPARTMENT RECORDS IN NICARAGUA”

NEUROSCIENCE

Silvia FACCHINI – Tutor: Prof. Carlo SEMENZA, Prof. Maurizio CORBETTA

“COGNITIVE OUTCOME OF PATIENTS WITH BRAIN TUMOR: PRELIMINARY DATA OF A LONGITUDINAL STUDY”

Aurora FUSTO – Tutor: Prof. Elena PEGORARO

“NETOSIS IN DUCHENNE MUSCULAR DYSTROPHY”

Valeria MORBIDONI – Tutor: Dr. Eva TREVISSON

“C. ELEGANS COME MODELLO DI MALATTIE NEUROMETABOLICHE”

Marco PUTHENPARAMPIL – Tutor: Prof. Elena PEGORARO

C H I V

“PERIPHERAL IMBALANCED TFH/TFR RATIO CORRELATES WITH INTRATHECAL IGG SYNTHESIS IN MULTIPLE SCLEROSIS AT CLINICAL ONSET”

12.20 ARCHIVIO ANTICO

Chairperson: Prof. Paola Zanovello

A R C H I V I O

A N T I C O A R C H I

CLINICAL AND EXPERIMENTAL ONCOLOGY AND IMMUNOLOGY

Deborah BONGIOVANNI – Tutor: Dr. Erich PIOVAN

“THERAPEUTIC TARGETING OF HEDGEHOG SIGNALING PATHWAY IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA”

Halenya MONTICELLI – Tutors: Prof. Simone MOCELLIN

“ROLE OF MITCA2+ HOMEOSTASIS IN BREAST CANCER”

Marco TONELLO – Tutor: Prof. S. PUCCIARELLI / Dr. P. PILATI

“IMMUNOPHENOTYPICAL CHARACTERIZATION OF COLORECTAL CANCER METASTASIS FROM PRE-TREATED VS CHEMO-NAIVE PATIENTS”

Cristina VICENZETTO – Tutor: Prof. Gianpietro SEMENZATO

“CCL5/IL-6 LOOP SUSTAINS PRO-INFLAMMATORY MICROENVIROMENT IN A SUBSET OF T-LARGE GRANULAR LYMPHOCYTE LEUKEMIA PATIENTS”

Andrea VISENTIN – Tutor: Dr. Francesco PIAZZA

“CK2A IS OVEREXPRESSED, ACTIVE AND TARGETABLE WITH SILMITASERTIB IN CLASSICAL HODGKIN LYMPHOMA”

13.10 LUNCH

14.00 ARCHIVIO ANTICO Chairperson: Prof. Stefano Piccolo

A R C H I V I O

A N T I C O

A R C H I V I O

A N T I C

BIOMEDICINE

Laura GIRARDI – Tutor: Prof. Stefano PICCOLO, Dr.ssa C. PATASSINI

“NEXT-GENERATION SEQUENCING (NGS) FOR PREIMPLANTATION GENETIC TEST FOR CHROMOSOMAL ANEUPLOIDIES (PGT-A): VALIDATION AND IMPLEMENTATION OF THE ION REPROSEQ PGT-A PROTOCOL AND COMPARISON WITH REAL-TIME QPCR”

Romy LUCON XICCATO– Tutor: Prof. Stefano PICCOLO

“ESTABLISHMENT OF HUMAN CCA ORGANOID CULTURE” Valeria MARIOTTI – Tutor: Prof. Stefano PICCOLO

“VEGF-A/NOTCH SIGNALING IN THE REGULATION OF VEGFR2 EXPRESSION IN BILIARY CELLS”

Maria Vittoria SALVATI – Tutor: Dr. Cristiano SALATA

“EVALUATION OF HAZARA VIRUS INFECTION IN TICK CELL LINES AS A MODEL TO STUDY THE PERSISTENT INFECTION OF CRIMEAN-CONGO HAEMORRHAGIC FEVER VIRUS IN TICKS”

Paola SOLDA’ – Tutor: Prof. Sara RICHTER

“G-QUADRUPLEXES IN THE HIV-1 LTR PROMOTER REGION: IMPLICATION IN REGULATING VIRAL LATENCY”

Stefania VOGIATZIS – Tutor: Prof. Arianna CALISTRI

“DEVELOPMENT AND VALIDATION OF CHIMERIC NEDD4 UBIQUITIN LIGASE SPECIFICALLY TARGETING ALPHA-SYNUCLEIN AS AN INNOVATIVE THERAPEUTIC APPROACH FOR PARKINSON’S DISEASE”

Ana-Marija VUCKOVIC– Tutor: Prof. Fulvio URSINI

“AEROBIC METABOLISM LINKS LIPID PEROXIDATION TO CELL DEATH”

O

A R C H I V I O

A N T I C O

A R C H I V I O

Daniela ZAGO – Tutor: Prof. Saverio Giuseppe PARISI

“THE SWITCH OF KLEBSIELLA PNEUMONIAE PRODUCING CARBAPENEMASES FROM COLISTIN-SENSITIVE TO COLISTIN-RESISTANCE: THE EXPERIENCE OF PADOVA TEACHING HOSPITAL”

REGENERATIVE MEDICINE

Irene BRIAN – Tutor: Prof. Sirio DUPONT

“MECHANOTRASDUCTION AND CELLULAR METABOLISM”

Marika CRESCENZI – Tutor: Dr. Francesco Paolo RUSSO

“DIMORPHISM IN FIBROSIS DYNAMICS IN A MURINE MODEL OF CHRONIC HEPATIC INJURY”

Silvia RICCETTI – Tutor: Prof. Luisa BARZON

“IN VITRO MODELING OF PATIENT-SPECIFIC SUSCEPTIBILITY TO FLAVIVIRUSES INFECTION BY USING INDUCED PLURIPOTENT STEM CELLS”

Valentina TONELOTTO – Tutor: Prof. Stefano PICCOLO

“ZEBRAFISH AS A MODEL FOR DISSECTING THE MECHANISMS INVOLVED IN COLLAGEN VI FUNCTIONS DURING EMBRYONIC AND POSTNATAL DEVELOPMENT”

Irene ZORZAN – Tutor: Prof. Graziano MARTELLO

“DISSECTING THE ROLE OF TGFβ PATHWAY IN THE PLURIPOTENCY NETWORK”

16.10 COFFEE BREAK

16.30 ARCHIVIO ANTICO

Chairperson: Prof. Piero Maestrelli

A R C H I V I O

ANT

MOLECULAR AND CELLULAR PHARMACOLOGY

Yahima FRION HERRERA – Tutor: Prof. Maria CARRARA

“CHEMOSENSITIZING PROPERTIES OF CUBAN PROPOLIS AND NEMOROSONE IN DRUG-RESISTANT HUMAN COLON CARCINOMA CELLS”

PHARMACOLOGICAL, TOXICOLOGY AND THERAPY

Silvia CERANTOLA – Tutor: Dr. Maria Cecilia GIRON

“ABSTRACTINVOLVEMENT OF TOLL-LIKE RECEPTOR 4 ON SMALL INTESTINE NEUROMUSCULAR DYSFUNCTIONS IN A MOUSE MODEL OF HIGH-FAT DIET-INDUCED OBESITY”

16.50 ARCHIVIO ANTICO Chairperson: Prof. Paolo Angeli

A R C H I V I O

A N T I C O

RHEUMATOLOGICAL AND GERIATRIC SCIENCES

Mariele GATTO – Tutor: Prof. Andrea DORIA

“DECREASED CIRCULATING PTX3-SPECIFIC B CELLS ARE ASSOCIATED WITH ACTIVE LUPUS NEPHRITIS”

Erika PIGATTO – Tutor: Prof. Franco COZZI - Prof. Paolo SFRISO

“GASTROINTESTINAL INVOLVEMENT IN SYSTEMIC SCLEROSIS: PATHOGENETIC ROLE OF GUT MICROBIOME AND ADIPOKINES”

HEMATOLOGICAL AND GERIATRIC SCIENCES

Irene DI PASQUALE – Tutor: Prof. Fabrizio FABRIS

“LINK BETWEEN VON WILLEBRAND FACTOR MULTIMERS, RELAPSES AND CORONARY MICROCIRCULATION IN PATIENTS

A R C H I V I O

A N T

WITH THROMBOTIC THROMBOCYTOPENIC PURPURA IN REMISSION”

HEPATOLOGICAL AND TRANSPLANTATION SCIENCES

Alessandra BERTACCO – Tutor: Prof. Umberto CILLO

“VIDEOLAPAROSCOPIC MICROWAVE ABLATION AT A EUROPEAN HIGH-VOLUME CENTER: SAFETY, EFFICACY AND RECURRENCE PROFILE OF 815 PROCEDURES”

Antonietta ROMANO – Tutor: Prof. Paolo ANGELI “NEWLY DIAGNOSED HEPATOCELLULAR CARCINOMA IN PATIENTS WITH ADVANCED HEPATITIS C TREATED WITH DAAS: A PROSPECTIVE POPULATION STUDY”

17.40 ARCHIVIO ANTICO Chairperson: Prof. Paolo Bernardi

A R C H I V I O

A N T I C O

BIOMEDICAL SCIENCE

Gaia BUTERA – Tutor: Prof. Anna RAFFAELLO

“MITOCHONDRIAL ADAPTATION ON PARVALBUMIN KNOCKOUT MUSCLE FIBERS”

Caterina TEZZE – Tutor: Prof. Marco SANDRI

“OPA1 ORCHESTRATES PRECOCIOUS SENESCENCE, DEGENERATION OF MULTIPLE ORGANS AND PREMATURE DEATH THROUGHT INFLAMMATION AND METABOLIC CHANGES”

Carmen TROIANO – Tutor: Prof. Fabio DI LISA

“O-GLCNACYLATION OF F-ATP SYNTHASE IN RELATION TO MITOCHONDRIAL ROS FORMATION, DIABETES, AND PTP OPENING”

18.10 CLOSING REMARKS

PHD COURSES (XXXII CYCLES)

1.

BIOMEDICAL SCIENCE Coordinator: Professor Paolo BERNARDI

2.

CLINICAL AND EXPERIMENTAL ONCOLOGY AND IMMUNOLOGY Coordinator: Professor Paola ZANOVELLO

3.

CLINICAL AND EXPERIMENTAL SCIENCES Coordinator: Professor Paolo ANGELI Curriculum: Clinical Methodology, Medicine of Physical Exercise,

Diabetic, Endocrinological and Nephrological Sciences Rheumatological and Laboratory Sciences Hematological and Geriatric Sciences Hepatology and Transplantation Sciences

4.

DEVELOPMENTAL MEDICINE AND HEALTH PLANNING SCIENCES Coordinator: Professor Carlo GIAQUINTO Curriculum: Oncohematology, Medical Genetics, Rare Diseases and

Predictive Medicine Health Planning Sciences

PHD COURSES (XXXII CYCLES)

5.

MOLECULAR MEDICINE Coordinator: Professor Stefano PICCOLO Curriculum: Biomedicine Regenerative Medicine

6.

PHARMACOLOGICAL SCIENCES Coordinator: Professor Piero MAESTRELLI Curriculum: Molecular and Cellular Pharmacology Pharmacology, Toxicology and Therapy

7.

TRANSLATIONAL SPECIALISTIC MEDICINE “G.B. MORGAGNI” Coordinator: Professor Annalisa Angelini Curriculum: Cardiothoracic and Vascular Sciences Endocrine and Metabolic Sciences Neuroscience