Pharmacology and Therapeutics Publications 2008 Alaoui-Jamali, Moulay (See Department of Medicine) Allen, Bruce Xiao L, Coutu P, Villeneuve LR, Tadevosyan A, Maguy A, Le Bouter S, Allen BG, Nattel S (2008) Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res. 103(7):733-42. Boivin B, Vaniotis G, Allen BG, Hébert TE (2008) G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm? J Recept Signal Transduct Res. 28(1-2):15-28. Farhat N, Matouk CC, Mamarbachi AM, Marsden PA, Allen BG, Thorin E (2008) Activation of ETB receptors regulates the abundance of ET-1 mRNA in vascular endothelial cells. Br J Pharmacol. 153(7):1420-31. Almazan, Guillermina Hemdan S, Almazan G (2008) Dopamine-induced toxicity is synergistically potentiated by simultaneous HSP-90 and Akt inhibition in oligodendrocyte progenitors. J. Neurochem. 105:1223-1234. Batist, Gerald (See Department of Oncology) Bernard, Daniel Lamba P, Khivansara V, Santos M, Bernard DJ (2008) Paired-like homeodomain transcription factors 1 and 2 regulate follicle stimulating hormone β-subunit transcription through a conserved cis-element. Endocrinology. 14 (6):3095-108. Lamba P, Hjalt TA, Bernard DJ (2008) Novel forms of Paired-like homeodomain transcription factor 2 (PITX2): Generation by alternative translation initiation and mRNA splicing. BMC-Molecular Biology. 9:31. Wang Y, Fortin J, Lamba P, Bonomi M, Persani L, Roberson MS, Bernard DJ (2008) AP-1 and Smad proteins synergistically regulate human follicle-stimulating hormone β subunit promoter activity. Endocrinology. 149(11):5577-91. Robakis T, Bak B, Lin S-H, Bernard DJ, Scheiffele P (2008) An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin-domain protein. J Biol Chem. 283(52):36369-76. Bowie, Derek Fay AML, Corbeil, CR, Brown P, Moitessier N, Bowie D (2008) Functional characterization and in silico docking of full and partial agonists acting on GluK2 kainate receptors. Mol. Pharmacology. 75, 1096-1107.

Pharmacology and Therapeutics Publications 2008 Zhao B, Wong AYC, Murshid A, Bowie D, Presley J, Bedford FK (2008) Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis. Cellular Signaling. 10, 1769-1779. Bowie D (2008) Ionotropic glutamate receptors & CNS disorders. Invited review for CNS & Neurological Disorders - Drug Targets. 7, 129-143. Osswald IK, Galan A, McKinney RA, Bowie D (2008) Expression of novel Ca2+ permeable AMPA receptors in the developing retina is triggered by neurotrophins. Canadian Association for Neurosciences. May 2008 MacLean DM, Galan A, Osswald IK, Bowie D (2008) Functionally distinct calciumpermeable AMPA receptors are expressed in the hippocampus and cerebellum. Canadian Association for Neurosciences. May 2008 Čapek, Radan Han L, McCusker J, Cole M, Abrahamowicz M, Čapek R (2008) 12-month cognitive outcomes of major and minor depression in older medical patients. Amer. J. Geriatr. Psychiatry. 16:742-751. Chemtob, Sylvain Yang C, Mwaikambo B, Zhu T, Gagnon C, Seshadri S, Lachapelle P, Lavoie JC, Chemtob S, Hardy P (2008) Lymphocytic microparticles inhibit angiogenesis by stimulating oxidative stress and negatively regulating VEGF-induced pathways, Am J Physiol. 294:R467-476. Quiniou C, Sapieha P, Lahaie I, Hou X, Brault S, Beauchamp M, Leduc M, Rihakova L, Joyal JS, Nadeau S, Heveker N, Lubell W, Sennlaub F, Gobeil F Jr, Miller G, Pshezhetsky AV, Chemtob S (2008) Characterization of a novel noncompetitive antagonist of IL-1 receptor. J Immunol. 180:6977-6987. Kooli A, Kermorvant-Duchemin E, Sennlaub F, Bossolasco M, Hou X, Honoré JC, Dennery PA, Sapieha P, Varma DR, Lachapelle P, Hardy P, Balazy M, Chemtob S (2008) Trans-arachidonic acids induce a heme oxygenase-dependent vasorelaxation of cerebral microvasculature. Free Radic Biol Med. 44:815-825. Dorfman A, Dembinska O, Chemtob S, Lachapelle P (2008) Early manifestations of postnatal hyperoxia on the retinal structure and function of neonatal rat. Investig Ophthalmol Vis Sci. 49:458-466. Houssier M, Raoul W, Keller N, Guilloneau X, Baragatti B, Jonet L, Jeanny JC, Behar-Cohen F, Coceani F, Sherman D, Lachapelle P, Ong H, Chemtob S, Sennlaub F (2008) CD36 deficiency Leads to choroidal involution via COX-2 downregulation. PLoS Medicine. 5:e39 [1-8]. Mwaikambo B, Yang C, Gagnon C, Bossolasco M, Chemtob S, Hardy P (2008) Genetic ablation of CD36 induces age-related spontaneous corneal neovascularization. Corne.a 27:1037-41. Balazy M, Chemtob S (2008) Trans-arachidonic acids: New mediators of nitro-oxidative stress. Pharmacology & Therapeutics. 119:275-290.

Pharmacology and Therapeutics Publications 2008 Quiniou C, Kooli E, Lubell W, Chemtob S (2008) IL-1 and ischemic brain injury – Development of a selective and effective small molecule inhibitor of IL-1 receptor. Seminars in Perinatology. 32:325-333. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Cho JH, Joyal JS, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Lachapelle P, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Di Polo A, Beausejour C, Mitchell G, Andelfinger G, Sennlaub F and Chemtob S (2008) The succinate receptor GPR91 in neurons plays a major role in retinal angiogenesis. Nature Medicine. 14:1067-76. (Editor’s choice in Science Signaling, October 2008; Nature – top 10 papers [2008]). Clarke, Paul Sellings L, Baharnouri G, McQuade L, Clarke P (2008) Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens. Eur. J. Neurosci. 28:342-352. Cuello, Claudio Bell KFS, Zheng L, Fahrenholz F, Cuello AC (2008) ADAM-10 over-expression increases cortical synaptogenesis. Neurobiology of Aging. 29: 554-565. Cuello AC, Canneva F (2008) Impact of intracellular Aβ in transgenic animals and cell models. Neurodegener Dis. Special Edition. 5 (3-4): 146-148. Bell KFS, Cuello AC (2008) Paradoxical increase in glutamatergic synaptic terminations in mild cognitive impairment due to Alzheimer's disease. Med Sci (Paris). 24(10):807-9. Culty, Martine (See also Department of Medicine) Culty M, Thuillier R, Li W, Wang Y, Martinez-Arguelles DB, Benjamin CG, Triantafillou KM , Zirkin BR, Papadopoulos V (2008) In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production. Biology of Reproduction. 78:1018-1028. De Koninck, Yves Prescott SA, De Koninck Y, Sejnowski TJ (2008) Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLoS Comput Biol. 2008 Oct;4(10):e1000198. Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ (2008) Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions. J Neurophysiol. 2008 Dec;100(6):3030-42. Lorenzo LE, Ramien M, St Louis M, De Koninck Y, Ribeiro-da-Silva A (2008) Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat. J Comp Neurol. 2008 Jun 1;508(4):592-604. Di Battista, Giovanni (John) (See Department of Anatomy and Cell Biology)

Pharmacology and Therapeutics Publications 2008 Fellows, Lesley (See Department of Neurology and Neurosurgery) Fiset, Pierre (See Department of Anesthesia) Gauthier, Serge (See Departments of Neurology and Neurosurgery, Psychiatry) Geary, Timothy (See Department of Parasitology) Hales, Barbara Marcon L, Hales BF, Robaire B (2008) Reversibility of the effects of subchronic exposure to the cancer chemotherapeutics bleomycin, etoposide, and cisplatin on spermatogenesis, fertility, and progeny outcome in the male rat. J. Androl. 29:408-417. O'Flaherty C, Vaisheva F, Hales BF, Chan P, Robaire B (2008) Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy. Hum. Reprod. 23:1044-1052. Yan J, Hales BF (2008) p38 and c-Jun N-terminal kinase mitogen-activated protein kinase signaling pathways play distinct roles in the response of organogenesis-stage embryos to a teratogen. J. Pharmacol. Exp. Ther. 326:764-772. Galdones E, Hales BF (2008) Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro. Toxicol. Sci. 106:223-232. Hébert, Terry Baragli A, Grieco ML, Trieu P, Villeneuve LR, Hébert TE (2008) Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional activity following Gs-coupled receptor stimulation. Cellular Signalling. 20:480-492 Chidiac P, Hébert TE (2008) Meeting Review: Advances From the GPCR Retreat Journal of Receptors and Signal Transduction. 28:3-14 Boivin B, Vaniotis G, Allen BG, Hébert TE (2008) G protein-coupled receptors in and on the cell nucleus: a new signalling paradigm? Journal of Receptors and Signal Transduction. 28:15-28 Hébert TE (2008) Opioid and chemokine receptor heterodimers: arranged marriages or dangerous liaisons? Biochem. J. 412:e7-e9 Rebois RV, Robitaille M, Pétrin D, Zylbergold P, Trieu P, Hébert TE (2008) Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells. Methods. 45:214-218

Pharmacology and Therapeutics Publications 2008 Jean-Claude, Bertrand (See Department of Medicine) Kimmins, Sarah (See Department of Animal Science) Laird, Jennifer Laird JMA (2008) Viscero-sensory functions: capsaicin. Encylopedia of Neuroscience. eds: Squire, L.R., Albright,T., Bloom, F., Gage F., and Spitzer N. Academic Press Oxford. UK, pp. 195-201. Laporte, Stéphane (See Division of Experimental Medicine) Mancini, Joseph Guay D, Boulet L, Friesen RW, Girard M, Hamel P, Huang Z, Laliberté F, Laliberté S, Mancini JA, Muise E, Pon D, Styhler A (2008) Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5554-8. Waddleton D, Wu W, Feng Y, Thompson C, Wu M, Zhou YP, Howard A, Thornberry N, Li J, Mancini JA (2008) Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Biochem Pharmacol. 2008 Oct 1;76(7):884-93. Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D (2008) MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63. Friesen RW, Mancini JA (2008) Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target. J Med Chem. 2008 Jul 24;51(14):4059-67. Gallant M, Chauret N, Claveau D, Day S, Deschênes D, Dubé D, Huang Z, Lacombe P, Laliberté F, Lévesque JF, Liu S, Macdonald D, Mancini J, Masson P, Mastracchio A, Nicholson D, Nicoll-Griffith DA, Perrier H, Salem M, Styhler A, Young RN, Girard Y (2008) Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1407-12. Maysinger, Dusica Maysinger D, Kujawa P, Lovric J (2008) Nanoparticles in Medicine. Frontiers in Nanoscience and Technology. Oxford University Press. Maysinger D, Holmes M, Han X, Epand RM, Pertens E, Foerster A, Barlas C, Holtzman DM, Diamond J (2008) Ceramide is responsible for the failure of compensatory nerve sprouting in APOE KO mice. J. Neurosci. 28(31) 7891-7899.

Pharmacology and Therapeutics Publications 2008 Choi AO, Maysinger D (2008) Applications of Quantum Dots. Biomedicine. Springer Publisher, 349-365. Gagné F, Maysinger D, André C, Blaise C (2008) Cytotoxicity of aged cadmium-telluride quantum dots to rainbow trout hepatocytes. Nanotoxicology. 2:3, 113-120. Choi AO, Brown SE, Szyf M, Maysinger D (2008) Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells. J.Mol.Med. 86 (3):291-302. McKinney, R. Anne Hugel S, Abegg M, de Paola V, Carona P, Gähwiler BH, McKinney RA (2008) Dendritic spine morphology determines membrane associated protein exchange between dendritic shafts and spine heads. Cereb. Cortex. 19:697-702. D’Alessio A, Andrews SD, McKinney RA, Szyf M (2008) Transfecting mouse fibroblast NIH 3T3 cells with lipid reagents, a comparative study. Biochemica. McKinney RA, Thompson SM (2008) Glutamate: Regulation of dendritic spine form and function by glutamate. New Encyclopedia of Neuroscience. Elsevier Ltd Oxford McLeod, Peter McLeod P, Brawer J, Steinert Y, Chalk C, McLeod A (2008) Pilot Study Designed to Acquaint Medical Educators with Basic Pedagogic principles. Medical Teacher. 2008; 30:92-93 McLeod P, Steinert Y, Snell L (2008) Use of retrospective pre-post assessments in faculty development. Medical Education. 42:543 Steinert Y, Boillat M, Meterissian S, Liben S, McLeod P (2008) Developing Successful Workshops: a workshop for Educators. Medical Teacher. 30:328-330 McLeod P, Zanelli P, Wiseman J, Chalk C, McLeod A, MacDonald ME (2008) Redesigning Clinical Education for Medical Students: The Emergency Department Complements the In-patient Service.; Canadian Journal of General Internal Medicine. 2008. 3(2) 87-89. Brawer J, Chalk C, McLeod P (2008) The Pedagogic impact of Exploring Philosophical Concepts in the Basic Health Sciences: The Students’ perspective. Journal of the International Association of Basic Science Educators. 18:28-32. Steinert YS, McLeod P. Liben S, Snell L (2008) Writing for Publication in Medical Education; The Benefits of a Faculty Development Workshop and Peer Writing Group. Medical Teacher 30:280, 328-330. Miller, Gregory Quiniou C, Sapieha P, Lahaie I, Hou X, Brault S, Beauchamp M, Leduc M, Rihakova L, Joyal JS, Nadeau S, Heveker N, Lubell W, Sennlaub F, Gobeil F, Miller G, Pshezhetsky A, Chemtob S (2008) Development of a novel noncompetitive antagonist of interleukin-1 receptor. Journal of Immunology. 180:6977-6987.

Pharmacology and Therapeutics Publications 2008 Nattel, Stanley Lemola K, Chartier D, Yeh YH, Dubuc M, Cartier R, Ar mour A, Ting M, Sakabe M, Shiroshita-Takeshita A, Comtois P, Nattel S (2008) Pulmonary vein region ablation in experimental vagal atrial fibrillation: Role of pulmonary veins versus autonomic ganglia. Circulation. 117:470-477. Voigt N, Maguy A, Yeh YH, Qi X, Ravens U, Dobrev D, Nattel S (2008) Augmentation of agonist-independent constitutive IK,ACh channel activity by atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 77:35-43. Ehrlich JR, Biliczki P, Hohnloser SH, Nattel S (2008) Atrial-selective approaches for the treatment of atrial fibrillation. J Am Coll Cardiol. 51:787-792. Burstein B, Nattel S (2008) Atrial fibrosis: Mechanisms and clinical relevance for atrial fibrillation. J Am Coll Cardiol. 51:802 -809. Nattel S (2008) Repolarization indices or calcium-current recovery/repolarization balance: What determines torsadogenesis? Heart Rhythm. 5:280-281. Prystowsky EN, Jaïs P, Kowey P, Nattel S, Ruskin JN (2008) Case studies with the experts: management decisions in atrial fibrillation. J Cardiovasc Electrophysiol. 19:(Suppl 1): S1-12. Shimano M, Tsuji Y, Inden Y, Kitamura K, Uchikawa T, Harata S, Nattel S, Murohara T (2008) Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure. Heart Rhythm. 5: 451-9. Burstein B, Libby E, Calderone A, Nattel S (2008) Differential behaviors of atrial versus ventricular fibroblasts. A potential role for platelet-derived growth factor in atrial-ventricular remodeling differences. Circulation. 117:1630-1641. Nattel S, Burstein B, Dobrev D (2008) Atrial remodelling and atrial fibrillation: Mechanisms and implications. Circulation: Arrhythmia and Electrophysiology. 1:62-73. Sakabe M, Shiroshita-Takeshita A, Maguy A, Brundel BJJM, Fujiki A, Inoue H, Nattel S (2008) Effects of a heat-shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischemia. Cardiovasc Res. 78:63-70. Brundel BJJM, Ke L, Dijkhuis AJ, Qi XY, Shiroshita-Takeshita A, Nattel S, Henning RH, Kampinga HH (2008) Heat shock proteins as molecular targets for intervention in atrial fibrillation. Cardiovasc Res. 78:422-428. Yeh YH, Wakili R, Qi XY, Chartier D, Boknik P, Kääb S, Ravens U, Coutu P, Dobrev D, Nattel S (2008) Calcium handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circulation: Arrhythmia and Electrophysiology. 1:93-102.

Pharmacology and Therapeutics Publications 2008 Roy D, Talajic M, Nattel S, Wyse DG, Dorian P, Lee KL, Bourassa MG, Arnold JMO, Buxton AE, Camm AJ, Connolly SJ, Dubuc M, Ducharme A, Guerra PG, Hohnloser SH, Lambert J, Le Heuzey JY, O’Hara G, Pedersen OD, Rouleau JL, Singh BN, Warner Stevenson L, Stevenson WG, Thibault B, Waldo AL (2008) A multicenter randomized trial of rhythm-control versus rate-control in patients with atrial fibrillation and congestive heart failure. N Engl J Med. 358:2667-77. Nattel S (2008) Complex fractionated atrial electrograms: can they be made simple? Heart Rhythm. 5:855-856. Nattel S (2008) Effects of heart disease on cardiac ion-current density versus current amplitude: Important conceptual subtleties in the language of arrhythmogenic ion-channel remodeling. Circ Res. 102:1298-1300. Diness TG, Yeh YH, Qi XY, Chartier D, Tsuji Y, Olesen SP, Hansen RS, Grunnet M, Nattel S (2008) Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovasc Res. 79:61-69. Burstein B, Nattel S (2008) Atrial structural remodeling as an antiarrhythmic target. J Cardiovasc Pharmacol. 52:4-10. Nattel S (2008) Evolving developments in the therapeutics of atrial fibrillation: addressing an unmet need. J Cardiovasc Pharmacol. 5:1-3. Sun H, Varela D, Chartier D, Ruben PC, Nattel S (2008) Zamponi GW, Leblanc N. Differential Interactions of Na+ Channel Toxins with T-type Ca2+ channels. J Gen Physiol. 132:101-113. Biliczki P, Girmatsion Z, Harenkamp S, Anneken L, Brandes RP, Varro A, Marschall C, Herrera D, Hohnloser SH, Nattel S, Ehrlich JR (2008) Cellular properties of C-terminal KCNH2 long QT syndrome mutations: description and divergence from clinical phenotypes. Heart Rhythm. I 5:1159-1167. Stillitano F, Lonardo G, Zicha S, Varro A, Cerbai E, Mugelli A, Nattel S (2008) Molecular basis of funny current (If) in normal and failing human heart. J Mol Cell Cardiol. 45:289-299. Xiao L, Xiao J, Luo X, Lin H, Wang Z, Nattel S (2008) Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve. Circulation. 118:983-992. Nattel S (2008) Inward rectifier – funny current balance and spontaneous automaticity: cautionary notes for biological pacemaker development. Heart Rhythm. 5:1318-1319. Deng AY, Nattel S, Shi Y, L'Heureux N, Ménard A, Roy J, Tardif JC (2008) Distinct genomic replacements from Lewis correct diastolic dysfunction and attenuate hypertension in Dahl salt-sensitive rats (* shared 1st authorship). J Hypertension. 26:1935-1943. Xiao L, Coutu P, Villeneuve LR, Maguy A, Le Bouter S, Allen BG, Nattel S (2008) Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res. 103:733-742

Pharmacology and Therapeutics Publications 2008 Palardy M, Ducharme A, Nattel S, Tardif JC, White M, Racine N, Tétreault K, Dabouz F, Talajic M, Roy D (2008) CTAF Investigators: Absence of protective effect of renin-angiotensin system inhibitors on atrial fibrillation development: insights from the Canadian Trial of Atrial Fibrillation (CTAF). Can J Cardiol. 9:709-713. Dobrev D, Nattel S (2008) Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. J Cardiovasc Pharmacol 52. 293-299. Comtois P, Sakabe M, Vigmond EJ, Munoz M, Texier A, Shiroshita-Takeshita A, Nattel S (2008) Mechanisms of atrial fibrillation termination by rapidly unbinding sodium channel blockers. Am J Physiol. 295: H1489-H1504. Qi XY, Yeh YH, Xiao L, Burstein B, Maguy A, Chartier D, Villeneuve LR, Brundel BJJM, Dobrev D, Nattel S (2008) Cellular signalling underlying atrial tachycardia remodeling of L-type calcium-current. Circ Res. 103:845-854. Cardin S, Pelletier P, Libby E, Le Bouter S, Xiao L, Kääb S, Demolombe S, Glass L, Nattel S (2008) Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure. J Mol Cell Cardiol. 45:821-831. Ke L, Qi XY, Dijkhuis AJ, Chartier D, Nattel S, Henning RH, Kampinga HH, Brundel BJJM (2008) Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation. J Mol Cell Cardiol. 45:685-693. Van Wagoner DR, Nattel S (2008) Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. J Mol Cell Cardiol. 45:707-708. Nattel S (2008) Delayed rectifier potassium currents and the control of cardiac repolarization: Noble and Tsien 40 years after. J Physiol (Lond) 586(Pt 24). 5849-5852. Andalib A, Brugada R, Nattel S (2008) Atrial Fibrillation: Evidence for genetically determined disease. Curr Opin Cardiol. 23:176-183. Burstein B, Comtois P, Nattel S (2008) Comparisons of substrates responsible for atrial versus ventricular fibrillation. In: Gussak I, Antzelevitch C, Wilde A, Friedman P, Ackerman M, Shen W-K (eds): Electrical Diseases of the Heart and Sudden Death: Genetics, Mechanisms, Treatment, and Prevention (Chapter 19). Springer Publishing, Guildford, UK 2008, pp 261-280. Ehrlich JR, Coutu P, Yeh HI, Qi X, Nattel S (2008) Cellular electrophysiology and the substrate for atrial fibrillation. In: Natale A, Jalife J (eds). Atrial Fibrillation: From Bench to Bedside. Totowa, NJ: Humana Press 2008, pp 37–56. O’Flaherty, Cristian (See also Department of Urology) O'Flaherty C, Vaisheva F, Hales BF, Chan P, Robaire B (2008) Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy. Hum Reprod. 2008 May;23(5):1044-52

Pharmacology and Therapeutics Publications 2008 Papadopoulos, Vassilios (See also Department of Medicine) Culty M, Thuillier R, Li W, Wang Y, Martinez-Arguelles DB, Benjamin CG, Triantafillou KM , Zirkin BR, Papadopoulos V (2008) In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production. Biology of Reproduction. 78:1018-1028. Prichard, Roger (See Department of Parasitology) Quirion, Remi (See Department of Psychiatry) Ribeiro-da-Silva, Alfredo Majdi M, Ribeiro-da-Silva A, Cuello AC (2008) Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status. Neuroscience. 159: 896-907. Lorenzo LE, Ramien M, St.Louis M, De Koninck Y, Ribeiro-da-Silva A (2008) Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat. J.Comp.Neurol. 508:592-604. Almarestani L, Longo G, Ribeiro-da-Silva A (2008) Autonomic fiber sprouting in the skin in chronic inflammation. Molecular Pain. 4:56. Ribeiro-da-Silva A, De Koninck Y (2008) Morphological and neurochemical organization of the spinal dorsal horn. Pain. edited by M. C. Bushnell and A. I. Basbaum, New York: Academic Press, p. 279-310 Robaire, Bernard Tempest HG, Ko E, Chan P, Robaire B, Rademaker A, Martin RH (2008) Sperm aneuploidy frequencies analyzed before and after chemotherapy in testicular cancer and Hodgkin's lymphoma patients. Hum. Reprod. 23: 251-258. O’Flaherty C, Vaisheva F, Hales BF, Chan P, Robaire B (2008) Characterization of sperm chromatin quality in testicular cancer and Hodgkin’s lymphoma patients prior to chemotherapy. Hum. Reprod. 23: 1044-1052. Marcon L, Hales BF, Robaire B (2008) Reversibility of the effects of subchronic exposure to the cancer chemotherapeutics Bleomycin, Etoposide, and Cisplatin on spermatogenesis, fertility and progeny outcome in the male rat. J Androl. 29: 408-417. Boyer A, Hermo L, Paquet M, Robaire B, Boerboom D (2008) Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in Sertoli cells. Biol Reprod. 79: 475-485. Zirkin BR, Schlegel P, Robaire B, Perreault S (2008) In Memoriam: Matthew P. Hardy, Ph.D., 1957-2007. J. Androl. 2007 Nov 28; PMID: 18046047

Pharmacology and Therapeutics Publications 2008 Robaire B (2008) The Challenges of Assessing the Quality of Spermatozoa. Fert. Ster. 89(2 Suppl): e 67 68. Robaire B (2008) Is it my grandparents’ fault? Nat Med. 14:1186-7. Rousseau, Simon (See Department of Medicine) Saragovi, H. Uri Angell Y, Chen D, Brahimi F, Saragovi HU, Burgess K (2008) A combinatorial method for solution-phase synthesis of labeled bivalent beta-turn mimics. J Am Chem Soc. Jan 16;130(2):556-65. Zhuo YH, Wei YT, Bai YJ, Duan S, Lin MK, Saragovi HU, Ge J (2008) Pro370Leu MYOC gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype. Mol Vis. Aug 22;14:1533-9. Shi Z, Rudzinski M, Meerovitch K, Lebrun-Julien F, Birman E, Di Polo A, Saragovi HU (2008) alpha 2 macroglobulin is a mediator of retinal ganglion cell death in glaucoma. J Biol Chem. 283(43):29156-65 Lebrun-Julien F, Morquette B, Douillette A, Saragovi HU, Di Polo A (2008) Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Mol Cell Neurosci. Apr;40(4):410-20. Epub 2008 Dec 25 Kojic LD, Wiseman SM, Ghaidi F, Joshi B, Nedev H, Saragovi HU, Nabi IR (2008) Raft-dependent endocytosis of autocrine motility factor/phosphoglucose isomerase: a potential drug delivery route for tumor cells. PLoS One. 3(10):e3597. Shir, Yoram (See MUHC Pain Center) Szyf, Moshe Patra S, Szyf M (2008) DNA methylation mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FASL and RASSF1A. FEBS J. 275:5217-35 McGowan PO, Meaney MJ, Szyf M (2008) Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res. 1237:12-24. Poulter MO, Du L, Weaver IC, Palkovits M, Faludi G, Merali Z, Szyf M, Anisman H (2008) GABA(A) Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes. Biol Psychiatry. 64:645-52. Ernst C, McGowan PO, Deleva V, Meaney MJ, Szyf M, Turecki G (2008) The effects of pH on DNA methylation state: In vitro and post-mortem brain studies. J Neurosci. Methods. 174:123-5. Brown SE, Suderman MJ, Hallet M, Szyf M (2008) DNA demethylation induced by the methyl-CpG-binding domain protein MBD3. Gene. 420: 99-106.

Pharmacology and Therapeutics Publications 2008 Brown SE, Weaver IC, Meaney MJ, Szyf M (2008) Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus. Neuroscience lett. 440: 49-53. Cameron NM, Shahrokh D, Del Corpo A, Dhir SK, Szyf M, Champagne FA, Meaney MJ (2008) Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care. J. Neuroendocrinol. 20:795-801. McGowan PO, Sasaki A, Huang TC, Unterberger A, Suderman M, Ernst C, Meaney MJ, Turecki G, Szyf M (2008) Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain. PLoS ONE 3. e2085. Szyf M (2008) The role of DNA methylation and demethylation in cancer and cancer therapy. Curr. Oncol. 15:72-75. Choi AO, Brown SE, Szyf M, Maysinger D (2008) Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells. J Mol. Med. 86:291-302. Ateeq B, Unterberger A, Szyf M, Rabbani SA (2008) Pharmacological inhibition of DNA methylation induces pro-invasive and pro-metastatic genes in vitro and in vivo. Neoplasia. 10:1-13. Hamm S, Just G, Lacoste N, Moitessier N, Szyf M, Mamer O (2008) On the mechanism of demethylation of 5-methylcytosine in DNA. Bioorg Med Chem Lett. 18:1046-1049. Brown SB, Szyf M (2008) Dynamic epigenetic states of ribosomal RNA promoters during the cell cycle. Cell Cycle. 7:382-90. Unterberger A, Torrisani J, Szyf M (2008) A method for purification, identification and validation of DNMT1 mRNA binding proteins. Biol Proceed Online. 10:47-57. Szyf M, Meaney MJ (2008) The social environment and the epigenome. Environ. Mol. Mutagen. 49:46-60. Varma, Daya Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Cho JH, Joyal JS, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Lachapelle P, Hardy P, Klein WH, Mu X, Mamer O, Di Polo A, Beausejour C, Mitchell G, Andelfinger G, Sennlaub F, Chemtob S (2008) The succinate receptor GPR91 in neurons plays a major role in retinal angiogenesis. Nature Medicine. 14:1067-1076. Yang, Xiang-Jiao (See McGill University Rosaline & Morris Goodman Cancer Center) Zingg, Hans

Pharmacology and Therapeutics Publications 2008 Haddad R, Romero R, Gould B, Tromp G, Edwin S, Zingg HH (2008) Angiogenesis Gene Expression in the Common Terminal Pathway of Parturition in Mice. American Journal of Obstetrics & Gynecology. 198:539.e1-e8 Devost D, Carrier ME, Zingg HH (2008) Oxytocin-induced activation of eukaryotic elongation factor eEF2 in myometrial cells is mediated by protein kinase C. Endocrinology. 149:131-138. Gassanov N, Devost D, Bogdan Danalache B, Nicolas Noiseux N, Marek Jankowski M, Zingg HH, Gutkowska J (2008) Functional activity of the carboxy-terminally extended oxytocin precursor peptide during cardiac differentiation of embryonic stem cells. Stem Cells. 26:45-54. Young L, Zingg HH (2008) Oxytocin. In: “Brain, Hormones and Behavior”, Section: “Mammalian, Hormone-Behavior Systems” (D Pfaff, AP Arnold, AM Etgen and SE Fahrbach, editors). 2nd edition. Academic Press, San Diego, CA. Devost D, Wrzal P, Zingg HH (2008) Oxytocin receptor signaling. In: "Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease". I.D. Neumann and R. Landgraf, editors. Progress in Brain Research. Vol. 170, pp. 167-176. Zorychta, Edith (See Department of Pathology)