Pharmacology of neurotransmitters

MCQs SAQs summury

:قادة فريق علم األدوية

عبدالرحمن ذكري &لي التميمي : الشكر موصول ألعضاء الفريق املتميزين

جواهر اخليال

شذا الغيهب روان سعد القحطاني

@pharma436pharma436@outlook.com

Kindlychecktheeditingfilebeforestudyingthisdocumenthttps://docs.google.com/presentation/d/1_-g1vol4eBWPet5xVCkuTGFvvnhFF3PJmU0tWtEEw_o/edit?usp=sharing

Yourfeedback: https://docs.google.com/forms/d/1sxDqHtpP3bUaOhQmYw96IE7mX-DlrklT5dlZUA2teSI/edit

DiseasesthatareinfluencedFunctionNT• Damagetocholinergicreceptors isassociatedwith

memorydeficitsasinAlzheimer'sdisease.• Muscarinicantagonistsashyoscinecauseamnesia• IncreasedbrainlevelofAchpredisposeto

Parkinson'sdisease• Schizophreniamaybeduetoimbalancebetween

Ach&dopaminebrainlevels.• Depressionmaybeamanifestationofacentral

cholinergicpredominance.

• Achfunctionsasaneuro-modulatorwhichaltersthewayotherbrainstructuresprocessinformation.

• Achisbothexcitatoryandinhibitory.• Achisthoughttobeinvolvedincognitivefunctions

suchas:Ø MemoryØ ArousalØ Attention

Acetylcholine

AmeliorateSchizophreniaParkinson’sdiseaseDepressionDrugaddictionAttentiondeficithyperactivitydisorder*

• Dopaminehas4pathwaytosynapseinandgive itsaction :

1- Inchemoreceptortriggerzone(CTZ)à (Antiemeticeffect)2- Inmesolimbicsystemà(psychiatriceffect)3- Innigrostriatalsystem(basalganglia)à (neurologiceffect)4- Intuberoinfundibularpathway(leadtoHyperprolactinemia)à (endocrinaleffect)

Dopa

mine

AvarietyofmedicallyimportantdrugsworkbyalteringtheactionsofNEe.g.,fortreatmentofCVproblemsandsomeofpsychiatricconditions.• Mooddisorders:

highNEàManiaNElowàDepression

It isacatecholaminealsocalled noradrenalinethedirectprecursorofNEisdopamineTheCNSeffectsofNEaremanifestedin:Ø AlertnessØ arousalØ readinessforaction.

Norepine

phrin

e

Modulationofserotoninatsynapsesisamajoractionofegantidepressantsseveralclassesof

selectiveserotoninre-uptakeinhibitors(SSRIs).

Schizophrenia ,VomitingGeneralizedanxiety,SocialphobiaObsessivecompulsivedisorders

5-hydroxytryptamine (5-HT)isamonoamine.

PrimarilyfoundintheCNS,GIT,platelets.

Itisapopularthoughtthatserotoninisresponsibleforfeelingofwell-being&happiness.

Itplaysanimportantrole:inregulationofMood,sleep,appetiteandpainperception.andsomecognitivefunctions,includingmemoryandlearning.

Serotonin

(5-HT)

DecreaseGABAbraincontentisassociatedwith:EpilepsyAnxietyConvulsionsInsomniaBenzodiazepine(diazepam)enhancesGABAfunctionandusedintreatmentofabovediseases

• GABAisthe maininhibitoryinthebrain• Presentthroughoutthebrain.• thereisverylittleinperipheraltissuesGA

BA

• Reductionofbraindamagefollowing:• strokes&headinjury• Drugdependence, Schizophrenia• Treatmentofepilepsy

• excitatoryneurotransmitter• increaseinitslevelpredisposetoepilepsy

Glutam

ate

Answer:

1)B

2)C

3)C

4)A

5)C

6)C

7)A

1- ApatientdiagnosedwithEpilepsy,whichofthefollowingdrugsisthebestinhiscase?

A)Levodopa.B)diazepam.C)Risperidone.

2- Whichofthefollowingtransmitterpredominantlyinvolvedinpsychosis?

A) serotonin.B)norepinephrine.C)dopamine.

3- Whichofthefollowingtransmitterpredominantlyinvolvedinpsychosis?

A)serotonin.B)norepinephrine. C)glutamate.

4- A35yearoldfemalewithschizophreniacometothecliniccomplainingfromlatepregnancy.Aanalysistestwaspreformedandthedoctorfoundelevatedlevelofprolactin.Whichofthefollowingdrugcausesuchsideeffect?A)dopaminergicdrugs.B)anticholinergicdrugs.C)glutamateantagonistsdrugs.

5- Whichofthefollowingtransmitterplayanimportantroleinmemoryandlearning?A)Serotonin.B)Dopamine.C)Acetylcholine.

6- WhichofthefollowingtransmitterpredominantlyinvolvedinAlzheimer'sdisease?A)Serotonin.B)Dopamine.C)Acetylcholine.

7- WhichofthefollowingtransmitterpredominantlyinvolvedinObsessivecompulsivedisorders?A)Serotonin.B)Dopamine.C)Acetylcholine.

A29yearoldMalepatientcametothecliniccomplainingofinsomniaandchanginginhismood,Healsomentionedlossofappetiteforthelastfewweeks.1- What’stheneurotransmitterthatismostlikelydisturbedinit’slevel?

Serotonin2-Where’sthisneurotransmitterusuallyfound?

CNS,GIT,platelets3- listsomeotherdisordersthatareinfluencedbychangesin thisneurotransmitter?

Obsessivecompulsivedisorders,Schizophrenia,Depression,Generalizedanxiety,Socialphobiaandvomiting

8- WhichofthefollowingtransmitterpredominantlyinvolvedinEpilepsy?

A)Glutamicacid.B)GABA.C)Both.

9- Whichofthefollowingstatementcorrectaboutacetylcholine?A)ItisthemaininhibitoryneurotransmittersB)Itisneuromodulator.C)HasnoroleinParkinson'sdisease.

10- A36malehasaheadinjuryduetocaraccident,ifhedevelopabrainstrokelater,WhichofthefollowingneurotransmittersmayReducethebraindamage?A)dopamineB)Glutamicacid.C)GABA

Answer:

8)C

9)B

10)B