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PharmaceuticsDosage Formand Design
David JonesChair of Biomaterial Science,School of Pharmacy,Queen's University of Belfast, UK
Pharmaceutical PrPharmaceutical PressLondon • Chicago
Contents
Introduction to the FASTtrack series
Preface
About the author
1. Pharmaceutical solutions for oraladministration
VII
viii
X
General description
Advantages and disadvantages ofpharmaceutical solutions for oraladministration
Drug solubility
Excipients used in pharmaceuticalsolutions for oral administration
Types of pharmaceutical solutions
Multiple choice questions
. 11
2
2
61521
2. Pharmaceutical disperse systems 1:suspensions - general principles andthe formulation of suspensions for oraladministration 25
General description 25
Advantages and disadvantages ofpharmaceutical suspensions 26
The physical stability of pharmaceuticalsuspensions 27
Formulation considerations for orallyadministered suspension formulations 33
Excipients used in the formulation ofsuspensions for oral administration 35
Multiple choice questions 42
3. Pharmaceutical disperse systems 2:emulsions and creams 45
General description 45
Advantages and disadvantages ofpharmaceutical emulsions 46
Emulsion instability and theories ofemulsification 47
Formulation of pharmaceutical emulsions 55
Excipients used in pharmaceuticalemulsions 65
Manufacture of emulsions 70
Multiple choice questions 70
4. Pharmaceutical disperse systems 3:ointments, pastes, lotions, gels andrelated formulations 75
Introduction 75
Advantages and disadvantages ofpharmaceutical ointments, pastes,lotions, liniments, collodions and gels 76
Pharmaceutical ointments and pastes 77
Pharmaceutical lotions, liniments,collodions and paints 86
Pharmaceutical gels 88
Multiple choice questions 99
5. Parenteral formulations 103
General description 103
Routes of parenteral administration 103
Advantages and disadvantages ofparenteral formulations 106
Formulation considerations forparenteral formulations 108
Surface-active agents 115
Multiple choice questions 131
6. Ocular, nasal and otic dosage forms.. 135
Introduction 135
Advantages and disadvantages ofocular dosage forms 136
Administration of therapeutic agentsto the eye 137
Nasal formulations 150
Otic formulations 152
Multiple choice questions 154
7. Vaginal and rectal dosage forms . . . . 157
Introduction 157
Rectal dosage forms 157
Vaginal dosage forms 174
Multiple choice questions 177
8. Respiratory dosage forms 181
Introduction 181
Advantages and disadvantages ofrespiratory drug delivery 181
Contents
Physiology of the respiratory tract 182
Factors affecting the deposition ofparticles/droplets within the respiratorytract 184
Mechanisms of particle deposition
within the respiratory tract 185
Formulation of respiratory dosage forms 187
Multiple choice questions 199
9. Solid-dosage forms 1: tablets 203
Introduction 203
Advantages and disadvantages of
tablets as dosage forms 209
Manufacture of tablets 210
Tablet defects 243
Postprocessing effects on tabletproperties 243
Coating of tablets
Multiple choice questions
10. Solid-dosage forms 2: capsules . . .
Introduction
Advantages and disadvantages ofcapsule formulations 256
Materials and manufacture ofcapsules 256
Formulation considerations for hardgelatin capsules 260
Soft gelatin capsules 266
Multiple choice questions 270
Multiple choice answers 273Index 276