pharmacology 200 pain management-clinical principles › __data › assets › pdf... · understand...
TRANSCRIPT
![Page 1: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/1.jpg)
Pharmacology 200 Pain Pharmacology
Clinical Applications
Eric J. Visser V2 October 2016
![Page 2: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/2.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 2
Learning objectives Know definitions of pain and nociception .
Understand the difference between them.
Appreciate that pain is a complex, multi-dimensional, whole-person experience
not a sensation.
Know that you can experience pain without tissue damage.
Understand terms: acute, chronic, cancer, nociceptive & neuropathic pain.
Understand basic anatomy, physiology & clinical pharmacology of nociceptive
(‘pain’) pathways from periphery to spinal cord to brain.
Understand where ‘pain’ receptors, ion channels & enzymes act along this
pathway.
![Page 3: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/3.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 3
Learning objectives Understand that central sensitization (CS) (amplifier) and…
conditioned pain modulation (damper)…
modulate nociceptive (‘pain signal’) traffic in the CNS.
Know that allodynia (touch pain) is the clinical sign for CS.
Understand where analgesic drugs act along the ‘pain pathway’.
Have a basic understanding of clinical pharmacology of analgesic drugs
presented in this lecture & slide presentation.
Understand basic principles of acute, chronic & neuropathic pain management.
Pain is managed using bio-medical-psycho-social–environmental approach.
![Page 4: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/4.jpg)
Pain is ‘an unpleasant sensory & emotional experience…
…associated with actual or potential tissue damage’ (IASP 1979)
Pain is an output of the conscious brain & not an input
Pain is a subjective, multidimensional, whole-person experience
Pain always occurs in a bio-medical-psycho-social-environmental
context
Visser MED 200 UNDA pain pharmacology 2016 4
![Page 5: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/5.jpg)
‘Processing & encoding of noxious stimuli (tissue damage) in the nervous system’ (IASP 2011)
Transduces the ‘energy’ released by tissue damage… …chemical, mechanical & thermal energy… …into electrical signals for processing in nervous system Nociception is a neuro-physiological process
Nociception is the main (but not the only) trigger for pain Nociception is NOT the same as pain
Visser MED 200 UNDA pain pharmacology 2016 5
![Page 6: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/6.jpg)
The difference between pain & nociception explained in a movie!
Terminator II-Judgment Day (1991)
John Connor: “Does it hurt when you get shot”?
The Terminator: “I sense injuries (a great definition of nociception) ... The data could be called ‘pain’”.
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 6
![Page 7: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/7.jpg)
DRG
transmission transduction modulation
Visser MED 200 UNDA pain pharmacology 2016 7
transmission
Dorsal horn Energy of tissue damage TRPV channels
Inflammatory soup
voltage gated Na ion channels
Descending inhibition ‘signal inhibition’
Central sensitization ‘signal amplification’
Aδ & C fibres
![Page 8: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/8.jpg)
Nociceptive (inflammatory) ‘soup’
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 8
![Page 9: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/9.jpg)
Immune modulation of nociception in the nervous system
Toll-like receptor 4
Interleukin 1, 6, TNF
![Page 10: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/10.jpg)
Nociceptors Convert the energy released by tissue damage into neuro-electrical signals
Heat Acid (H+)
TRPV1
Mechanical
Cold
TRPV8
DRG
Capsaicin cream 0.025%
Menthol gel 2-4%
Bandage, cast, splint
![Page 11: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/11.jpg)
NOCICEPTION
Nociceptive (inflammatory) soup Prostaglandins
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 11
![Page 12: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/12.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 12
vasodilation mucous platelet plug tissue growth
renal stomach bone, gut
Cyclooxygenase (COX) Produces prostaglandins
![Page 13: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/13.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 13
Cyclooxygenase COX-1 constitutive (’housekeeping’) enzyme
![Page 14: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/14.jpg)
Boosts inflammation in disease eg arthritis
COX-2 found in CNS ( central sensitization)
Stomach mucous production is COX-1 (↓ peptic ulcer)
COX tissue growth, cancer cells (↓ colon cancer?)
Platelets do not have COX-2 (↓ bleeding risk)
Renal arterioles (have COX-2) (still renal risk)
Vascular (still hypertension & CVS risk)
Celecoxib, parecoxib
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 14
COX-2 (coxibs) Inducible (‘spring cleaning’) enzyme
(at times of tissue or organ stress)
![Page 15: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/15.jpg)
Antidepressants Effective for neuropathic (nerve) pain
Na+
NA ()
Tricyclic antidepressants (are best, NNT 3)
SNRIs (eg duloxetine) (quite effective, NNT 6)
SSRIs (not effective)
(Nor) adrenaline is the body’s main pain-killing neurotransmitter
‘Adrenaline is an analgesic’ TCAs also block Na channels & NMDA
Amitriptyline is a ‘dirty drug’ that
works at multiple sites NMDA
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 15
NA
5HT
![Page 16: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/16.jpg)
Anticonvulsants Extinguish ‘’sparking wires’’ in neuropathic pain
DRG
Na+
‘Membrane stabilizers’ -↓ spontaneous electrical activity (ectopics)
-neuropathic pain -migraine
Block voltage gated Na ion channels -carbamazepine (NNT 2)
-valproate -lignocaine
Block specialized calcium channels (the α2δ subunit)
-pregabalin, gabapentin (NNT 4)
Na+
Na+
Na+
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 16
Ca++
α2δ
![Page 17: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/17.jpg)
Dorsal horn This is where pain signal processing (modulation) goes on
![Page 18: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/18.jpg)
Site of the ‘pain gate’
![Page 19: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/19.jpg)
lllllllllllllllllllll 50 Hz
Central Sensitization ‘Pain’ signal (nociceptive) amplification
Dorsal horn
It makes sense for an ‘alarm’ to ‘ring’ louder so we don’t ignore it
‘Increased nociceptive output for a given nociceptive input’
1 1 1 1 1 1 1 1 1 1 1 1 1 3Hz
A true amplifier effect ‘Wind-up’
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 19
NMDA
Capacitance effect pain signal ‘memory’
![Page 20: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/20.jpg)
Allodynia (touch pain) Is the clinical sign for central sensitization
Greek for ‘the other pain’
If any of these non-painful stimuli feels painful,
you have detected allodynia…
...and therefore central sensitization
![Page 21: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/21.jpg)
NMDA receptor ion channel N-methyl-D-Aspartate
The nervous system’s signal amplifier (chemical ‘transistor’)
Glutamate is an NMDA agonist Main excitatory amino acid (MSG)
NMDA is amplifier channel in dorsal horn & brain
Mediates central sensitization -’wind-up’ -memory (hippocampus) Blocked by… -ketamine -dextromethorphan -TCAs -methadone
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 21
![Page 22: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/22.jpg)
Conditioned Pain Modulation (CPM)
Descending ‘pain’ (nociceptive) inhibitory system
Inhibits ‘pain signals’ ascending from
dorsal horn
Damping (pain brake)
Inhibitory neurotransmitters
-noradrenaline (the most important)
-serotonin
-endorphins
CPM allows us to sit on our bottoms
- there’s 45 kg/cm2 pressure on our ischium when we sit
CPM allows us to escape danger…
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 22
![Page 23: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/23.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 23
![Page 24: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/24.jpg)
Pain Modulation in Balance
CPM
“Damper”
Sensitization
“Amplifier”
Pain signal
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 24
![Page 25: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/25.jpg)
Opioids Slow everything down
DRG
OR
mu, delta, kappa, nociceptin receptors MOP DOP KOP NOP (IUPHAR)
Neuro + endocrine + immune inhibitors ‘Opioids slow everything down’ Analgesia Side effects -brain (sedation) -breathing, coughing -gut (constipation, gastric stasis, ileus) -bladder (retention) -person (lethargy)
OR
OR
OR
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 25
![Page 26: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/26.jpg)
Opioids
Opioids are plant alkaloids Alkaloids have a similar structure to endogenous
opioids (nature is amazing)
eg endorphins, leu-enkephalin
Papaver somniferum
Leu-enkephalin
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 26
![Page 27: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/27.jpg)
Opioid receptors 7-membrane-spanning array-type receptors
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 27
K+
Australian Prescriber 1996: 19 (3)
Ca++
![Page 28: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/28.jpg)
Codeine (3-methyl-morphine)
Example of a pro-drug
Prodrug is converted by the liver to its active form
Codeine cytochrome P4502D6 (de-methylated) morphine (active)
Di-acetyl-morphine (heroin) & tramadol are also pro drugs
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 28
![Page 29: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/29.jpg)
Codeine (3-methyl-morphine)
Genetic polymorphism of cytochrome P450 2D6
Pharmacogenomics (isoenzymes)
10% slow metabolisers (it doesn’t work)
10% fast metabolisers (one tablet & I’m out)
-30% of Africans & Middle East (risk of toxicity)
Paediatric breast feeding & tonsillectomy deaths
Social impacts of pharmacogenomics…
Refugees from Middle East & Africa
Change to S4 drug next year
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 29
![Page 30: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/30.jpg)
Summary Pain Pharmacotherapy Targets
Follow the pain pathway
DRG Na+
Ca++ (2)
lignocaine anticonvulsants (carbamazepine)
capsaicin menthol
NSAIDs, coxibs, steroids
gabapentin pregabalin
ketamine
OR
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 30
NMDA
opioids
NA 5HT
Antidepressants Tramadol
Tapentadol
![Page 31: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/31.jpg)
We’ve run out of time
Please read the following slides for self study
Don’t get too worried
There’s a fair bit there but take your time
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 31
![Page 32: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/32.jpg)
Clinical pain management
Key principles
Always believe the person-in-pain
Try to make a pain diagnosis (can you identify a pain ‘generator’?)
-NB may not always be possible (eg chronic low back pain)
Make a pain assessment: QRST
-Quality, Radiation/Relieving, Site/Severity, Timing
Is the pain nociceptive or neuropathic?
Is the pain acute, chronic, cancer, visceral?
Always apply a bio-medical-psycho-social approach
Always manage the whole person-in-pain (often a lot happening in their life)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 32
![Page 33: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/33.jpg)
Types of pain Acute pain
Chronic pain
Cancer pain
Nociceptive pain (tissue injury or ‘inflammatory’ pain)
Neuropathic pain (nerve pain)
Visceral pain (pain from internal organs)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 33
![Page 34: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/34.jpg)
Acute Pain
‘Alarm’ system pain
Nociceptive pain
Inflammatory pain
Pain ≈ amount of tissue damage
Pain gets better as tissues heal
Protective & adaptive
Highly preserved in evolution &
animal kingdom
From crustaceans (?) to humans
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 34
![Page 35: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/35.jpg)
Acute pain is nature’s tissue-damage ‘alarm’
![Page 36: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/36.jpg)
Acute pain
Emergency (retrieval)
Post operative pain (recovery room)
Acute Pain Service rounds
Labour ward
Work or sports injury
Renal colic
Migraine
Dysmenorrhoea
Acute coronary syndrome
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 36
![Page 37: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/37.jpg)
Treat acute pain fast by… Establishing a therapeutic steady-state plasma [ ] of the analgesic...
Remember, it takes 5 drug half-lives to reach steady-state
IV loading for acute pain is fastest!
-bolus every 2 mins to effect
Oral loading is a bit slower
-Rx…1/24 prn for opioids or tramadol
A bit of applied pharmacokinetics…
Most opioids have a t1/2 of 3 hrs,
so it would take 15 hrs (5 x 3 hrs)
to reach a therapeutic SS plasma [ ] if we prescribed ‘3/24 prn’
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 37
![Page 38: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/38.jpg)
Treat an acute pain emergency by… Getting an adequate brain concentration of analgesic
It’s a gas treating severe pain fast
Gas gets from lungs-to-brain fast
That’s how anaesthesia works!
Nitrous oxide (Entonox®)
Methoxyflurane (Penthrane®)
eg labour pain
renal colic
painful dressings
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 38
![Page 39: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/39.jpg)
Analgesia league table for acute pain
NNT
Celecoxib 400 mg 2
Ibuprofen 400 mg 3
Pethidine 100 mg, morphine 10 mg inj. 3
Panadeine forte 60/1000 mg 3
Paracetamol 1000mg 4
Tramadol 100 mg 5
Codeine 60 mg 17
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 39
![Page 40: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/40.jpg)
Chronic pain
Pain alarm malfunction
Pain lasting beyond the time of normal tissue healing
Pain lasting ≥ 3 months
No protective function (mal-adaptive)
Alarm keeps ringing when there’s no emergency
Pain ≠ amount of tissue damage
Key message (remember this)…
You CAN experience pain without any tissue damage
eg pressing your thumb nail, phantom limb pain, or back pain with a
normal looking MRI (insurance companies can’t understand this?)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 40
![Page 41: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/41.jpg)
Cancer pain
Acute or chronic
Nociceptive pain (eg metastatic, pathological #)
Neuropathic pain (eg lumbar plexus infiltration)
Visceral pain (eg bowel obstruction)
Due to treatment effects (chemo, radiotherapy, surgery)
Psycho-social, spiritual, existential dimensions
Palliative care
Opioid analgesia is the mainstay of Rx
WHO analgesia ladder
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 41
![Page 42: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/42.jpg)
Neuropathic (nerve) pain
Pain due to a lesion or disease of the nervous system (IASP 2011)
PNS - Nerve injury
- Radicular (nerve root)
- PDN (diabetes), PHN (zoster)
- trigeminal neuralgia
CNS (central pain)
- spinal cord injury
- post-stroke pain
- multiple sclerosis
42 VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016
![Page 43: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/43.jpg)
Neuropathic pain No physiological function (maladaptive)
Damage to pain ‘wires’
Sparks from a fallen power line (‘ectopics’)
Pain has ‘electrical’ qualities
Shooting, zapping, shocks, lightning
Stabbing, burning, aching
Allodynia (touch pain)
Numbness, weakness?
Nerve damage leads to over-production of Na & Ca ion channels
Pathological increase in nerve function
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 43
![Page 44: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/44.jpg)
Visceral pain Primitive, emotional & autonomic pain
Pain from internal organs eg renal colic, AMI, labour pain, dysmenorrhea, IBS
Transmitted via C pain fibres (slow, burning, aching pain)
Transmitted via the old (paleo) spinal cord pathways
-medial cord tracts (spino-parabrachial-limbic) & dorsal columns
Signals project to limbic system (emotional & autonomic part of the brain)
-↑ emotions (distress), ↑ pain behaviors (grimacing, groaning, rolling around)
-↑ autonomic response (nausea, sweating, vasovagal)
Poorly-localized pain, deep, dull, burning, gripping, ‘colicky’
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 44
![Page 45: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/45.jpg)
Do opioids work for chronic pain? This is a big question in health care at the moment
No, not that well: NNT = 8 (NNH = 4) (Level I)
More effective in over 60s (but more side effects)
Avoid in LBP, headache, fibromyalgia, abdominal pain
Ceiling dose is ≤ 90 mg oral morphine equivalents/day
Don’t prescribe more than this for chronic pain
Use tramadol SR, tapentadol SR or transdermal buprenorphine
Opioid prescribing is always a therapeutic trial
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 45
![Page 46: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/46.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 46
Respiratory, sedation, dizziness, nausea, constipation
Overuse (chemical-coping, addiction) (+ reward centre)
Opioid-induced hyperalgesia & tolerance (pain gets worse)
Endocrine changes (testosterone, osteoporosis)
Immune suppression; activates glia via Toll-like receptors
Cortical changes on fMRI (cognitive, anxiety, mood, motivation)
Increased all cause mortality
What are the adverse effects of long-term opioids?
![Page 47: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/47.jpg)
WHO analgesia ladder (1986) A major breakthrough in pain management
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 47
![Page 48: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/48.jpg)
Paracetamol
No one really knows how it works
COX inhibition?
Cannabinoid & serotonin receptor agonist?
30% ↓ in pain, 30% opioid sparing
IV > oral > PR (satisfaction & dose reliability)
Toxicity (liver)
Reduce the dose in old, frail, < 45 kg, alcoholism
May not be effective for chronic musculoskeletal pain (meta analysis)?
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 48
![Page 49: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/49.jpg)
NSAIDs & coxibs
Best analgesics for acute pain (level I) (see league table)
30% ↓ in pain & 30% opioid sparing
Kidneys at risk (↓renal blood flow)
Hypertension/acute coronary syndrome/stroke (long term)
Coxibs ↓ gastric irritation & no bleeding risk
Celecoxib has best overall safety profile (gut, CVS, bleeding)
Naproxen has best long term CVS risk
Use NSAIDs & coxibs for acute pain, avoid long term use
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 49
![Page 50: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/50.jpg)
Tramadol
1/3rd opioid, 1/3rd nor-adrenaline, 1/3rd serotonin analgesia effect
Metabolised by cytochrome P450 2D6 (same pharmacogenomics as codeine)
11 active metabolites (so it’s a pro drug, the metabolites provide the analgesia)
Accumulates in renal impairment (reduce the dose)
Good for neuropathic pain (NNT = 4)
Less addiction (S4), tolerance & hyperalgesia
Less respiratory depression (better in COPD, sleep apnoea)
Less constipation
Can mix carefully with antidepressants (serotonin syndrome, 1/7000)
Avoid if risk of seizures
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 50
![Page 51: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/51.jpg)
Tapentadol SR Like tramadol without the serotonin
Mu opioid receptor agonist (MOR) (S8 drug) & nor adrenaline reuptake inhibitor (NOR) in the same molecule
Noradrenaline is main pain inhibitory neurotransmitter
Works via CPM pathway in the spinal cord
Effective in nociceptive & neuropathic pain (NNT 4)
Less, constipation, less side effects than tramadol
Minimal accumulation in renal impairment
OK to combine with TCAs, SSRIs or SNRIs in sensible doses
Tapentadol SR 50 mg ~ 10 mg oral oxycodone ~ 20 mg oral morphine
Consider first line if prescribing opioids for chronic non cancer pain
Visser MED 200 UNDA pain pharmacology 2016 51
![Page 52: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/52.jpg)
Pain Pathways Rene Descartes
"Particles of heat activate a spot of skin attached by a fine thread to a valve in the brain… this opens the valve allowing animal spirits to flow from a cavity into the muscles causing them to flinch, and turn the head and eyes toward the affected body part, also moving the hand and turn the body protectively.”
![Page 53: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/53.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 53
vasoconstriction mucous platelet plug tissue growth
renal, gut BF BP, CVS risk peptic ulcer bone healing
Cyclooxygenase COX-1 Adverse effects of blocking COX-1
bleeding
↓ ↓ ↓ ↓
↓ ↑
↑ ↑ ↑
![Page 54: Pharmacology 200 Pain Management-Clinical Principles › __data › assets › pdf... · Understand basic anatomy, physiology & clinical pharmacology of nociceptive (‘pain’) pathways](https://reader033.vdocuments.us/reader033/viewer/2022060501/5f1b44111163797d067e7a4a/html5/thumbnails/54.jpg)
VISSER MED 200 UNDA PAIN PHARMACOLOGY 2016 54